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Aliases for THAP11 Gene

Aliases for THAP11 Gene

  • THAP Domain Containing 11 2 3 5
  • THAP Domain-Containing Protein 11 3
  • HRIHFB2206 3
  • CTG-B43a 3
  • CTG-B45d 3
  • RONIN 3

External Ids for THAP11 Gene

Previous GeneCards Identifiers for THAP11 Gene

  • GC16U900023
  • GC16P067652
  • GC16P066433
  • GC16P067876
  • GC16P053749

Summaries for THAP11 Gene

Entrez Gene Summary for THAP11 Gene

  • The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

GeneCards Summary for THAP11 Gene

THAP11 (THAP Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for THAP11 Gene

  • Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

Additional gene information for THAP11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP11 Gene

Genomics for THAP11 Gene

Regulatory Elements for THAP11 Gene

Enhancers for THAP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H067555 1.5 Ensembl ENCODE dbSUPER 18.6 -285.8 -285774 2 ZNF493 ZFP64 ZNF121 FOS KLF7 ZNF202 ZC3H11A REST ZNF623 ZNF518A ZDHHC1 EDC4 CENPT ENSG00000260465 CTCF ENKD1 NAE1 E2F4 ENSG00000263276 ACD
GH16H067987 1.1 Ensembl ENCODE 18.6 +145.6 145561 1 ELF3 ZNF493 ZFP64 ARID4B RAD21 KLF7 ZNF680 ZC3H11A REST ZNF518A ZDHHC1 EDC4 CENPT ENKD1 CTCF E2F4 FBXL8 ACD ENSG00000263276 KIAA0895L
GH16H068077 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +243.6 243600 16 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PRMT7 CTCF EDC4 TRADD ZDHHC1 DPEP2 DUS2 E2F4 SLC7A6OS ENSG00000212445
GH16H067013 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -827.9 -827898 2.2 ATF1 ARNT SIN3A ZNF121 GLIS2 ZNF416 ZNF143 ZNF207 ATF7 RUNX3 EDC4 ACD NAE1 CENPT THAP11 CBFB ATP6V0D1 RIPOR1 CES4A FBXL8
GH16H067934 1.4 ENCODE dbSUPER 11.5 +94.2 94185 4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 NFATC3 EDC4 DPEP3 THAP11 NRN1L PSKH1 DUS2 LCAT SLC12A4 E2F4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP11 on UCSC Golden Path with GeneCards custom track

Promoters for THAP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087183 418 1801 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207

Genomic Locations for THAP11 Gene

Genomic Locations for THAP11 Gene
chr16:67,842,082-67,844,195
(GRCh38/hg38)
Size:
2,114 bases
Orientation:
Plus strand
chr16:67,876,213-67,878,098
(GRCh37/hg19)

Genomic View for THAP11 Gene

Genes around THAP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP11 Gene

Proteins for THAP11 Gene

  • Protein details for THAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK4-THA11_HUMAN
    Recommended name:
    THAP domain-containing protein 11
    Protein Accession:
    Q96EK4
    Secondary Accessions:
    • A4UCT5
    • A8K002
    • O94795

    Protein attributes for THAP11 Gene

    Size:
    314 amino acids
    Molecular mass:
    34455 Da
    Quaternary structure:
    • Interacts (via coiled coil domain) with HCFC1.

    Three dimensional structures from OCA and Proteopedia for THAP11 Gene

neXtProt entry for THAP11 Gene

Post-translational modifications for THAP11 Gene

  • Ubiquitination at posLast=2828 and posLast=3838
  • Modification sites at PhosphoSitePlus

Other Protein References for THAP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP11 Gene

Domains & Families for THAP11 Gene

Gene Families for THAP11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP11 Gene

Suggested Antigen Peptide Sequences for THAP11 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EK4

UniProtKB/Swiss-Prot:

THA11_HUMAN :
  • Belongs to the THAP11 family.
Family:
  • Belongs to the THAP11 family.
genes like me logo Genes that share domains with THAP11: view

Function for THAP11 Gene

Molecular function for THAP11 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

Phenotypes From GWAS Catalog for THAP11 Gene

Gene Ontology (GO) - Molecular Function for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19008924
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19008924
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IDA 23306615
GO:0005515 protein binding IPI 18585351
genes like me logo Genes that share ontologies with THAP11: view
genes like me logo Genes that share phenotypes with THAP11: view

Animal Models for THAP11 Gene

MGI Knock Outs for THAP11:

Animal Model Products

Targeted motifs for THAP11 Gene
HOMER Transcription Factor Regulatory Elements motif THAP11
  • Consensus sequence: RACTACAACTCCCAGVAKGC Submotif: canonical Cell Type: ES GEO ID: GSE51522

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for THAP11 Gene

Localization for THAP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP11 Gene

Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with THAP11: view

Pathways & Interactions for THAP11 Gene

SuperPathways for THAP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19008924
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with THAP11: view

No data available for Pathways by source and SIGNOR curated interactions for THAP11 Gene

Drugs & Compounds for THAP11 Gene

No Compound Related Data Available

Transcripts for THAP11 Gene

mRNA/cDNA for THAP11 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(146) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THAP11 Gene

THAP domain containing 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP11 Gene

No ASD Table

Relevant External Links for THAP11 Gene

GeneLoc Exon Structure for
THAP11
ECgene alternative splicing isoforms for
THAP11

Expression for THAP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP11 Gene

Protein differential expression in normal tissues from HIPED for THAP11 Gene

This gene is overexpressed in Lung (49.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THAP11 Gene



Protein tissue co-expression partners for THAP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP11 Gene:

THAP11

SOURCE GeneReport for Unigene cluster for THAP11 Gene:

Hs.632200

Evidence on tissue expression from TISSUES for THAP11 Gene

  • Nervous system(4.5)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with THAP11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP11 Gene

Orthologs for THAP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP11 33 34
  • 98.82 (n)
rat
(Rattus norvegicus)
Mammalia Thap11 33
  • 89.18 (n)
cow
(Bos Taurus)
Mammalia THAP11 33 34
  • 88.78 (n)
dog
(Canis familiaris)
Mammalia THAP11 33 34
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Thap11 33 16 34
  • 88.2 (n)
oppossum
(Monodelphis domestica)
Mammalia THAP11 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THAP11 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP11 34
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii thap11 33 34
  • 72.36 (n)
wufa14e04 33
Species where no ortholog for THAP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP11 Gene

ENSEMBL:
Gene Tree for THAP11 (if available)
TreeFam:
Gene Tree for THAP11 (if available)

Paralogs for THAP11 Gene

No data available for Paralogs for THAP11 Gene

Variants for THAP11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for THAP11 Gene

THA11_HUMAN-Q96EK4
The length of the poly-Gln region is variable in the population.

Sequence variations from dbSNP and Humsavar for THAP11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000978795 -- 67,842,871(+) GCAGC(A/G)GCAAC intron-variant, reference, missense
rs1001019773 -- 67,842,406(+) CGCCG(A/G)GCGGG intron-variant, utr-variant-5-prime
rs1002196565 -- 67,843,147(+) TGCAG(C/T)CGCAG intron-variant, reference, missense
rs1002994345 -- 67,840,621(+) GAAAA(G/T)ATAAC intron-variant, upstream-variant-2KB
rs1003022008 -- 67,840,405(+) GACAA(A/G)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THAP11 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV loss 19592680
nsv522852 CNV gain 19592680

Variation tolerance for THAP11 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP11

Disorders for THAP11 Gene

Relevant External Links for THAP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP11

No disorders were found for THAP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP11 Gene

Publications for THAP11 Gene

  1. NMR studies of a new family of DNA binding proteins: the THAP proteins. (PMID: 23306615) Gervais V … Milon A (Journal of biomolecular NMR 2013) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 60
  4. Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N … Muramatsu M (Nature biotechnology 1998) 3 4 60
  5. Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. (PMID: 8325628) Li SH … Ross CA (Genomics 1993) 2 3 60

Products for THAP11 Gene

Sources for THAP11 Gene

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