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Aliases for THAP11 Gene

Aliases for THAP11 Gene

  • THAP Domain Containing 11 2 3
  • HRIHFB2206 3
  • CTG-B43a 3
  • CTG-B45d 3
  • RONIN 3

External Ids for THAP11 Gene

Previous GeneCards Identifiers for THAP11 Gene

  • GC16U900023
  • GC16P067652
  • GC16P066433
  • GC16P067876
  • GC16P053749

Summaries for THAP11 Gene

Entrez Gene Summary for THAP11 Gene

  • The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

GeneCards Summary for THAP11 Gene

THAP11 (THAP Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for THAP11 Gene

  • Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP11 Gene

Genomics for THAP11 Gene

Regulatory Elements for THAP11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP11 Gene

Chromosome:
16
Start:
67,842,082 bp from pter
End:
67,844,195 bp from pter
Size:
2,114 bases
Orientation:
Plus strand

Genomic View for THAP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP11 Gene

Proteins for THAP11 Gene

  • Protein details for THAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK4-THA11_HUMAN
    Recommended name:
    THAP domain-containing protein 11
    Protein Accession:
    Q96EK4
    Secondary Accessions:
    • A4UCT5
    • A8K002
    • O94795

    Protein attributes for THAP11 Gene

    Size:
    314 amino acids
    Molecular mass:
    34455 Da
    Quaternary structure:
    • Interacts (via coiled coil domain) with HCFC1.

    Three dimensional structures from OCA and Proteopedia for THAP11 Gene

neXtProt entry for THAP11 Gene

Proteomics data for THAP11 Gene at MOPED

Post-translational modifications for THAP11 Gene

  • Ubiquitination at Lys 28 and Lys 38
  • Modification sites at PhosphoSitePlus

Other Protein References for THAP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THAP11 (THAP11)

No data available for DME Specific Peptides for THAP11 Gene

Domains & Families for THAP11 Gene

Gene Families for THAP11 Gene

Protein Domains for THAP11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP11 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EK4

UniProtKB/Swiss-Prot:

THA11_HUMAN :
  • Belongs to the THAP11 family.
  • Contains 1 THAP-type zinc finger.
Family:
  • Belongs to the THAP11 family.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP11: view

Function for THAP11 Gene

Molecular function for THAP11 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

Gene Ontology (GO) - Molecular Function for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IDA 23306615
GO:0005515 protein binding IPI 18585351
GO:0008270 zinc ion binding IDA 23306615
genes like me logo Genes that share ontologies with THAP11: view
genes like me logo Genes that share phenotypes with THAP11: view

Animal Models for THAP11 Gene

MGI Knock Outs for THAP11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for THAP11 Gene

Localization for THAP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP11 Gene

Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP11 Gene COMPARTMENTS Subcellular localization image for THAP11 gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with THAP11: view

Pathways & Interactions for THAP11 Gene

SuperPathways for THAP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with THAP11: view

No data available for Pathways by source and SIGNOR curated interactions for THAP11 Gene

Drugs & Compounds for THAP11 Gene

No Compound Related Data Available

Transcripts for THAP11 Gene

mRNA/cDNA for THAP11 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(146) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THAP11 Gene

THAP domain containing 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP11 Gene

No ASD Table

Relevant External Links for THAP11 Gene

GeneLoc Exon Structure for
THAP11
ECgene alternative splicing isoforms for
THAP11

Expression for THAP11 Gene

mRNA expression in normal human tissues for THAP11 Gene

Protein differential expression in normal tissues from HIPED for THAP11 Gene

This gene is overexpressed in Lung (49.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THAP11 Gene



SOURCE GeneReport for Unigene cluster for THAP11 Gene Hs.632200

genes like me logo Genes that share expression patterns with THAP11: view

Protein tissue co-expression partners for THAP11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP11 Gene

Orthologs for THAP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP11 36
  • 99 (a)
OneToOne
THAP11 35
  • 98.82 (n)
  • 99.68 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP11 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thap11 36
  • 95 (a)
OneToOne
Thap11 16
Thap11 35
  • 88.2 (n)
  • 95.08 (a)
oppossum
(Monodelphis domestica)
Mammalia THAP11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP11 36
  • 97 (a)
OneToOne
THAP11 35
  • 88.71 (n)
  • 94.19 (a)
cow
(Bos Taurus)
Mammalia THAP11 36
  • 97 (a)
OneToOne
THAP11 35
  • 88.78 (n)
  • 93.73 (a)
rat
(Rattus norvegicus)
Mammalia Thap11 35
  • 89.18 (n)
  • 96.1 (a)
lizard
(Anolis carolinensis)
Reptilia THAP11 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii thap11 36
  • 51 (a)
OneToOne
wufa14e04 35
thap11 35
  • 72.36 (n)
  • 76.22 (a)
Species with no ortholog for THAP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP11 Gene

ENSEMBL:
Gene Tree for THAP11 (if available)
TreeFam:
Gene Tree for THAP11 (if available)

Paralogs for THAP11 Gene

No data available for Paralogs for THAP11 Gene

Variants for THAP11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for THAP11 Gene

Q96EK4-THA11_HUMAN
The length of the poly-Gln region is variable in the population

Structural Variations from Database of Genomic Variants (DGV) for THAP11 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294

Variation tolerance for THAP11 Gene

Residual Variation Intolerance Score: 26.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP11 Gene

HapMap Linkage Disequilibrium report
THAP11

No data available for Sequence variations from dbSNP and Humsavar for THAP11 Gene

Disorders for THAP11 Gene

Relevant External Links for THAP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP11
genes like me logo Genes that share disorders with THAP11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP11 Gene

Publications for THAP11 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 67
  2. Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. (PMID: 8325628) Li S.H. … Ross C.A. (Genomics 1993) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells. (PMID: 24637716) Kong X.Z. … Yang X.M. (PLoS ONE 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for THAP11 Gene

Sources for THAP11 Gene

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