THAP11 Gene
protein-coding GIFtS: 47
GCID: GC16P067876
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|
THAP domain containing 11
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Aliases
for THAP11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THAP Domain Containing 111 2 | | CTG-B43a1 2 | | CTG-B45d1 2 | | HRIHFB22061 | | RONIN2 | | THAP Domain-Containing Protein 112 |
Export aliases for THAP11 gene to outside databasesPrevious GC identifers: GC16U900023 GC16P067652 GC16P066433 GC16P053749 |
Summaries
for THAP11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THAP11:
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has strikingsimilarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: THA11_HUMAN, Q96EK4Function: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem(ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directlybinding to key genetic loci and recruiting epigenetic modifiers (By similarity)
|
Genomic Views
for THAP11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THAP11 gene promoter:
Nkx3-1 Nkx3-1 v4 ATF-2 MyoD Nkx3-1 v1 Egr-4 GATA-2 CRE-BP1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for THAP11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1THAP11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P067876: view genomic region
(about GC identifiers)
Start:
|
67,876,213 bp from pter |
End:
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67,878,098 bp from pter |
Size:
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1,886 bases |
Orientation:
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plus strand |
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Proteins
for THAP11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THA11_HUMAN, Q96EK4 (See
protein sequence)Recommended Name: THAP domain-containing protein 11 Size: 314 amino acids; 34455 Da
Subunit: Interacts (via coiled coil domain) with HCFC1 (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=May be regulated by shuttling of the protein between thecytoplasm and nucleus (By similarity)
1 PDB 3D structure from  and Proteopedia  for THAP11:2LAU (3D)
Secondary accessions: A4UCT5 A8K002 O94795Explore the universe of human proteins at neXtProt for THAP11: NX_Q96EK4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EK4
THAP11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065190.2
ENSEMBL proteins: ENSP00000304689
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
THAP11 for ontologies About GeneDecksing
THAP11 Antibody Products:
Assay Products for THAP11: |
Protein
Domains /
Families
for THAP11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THAP11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96EK4ProtoNet protein and cluster: Q96EK4 UniProtKB/Swiss-Prot: THA11_HUMAN, Q96EK4Similarity: Belongs to the THAP11 familySimilarity: Contains 1 THAP-type zinc finger |
Function
for THAP11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THA11_HUMAN, Q96EK4Function: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem(ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directlybinding to key genetic loci and recruiting epigenetic modifiers (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP11 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
THAP11 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for THAP11:
Animal Models:
Mouse knock-out Thap11tm1.1Tpz for THAP11
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Thap11):
THAP11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for THAP11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for THAP11 (Q96EK41, 2, 3 ENSP000003046894) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
THAP11 for ontologies About GeneDecksing
|
Drugs & Compounds
for THAP11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THAP11
Search CenterWatch for drugs/clinical trials and news about THAP11 / THA11
|
Transcripts
for THAP11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THAP11 gene: NM_020457.2 Unigene Cluster for THAP11: THAP domain containing 11 Hs.632200 [show with all ESTs]Unigene Representative Sequence: NM_0204571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000303596(uc002euo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THAP11 (NM_020457) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP11 |
Additional cDNA sequence: AB015338.1 AK289367.1 BC012182.1 EF036502.1 EU869208.1 L10378.1 L10379.1 12 DOTS entries: DT.80101932 DT.99990115 DT.100764872 DT.452549 DT.100776509 DT.120718372 DT.120718408 DT.92431075 DT.95291057 DT.95359964 DT.120718478 DT.97792421 24/146 AceView cDNA sequences (see all 146): CA436710 AI478862 BQ928136 AA004727 BM044187 BE388513 BE271999 AI364366 AI678308 BU541805 AI625665 BM423331 BU622385 BU741133 AA903311 AI862156 BQ961942 BU543680 AI206144 BU079093 BM005962 BE048930 AI885770 BQ012892
GeneLoc Exon Structure
|
Expression
for THAP11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THAP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTCCTTC
About this image
See THAP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP11
SOURCE GeneReport for Unigene cluster: Hs.632200
SABiosciences Custom PCR Arrays for THAP11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THAP11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP11 |
Orthologs
for THAP11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for THAP11 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Thap111 , 5 |
THAP domain containing 111, 5 |
88.31(n)1
95.08(a)1 |
|
8 (53.05 cM)5
590161 NM_021513.21 NP_067488.11
1058551035 |
chicken
(Gallus gallus) |
Aves |
THAP116 |
Uncharacterized protein |
66(a) |
1 ↔ 1 |
11(874570-875085) |
lizard
(Anolis carolinensis) |
Reptilia |
THAP116 |
-- |
66(a) |
1 ↔ 1 |
GL343295.1(667695-669360) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa14e042 |
Danio rerio cDNA clone MGC65871 IMAGE6800403, complete more |
81.9(n) |
|
AY398362.1 |
ENSEMBL Gene Tree for THAP11 (if available)
TreeFam Gene Tree for THAP11 (if available) |
Paralogs
for THAP11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THAP11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: THA11_HUMAN, Q96EK4Polymorphism: The length of the poly-Gln region is variable in the population
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP11 (67876213 - 67878098 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THAP11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP11 |
|
Disorders
/ Diseases
for THAP11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 THAP11 for disorders About MalaCards
THAP11 for disorders About GeneDecksing
OMIM gene information: 609119
OMIM disorders: --
Export disorders for THAP11 gene to outside databases
|
Publications
for THAP11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THAP11 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with THAP11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
- Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (1998)
- Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. (PubMed id 8325628)1, 3 Li S.-H.... Ross C.A. (1993)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. (PubMed id 21400515)1 Nakamura S....Ohnishi K. (2012)
- THAP11, a novel binding protein of PCBP1, negatively r egulates CD44 alternative splicing and cell invasion in a human hepatoma cell li ne. (PubMed id 22673507)1 Lian W.X....Yang X.M. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function. (PubMed id 22371484)1 Parker J.B....Chakravarti D. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for THAP11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THAP11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THAP11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THAP11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THAP11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THAP11 gene:
Search GeneIP for patents involving THAP11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for THAP11 | | OriGene shRNA RFP for THAP11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THAP11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP11 | | | OriGene Protein Over-expression Lysate for THAP11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THAP11 | | OriGene 3'-UTR Clone for THAP11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THAP11 | | OriGene Custom Protein Services for THAP11 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THAP11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP11 |
| |
 |  |  |  | |
| | Antibodies & Assays for THAP11 |
| | | | Search Tocris compounds for THAP11 |
| |  |  |  |  | | | | |
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 | | | THAP11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP11 |
|  |  |  | | | | ThermoFisher Antibody for THAP11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP11 |
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