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Aliases for THAP10 Gene

Aliases for THAP10 Gene

  • THAP Domain Containing 10 2 3 5

External Ids for THAP10 Gene

Previous GeneCards Identifiers for THAP10 Gene

  • GC15M068749
  • GC15M068889
  • GC15M068960
  • GC15M071173
  • GC15M048009

Summaries for THAP10 Gene

Entrez Gene Summary for THAP10 Gene

  • This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]

GeneCards Summary for THAP10 Gene

THAP10 (THAP Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP10 Gene

Genomics for THAP10 Gene

Regulatory Elements for THAP10 Gene

Enhancers for THAP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F071745 1.3 Ensembl ENCODE 18.4 -854.6 -854632 3.5 PKNOX1 MLX SIN3A FEZF1 ZNF2 ZNF143 FOS ZHX2 ZNF592 SREBF1 LOC105370888 ARIH1 ENSG00000260672 THAP10 ENSG00000261187 LRRC49 LOC105370887 HEXA NR2E3 RPL17P39
GH15F070790 1.6 FANTOM5 Ensembl ENCODE 10.2 +98.9 98944 6.3 ZNF493 ZFP64 SIN3A ZNF121 KLF7 ZNF548 FOS ZNF202 SP3 JUNB RPL17P39 LARP6 RPL29P30 UACA LRRC49 THAP10 ENSG00000259744 ENSG00000259452
GH15F071442 1.2 Ensembl ENCODE 10 -553.3 -553339 6.6 HDGF PKNOX1 SIN3A FEZF1 YBX1 ZNF2 RAD21 ZNF48 ZNF366 SCRT2 RPL17P39 THAP10 GC15P071396 GC15P071507
GH15F071042 1.1 FANTOM5 ENCODE 10.1 -151.0 -151006 3.4 SIX4 ESRRA PKNOX1 JUN FEZF1 YBX1 CTBP1 MTA3 GATA3 SCRT2 THAP10 RPL5P3
GH15F071328 1.1 Ensembl ENCODE 10 -440.4 -440449 10.4 PKNOX1 KLF17 YBX1 RAD21 YY1 POLR3A SCRT2 RCOR1 FOS ZNF362 THAP10 THSD4 PIR52996 RPL17P39
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP10 on UCSC Golden Path with GeneCards custom track

Promoters for THAP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001453600 285 2200 ARID4B SIN3A DMAP1 ZNF2 YY1 DEK ZNF263 SP3 NFYC REST

Genomic Location for THAP10 Gene

70,881,342 bp from pter
70,892,785 bp from pter
11,444 bases
Minus strand

Genomic View for THAP10 Gene

Genes around THAP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP10 Gene

Proteins for THAP10 Gene

  • Protein details for THAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • B2R8R0

    Protein attributes for THAP10 Gene

    257 amino acids
    Molecular mass:
    28351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THAP10 Gene

Post-translational modifications for THAP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP10 Gene

Domains & Families for THAP10 Gene

Gene Families for THAP10 Gene

Protein Domains for THAP10 Gene


Suggested Antigen Peptide Sequences for THAP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP10: view

Function for THAP10 Gene

Gene Ontology (GO) - Molecular Function for THAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP10: view

Phenotypes for THAP10 Gene

genes like me logo Genes that share phenotypes with THAP10: view

Animal Model Products

miRNA for THAP10 Gene

miRTarBase miRNAs that target THAP10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP10 Gene

Localization for THAP10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP10 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP10 Gene

Pathways & Interactions for THAP10 Gene

SuperPathways for THAP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP10 Gene


No data available for Pathways by source and SIGNOR curated interactions for THAP10 Gene

Transcripts for THAP10 Gene

mRNA/cDNA for THAP10 Gene

Unigene Clusters for THAP10 Gene

THAP domain containing 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP10 Gene

No ASD Table

Relevant External Links for THAP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP10 Gene

Protein differential expression in normal tissues from HIPED for THAP10 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP10 Gene

Protein tissue co-expression partners for THAP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THAP10 Gene:


SOURCE GeneReport for Unigene cluster for THAP10 Gene:

genes like me logo Genes that share expression patterns with THAP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP10 Gene

Orthologs for THAP10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for THAP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THAP10 34 35
  • 99.09 (n)
(Canis familiaris)
Mammalia THAP10 34 35
  • 79.5 (n)
(Monodelphis domestica)
Mammalia THAP10 35
  • 70 (a)
(Bos Taurus)
Mammalia THAP10 35
  • 42 (a)
Species where no ortholog for THAP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP10 Gene

Gene Tree for THAP10 (if available)
Gene Tree for THAP10 (if available)

Paralogs for THAP10 Gene

No data available for Paralogs for THAP10 Gene

Variants for THAP10 Gene

Sequence variations from dbSNP and Humsavar for THAP10 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111422634 -- 70,883,709(+) AGAAG(C/T)ATGAT intron-variant
rs111755559 -- 70,886,642(+) GCAGG(C/T)GGGTC intron-variant
rs111981438 -- 70,882,241(+) AAAAA(A/C)AAGGT intron-variant, utr-variant-3-prime
rs112633788 -- 70,886,832(+) CTGCA(C/G)TCCAG intron-variant
rs112873014 -- 70,886,217(+) TAGGA(C/T)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP10 Gene

Variant ID Type Subtype PubMed ID
nsv827381 CNV loss 20364138
dgv153n21 CNV loss 19592680

Variation tolerance for THAP10 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP10 Gene

Disorders for THAP10 Gene

Relevant External Links for THAP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THAP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP10 Gene

Publications for THAP10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for THAP10 Gene

Sources for THAP10 Gene

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