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Aliases for THAP10 Gene

Aliases for THAP10 Gene

  • THAP Domain Containing 10 2 3

External Ids for THAP10 Gene

Previous GeneCards Identifiers for THAP10 Gene

  • GC15M068749
  • GC15M068889
  • GC15M068960
  • GC15M071173
  • GC15M048009

Summaries for THAP10 Gene

Entrez Gene Summary for THAP10 Gene

  • This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010]

GeneCards Summary for THAP10 Gene

THAP10 (THAP Domain Containing 10) is a Protein Coding gene. Diseases associated with THAP10 include breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP10 Gene

Genomics for THAP10 Gene

Regulatory Elements for THAP10 Gene

Genomic Location for THAP10 Gene

Start:
70,881,342 bp from pter
End:
70,892,785 bp from pter
Size:
11,444 bases
Orientation:
Minus strand

Genomic View for THAP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP10 Gene

Proteins for THAP10 Gene

  • Protein details for THAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2Z0-THA10_HUMAN
    Recommended name:
    THAP domain-containing protein 10
    Protein Accession:
    Q9P2Z0
    Secondary Accessions:
    • B2R8R0

    Protein attributes for THAP10 Gene

    Size:
    257 amino acids
    Molecular mass:
    28351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THAP10 Gene

Proteomics data for THAP10 Gene at MOPED

Post-translational modifications for THAP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP10 Gene

Domains for THAP10 Gene

Gene Families for THAP10 Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for THAP10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2Z0

UniProtKB/Swiss-Prot:

THA10_HUMAN :
  • Q9P2Z0
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP10: view

Function for THAP10 Gene

Gene Ontology (GO) - Molecular Function for THAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP10: view

Phenotypes for THAP10 Gene

GenomeRNAi human phenotypes for THAP10:
genes like me logo Genes that share phenotypes with THAP10: view

miRNA for THAP10 Gene

miRTarBase miRNAs that target THAP10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THAP10 Gene

Localization for THAP10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP10 Gene COMPARTMENTS Subcellular localization image for THAP10 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP10 Gene

Pathways for THAP10 Gene

SuperPathways for THAP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP10 Gene

None

No data available for Pathways by source for THAP10 Gene

Transcripts for THAP10 Gene

mRNA/cDNA for THAP10 Gene

(53) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THAP10 Gene

THAP domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP10 Gene

No ASD Table

Relevant External Links for THAP10 Gene

GeneLoc Exon Structure for
THAP10
ECgene alternative splicing isoforms for
THAP10

Expression for THAP10 Gene

mRNA expression in normal human tissues for THAP10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THAP10 Gene

SOURCE GeneReport for Unigene cluster for THAP10 Gene Hs.591123

genes like me logo Genes that share expressions with THAP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP10 Gene

Orthologs for THAP10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for THAP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP10 35
  • 99.09 (n)
  • 99.22 (a)
THAP10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THAP10 36
  • 42 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP10 35
  • 79.5 (n)
  • 76.19 (a)
THAP10 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THAP10 36
  • 70 (a)
OneToOne
Species with no ortholog for THAP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP10 Gene

ENSEMBL:
Gene Tree for THAP10 (if available)
TreeFam:
Gene Tree for THAP10 (if available)

Paralogs for THAP10 Gene

No data available for Paralogs for THAP10 Gene

Variants for THAP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for THAP10 Gene

Variant ID Type Subtype PubMed ID
dgv153n21 CNV Loss 19592680
nsv827381 CNV Loss 20364138

Relevant External Links for THAP10 Gene

HapMap Linkage Disequilibrium report
THAP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for THAP10 Gene

Disorders for THAP10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for THAP10 Gene including...

Search for THAP10 Gene in MalaCards »
genes like me logo Genes that share disorders with THAP10: view

No data available for UniProtKB/Swiss-Prot for THAP10 Gene

Publications for THAP10 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer. (PMID: 18575747) De Souza Santos E. … Nagai M.A. (Int. J. Oncol. 2008) 3

Products for THAP10 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate THAP10
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP10
  • Block miRNA regulation of THAP10 using miScript Target Protectors

Sources for THAP10 Gene

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