THAP10 Gene
protein-coding GIFtS: 44
GCID: GC15M071173
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THAP domain containing 10
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Aliases
for THAP10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THAP Domain Containing 101 2 | | THAP Domain-Containing Protein 102 |
Export aliases for THAP10 gene to outside databasesPrevious GC identifers: GC15M068749 GC15M068889 GC15M068960 GC15M048009 |
Summaries
for THAP10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THAP10:
This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. TheThanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of abidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breastcancer. (provided by RefSeq, Nov 2010)
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Genomic Views
for THAP10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THAP10 gene promoter:
RFX1 RP58 Elk-1 AP-1 Nkx2-2 Bach2 C/EBPalpha FOXO1a ZID FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for THAP10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.32THAP10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M071173: view genomic region
(about GC identifiers)
Start:
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71,173,681 bp from pter |
End:
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71,185,124 bp from pter |
Size:
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11,444 bases |
Orientation:
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minus strand |
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Proteins
for THAP10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THA10_HUMAN, Q9P2Z0 (See
protein sequence)Recommended Name: THAP domain-containing protein 10 Size: 257 amino acids; 28351 Da
Secondary accessions: B2R8R0Explore the universe of human proteins at neXtProt for THAP10: NX_Q9P2Z0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2Z0
THAP10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064532.1
ENSEMBL proteins: ENSP00000249861 ENSP00000453920
Human Recombinant Protein Products:
THAP10 Antibody Products:
Assay Products for THAP10: |
Protein
Domains /
Families
for THAP10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THAP10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P2Z0ProtoNet protein and cluster: Q9P2Z0 UniProtKB/Swiss-Prot: THA10_HUMAN, Q9P2Z0Similarity: Contains 1 THAP-type zinc finger |
Function
for THAP10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for THAP10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP10 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
THAP10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for THAP10:
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Pathways & Interactions
for THAP10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP10
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for THAP10 (Q9P2Z02, 3 ENSP000002498614) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for THAP10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THAP10
Search CenterWatch for drugs/clinical trials and news about THAP10 / THA10
|
Transcripts
for THAP10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THAP10 gene: NM_020147.3 Unigene Cluster for THAP10: THAP domain containing 10 Hs.591123 [show with all ESTs]Unigene Representative Sequence: NM_0201472 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249861(uc002asv.3) ENST00000560604
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THAP10 (NM_020147) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP10 |
Additional cDNA sequence: AK313472.1 AL360202.1 BC027857.1 BC072414.1 4 DOTS entries: DT.215309 DT.210264 DT.100790193 DT.92034847 24/53 AceView cDNA sequences (see all 53): NM_020147 AA411400 BC027857 CR616569 BM728582 AI338041 BX091586 BP361383 BM715616 BM674059 BE906653 CR619402 BI836458 AI648560 AW296810 BC072414 AL562734 AI798786 BF979815 BQ424963 AI810129 AL360202 AL526710 BI334727
GeneLoc Exon Structure
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Expression
for THAP10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THAP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See THAP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP10
SOURCE GeneReport for Unigene cluster: Hs.591123
SABiosciences Custom PCR Arrays for THAP10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat THAP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP10 |
Orthologs
for THAP10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for THAP10 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
soybean
(Glycine max) |
eudicotyledons |
467273812 |
-- |
93.48(n) |
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Species with no ortholog for THAP10
ENSEMBL Gene Tree for THAP10 (if available)
TreeFam Gene Tree for THAP10 (if available) |
Paralogs
for THAP10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THAP10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP10 (71173681 - 71185124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for THAP10
2 CNVs: 87727 87725 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP10 |
|
Disorders
/ Diseases
for THAP10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THAP10 for disorders About GeneDecksing
OMIM gene information: 612538
OMIM disorders: --
1  disease for THAP10: About MalaCardsbreast cancer
Export disorders for THAP10 gene to outside databases
|
Publications
for THAP10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THAP10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with THAP10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer. (PubMed id 18575747)1 De Souza Santos E....Nagai M.A. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for THAP10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing THAP10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THAP10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THAP10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THAP10 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for THAP10 gene:
Search GeneIP for patents involving THAP10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THAP10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THAP10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP10 | | | OriGene Protein Over-expression Lysate for THAP10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THAP10 | | OriGene 3'-UTR Clone for THAP10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | THAP10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP10 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP10 |
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