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THADA Gene

protein-coding   GIFtS: 54

GC02M043369
thyroid adenoma associated
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ21877 1, 2
FLJ44016 2
FLJ44876 2
FLJ77530 2
GITA 1, 2, 3
KIAA1767 1, 2, 3, 5
Descriptions
Gene inducing thyroid adenomas protein 3
death receptor-interacting protein 2
thyroid adenoma associated 2
External Ids
HGNC: 192171
Entrez Gene: 638922
UniProtKB: Q6YHU63
Ensembl: ENSG000001159707
Search outside databases for aliases for THADA gene

Previous GC identifer: GC02M043432

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the THADA gene  

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

THADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M043369:     (about GC identifiers)

Start:
43,311,479 bp from pter
End:
43,676,689 bp from pter
Size:
365,211 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6 (See protein sequence)
Recommended Name: Thyroid adenoma-associated protein  
Size: 1953 amino acids; 219607 Da
Secondary accessions: A8K1V8 Q3KR04 Q53RC6 Q53TB2 Q6YHU2 Q6ZU38 Q8TAU8 Q96I88 Q9BZF7 Q9C096 Q9H6U0
Q9H6W7
Alternative splicing: 5 isoforms:  Q6YHU6-1   Q6YHU6-2   Q6YHU6-3   Q6YHU6-4   Q6YHU6-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001077422.1  NP_071348.3  


    ENSEMBL proteins: 
    ENSP00000385469 ENSP00000384266 ENSP00000381647 ENSP00000384172 ENSP00000386112 ENSP00000385003 
    ENSP00000387029 ENSP00000385441 ENSP00000367903 ENSP00000349464 ENSP00000385995 ENSP00000386088 
    ENSP00000331105 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for THADA: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for THADA

    Assays for THADA: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR019442 DUF2428_death-receptor-like


       GeneDecks  THADA for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6YHU6

    ProtoNet protein and cluster: Q6YHU6

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
    Similarity: Belongs to the THADA family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (THADA)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (THADA)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022065

                  Applied Biosystems Silencer® siRNAs for THADA

                  Sigma-Aldrich siRNA for THADA  
                         Sigma-Aldrich shRNA for THADA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for THADA
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083953
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083953
                                     untagged cDNA clones in CMV expression vector (see all 4): AK025445 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001083953

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/8 Interacting proteins for THADA (ENSP000003311053) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGAENSP000003698203STRING (score=.999)
    CAMK1DENSP000003681243STRING (score=.736)
    ARMC9ENSP000002584173STRING (score=.733)
    TSPAN8ENSP000002478293STRING (score=.73)
    NOTCH2ENSP000002566463STRING (score=.714)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for THADA

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (THADA)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (THADA)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_022065

                  Sigma-Aldrich siRNA for THADA  
                         Sigma-Aldrich shRNA for THADA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001083953  NM_022065  

    REFSEQ mRNAs for THADA gene (2 alternative transcripts): 

    NM_001083953.1   NM_022065.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001083953  NM_022065  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083953
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083953
                                     untagged cDNA clones in CMV expression vector (see all 4): AK025445 

    Additional cDNA sequence: 

    AB051554.2 AF323176.1 AK025530.1 AK126004.1 AK126824.1 AK290023.1 AK307915.1 AL832141.1 
    AY149629.1 BC007743.1 BC025773.1 BC037847.1 BC037990.2 BC105976.1 BX641038.1 BX648155.1 

    21 DOTS entries:

    DT.97840593  DT.312798  DT.101982081  DT.99927036  DT.101975394  DT.95374335  DT.101969018  DT.97798476 
    DT.91920751  DT.97771230  DT.120987317  DT.120987385  DT.120987393  DT.100647752  DT.100728845  DT.101982083 
    DT.65284647  DT.75131153  DT.97836994  DT.101985249  DT.40127345 

    24/152 AceView cDNA sequences (see all 152 ):

    CA435816 BG751312 BM717060 BC007743 AW250225 AI144206 BQ652973 AY149633 
    AI338592 CA312282 CK818805 BE465537 BM675242 BM800587 BF436747 BM983209 
    AF323176 AA770594 BQ576266 BM457244 BC025773 BQ900649 BX641038 NM_022065 

    highest scoring ESTs for THADA:

    AB051554 AL832141 AY149629 AY149633 BC037990 BM800587 BQ889331 BX641038 BX648155 CD643243 

    Unigene Cluster for THADA:

    Thyroid adenoma associated
    Hs.369592  [show with all ESTs]
    Unigene Representative Sequence: BX641038


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THADA (see all 10 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                    -                                                                                                                 -           -         
    SP2:                                                                                                                                      -           -         
    SP3:                    -                                                     -                                                           -           -         
    SP4:                    -                                                     -                                                           -           -         
    SP5:                    -                                                     -                                                           -           -         

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
    SP1:                                            -     -                             -     -                                                         
    SP2:                                            -     -                             -     -                                                         
    SP3:                                      -     -     -     -                       -     -                                                         
    SP4:                                            -     -                                                                                             
    SP5:                                            -     -                                                                                             

    About this scheme

    ECgene alternative splicing isoforms for THADA

    13 Ensembl transcripts including schematic representations:
    ENST00000403856  ENST00000404790  ENST00000398653  ENST00000408045  ENST00000407351  ENST00000402796  
    ENST00000409142  ENST00000402360  ENST00000378636  ENST00000356975  ENST00000405006  ENST00000405975  
    ENST00000330266  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    THADA expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for THADA

    1 / 2 / 3

    11 probe-sets matching THADA gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    54632_at2, 3 U133-B 1 1.00 1.00 0.77 1.16 AI286226 0.40 1.00 0.76 1
    88722_at2, 3 U95-D 1 0.94 1.00 0.69 1.01 AI669469 0.60 1.00 0.82 1
    67138_at2, 3 U95-D 1 0.81 1.00 0.92 0.84 AI338592 0.60 1.00 0.82 1

    54632_at2, 3 U133-A 1 1.00 1.00 -- -- AI286226 0.40 1.00 0.76 1

    220212_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022065 0.60 1.00 0.82 1

    54632_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    220212_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554492_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554493_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1558306_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1566889_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  THADA for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGAACATAA

    SOURCE GeneReport for Unigene cluster: Hs.369592

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
    Tissue specificity: Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis,
    thymus, small intestine and stomach

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for THADA gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    THADA1   -- thyroid adenoma associated 99.51(n)
    99.18(a)
    737308  XM_001141732.1  XP_001141732.1 
    rat
    (Rattus norvegicus)
    Thada1   -- thyroid adenoma associated 82.93(n)
    79.83(a)
    313865  XM_233829.4  XP_233829.4 
    mouse
    (Mus musculus)
    Thada1, 5 175
    thyroid adenoma associated1, 5 81.77(n)1
    79.01(a)1
    2401741  XM_619495.41  XP_619495.31 
     AK0445505  AK0783535  (see all 12)
    chicken
    (Gallus gallus)
    THADA1   -- thyroid adenoma associated 63.68(n)
    59.13(a)
    421398  XM_419454.2  XP_419454.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    (YMR259C)4 13(788882-784620) Putative protein of unknown function; green fluorescent more   -- 855301  NP_013986.1 
    About this table        Species with no ortholog for THADA

    ENSEMBL Gene Tree for THADA
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1707 NCBI SNPs in THADA are shown (see all 1707 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 571)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs173342471,2
    C,F,H43401176(+) ACATGG/AATTTT 2 S/P mis1 ese312Minor allele frequency- A:0.01NA EU EA WA 1044
    rs75785971,2
    C,F,H43586327(+) CATTGT/CTATTT 2 A/T mis111Minor allele frequency- C:0.11EU EA WA NA 982
    rs170306481,2
    C,F,H43372347(+) CACACA/GTGTCT 2 C/R mis1 ese312Minor allele frequency- G:0.06NA EU EA WA 1056
    rs170310561,2
    C,F,H43651123(+) AAGTAC/TCTGAG 2 V/I mis1 ese312Minor allele frequency- N:0.00NA EA EU WA 1040
    rs102101911,2
    C,F,H43671581(+) CTTTCT/CCCAGC 2 G/E mis18Minor allele frequency- C:0.00EU EA WA 838
    rs339799341,2
    C,F43478688(+) CAGAGT/ATCGAA 2 S/T mis13Minor allele frequency- A:0.27NA 246
    rs101769801,2
    F,H43678077(+) ATAGTA/GAGAAA 2 -- ng314Minor allele frequency- G:0.01EU EA WA 352
    rs357207611,2
    C,F43373481(-) CTTCTG/ACAAGG 2 Y/C mis15Minor allele frequency- A:0.07NA EU EA WA 494
    rs130218941,2
    A,C,F,H43657733(+) ATGCTT/CCCGTT 2 G/G syn17Minor allele frequency- C:0.39EU EA WA NA 552
    rs170310741,2
    C,F,H43655415(+) GGGACG/AAAATC 2 F/F syn1 ese312Minor allele frequency- A:0.04NA EU EA WA 1056
    About this table

    HapMap Linkage Disequilibrium images for THADA (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611800

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
  • Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas.
    Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from
    chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably
    result in truncated THADA proteins
  • Human Genome Epidemiology Navigator: THADA (9 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for THADA gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 63892 HGNC: 19217 AceView: THADA Ensembl:ENSG00000115970 euGenes: HUgn63892
    ECgene: THADA H-InvDB: THADA
    (According to HUGE)
    About This Section

    HUGE: KIAA1767
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for THADA:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for THADA Browse antibodies at Sigma-Aldrich
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     Lentivirus-delivered shRNAs for THADA Browse small molecules at Sigma-Aldrich
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