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Aliases & Descriptions for THADA
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ21877 1 , 2 FLJ44016 2 FLJ44876 2 FLJ77530 2 GITA 1 , 2 , 3 KIAA1767 1 , 2 , 3 , 5
Descriptions Gene inducing thyroid adenomas protein 3 death receptor-interacting protein 2 thyroid adenoma associated 2
Search outside databases for aliases for THADA genePrevious GC identifer: GC02M043432
Summaries for THADA (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for THADA
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the THADA gene Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21 THADA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M043369:
(about GC identifiers )
Start:
43,311,479 bp from pter
End:
43,676,689 bp from pter
Size:
365,211 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_022184.14 Proteins for THADA
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6 (See
protein sequence )Recommended Name: Thyroid adenoma-associated protein Size : 1953 amino acids; 219607 Da
Secondary accessions : A8K1V8 Q3KR04 Q53RC6 Q53TB2 Q6YHU2 Q6ZU38 Q8TAU8 Q96I88 Q9BZF7 Q9C096 Q9H6U0Q9H6W7 Alternative splicing : 5 isoforms : Q6YHU6-1 Q6YHU6-2 Q6YHU6-3 Q6YHU6-4 Q6YHU6-5
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001077422.1 NP_071348.3 ENSEMBL proteins: ENSP00000385469 ENSP00000384266 ENSP00000381647 ENSP00000384172 ENSP00000386112 ENSP00000385003 ENSP00000387029 ENSP00000385441 ENSP00000367903 ENSP00000349464 ENSP00000385995 ENSP00000386088 ENSP00000331105 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for THADA: Assays for THADA:
Protein
Domains/ Families for THADA(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q6YHU6 ProtoNet protein and cluster: Q6YHU6
1 Blocks protein family : IPB000357 HEAT repeat UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6 Similarity : Belongs to the THADA family
Gene Function for THADA
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_022065 Applied Biosystems Silencer ® siRNAs for THADA Sigma-Aldrich siRNA for THADA Sigma-Aldrich shRNA for THADA Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001083953                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001083953                                  untagged cDNA clones in CMV expression vector (see all 4 ): AK025445  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001083953 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005488 binding
IEA --
About this table
Pathways & Interactions for THADA
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Interacting proteins for THADA (ENSP00000331105 3 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
Drugs & Compounds for THADA (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for THADA
Transcripts for THADA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_022065 Sigma-Aldrich siRNA for THADA Sigma-Aldrich shRNA for THADA Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001083953 NM_022065
REFSEQ mRNAs for THADA gene (2 alternative transcripts): NM_001083953.1 NM_022065.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001083953 NM_022065
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001083953                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001083953                                  untagged cDNA clones in CMV expression vector (see all 4 ): AK025445  
Additional cDNA sequence: AB051554.2 AF323176.1 AK025530.1 AK126004.1 AK126824.1 AK290023.1 AK307915.1 AL832141.1 AY149629.1 BC007743.1 BC025773.1 BC037847.1 BC037990.2 BC105976.1 BX641038.1 BX648155.1
21 DOTS entries : DT.97840593 DT.312798 DT.101982081 DT.99927036 DT.101975394 DT.95374335 DT.101969018 DT.97798476 DT.91920751 DT.97771230 DT.120987317 DT.120987385 DT.120987393 DT.100647752 DT.100728845 DT.101982083 DT.65284647 DT.75131153 DT.97836994 DT.101985249 DT.40127345
24/152 AceView cDNA sequences (see all 152
):CA435816 BG751312 BM717060 BC007743 AW250225 AI144206 BQ652973 AY149633 AI338592 CA312282 CK818805 BE465537 BM675242 BM800587 BF436747 BM983209 AF323176 AA770594 BQ576266 BM457244 BC025773 BQ900649 BX641038 NM_022065
highest scoring ESTs for THADA :AB051554 AL832141 AY149629 AY149633 BC037990 BM800587 BQ889331 BX641038 BX648155 CD643243
Unigene Cluster for THADA: Thyroid adenoma associated Hs.369592 [show with all ESTs ] Unigene Representative Sequence: BX641038 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THADA (see all 10
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ SP1 :       -                                       -     -     SP2 :                                             -     -     SP3 :       -                   -                     -     -     SP4 :       -                   -                     -     -     SP5 :       -                   -                     -     -    
ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b SP1 :               -   -           -   -                     SP2 :               -   -           -   -                     SP3 :             -   -   -   -         -   -                     SP4 :               -   -                                 SP5 :               -   -                                
About this scheme ECgene alternative splicing isoforms for THADA 13 Ensembl transcripts including schematic representations : ENST00000403856
ENST00000404790
ENST00000398653
ENST00000408045
ENST00000407351
ENST00000402796
ENST00000409142
ENST00000402360
ENST00000378636
ENST00000356975
ENST00000405006
ENST00000405975
ENST00000330266
Expression for THADA
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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THADA expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for THADA 1 / 2 / 3
11 probe-sets matching THADA gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTGAACATAASOURCE GeneReport for Unigene cluster: Hs.369592 UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6 Tissue specificity : Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis,thymus, small intestine and stomach
Orthologs for THADA
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for THADA gene from 5 species
About this table Species with no ortholog for THADA ENSEMBL Gene Tree for THADA Paralogs for THADA (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for THADA (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for THADA (up to first 250kb)
Disorders & Mutations for THADA
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611800 UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas.Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived fromchromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probablyresult in truncated THADA proteins
Human Genome Epidemiology Navigator: THADA (9 documents)
Medical News for THADA (Possibly Related Articles in
Doctor's Guide )
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Publications for THADA (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for THADA gene (see all 20
):
Search for THADA
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing THADA
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing THADA
(According to HUGE )
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Specialized Databases showing THADA (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for THADA (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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