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Aliases for THADA Gene

Aliases for THADA Gene

  • Thyroid Adenoma Associated 2 3
  • Gene Inducing Thyroid Adenomas Protein 3 4
  • KIAA1767 4 6
  • GITA 3 4
  • Death Receptor-Interacting Protein 3
  • Thyroid Adenoma-Associated Protein 3

External Ids for THADA Gene

Summaries for THADA Gene

GeneCards Summary for THADA Gene

THADA (Thyroid Adenoma Associated) is a Protein Coding gene. Diseases associated with THADA include thyroid adenoma and adenoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THADA Gene

Genomics for THADA Gene

Genomic Location for THADA Gene

Start:
43,230,836 bp from pter
End:
43,596,046 bp from pter
Size:
365,211 bases
Orientation:
Minus strand

Genomic View for THADA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THADA Gene

Regulatory Elements for THADA Gene

Proteins for THADA Gene

  • Protein details for THADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YHU6-THADA_HUMAN
    Recommended name:
    Thyroid adenoma-associated protein
    Protein Accession:
    Q6YHU6
    Secondary Accessions:
    • A8K1V8
    • B7WNS6
    • Q3KR04
    • Q53RC6
    • Q53TB2
    • Q6YHU2
    • Q6ZU38
    • Q8IY32
    • Q8TAU8
    • Q96I88
    • Q9BZF7
    • Q9C096
    • Q9H6U0
    • Q9H6W7

    Protein attributes for THADA Gene

    Size:
    1953 amino acids
    Molecular mass:
    219607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15133.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15162.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for THADA Gene

neXtProt entry for THADA Gene

Proteomics data for THADA Gene at MOPED

Post-translational modifications for THADA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys702 and Lys1008

No data available for DME Specific Peptides for THADA Gene

Domains for THADA Gene

Protein Domains for THADA Gene

UniProtKB/Swiss-Prot:

THADA_HUMAN
Family:
  • Belongs to the THADA family.:
    • Q6YHU6
genes like me logo Genes that share domains with THADA: view

No data available for Gene Families for THADA Gene

Function for THADA Gene

Gene Ontology (GO) - Molecular Function for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THADA: view

Phenotypes for THADA Gene

genes like me logo Genes that share phenotypes with THADA: view

miRNA for THADA Gene

miRTarBase miRNAs that target THADA

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THADA Gene

Localization for THADA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THADA Gene COMPARTMENTS Subcellular localization image for THADA gene
Compartment Confidence
plasma membrane 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for THADA Gene

Pathways for THADA Gene

SuperPathways for THADA Gene

No Data Available

Gene Ontology (GO) - Biological Process for THADA Gene

None

No data available for Pathways by source for THADA Gene

Transcripts for THADA Gene

Unigene Clusters for THADA Gene

Thyroid adenoma associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THADA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9:
SP10: - -

Relevant External Links for THADA Gene

GeneLoc Exon Structure for
THADA
ECgene alternative splicing isoforms for
THADA

Expression for THADA Gene

mRNA expression in normal human tissues for THADA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THADA Gene

SOURCE GeneReport for Unigene cluster for THADA Gene Hs.369592

mRNA Expression by UniProt/SwissProt for THADA Gene

Q6YHU6-THADA_HUMAN
Tissue specificity: Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.
genes like me logo Genes that share expressions with THADA: view

Orthologs for THADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THADA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THADA 36
  • 99.51 (n)
  • 99.18 (a)
THADA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THADA 36
  • 87.37 (n)
  • 84.37 (a)
THADA 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THADA 36
  • 87.45 (n)
  • 84.08 (a)
THADA 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thada 36
  • 81.85 (n)
  • 79.13 (a)
Thada 16
Thada 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THADA 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Thada 36
  • 83.03 (n)
  • 79.95 (a)
chicken
(Gallus gallus)
Aves THADA 36
  • 65.23 (n)
  • 59.65 (a)
THADA 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THADA 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thada 36
  • 60.73 (n)
  • 56.07 (a)
zebrafish
(Danio rerio)
Actinopterygii thada 37
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15618 37
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y92H12A.5 37
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for THADA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THADA Gene

ENSEMBL:
Gene Tree for THADA (if available)
TreeFam:
Gene Tree for THADA (if available)

Paralogs for THADA Gene

genes like me logo Genes that share paralogs with THADA: view

No data available for Paralogs for THADA Gene

Variants for THADA Gene

Sequence variations from dbSNP and Humsavar for THADA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1322 -- 43,294,028(-) GACCA(C/T)GTCAA intron-variant
rs2134 -- 43,430,810(+) cagca(A/G)cacaa intron-variant
rs15397 -- 43,230,932(+) TCCCA(A/G)TCCCC utr-variant-3-prime, nc-transcript-variant
rs871852 -- 43,447,215(-) TAGGA(C/G)GGAAC intron-variant
rs881476 -- 43,564,627(+) TCTAA(A/G)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THADA Gene

Variant ID Type Subtype PubMed ID
esv2719991 CNV Deletion 23290073
nsv457163 CNV Loss 19166990
nsv525157 CNV Loss 19592680
esv2663547 CNV Deletion 23128226
esv23574 CNV Loss 19812545
esv2662742 CNV Deletion 23128226
esv8546 CNV Gain 19470904
esv2719992 CNV Deletion 23290073
nsv873973 CNV Loss 21882294
esv272451 CNV Insertion 20981092
nsv520247 CNV Loss 19592680
esv267495 CNV Insertion 20981092
esv2660992 CNV Deletion 23128226
nsv511782 CNV Loss 21212237
esv2719993 CNV Deletion 23290073
esv2678286 CNV Deletion 23128226
nsv873974 CNV Loss 21882294
esv1449377 CNV Insertion 17803354
esv34086 CNV Loss 18971310
dgv4108n71 CNV Loss 21882294
nsv2707 CNV Insertion 18451855
nsv2708 CNV Loss 18451855
esv2658999 CNV Deletion 23128226
dgv148e55 CNV Loss 17911159
nsv873977 CNV Loss 21882294
esv34046 CNV Loss 18971310

Relevant External Links for THADA Gene

HapMap Linkage Disequilibrium report
THADA
Human Gene Mutation Database (HGMD)
THADA

Disorders for THADA Gene

UniProtKB/Swiss-Prot

THADA_HUMAN
  • Note=Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.

(2) MalaCards Diseases for THADA Gene

Search for THADA Gene in MalaCards »

Relevant External Links for THADA

Genetic Association Database (GAD)
THADA
Human Genome Epidemiology (HuGE) Navigator
THADA
genes like me logo Genes that share disorders with THADA: view

Publications for THADA Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. (PMID: 12955091) Rippe V. … Bullerdiek J. (Oncogene 2003) 3 4 23
  3. A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (PMID: 17889454) Drieschner N. … Nimzyk R. (Gene 2007) 4 23
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A. … Parkes M. (Nat. Genet. 2010) 3 49
  5. Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb. (PMID: 12063398) Bol S. … Bullerdiek J. (Cytogenet. Cell Genet. 2001) 2 3

Products for THADA Gene

Sources for THADA Gene

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