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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THADA Gene

protein-coding   GIFtS: 51
GCID: GC02M043393

thyroid adenoma associated

 Explore 11 diseases affiliated with
THADA via our new
 Human Malady Compendium 
Biological research products
for THADA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thyroid Adenoma Associated1 2     FLJ218771
GITA1 2 3     Death Receptor-Interacting Protein2
KIAA17671 3 5     Thyroid Adenoma-Associated Protein2
Gene Inducing Thyroid Adenomas Protein2 3     

External Ids:    HGNC: 192171   Entrez Gene: 638922   Ensembl: ENSG000001159707   OMIM: 6118005   UniProtKB: Q6YHU63   

Export aliases for THADA gene to outside databases

Previous GC identifers: GC02M043432 GC02M043369 GC02M043311 GC02M043193


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THADA gene promoter:
         Nkx2-5   Tal-1beta   ITF-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHADA promoter sequence
   Search SABiosciences Chromatin IP Primers for THADA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THADA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

THADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THADA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M043393:  view genomic region     (about GC identifiers)

Start:
43,393,800 bp from pter      End:
43,823,185 bp from pter
Size:
429,386 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6 (See protein sequence)
Recommended Name: Thyroid adenoma-associated protein  
Size: 1953 amino acids; 219607 Da
Sequence caution: Sequence=BAB15133.1; Type=Erroneous initiation; Sequence=BAB15162.1; Type=Erroneous initiation;
Sequence=BAB21858.2; Type=Erroneous initiation;
Secondary accessions: A8K1V8 B7WNS6 Q3KR04 Q53RC6 Q53TB2 Q6YHU2 Q6ZU38 Q8TAU8 Q96I88 Q9BZF7 Q9C096
Q9H6U0 Q9H6W7
Alternative splicing: 5 isoforms:  Q6YHU6-1   Q6YHU6-2   Q6YHU6-3   Q6YHU6-4   Q6YHU6-5   

Explore the universe of human proteins at neXtProt for THADA: NX_Q6YHU6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6YHU6

  • THADA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001077422.1  NP_001258572.1  NP_001258573.1  NP_071348.3  

    ENSEMBL proteins: 
     ENSP00000386088   ENSP00000386112   ENSP00000385995   ENSP00000381647   ENSP00000384172  
     ENSP00000385003   ENSP00000385441   ENSP00000384266   ENSP00000445294   ENSP00000385469  
     ENSP00000331105   ENSP00000416048  

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    Uscn Proteins for THADA


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    THADA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019442 DUF2428_death-receptor-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6YHU6

    ProtoNet protein and cluster: Q6YHU6

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
    Similarity: Belongs to the THADA family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THADA

    1 GenomeRNAi human phenotype for THADA:
     Increased TP53 protein express 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THADA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for THADA (Q6YHU63 ENSP000003859954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAA1Q131313I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THADA
    Search CenterWatch for drugs/clinical trials and news about THADA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THADA gene (4 alternative transcripts): 
    NM_001083953.1  NM_001271643.1  NM_001271644.1  NM_022065.4  

    Unigene Cluster for THADA:

    Thyroid adenoma associated
    Hs.369592  [show with all ESTs]
    Unigene Representative Sequence: BX641038
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000405975(uc010far.3 uc010fas.1 uc002rsx.4 uc002rsy.4 uc002rta.2)
    ENST00000407351 ENST00000405006(uc002rsw.4 uc002rtb.1) ENST00000398653
    ENST00000467668 ENST00000485018 ENST00000486735 ENST00000473004 ENST00000408045(uc010fat.1 uc002rsz.3)
    ENST00000497770 ENST00000402796 ENST00000485353 ENST00000469323 ENST00000436947
    ENST00000462185 ENST00000402360 ENST00000404790(uc002rtc.4) ENST00000474159


    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THADA
    OriGene shRNA RFP: THADA
    OriGene siRNA: THADA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THADA
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THADA

    Additional cDNA sequence: 

    AB051554.2 AF323176.1 AK025445.1 AK025530.1 AK126004.1 AK126824.1 AK290023.1 AK307915.1 
    AL832141.1 AY149629.1 BC007743.1 BC025773.1 BC037847.1 BC037990.2 BC105976.1 BX641038.1 
    BX648155.1 NR_073394.1 

    22 DOTS entries:

    DT.97840593  DT.312798  DT.101982081  DT.99927036  DT.101975394  DT.95374335  DT.101969018  DT.97798476 
    DT.91920751  DT.97771230  DT.120987317  DT.120987385  DT.120987393  DT.100647752  DT.100728845  DT.101982083 
    DT.65284647  DT.75131153  DT.97836994  DT.101985249  DT.40127345  DT.95149781 

    24/152 AceView cDNA sequences (see all 152):

    BM675242 BQ576266 NM_198554 NM_022065 BC037990 BM717060 BE645712 BE465537 
    BC007743 CA435816 AI569246 AL043113 AI610364 CB241558 AI494424 BM723522 
    CA312282 AI338592 BQ900649 AW250225 AI144206 BF436747 AF323176 AY149633 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THADA (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                    -                                                                                                                 -           -         
    SP2:                                                                                                                                      -           -         
    SP3:                    -                                                     -                                                           -           -         
    SP4:                    -                                                     -                                                           -           -         
    SP5:                    -                                                     -                                                           -           -         

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
    SP1:                                            -     -                             -     -                                                         
    SP2:                                            -     -                             -     -                                                         
    SP3:                                      -     -     -     -                       -     -                                                         
    SP4:                                            -     -                                                                                             
    SP5:                                            -     -                                                                                             


    ECgene alternative splicing isoforms for THADA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THADA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAACATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See THADA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THADA

    SOURCE GeneReport for Unigene cluster: Hs.369592

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
    Tissue specificity: Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine
    and stomach

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THADA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THADA gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thada1 , 5 thyroid adenoma associated1, 5 81.85(n)1
    79.13(a)1
      17 (55.02 cM)5
    2401741  NM_183021.31  NP_898842.21 
     841900565 
    chicken
    (Gallus gallus)
    Aves THADA1 thyroid adenoma associated 65.18(n)
    59.65(a)
      421398  NM_001110059.1  NP_001103529.1 
    lizard
    (Anolis carolinensis)
    Reptilia THADA6
    --
    58(a)
    1 ↔ 1
    GL343231.1(1506730-1673029)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005362941 thyroid adenoma-associated protein homolog 52.9(n)
    46.09(a)
      100536294  XM_003199700.1  XP_003199748.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156186
    --
    20(a)
    1 ↔ 1
    X(19753776-19759557)
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12A.56
    Protein Y92H12A.5
    18(a)
    1 ↔ 1
    I(1491342-1514411)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G551606
    uncharacterized protein
    17(a)
    1 ↔ 1
    3(20445412-20452400)
    rice
    (Oryza sativa)
    Liliopsida --
    HEAT repeat family protein, putative, expressed
    16(a)
    1 ↔ 1
    8(4068811-4076666)


    ENSEMBL Gene Tree for THADA (if available)
    TreeFam Gene Tree for THADA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6375 NCBI SNPs in THADA are shown (see all 6375    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403180481,2
    --43457484(+) TCAATA/GGCTCT 3 -- int10--------
    rs1912693681,2
    --43457866(+) GCAACA/GGAGTC 3 -- int10--------
    rs1426842721,2
    --43457877(+) GCCTCA/GCTTCC 3 -- int10--------
    rs1817961461,2
    --43457971(+) TCACAG/TAAGTA 3 -- int10--------
    rs153971,2
    C,F,H,--43458071(+) TCCCAA/GTCCCC 3 -- nc-transcript-variantut3111Minor allele frequency- G:0.02MN NS EA NA EU 1779
    rs1140159851,2
    C,--43458097(+) ATGCCG/CCTTCT 5 /A /G nc-transcript-variantmis11Minor allele frequency- C:0.01WA 118
    rs1999964141,2
    C,--43458236(+) AATGCA/GTAGTC 5 R C nc-transcript-variantmis10--------
    rs1859937321,2
    --43458343(+) GGTGAC/GAGAGC 5 S C nc-transcript-variantmis10--------
    rs1911493961,2
    C,--43458358(+) CAGGGC/TTTGGG 5 N S nc-transcript-variantmis10--------
    rs1146517031,2
    --43458425(+) AAAGAT/CCAGGG 5 /I /V nc-transcript-variantmis11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for THADA (43393800 - 43643800 bp, first 250kb of THADA)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for THADA
         4 CNVs: 67615 48028 48025 8942
         1 Indel: 60298
    Human Gene Mutation Database (HGMD): THADA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THADA
    DNA2.0 Custom Variant and Variant Library Synthesis for THADA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    THADA for disorders           About GeneDecksing

    OMIM gene information: 611800    OMIM disorders: --

    UniProtKB/Swiss-Prot: THADA_HUMAN, Q6YHU6
  • Note=Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation
  • t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear
    to include a coding region and the fusion events probably result in truncated THADA proteins

    11 diseases for THADA:    About MalaCards
    thyroid adenoma    adenoma    thyroiditis    polycystic ovary syndrome
    cleft lip    cleft palate    diabetes mellitus    crohn's disease
    prostate cancer    obesity    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: THADA (44 documents)

    Export disorders for THADA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THADA gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with THADA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. (PubMed id 12955091)1, 2, 9 Rippe V.... Bullerdiek J. (2003)
    3. Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb. (PubMed id 12063398)1, 3 Bol S....Bullerdiek J. (2001)
    4. A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (PubMed id 17889454)2, 9 Drieschner N....Nimzyk R. (2007)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Replication of association of DENND1A and THADA varian ts with polycystic ovary syndrome in European cohorts. (PubMed id 22180642)1 Goodarzi M.O....Urbanek M. (2012)
    7. Genome-wide association study identifies eight new ris k loci for polycystic ovary syndrome. (PubMed id 22885925)1 Shi Y....Chen Z.J. (2012)
    8. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. (PubMed id 23028138)1 Nitert M.D....Ling C. (2012)
    9. Genome-wide meta-analyses of nonsyndromic cleft lip wi th or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....Nothen M.M. (2012)
    10. Genome-wide meta-analysis identifies novel multiple sc lerosis susceptibility loci. (PubMed id 22190364)1 Patsopoulos N.A....de Bakker P.I. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63892 HGNC: 19217 AceView: THADA Ensembl:ENSG00000115970 euGenes: HUgn63892
    ECgene: THADA H-InvDB: THADA

    (According to HUGE)
    About This Section
    HUGE: KIAA1767

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THADA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THADA gene:
    Search GeneIP for patents involving THADA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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