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Aliases for THADA Gene

Aliases for THADA Gene

  • THADA, Armadillo Repeat Containing 2 3 5
  • Gene Inducing Thyroid Adenomas Protein 3 4
  • GITA 3 4
  • Death Receptor-Interacting Protein 3
  • Thyroid Adenoma-Associated Protein 3
  • Thyroid Adenoma Associated 2
  • KIAA1767 4
  • ARMC13 3

External Ids for THADA Gene

Previous GeneCards Identifiers for THADA Gene

  • GC02M043432
  • GC02M043369
  • GC02M043311
  • GC02M043393

Summaries for THADA Gene

Entrez Gene Summary for THADA Gene

  • This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

GeneCards Summary for THADA Gene

THADA (THADA, Armadillo Repeat Containing) is a Protein Coding gene. Diseases associated with THADA include Adenoma. GO annotations related to this gene include binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THADA Gene

Genomics for THADA Gene

Regulatory Elements for THADA Gene

Enhancers for THADA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F043100 0.7 FANTOM5 ENCODE 5.6 +494.0 493995 3.6 SMARCA4 POLR2A GLIS1 ZFP64 ZBTB33 PRDM10 NR2F2 THADA GC02M043092 RNU6-242P LOC105374570
GH02F043358 0.6 ENCODE 5.1 +237.1 237088 1.4 GATAD2A SOX5 TFE3 FOXA3 ZFP64 TEAD3 RERE SCRT2 ZKSCAN8 CEBPA RNU6-958P THADA ENSG00000234936
GH02F043423 1.4 FANTOM5 Ensembl ENCODE 5.1 +170.7 170738 4.6 PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 FOS THADA ENSG00000234936 RNU6-958P RN7SL531P
GH02F042936 1.5 FANTOM5 Ensembl ENCODE 5.1 +659.4 659390 2.4 PKNOX1 SIN3A DMAP1 ZNF121 SP5 ZHX2 PPARG NFIL3 RCOR2 HMBOX1 THADA GC02M042943 LOC105374568
GH02F043454 1.1 Ensembl ENCODE 5 +136.9 136874 9.3 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 FOS SP5 JUNB MXD4 ENSG00000234936 ZFP36L2 RNU6-958P DYNC2LI1 PLEKHH2 THADA RN7SL531P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THADA on UCSC Golden Path with GeneCards custom track

Promoters for THADA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000300833 156 2201 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for THADA Gene

Chromosome:
2
Start:
43,230,836 bp from pter
End:
43,596,056 bp from pter
Size:
365,221 bases
Orientation:
Minus strand

Genomic View for THADA Gene

Genes around THADA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THADA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THADA Gene

Proteins for THADA Gene

  • Protein details for THADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YHU6-THADA_HUMAN
    Recommended name:
    Thyroid adenoma-associated protein
    Protein Accession:
    Q6YHU6
    Secondary Accessions:
    • A8K1V8
    • B7WNS6
    • Q3KR04
    • Q53RC6
    • Q53TB2
    • Q6YHU2
    • Q6ZU38
    • Q8IY32
    • Q8TAU8
    • Q96I88
    • Q9BZF7
    • Q9C096
    • Q9H6U0
    • Q9H6W7

    Protein attributes for THADA Gene

    Size:
    1953 amino acids
    Molecular mass:
    219607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15133.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15162.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for THADA Gene

neXtProt entry for THADA Gene

Post-translational modifications for THADA Gene

  • Ubiquitination at Lys 702 and Lys 1008
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for THADA Gene

Domains & Families for THADA Gene

Gene Families for THADA Gene

Protein Domains for THADA Gene

Suggested Antigen Peptide Sequences for THADA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6YHU6

UniProtKB/Swiss-Prot:

THADA_HUMAN :
  • Belongs to the THADA family.
Family:
  • Belongs to the THADA family.
genes like me logo Genes that share domains with THADA: view

Function for THADA Gene

Gene Ontology (GO) - Molecular Function for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THADA: view
genes like me logo Genes that share phenotypes with THADA: view

Animal Model Products

miRNA for THADA Gene

miRTarBase miRNAs that target THADA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THADA Gene

Localization for THADA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THADA Gene COMPARTMENTS Subcellular localization image for THADA gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for THADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with THADA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THADA Gene

Pathways & Interactions for THADA Gene

SuperPathways for THADA Gene

No Data Available

Gene Ontology (GO) - Biological Process for THADA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THADA Gene

Transcripts for THADA Gene

Unigene Clusters for THADA Gene

Thyroid adenoma associated:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THADA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9:
SP10: - -

Relevant External Links for THADA Gene

GeneLoc Exon Structure for
THADA
ECgene alternative splicing isoforms for
THADA

Expression for THADA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THADA Gene

Protein differential expression in normal tissues from HIPED for THADA Gene

This gene is overexpressed in Bone (34.4) and Esophagus (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THADA Gene



Protein tissue co-expression partners for THADA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THADA Gene:

THADA

SOURCE GeneReport for Unigene cluster for THADA Gene:

Hs.369592

mRNA Expression by UniProt/SwissProt for THADA Gene:

Q6YHU6-THADA_HUMAN
Tissue specificity: Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.
genes like me logo Genes that share expression patterns with THADA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THADA Gene

Orthologs for THADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THADA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THADA 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia THADA 34 35
  • 87.45 (n)
cow
(Bos Taurus)
Mammalia THADA 34 35
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Thada 34
  • 83.03 (n)
mouse
(Mus musculus)
Mammalia Thada 34 16 35
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia THADA 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves THADA 34 35
  • 65.23 (n)
lizard
(Anolis carolinensis)
Reptilia THADA 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thada 34
  • 60.73 (n)
zebrafish
(Danio rerio)
Actinopterygii thada 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15618 35
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y92H12A.5 35
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for THADA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THADA Gene

ENSEMBL:
Gene Tree for THADA (if available)
TreeFam:
Gene Tree for THADA (if available)

Paralogs for THADA Gene

No data available for Paralogs for THADA Gene

Variants for THADA Gene

Sequence variations from dbSNP and Humsavar for THADA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs201555818 Benign 43,556,551(+) TCCCC(A/G)AATCC intron-variant, nc-transcript-variant, reference, missense
rs769958179 Benign 43,586,943(+) GAAGA(C/T)GAGAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10164789 -- 43,558,663(+) GCTTT(A/G)GCTTC intron-variant
rs10165527 -- 43,555,729(+) CCATC(C/T)TGGAA intron-variant, downstream-variant-500B
rs10166054 -- 43,391,901(+) AAGTC(C/T)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THADA Gene

Variant ID Type Subtype PubMed ID
dgv148e55 CNV loss 17911159
dgv3797n100 CNV loss 25217958
dgv6829n54 CNV loss 21841781
dgv6830n54 CNV loss 21841781
esv1449377 CNV insertion 17803354
esv23574 CNV loss 19812545
esv2658999 CNV deletion 23128226
esv2660992 CNV deletion 23128226
esv2662742 CNV deletion 23128226
esv2663547 CNV deletion 23128226
esv2678286 CNV deletion 23128226
esv2719991 CNV deletion 23290073
esv2719992 CNV deletion 23290073
esv2719993 CNV deletion 23290073
esv2763651 CNV loss 21179565
esv3303215 CNV mobile element insertion 20981092
esv3383365 CNV insertion 20981092
esv34046 CNV loss 18971310
esv34086 CNV loss 18971310
esv3439008 CNV insertion 20981092
esv3555733 CNV deletion 23714750
esv3555744 CNV deletion 23714750
esv3555755 CNV deletion 23714750
esv3583764 CNV loss 25503493
esv3583765 CNV loss 25503493
esv3590524 CNV loss 21293372
esv3590525 CNV loss 21293372
esv3590527 CNV loss 21293372
esv3590529 CNV gain 21293372
esv3590531 CNV loss 21293372
esv3590534 CNV loss 21293372
esv3891993 CNV gain 25118596
esv8546 CNV gain 19470904
nsv1000464 CNV loss 25217958
nsv1001365 CNV gain 25217958
nsv1002186 CNV gain 25217958
nsv1007740 CNV gain 25217958
nsv1015137 CNV loss 25217958
nsv1071590 CNV deletion 25765185
nsv1123322 CNV deletion 24896259
nsv1142255 CNV deletion 24896259
nsv2707 CNV insertion 18451855
nsv2708 CNV deletion 18451855
nsv457163 CNV loss 19166990
nsv511782 CNV loss 21212237
nsv520247 CNV loss 19592680
nsv525157 CNV loss 19592680
nsv581659 CNV loss 21841781
nsv581660 CNV gain 21841781
nsv953774 CNV duplication 24416366

Variation tolerance for THADA Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.23; 96.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THADA Gene

Human Gene Mutation Database (HGMD)
THADA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THADA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THADA Gene

Disorders for THADA Gene

MalaCards: The human disease database

(1) MalaCards diseases for THADA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adenoma
  • acinar cell adenoma
- elite association - COSMIC cancer census association via MalaCards
Search THADA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

THADA_HUMAN
  • Note=Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.

Relevant External Links for THADA

Genetic Association Database (GAD)
THADA
Human Genome Epidemiology (HuGE) Navigator
THADA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THADA
genes like me logo Genes that share disorders with THADA: view

No data available for Genatlas for THADA Gene

Publications for THADA Gene

  1. Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas. (PMID: 12955091) Rippe V. … Bullerdiek J. (Oncogene 2003) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
  4. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PMID: 20878950) Sun J. … Xu J. (Prostate 2011) 3 46 64
  5. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PMID: 21151128) Chen Z.J. … Zhao Y. (Nat. Genet. 2011) 3 46 64

Products for THADA Gene

Sources for THADA Gene

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