Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TH Gene

protein-coding GIFtS: 72
GCID: GC11M002185

tyrosine hydroxylase

Explore 164 diseases affiliated with
TH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tyrosine Hydroxylase¹ ²		DYT14²
TYH² ³ ⁵		Dystonia 14²
DYT5b¹ ²		Tyrosine 3-Monooxygenase²
Tyrosine 3-Hydroxylase² ³		EC 1.14.16⁸
EC 1.14.16.2³ ⁸

External Ids:	HGNC: 11782¹	Entrez Gene: 7054²	Ensembl: ENSG00000180176⁷	OMIM: 191290⁵	UniProtKB: P07101³

Export aliases for TH gene to outside databases

Previous GC identifers: GC11U990132 GC11M002273 GC11M002144 GC11M002149 GC11M002141 GC11M001982

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TH:

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme

in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this

gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding

different isoforms have been noted for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Function: Plays an important role in the physiology of adrenergic neurons

Gene Wiki entry for TH (Tyrosine hydroxylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TH gene promoter:
GR CREB deltaCREB GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TH promoter sequence

Search SABiosciences Chromatin IP Primers for TH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

TH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TH gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M002185: view genomic region (about GC identifiers)

Start:	2,185,159 bp from pter	End:	2,193,107 bp from pter
Size:	7,949 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101 (See protein sequence)

Recommended Name: Tyrosine 3-monooxygenase

Size: 528 amino acids; 58600 Da

Cofactor: Fe(2+) ion

1 PDB 3D structure from and Proteopedia for TH:

2XSN (3D)

Secondary accessions: B7ZL70 Q15585 Q15588 Q15589

Alternative splicing: 4 isoforms: P07101-1 P07101-2 P07101-3 P07101-4

Explore the universe of human proteins at neXtProt for TH: NX_P07101

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07101

4/19 DME Specific Peptides for TH (P07101) (see all 19)

EFGLCKQ

IGLASLG

PQLEDVS

SLGASDE

TH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000351.2 NP_954986.2 NP_954987.2

ENSEMBL proteins:

ENSP00000370571 ENSP00000370567 ENSP00000325951 ENSP00000325831 ENSP00000403440

ENSP00000403546 ENSP00000370560 ENSP00000328814

Reactome Protein details: P07101
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for TH
	OriGene Purified Protein: TH OriGene Protein Over-expression Lysate: TH OriGene Custom Protein Services for TH
	GenScript Custom Purified and Recombinant Proteins Services for TH
	Novus Biologicals TH Protein Novus Biologicals TH Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TH

Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	10907721
GO:0005739	mitochondrion	IEA	--
GO:0005790	smooth endoplasmic reticulum	IDA	12457228
GO:0005829	cytosol	TAS	--

TH for ontologies About GeneDecksing

TH Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TH
	R&D Systems Antibodies for TH (Tyrosine Hydroxylase)
	Cell Signaling Technology (CST) Antibodies for TH (TH iso3, TH)
	OriGene Antibodies (see all 3): TH OriGene Custom Antibody Services for TH
	GenScript Custom Superior Antibodies Services for TH
	Novus Biologicals TH Antibodies
	Abcam antibodies for TH
	Uscn Antibodies for TH
	ThermoFisher Antibodies for TH

Assay Products for TH:

	EMD Millipore Kits and Assays for the Analysis of TH
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TH
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TH for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR019774 Aromatic-AA_hydroxylase_C

IPR021164 Tyrosine_hydroxylase_CS

IPR019773 Tyrosine_3-monooxygenase-like

IPR001273 ArAA_hydroxylase

IPR018301 ArAA_hydroxylase_Fe/CU_BS

Graphical View of Domain Structure for InterPro Entry P07101

ProtoNet protein and cluster: P07101

1 Blocks protein family: IPB001273 Aromatic amino acid hydroxylase

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Function: Plays an important role in the physiology of adrenergic neurons

Catalytic activity: L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin

Enzyme regulation: Phosphorylation leads to an increase in the catalytic activity

Genatlas biochemistry entry for TH:

tyrosine 3-hydroxylase,58.5kDa,mainly expressed in brain and adrenal glands,rate limiting enzyme in the biosynthesis of

catecholamines,potentially associated with longevity in the male,unlikely to be associated with bipolar effective

disorder (MAFD)

Enzyme Numbers (IUBMB): EC 1.14.16.2¹ ² EC 1.14.16²

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TH
		SwitchGear 3'UTR luciferase reporter plasmid: TH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TH (see all 7) OriGene shRNA RFP: TH OriGene siRNA: TH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TH

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TH

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TH (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TH (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for TH
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TH
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TH

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TH
		Search LifeMap BioReagents cell lines for TH

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TH

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0004511	tyrosine 3-monooxygenase activity	IDA	2896667
GO:0005506	iron ion binding	--	--
GO:0005515	protein binding	IPI	11943812
GO:0008198	ferrous iron binding	IEA	--

TH for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TH:

Increased circadian period len

Animal Models:
Mouse knock-outs for TH: Th^tm1Tna Th^tm2Rpa Th^tm1Srt Th^tm1Rpa
15 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Th):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
homeostasis/metabolism	integument	liver/biliary system	mortality/aging	nervous system
no phenotypic analysis	normal	respiratory system	tumorigenesis	vision/eye

TH for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tyrosine metabolism

	Tyrosine metabolism	1.00			Tyrosine metabolism p.1 (dopamine)	0.28
	Tyrosine metabolism p.1 (dopamine)	0.28

Neuroscience

Neuroscience

1.00

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1.00

Nicotine Activity on Dopaminergic Neurons

0.44

Regulation of thyroid hormone activity

Amine-derived hormones

0.21

Biogenic Amine Synthesis

0.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TH

Tyrosine metabolism p.1 (dopamine)

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TH

PKA Signaling

1 Cell Signaling Technology (CST) Pathway for TH

Neuroscience

1 GeneGo (Thomson Reuters) Pathway for TH

Tyrosine metabolism p.1 (dopamine)

5/8 BioSystems Pathways for TH (see all 8)

	Biogenic Amine Synthesis
	Parkinsons Disease Pathway
	SIDS Susceptibility Pathways
	Nicotine Activity on Dopaminergic Neurons
	Monoamine Transport

4 Reactome Pathways for TH

	Catecholamine biosynthesis
	Amine-derived hormones
	Metabolism
	Metabolism of amino acids and derivatives

2 PharmGKB Pathways for TH

	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
	Sympathetic Nerve Pathway (Neuroeffector Junction)

3 Kegg Pathways (Kegg details for TH):

	Tyrosine metabolism
	Metabolic pathways
	Parkinson's disease

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2

TH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for TH (P07101^{2, 3} ENSP00000370571⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-8008185 MINT-8009319 I2D: score=4 STRING: ENSP00000309503
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-8009326 I2D: score=1 STRING: ENSP00000306330
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=3 STRING: ENSP00000215832
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=3 STRING: ENSP00000309591
GCH1	P30793³, ENSP00000378890⁴	I2D: score=2 STRING: ENSP00000378890

About this table

Gene Ontology (GO): 5/70 biological process terms (GO ID links to tree view) (see all 70): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	17520326
GO:0001963	synaptic transmission, dopaminergic	ISS	--
GO:0001975	response to amphetamine	IEA	--
GO:0003007	heart morphogenesis	NAS	12113410
GO:0006585	dopamine biosynthetic process from tyrosine	NAS	10907721

TH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for TH

Browse Tocris compounds for TH

10/11 HMDB Compounds for TH (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
Dihydrobiopterin	(S-(R,S))-2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone (see all 15)	6779-87-9	9753429
Tetrahydrobiopterin	(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol (see all 11)	17528-72-2	12641743
4a-Hydroxytetrahydrobiopterin	2-amino-6-(1,2-dihydroxypropyl)-4a-hydroxy-5,6,7,8-tetrahydropteridin-4(4aH)-one (see all 7)	70110-58-6	--
DL-Dopa	2-Amino-3-(3,4-dihydroxyphenyl)propanoate (see all 19)	63-84-3	--
Iron	Armco iron (see all 19)	7439-89-6	--
L-Dopa	(-)-Dopa (see all 58)	59-92-7	--
L-Phenylalanine	(-)-beta-Phenylalanine (see all 28)	63-91-2	--
L-Tyrosine	(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)	60-18-4	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Sapropterin	(6R)-5,6,7,8-Tetrahydro-L-biopterin (see all 11)	62989-33-7	--

6 DrugBank Compounds for TH About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Phenylalanine	(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)	63-91-2	target	binder	12565907 6621777 1973034 11752352 9642259 16581181
L-Tyrosine	2-Amino-3-(p-hydroxyphenyl)propionic acid (see all 3)	60-18-4	target	binder	17578016 17604359 17561836 11752352 17451064 17520326
Tetrahydrobiopterin	5,6,7,8 Tetrahydrobiopterin (see all 3)	17528-72-2	target	cofactor	11752352 10411647 10643998 10543618 10464780 10197775
Metyrosine	Methyltyrosine (see all 2)	672-87-7	target	binder	17374 7409209 11752352 1168577 15710413
7,8-Dihydrobiopterin	7,8-Dihydro-L-Biopterin (see all 8)	6779-87-9	target	--	17139284 17016423 10592235
Meta-Tyrosine	--	--	target	--	17139284 17016423 10592235

10/127 Novoseek chemical compound relationships for TH gene (see all 127) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	95.8	5025	1967817 (11), 1350320 (9), 15569247 (8), 20430833 (8) (see all 99)
dopamine	90.3	1506	18513370 (6), 9577670 (5), 8917440 (5), 1685006 (4) (see all 99)
catecholamine	87.3	446	8103492 (4), 17698732 (4), 11677263 (3), 19120120 (3) (see all 99)
tyrh(.+)	85.8	7	15468323 (1), 14692751 (1), 20025246 (1), 15287903 (1) (see all 7)
levodopa	84.5	331	11483656 (7), 9326301 (5), 7971745 (4), 9626667 (4) (see all 99)
tetrahydrobiopterin	83.1	107	14500751 (4), 8822146 (3), 9692753 (2), 10938545 (2) (see all 63)
tcat	82	15	11475015 (1), 12428766 (1), 7551967 (1), 18096443 (1) (see all 8)
tetrahydropterin	80.8	4	1675871 (1), 19281164 (1), 8917440 (1), 16618490 (1)
l-amino acid	80.3	91	9924972 (3), 9148252 (2), 10366680 (2), 11263376 (2) (see all 49)
6-hydroxydopamine	79.9	28	11036157 (2), 9622240 (1), 17437548 (1), 12433403 (1) (see all 18)

Search CenterWatch for drugs/clinical trials and news about TH / TY3H

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TH gene (3 alternative transcripts):

NM_000360.3 NM_199292.2 NM_199293.2

Unigene Cluster for TH:

Tyrosine hydroxylase

Hs.435609 [show with all ESTs]

Unigene Representative Sequence: M17589

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381178(uc001lvq.3 uc010qxj.2 uc001lvt.3) ENST00000381175(uc001lvp.3)

ENST00000352909(uc001lvr.3 uc001lvs.3) ENST00000324155(uc009ydh.1)

ENST00000479437 ENST00000416223 ENST00000412076 ENST00000461172 ENST00000381168

ENST00000469226 ENST00000333684

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TH
		SwitchGear 3'UTR luciferase reporter plasmid: TH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TH (see all 7) OriGene shRNA RFP: TH OriGene siRNA: TH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TH

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TH (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TH (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for TH
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TH
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TH

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TH Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TH
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TH
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TH

Additional cDNA sequence:

AY144494.1 AY144495.1 BC104967.1 BC143611.1 BC143614.1 DQ677336.1 DQ677337.1 M17589.1

M20912.1 M24790.1 X05290.1 Y00414.1

8 DOTS entries:

DT.108479 DT.100751588 DT.100022747 DT.91740988 DT.120712419 DT.95159269 DT.102843985 DT.95237873

6 AceView cDNA sequences:

M24790 BQ718391 T27948 NM_000360 NM_199293 NM_199292

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TH (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:			-								-
SP2:											-
SP3:			-		-						-
SP4:			-		-		-				-
SP5:																					-

ECgene alternative splicing isoforms for TH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCCCTGC

About this image

TH expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Substantia Nigra pars Compacta

Adult Dopaminergic Neurons

Selective marker (cell-identifying gene)

Dopaminergic neurons

Brain

Substantia Nigra pars Compacta

Embryonic Dopaminergic Neurons

Dopaminergic neurons

Brain

Ventral Tegmental Area

Adult Dopaminergic Neurons

Dopaminergic neurons

Brain

Ventral Tegmental Area

Embryonic Dopaminergic Neurons

Dopaminergic neurons

Eye

Ganglion Cell Layer

Dopaminergic Amacrine Cells

Amacrine, Retina

Eye

Inner Nuclear Layer

Dopaminergic Amacrine Cells

Amacrine, Retina

Eye

Ganglion Cell Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Midbrain dopaminergic-like neurons (Derivation of functi...)

Ventral midbrain dopaminergic-like neurons (Differentiation of h...)

Ventral/hypothalamic-like neurons (Generation of midbra...)

See TH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TH

SOURCE GeneReport for Unigene cluster: Hs.435609

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Tissue specificity: Mainly expressed in the brain and adrenal glands

SABiosciences Expression via Pathway-Focused PCR Arrays including TH:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Parkinson's Disease in human mouse rat

Neurogenesis in human mouse rat

Terminal Differentiation Markers in human mouse rat

Amino Acid Metabolism II in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TH Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TH
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TH
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TH

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TH gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TH¹	tyrosine hydroxylase	75.1(n) 77.76(a)		395592 NM_204805.1 NP_990136.1
lizard (Anolis carolinensis)	Reptilia	TH⁶	--	70(a)	1 ↔ 1	1(69910150-69935328)
zebrafish (Danio rerio)	Actinopterygii	th¹	tyrosine hydroxylase	67.14(n) 70.08(a)		30384 NM_131149.1 NP_571224.1
fruit fly (Drosophila melanogaster)	Insecta	ple^{1 , 3}	catecholamine metabolism tyrosine 3-monooxygenase³ pale¹	54(a)³ 60.39(n)¹ 51.86(a)¹		3 65C3³ 38746¹ NM_057549.2¹ NP_476897.1¹
worm (Caenorhabditis elegans)	Secernentea	cat-2^{1 , 3}	Expression: dopaminergic neurons, neurons³ Protein CAT-2¹	53(a)³ 54.37(n)¹ 54.27(a)¹		II(257818-260965)³ 173411¹ NM_182103.2¹ NP_871903.2¹

ENSEMBL Gene Tree for TH (if available)
TreeFam Gene Tree for TH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TH gene

PAH² TPH2² TPH1²

3 SIMAP similar genes for TH using alignment to 15 protein entries: TY3H_HUMAN (see all proteins):

TPH1 TPH2 PAH

TH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6356^1,2	C,F,H,	non-pathogenic	6040147(-)	`AGGCCG/ATGCTA`	6	/M /V	mis¹ ese³		25		MN NS EA NA CSA WA EU	8395
rs80338892^1,2	C,	pathogenic	6041963(-)	`CCAGCA/GCAGGA`	6	H R	mis¹		0	--	--	--	--
rs28934581^1,2	C	pathogenic	6042873(-)	`ACGCCA/CCGCAC`	6	T P	mis¹		2		NA	4
rs45471299^1,2	C	pathogenic	6045532(-)	`GTACAC/TGCTGG`	6	T M	mis¹		1		NA	2
rs111911270^1,2		--	1975059(+)	`CCTGCC/AGGCCC`	3	--	ds500¹		1		CSA	1
rs3842726^1,2	C,	--	1975392(-)	`ACAGAG/CACAGA`	3	--	ds500¹		10		EU CA EA WA CSA NS NA	879
rs3842725^1,2	C,	--	1975451(-)	`TCACCG/ATCACA`	3	--	ut3¹ ese³		8		EU CA EA WA CSA NS NA	760
rs78779683^1,2	C,	--	1975793(+)	`GGAGCG/ACCGCA`	6	/R /C	mis¹		1		WA	118
rs3842723^1,2	C,	--	1975982(-)	`GCCACT/CGTGAA`	3	--	int¹		7		EU CA EA WA CSA NS	758
rs116831738^1,2	C,F,	--	1976935(+)	`CCTGAC/TGCTGG`	3	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TH (2185159 - 2193107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TH: --
Human Gene Mutation Database (HGMD): TH

Locus Specific Mutation Databases (LSDB): TH

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TH

DNA2.0 Custom Variant and Variant Library Synthesis for TH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TH for disorders           About GeneDecksing

OMIM gene information: 191290
OMIM disorders: 605407
UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Defects in TH are the cause of Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]. A form of

DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained

involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in

infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to

L-DOPA

Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation

analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls

20/164 diseases for TH (see all 164): About MalaCards

segawa syndrome gtp cyclohydrolase i deficiency chediak-higashi syndrome dopa-responsive dystonia

beckwith-wiedemann syndrome sudden infant death syndrome manic-depressive illness segawa syndrome, recessive

dihydropteridine reductase deficiency central hypoventilation syndrome tyrosine hydroxylase deficiency segawa syndrome, autosomal recessive

stiff-person syndrome alcohol withdrawal delirium supratentorial primitive neuroectodermal tumor chiari malformation

supranuclear palsy guillain-barre syndrome attention deficit hyperactivity disorder primitive neuroectodermal tumor

2 diseases from the University of Copenhagen DISEASES database for TH:

Parkinson's disease Toxic encephalopathy

10/92 Novoseek disease relationships for TH gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	87.1	130	7893377 (4), 10518586 (3), 8822146 (2), 1349211 (2) (see all 81)
dystonia, dopa-responsive, autosomal recessive	76	1	15476168 (1)
gtp cyclohydrolase i deficiency	72.7	4	12891655 (3), 10079965 (1)
parkinsonism	70.2	17	11134401 (1), 18419768 (1), 1356749 (1), 10023444 (1) (see all 14)
pheochromocytoma	63	73	1678741 (4), 1353277 (4), 12651811 (3), 7602797 (3) (see all 36)
neurodegenerative diseases	57.5	3	9228951 (1), 15933869 (1)
lewy body disease	55.7	8	18386627 (2), 17493034 (1), 15933869 (1), 17985144 (1)
neurodegeneration	54.2	12	16543240 (1), 17442064 (1), 1975089 (1), 15681811 (1) (see all 8)
schizophrenia	45.6	57	7893377 (3), 9613851 (3), 20067853 (3), 9686421 (2) (see all 28)
multiple system atrophy	45.6	4	15933869 (1), 10690993 (1)

GeneTests: TH

Tyrosine Hydroxylase Deficiency

Genetic Association Database (GAD): TH
Human Genome Epidemiology (HuGE) Navigator: TH (750 documents)

Export disorders for TH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TH gene, integrated from 9 sources (see all 1603):
(articles sorted by number of sources associating them with TH)

Utopia: connect your pdf to the dynamic
world of online information

Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease. (PubMed id 9613851)^{1, 2, 4, 9} Kunugi H.... Nanko S. (1998)
Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes. (PubMed id 16360899)^{1, 4, 9} Tochigi M....Sasaki T. (2006)
Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. (PubMed id 15077008)^{1, 4, 9} Anney R.J....Williamson R. (2004)
Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism. (PubMed id 9754624)^{1, 2, 9} Ishiguro H.... Shibuya H. (1998)
A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. (PubMed id 16344718)^{1, 4, 9} Rodriguez S....Day I.N. (2006)
TH01, a tetrameric short tandem repeat locus in the tyrosine hydroxylase gene: association with myocardial hypertrophy and death from myocardial infarction? (PubMed id 15735319)^{1, 4, 9} Klintschar M....Kleiber M. (2005)
Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PubMed id 12610512)^{1, 4, 9} Ho G.Y....Chua S.C. (2003)
VNTR polymorphism of tyrosine hydroxylase gene and schizophrenia in the Korean population. (PubMed id 12759555)^{1, 4, 9} Pae C.U....Paik I.H. (2003)
Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. (PubMed id 8817341)^{1, 2, 9} Luedecke B.... Flatmark T. (1996)
Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene. (PubMed id 8528210)^{1, 2, 9} Knappskog P.M.... Bartholome K. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7054	HGNC: 11782	AceView: TH	Ensembl:ENSG00000180176	euGenes: HUgn7054
ECgene: TH	Kegg: 7054	H-InvDB: TH

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TH	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TH
Wikipedia	http://en.wikipedia.org/wiki/Tyrosine_hydroxylase

Intellectual Property for TH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TH gene:
Search GeneIP for patents involving TH

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Kits and Assays for the Analysis of TH
	EMD Millipore Mono- and Polyclonal Antibodies for the study of TH
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TH (Tyrosine Hydroxylase)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TH		OriGene shRNA RFP for TH
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TH		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TH
	OriGene Protein Over-expression Lysate for TH		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TH		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TH		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TH
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TH		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TH		OriGene Custom Protein Services for TH
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TH
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TH
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TH
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TH
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TH
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TH

	GenScript Custom Purified and Recombinant Proteins Services for TH		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TH
	GenScript Custom Assay Services for TH		GenScript Custom Superior Antibodies Services for TH
	GenScript Custom overexpressing Cell Line Services for TH		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for TH
(TH iso3, TH)

	Regulatory tfbs in TH promoter
	Search Chromatin IP Primers for TH
	RT² qPCR Primer Assay in human, mouse, rat TH
	GNC Network for TH
	SABiosciences PCR Arrays including human, mouse, rat TH

Search Tocris compounds for TH

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs/Proteins for TH
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TH antibodies
	TH proteins
	TH lysates

	Antibodies for TH
	See all of Abcam's Antibodies, Kits and Proteins for TH
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TH Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TH

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TH

	SwitchGear 3'UTR luciferase reporter plasmids for TH
	SwitchGear Promoter luciferase reporter plasmids for TH

ThermoFisher Antibodies for TH

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TH

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TH gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TH Gene

tyrosine hydroxylase

Aliases
for TH gene

Summaries
for TH gene

Genomic Views
for TH gene

Proteins
for TH gene

Protein Domains /
Families
for TH gene

Function
for TH gene

Pathways & Interactions
for TH gene

Drugs & Compounds
for TH gene

Transcripts
for TH gene

Expression
for TH gene

Orthologs
for TH gene

Paralogs
for TH gene

Genomic Variants
for TH gene

Disorders / Diseases
for TH gene

Publications
for TH gene

External Searches for TH gene

Genome Databases showing TH gene

Other Databases showing TH gene

Specialized Databases showing TH gene

Intellectual Property
for TH gene

Products
for TH gene

View Random Gene

Beckwith-Wiedemann Syndrome
Supranuclear Palsy Progressive
DYSTONIA, DOPA-RESPONSIVE, AUTOSOMAL RECESSIVE
Dementia
Hyperphenylalaninemia
Phenylketonurias
essential hypertension
Herpes Simplex
Spastic Paraplegia
Teratocarcinoma
Ischemia
Intoxication
Breast Cancer
Schizophrenia
Ganglioneuroblastoma
Placental Insufficiency
ENCEPHALOPATHY
Cancer
Mood Disorders
Lymphoma
chediak-higashi syndrome
Shock
Inflammation
GTP CYCLOHYDROLASE I DEFICIENCY
AFFECTIVE DISORDER MAJOR
immunodeficiency
psychiatric disorder
Bipolar Disorder
Complex partial seizures
Rheumatoid Arthritis
prostate cancer
hypofunction
Mental Retardation
Cardiovascular Diseases
Pheochromocytoma
Metastasis
Depressive disorder
Necrosis
Sarcoma
CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL
AUTISTIC
Preeclampsia
Huntington Disease
Parkinsonism
Senile Plaques
Neurofibrillary Tangles
Rhabdomyosarcoma Alveolar
Neurodegenerative Diseases
Neurological Disorders
Parkinson Disease
Hyperprolactinemia
Multiple Endocrine Neoplasia
Sudden infant death syndrome
Gliosis
INFARCT
Minimal Residual Disease
Addisons Disease
Alzheimers Disease
Osteosarcoma
neurodegeneration
AQUEDUCTAL STENOSIS
Multiple System Atrophy
HEPATOCELLULAR CARCINOMA
APECED
Ganglioglioma
Carcinoid
Effects Cardiovascular
Amyotrophic Lateral Sclerosis
Encephalopathies Hypoxic-Ischemic
Paraganglioma
HEART FAILURE
Wilms tumor
Hearing Loss Noise-Induced
Insulin Resistance
Ganglioneuroma
Bleeding
Hyperaldosteronism
Ewings sarcoma
Movement Disorders
STROKE
neuron loss
neuroblastoma metastatic
Lewy Body Disease
Brain Diseases
liver metastases
Rett Syndrome
Cholera
NIDDM
Tyrosine Hydroxylase Deficiency
Adjustment Disorders
Neuropathology
Psychotic
Lupus Erythematosus Systemic

Advanced Search

Export list of displayed genes

TH Gene

tyrosine hydroxylase

Aliasesfor TH gene

Summariesfor TH gene

Genomic Viewsfor TH gene

Proteinsfor TH gene

Protein Domains /Familiesfor TH gene

Functionfor TH gene

Pathways & Interactionsfor TH gene

Drugs & Compoundsfor TH gene

Transcriptsfor TH gene

Expression for TH gene

Orthologsfor TH gene

Paralogsfor TH gene

Genomic Variantsfor TH gene

Disorders / Diseasesfor TH gene

Publicationsfor TH gene

External Searches for TH gene

Genome Databases showing TH gene

Other Databases showing TH gene

Specialized Databases showing TH gene

Intellectual Propertyfor TH gene

Productsfor TH gene

View Random Gene

Aliases
for TH gene

Summaries
for TH gene

Genomic Views
for TH gene

Proteins
for TH gene

Protein Domains /
Families
for TH gene

Function
for TH gene

Pathways & Interactions
for TH gene

Drugs & Compounds
for TH gene

Transcripts
for TH gene

Expression
for TH gene

Orthologs
for TH gene

Paralogs
for TH gene

Genomic Variants
for TH gene

Disorders / Diseases
for TH gene

Publications
for TH gene

Intellectual Property
for TH gene

Products
for TH gene