TGS1 Gene
protein-coding GIFtS: 57
GCID: GC08P056685
|
|
trimethylguanosine synthase 1(Previous names: nuclear receptor coactivator 6 interacting protein, trimethylguanosine...)
(Previous symbol: NCOA6IP)
| |
Aliases
for TGS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trimethylguanosine Synthase 11 2 | | Trimethylguanosine Synthase Homolog (S. Cerevisiae)1 | | NCOA6IP1 2 3 5 | | SEREX-Defined1 | | PIMT1 2 3 5 | | PRIP-Interacting Protein PIPMT2 | | Nuclear Receptor Coactivator 6 Interacting Protein1 2 | | PRIP-Interacting Protein With Methyltransferase Domain2 | | Cap-Specific Guanine-N2 Methyltransferase2 3 | | Trimethylguanosine Synthase2 | | Hepatocellular Carcinoma-Associated Antigen 1372 3 | | Trimethylguanosine Synthase Homolog2 | | Nuclear Receptor Coactivator 6-Interacting Protein2 3 | | EC 2.1.1.-3 | | PIPMT2 3 | | HCA1373 | | CLL-Associated Antigen KW-22 3 | | EC 2.1.18 | | PRIP-Interacting Protein With Methyltransferase Motif2 3 | | |
Export aliases for TGS1 gene to outside databasesPrevious GC identifers: GC08P056849 GC08P052154 |
Summaries
for TGS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TGS1_HUMAN, Q96RS0Function: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps ofsnRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration innuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role intranscriptional regulation
Gene Wiki entry for TGS1
|
Genomic Views
for TGS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGS1 gene promoter:
TBP AML1a POU3F1 PPAR-gamma1 NRF-2 TFIID Cart-1 ZID PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q11 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q11TGS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P056685: view genomic region
(about GC identifiers)
Start:
|
56,685,701 bp from pter |
End:
|
56,738,007 bp from pter |
Size:
|
52,307 bases |
Orientation:
|
plus strand |
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Proteins
for TGS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TGS1_HUMAN, Q96RS0 (See
protein sequence)Recommended Name: Trimethylguanosine synthase Size: 853 amino acids; 96620 Da
Subunit: May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN
Subcellular location: Cytoplasm. Nucleus, Cajal body. Note=A 90 kDa isoform is found in the nucleus while a 55 kDaisoform is found in the cytoplasm and colocalizes with the tubulin network
Sequence caution: Sequence=AAH11999.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB15516.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for TGS1:3EGI (3D)
3GDH (3D)
Secondary accessions: A6NJQ5 Q5GH23 Q8TDG9 Q96QU3 Q9H5V3Explore the universe of human proteins at neXtProt for TGS1: NX_Q96RS0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RS0
2 DME Specific Peptides for TGS1 (Q96RS0)
TGS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079107.6
ENSEMBL proteins: ENSP00000260129 ENSP00000430467 Reactome Protein details: Q96RS0
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TGS1 for ontologies About GeneDecksing
TGS1 Antibody Products:
Assay Products for TGS1: |
Protein
Domains /
Families
for TGS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGS1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96RS0ProtoNet protein and cluster: Q96RS0 1 Blocks protein family: IPB000241 Putative RNA methylase
UniProtKB/Swiss-Prot: TGS1_HUMAN, Q96RS0Similarity: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family |
Function
for TGS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TGS1_HUMAN, Q96RS0Function: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps ofsnRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration innuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role intranscriptional regulationCatalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(2,7)G(5')pppR-RNACatalytic activity: S-adenosyl-L-methionine + m(2,7)G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(2,2,7)G(5')pppR-RNABiophysicochemical properties: Kinetic parameters: KM=30 uM for m(7)GDP; KM=5 uM for S-adenosyl-L-methionine; pHdependence: Optimum pH is 8.5-9.5;Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TGS1 (NM_080591) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGS1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0071164 | RNA trimethylguanosine synthase activity |
IDA | 16687569 |
TGS1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TGS1:
Animal Models:
Mouse knock-out Tgs1tm1.2Jkr for TGS1
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tgs1):
TGS1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TGS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | | | 2 | Metabolism | | | 3 | SLBP independent Processing of Histone Pre-mRNAs | | | 4 | RNA transport | | | 5 | Metabolism of mRNA | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for TGS1 (see all 8)
1 
Kegg Pathway (Kegg details for TGS1):
TGS1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/128 Interacting proteins for TGS1 (Q96RS02, 3 ENSP000002601294) via UniProtKB, MINT, STRING, and/or I2D (see all 128)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
TGS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TGS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGS1
Search CenterWatch for drugs/clinical trials and news about TGS1
|
Transcripts
for TGS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGS1 gene: NM_024831.6 Unigene Cluster for TGS1: Trimethylguanosine synthase 1 Hs.335068 [show with all ESTs]Unigene Representative Sequence: AF2863403 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260129(uc003xsj.4 uc010lyh.3) ENST00000523948 ENST00000519494
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TGS1 (NM_080591) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGS1 |
Additional cDNA sequence: AF147389.1 AF286340.1 AF432215.1 AK026648.1 AK054705.1 AK055178.1 AK314693.1 AL832426.1 AY028423.1 AY534911.1 BC011999.1 BX648548.1 9 DOTS entries: DT.210042 DT.99996602 DT.95363373 DT.92421259 DT.100647450 DT.101971924 DT.91671929 DT.100022368 DT.95103538 24/100 AceView cDNA sequences (see all 100): CR594349 BM670094 BU160185 AV718265 BU632676 AA915951 AW263283 AA234475 AK054705 BU156412 AI379695 AA360838 AF432215 BI335838 BE550365 BC011999 BM971348 AK026648 BE891053 BQ218527 BM699450 AL832426 BX399822 BP343629
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TGS1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TGS1
|
Expression
for TGS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACTGCACT
About this image
See TGS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGS1
SOURCE GeneReport for Unigene cluster: Hs.335068
UniProtKB/Swiss-Prot: TGS1_HUMAN, Q96RS0Tissue specificity: Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including TGS1: | Nuclear Receptors & Coregulators in human mouse rat | | PPAR Targets in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TGS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGS1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGS1 |
Orthologs
for TGS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TGS1 gene from 10/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tgs11 , 5 |
trimethylguanosine synthase homolog (S. cerevisiae)1, 5 |
81.98(n)1
75.06(a)1 |
|
4 (1.99 cM)5
1169401 NM_054089.41 NP_473430.31
35748755 |
chicken
(Gallus gallus) |
Aves |
TGS11 |
trimethylguanosine synthase 1 |
62.33(n)
55.14(a) |
|
421126 NM_001006389.1 NP_001006389.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TGS16 |
-- |
48(a) |
1 ↔ 1 |
GL343244.1(220614-241617) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.330992 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.79(n) |
|
AW642636.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005375521 |
trimethylguanosine synthase-like |
52(n)
42.69(a) |
|
100537552 XM_003197865.1 XP_003197913.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
tatl6 |
tat-like |
34(a) |
1 ↔ 1 |
3R(14081252-14083399) |
worm
(Caenorhabditis elegans) |
Secernentea |
T08G11.46 |
Protein T08G11.4, isoform a |
30(a) |
1 ↔ 1 |
I(8902739-8905527) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TGS1(YPL157W)4
TGS11 |
Trimethyl guanosine synthase, conserved nucleolar methyl more4
Tgs1p1 |
46.86(n)1
38.12(a)1 |
|
16(254814-255761)4
8559461, 4 NP_015168.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G305506AT1G452316 |
S-adenosyl-L-methionine-dependent methyltransferas...S-adenosylmethionine-dependent methyltransferase d... |
31(a)28(a) |
many → 1many → 1 |
1(10819554-10823659) 1(17147837-17151194) |
rice
(Oryza sativa) |
Liliopsida |
---- |
RNA cap guanine-N2 methyltransferase domain contai...RNA cap guanine-N2 methyltransferase domain contai... |
35(a)23(a) |
many → 1many → 1 |
6(4400652-4402236) 3(16037640-16044185) |
ENSEMBL Gene Tree for TGS1 (if available)
TreeFam Gene Tree for TGS1 (if available) |
Paralogs
for TGS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TGS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGS1 (56685701 - 56738007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TGS1
3 CNVs: 53572 5256 52585 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGS1 |
|
Disorders
/ Diseases
for TGS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGS1 for disorders About GeneDecksing
OMIM gene information: 606461
OMIM disorders: --
13  diseases for TGS1: About MalaCardshepatocellular carcinoma spinal muscular atrophy spina bifida muscular atrophy
carcinoma chronic lymphocytic leukemia lymphocytic leukemia homocysteine
leukemia ataxia cholesterol hepatitis
neuronitis
Human Genome Epidemiology (HuGE) Navigator: TGS1 (4 documents)
Export disorders for TGS1 gene to outside databases
|
Publications
for TGS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGS1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TGS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. (PubMed id 19307714)1, 2, 3 Monecke T.... Ficner R. (2009)
- Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. (PubMed id 11517327)1, 2, 3 Zhu Y.-J.... Reddy J.K. (2001)
- Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. (PubMed id 19386620)1, 2 Monecke T.... Ficner R. (2009)
- Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7- trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. (PubMed id 18775984)1, 2 Hausmann S.... Schwer B. (2008)
- Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. (PubMed id 16687569)1, 2 Lemm I.... Luehrmann R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron. (PubMed id 12776181)1, 2 Mouaikel J.... Bordonne R. (2003)
- Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localize to the cytoplasm and nucleus. (PubMed id 12943661)1, 2 Enuenlue I.... Boros I. (2003)
- Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. (PubMed id 12200376)1, 2 Krackhardt A.M.... Gribben J.G. (2002)
|
External Searches for TGS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TGS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TGS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TGS1 gene:
Search GeneIP for patents involving TGS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TGS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TGS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TGS1 | | OriGene 3'-UTR Clone for TGS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TGS1 | | OriGene Custom Protein Services for TGS1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGS1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGS1 |
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| | | | Search Tocris compounds for TGS1 |
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 | | | TGS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGS1 |
|  |  |  | | | | ThermoFisher Antibodies for TGS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGS1 |
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