Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TGS1 Gene

Aliases for TGS1 Gene

  • Trimethylguanosine Synthase 1 2 3
  • PRIP-Interacting Protein With Methyltransferase Motif 3 4
  • Nuclear Receptor Coactivator 6 Interacting Protein 2 3
  • Nuclear Receptor Coactivator 6-Interacting Protein 3 4
  • Hepatocellular Carcinoma-Associated Antigen 137 3 4
  • Cap-Specific Guanine-N2 Methyltransferase 3 4
  • CLL-Associated Antigen KW-2 3 4
  • NCOA6IP 3 4
  • PIPMT 3 4
  • PIMT 3 4
  • PRIP-Interacting Protein With Methyltransferase Domain 3
  • Trimethylguanosine Synthase Homolog (S. Cerevisiae) 2
  • Trimethylguanosine Synthase Homolog 3
  • PRIP-Interacting Protein PIPMT 3
  • SEREX-Defined 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • HCA137 4

External Ids for TGS1 Gene

Previous HGNC Symbols for TGS1 Gene

  • NCOA6IP

Previous GeneCards Identifiers for TGS1 Gene

  • GC08P056849
  • GC08P056685
  • GC08P052154

Summaries for TGS1 Gene

GeneCards Summary for TGS1 Gene

TGS1 (Trimethylguanosine Synthase 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Organelle biogenesis and maintenance. GO annotations related to this gene include methyltransferase activity and RNA trimethylguanosine synthase activity.

UniProtKB/Swiss-Prot for TGS1 Gene

  • Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Gene Wiki entry for TGS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGS1 Gene

Genomics for TGS1 Gene

Regulatory Elements for TGS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TGS1 Gene

Chromosome:
8
Start:
55,773,142 bp from pter
End:
55,825,448 bp from pter
Size:
52,307 bases
Orientation:
Plus strand

Genomic View for TGS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGS1 Gene

Proteins for TGS1 Gene

  • Protein details for TGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RS0-TGS1_HUMAN
    Recommended name:
    Trimethylguanosine synthase
    Protein Accession:
    Q96RS0
    Secondary Accessions:
    • A6NJQ5
    • Q5GH23
    • Q8TDG9
    • Q96QU3
    • Q9H5V3

    Protein attributes for TGS1 Gene

    Size:
    853 amino acids
    Molecular mass:
    96620 Da
    Quaternary structure:
    • May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.
    SequenceCaution:
    • Sequence=AAH11999.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TGS1 Gene

neXtProt entry for TGS1 Gene

Proteomics data for TGS1 Gene at MOPED

Selected DME Specific Peptides for TGS1 Gene

Post-translational modifications for TGS1 Gene

  • Ubiquitination at Lys 44 and Lys 646
  • Modification sites at PhosphoSitePlus

Other Protein References for TGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TGS1 Gene

Protein Domains for TGS1 Gene

Suggested Antigen Peptide Sequences for TGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RS0

UniProtKB/Swiss-Prot:

TGS1_HUMAN :
  • Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
Family:
  • Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.
genes like me logo Genes that share domains with TGS1: view

No data available for Gene Families for TGS1 Gene

Function for TGS1 Gene

Molecular function for TGS1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for m(7)GDP {ECO:0000269 PubMed:18775984}; KM=5 uM for S-adenosyl-L-methionine {ECO:0000269 PubMed:18775984}; pH dependence: Optimum pH is 8.5-9.5. {ECO:0000269 PubMed:18775984};
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + m(7)G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(2,7)G(5)pppR-RNA
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + m(2,7)G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(2,2,7)G(5)pppR-RNA
UniProtKB/Swiss-Prot Function:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Enzyme Numbers (IUBMB) for TGS1 Gene

Gene Ontology (GO) - Molecular Function for TGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21522132
GO:0008168 methyltransferase activity --
GO:0071164 RNA trimethylguanosine synthase activity IDA 16687569
genes like me logo Genes that share ontologies with TGS1: view
genes like me logo Genes that share phenotypes with TGS1: view

Animal Models for TGS1 Gene

MGI Knock Outs for TGS1:

Animal Model Products

miRNA for TGS1 Gene

miRTarBase miRNAs that target TGS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGS1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TGS1 Gene

Localization for TGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGS1 Gene

Cytoplasm. Nucleus, Cajal body. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGS1 Gene COMPARTMENTS Subcellular localization image for TGS1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 12943661
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12943661
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TGS1: view

Pathways & Interactions for TGS1 Gene

genes like me logo Genes that share pathways with TGS1: view

Pathways by source for TGS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nuclear Receptors & Coregulators in human,mouse,rat
    • PPAR Targets in human,mouse,rat

Gene Ontology (GO) - Biological Process for TGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0001510 RNA methylation --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009452 7-methylguanosine RNA capping IEA --
genes like me logo Genes that share ontologies with TGS1: view

No data available for SIGNOR curated interactions for TGS1 Gene

Drugs & Compounds for TGS1 Gene

(2) Drugs for TGS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with TGS1: view

Transcripts for TGS1 Gene

Unigene Clusters for TGS1 Gene

Trimethylguanosine synthase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - - - -
SP3:

Relevant External Links for TGS1 Gene

GeneLoc Exon Structure for
TGS1
ECgene alternative splicing isoforms for
TGS1

Expression for TGS1 Gene

mRNA expression in normal human tissues for TGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TGS1 Gene

This gene is overexpressed in Lung (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGS1 Gene



SOURCE GeneReport for Unigene cluster for TGS1 Gene Hs.335068

mRNA Expression by UniProt/SwissProt for TGS1 Gene

Q96RS0-TGS1_HUMAN
Tissue specificity: Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
genes like me logo Genes that share expression patterns with TGS1: view

Protein tissue co-expression partners for TGS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TGS1 Gene

Orthologs for TGS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TGS1 35
  • 79.13 (n)
  • 74.17 (a)
TGS1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGS1 35
  • 86.66 (n)
  • 82.05 (a)
TGS1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgs1 35
  • 81.98 (n)
  • 75.06 (a)
Tgs1 16
Gm5117 36
  • 69 (a)
OneToMany
Tgs1 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TGS1 35
  • 98.98 (n)
  • 98.12 (a)
TGS1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgs1 35
  • 80.23 (n)
  • 74.11 (a)
oppossum
(Monodelphis domestica)
Mammalia TGS1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGS1 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TGS1 35
  • 62.73 (n)
  • 56.02 (a)
TGS1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGS1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17643 35
tgs1 35
  • 60.23 (n)
  • 50.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33099 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537552 35
  • 53.34 (n)
  • 44.85 (a)
tgs1 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010425 35
  • 47.93 (n)
  • 43.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta tatl 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T08G11.4 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGS1 36
  • 28 (a)
OneToOne
TGS1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6425 36
  • 45 (a)
OneToOne
Species with no ortholog for TGS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TGS1 Gene

ENSEMBL:
Gene Tree for TGS1 (if available)
TreeFam:
Gene Tree for TGS1 (if available)

Paralogs for TGS1 Gene

No data available for Paralogs for TGS1 Gene

Variants for TGS1 Gene

Sequence variations from dbSNP and Humsavar for TGS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs896126 -- 55,789,424(-) ATGAC(C/T)GTAAA intron-variant
rs1376207 -- 55,780,241(-) agtaa(A/G)caatg intron-variant
rs1376208 -- 55,780,175(-) AAAAG(A/C/G)AAAAA intron-variant
rs1868746 -- 55,788,889(-) GAGAC(A/T)GTAAG intron-variant
rs1868747 -- 55,782,149(-) TAAAT(A/T)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGS1 Gene

Variant ID Type Subtype PubMed ID
dgv459n21 CNV Gain 19592680
nsv527341 CNV Gain 19592680
esv2422388 CNV Duplication 17116639
nsv890930 CNV Gain 21882294
nsv510148 CNV Loss 20534489
dgv889n27 CNV Gain 19166990

Variation tolerance for TGS1 Gene

Residual Variation Intolerance Score: 94.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGS1 Gene

HapMap Linkage Disequilibrium report
TGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGS1 Gene

Disorders for TGS1 Gene

Relevant External Links for TGS1

Genetic Association Database (GAD)
TGS1
Human Genome Epidemiology (HuGE) Navigator
TGS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGS1
genes like me logo Genes that share disorders with TGS1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGS1 Gene

Publications for TGS1 Gene

  1. Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. (PMID: 19307714) Monecke T. … Ficner R. (Acta Crystallogr. D 2009) 2 67
  2. DTL, the Drosophila homolog of PIMT/Tgs1 nuclear receptor coactivator-interacting protein/RNA methyltransferase, has an essential role in development. (PMID: 15684427) Komonyi O. … Boros I. (J. Biol. Chem. 2005) 23 67
  3. Intimate relationship between the genes of two transcriptional coactivators, ADA2a and PIMT, of Drosophila. (PMID: 15777699) PA!pai G. … Boros I. (Gene 2005) 23 67
  4. Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. (PMID: 11983179) Mouaikel J. … BordonnAc R. (Mol. Cell 2002) 2 67
  5. Metallothionein expression and tumor growth in the transplantable pregnancy-independent mouse mammary tumor. (PMID: 11459019) Yamamura Y. … Ohta Y. (J. Vet. Med. Sci. 2001) 23 67

Products for TGS1 Gene

Sources for TGS1 Gene

Back to Top

Content