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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGOLN2 Gene

protein-coding   GIFtS: 54
GCID: GC02M085538

trans-golgi network protein 2

 Explore 6 diseases affiliated with
TGOLN2 via our new
 Human Malady Compendium 
Biological research products
for TGOLN2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Trans-Golgi Network Protein 21 2     TTGN21 2
TGN461 2 3 5     Trans-Golgi Network Protein TGN512 3
TGN481 2 3     TGN38 Homolog2 3
TGN511 2 3     Trans-Golgi Network Integral Membrane Protein 22
TGN381 2 5     Trans-Golgi Network Protein (46, 48, 51kD Isoforms)2

External Ids:    HGNC: 154501   Entrez Gene: 106182   Ensembl: ENSG000001522917   OMIM: 6030625   UniProtKB: O434933   

Export aliases for TGOLN2 gene to outside databases

Previous GC identifers: GC02M085444 GC02M085843 GC02M085506 GC02M085523 GC02M085519 GC02M085456 GC02M085398 GC02M085442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGOLN2:
This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting
station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi
network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493
Function: May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Wiki entry for TGOLN2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGOLN2 gene promoter:
         HOXA9   HOXA9B   GATA-3   AP-2alpha isoform 3   AP-2alpha isoform 2   Meis-1a   AP-2alpha isoform 4   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGOLN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGOLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGOLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TGOLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGOLN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M085538:  view genomic region     (about GC identifiers)

Start:
85,545,146 bp from pter      End:
85,555,548 bp from pter
Size:
10,403 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493 (See protein sequence)
Recommended Name: Trans-Golgi network integral membrane protein 2 precursor  
Size: 480 amino acids; 51113 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network
membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi
network and the cell surface returning via endosomes
Secondary accessions: B8ZZ88 O15282 O43492 O43499 O43500 O43501 Q53G68 Q53GV2 Q6MZV1 Q6ZTM7 Q8N6T8
Q92760 Q96QL2
Alternative splicing: 6 isoforms:  O43493-1   O43493-2   O43493-3   O43493-4   O43493-5   O43493-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TGOLN2: NX_O43493

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43493

  • TGOLN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193769.1  NP_001193770.1  NP_001193773.1  NP_006455.2  

    ENSEMBL proteins: 
     ENSP00000366603   ENSP00000381312   ENSP00000386443   ENSP00000387035   ENSP00000391190  
     ENSP00000282120  
    Reactome Protein details: O43493
    Human Recombinant Protein Products: 
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    Uscn Proteins for TGOLN2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IEA--
    GO:0005886plasma membrane IEA--


    TGOLN2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TGOLN2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026084 TGN38

    Graphical View of Domain Structure for InterPro Entry O43493

    ProtoNet protein and cluster: O43493


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493
    Function: May be involved in regulating membrane traffic to and from trans-Golgi network

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    hsa-miR-579 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-624
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147


    TGOLN2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    trans-Golgi Network Vesicle Budding1.00
    Golgi Associated Vesicle Biogenesis0.89
    Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    Membrane Trafficking1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for TGOLN2
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    TGOLN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGOLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for TGOLN2 (O434931, 2, 3 ENSP000003666034) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINP099582, 3, ENSP000002681714MINT-3372400 I2D: score=1 STRING: ENSP00000268171
    MMP14P502812, 3, ENSP000003082084MINT-7897512 I2D: score=1 STRING: ENSP00000308208
    GGA3Q9NZ522, 3, ENSP000002455414MINT-3372421 I2D: score=1 STRING: ENSP00000245541
    IGF2RP117172, 3, ENSP000003494374MINT-3372318 I2D: score=1 STRING: ENSP00000349437
    NCSTNQ925422, 3, ENSP000002947854MINT-6174913 I2D: score=1 STRING: ENSP00000294785
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGOLN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGOLN2
    2 Novoseek chemical compound relationships for TGOLN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 72.1 3 17914056 (2), 19888988 (1)
    tyrosine 5.41 5 10050758 (3), 9422759 (1), 8436587 (1)

    Search CenterWatch for drugs/clinical trials and news about TGOLN2 / TGON2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TGOLN2 gene (4 alternative transcripts): 
    NM_001206840.1  NM_001206841.1  NM_001206844.1  NM_006464.3  

    Unigene Cluster for TGOLN2:

    Trans-golgi network protein 2
    Hs.593382  [show with all ESTs]
    Unigene Representative Sequence: NM_001206840
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377386(uc002spb.3 uc002soz.3 uc021vjw.1 uc021vjx.1 uc002spa.3)
    ENST00000398263 ENST00000409232 ENST00000409015 ENST00000444342(uc002spc.2)
    ENST00000282120

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    hsa-miR-579 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-624
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    Additional cDNA sequence: 

    AF027515.1 AF027516.1 AK025557.1 AK126465.1 AK222829.1 AK223063.1 AK312479.1 AL133437.1 
    BC008461.1 BC028219.1 BC035237.1 BC046196.1 BC062782.1 BX640733.1 BX640818.1 BX640868.1 
    U62390.1 X94333.1 

    24/26 DOTS entries (see all 26):

    DT.97804475  DT.97804688  DT.418916  DT.100761333  DT.114052  DT.120978787  DT.40303831  DT.100825163 
    DT.100825160  DT.100031368  DT.120978857  DT.100825158  DT.91898610  DT.95192821  DT.100800774  DT.100825165 
    DT.120978831  DT.100825166  DT.121636327  DT.100759309  DT.100809648  DT.100825157  DT.120978731  DT.120978856 

    24/596 AceView cDNA sequences (see all 596):

    BQ681523 AI758631 AI560617 T17281 H72326 BM802140 BF724754 AA814306 
    CR601093 AI286223 AI092252 AK126465 CB216875 AW197946 BP347721 BU539767 
    CD108293 AA025201 BU188682 CA426369 AA115120 BX477881 CB110942 CR618666 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TGOLN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                  -               
    SP2:                                                                  
    SP3:                                                  -               
    SP4:                                -                                 
    SP5:                          -     -     -     -     -     -         


    ECgene alternative splicing isoforms for TGOLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGOLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGATAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TGOLN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGOLN2

    SOURCE GeneReport for Unigene cluster: Hs.593382

    UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493
    Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform
    TGN48 is barely expressed in embryonic kidney and promyelocytic cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TGOLN2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TGOLN21 trans-golgi network protein 2 43.2(n)
    31.17(a)
      426548  XM_424186.3  XP_424186.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    34(a)
    33(a)
    1 ↔ many
    1 ↔ many
    GL343238.1(47984-54504)
    GL344758.1(4472-8956)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005375761 uncharacterized LOC100537576 48.82(n)
    34.57(a)
      100537576  XM_003199153.1  XP_003199201.1 


    ENSEMBL Gene Tree for TGOLN2 (if available)
    TreeFam Gene Tree for TGOLN2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 NCBI SNPs in TGOLN2 are shown (see all 260    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739430971,2
    C,--85544644(+) CAGAAC/TATGGA 4 -- ds50012Minor allele frequency- T:0.15WA 120
    rs568701241,2
    C,--85544873(+) TGGGAG/AGCCAA 4 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1928670231,2
    --85544892(+) GATCAC/TGAAGA 4 -- ds50010--------
    rs1849118151,2
    --85544904(+) GAGATA/TGAGAC 4 -- ds50010--------
    rs1874008471,2
    --85545021(+) AGAATC/TGCTTG 4 -- ds50010--------
    rs1922500971,2
    --85545026(+) CGCTTA/GAACCT 4 -- ds50010--------
    rs1847349011,2
    --85545048(+) GTTGCA/GGTGAG 4 -- ds50010--------
    rs10538831,2
    C,H--85545230(-) TTTTTC/TTGAGC 4 -- ut31 ese36Minor allele frequency- T:0.00MN NS EA NA 604
    rs1895079651,2
    --85545304(+) AATTAC/TAGTTA 4 -- ut310--------
    rs1505049631,2
    --85545351(+) ACAGTA/GACCAT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for TGOLN2 (85545146 - 85555548 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TGOLN2
         1 CNV: 9953
         1 Inversion: 59896

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TGOLN2 for disorders           About GeneDecksing

    OMIM gene information: 603062    OMIM disorders: --

    6 diseases for TGOLN2:    About MalaCards
    herpes simplex    stomatitis    cholesterol    retinitis
    melanoma    hiv type 1

    Human Genome Epidemiology (HuGE) Navigator: TGOLN2 (1 document)

    Export disorders for TGOLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGOLN2 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with TGOLN2)
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    1. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. (PubMed id 9422759)1, 2, 3, 9 Kain R.... Fukuda M. (1998)
    2. VPg-primed RNA synthesis of norovirus RNA-dependent RN A polymerases by using a novel cell-based assay. (PubMed id 21994457)1, 3 Subba-Reddy C.V....Kao C.C. (2011)
    3. Primate homologues of rat TGN38: primary structure, expression and functional implications. (PubMed id 8907712)1, 2 Ponnambalam S.... Warren G. (1996)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Macrophage bridging conduit trafficking of HIV-1 throu gh the endoplasmic reticulum and Golgi network. (PubMed id 21563830)1 Kadiu I. and Gendelman H.E. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin. (PubMed id 21900423)1 Petit S.J....Towers G.J. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinucle ar compartment. (PubMed id 20386718)1 Dube M....Cohen E.A. (2010)
    10. Association of coagulation factor XIII-A with Golgi p roteins within monocyte-macrophages: implications for subcellular trafficking a nd secretion. (PubMed id 20086247)1 Cordell P.A....Grant P.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10618 HGNC: 15450 AceView: TGOLN2 Ensembl:ENSG00000152291 euGenes: HUgn10618
    ECgene: TGOLN2 H-InvDB: TGOLN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGOLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGOLN2 gene:
    Search GeneIP for patents involving TGOLN2

    GeneCards and IP:
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