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Aliases for TGOLN2 Gene

Aliases for TGOLN2 Gene

  • Trans-Golgi Network Protein 2 2 3
  • TGN46 3 4 6
  • Trans-Golgi Network Protein TGN51 3 4
  • TGN38 Homolog 3 4
  • TGN38 3 6
  • TGN48 3 4
  • TGN51 3 4
  • Trans-Golgi Network Protein (46, 48, 51kD Isoforms) 3
  • Trans-Golgi Network Integral Membrane Protein 2 3
  • Trans-Golgi Network Protein (46 2
  • 51kD Isoforms) 2
  • TTGN2 3
  • 48 2

External Ids for TGOLN2 Gene

Previous GeneCards Identifiers for TGOLN2 Gene

  • GC02M085444
  • GC02M085843
  • GC02M085506
  • GC02M085523
  • GC02M085519
  • GC02M085456
  • GC02M085398
  • GC02M085538
  • GC02M085442

Summaries for TGOLN2 Gene

Entrez Gene Summary for TGOLN2 Gene

  • This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TGOLN2 Gene

TGOLN2 (Trans-Golgi Network Protein 2) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding.

UniProtKB/Swiss-Prot for TGOLN2 Gene

  • May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Wiki entry for TGOLN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGOLN2 Gene

Genomics for TGOLN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TGOLN2 Gene

85,318,018 bp from pter
85,328,425 bp from pter
10,408 bases
Minus strand

Genomic View for TGOLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGOLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGOLN2 Gene

Proteins for TGOLN2 Gene

  • Protein details for TGOLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-Golgi network integral membrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R686
    • B8ZZ88
    • D6W5K3
    • F8WBK2
    • O15282
    • O43492
    • O43499
    • O43500
    • O43501
    • Q53G68
    • Q53GV2
    • Q6MZV1
    • Q6ZTM7
    • Q8N6T8
    • Q92760
    • Q96QL2

    Protein attributes for TGOLN2 Gene

    480 amino acids
    Molecular mass:
    51113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TGOLN2 Gene

neXtProt entry for TGOLN2 Gene

Proteomics data for TGOLN2 Gene at MOPED

Post-translational modifications for TGOLN2 Gene

  • Glycosylation at Ser36, Asn39, Ser41, Thr42, Ser45, Ser47, Ser53, Thr54, Ser56, Thr62, Asn82, Asn96, Thr118, Thr119, Ser122, Thr123, Ser124, Ser126, Thr132, Ser136, Thr137, Asn152, Asn180, Thr202, Asn208, Asn222, Ser236, Ser245, Ser263, Ser267, Ser270, Ser290, Thr318, Asn373, and Asn377
  • Modification sites at PhosphoSitePlus

Other Protein References for TGOLN2 Gene

Antibody Products

No data available for DME Specific Peptides for TGOLN2 Gene

Domains for TGOLN2 Gene

Protein Domains for TGOLN2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TGOLN2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TGOLN2 Gene

Function for TGOLN2 Gene

Molecular function for TGOLN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Ontology (GO) - Molecular Function for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with TGOLN2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGOLN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TGOLN2 Gene

Localization for TGOLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGOLN2 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.

Subcellular locations from

Jensen Localization Image for TGOLN2 Gene COMPARTMENTS Subcellular localization image for TGOLN2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 4
endosome 3
extracellular 3
endoplasmic reticulum 2
lysosome 2
vacuole 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IDA 18166528
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TGOLN2: view

Compounds for TGOLN2 Gene

(2) Novoseek inferred chemical compound relationships for TGOLN2 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 72.1 3
tyrosine 5.41 5
genes like me logo Genes that share compounds with TGOLN2: view

Transcripts for TGOLN2 Gene

Unigene Clusters for TGOLN2 Gene

Trans-golgi network protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGOLN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGOLN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP3: -
SP4: -
SP5: - - - - - -

Relevant External Links for TGOLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGOLN2 Gene

mRNA expression in normal human tissues for TGOLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TGOLN2 Gene

This gene is overexpressed in Nasal epithelium (49.4) and Serum (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGOLN2 Gene

SOURCE GeneReport for Unigene cluster for TGOLN2 Gene Hs.593382

mRNA Expression by UniProt/SwissProt for TGOLN2 Gene

Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells
genes like me logo Genes that share expressions with TGOLN2: view

Expression partners for TGOLN2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TGOLN2 Gene

Orthologs for TGOLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGOLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGOLN2 35
  • 98.92 (n)
  • 97.91 (a)
  • 98 (a)
(Mus musculus)
Mammalia Tgoln1 16
Tgoln1 36
  • 43 (a)
(Bos Taurus)
Mammalia TGOLN2 36
  • 44 (a)
(Canis familiaris)
Mammalia TGOLN2 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia TGOLN2 36
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
-- 36
  • 33 (a)
Species with no ortholog for TGOLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGOLN2 Gene

Gene Tree for TGOLN2 (if available)
Gene Tree for TGOLN2 (if available)

Paralogs for TGOLN2 Gene

No data available for Paralogs for TGOLN2 Gene

Variants for TGOLN2 Gene

Sequence variations from dbSNP and Humsavar for TGOLN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3637 -- 85,322,751(-) CTTTT(C/T)TCCCC missense, reference, intron-variant
rs7428 -- 85,318,367(-) GCTGT(A/G)TAGTA utr-variant-3-prime
rs11819 -- 85,318,423(+) TTGCA(G/T)AACTA utr-variant-3-prime
rs16346 -- 85,318,827(+) TTCCC(-/CT)GAGTC utr-variant-3-prime
rs1044958 -- 85,327,945(-) GTTGC(A/C)TTGGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TGOLN2 Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV Gain 17160897
esv1004049 OTHER Inversion 20482838
dgv79e19 OTHER Inversion 19470904
nsv818063 CNV Loss 17921354

Relevant External Links for TGOLN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGOLN2 Gene

Disorders for TGOLN2 Gene

Relevant External Links for TGOLN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TGOLN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TGOLN2 Gene

Publications for TGOLN2 Gene

  1. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. (PMID: 9422759) Kain R. … Fukuda M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Primate homologues of rat TGN38: primary structure, expression and functional implications. (PMID: 8907712) Ponnambalam S. … Warren G. (J. Cell Sci. 1996) 3 4
  3. SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. (PMID: 18166528) Ginger R.S. … Green M.R. (J. Biol. Chem. 2008) 3 23
  4. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. (PMID: 21994457) Subba-Reddy C.V. … Kao C.C. (J. Virol. 2011) 2 3
  5. Case-control association study of TGOLN2 in attempted suicide. (PMID: 20468057) Mahon P.B. … Willour V.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48

Products for TGOLN2 Gene

Sources for TGOLN2 Gene

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