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Aliases for TGOLN2 Gene

Aliases for TGOLN2 Gene

  • Trans-Golgi Network Protein 2 2 3 5
  • Trans-Golgi Network Protein (46, 48, 51kD Isoforms) 2 3
  • Trans-Golgi Network Protein TGN51 3 4
  • TGN38 Homolog 3 4
  • TGN46 3 4
  • TGN48 3 4
  • TGN51 3 4
  • Trans-Golgi Network Integral Membrane Protein 2 3
  • TGN38 3
  • TTGN2 3

External Ids for TGOLN2 Gene

Previous GeneCards Identifiers for TGOLN2 Gene

  • GC02M085444
  • GC02M085843
  • GC02M085506
  • GC02M085523
  • GC02M085519
  • GC02M085456
  • GC02M085398
  • GC02M085538
  • GC02M085442

Summaries for TGOLN2 Gene

Entrez Gene Summary for TGOLN2 Gene

  • This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TGOLN2 Gene

TGOLN2 (Trans-Golgi Network Protein 2) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network.

UniProtKB/Swiss-Prot for TGOLN2 Gene

  • May be involved in regulating membrane traffic to and from trans-Golgi network.

Gene Wiki entry for TGOLN2 Gene

Additional gene information for TGOLN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGOLN2 Gene

Genomics for TGOLN2 Gene

Regulatory Elements for TGOLN2 Gene

Enhancers for TGOLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H085308 1.2 Ensembl ENCODE dbSUPER 20.9 +18.6 18576 2.6 SAP130 ARID4B EBF1 TEAD3 ZNF366 POLR2A FOS PAF1 GATAD2A SOX5 TGOLN2 RETSAT ELMOD3 CAPG LOC100996506 GC02M085296
GH02H085306 1.5 Ensembl ENCODE dbSUPER 14.2 +21.0 20969 2 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 PAF1 SP5 ZHX2 TGOLN2 RETSAT ELMOD3 CAPG TCF7L1 LOC100996506 GC02M085296
GH02H085432 1.7 FANTOM5 ENCODE dbSUPER 11.1 -108.0 -107986 7.7 SIN3A YY1 ZNF766 ELK1 ZNF143 ZNF207 RUNX3 SP3 REST ZNF592 SH2D6 MAT2A CAPG TGOLN2 KCMF1 ENSG00000207207 RNU7-64P
GH02H085311 0.9 ENCODE dbSUPER 20.7 +15.1 15052 3.3 PAF1 TAL1 NR2F1 CEBPB THRB RARA POLR2A NR2F6 FOS RXRB TGOLN2 ELMOD3 RETSAT LOC100996506 GC02M085296
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TGOLN2 on UCSC Golden Path with GeneCards custom track

Promoters for TGOLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119552 1025 3201 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Locations for TGOLN2 Gene

Genomic Locations for TGOLN2 Gene
10,408 bases
Minus strand

Genomic View for TGOLN2 Gene

Genes around TGOLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGOLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGOLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGOLN2 Gene

Proteins for TGOLN2 Gene

  • Protein details for TGOLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-Golgi network integral membrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R686
    • B8ZZ88
    • D6W5K3
    • F8WBK2
    • O15282
    • O43492
    • O43499
    • O43500
    • O43501
    • Q53G68
    • Q53GV2
    • Q6MZV1
    • Q6ZTM7
    • Q8N6T8
    • Q92760
    • Q96QL2

    Protein attributes for TGOLN2 Gene

    480 amino acids
    Molecular mass:
    51113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TGOLN2 Gene

neXtProt entry for TGOLN2 Gene

Post-translational modifications for TGOLN2 Gene

  • Glycosylation at Ser36, Asn39, Ser56, posLast=6262, Asn82, posLast=9696, Thr118, Ser126, posLast=132132, Asn152, Asn180, posLast=202202, posLast=208208, posLast=222222, posLast=236236, Ser263, posLast=267267, Ser270, Ser290, posLast=318318, posLast=373373, and posLast=377377
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TGOLN2 Gene

Domains & Families for TGOLN2 Gene

Gene Families for TGOLN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for TGOLN2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TGOLN2: view

No data available for UniProtKB/Swiss-Prot for TGOLN2 Gene

Function for TGOLN2 Gene

Molecular function for TGOLN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulating membrane traffic to and from trans-Golgi network.

Phenotypes From GWAS Catalog for TGOLN2 Gene

Gene Ontology (GO) - Molecular Function for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with TGOLN2: view

Phenotypes for TGOLN2 Gene

genes like me logo Genes that share phenotypes with TGOLN2: view

miRNA for TGOLN2 Gene

miRTarBase miRNAs that target TGOLN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TGOLN2 Gene

Localization for TGOLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGOLN2 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGOLN2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
extracellular 3
cytosol 3
lysosome 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA 22797923
GO:0005802 trans-Golgi network IEA,IDA 18166528
genes like me logo Genes that share ontologies with TGOLN2: view

Pathways & Interactions for TGOLN2 Gene

genes like me logo Genes that share pathways with TGOLN2: view

Gene Ontology (GO) - Biological Process for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IBA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with TGOLN2: view

No data available for SIGNOR curated interactions for TGOLN2 Gene

Drugs & Compounds for TGOLN2 Gene

(2) Drugs for TGOLN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TGOLN2: view

Transcripts for TGOLN2 Gene

Unigene Clusters for TGOLN2 Gene

Trans-golgi network protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGOLN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP3: -
SP4: -
SP5: - - - - - -

Relevant External Links for TGOLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGOLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGOLN2 Gene

Protein differential expression in normal tissues from HIPED for TGOLN2 Gene

This gene is overexpressed in Nasal epithelium (49.4) and Serum (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TGOLN2 Gene

Protein tissue co-expression partners for TGOLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TGOLN2 Gene:


SOURCE GeneReport for Unigene cluster for TGOLN2 Gene:


mRNA Expression by UniProt/SwissProt for TGOLN2 Gene:

Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.

Evidence on tissue expression from TISSUES for TGOLN2 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Kidney(3.6)
  • Intestine(3)
  • Skin(3)
  • Lung(2.7)
  • Pancreas(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with TGOLN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGOLN2 Gene

Orthologs for TGOLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGOLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGOLN2 33 34
  • 98.92 (n)
(Bos Taurus)
Mammalia TGOLN2 34
  • 44 (a)
(Mus musculus)
Mammalia Tgoln1 34
  • 43 (a)
(Canis familiaris)
Mammalia TGOLN2 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia TGOLN2 34
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
-- 34
  • 33 (a)
Species where no ortholog for TGOLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGOLN2 Gene

Gene Tree for TGOLN2 (if available)
Gene Tree for TGOLN2 (if available)

Paralogs for TGOLN2 Gene

No data available for Paralogs for TGOLN2 Gene

Variants for TGOLN2 Gene

Sequence variations from dbSNP and Humsavar for TGOLN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000521781 -- 85,323,603(+) AAAAC(A/C)CTTAA intron-variant
rs1000611066 -- 85,328,306(+) TCACT(A/C)GGGGC upstream-variant-2KB
rs1000738356 -- 85,323,874(+) TTCCT(A/G)CTTAG intron-variant
rs1001130428 -- 85,330,088(+) TCTCC(A/G)TCTCC upstream-variant-2KB
rs1001134820 -- 85,322,221(+) CACAT(C/G/T)CCCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TGOLN2 Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV gain 17160897
nsv818063 CNV loss 17921354
nsv474016 CNV novel sequence insertion 20440878
nsv1147067 OTHER inversion 26484159
nsv1116466 OTHER inversion 24896259
esv3575266 CNV gain 25503493
esv1004049 OTHER inversion 20482838
dgv89e19 OTHER inversion 19470904

Variation tolerance for TGOLN2 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.93; 87.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGOLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGOLN2 Gene

Disorders for TGOLN2 Gene

Relevant External Links for TGOLN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TGOLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGOLN2 Gene

Publications for TGOLN2 Gene

  1. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. (PMID: 9422759) Kain R … Fukuda M (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. (PMID: 21994457) Subba-Reddy CV … Kao CC (Journal of virology 2011) 2 3 60
  3. Case-control association study of TGOLN2 in attempted suicide. (PMID: 20468057) Mahon PB … Willour VL (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  4. SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. (PMID: 18166528) Ginger RS … Green MR (The Journal of biological chemistry 2008) 3 22 60
  5. Primate homologues of rat TGN38: primary structure, expression and functional implications. (PMID: 8907712) Ponnambalam S … Warren G (Journal of cell science 1996) 3 4 60

Products for TGOLN2 Gene

Sources for TGOLN2 Gene

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