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Aliases for TGOLN2 Gene

Aliases for TGOLN2 Gene

  • Trans-Golgi Network Protein 2 2 3
  • Trans-Golgi Network Protein TGN51 3 4
  • TGN38 Homolog 3 4
  • TGN46 3 4
  • TGN48 3 4
  • TGN51 3 4
  • Trans-Golgi Network Protein (46, 48, 51kD Isoforms) 3
  • Trans-Golgi Network Protein (46 2
  • 51kD Isoforms) 2
  • TGN38 3
  • TTGN2 3
  • 48 2

External Ids for TGOLN2 Gene

Previous GeneCards Identifiers for TGOLN2 Gene

  • GC02M085444
  • GC02M085843
  • GC02M085506
  • GC02M085523
  • GC02M085519
  • GC02M085456
  • GC02M085398
  • GC02M085538
  • GC02M085442

Summaries for TGOLN2 Gene

Entrez Gene Summary for TGOLN2 Gene

  • This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TGOLN2 Gene

TGOLN2 (Trans-Golgi Network Protein 2) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding.

UniProtKB/Swiss-Prot for TGOLN2 Gene

  • May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Wiki entry for TGOLN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGOLN2 Gene

Genomics for TGOLN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TGOLN2 Gene

Chromosome:
2
Start:
85,318,018 bp from pter
End:
85,328,425 bp from pter
Size:
10,408 bases
Orientation:
Minus strand

Genomic View for TGOLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGOLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGOLN2 Gene

Proteins for TGOLN2 Gene

  • Protein details for TGOLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43493-TGON2_HUMAN
    Recommended name:
    Trans-Golgi network integral membrane protein 2
    Protein Accession:
    O43493
    Secondary Accessions:
    • B2R686
    • B8ZZ88
    • D6W5K3
    • F8WBK2
    • O15282
    • O43492
    • O43499
    • O43500
    • O43501
    • Q53G68
    • Q53GV2
    • Q6MZV1
    • Q6ZTM7
    • Q8N6T8
    • Q92760
    • Q96QL2

    Protein attributes for TGOLN2 Gene

    Size:
    480 amino acids
    Molecular mass:
    51113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TGOLN2 Gene

neXtProt entry for TGOLN2 Gene

Proteomics data for TGOLN2 Gene at MOPED

Post-translational modifications for TGOLN2 Gene

  • Glycosylation at Ser 36, Asn 39, Ser 56, Thr 62, Asn 82, Asn 96, Thr 118, Ser 126, Thr 132, Asn 152, Asn 180, Thr 202, Asn 208, Asn 222, Ser 236, Ser 263, Ser 267, Ser 270, Ser 290, Thr 318, Asn 373, and Asn 377
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TGOLN2 Gene

Domains & Families for TGOLN2 Gene

Protein Domains for TGOLN2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TGOLN2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TGOLN2 Gene

Function for TGOLN2 Gene

Molecular function for TGOLN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Ontology (GO) - Molecular Function for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with TGOLN2: view

Phenotypes for TGOLN2 Gene

GenomeRNAi human phenotypes for TGOLN2:
genes like me logo Genes that share phenotypes with TGOLN2: view

Animal Model Products

CRISPR Products

miRNA for TGOLN2 Gene

miRTarBase miRNAs that target TGOLN2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGOLN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TGOLN2 Gene

Localization for TGOLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGOLN2 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGOLN2 Gene COMPARTMENTS Subcellular localization image for TGOLN2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
nucleus 4
endosome 3
endoplasmic reticulum 2
lysosome 2
vacuole 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IDA 22797923
GO:0005802 trans-Golgi network IDA 18166528
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TGOLN2: view

Pathways & Interactions for TGOLN2 Gene

genes like me logo Genes that share pathways with TGOLN2: view

Gene Ontology (GO) - Biological Process for TGOLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IBA --
genes like me logo Genes that share ontologies with TGOLN2: view

No data available for SIGNOR curated interactions for TGOLN2 Gene

Drugs & Compounds for TGOLN2 Gene

(1) Drugs for TGOLN2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(1) Additional Compounds for TGOLN2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with TGOLN2: view

Transcripts for TGOLN2 Gene

Unigene Clusters for TGOLN2 Gene

Trans-golgi network protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGOLN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGOLN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: -
SP4: -
SP5: - - - - - -

Relevant External Links for TGOLN2 Gene

GeneLoc Exon Structure for
TGOLN2
ECgene alternative splicing isoforms for
TGOLN2

Expression for TGOLN2 Gene

mRNA expression in normal human tissues for TGOLN2 Gene

Protein differential expression in normal tissues from HIPED for TGOLN2 Gene

This gene is overexpressed in Nasal epithelium (49.4) and Serum (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGOLN2 Gene



SOURCE GeneReport for Unigene cluster for TGOLN2 Gene Hs.593382

mRNA Expression by UniProt/SwissProt for TGOLN2 Gene

O43493-TGON2_HUMAN
Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells
genes like me logo Genes that share expression patterns with TGOLN2: view

Protein tissue co-expression partners for TGOLN2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TGOLN2 Gene

Orthologs for TGOLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGOLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGOLN2 35
  • 98.92 (n)
  • 97.91 (a)
TGOLN2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgoln1 16
Tgoln1 36
  • 43 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGOLN2 36
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGOLN2 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGOLN2 36
  • 21 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
Species with no ortholog for TGOLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGOLN2 Gene

ENSEMBL:
Gene Tree for TGOLN2 (if available)
TreeFam:
Gene Tree for TGOLN2 (if available)

Paralogs for TGOLN2 Gene

No data available for Paralogs for TGOLN2 Gene

Variants for TGOLN2 Gene

Sequence variations from dbSNP and Humsavar for TGOLN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3637 -- 85,322,751(-) CTTTT(C/T)TCCCC missense, reference, intron-variant
rs7428 -- 85,318,367(-) GCTGT(A/G)TAGTA utr-variant-3-prime
rs11819 -- 85,318,423(+) TTGCA(G/T)AACTA utr-variant-3-prime
rs16346 -- 85,318,827(+) TTCCC(-/CT)GAGTC utr-variant-3-prime
rs1044958 -- 85,327,945(-) GTTGC(A/C)TTGGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TGOLN2 Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV Gain 17160897
esv1004049 OTHER Inversion 20482838
dgv79e19 OTHER Inversion 19470904
nsv818063 CNV Loss 17921354

Variation tolerance for TGOLN2 Gene

Residual Variation Intolerance Score: 85.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.93; 87.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGOLN2 Gene

HapMap Linkage Disequilibrium report
TGOLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGOLN2 Gene

Disorders for TGOLN2 Gene

Relevant External Links for TGOLN2

Genetic Association Database (GAD)
TGOLN2
Human Genome Epidemiology (HuGE) Navigator
TGOLN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGOLN2
genes like me logo Genes that share disorders with TGOLN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGOLN2 Gene

Publications for TGOLN2 Gene

  1. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. (PMID: 9422759) Kain R. … Fukuda M. (J. Biol. Chem. 1998) 2 23 67
  2. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. (PMID: 21994457) Subba-Reddy C.V. … Kao C.C. (J. Virol. 2011) 2 67
  3. Human cytomegalovirus final envelopment on membranes containing both trans-Golgi network and endosomal markers. (PMID: 19888988) Cepeda V. … Fraile-Ramos A. (Cell. Microbiol. 2010) 23 67
  4. SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. (PMID: 18166528) Ginger R.S. … Green M.R. (J. Biol. Chem. 2008) 23 67
  5. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley I.G. … Pfeffer S.R. (J. Cell Biol. 2008) 23 67

Products for TGOLN2 Gene

Sources for TGOLN2 Gene

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