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TGOLN2 Gene

protein-coding   GIFtS: 58
GCID: GC02M085538

Trans-Golgi Network Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trans-Golgi Network Protein 21 2     481
TGN462 3 5     51kD Isoforms)1
Trans-Golgi Network Protein TGN512 3     Trans-Golgi Network Protein (461
TGN482 3     TTGN22
TGN512 3     Trans-Golgi Network Integral Membrane Protein 22
TGN38 Homolog2 3     Trans-Golgi Network Protein (46, 48, 51kD Isoforms)2
TGN382 5     

External Ids:    HGNC: 154501   Entrez Gene: 106182   Ensembl: ENSG000001522917   OMIM: 6030625   UniProtKB: O434933   

Export aliases for TGOLN2 gene to outside databases

Previous GC identifers: GC02M085444 GC02M085843 GC02M085506 GC02M085523 GC02M085519 GC02M085456 GC02M085398 GC02M085442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGOLN2 Gene:
This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting
station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the
trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TGOLN2 Gene:
TGOLN2 (trans-golgi network protein 2) is a protein-coding gene. Diseases associated with TGOLN2 include herpes simplex, and hiv-1.

UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493
Function: May be involved in regulating membrane traffic to and from trans-Golgi network

Gene Wiki entry for TGOLN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGOLN2 gene promoter:
         HOXA9   HOXA9B   GATA-3   AP-2alpha isoform 3   AP-2alpha isoform 2   Meis-1a   AP-2alpha isoform 4   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGOLN2 promoter sequence
   Search Chromatin IP Primers for TGOLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGOLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TGOLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGOLN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M085538:  view genomic region     (about GC identifiers)

Start:
85,545,141 bp from pter      End:
85,555,548 bp from pter
Size:
10,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493 (See protein sequence)
Recommended Name: Trans-Golgi network integral membrane protein 2 precursor  
Size: 480 amino acids; 51113 Da
Secondary accessions: B8ZZ88 O15282 O43492 O43499 O43500 O43501 Q53G68 Q53GV2 Q6MZV1 Q6ZTM7
Q8N6T8 Q92760 Q96QL2
Alternative splicing: 6 isoforms:  O43493-1   O43493-2   O43493-3   O43493-4   O43493-5   O43493-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TGOLN2: NX_O43493

Explore proteomics data for TGOLN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser36, Asn39, Ser41, Thr42, Ser45, Ser47, Ser53, Thr54, Ser56, Thr62,
                                 Asn82, Asn96, Thr118, Thr119, Ser122, Thr123, Ser124, Ser126, Thr132, Ser136 (see all 35)
  • Modification sites at PhosphoSitePlus

  • See TGOLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193769.1  NP_001193770.1  NP_001193773.1  NP_006455.2  

    ENSEMBL proteins: 
     ENSP00000366603   ENSP00000381312   ENSP00000386443   ENSP00000387035   ENSP00000391190  
     ENSP00000282120  
    Reactome Protein details: O43493

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026084 TGN38

    Graphical View of Domain Structure for InterPro Entry O43493

    ProtoNet protein and cluster: O43493


    TGOLN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGON2_HUMAN, O43493
    Function: May be involved in regulating membrane traffic to and from trans-Golgi network

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
         
    TGOLN2 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-186-5p (MIRT045045), hsa-mir-16-5p (MIRT051296), hsa-mir-15b-5p (MIRT046476), hsa-mir-935 (MIRT036655), hsa-mir-7-5p (MIRT025778), hsa-mir-33a-5p (MIRT028198), hsa-mir-124-3p (MIRT022565)

    Block miRNA regulation of human, mouse, rat TGOLN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGOLN2 (see all 63):
    hsa-miR-579 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-624
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGOLN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGON2_HUMAN, O43493: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network
    membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the
    trans-Golgi network and the cell surface returning via endosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    nucleus4
    endosome3
    extracellular3
    endoplasmic reticulum2
    lysosome2
    vacuole2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IDA18166528
    GO:0005886plasma membrane IEA--

    TGOLN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TGOLN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TGOLN2
        Golgi Associated Vesicle Biogenesis



    TGOLN2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TGOLN2
    Interactions:

        GeneGlobe Interaction Network for TGOLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGOLN2 (O434931, 2, 3 ENSP000003666034) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINP099582, 3, ENSP000002681714MINT-3372400 I2D: score=1 STRING: ENSP00000268171
    MMP14P502812, 3, ENSP000003082084MINT-7897512 I2D: score=1 STRING: ENSP00000308208
    GGA3Q9NZ522, 3, ENSP000002455414MINT-3372421 I2D: score=1 STRING: ENSP00000245541
    IGF2RP117172, 3, ENSP000003494374MINT-3372318 I2D: score=1 STRING: ENSP00000349437
    NCSTNQ925422, 3, ENSP000002947854MINT-6174913 I2D: score=1 STRING: ENSP00000294785
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGOLN2 (TGON2)

    2 Novoseek inferred chemical compound relationships for TGOLN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 72.1 3 17914056 (2), 19888988 (1)
    tyrosine 5.41 5 10050758 (3), 9422759 (1), 8436587 (1)



    TGOLN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TGOLN2 gene (4 alternative transcripts): 
    NM_001206840.1  NM_001206841.1  NM_001206844.1  NM_006464.3  

    Unigene Cluster for TGOLN2:

    Trans-golgi network protein 2
    Hs.593382  [show with all ESTs]
    Unigene Representative Sequence: NM_001206840
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377386(uc002spb.3 uc002soz.3 uc021vjw.1 uc021vjx.1 uc002spa.3)
    ENST00000398263 ENST00000409232 ENST00000409015 ENST00000444342(uc002spc.2)
    ENST00000282120
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TGOLN2 (see all 63):
    hsa-miR-579 hsa-miR-4291 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-106a hsa-miR-128 hsa-miR-301a hsa-miR-624
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      QuantiTect SYBR Green Assays in human, mouse, rat TGOLN2
      QuantiFast Probe-based Assays in human, mouse, rat TGOLN2

    Additional mRNA sequence: 

    AF027515.1 AF027516.1 AK025557.1 AK126465.1 AK222829.1 AK223063.1 AK312479.1 AL133437.1 
    BC008461.1 BC028219.1 BC035237.1 BC046196.1 BC062782.1 BX640733.1 BX640818.1 BX640868.1 
    U62390.1 X94333.1 

    Selected DOTS entries (see all 26):

    DT.97804475  DT.97804688  DT.418916  DT.100761333  DT.114052  DT.120978787  DT.40303831  DT.100825163 
    DT.100825160  DT.100031368  DT.120978857  DT.100825158  DT.91898610  DT.95192821  DT.100800774  DT.100825165 
    DT.120978831  DT.100825166  DT.121636327  DT.100759309  DT.100809648  DT.100825157  DT.120978731  DT.92327959 

    Selected AceView cDNA sequences (see all 596):

    BM802140 BQ437366 AI440052 BQ223385 BQ052112 BF475440 AW197946 BU727257 
    CB070201 CD108293 BU196502 BF724754 AA913159 BM351900 CB139612 AI653435 
    AA983710 BQ681523 BG152880 AW504076 BU615213 CB069701 BF197755 CA391854 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TGOLN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                  -               
    SP2:                                                                  
    SP3:                                                  -               
    SP4:                                -                                 
    SP5:                          -     -     -     -     -     -         


    ECgene alternative splicing isoforms for TGOLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TGOLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGATAAAT
    TGOLN2 Expression
    About this image


    TGOLN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TGOLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGOLN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593382

    UniProtKB/Swiss-Prot: TGON2_HUMAN, O43493
    Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney.
    Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGOLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TGOLN2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgoln15 trans-golgi network protein   --   6 (32.27 cM) 72608432 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    35(a)
    33(a)
    many → 1
    many → 1
    GL343238.1(47984-54504)
    GL344758.1(4472-8956)


    ENSEMBL Gene Tree for TGOLN2 (if available)
    TreeFam Gene Tree for TGOLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGOLN2 (see all 328)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739430971,2
    C,F--85408695(+) CAGAAC/TATGGA 4 -- ds50012Minor allele frequency- T:0.15WA 120
    rs568701241,2
    C,F--85408924(+) TGGGAG/AGCCAA 4 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1928670231,2
    --85408943(+) GATCAC/TGAAGA 4 -- ds50010--------
    rs1849118151,2
    --85408955(+) GAGATA/TGAGAC 4 -- ds50010--------
    rs1874008471,2
    --85409072(+) AGAATC/TGCTTG 4 -- ds50010--------
    rs1922500971,2
    --85409077(+) CGCTTA/GAACCT 4 -- ds50010--------
    rs1847349011,2
    C--85409099(+) GTTGCA/GGTGAG 4 -- ds50010--------
    rs10538831,2
    C,H--85409281(-) TTTTTC/TTGAGC 4 -- ut31 ese36Minor allele frequency- T:0.00MN NS EA NA 604
    rs1895079651,2
    --85409355(+) AATTAC/TAGTTA 4 -- ut310--------
    rs1505049631,2
    --85409402(+) ACAGTA/GACCAT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for TGOLN2 (85545141 - 85555548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TGOLN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818063CNV Loss17921354
    nsv834282CNV Gain17160897
    esv1004049OTHER Inversion20482838
    dgv79e19OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603062    OMIM disorders: --

    8 diseases for TGOLN2:    
    About MalaCards
    herpes simplex    hiv-1    tonsillitis    retinitis
    melanoma    thyroiditis    cerebritis    prostatitis


    TGOLN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TGOLN2
    Human Genome Epidemiology (HuGE) Navigator: TGOLN2 (1 document)

    Export disorders for TGOLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGOLN2 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with TGOLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. (PubMed id 9422759)1, 2, 3, 9 Kain R.... Fukuda M. (J. Biol. Chem. 1998)
    2. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. (PubMed id 21994457)1, 3 Subba-Reddy C.V....Kao C.C. (J. Virol. 2011)
    3. Case-control association study of TGOLN2 in attempted suicide. (PubMed id 20468057)1, 4 Mahon P.B....Willour V.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Primate homologues of rat TGN38: primary structure, expression and functional implications. (PubMed id 8907712)1, 2 Ponnambalam S.... Warren G. (J. Cell Sci. 1996)
    5. SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. (PubMed id 18166528)1, 9 Ginger R.S....Green M.R. (J. Biol. Chem. 2008)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network. (PubMed id 21563830)1 Kadiu I. and Gendelman H.E. (J. Proteome Res. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin. (PubMed id 21900423)1 Petit S.J....Towers G.J. (J. Gen. Virol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10618 HGNC: 15450 AceView: TGOLN2 Ensembl:ENSG00000152291 euGenes: HUgn10618
    ECgene: TGOLN2 H-InvDB: TGOLN2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGOLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGOLN2 gene:
    Search GeneIP for patents involving TGOLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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