TGM7 Gene
protein-coding GIFtS: 47
GCID: GC15M043568
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transglutaminase 7
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Aliases
for TGM7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transglutaminase 71 2 | | TGase Z2 3 | | TGMZ1 2 5 | | EC 2.3.2.133 8 | | Transglutaminase Z2 3 | | Protein-Glutamine Gamma-Glutamyltransferase Z2 | | TG(Z)2 3 | | Transglutaminase-73 | | TGZ2 3 | | Transglutaminase-73 | | TGase-72 3 | | |
Export aliases for TGM7 gene to outside databasesPrevious GC identifers: GC15M038936 GC15M036464 GC15M041147 GC15M041284 GC15M041355 GC15M020417 |
Summaries
for TGM7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TGM7:
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilizeprotein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional backgroundinformation on transglutaminases, see TGM1 (MIM 190195).(supplied by OMIM, Jul 2002)
UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
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Genomic Views
for TGM7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGM7 gene promoter:
HOXA9 HOXA9B AML1a RelA NF-kappaB1 NF-kappaB Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGM7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q15.2TGM7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M043568: view genomic region
(about GC identifiers)
Start:
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43,568,478 bp from pter |
End:
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43,594,453 bp from pter |
Size:
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25,976 bases |
Orientation:
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minus strand |
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Proteins
for TGM7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1 (See
protein sequence)Recommended Name: Protein-glutamine gamma-glutamyltransferase Z Size: 710 amino acids; 79941 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)Explore the universe of human proteins at neXtProt for TGM7: NX_Q96PF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PF1
3 DME Specific Peptides for TGM7 (Q96PF1)
TGM7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443187.1
ENSEMBL proteins: ENSP00000389466
Human Recombinant Protein Products:
TGM7 Antibody Products:
Assay Products for TGM7: |
Protein
Domains /
Families
for TGM7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGM7 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q96PF1ProtoNet protein and cluster: Q96PF1 1 Blocks protein family: IPB002931 Transglutaminase-like domain
UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family |
Function
for TGM7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteinsCatalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)Enzyme Number (IUBMB): EC 2.3.2.131 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGM7 (NM_052955) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
TGM7 for ontologies About GeneDecksing
|
Pathways & Interactions
for TGM7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGM7
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018149 | peptide cross-linking |
IEA | -- |
TGM7 for ontologies About GeneDecksing
|
Drugs & Compounds
for TGM7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGM7
2 HMDB Compounds for TGM7 About this table
1 DrugBank Compound for TGM7 About this table
Search CenterWatch for drugs/clinical trials and news about TGM7
|
Transcripts
for TGM7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGM7 gene: NM_052955.2 Unigene Cluster for TGM7: Transglutaminase 7 Hs.164661 [show with all ESTs]Unigene Representative Sequence: AF3633932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000562372 ENST00000452443(uc001zrf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TGM7 (NM_052955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM7 |
Additional cDNA sequence: AF363393.1 1 DOTS entry: DT.306607 8 AceView cDNA sequences: AF363393 NM_052955 AI024635 BX112796 AW511368 AI018564 AI243131 AA027266
GeneLoc Exon Structure
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Expression
for TGM7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCCTCAC
About this image
See TGM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGM7
SOURCE GeneReport for Unigene cluster: Hs.164661
UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for TGM7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7 |
Orthologs
for TGM7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TGM7 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for TGM7 (if available)
TreeFam Gene Tree for TGM7 (if available) |
Paralogs
for TGM7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGM7 gene
- EPB422 TGM12 TGM52 TGM42 TGM32 F13A12 TGM22 TGM62
8 SIMAP similar genes for TGM7 using alignment to 2 protein entries: TGM7_HUMAN (see all proteins):TGM5 TGM3 TGM6 TGM2 TGM4 TGM1
F13A1 EPB42
TGM7 for paralogs About GeneDecksing
|
Genomic Variants
for TGM7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGM7 (43568478 - 43594453 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGM7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM7 |
|
Disorders
/ Diseases
for TGM7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGM7 for disorders About GeneDecksing
OMIM gene information: 606776
OMIM disorders: --
3  diseases for TGM7: About MalaCardsbreast cancer immunodeficiency thyroiditis
Export disorders for TGM7 gene to outside databases
|
Publications
for TGM7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGM7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TGM7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PubMed id 11390390)1, 2, 3, 9 Grenard P....Aeschlimann D. (2001)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. (PubMed id 7906657)1 Amendola A....Piacentini M. (1994)
- Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro. (PubMed id 7688299)1 Mariniello L....Porta R. (1993)
- A plasminogen-like protein, present in the apical ext racellular environment of thyroid epithelial cells, degrades thyroglobulin in v itro. (PubMed id 16259961)9 Giraud A....Mallet B. (2005)
- Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. (PubMed id 16786148)9 Martin T.A....Jiang W.G. (2006)
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External Searches for TGM7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TGM7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGM7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGM7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TGM7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TGM7 gene:
Search GeneIP for patents involving TGM7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGM7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TGM7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGM7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM7 | | | OriGene Protein Over-expression Lysate for TGM7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TGM7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TGM7 | | OriGene Custom Protein Services for TGM7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGM7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM7 |
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| | | | Search Tocris compounds for TGM7 |
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 | | | TGM7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7 |
|  |  |  | | | | Search ThermoFisher Antibodies for TGM7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM7 |
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