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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGM7 Gene

protein-coding   GIFtS: 46
GCID: GC15M043568

Transglutaminase 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transglutaminase 71 2     EC 2.3.2.133 8
Transglutaminase Z1 2 3     TGMZ2 5
TG(Z)2 3     Protein-Glutamine Gamma-Glutamyltransferase Z2
TGZ2 3     transglutaminase-72
TGase-72 3     Transglutaminase-73
TGase Z2 3     

External Ids:    HGNC: 307901   Entrez Gene: 1161792   Ensembl: ENSG000001594957   OMIM: 6067765   UniProtKB: Q96PF13   

Export aliases for TGM7 gene to outside databases

Previous GC identifers: GC15M038936 GC15M036464 GC15M041147 GC15M041284 GC15M041355 GC15M020417


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGM7 Gene:
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize
protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background
information on transglutaminases, see TGM1 (MIM 190195).(supplied by OMIM, Jul 2002)

GeneCards Summary for TGM7 Gene: 
TGM7 (transglutaminase 7) is a protein-coding gene. Diseases associated with TGM7 include thyroiditis, and breast cancer. GO annotations related to this gene include metal ion binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM3.

UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGM7 gene promoter:
         HOXA9   HOXA9B   AML1a   RelA   NF-kappaB1   NF-kappaB   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15.2

TGM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043568:  view genomic region     (about GC identifiers)

Start:
43,568,478 bp from pter      End:
43,594,453 bp from pter
Size:
25,976 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase Z  
Size: 710 amino acids; 79941 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)

Explore the universe of human proteins at neXtProt for TGM7: NX_Q96PF1

Explore proteomics data for TGM7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PF1

  • 3 DME Specific Peptides for TGM7 (Q96PF1)
     YKYPEGS  PEGSPEER  YGQCWVFA 

    TGM7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TGM7 Protein Expression
    REFSEQ proteins: NP_443187.1  
    ENSEMBL proteins: 
     ENSP00000389466  

    Human Recombinant Protein Products for TGM7: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TGM: Transglutaminases

    5/7 InterPro protein domains (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry Q96PF1

    ProtoNet protein and cluster: Q96PF1

    1 Blocks protein domain: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    TGM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGM7_HUMAN, Q96PF1
    Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

         Enzyme Number (IUBMB): EC 2.3.2.131 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003810protein-glutamine gamma-glutamyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    TGM7 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGM7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018149peptide cross-linking IEA--

    TGM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGM7

    2 HMDB Compounds for TGM7    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for TGM7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about TGM7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TGM7 gene: 
    NM_052955.2  

    Unigene Cluster for TGM7:

    Transglutaminase 7
    Hs.164661  [show with all ESTs]
    Unigene Representative Sequence: AF363393
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562372 ENST00000452443(uc001zrf.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: AF363393.1 

    1 DOTS entry:

    DT.306607 

    8 AceView cDNA sequences:

    BX112796 NM_052955 AF363393 AI024635 AW511368 AI018564 AI243131 AA027266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCCTCAC
    TGM7 Expression
    About this image


    See TGM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGM7

    SOURCE GeneReport for Unigene cluster: Hs.164661

    UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for TGM7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TGM7 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgm71 , 5 transglutaminase 71, 5 82.23(n)1
    78.14(a)1
      2 (60.37 cM)5
    6405431  NM_001160424.11  NP_001153896.11 
     1210935655 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    possible ortholog
    2(94287866-94299074)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    possible ortholog
    4(46352835-46372710)
    zebrafish
    (Danio rerio)
    Actinopterygii tgm5l6
    transglutaminase 5, like
    34(a)
    possible ortholog
    Zv9_scaffold3522(24531-41501)


    ENSEMBL Gene Tree for TGM7 (if available)
    TreeFam Gene Tree for TGM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGM7 gene
    TGM32  F13A12  TGM12  EPB422  TGM52  TGM42  TGM22  TGM62  
    8 SIMAP similar genes for TGM7 using alignment to 2 protein entries:     TGM7_HUMAN (see all proteins):
    TGM5    TGM3    TGM6    TGM2    TGM4    TGM1
    F13A1    EPB42

    TGM7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 SNPs in TGM7 are shown (see all 589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475802181,2
    --43568029(+) AAGGCG/TGGGAC 1 -- ds50010--------
    rs1419835911,2
    --43568038(+) ACAGGA/GATAGC 1 -- ds50010--------
    rs1164247401,2
    --43568205(+) ACAGGA/GTCGCT 1 -- ds50010--------
    rs4735541,2
    C,F,O,A,H--43568207(-) ACAGCA/GACCCT 1 -- ds500121Minor allele frequency- G:0.48NS EA NA WA CSA 1107
    rs71801111,2
    C,F--43568233(+) AAACCG/ACCCTC 1 -- ds50012Minor allele frequency- A:0.15CSA WA 120
    rs1116983051,2
    F--43568350(+) GGCTTA/GTTTTG 1 -- ds50012Minor allele frequency- G:0.06CSA WA 120
    rs1844933631,2
    --43568516(+) GCACAC/TGGTGT 1 -- ut310--------
    rs1875393441,2
    --43568552(+) AGGCAA/GGCTAG 1 -- ut310--------
    rs64930801,2
    C,F,A,H--43568583(+) CAAGAC/TGACAT 1 -- ut3115Minor allele frequency- T:0.07NS EA NA CSA WA 1446
    rs790712031,2
    C--43568611(+) AGCCAA/GGTGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TGM7 (43568478 - 43594453 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TGM7: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TGM7
    DNA2.0 Custom Variant and Variant Library Synthesis for TGM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606776    OMIM disorders: --

    2 diseases for TGM7:    About MalaCards
    thyroiditis    breast cancer


    TGM7 for disorders           About GeneDecksing


    Export disorders for TGM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGM7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TGM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PubMed id 11390390)1, 2, 3, 9 Grenard P....Aeschlimann D. (2001)
    2. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    3. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    4. HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. (PubMed id 7906657)1 Amendola A....Piacentini M. (1994)
    5. Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro. (PubMed id 7688299)1 Mariniello L....Porta R. (1993)
    6. A plasminogen-like protein, present in the apical ext racellular environment of thyroid epithelial cells, degrades thyroglobulin in v itro. (PubMed id 16259961)9 Giraud A....Mallet B. (2005)
    7. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. (PubMed id 16786148)9 Martin T.A....Jiang W.G. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116179 HGNC: 30790 AceView: TGM7 Ensembl:ENSG00000159495 euGenes: HUgn116179
    ECgene: TGM7 H-InvDB: TGM7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TGM7 gene:
    Search GeneIP for patents involving TGM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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