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TGM7 Gene

protein-coding   GIFtS: 46
GCID: GC15M043568

Transglutaminase 7

  Search for TGM7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transglutaminase 71 2     EC 2.3.2.133 8
Transglutaminase Z1 2 3     TGMZ2 5
TG(Z)2 3     Protein-Glutamine Gamma-Glutamyltransferase Z2
TGZ2 3     transglutaminase-72
TGase-72 3     Transglutaminase-73
TGase Z2 3     

External Ids:    HGNC: 307901   Entrez Gene: 1161792   Ensembl: ENSG000001594957   OMIM: 6067765   UniProtKB: Q96PF13   

Export aliases for TGM7 gene to outside databases

Previous GC identifers: GC15M038936 GC15M036464 GC15M041147 GC15M041284 GC15M041355 GC15M020417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGM7 Gene:
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize
protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background
information on transglutaminases, see TGM1 (MIM 190195).(supplied by OMIM, Jul 2002)

GeneCards Summary for TGM7 Gene:
TGM7 (transglutaminase 7) is a protein-coding gene. GO annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM3.

UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGM7 gene promoter:
         HOXA9   HOXA9B   AML1a   RelA   NF-kappaB1   NF-kappaB   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGM7 promoter sequence
   Search Chromatin IP Primers for TGM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15.2

TGM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043568:  view genomic region     (about GC identifiers)

Start:
43,568,478 bp from pter      End:
43,594,453 bp from pter
Size:
25,976 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase Z  
Size: 710 amino acids; 79941 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)

Explore the universe of human proteins at neXtProt for TGM7: NX_Q96PF1

Explore proteomics data for TGM7 at MOPED

3 DME Specific Peptides for TGM7 (Q96PF1)
 YKYPEGS  PEGSPEER  YGQCWVFA 


See TGM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_443187.1  
ENSEMBL proteins: 
 ENSP00000389466  

TGM7 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TGM: Transglutaminases

Selected InterPro protein domains (see all 7):
 IPR008958 Transglutaminase_C
 IPR014756 Ig_E-set
 IPR023608 Gln_gamma-glutamylTfrase_euk
 IPR001102 Transglutaminase_N
 IPR013808 Transglutaminase_CS

Graphical View of Domain Structure for InterPro Entry Q96PF1

ProtoNet protein and cluster: Q96PF1

1 Blocks protein domain: IPB002931 Transglutaminase-like domain

UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


Find genes that share domains with TGM7           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TGM7_HUMAN, Q96PF1
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

     Enzyme Number (IUBMB): EC 2.3.2.131 2

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003810protein-glutamine gamma-glutamyltransferase activity IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with TGM7           About GenesLikeMe


Animal Models:
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hsa-mir-148b-3p (MIRT019276)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TGM7
Interactions:

    Search GeneGlobe Interaction Network for TGM7

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0018149peptide cross-linking IEA--

Find genes that share ontologies with TGM7           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TGM7

2 HMDB Compounds for TGM7    About this table
CompoundSynonyms CAS #PubMed Ids
AmmoniaNH3 (see all 31)7664-41-7--
CalciumCa (see all 2)7440-70-2--

1 DrugBank Compound for TGM7    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TGM7 gene: 
NM_052955.2  

Unigene Cluster for TGM7:

Transglutaminase 7
Hs.164661  [show with all ESTs]
Unigene Representative Sequence: AF363393
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000562372 ENST00000452443(uc001zrf.1)
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Additional mRNA sequence: AF363393.1 

1 DOTS entry:

DT.306607 

8 AceView cDNA sequences:

AF363393 BX112796 AI024635 NM_052955 AW511368 AI018564 AI243131 AA027266 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TGM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCACCCTCAC
TGM7 Expression
About this image

TGM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TGM7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.164661

UniProtKB/Swiss-Prot: TGM7_HUMAN, Q96PF1
Tissue specificity: Widely expressed

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TGM7 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tgm71 , 5 transglutaminase 71, 5 82.23(n)1
78.14(a)1
  2 (60.37 cM)5
6405431  NM_001160424.11  NP_001153896.11 
 1210935655 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
51(a)
many ↔ many
20(7006419-7021548)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
35(a)
34(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
4(46352835-46372710)
GL344116.1(42151-47725)
zebrafish
(Danio rerio)
Actinopterygii tgm86
transglutaminase 8
37(a)
1 → many
6(59700726-59704992) ENSDARG00000097651


ENSEMBL Gene Tree for TGM7 (if available)
TreeFam Gene Tree for TGM7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TGM7 gene
TGM32  F13A12  TGM12  EPB422  TGM52  TGM42  TGM22  TGM62  
8 SIMAP similar genes for TGM7 using alignment to 2 protein entries:     TGM7_HUMAN (see all proteins):
TGM5    TGM3    TGM6    TGM2    TGM4    TGM1
F13A1    EPB42

Find genes that share paralogs with TGM7           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TGM7 (see all 589)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1475802181,2
--43568029(+) AAGGCG/TGGGAC 1 -- ds50010--------
rs1419835911,2
--43568038(+) ACAGGA/GATAGC 1 -- ds50010--------
rs1164247401,2
--43568205(+) ACAGGA/GTCGCT 1 -- ds50010--------
rs4735541,2
C,F,O,A,H--43568207(-) ACAGCA/GACCCT 1 -- ds500121Minor allele frequency- G:0.48NS EA NA WA CSA 1107
rs71801111,2
C,F--43568233(+) AAACCG/ACCCTC 1 -- ds50012Minor allele frequency- A:0.15CSA WA 120
rs1116983051,2
F--43568350(+) GGCTTA/GTTTTG 1 -- ds50012Minor allele frequency- G:0.06CSA WA 120
rs1844933631,2
--43568516(+) GCACAC/TGGTGT 1 -- ut310--------
rs1875393441,2
--43568552(+) AGGCAA/GGCTAG 1 -- ut310--------
rs64930801,2
C,F,A,H--43568583(+) CAAGAC/TGACAT 1 -- ut3115Minor allele frequency- T:0.07NS EA NA CSA WA 1446
rs790712031,2
C--43568611(+) AGCCAA/GGTGGG 1 -- ut310--------

HapMap Linkage Disequilibrium report for TGM7 (43568478 - 43594453 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TGM7: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TGM7
DNA2.0 Custom Variant and Variant Library Synthesis for TGM7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606776    OMIM disorders: --


Find genes that share disorders with TGM7           About GenesLikeMe


Export disorders for TGM7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TGM7 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TGM7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PubMed id 11390390)1, 2, 3, 9 Grenard P.... Aeschlimann D. (J. Biol. Chem. 2001)
  2. Phage-displayed peptide library screening for preferred human substrate peptide sequences for transglutaminase 7. (PubMed id 23876241)1 Kuramoto K....Hitomi K. (Arch. Biochem. Biophys. 2013)
  3. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
  4. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
  5. HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. (PubMed id 7906657)1 Amendola A....Piacentini M. (FEBS Lett. 1994)
  6. Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro. (PubMed id 7688299)1 Mariniello L....Porta R. (Eur. J. Biochem. 1993)
  7. A plasminogen-like protein, present in the apical extracellular environment of thyroid epithelial cells, degrades thyroglobulin in vitro. (PubMed id 16259961)9 Giraud A....Mallet B. (Biochem. Biophys. Res. Commun. 2005)
  8. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. (PubMed id 16786148)9 Martin T.A....Jiang W.G. (Oncol. Rep. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116179 HGNC: 30790 AceView: TGM7 Ensembl:ENSG00000159495 euGenes: HUgn116179
ECgene: TGM7 H-InvDB: TGM7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TGM7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TGM7 gene:
Search GeneIP for patents involving TGM7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat TGM7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TGM7
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 Custom PCR Arrays for TGM7 Search Chromatin IP Primers for TGM7
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 GenScript Custom Purified and Recombinant Proteins Services for TGM7 GenScript cDNA clones with any tag delivered in your preferred vector for TGM7
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 Search Tocris compounds for TGM7
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for TGM7
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM7
 SwitchGear 3'UTR luciferase reporter plasmids for TGM7
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM7
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGM7
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 Search Addgene for plasmids for TGM7
  Search eBioscience for proteins for TGM7
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  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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