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Aliases for TGM5 Gene

Aliases for TGM5 Gene

  • Transglutaminase 5 2 3 5
  • Transglutaminase X 3 4
  • Transglutaminase-5 3 4
  • EC 4 63
  • TGase X 3 4
  • TGase-5 3 4
  • TG(X) 3 4
  • TGMX 3 4
  • TGX 3 4
  • Transglutaminase V 3
  • TGASE5 3
  • TGASEX 3
  • PSS2 3
  • TGM6 3

External Ids for TGM5 Gene

Previous GeneCards Identifiers for TGM5 Gene

  • GC15M038893
  • GC15M036421
  • GC15M041104
  • GC15M041241
  • GC15M041312
  • GC15M043527
  • GC15M020373

Summaries for TGM5 Gene

Entrez Gene Summary for TGM5 Gene

  • This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]

GeneCards Summary for TGM5 Gene

TGM5 (Transglutaminase 5) is a Protein Coding gene. Diseases associated with TGM5 include Peeling Skin Syndrome 2 and Peeling Skin Syndrome. GO annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM5 Gene

  • Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM5 Gene

Genomics for TGM5 Gene

Regulatory Elements for TGM5 Gene

Enhancers for TGM5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TGM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TGM5 Gene

43,232,595 bp from pter
43,267,023 bp from pter
34,429 bases
Minus strand

Genomic View for TGM5 Gene

Genes around TGM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM5 Gene

Proteins for TGM5 Gene

  • Protein details for TGM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • O43549
    • Q0VF40
    • Q9UEZ4

    Protein attributes for TGM5 Gene

    720 amino acids
    Molecular mass:
    80778 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TGM5 Gene


neXtProt entry for TGM5 Gene

Proteomics data for TGM5 Gene at MOPED

Selected DME Specific Peptides for TGM5 Gene

Post-translational modifications for TGM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM5 Gene

Antibody Products

Domains & Families for TGM5 Gene

Gene Families for TGM5 Gene

Suggested Antigen Peptide Sequences for TGM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the transglutaminase superfamily. Transglutaminase family.
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM5: view

Function for TGM5 Gene

Molecular function for TGM5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium in NHEK cells.

Enzyme Numbers (IUBMB) for TGM5 Gene

Gene Ontology (GO) - Molecular Function for TGM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity IEA --
genes like me logo Genes that share ontologies with TGM5: view
genes like me logo Genes that share phenotypes with TGM5: view

Human Phenotype Ontology for TGM5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TGM5 Gene

miRTarBase miRNAs that target TGM5

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TGM5 Gene

Localization for TGM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGM5 Gene

Cytoplasm. Note=Associated with intermediate filaments.

Subcellular locations from

Jensen Localization Image for TGM5 Gene COMPARTMENTS Subcellular localization image for TGM5 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TGM5 Gene

Pathways & Interactions for TGM5 Gene

SuperPathways for TGM5 Gene

No Data Available

Interacting Proteins for TGM5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000220420 for TGM5 Gene via STRING

Gene Ontology (GO) - Biological Process for TGM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9452468
GO:0008544 epidermis development TAS 9452468
genes like me logo Genes that share ontologies with TGM5: view

No data available for Pathways by source and SIGNOR curated interactions for TGM5 Gene

Drugs & Compounds for TGM5 Gene

(2) Drugs for TGM5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
calcium Nutra 0

(2) Additional Compounds for TGM5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
genes like me logo Genes that share compounds with TGM5: view

Transcripts for TGM5 Gene

mRNA/cDNA for TGM5 Gene

Unigene Clusters for TGM5 Gene

Transglutaminase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGM5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for TGM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGM5 Gene

mRNA expression in normal human tissues for TGM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGM5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x18.2), Skin - Not Sun Exposed (Suprapubic) (x15.8), and Esophagus - Mucosa (x5.1).

Protein differential expression in normal tissues from HIPED for TGM5 Gene

This gene is overexpressed in Liver (59.0) and Esophagus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TGM5 Gene

SOURCE GeneReport for Unigene cluster for TGM5 Gene Hs.129719

mRNA Expression by UniProt/SwissProt for TGM5 Gene

Tissue specificity: Expressed in foreskin keratinocytes.
genes like me logo Genes that share expression patterns with TGM5: view

Protein tissue co-expression partners for TGM5 Gene

Primer Products

Orthologs for TGM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TGM5 35
  • 87.81 (n)
  • 86.07 (a)
TGM5 36
  • 86 (a)
(Canis familiaris)
Mammalia TGM5 35
  • 87.18 (n)
  • 85.87 (a)
TGM5 36
  • 86 (a)
(Mus musculus)
Mammalia Tgm5 35
  • 83.89 (n)
  • 82.96 (a)
Tgm5 16
Tgm5 36
  • 82 (a)
(Pan troglodytes)
Mammalia TGM5 35
  • 99.26 (n)
  • 99.03 (a)
TGM5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC691932 35
  • 84.15 (n)
  • 84.06 (a)
(Monodelphis domestica)
Mammalia TGM5 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Gallus gallus)
Aves -- 36
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm5 35
  • 58.45 (n)
  • 53.1 (a)
(Danio rerio)
Actinopterygii tgm8 36
  • 38 (a)
Species with no ortholog for TGM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM5 Gene

Gene Tree for TGM5 (if available)
Gene Tree for TGM5 (if available)

Paralogs for TGM5 Gene

Paralogs for TGM5 Gene

(8) SIMAP similar genes for TGM5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGM5: view

Variants for TGM5 Gene

Sequence variations from dbSNP and Humsavar for TGM5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_013248 -
rs28756768 - 43,239,213(+) CATAT(C/G)CAGGG nc-transcript-variant, reference, missense
rs113463533 - 43,260,162(+) CCGCC(A/G)TGGGA intron-variant, nc-transcript-variant, reference, missense
rs112292549 Peeling skin syndrome 2 (PSS2) 43,260,151(+) CCGAC(A/C)CACGG intron-variant, nc-transcript-variant, reference, missense
rs7171797 - 43,235,673(+) CACCA(C/T)ATCAC nc-transcript-variant, downstream-variant-500B, reference, missense

Variation tolerance for TGM5 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.69; 86.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGM5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TGM5 Gene

Disorders for TGM5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TGM5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
peeling skin syndrome 2
  • peeling skin syndrome, acral type
peeling skin syndrome
  • peeling skin syndrome 1
  • cheiropompholyx
epidermolysis bullosa simplex
  • epidermolysis bullosa intraepidermic
- elite association - COSMIC cancer census association via MalaCards
Search TGM5 in MalaCards View complete list of genes associated with diseases


  • Peeling skin syndrome 2 (PSS2) [MIM:609796]: A non-inflammatory and localized form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In PSS2 patients, skin peeling is painless and strictly limited to the dorsa of the hands and feet. It is accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. {ECO:0000269 PubMed:16380904}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TGM5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TGM5: view

No data available for Genatlas for TGM5 Gene

Publications for TGM5 Gene

  1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PMID: 11390390) Grenard P. … Aeschlimann D. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Transglutaminase 5 is regulated by guanine-adenine nucleotides. (PMID: 15038793) Candi E. … Melino G. (Biochem. J. 2004) 23 25 26
  3. Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription- polymerase chain reaction with degenerate primers. (PMID: 9452468) Aeschlimann D. … Mosher D.F. (J. Biol. Chem. 1998) 2 3 23
  4. Inactive and highly active, proteolytically processed transglutaminase-5 in epithelial cells. (PMID: 18509357) Pietroni V. … Melino G. (J. Invest. Dermatol. 2008) 3 23
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for TGM5 Gene

Sources for TGM5 Gene