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TGM5 Gene

protein-coding   GIFtS: 54
GCID: GC15M043527

Transglutaminase 5

  See TGM5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transglutaminase 51 2     TGASE52
TGX2 3 5     TGASEX2
Transglutaminase X2 3     TGM62
TG(X)2 3     Protein-Glutamine Gamma-Glutamyltransferase 52
TGMX2 3     Transglutaminase V2
TGase-52 3     transglutaminase-52
TGase X2 3     Transglutaminase-53
EC 2.3.2.133 8     

External Ids:    HGNC: 117811   Entrez Gene: 93332   Ensembl: ENSG000001040557   OMIM: 6038055   UniProtKB: O435483   

Export aliases for TGM5 gene to outside databases

Previous GC identifers: GC15M038893 GC15M036421 GC15M041104 GC15M041241 GC15M041312 GC15M020373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGM5 Gene:
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein
cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This
reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
(provided by RefSeq, Oct 2009)

GeneCards Summary for TGM5 Gene:
TGM5 (transglutaminase 5) is a protein-coding gene. Diseases associated with TGM5 include peeling skin syndrome, and nor polyagglutination syndrome. GO annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM3.

UniProtKB/Swiss-Prot: TGM5_HUMAN, O43548
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to
the formation of the cornified cell envelope of keratinocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGM5 gene promoter:
         HOXA9   HOXA9B   FAC1   AML1a   HOXA5   Sox9   Meis-1a   Ik-3   Meis-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGM5 promoter sequence
   Search Chromatin IP Primers for TGM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15

TGM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043527:  view genomic region     (about GC identifiers)

Start:
43,524,793 bp from pter      End:
43,559,055 bp from pter
Size:
34,263 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TGM5_HUMAN, O43548 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase 5  
Size: 720 amino acids; 80778 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Secondary accessions: O43549 Q0VF40 Q9UEZ4
Alternative splicing: 2 isoforms:  O43548-1   O43548-2   

Explore the universe of human proteins at neXtProt for TGM5: NX_O43548

Explore proteomics data for TGM5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TGM5 (O43548)
     GFIYQGS  YGQCWVFA 


    See TGM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004236.1  NP_963925.2  

    ENSEMBL proteins: 
     ENSP00000220420   ENSP00000220419  

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    antibodies-online proteins for TGM5 (4 products) 

     
    antibodies-online peptides for TGM5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TGM: Transglutaminases

    Selected InterPro protein domains (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry O43548

    ProtoNet protein and cluster: O43548

    1 Blocks protein domain: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM5_HUMAN, O43548
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    Find genes that share domains with TGM5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGM5_HUMAN, O43548
    Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to
    the formation of the cornified cell envelope of keratinocytes
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium in NHEK cells

         Enzyme Number (IUBMB): EC 2.3.2.131 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003810protein-glutamine gamma-glutamyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TGM5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TGM5:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TGM5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGM5_HUMAN, O43548: Cytoplasm. Note=Associated with intermediate filaments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TGM5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TGM5
    Interactions:

        Search GeneGlobe Interaction Network for TGM5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TGM5 (ENSP000002204204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA1ENSP000003437014STRING: ENSP00000343701
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9452468
    GO:0008544epidermis development TAS9452468
    GO:0018149peptide cross-linking IEA--

    Find genes that share ontologies with TGM5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGM5

    3 HMDB Compounds for TGM5    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--

    1 DrugBank Compound for TGM5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate17139284 15038793 17016423

    2 Novoseek inferred chemical compound relationships for TGM5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 38.1 2 15290346 (2)
    calcium 0 1 9452468 (1)



    Find genes that share compounds with TGM5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TGM5 gene (2 alternative transcripts): 
    NM_004245.3  NM_201631.3  

    Unigene Cluster for TGM5:

    Transglutaminase 5
    Hs.129719  [show with all ESTs]
    Unigene Representative Sequence: NM_201631
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220420(uc001zrc.2 uc001zrd.2 uc001zre.2) ENST00000349114
    ENST00000396996 ENST00000563838
    miRNA
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    hsa-miR-19b hsa-miR-19a
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      QuantiFast Probe-based Assays in human, mouse, rat TGM5

    Additional mRNA sequence: 

    AF035960.1 AF035961.1 AK298479.1 BC119009.1 BC122859.1 

    4 DOTS entries:

    DT.75148954  DT.91722904  DT.100661857  DT.99927398 

    9 AceView cDNA sequences:

    CB243274 NM_201631 AF035960 AF035961 BE140571 NM_004245 BC039086 BI831326 
    AI834226 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TGM5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -                                                   
    SP2:                                -                                             


    ECgene alternative splicing isoforms for TGM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TGM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCCCAGT
    TGM5 Expression
    About this image


    TGM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)
             Spinous Keratinocytes Stratified Epidermis
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Kidney (Urinary System)
             Metanephros
     
     Testis (Reproductive System)
    TGM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129719

    UniProtKB/Swiss-Prot: TGM5_HUMAN, O43548
    Tissue specificity: Expressed in foreskin keratinocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TGM5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgm51 , 5 transglutaminase 51, 5 83.89(n)1
    82.96(a)1
      2 (60.37 cM)5
    741761  NM_028799.21  NP_083075.11 
     1210461115 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    many ↔ many
    2(94287866-94299074)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    many ↔ many
    GL343882.1(73354-82604)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tgm51 transglutaminase 5 58.45(n)
    53.1(a)
      100486682  XM_002935533.2  XP_002935579.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tgm86
    transglutaminase 8
    38(a)
    1 → many
    6(59700726-59704992) ENSDARG00000097651


    ENSEMBL Gene Tree for TGM5 (if available)
    TreeFam Gene Tree for TGM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TGM5 gene
    TGM32  F13A12  TGM12  EPB422  TGM72  TGM42  TGM22  TGM62  
    8 SIMAP similar genes for TGM5 using alignment to 2 protein entries:     TGM5_HUMAN (see all proteins):
    TGM6    TGM3    TGM7    TGM2    hTGP    TGM4
    F13A1    TGM1

    Find genes that share paralogs with TGM5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGM5 (see all 718)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122925491,2,,4
    C,FPeeling skin syndrome, acral type (APSS)4 pathogenic123618447(+) CCGACC/ACACGG 3 /G /C mis1 int12Minor allele frequency- A:0.00NA EU 5779
    rs1458964211,2
    --23590396(+) TCTACC/TTCATT 2 -- ds50010--------
    rs5138151,2
    C,F,H--23590518(+) TAGATG/ATCATA 2 -- ds500114Minor allele frequency- A:0.02EA NA NS 1224
    rs1870952351,2
    --23590532(+) GAAAGA/GATTCA 2 -- ds50010--------
    rs773863391,2
    C--23590775(+) TACCCA/CTACAC 2 -- ds50010--------
    rs1911787211,2
    --23590778(+) CCCTAC/TACTCA 2 -- ds50010--------
    rs71761831,2
    C,F,A--23591235(+) TATTTG/ATTGAG 2 -- ut311Minor allele frequency- A:0.19WA 118
    rs1387135491,2
    --23591273(+) GAGTAC/TAGGGG 2 -- ut310--------
    rs1488273791,2
    C--23591464(+) TCACAC/TGTCTG 2 -- ut310--------
    rs1158237711,2
    C,F--23591577(+) TGTCCA/GCTCTT 4 S syn12Minor allele frequency- G:0.00WA NA 4766

    HapMap Linkage Disequilibrium report for TGM5 (43524793 - 43559055 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TGM5: --
    Human Gene Mutation Database (HGMD): TGM5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TGM5
    DNA2.0 Custom Variant and Variant Library Synthesis for TGM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603805   
    OMIM disorders: 609796  
    UniProtKB/Swiss-Prot: TGM5_HUMAN, O43548
  • Peeling skin syndrome, acral type (APSS) [MIM:609796]: A non-inflammatory and localized form of peeling
    skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In
    APSS patients, skin peeling is painless and strictly limited to the dorsa of the hands and feet. It is
    accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis
    shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for TGM5:    
    About MalaCards
    peeling skin syndrome    nor polyagglutination syndrome    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia


    Find genes that share disorders with TGM5           About GenesLikeMe

    Genetic Association Database (GAD): TGM5
    Human Genome Epidemiology (HuGE) Navigator: TGM5 (1 document)

    Export disorders for TGM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGM5 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with TGM5)
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    1. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PubMed id 11390390)1, 2, 3, 9 Grenard P.... Aeschlimann D. (J. Biol. Chem. 2001)
    2. Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription- polymerase chain reaction with degenerate primers. (PubMed id 9452468)1, 2, 3, 9 Aeschlimann D.... Mosher D.F. (J. Biol. Chem. 1998)
    3. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. (PubMed id 16380904)1, 2, 9 Cassidy A.J....McLean W.H.I. (Am. J. Hum. Genet. 2005)
    4. Transglutaminase 5 is acetylated at the N-terminal end. (PubMed id 15290349)1, 2, 9 Rufini A.... Candi E. (Amino Acids 2004)
    5. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (PubMed id 19654303)1, 4 Broderick P....Houlston R.S. (Cancer Res. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of transglutaminase 5 in normal and pathologic human epidermis. (PubMed id 12230511)1, 9 Candi E....Melino G. (J. Invest. Dermatol. 2002)
    8. Overexpressed transglutaminase 5 triggers cell death. (PubMed id 15290346)1, 9 Cadot B....Candi E. (Amino Acids 2004)
    9. Inactive and highly active, proteolytically processed transglutaminase-5 in epithelial cells. (PubMed id 18509357)1, 9 Pietroni V....Melino G. (J. Invest. Dermatol. 2008)
    10. Transglutaminase 5 expression in human hair follicle. (PubMed id 16117804)1, 9 Thibaut S....Bernard B.A. (J. Invest. Dermatol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9333 HGNC: 11781 AceView: TGM5 Ensembl:ENSG00000104055 euGenes: HUgn9333
    ECgene: TGM5 H-InvDB: TGM5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGM5 gene:
    Search GeneIP for patents involving TGM5

    GeneCards and IP:
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