Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGM4 Gene

protein-coding   GIFtS: 59
GCID: GC03P044916

transglutaminase 4 (prostate)

 Explore 4 diseases affiliated with
TGM4 via our new
 Human Malady Compendium 
Biological research products
for TGM4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transglutaminase 4 (Prostate)1 2     EC 2.3.2.133 8
TGP1 2 3     Fibrinoligase3
Prostate Transglutaminase2 3     HTGP1
Prostate-Specific Transglutaminase2 3     Protein-Glutamine Gamma-Glutamyltransferase 42
Transglutaminase P2 3     Transglutaminase-43
TG(P)2 3     Fibrinoligase3
TGase-42 3     Transglutaminase-43
TGase P2 3     

External Ids:    HGNC: 117801   Entrez Gene: 70472   Ensembl: ENSG000001638107   OMIM: 6005855   UniProtKB: P492213   

Export aliases for TGM4 gene to outside databases

Previous GC identifers: GC03P043872 GC03P044096 GC03P044735 GC03P044876 GC03P044891 GC03P044893 GC03P044896


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221
Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the
conjugation of polyamines to specific proteins in the seminal tract

Gene Wiki entry for TGM4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGM4 gene promoter:
         Elk-1   AML1a   RREB-1   AP-2gamma   NF-kappaB   CREB   deltaCREB   NF-kappaB2   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.33   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p22-p21.33

TGM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P044916:  view genomic region     (about GC identifiers)

Start:
44,916,098 bp from pter      End:
44,956,482 bp from pter
Size:
40,385 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase 4  
Size: 684 amino acids; 77145 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: Q16707 Q96QN4

Explore the universe of human proteins at neXtProt for TGM4: NX_P49221

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49221

  • 3 DME Specific Peptides for TGM4 (P49221)
     WNFGQFE  YKYPEGS  WMKRPDLP 

    TGM4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003232.2  
    ENSEMBL proteins: 
     ENSP00000296125   ENSP00000403711  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TGM4 (Transglutaminase 4/TGM4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TGM4
    OriGene Protein Over-expression Lysate: TGM4
    OriGene Custom Protein Services for TGM4 
    GenScript Custom Purified and Recombinant Proteins Services for TGM4
    Novus Biologicals TGM4 Protein
    Novus Biologicals TGM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TGM4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    TGM4 for ontologies           About GeneDecksing



    TGM4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TGM4 (Transglutaminase 4/TGM4)
    OriGene Antibodies (see all 2): TGM4
    OriGene Custom Antibody Services for TGM4 
    GenScript Custom Superior Antibodies Services for TGM4
    Novus Biologicals TGM4 Antibodies
    Abcam antibodies for TGM4 
    Uscn Antibodies for TGM4
    Search ThermoFisher Antibodies for TGM4

    Assay Products for TGM4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TGM4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TGM4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TGM4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry P49221

    ProtoNet protein and cluster: P49221

    1 Blocks protein family: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221
    Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the
    conjugation of polyamines to specific proteins in the seminal tract
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

         Genatlas biochemistry entry for TGM4:
    transglutaminase,type IV,expressed in prostate,with an alternatively splice variant, involved in reproductive process
    and processed pseudogene in the promoter containing a cyclophilin A

    Enzyme Number (IUBMB): EC 2.3.2.131 2

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGM4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TGM4
    SwitchGear 3'UTR luciferase reporter plasmidTGM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGM4 (see all 7)
    OriGene shRNA RFP: TGM4
    OriGene siRNA: TGM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGM4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TGM4 (NM_003241)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGM4
    Search LifeMap BioReagents cell lines for TGM4

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003810protein-glutamine gamma-glutamyltransferase activity NAS7916568
    GO:0046872metal ion binding IEA--


    TGM4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TGM4:
     Lamellipodia cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGM4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TGM4 (P492213 ENSP000002961254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    IGHG1P018573, ENSP000003749904I2D: score=1 STRING: ENSP00000374990
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018149peptide cross-linking NAS--
    GO:0018184protein polyamination NAS--


    TGM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGM4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGM4

    2 HMDB Compounds for TGM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for TGM4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate17139284 849457 17016423 239698 1361314

    1 Novoseek chemical compound relationship for TGM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetraethyleneglycol dimethacrylate 96.5 24 17244021 (5), 9721214 (5), 18561295 (3), 10580145 (3) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TGM4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TGM4 gene: 
    NM_003241.3  

    Unigene Cluster for TGM4:

    Transglutaminase 4 (prostate)
    Hs.438265  [show with all ESTs]
    Unigene Representative Sequence: NM_003241
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490928(uc003coa.2) ENST00000296125(uc003cob.2 uc003coc.4)
    ENST00000471637 ENST00000422219 ENST00000495844 ENST00000459830

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGM4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TGM4
    SwitchGear 3'UTR luciferase reporter plasmidTGM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGM4 (see all 7)
    OriGene shRNA RFP: TGM4
    OriGene siRNA: TGM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM4
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TGM4 (NM_003241)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TGM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM4

    Additional cDNA sequence: 

    AK092657.1 AK125536.1 AK300523.1 AK312936.1 BC007003.1 L34840.1 U31905.1 U79008.1 
    Y09559.1 

    10 DOTS entries:

    DT.409715  DT.92426564  DT.95362563  DT.75190921  DT.91848053  DT.92416286  DT.120906575  DT.102828036 
    DT.120906555  DT.120906571 

    24/93 AceView cDNA sequences (see all 93):

    BX641824 BX504455 AI732835 AK092657 U79008 BX508971 CD616651 AI623108 
    BF002748 AA631018 AI682323 AA595411 AI810595 BX504433 Y09559 AI792321 
    BF589521 BX504470 BE646093 BF678058 BF589495 BX112004 BF674118 AI674586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTCAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TGM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGM4

    SOURCE GeneReport for Unigene cluster: Hs.438265

    UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221
    Tissue specificity: Prostate

        SABiosciences Custom PCR Arrays for TGM4
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TGM4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TGM4 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TGM41 transglutaminase 4 (prostate) 58.41(n)
    48.24(a)
      420706  NM_001006368.1  NP_001006368.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    47(a)
    45(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343224.1(70493-89226)
    GL343224.1(154465-172492)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73563 protein-glutamine gamma-glutamyltransferase 33(a)     --


    ENSEMBL Gene Tree for TGM4 (if available)
    TreeFam Gene Tree for TGM4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGM4 gene
    EPB422  TGM12  TGM52  TGM32  F13A12  TGM72  TGM22  TGM62  
    18/19 SIMAP similar genes for TGM4 using alignment to 6 protein entries:     TGM4_HUMAN (see all proteins) (see all similar genes):
    hTGP    EIF3G    NEK4    C1orf143    EEF1E1    TMX3
    UTY    IRF2    RRM2B    NCKAP1L    COMMD1    TGM1
    F13A1    TGM3    TGM7    TGM6    TGM5    TGM2

    TGM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/832 NCBI SNPs in TGM4 are shown (see all 832    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172303811,2
    C,F,--44914136(+) ATTGCC/TCATCC 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1909173081,2
    --44914219(+) GAAGAC/TAACAT 1 -- us2k10--------
    rs1826291051,2
    --44914247(+) AAGTTA/CCTGTG 1 -- us2k10--------
    rs1888977281,2
    --44914533(+) AAATAC/TTGGAA 1 -- us2k10--------
    rs1166369871,2
    F,--44914624(+) AAAGAC/GTGGGC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1925147901,2
    --44914693(+) GTAATA/CCCAGT 1 -- us2k10--------
    rs776441711,2
    F,--44914722(+) GGGGCG/AGATCC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1407891941,2
    --44914767(+) TGCAGG/TGATAT 1 -- us2k10--------
    rs1848687741,2
    --44914776(+) ATGCTC/TTCATT 1 -- us2k10--------
    rs1150781461,2
    --44914851(+) AACATC/TAGCCA 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for TGM4 (44916098 - 44956482 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TGM4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM4
    DNA2.0 Custom Variant and Variant Library Synthesis for TGM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TGM4 for disorders           About GeneDecksing

    OMIM gene information: 600585    OMIM disorders: --

    4 diseases for TGM4:    About MalaCards
    prostatitis    lip cancer    prostate cancer    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for TGM4:
    Lip cancer

    3 Novoseek disease relationships for TGM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 54.2 32 18983858 (4), 17552366 (4), 17244021 (3), 8645175 (2) (see all 7)
    tumors 0 1 17244021 (1)
    cancer 0 2 17552366 (2)


    Export disorders for TGM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGM4 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TGM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. (PubMed id 7916568)1, 2, 3, 9 Grant F.J.... O'Hara P.J. (1994)
    2. Tissue specific and androgen-regulated expression of human prostate- specific transglutaminase. (PubMed id 8645175)1, 2, 9 Dubbink H.J....Romijn J.C. (1996)
    3. Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization. (PubMed id 7665178)1, 3, 9 Gentile V....Baldini A. (1995)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer. (PubMed id 17552366)1, 9 Davies G....Jiang W.G. (2007)
    6. The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway. (PubMed id 18983858)1, 9 Jiang W.G....Mason M.D. (2009)
    7. The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization. (PubMed id 9721214)1, 9 Dubbink H.J....Romijn J.C. (1998)
    8. Differential alternative splicing of human transgluta minase 4 in benign prostate hyperplasia and prostate cancer. (PubMed id 20177144)1, 9 Cho S.Y....Kim I.G. (2010)
    9. Hominoid seminal protein evolution and ancestral mating behavior. (PubMed id 18561295)1, 9 Carnahan S.J. and Jensen-Seaman M.I. (2008)
    10. Retinoic acid and androgen receptors combine to achiev e tissue specific control of human prostatic transglutaminase expression: a nove l regulatory network with broader significance. (PubMed id 22362749)1 Rivera-Gonzalez G.C....Maitland N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7047 HGNC: 11780 AceView: TGM4 Ensembl:ENSG00000163810 euGenes: HUgn7047
    ECgene: TGM4 H-InvDB: TGM4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGM4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TGM4 gene:
    Search GeneIP for patents involving TGM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TGM4 (Transglutaminase 4/TGM4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for TGM4 (Transglutaminase 4/TGM4)  
     OriGene Antibodies for TGM4   OriGene shRNA RFP for TGM4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGM4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM4  
     OriGene Protein Over-expression Lysate for TGM4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TGM4   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TGM4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TGM4   OriGene Custom Protein Services for TGM4  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGM4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM4
     GenScript Custom Purified and Recombinant Proteins Services for TGM4 GenScript cDNA clones with any tag delivered in your preferred vector for TGM4
     GenScript Custom Assay Services for TGM4 GenScript Custom Superior Antibodies Services for TGM4
     GenScript Custom overexpressing Cell Line Services for TGM4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TGM4 promoter
     Search Chromatin IP Primers for TGM4
     RT2 qPCR Primer Assay in human, mouse / rat TGM4
     Search GNC Networks for TGM4
     SABiosciences Custom PCR Arrays for TGM4
     Search Tocris compounds for TGM4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TGM4 antibodies
     TGM4 proteins
     TGM4 lysates
     Antibodies for TGM4
     See all of Abcam's Antibodies, Kits and Proteins for TGM4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TGM4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TGM4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4
     SwitchGear 3'UTR luciferase reporter plasmids for TGM4
     SwitchGear Promoter luciferase reporter plasmids for TGM4
     Search ThermoFisher Antibodies for TGM4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TGM4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4