TGM4 Gene
protein-coding GIFtS: 59
GCID: GC03P044916
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transglutaminase 4 (prostate)
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Aliases for TGM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transglutaminase 4 (Prostate)1 2 | | EC 2.3.2.133 8 | | TGP1 2 3 | | Fibrinoligase3 | | Prostate Transglutaminase2 3 | | HTGP1 | | Prostate-Specific Transglutaminase2 3 | | Protein-Glutamine Gamma-Glutamyltransferase 42 | | Transglutaminase P2 3 | | Transglutaminase-43 | | TG(P)2 3 | | Fibrinoligase3 | | TGase-42 3 | | Transglutaminase-43 | | TGase P2 3 | | |
Export aliases for TGM4 gene to outside databasesPrevious GC identifers: GC03P043872 GC03P044096 GC03P044735 GC03P044876 GC03P044891 GC03P044893 GC03P044896 |
Summaries for TGM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and theconjugation of polyamines to specific proteins in the seminal tract Gene Wiki entry for TGM4
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Genomic Views for TGM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TGM4 gene promoter: Elk-1 AML1a RREB-1 AP-2gamma NF-kappaB CREB deltaCREB NF-kappaB2 ZIC2/Zic2 NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for TGM4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22-p21.33 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p22-p21.33TGM4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P044916: view genomic region
(about GC identifiers)
Start:
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44,916,098 bp from pter |
End:
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44,956,482 bp from pter |
Size:
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40,385 bases |
Orientation:
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plus strand |
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Proteins for TGM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221 (See
protein sequence)Recommended Name: Protein-glutamine gamma-glutamyltransferase 4 Size: 684 amino acids; 77145 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: Q16707 Q96QN4Explore the universe of human proteins at neXtProt for TGM4: NX_P49221
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49221 3 DME Specific Peptides for TGM4 (P49221)
TGM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003232.2 ENSEMBL proteins: ENSP00000296125 ENSP00000403711 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
TGM4 for ontologies About GeneDecksing
TGM4 Antibody Products: Assay Products for TGM4: |
Protein
Domains / Families for TGM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGM4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P49221ProtoNet protein and cluster: P49221 1 Blocks protein family: IPB002931 Transglutaminase-like domain
UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family |
Function for TGM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and theconjugation of polyamines to specific proteins in the seminal tractCatalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3) Genatlas biochemistry entry for TGM4:transglutaminase,type IV,expressed in prostate,with an alternatively splice variant, involved in reproductive processand processed pseudogene in the promoter containing a cyclophilin A Enzyme Number (IUBMB): EC 2.3.2.131 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGM4 (NM_003241) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity |
NAS | 7916568 | | GO:0046872 | metal ion binding |
IEA | -- |
TGM4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TGM4:
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Pathways & Interactions for TGM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGM4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for TGM4 (P492213 ENSP000002961254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018149 | peptide cross-linking |
NAS | -- | | GO:0018184 | protein polyamination |
NAS | -- |
TGM4 for ontologies About GeneDecksing
|
Drugs & Compounds for TGM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TGM4 for compounds About GeneDecksing
Browse Tocris compounds for TGM4
2 HMDB Compounds for TGM4 About this table
1 DrugBank Compound for TGM4 About this table
1 Novoseek chemical compound relationship for TGM4 gene About this table
Search CenterWatch for drugs/clinical trials and news about TGM4 
|
Transcripts for TGM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TGM4 gene: NM_003241.3 Unigene Cluster for TGM4: Transglutaminase 4 (prostate) Hs.438265 [show with all ESTs]Unigene Representative Sequence: NM_0032416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000490928(uc003coa.2) ENST00000296125(uc003cob.2 uc003coc.4) ENST00000471637 ENST00000422219 ENST00000495844 ENST00000459830
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGM4 (NM_003241) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4  |
Additional cDNA sequence: AK092657.1 AK125536.1 AK300523.1 AK312936.1 BC007003.1 L34840.1 U31905.1 U79008.1 Y09559.1 10 DOTS entries: DT.409715 DT.92426564 DT.95362563 DT.75190921 DT.91848053 DT.92416286 DT.120906575 DT.102828036 DT.120906555 DT.120906571 24/93 AceView cDNA sequences (see all 93): BX641824 BX504455 AI732835 AK092657 U79008 BX508971 CD616651 AI623108 BF002748 AA631018 AI682323 AA595411 AI810595 BX504433 Y09559 AI792321 BF589521 BX504470 BE646093 BF678058 BF589495 BX112004 BF674118 AI674586 GeneLoc Exon Structure
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Expression for TGM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGM4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCCTCAAAAA
About this image See TGM4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TGM4
SOURCE GeneReport for Unigene cluster: Hs.438265 UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Tissue specificity: Prostate SABiosciences Custom PCR Arrays for TGM4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TGM4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4 |
Orthologs for TGM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TGM4 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for TGM4 (if available) TreeFam Gene Tree for TGM4 (if available)  |
Paralogs for TGM4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TGM4 gene
- EPB422 TGM12 TGM52 TGM32 F13A12 TGM72 TGM22 TGM62
18/19 SIMAP similar genes for TGM4 using alignment to 6 protein entries: TGM4_HUMAN (see all proteins)
(see all similar genes):hTGP EIF3G NEK4 C1orf143 EEF1E1 TMX3 UTY IRF2 RRM2B NCKAP1L COMMD1 TGM1 F13A1 TGM3 TGM7 TGM6 TGM5 TGM2
TGM4 for paralogs About GeneDecksing
|
Genomic Variants for TGM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TGM4 (44916098 - 44956482 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TGM4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM4 |
|
Disorders
/ Diseases for TGM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGM4 for disorders About GeneDecksing
OMIM gene information: 600585
OMIM disorders: --
4 diseases for TGM4: About MalaCardsprostatitis lip cancer prostate cancer immunodeficiency 1 disease from the University of Copenhagen DISEASES database for TGM4:Lip cancer 3 Novoseek disease relationships for TGM4 gene About this table
Export disorders for TGM4 gene to outside databases
|
Publications for TGM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGM4 gene, integrated from 9 sources (see all 35): (articles sorted by number of sources associating them with TGM4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. (PubMed id 7916568)1, 2, 3, 9 Grant F.J.... O'Hara P.J. (1994)
- Tissue specific and androgen-regulated expression of human prostate- specific transglutaminase. (PubMed id 8645175)1, 2, 9 Dubbink H.J....Romijn J.C. (1996)
- Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization. (PubMed id 7665178)1, 3, 9 Gentile V....Baldini A. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer. (PubMed id 17552366)1, 9 Davies G....Jiang W.G. (2007)
- The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway. (PubMed id 18983858)1, 9 Jiang W.G....Mason M.D. (2009)
- The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization. (PubMed id 9721214)1, 9 Dubbink H.J....Romijn J.C. (1998)
- Differential alternative splicing of human transgluta minase 4 in benign prostate hyperplasia and prostate cancer. (PubMed id 20177144)1, 9 Cho S.Y....Kim I.G. (2010)
- Hominoid seminal protein evolution and ancestral mating behavior. (PubMed id 18561295)1, 9 Carnahan S.J. and Jensen-Seaman M.I. (2008)
- Retinoic acid and androgen receptors combine to achiev e tissue specific control of human prostatic transglutaminase expression: a nove l regulatory network with broader significance. (PubMed id 22362749)1 Rivera-Gonzalez G.C....Maitland N.J. (2012)
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External Searches for TGM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TGM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for TGM4 gene: Search GeneIP for patents involving TGM4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TGM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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variant library, vector shuttling | | OriGene Custom Antibody Services for TGM4 | | OriGene Custom Protein Services for TGM4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGM4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM4 |
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| | | Search Tocris compounds for TGM4 |
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 | | TGM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM4 |
|  |  |  | | | Search ThermoFisher Antibodies for TGM4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM4 |
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