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Aliases for TGM4 Gene

Aliases for TGM4 Gene

  • Transglutaminase 4 2 3
  • Prostate-Specific Transglutaminase 3 4
  • Transglutaminase 4 (Prostate) 2 3
  • Prostate Transglutaminase 3 4
  • Transglutaminase P 3 4
  • Transglutaminase-4 3 4
  • Fibrinoligase 3 4
  • EC 2.3.2.13 4 64
  • TGase P 3 4
  • TGase-4 3 4
  • TG(P) 3 4
  • TGP 3 4
  • Protein-Glutamine Gamma-Glutamyltransferase 4 3
  • HTGP 3

External Ids for TGM4 Gene

Summaries for TGM4 Gene

GeneCards Summary for TGM4 Gene

TGM4 (Transglutaminase 4) is a Protein Coding gene. Diseases associated with TGM4 include lip cancer and prostate cancer. GO annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM4 Gene

  • Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

Gene Wiki entry for TGM4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM4 Gene

Genomics for TGM4 Gene

Genomic Location for TGM4 Gene

Start:
44,874,606 bp from pter
End:
44,914,990 bp from pter
Size:
40,385 bases
Orientation:
Plus strand

Genomic View for TGM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM4 Gene

Proteins for TGM4 Gene

  • Protein details for TGM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49221-TGM4_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 4
    Protein Accession:
    P49221
    Secondary Accessions:
    • Q16707
    • Q96QN4

    Protein attributes for TGM4 Gene

    Size:
    684 amino acids
    Molecular mass:
    77145 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Homodimer.

neXtProt entry for TGM4 Gene

Proteomics data for TGM4 Gene at MOPED

Selected DME Specific Peptides for TGM4 Gene

Post-translational modifications for TGM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TGM4 Gene

Gene Families for TGM4 Gene

HGNC:
  • TGM :Transglutaminases

UniProtKB/Swiss-Prot:

TGM4_HUMAN
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.:
    • P49221
genes like me logo Genes that share domains with TGM4: view

Function for TGM4 Gene

Molecular function for TGM4 Gene

GENATLAS Biochemistry: transglutaminase,type IV,expressed in prostate,with an alternatively splice variant, involved in reproductive process and processed pseudogene in the promoter containing a cyclophilin A
UniProtKB/Swiss-Prot CatalyticActivity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

Enzyme Numbers (IUBMB) for TGM4 Gene

Gene Ontology (GO) - Molecular Function for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity NAS 7916568
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TGM4: view

Phenotypes for TGM4 Gene

MGI mutant phenotypes for TGM4:
inferred from 1 alleles
GenomeRNAi human phenotypes for TGM4:
genes like me logo Genes that share phenotypes with TGM4: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TGM4 Gene

Localization for TGM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM4 Gene COMPARTMENTS Subcellular localization image for TGM4 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20596668
GO:0005794 Golgi apparatus IDA 20569004
GO:0031012 extracellular matrix IDA 20596668
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TGM4: view

Pathways for TGM4 Gene

SuperPathways for TGM4 Gene

No Data Available

Interacting Proteins for TGM4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296125%0d%0a9606.ENSP00000392709%0d%0a
Selected Interacting proteins: ENSP00000296125 P49221-TGM4_HUMAN for TGM4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IEA --
GO:0042628 mating plug formation IEA --
genes like me logo Genes that share ontologies with TGM4: view

No data available for Pathways by source for TGM4 Gene

Compounds for TGM4 Gene

(2) HMDB Compounds for TGM4 Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for TGM4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate

(1) Novoseek inferred chemical compound relationships for TGM4 Gene

Compound -log(P) Hits PubMed IDs
tetraethyleneglycol dimethacrylate 96.5 17
genes like me logo Genes that share compounds with TGM4: view

Transcripts for TGM4 Gene

Unigene Clusters for TGM4 Gene

Transglutaminase 4 (prostate):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGM4 Gene

No ASD Table

Relevant External Links for TGM4 Gene

GeneLoc Exon Structure for
TGM4
ECgene alternative splicing isoforms for
TGM4

Expression for TGM4 Gene

mRNA expression in normal human tissues for TGM4 Gene

mRNA differential expression in normal tissues according to GTEx for TGM4 Gene

This gene is overexpressed in Prostate (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TGM4 Gene

SOURCE GeneReport for Unigene cluster for TGM4 Gene Hs.438265

mRNA Expression by UniProt/SwissProt for TGM4 Gene

P49221-TGM4_HUMAN
Tissue specificity: Prostate
genes like me logo Genes that share expressions with TGM4: view

Orthologs for TGM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TGM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGM4 36
  • 99.37 (n)
  • 98.39 (a)
TGM4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgm4 36
  • 67.66 (n)
  • 54.86 (a)
Tgm4 16
Tgm4 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGM4 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm4 36
  • 67.62 (n)
  • 55.77 (a)
chicken
(Gallus gallus)
Aves TGM4 36
  • 58.55 (n)
  • 48.83 (a)
TGM4 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm4 36
  • 54.12 (n)
  • 45.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tgm2l 37
  • 32 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009098 36
  • 48.48 (n)
  • 38.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tg 37
  • 29 (a)
OneToMany
CG7356 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
CSA.9818 37
  • 31 (a)
OneToMany
Species with no ortholog for TGM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM4 Gene

ENSEMBL:
Gene Tree for TGM4 (if available)
TreeFam:
Gene Tree for TGM4 (if available)

Paralogs for TGM4 Gene

Paralogs for TGM4 Gene

genes like me logo Genes that share paralogs with TGM4: view

Variants for TGM4 Gene

Sequence variations from dbSNP and Humsavar for TGM4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1007 -- 44,914,038(+) ACAGA(G/T)TCTCT utr-variant-3-prime
rs877827 -- 44,894,578(-) CGAAG(C/G)CATTG intron-variant
rs937833 -- 44,904,248(-) CATGG(C/T)ATGCA intron-variant
rs937835 -- 44,890,883(-) CTCCA(G/T)TGGTG intron-variant
rs937836 -- 44,890,816(-) CAAAC(A/C)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGM4 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV Gain 17160897
nsv3792 CNV Loss 18451855
esv2725215 CNV Deletion 23290073
nsv521765 CNV Loss 19592680

Relevant External Links for TGM4 Gene

HapMap Linkage Disequilibrium report
TGM4
Human Gene Mutation Database (HGMD)
TGM4

Disorders for TGM4 Gene

(2) MalaCards Diseases for TGM4 Gene

Search for TGM4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TGM4 Gene

(3) Novoseek inferred disease relationships for TGM4 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 54.2 17
tumors 0 1
cancer 0 2

Relevant External Links for TGM4

Genetic Association Database (GAD)
TGM4
genes like me logo Genes that share disorders with TGM4: view

No data available for UniProtKB/Swiss-Prot for TGM4 Gene

Publications for TGM4 Gene

  1. Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. (PMID: 7916568) Grant F.J. … O'Hara P.J. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. Tissue specific and androgen-regulated expression of human prostate- specific transglutaminase. (PMID: 8645175) Dubbink H.J. … Romijn J.C. (Biochem. J. 1996) 3 4 23
  3. Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization. (PMID: 7665178) Gentile V. … Baldini A. (Genomics 1995) 2 3 23
  4. The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization. (PMID: 9721214) Dubbink H.J. … Romijn J.C. (Genomics 1998) 3 23
  5. Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer. (PMID: 17552366) Davies G. … Jiang W.G. (J. Exp. Ther. Oncol. 2007) 3 23

Products for TGM4 Gene

Sources for TGM4 Gene

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