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Aliases for TGM4 Gene

Aliases for TGM4 Gene

  • Transglutaminase 4 2 3
  • Prostate-Specific Transglutaminase 3 4
  • Transglutaminase 4 (Prostate) 2 3
  • Prostate Transglutaminase 3 4
  • Transglutaminase P 3 4
  • Transglutaminase-4 3 4
  • Fibrinoligase 3 4
  • EC 2.3.2.13 4 63
  • TGase P 3 4
  • TGase-4 3 4
  • TG(P) 3 4
  • TGP 3 4
  • HTGP 3

External Ids for TGM4 Gene

Previous GeneCards Identifiers for TGM4 Gene

  • GC03P043872
  • GC03P044096
  • GC03P044735
  • GC03P044876
  • GC03P044891
  • GC03P044893
  • GC03P044896
  • GC03P044916

Summaries for TGM4 Gene

GeneCards Summary for TGM4 Gene

TGM4 (Transglutaminase 4) is a Protein Coding gene. Diseases associated with TGM4 include lip cancer. GO annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM4 Gene

  • Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

Gene Wiki entry for TGM4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM4 Gene

Genomics for TGM4 Gene

Genomic Location for TGM4 Gene

Chromosome:
3
Start:
44,874,592 bp from pter
End:
44,914,990 bp from pter
Size:
40,399 bases
Orientation:
Plus strand

Genomic View for TGM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM4 Gene

Proteins for TGM4 Gene

  • Protein details for TGM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49221-TGM4_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 4
    Protein Accession:
    P49221
    Secondary Accessions:
    • Q16707
    • Q96QN4

    Protein attributes for TGM4 Gene

    Size:
    684 amino acids
    Molecular mass:
    77145 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Homodimer.

neXtProt entry for TGM4 Gene

Proteomics data for TGM4 Gene at MOPED

Selected DME Specific Peptides for TGM4 Gene

Post-translational modifications for TGM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TGM4 (Transglutaminase 4/TGM4)

Domains & Families for TGM4 Gene

Gene Families for TGM4 Gene

Graphical View of Domain Structure for InterPro Entry

P49221

UniProtKB/Swiss-Prot:

TGM4_HUMAN :
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM4: view

Function for TGM4 Gene

Molecular function for TGM4 Gene

GENATLAS Biochemistry:
transglutaminase,type IV,expressed in prostate,with an alternatively splice variant, involved in reproductive process and processed pseudogene in the promoter containing a cyclophilin A
UniProtKB/Swiss-Prot CatalyticActivity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function:
Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

Enzyme Numbers (IUBMB) for TGM4 Gene

Gene Ontology (GO) - Molecular Function for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity NAS 7916568
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TGM4: view

Phenotypes for TGM4 Gene

genes like me logo Genes that share phenotypes with TGM4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGM4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TGM4 Gene

Localization for TGM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM4 Gene COMPARTMENTS Subcellular localization image for TGM4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20596668
GO:0005794 Golgi apparatus IDA 20569004
GO:0031012 extracellular matrix IDA 20596668
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TGM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TGM4 Gene

Pathways & Interactions for TGM4 Gene

SuperPathways for TGM4 Gene

No Data Available

Interacting Proteins for TGM4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296125%0d%0a9606.ENSP00000392709%0d%0a
Selected Interacting proteins: P49221-TGM4_HUMAN ENSP00000296125 for TGM4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TGM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IEA --
genes like me logo Genes that share ontologies with TGM4: view

No data available for Pathways by source and SIGNOR curated interactions for TGM4 Gene

Drugs & Compounds for TGM4 Gene

(2) Drugs for TGM4 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Calcium Nutra 0

(2) Additional Compounds for TGM4 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
TETRAETHYLENEGLYCOL DIMETHACRYLATE
genes like me logo Genes that share compounds with TGM4: view

Transcripts for TGM4 Gene

Unigene Clusters for TGM4 Gene

Transglutaminase 4 (prostate):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGM4 Gene

No ASD Table

Relevant External Links for TGM4 Gene

GeneLoc Exon Structure for
TGM4
ECgene alternative splicing isoforms for
TGM4

Expression for TGM4 Gene

mRNA expression in normal human tissues for TGM4 Gene

mRNA differential expression in normal tissues according to GTEx for TGM4 Gene

This gene is overexpressed in Prostate (x52.4).

Protein differential expression in normal tissues from HIPED for TGM4 Gene

This gene is overexpressed in Prostate (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TGM4 Gene



SOURCE GeneReport for Unigene cluster for TGM4 Gene Hs.438265

mRNA Expression by UniProt/SwissProt for TGM4 Gene

P49221-TGM4_HUMAN
Tissue specificity: Prostate
genes like me logo Genes that share expression patterns with TGM4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for TGM4 Gene

Orthologs for TGM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TGM4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tgm4 35
  • 67.66 (n)
  • 54.86 (a)
Tgm4 16
Tgm4 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TGM4 35
  • 99.37 (n)
  • 98.39 (a)
TGM4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm4 35
  • 67.62 (n)
  • 55.77 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TGM4 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TGM4 35
  • 58.55 (n)
  • 48.83 (a)
TGM4 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm4 35
  • 54.12 (n)
  • 45.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tgm2l 36
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7356 37
  • 33 (a)
Tg 36
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009098 35
  • 48.48 (n)
  • 38.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
CSA.9818 36
  • 31 (a)
OneToMany
Species with no ortholog for TGM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM4 Gene

ENSEMBL:
Gene Tree for TGM4 (if available)
TreeFam:
Gene Tree for TGM4 (if available)

Paralogs for TGM4 Gene

Paralogs for TGM4 Gene

genes like me logo Genes that share paralogs with TGM4: view

Variants for TGM4 Gene

Sequence variations from dbSNP and Humsavar for TGM4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2372832 -- 44,904,235(+) AAGGG(G/T)TCCCT intron-variant
rs4408902 -- 44,890,959(+) TGCCT(C/T)GCCCT intron-variant
rs4682759 -- 44,909,008(+) ttaac(A/G)acttc intron-variant
rs4683000 -- 44,879,265(+) tctct(A/C)tatat intron-variant
rs4683009 -- 44,909,403(+) tcctt(A/G)ttgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGM4 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV Gain 17160897
nsv3792 CNV Loss 18451855
esv2725215 CNV Deletion 23290073
nsv521765 CNV Loss 19592680

Variation tolerance for TGM4 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.49; 92.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGM4 Gene

HapMap Linkage Disequilibrium report
TGM4
Human Gene Mutation Database (HGMD)
TGM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM4 Gene

Disorders for TGM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TGM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lip cancer
  • malignant neoplasm of lower lip, buccal aspect
- elite association
Search TGM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TGM4

Genetic Association Database (GAD)
TGM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGM4
genes like me logo Genes that share disorders with TGM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGM4 Gene

Publications for TGM4 Gene

  1. Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization. (PMID: 7665178) Gentile V. … Baldini A. (Genomics 1995) 2 23 67
  2. Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. (PMID: 7916568) Grant F.J. … O'Hara P.J. (Biochem. Biophys. Res. Commun. 1994) 2 23 67
  3. Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer. (PMID: 20177144) Cho S.Y. … Kim I.G. (Exp. Mol. Med. 2010) 23 67
  4. The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway. (PMID: 18983858) Jiang W.G. … Mason M.D. (Microvasc. Res. 2009) 23 67
  5. Hominoid seminal protein evolution and ancestral mating behavior. (PMID: 18561295) Carnahan S.J. … Jensen-Seaman M.I. (Am. J. Primatol. 2008) 23 67

Products for TGM4 Gene

Sources for TGM4 Gene

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