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Aliases & Descriptions for TGM4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.3.2.13 3 | | FLJ26776 2 | | Fibrinoligase 3 | | TG(P) 3 | | TGP 1, 2, 3 | | TGase-4 3 | | Transglutaminase-4 3 | | hTGP 2 |
| | | Descriptions |
|---|
| Prostate transglutaminase 3 | | Prostate-specific transglutaminase 2, 3 | | transglutaminase 4 (prostate) 2 |
|
| | Search outside databases for aliases for TGM4 genePrevious GC identifers: GC03P043872 GC03P044096 GC03P044735 GC03P044876 GC03P044891 GC03P044893 |
Summaries for TGM4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tractGene Wiki entry for TGM4 |
Genomic Location for TGM4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TGM4 gene 
Entrez Gene cytogenetic band: 3p22-p21.33 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p22-p21.33TGM4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P044896:
(about GC identifiers)
Start:
|
44,888,721 bp from pter |
End:
|
44,931,092 bp from pter |
Size:
|
42,372 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for TGM4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221 (See
protein sequence)Recommended Name: Protein-glutamine gamma-glutamyltransferase 4 Size: 684 amino acids; 77145 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: Q16707 Q96QN4Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003232.2
ENSEMBL proteins: ENSP00000296125 ENSP00000379340
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TGM4 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for TGM4: Assays for TGM4: | Protein
Domains/ Families for TGM4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P49221
ProtoNet protein and cluster: P49221 1 Blocks protein family: IPB002931 Transglutaminase-like domain
UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family | Gene Function for TGM4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003241
Applied Biosystems Silencer® siRNAs for TGM4
Sigma-Aldrich siRNA and siRNA Panels for TGM4  Sigma-Aldrich shRNA for TGM4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003241                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003241                                  untagged cDNA clone in CMV expression vector: NM_003241 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003241
UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tractCatalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)Enzyme Number (IUBMB): EC 2.3.2.13 Genatlas biochemistry entry for TGM4:transglutaminase,type IV,expressed in prostate,with an alternatively splice variant, involved in reproductive process and processed pseudogene in the promoter containing a cyclophilin A4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TGM4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for TGM4 (Your Favorite Gene powered by Ingenuity) 
5/17 Interacting proteins for TGM4 (ENSP000002961253) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018149 | peptide cross-linking |
NAS | -- | | GO:0018184 | protein amino acid polyamination |
NAS | -- | About this table
|
Drugs & Compounds for TGM4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TGM4 1 Novoseek chemical compound relationship for TGM4 gene
About this table
|
Transcripts for TGM4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003241
Sigma-Aldrich siRNA and siRNA Panels for TGM4  Sigma-Aldrich shRNA for TGM4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003241 REFSEQ mRNAs for TGM4 gene: NM_003241.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003241               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003241                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003241                                  untagged cDNA clone in CMV expression vector: NM_003241  Additional cDNA sequence: AK092657.1 AK125536.1 AK300523.1 AK312936.1 BC007003.1 L34840.1 U31905.1 U79008.1 Y09559.1 11 DOTS entries: DT.409715 DT.92426564 DT.95362563 DT.91848053 DT.75190921 DT.92416286 DT.120906575 DT.75132045 DT.102828036 DT.120906555 DT.120906571 24/93 AceView cDNA sequences (see all 93
):AI732835 CD616651 BX508971 AI623108 BX504455 AA631018 BF002748 U79008 AK092657 BX641824 AI810595 Y09559 AA595411 BX504433 AI682323 BX504470 CD616658 NM_003241 BP333883 BU930676 BX641711 BX504466 BX504550 CD616656
highest scoring ESTs for TGM4:U31905 AA420692 AA564047 AA631018 AI418074 AI536125 AI623108 AI659889 AI668908 AI680052 Unigene Cluster for TGM4: Transglutaminase 4 (prostate) Hs.438265 [show with all ESTs]Unigene Representative Sequence: NM_003241
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000296125
ENST00000396022
|
Expression for TGM4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TGM4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TGM4
1 / 2 / 3 5 probe-sets matching TGM4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCTCAAAAA
SOURCE GeneReport for Unigene cluster: Hs.438265
Expression variation in blood from EXPOLDB for TGM4 UniProtKB/Swiss-Prot: TGM4_HUMAN, P49221Tissue specificity: Prostate |
Orthologs for TGM4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TGM4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TGM4
ENSEMBL Gene Tree for TGM4 | Paralogs for TGM4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TGM4 gene
- TGM32 F13A12 TGM12 TGM62
|
SNPs/Variants for TGM4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TGM4 (up to first 250kb)
|
Disorders & Mutations for TGM4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600585
3 Novoseek disease relationships for TGM4 gene
About this table
|
Medical News for TGM4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TGM4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for TGM4 gene (see all 23
):- Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. (PubMed id 7916568)1, 2, 3, 4 Grant F.J....O'Hara P.J. (1994)
- Tissue specific and androgen-regulated expression of human prostate- specific transglutaminase. (PubMed id 8645175)1, 3, 4 Dubbink H.J....Romijn J.C. (1996)
- Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization. (PubMed id 7665178)1, 2, 3 Gentile V....Baldini A. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer. (PubMed id 17552366)1, 3 Davies G....Jiang W.G. (2007)
- The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization. (PubMed id 9721214)1, 3 Dubbink H.J....Romijn J.C. (1998)
- Hominoid seminal protein evolution and ancestral mating behavior. (PubMed id 18561295)1, 3 Carnahan S.J. and Jensen-Seaman M.I. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. (PubMed id 7906657)3 Amendola A....Piacentini M. (1994)
|
Search for TGM4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TGM4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TGM4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGM4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TGM4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TGM4:

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Incremental update: 13 Oct 2009
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