Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TGM3 Gene

Aliases for TGM3 Gene

  • Transglutaminase 3 2 3
  • Transglutaminase E 3 4
  • Transglutaminase-3 3 4
  • EC 2.3.2.13 4 63
  • TGase E 3 4
  • TGase-3 3 4
  • TG(E) 3 4
  • TGE 3 4
  • Transglutaminase 3 (E Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase) 2
  • E Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase 3
  • Protein-Glutamine Gamma-Glutamyltransferase E 3
  • Protein-Glutamine-Gamma-Glutamyltransferase 2
  • E Polypeptide 2

External Ids for TGM3 Gene

Previous GeneCards Identifiers for TGM3 Gene

  • GC20P002264
  • GC20P002271
  • GC20P002224

Summaries for TGM3 Gene

Entrez Gene Summary for TGM3 Gene

  • Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGM3 Gene

TGM3 (Transglutaminase 3) is a Protein Coding gene. Diseases associated with TGM3 include neuroblastoma. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM3 Gene

  • Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

Gene Wiki entry for TGM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM3 Gene

Genomics for TGM3 Gene

Regulatory Elements for TGM3 Gene

Genomic Location for TGM3 Gene

Start:
2,295,967 bp from pter
End:
2,341,079 bp from pter
Size:
45,113 bases
Orientation:
Plus strand

Genomic View for TGM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM3 Gene

Proteins for TGM3 Gene

  • Protein details for TGM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08188-TGM3_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase E
    Protein Accession:
    Q08188
    Secondary Accessions:
    • A8K5N6
    • B2RCR6
    • D3DVX1
    • O95933
    • Q32ML9
    • Q32MM0

    Protein attributes for TGM3 Gene

    Size:
    693 amino acids
    Molecular mass:
    76632 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) cations per subunit. Binds 1 Ca(2+) as a zymogen, and binds 2 more Ca(2+) cations, or other divalent metal cations, after proteolytic processing.;
    Quaternary structure:
    • Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide.

    Three dimensional structures from OCA and Proteopedia for TGM3 Gene

neXtProt entry for TGM3 Gene

Proteomics data for TGM3 Gene at MOPED

Selected DME Specific Peptides for TGM3 Gene

Post-translational modifications for TGM3 Gene

  • Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TGM3 (Transglutaminase 3/TGM3)

Domains for TGM3 Gene

Gene Families for TGM3 Gene

HGNC:
  • TGM :Transglutaminases

Suggested Antigen Peptide Sequences for TGM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08188

UniProtKB/Swiss-Prot:

TGM3_HUMAN :
  • Q08188
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM3: view

Function for TGM3 Gene

Molecular function for TGM3 Gene

GENATLAS Biochemistry: transglutaminase,E polypeptide,cytoplasmic,soluble,type III (77kDa) (terminally differentiating epidermal and hair follicle keratinocytes)
UniProtKB/Swiss-Prot CatalyticActivity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

Enzyme Numbers (IUBMB) for TGM3 Gene

Gene Ontology (GO) - Molecular Function for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity IDA 12679341
GO:0003824 catalytic activity IDA 8099584
GO:0005509 calcium ion binding IDA 12679341
GO:0016746 transferase activity, transferring acyl groups TAS 15193648
genes like me logo Genes that share ontologies with TGM3: view

Phenotypes for TGM3 Gene

MGI mutant phenotypes for TGM3:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with TGM3: view

Animal Models for TGM3 Gene

MGI Knock Outs for TGM3:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TGM3 Gene

Localization for TGM3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM3 Gene COMPARTMENTS Subcellular localization image for TGM3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12850301
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 5038456
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TGM3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TGM3 Gene

Pathways for TGM3 Gene

SuperPathways for TGM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process NAS 8099584
GO:0018149 peptide cross-linking IDA 12679341
GO:0030216 keratinocyte differentiation TAS 24643
GO:0031069 hair follicle morphogenesis TAS 15193648
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with TGM3: view

No data available for Pathways by source for TGM3 Gene

Compounds for TGM3 Gene

(3) HMDB Compounds for TGM3 Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Calcium
  • Ca
7440-70-2
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9

(5) Drugbank Compounds for TGM3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5'-Guanosine-Diphosphate-Monothiophosphate
target
B-2-Octylglucoside
target
Guanosine-5'-Diphosphate
146-91-8 target
Guanosine-5'-Monophosphate
85-32-5 target
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate

(5) Novoseek inferred chemical compound relationships for TGM3 Gene

Compound -log(P) Hits PubMed IDs
triethylene glycol dimethacrylate 91.7 22
tgm 2 81.3 3
gtp 36.1 1
calcium 14.2 4
magnesium 4.56 1
genes like me logo Genes that share compounds with TGM3: view

Transcripts for TGM3 Gene

mRNA/cDNA for TGM3 Gene

(27) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGM3 Gene

Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGM3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TGM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGM3 Gene

No ASD Table

Relevant External Links for TGM3 Gene

GeneLoc Exon Structure for
TGM3
ECgene alternative splicing isoforms for
TGM3

Expression for TGM3 Gene

mRNA expression in normal human tissues for TGM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGM3 Gene

This gene is overexpressed in Esophagus - Mucosa (43.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TGM3 Gene

SOURCE GeneReport for Unigene cluster for TGM3 Gene Hs.2022

genes like me logo Genes that share expressions with TGM3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TGM3 Gene

Orthologs for TGM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGM3 35
  • 99.04 (n)
  • 98.12 (a)
TGM3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGM3 35
  • 82.99 (n)
  • 79.36 (a)
TGM3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGM3 35
  • 82.64 (n)
  • 78.35 (a)
TGM3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgm3 35
  • 80.23 (n)
  • 76.48 (a)
Tgm3 16
Tgm3 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGM3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGM3 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm3 35
  • 79.94 (n)
  • 76.19 (a)
chicken
(Gallus gallus)
Aves TGM3 35
  • 60.32 (n)
  • 56.66 (a)
TGM3 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm6 35
  • 51.81 (n)
  • 45.31 (a)
zebrafish
(Danio rerio)
Actinopterygii tgm8 36
  • 38 (a)
OneToMany
Species with no ortholog for TGM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM3 Gene

ENSEMBL:
Gene Tree for TGM3 (if available)
TreeFam:
Gene Tree for TGM3 (if available)

Paralogs for TGM3 Gene

Paralogs for TGM3 Gene

Selected SIMAP similar genes for TGM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGM3: view

Variants for TGM3 Gene

Sequence variations from dbSNP and Humsavar for TGM3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs84823 -- 2,320,662(-) GCGTG(A/C)CTCTT intron-variant
rs84824 -- 2,320,639(-) TGGCA(C/T)GAGCA intron-variant
rs84825 -- 2,319,962(+) GCCAG(C/T)TTAAA intron-variant
rs126635 -- 2,333,260(-) ATGCT(G/T)CTTTC intron-variant
rs214757 -- 2,294,164(-) GGCTC(C/T)TACCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TGM3 Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195
dgv1303e1 CNV Complex 17122850
essv4928 CNV CNV 17122850
nsv458850 CNV Gain 19166990
nsv9781 CNV Gain+Loss 18304495
nsv828671 CNV Gain 20364138
nsv817881 CNV Gain 17921354
esv34630 CNV Gain 17911159
nsv483148 CNV Gain 15286789

Relevant External Links for TGM3 Gene

HapMap Linkage Disequilibrium report
TGM3
Human Gene Mutation Database (HGMD)
TGM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM3 Gene

Disorders for TGM3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TGM3 Gene including...

Search for TGM3 Gene in MalaCards »

(7) Novoseek inferred disease relationships for TGM3 Gene

Disease -log(P) Hits PubMed IDs
dermatitis herpetiformis 79.4 2
skin diseases 45.3 1
carcinoma squamous cell 41.8 1
dermatitis atopic 38.8 2
psoriasis 35.3 2

Relevant External Links for TGM3

Genetic Association Database (GAD)
TGM3
Human Genome Epidemiology (HuGE) Navigator
TGM3
genes like me logo Genes that share disorders with TGM3: view

No data available for UniProtKB/Swiss-Prot for TGM3 Gene

Publications for TGM3 Gene

  1. The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. (PMID: 8099584) Kim I.-G. … Steinert P.M. (J. Biol. Chem. 1993) 3 4 23
  2. Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2. (PMID: 7851911) Wang M. … McBride O.W. (Genomics 1994) 2 3 23
  3. Structure and organization of the human transglutaminase 3 gene: evolutionary relationship to the transglutaminase family. (PMID: 7913719) Kim I.G. … Steinert P.M. (J. Invest. Dermatol. 1994) 3 23
  4. Crystal structure of transglutaminase 3 in complex with GMP: structural basis for nucleotide specificity. (PMID: 15084592) Ahvazi B. … Steinert P.M. (J. Biol. Chem. 2004) 3 23
  5. The emerging structural understanding of transglutaminase 3. (PMID: 15193648) Ahvazi B. … Rastinejad F. (J. Struct. Biol. 2004) 3 23

Products for TGM3 Gene

Sources for TGM3 Gene

Back to Top

Content