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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGM3 Gene

protein-coding   GIFtS: 55
GCID: GC20P002224

transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
 Explore 35 diseases affiliated with
TGM3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TGM3    

Aliases
for TGM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transglutaminase 3 (E Polypeptide,
Protein-Glutamine-Gamma-Glutamyltransferase)1 2
     TGase E2 3
TGE1 2 3     EC 2.3.2.133 8
Transglutaminase E2 3     Protein-Glutamine Gamma-Glutamyltransferase E2
TG(E)2 3     Transglutaminase-33
TGase-32 3     Transglutaminase-33

External Ids:    HGNC: 117791   Entrez Gene: 70532   Ensembl: ENSG000001257807   OMIM: 6002385   UniProtKB: Q081883   

Export aliases for TGM3 gene to outside databases

Previous GC identifers: GC20P002264 GC20P002271


Summaries
for TGM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TGM3:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide
bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence
at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two
polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later
stages of cell envelope formation in the epidermis and hair follicle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188
Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in
various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified
envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of
terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking
to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By
similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath

Gene Wiki entry for TGM3


Genomic Views
for TGM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGM3 gene promoter:
         SREBP-1c   C/EBPalpha   SREBP-1b   Max   SREBP-1a   c-Myb   Cart-1   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TGM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20q11.2

TGM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P002224:  view genomic region     (about GC identifiers)

Start:
 2,276,613 bp from pter      End:
 2,321,725 bp from pter
Size:
 45,113 bases      Orientation:
 plus strand

Proteins
for TGM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase E precursor  
Size: 693 amino acids; 76632 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide
6/8 PDB 3D structures from and Proteopedia for TGM3 (see all 8):
1L9M (3D)        1L9N (3D)        1NUD (3D)        1NUF (3D)        1NUG (3D)        1RLE (3D)    
Secondary accessions: A8K5N6 B2RCR6 D3DVX1 O95933 Q32ML9 Q32MM0

Explore the universe of human proteins at neXtProt for TGM3: NX_Q08188

Post-translational modifications:

  • Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral
    • bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between
    Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by
    CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08188

    • 4 DME Specific Peptides for TGM3 (Q08188)
     WNFGQFE  YKYPEGS  FIFAEVN  YGQCWVFA 

    TGM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003236.3  
    ENSEMBL proteins: 
     ENSP00000370867  

    Human Recombinant Protein Products: 
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    Uscn Proteins for TGM3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12850301
    GO:0031234extrinsic to internal side of plasma membrane IDA5038456


    TGM3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TGM3

    Protein Domains /
    Families
    for TGM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TGM3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry Q08188

    ProtoNet protein and cluster: Q08188

    1 Blocks protein family: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    Function
    for TGM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188
    Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in
    various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified
    envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of
    terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking
    to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By
    similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

         Genatlas biochemistry entry for TGM3:
    transglutaminase,E polypeptide,cytoplasmic,soluble,type III (77kDa) (terminally differentiating epidermal and hair
    follicle keratinocytes)

    Enzyme Number (IUBMB): EC 2.3.2.131 2

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TGM3:
    hsa-miR-4283 hsa-miR-1184 hsa-miR-19b hsa-miR-3143 hsa-miR-107 hsa-miR-19a hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: TGM3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14645372
    GO:0003810protein-glutamine gamma-glutamyltransferase activity IDA8099584
    GO:0003824catalytic activity IDA8099584
    GO:0003924GTPase activity IDA14645372
    GO:0005509calcium ion binding IDA14645372


    TGM3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tgm3tm1Sjo for TGM3
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Tgm3):
     integument 

    TGM3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TGM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/23 Interacting proteins for TGM3 (Q081883 ENSP000003708674) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG12O948173, ENSP000002744594I2D: score=1 STRING: ENSP00000274459
    CALML5Q9NZT13, ENSP000003696894I2D: score=1 STRING: ENSP00000369689
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    USP53Q70EK83, ENSP000002740304I2D: score=2 STRING: ENSP00000274030
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=3 STRING: ENSP00000229328
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA14645372
    GO:0006464cellular protein modification process NAS8099584
    GO:0018149peptide cross-linking IDA24643
    GO:0030216keratinocyte differentiation TAS24643
    GO:0031069hair follicle morphogenesis TAS15193648


    TGM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TGM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGM3

    3 HMDB Compounds for TGM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--

    5 DrugBank Compounds for TGM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate14508061 11093806 17139284 7733658 17016423
    B-2-Octylglucoside-- --target--17139284 17016423 10592235
    5'-Guanosine-Diphosphate-Monothiophosphate-- --target--17139284 17016423
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423
    Guanosine-5'-Monophosphate-- 85-32-5target--17139284 17016423

    5 Novoseek chemical compound relationships for TGM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triethylene glycol dimethacrylate 91.7 24 15335352 (5), 7913719 (5), 8626812 (4), 12874078 (2) (see all 10)
    tgm 2 81.3 3 7913719 (2), 7851911 (1)
    gtp 36.1 1 10518533 (1)
    calcium 14.2 5 14645372 (2), 11606197 (1), 9446578 (1)
    magnesium 4.56 1 14645372 (1)

    Search CenterWatch for drugs/clinical trials and news about TGM3 

    Transcripts
    for TGM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TGM3 gene: 
    NM_003245.3  

    Unigene Cluster for TGM3:

    Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
    Hs.2022  [show with all ESTs]
    Unigene Representative Sequence: NM_003245
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381458(uc002wfx.4) ENST00000463090

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    hsa-miR-4283 hsa-miR-1184 hsa-miR-19b hsa-miR-3143 hsa-miR-107 hsa-miR-19a hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: TGM3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK290324.1 AK291351.1 AK298637.1 AK299447.1 AK308249.1 AK315236.1 BC109075.1 BC109076.1 
    L10386.1 

    2 DOTS entries:

    DT.453020  DT.120834957 

    24/27 AceView cDNA sequences (see all 27):

    AL691671 BX284087 W16819 AI216028 BG675531 BE711006 L10386 AL602787 
    BV191283 BE710998 NM_003245 AW265587 AW361149 AW265479 N90882 BE714514 
    AW265475 BE711028 AW366274 BE710994 BE711030 N23065 BF089426 BM546690 

    GeneLoc Exon Structure


    Expression
    for TGM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCTCCGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TGM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGM3

    SOURCE GeneReport for Unigene cluster: Hs.2022
        SABiosciences Custom PCR Arrays for TGM3
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    In Situ
    Assay Products:     
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    Orthologs
    for TGM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TGM3 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TGM31 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) 60.31(n)
    57.04(a)    		   419215  XM_417392.3  XP_417392.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 5)    		 --
    		 52(a)
    51(a)
    (see all 5)    		 1 ↔ many
    1 ↔ many
    (see all 5)    		 GL343871.1(11077-31249)
    GL343882.1(106425-114940)
    zebrafish
    (Danio rerio)    		 Actinopterygii tgm5l6
    		 transglutaminase 5, like
    		 34(a)
    		 possible ortholog
    		 Zv9_scaffold3522(24531-41501)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tg6
    		 Transglutaminase
    		 28(a)
    		 possible ortholog
    		 2L(8011405-8026898)


    ENSEMBL Gene Tree for TGM3 (if available)
    TreeFam Gene Tree for TGM3 (if available) 

    Paralogs
    for TGM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGM3 gene
    F13A12  EPB422  TGM12  TGM52  TGM72  TGM42  TGM22  TGM62  
    8 SIMAP similar genes for TGM3 using alignment to 2 protein entries:     TGM3_HUMAN (see all proteins):
    TGM6    TGM5    TGM7    TGM1    TGM2    F13A1
    TGM4    EPB42

    TGM3 for paralogs           About GeneDecksing



    Genomic Variants
    for TGM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1110 NCBI SNPs in TGM3 are shown (see all 1110)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1477523791,2
    		--2274620(+) TGGCTC/TCCAGG 1 -- us2k10--------
    rs1500883051,2
    		--2274633(+) ACAGC-/AAA   
       AAAAA    AACAA     		1 -- us2k10--------
    rs2147571,2
    		C,F,A,H,--2274810(-) GGCTCT/CTACCA 1 -- us2k122Minor allele frequency- C:0.32NS EA NA WA CSA 969
    rs1406882621,2
    		--2274991(+) TAGGCA/GCTGAC 1 -- us2k10--------
    rs1887993571,2
    		--2275039(+) ACATAC/TGGGTA 1 -- us2k10--------
    rs1911000891,2
    		--2275040(+) CATATA/GGGTAT 1 -- us2k10--------
    rs1834617131,2
    		--2275088(+) CCCCCA/GTAAGA 1 -- us2k10--------
    rs1866305421,2
    		--2275090(+) CCCATA/TAGATG 1 -- us2k10--------
    rs1911356811,2
    		--2275225(+) TAAATC/TGGTAG 1 -- us2k10--------
    rs1500922701,2
    		--2275226(+) AAATCA/GGTAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TGM3 (2276613 - 2321725 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for TGM3
         6 CNVs: 9820 0222 8878 31030 4091 3205

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    Disorders / Diseases
    for TGM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TGM3 for disorders           About GeneDecksing

    OMIM gene information: 600238    OMIM disorders: --

    20/35 diseases for TGM3 (see all 35):    About MalaCards
    congenital ichthyosiform erythroderma    supranuclear palsy    dermatitis herpetiformis    progressive supranuclear palsy
    eczema herpeticum    squamous cell carcinoma    oral squamous cell carcinoma    netherton syndrome
    esophageal squamous cell carcinoma    differentiating neuroblastoma    dermatitis    gastroenteritis
    atopic dermatitis    skin disease    brain ischemia    leukoplakia
    celiac disease    ichthyosis    cholesteatoma    eczema

    7 Novoseek disease relationships for TGM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis herpetiformis 79.4 2 15649195 (1), 11901200 (1)
    skin diseases 45.3 1 16689864 (1)
    carcinoma squamous cell 41.8 1 16804985 (1)
    dermatitis atopic 38.8 4 15544612 (1), 16735375 (1)
    psoriasis 35.3 2 16689864 (1), 12230511 (1)
    hyperplasia 0.424 1 15975524 (1)
    tumors 0 3 12874078 (2)

    Human Genome Epidemiology (HuGE) Navigator: TGM3 (2 documents)

    Export disorders for TGM3 gene to outside databases

    Publications
    for TGM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGM3 gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with TGM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2. (PubMed id 7851911)1, 3, 9 Wang M....McBride O.W. (1994)
    2. The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. (PubMed id 8099584)1, 2, 9 Kim I.-G.... Steinert P.M. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription- polymerase chain reaction with degenerate primers. (PubMed id 9452468)1, 3 Aeschlimann D.... Mosher D.F. (1998)
    6. Structure and organization of the human transglutaminase 3 gene: evolutionary relationship to the transglutaminase family. (PubMed id 7913719)1, 9 Kim I.G....Steinert P.M. (1994)
    7. Characterization of Ets-binding sequence of human transglutaminase 3 gene promoter. (PubMed id 15335352)1, 9 Kim C.D....Lee J.H. (2004)
    8. Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail. (PubMed id 19005484)1, 9 Cheng T....Zeeuwen P.L. (2009)
    9. The human papillomavirus type 11 E1--E4 protein is a transglutaminase 3 substrate and induces abnormalities of the cornified cell envelope. (PubMed id 16257432)1, 9 Brown D.R....Ermel A. (2006)
    10. The proximal promoter of the human transglutaminase 3 gene. Stratified squamous epithelial-specific expression in cultured cells is mediated by binding of Sp1 and ets transcription factors to a proximal promoter element. (PubMed id 8626812)1, 9 Lee J.H....Steinert P.M. (1996)

    External Searches for TGM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TGM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7053 HGNC: 11779 AceView: TGM3 Ensembl:ENSG00000125780 euGenes: HUgn7053
    ECgene: TGM3 H-InvDB: TGM3

    Other Databases showing TGM3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TGM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGM3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgm3/

    Intellectual Property
    for TGM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TGM3 gene:
    Search GeneIP for patents involving TGM3

    Licensable Technologies for TGM3 gene:
    Weizmann Institute:Transglutaminase inhibitors for the treatment of neurodegenerative diseases
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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