Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TGM3 Gene

protein-coding   GIFtS: 59
GCID: GC20P002276

Transglutaminase 3

(Previous names: transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transglutaminase 31 2     E Polypeptide1
Transglutaminase E2 3     protein-glutamine-gamma-glutamyltransferase1
TG(E)2 3     Transglutaminase 3 (E Polypeptide,
Protein-Glutamine-Gamma-Glutamyltransferase)1
TGE2 3     E Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase2
TGase-32 3     Protein-Glutamine Gamma-Glutamyltransferase E2
TGase E2 3     transglutaminase-32
EC 2.3.2.133 8     Transglutaminase-33

External Ids:    HGNC: 117791   Entrez Gene: 70532   Ensembl: ENSG000001257807   OMIM: 6002385   UniProtKB: Q081883   

Export aliases for TGM3 gene to outside databases

Previous GC identifers: GC20P002264 GC20P002271 GC20P002224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TGM3 Gene:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine
isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino
acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene
consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein
is involved the later stages of cell envelope formation in the epidermis and hair follicle. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TGM3 Gene:
TGM3 (transglutaminase 3) is a protein-coding gene. GO annotations related to this gene include GTPase activity and calcium ion binding. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188
Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine
residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of
the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the
plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and
SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the
growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to
hardening the inner root sheath

Gene Wiki entry for TGM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGM3 gene promoter:
         SREBP-1c   C/EBPalpha   SREBP-1b   Max   SREBP-1a   c-Myb   Cart-1   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGM3 promoter sequence
   Search Chromatin IP Primers for TGM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20q11.2

TGM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P002276:  view genomic region     (about GC identifiers)

Start:
2,276,613 bp from pter      End:
2,321,725 bp from pter
Size:
45,113 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase E precursor  
Size: 693 amino acids; 76632 Da
Cofactor: Binds 3 calcium ions per subunit. Binds 1 calcium ion as a zymogen, and binds 2 more calcium ions, or
other divalent metal cations, after proteolytic processing
Subunit: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide
5 PDB 3D structures from and Proteopedia for TGM3:
1L9M (3D)        1L9N (3D)        1NUD (3D)        1NUF (3D)        1NUG (3D)    
Secondary accessions: A8K5N6 B2RCR6 D3DVX1 O95933 Q32ML9 Q32MM0

Explore the universe of human proteins at neXtProt for TGM3: NX_Q08188

Explore proteomics data for TGM3 at MOPED

Post-translational modifications: 

  • Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral
    bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or
    between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser
    extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for TGM3 (Q08188)
     WNFGQFE  YKYPEGS  FIFAEVN  YGQCWVFA 


    See TGM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003236.3  
    ENSEMBL proteins: 
     ENSP00000370867  

    TGM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TGM3 (Transglutaminase 3/TGM3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TGM3
    OriGene Protein Over-expression Lysate for TGM3
    OriGene MassSpec for TGM3
    OriGene Custom Protein Services for TGM3
    GenScript Custom Purified and Recombinant Proteins Services for TGM3
    Novus Biologicals TGM3 Lysate
    Sino Biological Recombinant Protein for TGM3
    Sino Biological Cell Lysate for TGM3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TGM3

     
    Search eBioscience for Proteins for TGM3 

     
    antibodies-online proteins for TGM3 (8 products) 

     
    antibodies-online peptides for TGM3

    TGM3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TGM3 (Transglutaminase 3/TGM3)
    OriGene Antibodies for TGM3
    OriGene Custom Antibody Services for TGM3
    Novus Biologicals TGM3 Antibodies
    Abcam antibodies for TGM3
    Cloud-Clone Corp. Antibodies for TGM3
    ThermoFisher Antibodies for TGM3
    antibodies-online antibodies for TGM3 

    TGM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TGM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TGM3
    Cloud-Clone Corp. CLIAs for TGM3
    Search eBioscience for ELISAs for TGM3 
    antibodies-online kits for TGM3 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TGM: Transglutaminases

    Selected InterPro protein domains (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry Q08188

    ProtoNet protein and cluster: Q08188

    1 Blocks protein domain: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM3_HUMAN, Q08188
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    Find genes that share domains with TGM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGM3_HUMAN, Q08188
    Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine
    residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of
    the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the
    plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and
    SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the
    growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to
    hardening the inner root sheath
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

         Genatlas biochemistry entry for TGM3:
    transglutaminase,E polypeptide,cytoplasmic,soluble,type III (77kDa) (terminally differentiating epidermal and hair
    follicle keratinocytes)

         Enzyme Number (IUBMB): EC 2.3.2.131 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ----
    GO:0003810protein-glutamine gamma-glutamyltransferase activity IDA12679341
    GO:0003824catalytic activity IDA8099584
    GO:0003924GTPase activity ----
    GO:0005509calcium ion binding IDA12679341
         
    Find genes that share ontologies with TGM3           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Tgm3):
     integument 

    Find genes that share phenotypes with TGM3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tgm3tm1Sjo for TGM3

       genOway: Develop your customized and physiologically relevant rodent model for TGM3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TGM3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TGM3:
    hsa-miR-4283 hsa-miR-1184 hsa-miR-19b hsa-miR-3143 hsa-miR-107 hsa-miR-19a hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTGM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TGM3
    Predesigned siRNA for gene silencing in human, mouse, rat TGM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGM3

    Clone
    Products:
         
    OriGene clones in human, mouse for TGM3 (see all 5)
    OriGene ORF clones in mouse, rat for TGM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TGM3 (NM_003245)
    Sino Biological Human cDNA Clone for TGM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TGM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12850301
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IDA5038456
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with TGM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TGM3
    Interactions:

        GeneGlobe Interaction Network for TGM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TGM3 (Q081883 ENSP000003708674) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG12O948173, ENSP000002744594I2D: score=1 STRING: ENSP00000274459
    CALML5Q9NZT13, ENSP000003696894I2D: score=1 STRING: ENSP00000369689
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    USP53Q70EK83, ENSP000002740304I2D: score=2 STRING: ENSP00000274030
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=3 STRING: ENSP00000229328
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006464cellular protein modification process NAS8099584
    GO:0018149peptide cross-linking IDA12679341
    GO:0030216keratinocyte differentiation TAS24643
    GO:0031069hair follicle morphogenesis TAS15193648

    Find genes that share ontologies with TGM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGM3

    3 HMDB Compounds for TGM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--

    5 DrugBank Compounds for TGM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate14508061 11093806 17139284 7733658 17016423
    B-2-Octylglucoside-- --target--17139284 17016423 10592235
    5'-Guanosine-Diphosphate-Monothiophosphate-- --target--17139284 17016423
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423
    Guanosine-5'-Monophosphate-- 85-32-5target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for TGM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triethylene glycol dimethacrylate 91.7 24 15335352 (5), 7913719 (5), 8626812 (4), 12874078 (2) (see all 10)
    tgm 2 81.3 3 7913719 (2), 7851911 (1)
    gtp 36.1 1 10518533 (1)
    calcium 14.2 5 14645372 (2), 11606197 (1), 9446578 (1)
    magnesium 4.56 1 14645372 (1)



    Find genes that share compounds with TGM3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TGM3 gene: 
    NM_003245.3  

    Unigene Cluster for TGM3:

    Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
    Hs.2022  [show with all ESTs]
    Unigene Representative Sequence: NM_003245
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381458(uc002wfx.4) ENST00000463090
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TGM3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TGM3:
    hsa-miR-4283 hsa-miR-1184 hsa-miR-19b hsa-miR-3143 hsa-miR-107 hsa-miR-19a hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTGM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TGM3
    Predesigned siRNA for gene silencing in human, mouse, rat TGM3
    Clone
    Products:
         
    OriGene clones in human, mouse for TGM3 (see all 5)
    OriGene ORF clones in mouse, rat for TGM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TGM3 (NM_003245)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TGM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGM3
      QuantiTect SYBR Green Assays in human, mouse, rat TGM3
      QuantiFast Probe-based Assays in human, mouse, rat TGM3

    Additional mRNA sequence: 

    AK290324.1 AK291351.1 AK298637.1 AK299447.1 AK308249.1 AK315236.1 BC109075.1 BC109076.1 
    L10386.1 

    2 DOTS entries:

    DT.453020  DT.120834957 

    Selected AceView cDNA sequences (see all 27):

    W16819 AL691671 BX284087 L10386 AL602787 NM_003245 BV191283 BG675531 
    BE711006 AI216028 AW265587 BE710998 AW265479 AW361149 AW366274 N90882 
    BE714514 AW265475 BE711028 N23065 BF089426 BM546690 BE710994 BE711030 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TGM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTCCGGG
    TGM3 Expression
    About this image


    TGM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis
             Stratified Epidermis
     
     Epithelial Cells
             Granular Keratinocytes Stratified Epidermis
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TGM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2022
        Custom PCR Arrays for TGM3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TGM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGM3
    QuantiTect SYBR Green Assays in human, mouse, rat TGM3
    QuantiFast Probe-based Assays in human, mouse, rat TGM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TGM3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgm31 , 5 transglutaminase 3, E polypeptide1, 5 80.23(n)1
    76.48(a)1
      2 (63.19 cM)5
    218181  NM_009374.31  NP_033400.21 
     1300123495 
    chicken
    (Gallus gallus)
    Aves TGM31 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) 60.32(n)
    56.66(a)
      419215  XM_417392.4  XP_417392.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    52(a)
    1 ↔ many
    1 ↔ many
    GL343871.1(11077-31389)
    GL343882.1(106425-114940)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tgm61 transglutaminase 6 51.81(n)
    45.31(a)
      100145475  NM_001126927.1  NP_001120399.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tgm86
    transglutaminase 8
    38(a)
    1 → many
    6(59700726-59704992) ENSDARG00000097651


    ENSEMBL Gene Tree for TGM3 (if available)
    TreeFam Gene Tree for TGM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TGM3 gene
    F13A12  TGM12  EPB422  TGM52  TGM72  TGM42  TGM22  TGM62  
    8 SIMAP similar genes for TGM3 using alignment to 2 protein entries:     TGM3_HUMAN (see all proteins):
    TGM6    TGM5    TGM7    TGM1    TGM2    F13A1
    TGM4    EPB42

    Find genes that share paralogs with TGM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TGM3 (see all 1349)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477523791,2
    --2274620(+) TGGCTC/TCCAGG 1 -- us2k10--------
    rs1500883051,2
    --2274633(+) ACAGC-/AAA   
       AAAAA
    AACAA
    1 -- us2k10--------
    rs2147571,2
    C,F,A,H--2274810(-) GGCTCT/CTACCA 1 -- us2k122Minor allele frequency- C:0.32NS EA NA WA CSA 969
    rs1406882621,2
    --2274991(+) TAGGCA/GCTGAC 1 -- us2k10--------
    rs1887993571,2
    --2275039(+) ACATAC/TGGGTA 1 -- us2k10--------
    rs1911000891,2
    --2275040(+) CATATA/GGGTAT 1 -- us2k10--------
    rs1834617131,2
    --2275088(+) CCCCCA/GTAAGA 1 -- us2k10--------
    rs1866305421,2
    --2275090(+) CCCATA/TAGATG 1 -- us2k10--------
    rs1911356811,2
    --2275225(+) TAAATC/TGGTAG 1 -- us2k10--------
    rs1500922701,2
    --2275226(+) AAATCA/GGTAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TGM3 (2276613 - 2321725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TGM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv817881CNV Gain17921354
    nsv458850CNV Gain19166990
    nsv483148CNV Gain15286789
    nsv470535CNV Gain18288195
    esv34630CNV Gain17911159
    nsv828671CNV Gain20364138
    nsv9781CNV Gain+Loss18304495
    essv4928CNV CNV17122850
    dgv1303e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TGM3
    DNA2.0 Custom Variant and Variant Library Synthesis for TGM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600238    OMIM disorders: --


    Find genes that share disorders with TGM3           About GenesLikeMe

    7 Novoseek inferred disease relationships for TGM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis herpetiformis 79.4 2 15649195 (1), 11901200 (1)
    skin diseases 45.3 1 16689864 (1)
    carcinoma squamous cell 41.8 1 16804985 (1)
    dermatitis atopic 38.8 4 15544612 (1), 16735375 (1)
    psoriasis 35.3 2 16689864 (1), 12230511 (1)
    hyperplasia 0.424 1 15975524 (1)
    tumors 0 3 12874078 (2)

    Genetic Association Database (GAD): TGM3
    Human Genome Epidemiology (HuGE) Navigator: TGM3 (2 documents)

    Export disorders for TGM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TGM3 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with TGM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2. (PubMed id 7851911)1, 3, 9 Wang M....McBride O.W. (Genomics 1994)
    2. The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. (PubMed id 8099584)1, 2, 9 Kim I.-G.... Steinert P.M. (J. Biol. Chem. 1993)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. FGFR2 is associated with hair thickness in Asian populations. (PubMed id 19590514)1, 4 Fujimoto A....Ohashi J. (J. Hum. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme. (PubMed id 12679341)1, 2 Ahvazi B....Steinert P.M. (J. Biol. Chem. 2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription- polymerase chain reaction with degenerate primers. (PubMed id 9452468)1, 3 Aeschlimann D.... Mosher D.F. (J. Biol. Chem. 1998)
    9. Structure and organization of the human transglutaminase 3 gene: evolutionary relationship to the transglutaminase family. (PubMed id 7913719)1, 9 Kim I.G....Steinert P.M. (J. Invest. Dermatol. 1994)
    10. Characterization of Ets-binding sequence of human transglutaminase 3 gene promoter. (PubMed id 15335352)1, 9 Kim C.D....Lee J.H. (Exp. Dermatol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7053 HGNC: 11779 AceView: TGM3 Ensembl:ENSG00000125780 euGenes: HUgn7053
    ECgene: TGM3 H-InvDB: TGM3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TGM3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgm3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TGM3 gene:
    Search GeneIP for patents involving TGM3

    Licensable Technologies for TGM3 gene:
    Weizmann Institute:Transglutaminase inhibitors for the treatment of neurodegenerative diseases
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TGM3 (Transglutaminase 3/TGM3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TGM3 (Transglutaminase 3/TGM3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TGM3   OriGene RNAi products in human, mouse, rat for TGM3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TGM3  
     OriGene MassSpec for TGM3   OriGene clones in human, mouse for TGM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TGM3   OriGene Purified Protein for TGM3  
     OriGene ORF clones in mouse, rat for TGM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TGM3   OriGene Custom Protein Services for TGM3  

     
     
     Block miRNA regulation of human, mouse, rat TGM3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TGM3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGM3 Predesigned siRNA for gene silencing in human, mouse, rat TGM3
     QuantiFast Probe-based Assays in human, mouse, rat TGM3 QuantiTect SYBR Green Assays in human, mouse, rat TGM3
     Custom PCR Arrays for TGM3 Search Chromatin IP Primers for TGM3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGM3  GeneGlobe Interaction Network for TGM3
     Regulatory tfbs in TGM3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TGM3 GenScript cDNA clones with any tag delivered in your preferred vector for TGM3
     GenScript Custom Assay Services for TGM3 GenScript Custom overexpressing Cell Line Services for TGM3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TGM3
     Proteins for TGM3
     Cell Lysates for TGM3
     cDNA Clones for TGM3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TGM3 antibodies
     TGM3 lysates
     Antibodies for TGM3
     See all of Abcam's Antibodies, Kits and Proteins for TGM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TGM3
     Antibodies for TGM3
     ELISAs for TGM3
     CLIAs for TGM3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TGM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM3
     SwitchGear 3'UTR luciferase reporter plasmids for TGM3
     SwitchGear Promoter luciferase reporter plasmids for TGM3
     ThermoFisher Antibodies for TGM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM3
     Browse compounds at ApexBio
     Search Addgene for plasmids for TGM3
      Search eBioscience for proteins for TGM3
      Search eBioscience for elisas for TGM3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TGM3
     antibodies-online antibodies for TGM3
     antibodies-online kits for TGM3 (12 products)
     antibodies-online peptides for TGM3
     antibodies-online proteins for TGM3 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TGM3 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4