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Aliases for TGM3 Gene

Aliases for TGM3 Gene

  • Transglutaminase 3 2 3 5
  • Transglutaminase E 3 4
  • Transglutaminase-3 3 4
  • EC 2.3.2.13 4 63
  • TGase E 3 4
  • TGase-3 3 4
  • TG(E) 3 4
  • TGE 3 4
  • Transglutaminase 3 (E Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase) 2
  • E Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase 3
  • Protein-Glutamine-Gamma-Glutamyltransferase 2
  • E Polypeptide 2

External Ids for TGM3 Gene

Previous GeneCards Identifiers for TGM3 Gene

  • GC20P002264
  • GC20P002271
  • GC20P002224

Summaries for TGM3 Gene

Entrez Gene Summary for TGM3 Gene

  • Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGM3 Gene

TGM3 (Transglutaminase 3) is a Protein Coding gene. Diseases associated with TGM3 include dermatitis herpetiformis and amyotrophic lateral sclerosis 11. GO annotations related to this gene include calcium ion binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is F13A1.

UniProtKB/Swiss-Prot for TGM3 Gene

  • Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

Gene Wiki entry for TGM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGM3 Gene

Genomics for TGM3 Gene

Regulatory Elements for TGM3 Gene

Genomic Location for TGM3 Gene

Chromosome:
20
Start:
2,295,967 bp from pter
End:
2,341,079 bp from pter
Size:
45,113 bases
Orientation:
Plus strand

Genomic View for TGM3 Gene

Genes around TGM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGM3 Gene

Proteins for TGM3 Gene

  • Protein details for TGM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08188-TGM3_HUMAN
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase E
    Protein Accession:
    Q08188
    Secondary Accessions:
    • A8K5N6
    • B2RCR6
    • D3DVX1
    • O95933
    • Q32ML9
    • Q32MM0

    Protein attributes for TGM3 Gene

    Size:
    693 amino acids
    Molecular mass:
    76632 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide.

    Three dimensional structures from OCA and Proteopedia for TGM3 Gene

neXtProt entry for TGM3 Gene

Proteomics data for TGM3 Gene at MOPED

Selected DME Specific Peptides for TGM3 Gene

Post-translational modifications for TGM3 Gene

  • Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TGM3 (Transglutaminase 3/TGM3)

Domains & Families for TGM3 Gene

Gene Families for TGM3 Gene

Suggested Antigen Peptide Sequences for TGM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08188

UniProtKB/Swiss-Prot:

TGM3_HUMAN :
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
Family:
  • Belongs to the transglutaminase superfamily. Transglutaminase family.
genes like me logo Genes that share domains with TGM3: view

Function for TGM3 Gene

Molecular function for TGM3 Gene

GENATLAS Biochemistry:
transglutaminase,E polypeptide,cytoplasmic,soluble,type III (77kDa) (terminally differentiating epidermal and hair follicle keratinocytes)
UniProtKB/Swiss-Prot CatalyticActivity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

Enzyme Numbers (IUBMB) for TGM3 Gene

Gene Ontology (GO) - Molecular Function for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003810 protein-glutamine gamma-glutamyltransferase activity IDA 8099584
genes like me logo Genes that share ontologies with TGM3: view
genes like me logo Genes that share phenotypes with TGM3: view

Animal Models for TGM3 Gene

MGI Knock Outs for TGM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TGM3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGM3 Gene

Localization for TGM3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGM3 Gene COMPARTMENTS Subcellular localization image for TGM3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12850301
genes like me logo Genes that share ontologies with TGM3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TGM3 Gene

Pathways & Interactions for TGM3 Gene

SuperPathways for TGM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TGM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030216 keratinocyte differentiation TAS 24643
GO:0051262 protein tetramerization IDA 5038456
genes like me logo Genes that share ontologies with TGM3: view

No data available for Pathways by source and SIGNOR curated interactions for TGM3 Gene

Drugs & Compounds for TGM3 Gene

(7) Drugs for TGM3 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Guanosine monophosphate Experimental Pharma Target 0
5'-Guanosine-Diphosphate-Monothiophosphate Experimental Pharma Target 0
B-2-Octylglucoside Experimental Pharma Target 0
Guanosine diphosphate Experimental Pharma Target 0

(4) Additional Compounds for TGM3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with TGM3: view

Transcripts for TGM3 Gene

mRNA/cDNA for TGM3 Gene

Unigene Clusters for TGM3 Gene

Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGM3 Gene

No ASD Table

Relevant External Links for TGM3 Gene

GeneLoc Exon Structure for
TGM3
ECgene alternative splicing isoforms for
TGM3

Expression for TGM3 Gene

mRNA expression in normal human tissues for TGM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGM3 Gene

This gene is overexpressed in Esophagus - Mucosa (x43.6).

Protein differential expression in normal tissues from HIPED for TGM3 Gene

This gene is overexpressed in Saliva (34.4) and Esophagus (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TGM3 Gene



SOURCE GeneReport for Unigene cluster for TGM3 Gene Hs.2022

genes like me logo Genes that share expression patterns with TGM3: view

Protein tissue co-expression partners for TGM3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TGM3 Gene

Orthologs for TGM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGM3 35
  • 99.04 (n)
  • 98.12 (a)
TGM3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGM3 36
  • 79 (a)
OneToOne
TGM3 35
  • 82.99 (n)
  • 79.36 (a)
dog
(Canis familiaris)
Mammalia TGM3 35
  • 82.64 (n)
  • 78.35 (a)
TGM3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgm3 36
  • 77 (a)
OneToOne
Tgm3 35
  • 80.23 (n)
  • 76.48 (a)
Tgm3 16
oppossum
(Monodelphis domestica)
Mammalia TGM3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGM3 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgm3 35
  • 79.94 (n)
  • 76.19 (a)
chicken
(Gallus gallus)
Aves TGM3 35
  • 60.32 (n)
  • 56.66 (a)
TGM3 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tgm6 35
  • 51.81 (n)
  • 45.31 (a)
zebrafish
(Danio rerio)
Actinopterygii tgm8 36
  • 38 (a)
OneToMany
Species with no ortholog for TGM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGM3 Gene

ENSEMBL:
Gene Tree for TGM3 (if available)
TreeFam:
Gene Tree for TGM3 (if available)

Paralogs for TGM3 Gene

Paralogs for TGM3 Gene

(8) SIMAP similar genes for TGM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGM3: view

Variants for TGM3 Gene

Sequence variations from dbSNP and Humsavar for TGM3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs214803 - 2,309,687(-) AGGCC(G/T)TCTGC reference, missense
rs6048066 - 2,311,076(+) GCATC(A/C/T)TCTTT reference, missense
rs214814 - 2,317,144(+) AAGGA(A/G)CTGGA reference, missense
rs1042617 - 2,335,158(+) TGAGA(A/G)GTACC reference, missense
rs214830 - 2,340,459(+) AGGAG(C/G/T)GGTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TGM3 Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195
dgv1303e1 CNV Complex 17122850
essv4928 CNV CNV 17122850
nsv458850 CNV Gain 19166990
nsv9781 CNV Gain+Loss 18304495
nsv828671 CNV Gain 20364138
nsv817881 CNV Gain 17921354
esv34630 CNV Gain 17911159
nsv483148 CNV Gain 15286789

Variation tolerance for TGM3 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGM3 Gene

HapMap Linkage Disequilibrium report
TGM3
Human Gene Mutation Database (HGMD)
TGM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGM3 Gene

Disorders for TGM3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TGM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dermatitis herpetiformis
  • dermatitis herpetiformis [dup]
amyotrophic lateral sclerosis 11
  • amyotrophic lateral sclerosis type 11
swine influenza
  • influenza due to influenza a virus subtype h1n1
gastroenteritis
  • cholera morbus
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TGM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TGM3

Genetic Association Database (GAD)
TGM3
Human Genome Epidemiology (HuGE) Navigator
TGM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGM3
genes like me logo Genes that share disorders with TGM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGM3 Gene

Publications for TGM3 Gene

  1. Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2. (PMID: 7851911) Wang M. … McBride O.W. (Genomics 1994) 2 3 23 67
  2. Transglutaminase-3, an esophageal cancer-related gene. (PMID: 11093806) Chen B.S. … Wu M. (Int. J. Cancer 2000) 23 25 26
  3. Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma. (PMID: 19522851) Negishi A. … Yamada T. (Cancer Sci. 2009) 3 23
  4. Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics. (PMID: 19142970) Uemura N. … Kondo T. (Int. J. Cancer 2009) 3 23
  5. Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail. (PMID: 19005484) Cheng T. … Zeeuwen P.L. (J. Invest. Dermatol. 2009) 3 23

Products for TGM3 Gene

Sources for TGM3 Gene

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