Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGM2 Gene

protein-coding   GIFtS: 73
GCID: GC20M036756

Transglutaminase 2

(Previous names: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transglutaminase 21 2     C Polypeptide1
protein-glutamine-gamma-glutamyltransferase1 2     Transglutaminase 2 (C Polypeptide,
Protein-Glutamine-Gamma-Glutamyltransferase)1
Tissue Transglutaminase2 3     G-ALPHA-h2
Transglutaminase C2 3     GNAH2
Transglutaminase H2 3     TG22
TG(C)2 3     TGase-H2
TGC2 3     C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase2
TGase-22 3     Protein-Glutamine Gamma-Glutamyltransferase 22
TGase C2 3     transglutaminase-22
TGase H2 3     Transglutaminase-23
EC 2.3.2.133 8     

External Ids:    HGNC: 117781   Entrez Gene: 70522   Ensembl: ENSG000001989597   OMIM: 1901965   UniProtKB: P219803   

Export aliases for TGM2 gene to outside databases

Previous GC identifers: GC20M036486 GC20M037395 GC20M037442 GC20M036190 GC20M033493


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGM2 Gene:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine
isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino
acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene
acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded
protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TGM2 Gene: 
TGM2 (transglutaminase 2) is a protein-coding gene. Diseases associated with TGM2 include nephrogenic systemic fibrosis, and focal myositis, and among its related super-pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and CREB Pathway. GO annotations related to this gene include GTP binding and protein-glutamine gamma-glutamyltransferase activity. An important paralog of this gene is TGM3.

UniProtKB/Swiss-Prot: TGM2_HUMAN, P21980
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

Gene Wiki entry for TGM2 (Tissue transglutaminase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGM2 gene promoter:
         COUP-TF1   STAT1   COUP-TF   COUP   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TGM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q12

TGM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGM2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M036756:  view genomic region     (about GC identifiers)

Start:
36,756,863 bp from pter      End:
36,794,980 bp from pter
Size:
38,118 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TGM2_HUMAN, P21980 (See protein sequence)
Recommended Name: Protein-glutamine gamma-glutamyltransferase 2  
Size: 687 amino acids; 77329 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Monomer
6/7 PDB 3D structures from and Proteopedia for TGM2 (see all 7):
1FAU (3D)        1KV3 (3D)        2Q3Z (3D)        3LY6 (3D)        3S3J (3D)        3S3P (3D)    
Secondary accessions: E1P5V9 Q16436 Q6B838 Q9BTN7 Q9UH35
Alternative splicing: 3 isoforms:  P21980-1   P21980-2   P21980-3   

Explore the universe of human proteins at neXtProt for TGM2: NX_P21980

Explore proteomics data for TGM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21980

  • 4/14 DME Specific Peptides for TGM2 (P21980) (see all 14)
     LVVRRGQ  WMTRPDL  WNFGQFE  GRWDNNY 

    TGM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TGM2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004604.2  NP_945189.1  

    ENSEMBL proteins: 
     ENSP00000355330   ENSP00000362502   ENSP00000387642   ENSP00000444701   ENSP00000437479  

    Human Recombinant Protein Products for TGM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TGM2 (Transglutaminase 2/TGM2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TGM2
    OriGene Protein Over-expression Lysate for TGM2
    OriGene MassSpec for TGM2 
    OriGene Custom Protein Services for TGM2
    GenScript Custom Purified and Recombinant Proteins Services for TGM2
    Novus Biologicals TGM2 Proteins
    Novus Biologicals TGM2 Lysates
    Sino Biological Recombinant Protein for TGM2
    Sino Biological Cell Lysate for TGM2 
    ProSpec Recombinant Protein for TGM2
    Cloud-Clone Corp. Proteins for TGM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane IEA--

    TGM2 for ontologies           About GeneDecksing



    TGM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TGM2
    R&D Systems Antibodies for TGM2 (Transglutaminase 2/TGM2)
    Cell Signaling Technology (CST) Antibodies for TGM2 
    OriGene Antibodies for TGM2
    OriGene Custom Antibody Services for TGM2
    GenScript Custom Superior Antibodies Services for TGM2
    Novus Biologicals TGM2 Antibodies
    Abcam antibodies for TGM2
    Cloud-Clone Corp. Antibodies for TGM2 
    ThermoFisher Antibody for TGM2
    LSBio Antibodies in human, mouse, rat for TGM2 

    Assay Products for TGM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TGM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TGM2 
    Cloud-Clone Corp. CLIAs for TGM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TGM: Transglutaminases

    5/7 InterPro protein domains (see all 7):
     IPR008958 Transglutaminase_C
     IPR014756 Ig_E-set
     IPR023608 Gln_gamma-glutamylTfrase_euk
     IPR001102 Transglutaminase_N
     IPR013808 Transglutaminase_CS

    Graphical View of Domain Structure for InterPro Entry P21980

    ProtoNet protein and cluster: P21980

    1 Blocks protein domain: IPB002931 Transglutaminase-like domain

    UniProtKB/Swiss-Prot: TGM2_HUMAN, P21980
    Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family


    TGM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGM2_HUMAN, P21980
    Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
    Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)
    Induction: By retinoic acid

         Genatlas biochemistry entry for TGM2:
    transglutaminase,C polypeptide,tissue,type II (80kDa),cytoplasmic,ubiquitous,interacting with huntingtin

         Enzyme Number (IUBMB): EC 2.3.2.131 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003810protein-glutamine gamma-glutamyltransferase activity ISS--
    GO:0005515protein binding IPI16301118
    GO:0005525GTP binding IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0046872metal ion binding IEA--
         
    TGM2 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tgm2):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 
     tumorigenesis 

    TGM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TGM2: Tgm2tm1.1Rmgr Tgm2tm1Gml Tgm2tm1Syki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TGM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TGM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGM2
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TGM2 (see all 15):
    hsa-miR-485-5p hsa-miR-4283 hsa-miR-3179 hsa-miR-1270 hsa-miR-19b hsa-miR-3154 hsa-miR-620 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTGM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TGM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGM2
    Sirion Biotech Customized adenovirus for overexpression of TGM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TGM2 (see all 13)
    OriGene ORF clones in mouse, rat for TGM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGM2 (NM_004613)
    Sino Biological Human cDNA Clone for TGM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM2
    Sirion Biotech Customized lentivirus for stable overexpression of TGM2 
                         Customized lentivirus expression plasmids for stable overexpression of TGM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGM2
    Search LifeMap BioReagents cell lines for TGM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TGM2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors0.64
    2CREB Pathway
    Activation of PKC through GPCR0.63
    3PTEN Pathway
    Phospholipase-C Pathway0.56
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.47
    5Thromboxane A2 receptor signaling
    Thromboxane A2 receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TGM2
        Development Activation of ERK by Alpha-1 adrenergic receptors

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TGM2
        Phospholipase-C Pathway
    Activation of PKC through GPCR

    1 Cell Signaling Technology (CST) Pathway for TGM2
        Ca, cAMP and Lipid Signaling

    1 GeneGo (Thomson Reuters) Pathway for TGM2
        Development Activation of ERK by Alpha-1 adrenergic receptors

    1 BioSystems Pathway for TGM2
        Thromboxane A2 receptor signaling



    1         Kegg Pathway  (Kegg details for TGM2):
        Huntington's disease


    TGM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/94 Interacting proteins for TGM2 (P219801, 2, 3 ENSP000003553304) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1P155312, 3, ENSP000000130344MINT-7219896 MINT-7219905 I2D: score=1 STRING: ENSP00000013034
    FN1P027511, 3, ENSP000003468394EBI-727668,EBI-1220319 I2D: score=3 STRING: ENSP00000346839
    SMAD2Q157962, 3, ENSP000002621604MINT-61627 I2D: score=3 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-61737 I2D: score=3 STRING: ENSP00000332973
    PAK1Q131532, 3, ENSP000002785684MINT-8272762 I2D: score=2 STRING: ENSP00000278568
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ----
    GO:0018149peptide cross-linking ----
    GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IEA--

    TGM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGM2

    3 HMDB Compounds for TGM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CalciumCa (see all 2)7440-70-2--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--

    2 DrugBank Compounds for TGM2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate16987813 17075129

    10/32 Novoseek inferred chemical compound relationships for TGM2 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgm 2 93.2 108 18235007 (12), 10334875 (8), 19763620 (7), 11742196 (5) (see all 16)
    gliadin 87.4 53 14747475 (4), 16377644 (3), 18376241 (3), 15290344 (2) (see all 29)
    gluten 86.5 50 17309775 (4), 12670536 (3), 16386476 (3), 15661929 (3) (see all 23)
    epsilon-(gamma-glutamyl)lysine 83.9 6 15715085 (1), 12528814 (1), 18235007 (1), 20192918 (1)
    cystamine 82.2 27 19632032 (5), 16181425 (2), 15715085 (1), 17669706 (1) (see all 11)
    glutamine 67.6 39 18761350 (2), 10334875 (1), 12205028 (1), 14747475 (1) (see all 22)
    gtp 56.5 39 19079660 (4), 17179049 (3), 16522628 (3), 15290346 (2) (see all 14)
    reticulin 51.5 6 12524400 (2), 9834257 (1), 15082580 (1)
    monodansylcadaverine 51.4 3 15069073 (1), 1680857 (1)
    lysine 45.8 18 14747475 (3), 18761350 (2), 18950638 (1), 17988081 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about TGM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TGM2 gene (2 alternative transcripts): 
    NM_004613.2  NM_198951.1  

    Unigene Cluster for TGM2:

    Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
    Hs.517033  [show with all ESTs]
    Unigene Representative Sequence: NM_004613
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469269(uc002xhq.3) ENST00000361475(uc002xhr.3 uc010zvx.2 uc010zvy.2 uc002xhs.1)
    ENST00000468262(uc002xht.3) ENST00000474777(uc002xhu.3) ENST00000373403
    ENST00000453095 ENST00000536701 ENST00000536724
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGM2
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TGM2 (see all 15):
    hsa-miR-485-5p hsa-miR-4283 hsa-miR-3179 hsa-miR-1270 hsa-miR-19b hsa-miR-3154 hsa-miR-620 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTGM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TGM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM2
    Clone
    Products:
         
    OriGene clones in human, mouse for TGM2 (see all 13)
    OriGene ORF clones in mouse, rat for TGM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGM2 (NM_004613)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM2
    Sirion Biotech Customized lentivirus for stable overexpression of TGM2 
                         Customized lentivirus expression plasmids for stable overexpression of TGM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TGM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TGM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM2

    Additional mRNA sequence: 

    AK058031.1 AK291714.1 AK295775.1 AK300292.1 AK314618.1 AY675221.1 BC003551.1 BC073946.1 
    M55153.1 M98478.1 M98479.1 S81734.1 

    24/61 DOTS entries (see all 61):

    DT.97864451  DT.87017520  DT.95284662  DT.120835528  DT.91711201  DT.100884909  DT.95205745  DT.100884877 
    DT.100884887  DT.100884889  DT.120835507  DT.40245747  DT.95088396  DT.100766727  DT.100884895  DT.92462870 
    DT.100884900  DT.120835482  DT.95088391  DT.120835725  DT.92462880  DT.120835494  DT.100840838  DT.120835608 

    24/999 AceView cDNA sequences (see all 999):

    CB143057 BQ654377 AA369090 CA438210 CR602180 AU135698 CB148727 AI249326 
    CB989196 AI888730 CB989149 CB139629 AL545063 BQ945467 BM542692 AI922220 
    BU628752 BQ928879 BM671914 BM760807 BQ938957 BQ438884 CR621392 AI192323 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for TGM2 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^
    SP1:                                      -                       -     -     -     -     -     -                       -                       -               
    SP2:                                      -                       -     -     -     -     -     -     -                 -                       -               
    SP3:                                      -                       -     -     -     -     -     -                       -                       -               
    SP4:                    -                 -                       -     -     -     -     -     -                       -                       -               
    SP5:                                      -                       -     -     -     -     -     -                       -                       -               

    ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
    SP1:              -                                   -     -                                 
    SP2:              -                                   -     -                                 
    SP3:              -                                                                           
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TGM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGM2 expression in normal human tissues (normalized intensities)      TGM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATTTTCT
    TGM2 Expression
    About this image


    TGM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Meckel's Cartilage
             sensory organ/nose/nasal septum   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
             huvec   
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Endothelium (Extraembryonic Tissues)    fully expand to see all 4 entries
             Human Villous Capillary Endothelial Cells (HVCEC)   
             huvec   

    See TGM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGM2

    SOURCE GeneReport for Unigene cluster: Hs.517033
        SABiosciences Expression via Pathway-Focused PCR Arrays including TGM2: 
              Autophagy in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TGM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TGM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TGM2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgm21 , 5 transglutaminase 2, C polypeptide1, 5 83.04(n)1
    84.26(a)1
      2 (78.72 cM)5
    218171  NM_009373.31  NP_033399.11 
     1581164025 
    chicken
    (Gallus gallus)
    Aves TGM21 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 69.39(n)
    64.82(a)
      396432  NM_205448.1  NP_990779.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    62(a)
    60(a)
    many → 1
    many → 1
    GL343413.1(3342-24215)
    GL343572.1(202498-264031)
    African clawed frog
    (Xenopus laevis)
    Amphibia tgm2-prov2 protein-glutamine gamma-glutamyltransferase 76.19(n)    BC056053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165242 Danio rerio protein-glutamine gamma-glutamyltransferase more 75.11(n)    AF242545.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73563 protein-glutamine
    gamma-glutamyltransferase
    34(a)     --


    ENSEMBL Gene Tree for TGM2 (if available)
    TreeFam Gene Tree for TGM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGM2 gene
    TGM32  F13A12  TGM12  EPB422  TGM52  TGM72  TGM42  TGM62  
    10 SIMAP similar genes for TGM2 using alignment to 7 protein entries:     TGM2_HUMAN (see all proteins):
    DKFZp667H046    TGM1    TGM7    hTGP    TGM3    TGM5
    TGM6    F13A1    EPB42    TGM4

    TGM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1084 SNPs in TGM2 are shown (see all 1084)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365544
    A colorectal cancer sample4--see VAR_0365542 G V mis40--------
    VAR_0379984
    ----see VAR_0379982 M R mis40--------
    VAR_0379994
    ----see VAR_0379992 I N mis40--------
    rs1815062261,2
    --36756375(+) GCCTCA/GAGGGC 1 -- ds50010--------
    rs785289161,2
    C,F--36756400(+) AGAAGG/CGGACA 1 -- ds50012Minor allele frequency- C:0.11CSA WA 120
    rs569777641,2
    C--36756514(+) AGAGGT/AGACTT 1 -- ds50013Minor allele frequency- A:0.18WA EA 240
    rs1152902991,2
    C,F--36756600(+) AACTAC/TATACA 1 -- ds50010--------
    rs1160881361,2
    F--36756661(+) GTTAAT/CTGTGG 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1507346421,2
    C--36756692(+) GGAAGA/GGGCCG 1 -- ds50010--------
    rs1458641631,2
    C--36756848(+) AGGAA-/CAGAC 
            
    CAGAC
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TGM2 (36756863 - 36794980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TGM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833972CNV Loss17160897
    esv29167CNV Gain19812545


    Human Gene Mutation Database (HGMD): TGM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TGM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TGM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190196    OMIM disorders: --

    20/79 diseases for TGM2 (see all 79):    About MalaCards
    nephrogenic systemic fibrosis    focal myositis    dermatitis herpetiformis    oculopharyngeal muscular dystrophy
    celiac disease    chorea-acanthocytosis    immunoglobulin alpha deficiency    acanthocytosis
    gastrointestinal system disease    irritable bowel syndrome    vascular dementia    chorea
    differentiating neuroblastoma    huntington's disease    pterygium    brain ischemia
    arthropathy    cervical intraepithelial neoplasia    ovarian cancer    urticaria

    3 diseases from the University of Copenhagen DISEASES database for TGM2:
    Celiac disease     Dermatitis herpetiformis     Huntington's disease

    TGM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/48 Novoseek inferred disease relationships for TGM2 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celiac disease 88.6 68 19680746 (3), 12670536 (2), 14747475 (2), 18092889 (2) (see all 47)
    dermatitis herpetiformis 65.1 4 12524400 (1), 15082580 (1), 14714018 (1)
    carcinoma pancreatic ductal 62.7 1 16951195 (1)
    huntington disease 57.3 10 18379433 (2), 17127346 (2), 20395409 (1), 18417122 (1) (see all 5)
    neurodegenerative diseases 48.8 19 17127346 (3), 18220838 (2), 19079660 (1), 18375543 (1) (see all 9)
    malabsorption 45.9 1 18286171 (1)
    myopathies idiopathic inflammatory 44.4 1 14631123 (1)
    autoimmune diseases 42.1 1 19892302 (1)
    atrophy 39.2 6 10556545 (1), 15082580 (1), 16293556 (1), 15181616 (1) (see all 5)
    pancreatic cancer 29.9 7 17374730 (4), 17507797 (2), 20224296 (1)

    Genetic Association Database (GAD): TGM2
    Human Genome Epidemiology (HuGE) Navigator: TGM2 (5 documents)

    Export disorders for TGM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGM2 gene, integrated from 9 sources (see all 488):
    (articles sorted by number of sources associating them with TGM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. (PubMed id 17939176)1, 2, 4, 9 Porzio O.... Barbetti F. (2007)
    2. Transglutaminase 2 undergoes a large conformational change upon activation. (PubMed id 18092889)1, 2, 9 Pinkas D.M.... Khosla C. (2007)
    3. The TGM2 gene is associated with schizophrenia in a British population. (PubMed id 18561261)1, 4, 9 Bradford M....Wei J. (2008)
    4. Germline mutations in TGM2 do not contribute to coeliac disease susceptibility in the Swedish population. (PubMed id 11742196)1, 4, 9 Popat S....Houlston R.S. (2001)
    5. A third human tissue transglutaminase homologue as a result of alternative gene transcripts. (PubMed id 8611626)1, 2, 9 Fraij B.M. and Gonzales R.A. (1996)
    6. The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization. (PubMed id 7912692)1, 3, 9 Gentile V....Baldini A. (1994)
    7. Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. (PubMed id 19182256)1, 4 Krumbiegel M....Reis A. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. (PubMed id 11390390)1, 3 Grenard P....Aeschlimann D. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7052 HGNC: 11778 AceView: TGM2 Ensembl:ENSG00000198959 euGenes: HUgn7052
    ECgene: TGM2 Kegg: 7052 H-InvDB: TGM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGM2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Tissue_transglutaminase
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgm2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TGM2 gene:
    Search GeneIP for patents involving TGM2

    Licensable Technologies for TGM2 gene:
    Weizmann Institute:Transglutaminase inhibitors for the treatment of neurodegenerative diseases
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TGM2
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TGM2 (Transglutaminase 2/TGM2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for TGM2 (Transglutaminase 2/TGM2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TGM2   OriGene RNAi products in human, mouse, rat for TGM2  
     OriGene qPCR primer pairs and template standards for TGM2   OriGene Protein Over-expression Lysate for TGM2  
     OriGene MassSpec something-or-other for TGM2   OriGene clones in human, mouse for TGM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TGM2   OriGene Purified Protein for TGM2  
     OriGene ORF clones in mouse, rat for TGM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TGM2   OriGene Custom Protein Services for TGM2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGM2
     QIAGEN SeqTarget long-range PCR primers for resequencing TGM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM2
     GenScript Custom Purified and Recombinant Proteins Services for TGM2 GenScript cDNA clones with any tag delivered in your preferred vector for TGM2
     GenScript Custom Assay Services for TGM2 GenScript Custom Superior Antibodies Services for TGM2
     GenScript Custom overexpressing Cell Line Services for TGM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for TGM2 

     Regulatory tfbs in TGM2 promoter
     Search Chromatin IP Primers for TGM2
     RT2 qPCR Primer Assay in human, mouse, rat TGM2
     GNC Network for TGM2
     SABiosciences PCR Arrays including human, mouse, rat TGM2
     Search Tocris compounds for TGM2
     Proteins and Antibodies for TGM2
     Cell Lysates for TGM2
     cDNA Clones for TGM2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TGM2 antibodies
     TGM2 proteins
     TGM2 lysates
     Antibodies for TGM2
     See all of Abcam's Antibodies, Kits and Proteins for TGM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TGM2




     Proteins for TGM2
     Antibodies for TGM2
     ELISAs for TGM2
     CLIAs for TGM2
     Search LifeMap BioReagents cell lines for TGM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM2
     SwitchGear 3'UTR luciferase reporter plasmids for TGM2
     SwitchGear Promoter luciferase reporter plasmids for TGM2
     ThermoFisher Antibody for TGM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TGM2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TGM2
    Customized:
     lentivirus for stable overexpression of TGM2
     lentivirus expression plasmids for stable overexpression of TGM2
     adenovirus for overexpression of TGM2
     LSBio Antibodies in human, mouse, rat for TGM2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TGM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4