TGM1 Gene
protein-coding GIFtS: 60
GCID: GC14M024718
|
|
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
(Previous symbol: ICR2)
| |
Aliases
for TGM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transglutaminase 1 (K Polypeptide Epidermal Type I,Protein-Glutamine-Gamma-Glutamyltransferase)1 2 | | TGase-12 3 | | TGK1 2 3 | | TGase K2 3 | | ICR21 2 5 | | EC 2.3.2.133 8 | | LI11 2 5 | | ARCI12 | | LI1 2 | | Protein-Glutamine Gamma-Glutamyltransferase K2 | | TGASE1 2 | | Transglutaminase 1 Isoform2 | | Epidermal TGase2 3 | | Transglutaminase, Keratinocyte2 | | Transglutaminase K2 3 | | Transglutaminase-13 | | KTG2 3 | | Transglutaminase-13 | | TG(K)2 3 | | |
Export aliases for TGM1 gene to outside databasesPrevious GC identifers: GC14M022090 GC14M018505 GC14M022708 GC14M023788 GC14M004833 |
Summaries
for TGM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TGM1:
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamineto a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads tocrosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis(LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TGM1_HUMAN, P22735Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible forcross-linking epidermal proteins during formation of the stratum corneum
Gene Wiki entry for TGM1 (Keratinocyte transglutaminase)
|
Genomic Views
for TGM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGM1 gene promoter:
Pax-5 Sp1 CUTL1 NF-kappaB IRF-2 STAT3 NF-kappaB1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2TGM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024718: view genomic region
(about GC identifiers)
Start:
|
24,718,320 bp from pter |
End:
|
24,733,638 bp from pter |
Size:
|
15,319 bases |
Orientation:
|
minus strand |
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Proteins
for TGM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TGM1_HUMAN, P22735 (See
protein sequence)Recommended Name: Protein-glutamine gamma-glutamyltransferase K Size: 817 amino acids; 89787 Da
Cofactor: Binds 1 calcium ion per subunit
Subcellular location: Membrane; Lipid-anchor
Sequence caution: Sequence=AAA61166.1; Type=Frameshift; Positions=16; Sequence=M86360; Type=Frameshift; Positions=16,421, 651;
1 PDB 3D structure from  and Proteopedia  for TGM1:2XZZ (3D)
Secondary accessions: Q197M4Explore the universe of human proteins at neXtProt for TGM1: NX_P22735
Post-translational modifications:
The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may becomethioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis,which releases the enzyme in a soluble form1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P22735
4/13 DME Specific Peptides for TGM1 (P22735) (see all 13)
TGM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000350.1
ENSEMBL proteins: ENSP00000206765 ENSP00000439446 ENSP00000453701 ENSP00000453337 ENSP00000453840 ENSP00000452822 ENSP00000453234 ENSP00000454070 ENSP00000452690
Human Recombinant Protein Products for TGM1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TGM1 for ontologies About GeneDecksing
TGM1 Antibody Products:
Assay Products for TGM1: |
Protein
Domains /
Families
for TGM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGM1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P22735ProtoNet protein and cluster: P22735 1 Blocks protein family: IPB002931 Transglutaminase-like domain
UniProtKB/Swiss-Prot: TGM1_HUMAN, P22735Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family |
Function
for TGM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TGM1_HUMAN, P22735Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible forcross-linking epidermal proteins during formation of the stratum corneumCatalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3) Genatlas biochemistry entry for TGM1:keratinocyte transglutaminase,K polypeptide,epidermal,type I (92kDa),membrane associated,crosslinking the structuralcomponents SPRRs,IVL and LOR for the formation of cornified enveloppe,also binding omega-hydroxyceramides to evolucrinby ester bond formation in the terminal step of the differentiation programme of epidermal keratinocytes
Enzyme Number (IUBMB): EC 2.3.2.131 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TGM1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TGM1:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tgm1):
TGM1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tgm1tm1Kfyn for TGM1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGM1 (NM_000359) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM1 |
|
Pathways & Interactions
for TGM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/12 Interacting proteins for TGM1 (P227353 ENSP000002067654) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TGM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TGM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TGM1 for compounds About GeneDecksing
 Browse Tocris compounds for TGM1
3 HMDB Compounds for TGM1 About this table
1 DrugBank Compound for TGM1 About this table
10/22 Novoseek chemical compound relationships for TGM1 gene (see all 22) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| collodion |
83.4 |
22 |
19500103 (3), 18948357 (2), 12542526 (2), 20021785 (1) (see all 8) |
| epsilon-(gamma-glutamyl)lysine |
72.7 |
1 |
1356818 (1) |
| cholesterol-sulfate |
68.1 |
8 |
9856823 (4), 9865910 (1), 17468528 (1), 10644724 (1) |
| 1,25 dihydroxy vitamin d3 |
49.6 |
1 |
8996256 (1) |
| monodansylcadaverine |
49.2 |
2 |
16639001 (1) |
| retinoic acid |
44.1 |
11 |
1355099 (4), 17147502 (2), 9196026 (1), 9989277 (1) (see all 5) |
| retinoid |
42.9 |
3 |
10871075 (2) |
| calcipotriol |
35.6 |
1 |
8996256 (1) |
| phorbol |
30.6 |
1 |
9361026 (1) |
| glutamine |
24.6 |
1 |
10644724 (1) |
Search CenterWatch for drugs/clinical trials and news about TGM1
|
Transcripts
for TGM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGM1 gene: NM_000359.2 Unigene Cluster for TGM1: Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) Hs.508950 [show with all ESTs]Unigene Representative Sequence: NM_0003599 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000206765(uc001wod.3 uc010tog.2) ENST00000544573 ENST00000559669
ENST00000559136(uc021rrn.1) ENST00000558074 ENST00000560443 ENST00000560478
ENST00000560226 ENST00000561067
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TGM1 (NM_000359) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM1 |
Additional cDNA sequence: AK291350.1 AK299436.1 AK301652.1 AK315819.1 AK315828.1 AK315843.1 BC034699.1 D90287.1 JF419518.1 M55183.1 M62925.1 X57974.1 7 DOTS entries: DT.309165 DT.120732257 DT.92421710 DT.100016111 DT.100732232 DT.120732253 DT.92421712 24/40 AceView cDNA sequences (see all 40): BX397642 D90287 BX439627 NM_000359 CA503076 CB241208 X57974 AL603353 BC034699 M55183 AI269864 BM083664 BI259332 BX408713 CN479042 CB852067 BX408714 CB266185 AW083702 M62925 BP372709 AL039214 BP359636 BV199783
GeneLoc Exon Structure
|
Expression
for TGM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TGM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGM1
SOURCE GeneReport for Unigene cluster: Hs.508950
SABiosciences Custom PCR Arrays for TGM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM1 |
Orthologs
for TGM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TGM1 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TGM16 |
-- |
67(a) |
1 ↔ 1 |
GL343400.1(152515-158859) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.112732 |
Transcribed sequence with weak similarity to protein more |
76.17(n) |
|
BG308040.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG73563
Tg1 |
protein-glutamine gamma-glutamyltransferase3
Transglutaminase1 |
37(a)3
49.85(n)1
38.74(a)1 |
|
340931 NM_135330.11 NP_609174.11 |
ENSEMBL Gene Tree for TGM1 (if available)
TreeFam Gene Tree for TGM1 (if available) |
Paralogs
for TGM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGM1 gene
- EPB422 TGM52 TGM42 TGM32 F13A12 TGM72 TGM22 TGM62
8 SIMAP similar genes for TGM1 using alignment to 9 protein entries: TGM1_HUMAN (see all proteins):TGM2 F13A1 TGM3 TGM4 EPB42 TGM6
TGM7 TGM5
TGM1 for paralogs About GeneDecksing
|
Genomic Variants
for TGM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGM1 (24718320 - 24733638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGM1: --
Human Gene Mutation Database (HGMD): TGM1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM1 |
|
Disorders
/ Diseases
for TGM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGM1 for disorders About GeneDecksing
OMIM gene information: 190195
OMIM disorders: 242300 242100
UniProtKB/Swiss-Prot: TGM1_HUMAN, P22735
Defects in TGM1 are the cause of ichthyosis lamellar type 1 (LI1) [MIM:242300]. LI is a non-bullousichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. It is one the most severe formsof ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a tight, shiny,translucent covering called collodion membrane. Over the first weeks of life, the collodion membrane is graduallyreplaced by generalized large, dark brown, plate-like scales with minimal to no erythroderma. Tautness of facial skincommonly results in ectropion, eclabium and scarring alopecia of the scalp. Common complications are severe heatintolerance and recurrent ear infections Defects in TGM1 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE isa non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affectedindividuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membranesubsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than inlamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. Incontrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severelyaffected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and lossof pulp volume Defects in TGM1 are the cause of ichthyosis congenital autosomal recessive TGM1-related (ARCI-TGM1)[MIM:242300]. A disorder of keratinization with abnormal differentiation and desquamation of the epidermis resultingin two major clinical entities. Lamellar ichthyosis is a condition often associated with an embedment in acollodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenitalichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownishscales are present on the buttocks, neck and legs
20/45  diseases for TGM1 (see all 45): About MalaCardscongenital ichthyosiform erythroderma self-healing collodion baby ichthyosis stevens-johnson syndrome
x-linked ichthyosis silver-russell syndrome beckwith-wiedemann syndrome autosomal recessive congenital ichthyosis
inclusion body myositis epidermolytic hyperkeratosis vohwinkel syndrome vohwinkel syndrome with ichthyosis
netherton syndrome ectropion ichthyosis vulgaris dermatitis herpetiformis
skin disease keratoderma renal agenesis kallmann syndrome
7 diseases from the University of Copenhagen DISEASES database for TGM1:Congenital ichthyosiform erythroderma Silver-Russell syndrome Beckwith-Wiedemann syndrome Skin disease
Ichthyosis vulgaris X-linked ichthyosis Lipoma of colon 10/21 Novoseek disease relationships for TGM1 gene (see all 21) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| congenital ichthyosis |
91.7 |
5 |
9326318 (1), 19556108 (1), 16634887 (1), 17635512 (1) (see all 5) |
| ichthyosis |
89.9 |
20 |
18165261 (3), 9506447 (2), 16968736 (1), 19438474 (1) (see all 13) |
| harlequin ichthyosis |
88.2 |
3 |
9486708 (1), 9049047 (1) |
| ichthyosiform erythroderma congenital |
87.9 |
8 |
11251583 (2), 16133457 (1), 9887377 (1), 10659499 (1) (see all 6) |
| skin diseases genetic |
75.1 |
1 |
9517915 (1) |
| hyperkeratosis |
71.1 |
1 |
11079322 (1) |
| keratoderma |
69.7 |
1 |
9517915 (1) |
| netherton syndrome |
56.2 |
2 |
17223863 (1) |
| skin diseases |
55.9 |
1 |
15061870 (1) |
| ichthyosis x-linked |
55.3 |
1 |
17468528 (1) |
GeneTests: TGM1
Autosomal Recessive Congenital Ichthyosis
Genetic Association Database (GAD): TGM1
Human Genome Epidemiology (HuGE) Navigator: TGM1 (7 documents)
Export disorders for TGM1 gene to outside databases
|
Publications
for TGM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGM1 gene, integrated from 9 sources (see all 243):
(articles sorted by number of sources associating them with TGM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1. (PubMed id 19241467)1, 2, 9 Herman M.L....Toro J.R. (2009)
- Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population. (PubMed id 9326318)1, 2, 9 Laiho E.... Palotie A. (1997)
- Novel mutations of TGM1 in a child with congenital ichthyosiform erythroderma. (PubMed id 11251583)1, 2, 9 Akiyama M.... Shimizu H. (2001)
- Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis. (PubMed id 7773290)1, 2, 9 Russell L.J.... Bale S.J. (1995)
- Mutations of keratinocyte transglutaminase in lamellar ichthyosis. (PubMed id 7824952)1, 2, 9 Huber M.... Hohl D. (1995)
- Novel mutations of the transglutaminase 1 gene in lamellar ichthyosis. (PubMed id 11511296)1, 2, 9 Yang J.M.... Steinert P.M. (2001)
- Type I keratinocyte transglutaminase: expression in human skin and psoriasis. (PubMed id 1351505)1, 2, 9 Schroeder W.... Duvic M. (1992)
- Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function. (PubMed id 1346394)1, 2, 9 Phillips M.A.... Rice R.H. (1992)
- Structure of the gene for human transglutaminase 1. (PubMed id 1381356)1, 2, 9 Yamanishi K.... Fukushima S. (1992)
- A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis. (PubMed id 17024410)1, 7, 9 Boeshans K.M....Ahvazi B. (2007)
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External Searches for TGM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TGM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TGM1 gene
(According to HUGE)
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Specialized Databases showing TGM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for TGM1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TGM1 | | NIEHS-SNPs | http://egp.gs.washington.edu/data/tgm1/ |
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| Patent Information for TGM1 gene:
Search GeneIP for patents involving TGM1
Licensable Technologies for TGM1 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TGM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TGM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGM1 | | | OriGene Protein Over-expression Lysate for TGM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TGM1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TGM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TGM1 | | OriGene Custom Protein Services for TGM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGM1 |
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| | | | Search Tocris compounds for TGM1 |
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 | | | TGM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGM1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TGM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGM1 |
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