TGIF2LY Gene
protein-coding GIFtS: 41
GCID: GC0YP003447
|
|
TGFB-induced factor homeobox 2-like, Y-linked(Previous names: TGFB-induced factor 2-like, Y-linked )
| |
Aliases
for TGIF2LY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TGFB-Induced Factor Homeobox 2-Like, Y-Linked1 2 | | TGFB-Induced Factor 2-Like Protein, Y-Linked2 3 | | TGIFLY2 3 5 | | TGIF-Like On The Y2 3 | | TGFB-Induced Factor 2-Like, Y-Linked1 2 | | Homeobox Protein TGIF2LY2 | | TGF-Beta-Induced Transcription Factor 2-Like Protein2 3 | | |
Export aliases for TGIF2LY gene to outside databasesPrevious GC identifers: GC0YP003412 GC0YP003150 GC0YP003490 |
Summaries
for TGIF2LY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TGIF2LY:
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the malespecific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Ytransposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggestingthat this protein may act as a regulator of TGIF2LX. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TF2LY_HUMAN, Q8IUE0Function: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX
|
Genomic Views
for TGIF2LY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011896.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGIF2LY gene promoter:
Oct-B1 POU2F2 (Oct-2.1) oct-B2 oct-B3 POU2F2 CREB POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGIF2LY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGIF2LY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TGIF2LY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP003447: view genomic region
(about GC identifiers)
Start:
|
3,447,082 bp from pter |
End:
|
3,448,082 bp from pter |
Size:
|
1,001 bases |
Orientation:
|
plus strand |
|
Proteins
for TGIF2LY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TF2LY_HUMAN, Q8IUE0 (See
protein sequence)Recommended Name: Homeobox protein TGIF2LY Size: 185 amino acids; 20814 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A2VCU1Explore the universe of human proteins at neXtProt for TGIF2LY: NX_Q8IUE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUE0
TGIF2LY Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_631960.1
ENSEMBL proteins: ENSP00000318502 ENSP00000453750
Human Recombinant Protein Products for TGIF2LY:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TGIF2LY for ontologies About GeneDecksing
TGIF2LY Antibody Products:
Assay Products for TGIF2LY: |
Protein
Domains /
Families
for TGIF2LY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGIF2LY for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUE0ProtoNet protein and cluster: Q8IUE0 UniProtKB/Swiss-Prot: TF2LY_HUMAN, Q8IUE0Similarity: Belongs to the TALE/TGIF homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for TGIF2LY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TF2LY_HUMAN, Q8IUE0Function: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
TGIF2LY for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGIF2LY (NM_139214) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGIF2LY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGIF2LY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LY |
|
Pathways & Interactions
for TGIF2LY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGIF2LY
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/71 Interacting proteins for TGIF2LY (Q8IUE02, 3 ENSP000003185024) via UniProtKB, MINT, STRING, and/or I2D (see all 71)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
TGIF2LY for ontologies About GeneDecksing
|
Drugs & Compounds
for TGIF2LY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGIF2LY
Search CenterWatch for drugs/clinical trials and news about TGIF2LY / TF2LY
|
Transcripts
for TGIF2LY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGIF2LY gene: NM_139214.2 Unigene Cluster for TGIF2LY: TGFB-induced factor homeobox 2-like, Y-linked Hs.112148 [show with all ESTs]Unigene Representative Sequence: AK2926092 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321217(uc004fqk.3) ENST00000559055(uc022ciw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TGIF2LY (NM_139214) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGIF2LY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGIF2LY |
Additional cDNA sequence: AF332223.1 AK292609.1 BC101143.1 BC101146.1 BC128604.1 1 DOTS entry: DT.453274 14 AceView cDNA sequences: BI827918 NM_139214 BX115529 AA629024 AI032362 AI554164 BV205025 BV205023 AF332223 BV205026 AA460136 AI041192 AI239522 AA460733
GeneLoc Exon Structure
|
Expression
for TGIF2LY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGIF2LY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TGIF2LY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGIF2LY
SOURCE GeneReport for Unigene cluster: Hs.112148
UniProtKB/Swiss-Prot: TF2LY_HUMAN, Q8IUE0Tissue specificity: Specifically expressed in adult testis
SABiosciences Custom PCR Arrays for TGIF2LY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGIF2LY
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TGIF2LY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGIF2LY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGIF2LY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LY |
Orthologs
for TGIF2LY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TGIF2LY gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for TGIF2LY (if available)
TreeFam Gene Tree for TGIF2LY (if available) |
Paralogs
for TGIF2LY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGIF2LY gene
- MEIS22 PKNOX12 MEIS32 TGIF22 PKNOX22 TGIF2LX2 TGIF12 MEIS12
10 SIMAP similar genes for TGIF2LY using alignment to 1 protein entry: TF2LY_HUMAN:TGIF2LX TGIF1 TGIF2 PKNOX2 MEIS3P1 MEIS3P2
MEIS3 MEIS2 PKNOX1 MEIS1
TGIF2LY for paralogs About GeneDecksing
|
Genomic Variants
for TGIF2LY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGIF2LY (3447082 - 3448082 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGIF2LY: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TGIF2LY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGIF2LY for disorders About GeneDecksing
OMIM gene information: 400025
OMIM disorders: --
4  diseases for TGIF2LY: About MalaCardsazoospermia infertility prostate cancer prostatitis
Export disorders for TGIF2LY gene to outside databases
|
Publications
for TGIF2LY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGIF2LY gene integrated from 9 sources:
(articles sorted by number of sources associating them with TGIF2LY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PubMed id 12226713)1, 2 Blanco-Arias P.... Affara N.A. (2002)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (2010)
- Association of TGIFLX/Y mRNA expression with prostate cancer. (PubMed id 18663611)1 Ousati Ashtiani Z....Heidari M. (2009)
- Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. (PubMed id 18384077)1 Aarabi M....Heidari M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TGIF2LY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TGIF2LY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGIF2LY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGIF2LY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TGIF2LY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TGIF2LY gene:
Search GeneIP for patents involving TGIF2LY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGIF2LY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TGIF2LY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGIF2LY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGIF2LY | | | OriGene Protein Over-expression Lysate for TGIF2LY | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TGIF2LY | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TGIF2LY | | OriGene Custom Protein Services for TGIF2LY | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGIF2LY | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGIF2LY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGIF2LY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGIF2LY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGIF2LY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGIF2LY |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TGIF2LY |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TGIF2LY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LY |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TGIF2LY |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGIF2LY |
| |  | |
|
|
|
