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Aliases for TGIF2LY Gene

Aliases for TGIF2LY Gene

  • TGFB-Induced Factor Homeobox 2-Like, Y-Linked 2 3
  • TGIFLY 3 4 6
  • TGF-Beta-Induced Transcription Factor 2-Like Protein 3 4
  • TGFB-Induced Factor 2-Like Protein, Y-Linked 3 4
  • TGFB-Induced Factor 2-Like, Y-Linked 2 3
  • TGIF-Like On The Y 3 4
  • Homeobox Protein TGIF2LY 3

External Ids for TGIF2LY Gene

Previous GeneCards Identifiers for TGIF2LY Gene

  • GC0YP003412
  • GC0YP003150
  • GC0YP003490
  • GC0YP003447

Summaries for TGIF2LY Gene

Entrez Gene Summary for TGIF2LY Gene

  • This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGIF2LY Gene

TGIF2LY (TGFB-Induced Factor Homeobox 2-Like, Y-Linked) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PKNOX1.

UniProtKB/Swiss-Prot for TGIF2LY Gene

  • May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2LY Gene

Genomics for TGIF2LY Gene

Regulatory Elements for TGIF2LY Gene

Genomic Location for TGIF2LY Gene

3,579,041 bp from pter
3,580,041 bp from pter
1,001 bases
Plus strand

Genomic View for TGIF2LY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGIF2LY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2LY Gene

Proteins for TGIF2LY Gene

  • Protein details for TGIF2LY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein TGIF2LY
    Protein Accession:
    Secondary Accessions:
    • A2VCU1

    Protein attributes for TGIF2LY Gene

    185 amino acids
    Molecular mass:
    20814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TGIF2LY Gene

Proteomics data for TGIF2LY Gene at MOPED

Post-translational modifications for TGIF2LY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGIF2LY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TGIF2LY Gene

Domains for TGIF2LY Gene

Gene Families for TGIF2LY Gene

  • TALE :Homeoboxes / TALE class

Protein Domains for TGIF2LY Gene

Suggested Antigen Peptide Sequences for TGIF2LY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IUE0
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2LY: view

Function for TGIF2LY Gene

Molecular function for TGIF2LY Gene

UniProtKB/Swiss-Prot Function: May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX

Gene Ontology (GO) - Molecular Function for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TGIF2LY: view

Animal Model Products

CRISPR Products

miRNA for TGIF2LY Gene

miRTarBase miRNAs that target TGIF2LY

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGIF2LY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TGIF2LY Gene

Localization for TGIF2LY Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2LY Gene

Subcellular locations from

Jensen Localization Image for TGIF2LY Gene COMPARTMENTS Subcellular localization image for TGIF2LY gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TGIF2LY: view

Pathways for TGIF2LY Gene

SuperPathways for TGIF2LY Gene

No Data Available

Gene Ontology (GO) - Biological Process for TGIF2LY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TGIF2LY: view

No data available for Pathways by source for TGIF2LY Gene

Transcripts for TGIF2LY Gene

mRNA/cDNA for TGIF2LY Gene

(14) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGIF2LY Gene

TGFB-induced factor homeobox 2-like, Y-linked:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGIF2LY

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TGIF2LY
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2LY Gene

No ASD Table

Relevant External Links for TGIF2LY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGIF2LY Gene

mRNA expression in normal human tissues for TGIF2LY Gene

mRNA differential expression in normal tissues according to GTEx for TGIF2LY Gene

This gene is overexpressed in Testis (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TGIF2LY Gene

SOURCE GeneReport for Unigene cluster for TGIF2LY Gene Hs.112148

mRNA Expression by UniProt/SwissProt for TGIF2LY Gene

Tissue specificity: Specifically expressed in adult testis
genes like me logo Genes that share expressions with TGIF2LY: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TGIF2LY Gene

Orthologs for TGIF2LY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2LY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGIF2LX 36
  • 64 (a)
(Canis familiaris)
Mammalia -- 36
  • 37 (a)
(Mus musculus)
Mammalia Tgif2lx1 36
  • 23 (a)
Tgif2lx2 36
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta achi 36
  • 9 (a)
vis 36
  • 9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUP9 36
  • 12 (a)
TOS8 36
  • 11 (a)
Species with no ortholog for TGIF2LY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGIF2LY Gene

Gene Tree for TGIF2LY (if available)
Gene Tree for TGIF2LY (if available)

Paralogs for TGIF2LY Gene

Paralogs for TGIF2LY Gene

Selected SIMAP similar genes for TGIF2LY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TGIF2LY: view

Variants for TGIF2LY Gene

Sequence variations from dbSNP and Humsavar for TGIF2LY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1053786 -- 3,579,810(+) CAGCC(A/G)AAGAA utr-variant-3-prime
rs1053787 -- 3,579,826(+) TCAAG(A/G)TTTCT utr-variant-3-prime
rs1053788 -- 3,579,837(+) ATCAC(A/T)TCCCC utr-variant-3-prime
rs1053790 -- 3,579,874(+) AGGAG(C/T)ACGCC utr-variant-3-prime
rs1053791 -- 3,579,923(+) ACAAA(C/G)GGCTG utr-variant-3-prime

Relevant External Links for TGIF2LY Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TGIF2LY Gene

Disorders for TGIF2LY Gene

No disorders were found for TGIF2LY Gene.

No data available for UniProtKB/Swiss-Prot for TGIF2LY Gene

Publications for TGIF2LY Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  2. The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PMID: 12226713) Blanco-Arias P. … Affara N.A. (Mamm. Genome 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. (PMID: 18384077) Aarabi M. … Heidari M. (Mol. Reprod. Dev. 2008) 3
  5. Association of TGIFLX/Y mRNA expression with prostate cancer. (PMID: 18663611) Ousati Ashtiani Z. … Heidari M. (Med. Oncol. 2009) 3

Products for TGIF2LY Gene

Sources for TGIF2LY Gene

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