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Aliases for TGIF2LX Gene

Aliases for TGIF2LX Gene

  • TGFB Induced Factor Homeobox 2 Like, X-Linked 2 3
  • TGFB-Induced Factor Homeobox 2-Like, X-Linked 2 3 5
  • TGF-Beta-Induced Transcription Factor 2-Like Protein 3 4
  • TGFB-Induced Factor 2-Like Protein, X-Linked 3 4
  • TGFB-Induced Factor 2-Like, X-Linked 2 3
  • TGIF-Like On The X 3 4
  • TGIFLX 3 4

External Ids for TGIF2LX Gene

Previous GeneCards Identifiers for TGIF2LX Gene

  • GC0XP084449
  • GC0XP086146
  • GC0XP087212
  • GC0XP087948
  • GC0XP088983
  • GC0XP089063
  • GC0XP089176

Summaries for TGIF2LX Gene

Entrez Gene Summary for TGIF2LX Gene

  • This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGIF2LX Gene

TGIF2LX (TGFB Induced Factor Homeobox 2 Like, X-Linked) is a Protein Coding gene. An important paralog of this gene is PKNOX1.

UniProtKB/Swiss-Prot for TGIF2LX Gene

  • May have a transcription role in testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2LX Gene

Genomics for TGIF2LX Gene

Regulatory Elements for TGIF2LX Gene

Enhancers for TGIF2LX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TGIF2LX on UCSC Golden Path with GeneCards custom track

Genomic Location for TGIF2LX Gene

89,921,882 bp from pter
89,922,883 bp from pter
1,002 bases
Plus strand

Genomic View for TGIF2LX Gene

Genes around TGIF2LX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF2LX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF2LX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2LX Gene

Proteins for TGIF2LX Gene

  • Protein details for TGIF2LX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein TGIF2LX
    Protein Accession:
    Secondary Accessions:
    • Q5JRM9
    • Q8TD48

    Protein attributes for TGIF2LX Gene

    241 amino acids
    Molecular mass:
    26675 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TGIF2LX Gene

neXtProt entry for TGIF2LX Gene

Proteomics data for TGIF2LX Gene at MOPED

Post-translational modifications for TGIF2LX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGIF2LX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TGIF2LX Gene

Domains & Families for TGIF2LX Gene

Gene Families for TGIF2LX Gene

Protein Domains for TGIF2LX Gene

Suggested Antigen Peptide Sequences for TGIF2LX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/TGIF homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2LX: view

Function for TGIF2LX Gene

Molecular function for TGIF2LX Gene

UniProtKB/Swiss-Prot Function:
May have a transcription role in testis.

Phenotypes for TGIF2LX Gene

GenomeRNAi human phenotypes for TGIF2LX:
genes like me logo Genes that share phenotypes with TGIF2LX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TGIF2LX Gene

Localization for TGIF2LX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2LX Gene

Subcellular locations from

Jensen Localization Image for TGIF2LX Gene COMPARTMENTS Subcellular localization image for TGIF2LX gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for TGIF2LX Gene

Pathways & Interactions for TGIF2LX Gene

SuperPathways for TGIF2LX Gene

No Data Available

Interacting Proteins for TGIF2LX Gene

Gene Ontology (GO) - Biological Process for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

No data available for Pathways by source and SIGNOR curated interactions for TGIF2LX Gene

Drugs & Compounds for TGIF2LX Gene

No Compound Related Data Available

Transcripts for TGIF2LX Gene

mRNA/cDNA for TGIF2LX Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGIF2LX Gene

TGFB-induced factor homeobox 2-like, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2LX Gene

No ASD Table

Relevant External Links for TGIF2LX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGIF2LX Gene

mRNA expression in normal human tissues for TGIF2LX Gene

mRNA differential expression in normal tissues according to GTEx for TGIF2LX Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for TGIF2LX Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGIF2LX Gene

SOURCE GeneReport for Unigene cluster for TGIF2LX Gene Hs.592220

mRNA Expression by UniProt/SwissProt for TGIF2LX Gene

Tissue specificity: Specifically expressed in adult testis.
genes like me logo Genes that share expression patterns with TGIF2LX: view

Protein tissue co-expression partners for TGIF2LX Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TGIF2LX Gene

Orthologs for TGIF2LX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2LX Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TGIF2LX 35
  • 75.15 (n)
  • 66.82 (a)
-- 36
  • 60 (a)
(Mus musculus)
Mammalia Tgif2lx2 35
  • 63.54 (n)
  • 48.07 (a)
Tgif2lx2 16
Tgif2lx1 36
  • 40 (a)
Tgif2lx2 36
  • 40 (a)
(Pan troglodytes)
Mammalia TGIF2LX 35
  • 99.17 (n)
  • 97.93 (a)
  • 98 (a)
fruit fly
(Drosophila melanogaster)
Insecta achi 36
  • 11 (a)
vis 36
  • 11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUP9 36
  • 14 (a)
TOS8 36
  • 13 (a)
Species with no ortholog for TGIF2LX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGIF2LX Gene

Gene Tree for TGIF2LX (if available)
Gene Tree for TGIF2LX (if available)

Paralogs for TGIF2LX Gene

Paralogs for TGIF2LX Gene

(4) SIMAP similar genes for TGIF2LX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGIF2LX: view

Variants for TGIF2LX Gene

Sequence variations from dbSNP and Humsavar for TGIF2LX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2290380 - 89,922,674(+) TTTCT(A/G)TCACA reference, missense
rs747975762 -- 89,922,500(+) GCACC(A/G)AGGCG reference, missense
rs748058637 -- 89,921,200(+) ATAAT(A/G)AGGTC upstream-variant-2KB
rs748295524 -- 89,923,350(+) GGCCA(A/G)TTTTG downstream-variant-500B
rs748373529 -- 89,922,334(+) GAGAA(A/G)CAAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TGIF2LX Gene

Variant ID Type Subtype PubMed ID
esv28140 CNV Gain+Loss 19812545
esv1007468 CNV Gain 20482838
dgv2455e1 CNV Complex 17122850

Variation tolerance for TGIF2LX Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TGIF2LX Gene

Disorders for TGIF2LX Gene

Relevant External Links for TGIF2LX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TGIF2LX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGIF2LX Gene

Publications for TGIF2LX Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons P.A. … Smith K.G. (N. Engl. J. Med. 2012) 3
  3. Association of TGIFLX/Y mRNA expression with prostate cancer. (PMID: 18663611) Ousati Ashtiani Z. … Heidari M. (Med. Oncol. 2009) 3
  4. Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. (PMID: 18384077) Aarabi M. … Heidari M. (Mol. Reprod. Dev. 2008) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TGIF2LX Gene

Sources for TGIF2LX Gene