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Aliases for TGIF2LX Gene

Aliases for TGIF2LX Gene

  • TGFB Induced Factor Homeobox 2 Like, X-Linked 2 3 5
  • TGF-Beta-Induced Transcription Factor 2-Like Protein 3 4
  • TGFB-Induced Factor 2-Like Protein, X-Linked 3 4
  • TGFB-Induced Factor 2-Like, X-Linked 2 3
  • TGIF-Like On The X 3 4
  • TGIFLX 3 4
  • TGFB-Induced Factor Homeobox 2-Like, X-Linked 2
  • Homeobox Protein TGIF2LX 3

External Ids for TGIF2LX Gene

Previous GeneCards Identifiers for TGIF2LX Gene

  • GC0XP084449
  • GC0XP086146
  • GC0XP087212
  • GC0XP087948
  • GC0XP088983
  • GC0XP089063
  • GC0XP089176

Summaries for TGIF2LX Gene

Entrez Gene Summary for TGIF2LX Gene

  • This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGIF2LX Gene

TGIF2LX (TGFB Induced Factor Homeobox 2 Like, X-Linked) is a Protein Coding gene. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot for TGIF2LX Gene

  • May have a transcription role in testis.

Additional gene information for TGIF2LX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2LX Gene

Genomics for TGIF2LX Gene

GeneHancer (GH) Regulatory Elements for TGIF2LX Gene

Promoters and enhancers for TGIF2LX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI089921 Promoter 0.7 EPDnew 550.8 +0.0 7 0.1 ATF1 CREB1 ATF2 TGIF2LX PIR50639
GH0XI089709 Enhancer 0.2 dbSUPER 0.1 -212.5 -212493 0.6 PIR54569 TGIF2LX
GH0XI089710 Enhancer 0.2 dbSUPER 0.1 -211.7 -211665 1 PIR54569 TGIF2LX
GH0XI089704 Enhancer 0.2 dbSUPER 0.1 -215.1 -215107 4.2 PIR54569 TGIF2LX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TGIF2LX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TGIF2LX gene promoter:

Genomic Locations for TGIF2LX Gene

Genomic Locations for TGIF2LX Gene
1,002 bases
Plus strand

Genomic View for TGIF2LX Gene

Genes around TGIF2LX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF2LX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF2LX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2LX Gene

Proteins for TGIF2LX Gene

  • Protein details for TGIF2LX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein TGIF2LX
    Protein Accession:
    Secondary Accessions:
    • Q5JRM9
    • Q8TD48

    Protein attributes for TGIF2LX Gene

    241 amino acids
    Molecular mass:
    26675 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TGIF2LX Gene

neXtProt entry for TGIF2LX Gene

Post-translational modifications for TGIF2LX Gene

No Post-translational modifications

Other Protein References for TGIF2LX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TGIF2LX Gene

Domains & Families for TGIF2LX Gene

Gene Families for TGIF2LX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TGIF2LX Gene

Suggested Antigen Peptide Sequences for TGIF2LX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TALE/TGIF homeobox family.
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2LX: view

Function for TGIF2LX Gene

Molecular function for TGIF2LX Gene

UniProtKB/Swiss-Prot Function:
May have a transcription role in testis.

Phenotypes From GWAS Catalog for TGIF2LX Gene

Gene Ontology (GO) - Molecular Function for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

Phenotypes for TGIF2LX Gene

GenomeRNAi human phenotypes for TGIF2LX:
genes like me logo Genes that share phenotypes with TGIF2LX: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TGIF2LX Gene

Localization for TGIF2LX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2LX Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGIF2LX gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

Pathways & Interactions for TGIF2LX Gene

SuperPathways for TGIF2LX Gene

No Data Available

Gene Ontology (GO) - Biological Process for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

No data available for Pathways by source and SIGNOR curated interactions for TGIF2LX Gene

Drugs & Compounds for TGIF2LX Gene

No Compound Related Data Available

Transcripts for TGIF2LX Gene

mRNA/cDNA for TGIF2LX Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGIF2LX Gene

TGFB-induced factor homeobox 2-like, X-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2LX Gene

No ASD Table

Relevant External Links for TGIF2LX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGIF2LX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGIF2LX Gene

mRNA differential expression in normal tissues according to GTEx for TGIF2LX Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for TGIF2LX Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TGIF2LX Gene

Protein tissue co-expression partners for TGIF2LX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TGIF2LX Gene:


SOURCE GeneReport for Unigene cluster for TGIF2LX Gene:


mRNA Expression by UniProt/SwissProt for TGIF2LX Gene:

Tissue specificity: Specifically expressed in adult testis.

Evidence on tissue expression from TISSUES for TGIF2LX Gene

  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with TGIF2LX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF2LX Gene

Orthologs for TGIF2LX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2LX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGIF2LX 33 34
  • 99.17 (n)
(Canis familiaris)
Mammalia TGIF2LX 33
  • 75.15 (n)
-- 34
  • 60 (a)
(Mus musculus)
Mammalia Tgif2lx2 33 16 34
  • 63.54 (n)
Tgif2lx1 34
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta achi 34
  • 11 (a)
vis 34
  • 11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUP9 34
  • 14 (a)
TOS8 34
  • 13 (a)
Species where no ortholog for TGIF2LX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGIF2LX Gene

Gene Tree for TGIF2LX (if available)
Gene Tree for TGIF2LX (if available)

Paralogs for TGIF2LX Gene

Paralogs for TGIF2LX Gene

(4) SIMAP similar genes for TGIF2LX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGIF2LX: view

Variants for TGIF2LX Gene

Sequence variations from dbSNP and Humsavar for TGIF2LX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000242752 -- 89,922,123(+) G/C coding_sequence_variant, missense_variant
rs1001514073 -- 89,921,244(+) G/A upstream_transcript_variant
rs1001566618 -- 89,920,687(+) G/A upstream_transcript_variant
rs1001795653 -- 89,921,637(+) G/A upstream_transcript_variant
rs1008364760 -- 89,920,379(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TGIF2LX Gene

Variant ID Type Subtype PubMed ID
esv1007468 CNV gain 20482838
esv2758876 CNV gain 17122850
esv28140 CNV gain+loss 19812545

Variation tolerance for TGIF2LX Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TGIF2LX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGIF2LX Gene

Disorders for TGIF2LX Gene

Additional Disease Information for TGIF2LX

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TGIF2LX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TGIF2LX Gene

Publications for TGIF2LX Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  4. The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PMID: 12226713) Blanco-Arias P … Affara NA (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TGIF2LX Gene

Sources for TGIF2LX Gene

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