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Aliases for TGIF2LX Gene

Aliases for TGIF2LX Gene

  • TGFB-Induced Factor Homeobox 2-Like, X-Linked 2 3
  • TGIFLX 3 4 6
  • TGF-Beta-Induced Transcription Factor 2-Like Protein 3 4
  • TGFB-Induced Factor 2-Like Protein, X-Linked 3 4
  • TGFB-Induced Factor 2-Like, X-Linked 2 3
  • TGIF-Like On The X 3 4
  • Homeobox Protein TGIF2LX 3

External Ids for TGIF2LX Gene

Previous GeneCards Identifiers for TGIF2LX Gene

  • GC0XP084449
  • GC0XP086146
  • GC0XP087212
  • GC0XP087948
  • GC0XP088983
  • GC0XP089063
  • GC0XP089176

Summaries for TGIF2LX Gene

Entrez Gene Summary for TGIF2LX Gene

  • This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008]

GeneCards Summary for TGIF2LX Gene

TGIF2LX (TGFB-Induced Factor Homeobox 2-Like, X-Linked) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TGIF2LY.

UniProtKB/Swiss-Prot for TGIF2LX Gene

  • May have a transcription role in testis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2LX Gene

Genomics for TGIF2LX Gene

Regulatory Elements for TGIF2LX Gene

Genomic Location for TGIF2LX Gene

Start:
89,921,882 bp from pter
End:
89,922,883 bp from pter
Size:
1,002 bases
Orientation:
Plus strand

Genomic View for TGIF2LX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGIF2LX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2LX Gene

Proteins for TGIF2LX Gene

  • Protein details for TGIF2LX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUE1-TF2LX_HUMAN
    Recommended name:
    Homeobox protein TGIF2LX
    Protein Accession:
    Q8IUE1
    Secondary Accessions:
    • Q5JRM9
    • Q8TD48

    Protein attributes for TGIF2LX Gene

    Size:
    241 amino acids
    Molecular mass:
    26675 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TGIF2LX Gene

neXtProt entry for TGIF2LX Gene

Proteomics data for TGIF2LX Gene at MOPED

Post-translational modifications for TGIF2LX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TGIF2LX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TGIF2LX Gene

Domains for TGIF2LX Gene

Gene Families for TGIF2LX Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Protein Domains for TGIF2LX Gene

Suggested Antigen Peptide Sequences for TGIF2LX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUE1

UniProtKB/Swiss-Prot:

TF2LX_HUMAN :
  • Q8IUE1
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2LX: view

Function for TGIF2LX Gene

Molecular function for TGIF2LX Gene

UniProtKB/Swiss-Prot Function: May have a transcription role in testis

Gene Ontology (GO) - Molecular Function for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

Phenotypes for TGIF2LX Gene

GenomeRNAi human phenotypes for TGIF2LX:
genes like me logo Genes that share phenotypes with TGIF2LX: view

Animal Model Products

CRISPR Products

miRNA for TGIF2LX Gene

miRTarBase miRNAs that target TGIF2LX

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGIF2LX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TGIF2LX Gene

Localization for TGIF2LX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2LX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGIF2LX Gene COMPARTMENTS Subcellular localization image for TGIF2LX gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

Pathways for TGIF2LX Gene

SuperPathways for TGIF2LX Gene

No Data Available

Interacting Proteins for TGIF2LX Gene

Gene Ontology (GO) - Biological Process for TGIF2LX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TGIF2LX: view

No data available for Pathways by source for TGIF2LX Gene

Transcripts for TGIF2LX Gene

mRNA/cDNA for TGIF2LX Gene

(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TGIF2LX Gene

TGFB-induced factor homeobox 2-like, X-linked:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TGIF2LX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TGIF2LX
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2LX Gene

No ASD Table

Relevant External Links for TGIF2LX Gene

GeneLoc Exon Structure for
TGIF2LX
ECgene alternative splicing isoforms for
TGIF2LX

Expression for TGIF2LX Gene

mRNA expression in normal human tissues for TGIF2LX Gene

mRNA differential expression in normal tissues according to GTEx for TGIF2LX Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGIF2LX Gene

SOURCE GeneReport for Unigene cluster for TGIF2LX Gene Hs.592220

mRNA Expression by UniProt/SwissProt for TGIF2LX Gene

Q8IUE1-TF2LX_HUMAN
Tissue specificity: Specifically expressed in adult testis
genes like me logo Genes that share expressions with TGIF2LX: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TGIF2LX Gene

Orthologs for TGIF2LX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2LX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGIF2LX 35
  • 99.17 (n)
  • 97.93 (a)
TGIF2LX 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
TGIF2LX 35
  • 75.15 (n)
  • 66.82 (a)
mouse
(Mus musculus)
Mammalia Tgif2lx1 16
Tgif2lx1 36
  • 40 (a)
ManyToMany
Tgif2lx2 35
  • 63.54 (n)
  • 48.07 (a)
Tgif2lx2 36
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta achi 36
  • 11 (a)
ManyToMany
vis 36
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUP9 36
  • 14 (a)
ManyToMany
TOS8 36
  • 13 (a)
ManyToMany
Species with no ortholog for TGIF2LX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TGIF2LX Gene

ENSEMBL:
Gene Tree for TGIF2LX (if available)
TreeFam:
Gene Tree for TGIF2LX (if available)

Paralogs for TGIF2LX Gene

Paralogs for TGIF2LX Gene

Selected SIMAP similar genes for TGIF2LX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TGIF2LX: view

Variants for TGIF2LX Gene

Sequence variations from dbSNP and Humsavar for TGIF2LX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1053792 -- 89,922,849(+) CCCTT(A/G)TGTAC utr-variant-3-prime
rs2290380 - 89,922,674(+) TTTCT(A/G)TCACA missense, reference
rs2496938 -- 89,921,114(+) CATTC(A/G)AAAGA upstream-variant-2KB
rs2496939 -- 89,921,188(+) caagg(A/C)gggca upstream-variant-2KB
rs2496940 -- 89,921,403(+) tgggc(A/G)acaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TGIF2LX Gene

Variant ID Type Subtype PubMed ID
esv28140 CNV Gain+Loss 19812545
esv1007468 CNV Gain 20482838
dgv2455e1 CNV Complex 17122850

Relevant External Links for TGIF2LX Gene

HapMap Linkage Disequilibrium report
TGIF2LX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGIF2LX Gene

Disorders for TGIF2LX Gene

Relevant External Links for TGIF2LX

Genetic Association Database (GAD)
TGIF2LX
Human Genome Epidemiology (HuGE) Navigator
TGIF2LX
genes like me logo Genes that share disorders with TGIF2LX: view

No data available for UniProtKB/Swiss-Prot for TGIF2LX Gene

Publications for TGIF2LX Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PMID: 12226713) Blanco-Arias P. … Affara N.A. (Mamm. Genome 2002) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TGIF2LX Gene

Sources for TGIF2LX Gene

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