TGIF2LX Gene
protein-coding GIFtS: 41
GCID: GC0XP089176
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TGFB-induced factor homeobox 2-like, X-linked(Previous names: TGFB-induced factor 2-like, X-linked )
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Aliases
for TGIF2LX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TGFB-Induced Factor Homeobox 2-Like, X-Linked1 2 | | TGFB-Induced Factor 2-Like Protein, X-Linked2 3 | | TGIFLX2 3 5 | | TGIF-Like On The X2 3 | | TGFB-Induced Factor 2-Like, X-Linked1 2 | | Homeobox Protein TGIF2LX2 | | TGF-Beta-Induced Transcription Factor 2-Like Protein2 3 | | |
Export aliases for TGIF2LX gene to outside databasesPrevious GC identifers: GC0XP084449 GC0XP086146 GC0XP087212 GC0XP087948 GC0XP088983 GC0XP089063 |
Summaries
for TGIF2LX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TGIF2LX:
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expressionsuggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specificregion of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TF2LX_HUMAN, Q8IUE1Function: May have a transcription role in testis
|
Genomic Views
for TGIF2LX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGIF2LX gene promoter:
Oct-B1 POU2F2 (Oct-2.1) oct-B2 oct-B3 POU2F2 CREB POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGIF2LX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGIF2LX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.31 Ensembl cytogenetic band: Xq21.31 HGNC cytogenetic band: Xq21.31TGIF2LX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP089176: view genomic region
(about GC identifiers)
Start:
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89,176,881 bp from pter |
End:
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89,177,984 bp from pter |
Size:
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1,104 bases |
Orientation:
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plus strand |
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Proteins
for TGIF2LX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TF2LX_HUMAN, Q8IUE1 (See
protein sequence)Recommended Name: Homeobox protein TGIF2LX Size: 241 amino acids; 26675 Da
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from  and Proteopedia  for TGIF2LX:2DMN (3D)
Secondary accessions: Q5JRM9 Q8TD48Explore the universe of human proteins at neXtProt for TGIF2LX: NX_Q8IUE1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUE1
TGIF2LX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620410.3
ENSEMBL proteins: ENSP00000355119 ENSP00000453704
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TGIF2LX for ontologies About GeneDecksing
TGIF2LX Antibody Products:
Assay Products for TGIF2LX: |
Protein
Domains /
Families
for TGIF2LX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGIF2LX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUE1ProtoNet protein and cluster: Q8IUE1 UniProtKB/Swiss-Prot: TF2LX_HUMAN, Q8IUE1Similarity: Belongs to the TALE/TGIF homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for TGIF2LX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TF2LX_HUMAN, Q8IUE1Function: May have a transcription role in testis
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LX |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
TGIF2LX for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TGIF2LX:
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Pathways & Interactions
for TGIF2LX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGIF2LX
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
TGIF2LX for ontologies About GeneDecksing
|
Drugs & Compounds
for TGIF2LX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGIF2LX
Search CenterWatch for drugs/clinical trials and news about TGIF2LX / TF2LX
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Transcripts
for TGIF2LX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGIF2LX gene: NM_138960.3 Unigene Cluster for TGIF2LX: TGFB-induced factor homeobox 2-like, X-linked Hs.592220 [show with all ESTs]Unigene Representative Sequence: NM_1389602 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283891(uc004efe.3) ENST00000561129(uc022bzr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGIF2LX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TGIF2LX (NM_138960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGIF2LX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGIF2LX |
Additional cDNA sequence: AF497480.1 BC029920.2 BC101144.2 BC101145.1 BC117398.1 BC117400.1 1 DOTS entry: DT.97783734 6 AceView cDNA sequences: NM_138960 BC029920 BI830352 AF497480 AA608782 AA608783
GeneLoc Exon Structure
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Expression
for TGIF2LX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGIF2LX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TGIF2LX Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.592220
UniProtKB/Swiss-Prot: TF2LX_HUMAN, Q8IUE1Tissue specificity: Specifically expressed in adult testis
SABiosciences Custom PCR Arrays for TGIF2LX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGIF2LX
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TGIF2LX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGIF2LX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGIF2LX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LX |
Orthologs
for TGIF2LX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for TGIF2LX gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for TGIF2LX (if available)
TreeFam Gene Tree for TGIF2LX (if available) |
Paralogs
for TGIF2LX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGIF2LX gene
- TGIF2LY2 MEIS22 PKNOX12 MEIS32 TGIF22 PKNOX22 TGIF12 MEIS12
4 SIMAP similar genes for TGIF2LX using alignment to 2 protein entries: TF2LX_HUMAN (see all proteins):TGIF2LY TGIF1 TGIF2 WUGSC
TGIF2LX for paralogs About GeneDecksing
|
Genomic Variants
for TGIF2LX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGIF2LX (89176881 - 89177984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TGIF2LX
2 CNVs: 3268 74025 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TGIF2LX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGIF2LX for disorders About GeneDecksing
OMIM gene information: 300411
OMIM disorders: --
4  diseases for TGIF2LX: About MalaCardsazoospermia infertility prostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: TGIF2LX (1 document)
Export disorders for TGIF2LX gene to outside databases
|
Publications
for TGIF2LX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGIF2LX gene integrated from 9 sources:
(articles sorted by number of sources associating them with TGIF2LX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon. (PubMed id 12226713)1, 2 Blanco-Arias P.... Affara N.A. (2002)
- Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
- Association of TGIFLX/Y mRNA expression with prostate cancer. (PubMed id 18663611)1 Ousati Ashtiani Z....Heidari M. (2009)
- Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. (PubMed id 18384077)1 Aarabi M....Heidari M. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TGIF2LX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TGIF2LX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGIF2LX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGIF2LX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TGIF2LX | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TGIF2LX gene:
Search GeneIP for patents involving TGIF2LX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGIF2LX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TGIF2LX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGIF2LX |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGIF2LX |
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