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TGIF2-C20orf24 Gene

protein-coding   GIFtS: 17
GCID: GC20P035203

TGIF2-C20orf24 Readthrough

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TGIF2-C20orf24 Readthrough1 2
TGIF2-C20orf24 Protein2

External Ids:    HGNC: 446641   Entrez Gene: 1005279432   Ensembl: ENSG000002593997   

Export aliases for TGIF2-C20orf24 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGIF2-C20orf24 Gene:
This locus represents naturally occurring read-through transcription between the neighboring TGIF2 (TGFB-induced
factor homeobox 2) and C20orf24 (chromosome 20 open reading frame 24) genes. The read-through transcript encodes
a fusion protein that shares sequence identity with each individual gene product. (provided by RefSeq, Dec 2010)

GeneCards Summary for TGIF2-C20orf24 Gene:
TGIF2-C20orf24 (TGIF2-C20orf24 readthrough) is a protein-coding gene. Diseases associated with TGIF2-C20orf24 include ovarian cancer, and prostatitis. An important paralog of this gene is C20orf24.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TGIF2-C20orf24
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGIF2-C20orf24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

TGIF2-C20orf24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGIF2-C20orf24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P035203:  view genomic region     (about GC identifiers)

Start:
35,202,956 bp from pter      End:
35,240,960 bp from pter
Size:
38,005 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --
Explore proteomics data for TGIF2-C20orf24 at MOPED


See TGIF2-C20orf24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001186464.1  
ENSEMBL proteins: 
 ENSP00000454021  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
     
TGIF2-C20orf24 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----

TGIF2-C20orf24 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TGIF2-C20orf24 About    
See pathways by source

SuperPathContained pathways About
1Regulation of nuclear SMAD2/3 signaling
Regulation of nuclear SMAD2/3 signaling


1 BioSystems Pathway for TGIF2-C20orf24
    Regulation of nuclear SMAD2/3 signaling


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Interactions:

    Search GeneGlobe Interaction Network for TGIF2-C20orf24

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TGIF2-C20orf24



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TGIF2-C20orf24 gene: 
NM_001199535.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000558530(uc002xfo.3)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TGIF2-C20orf24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TGIF2-C20orf24 Protein Expression
    Custom PCR Arrays for TGIF2-C20orf24
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TGIF2-C20orf24 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves C20H20ORF246
Gallus gallus chromosome 20 open reading frame, hu...
65(a)
1 → many
20(464024-468380)
lizard
(Anolis carolinensis)
Reptilia --
--
60(a)
1 → many
4(138567511-138573783)
zebrafish
(Danio rerio)
Actinopterygii C23H20orf246
chromosome 20 open reading frame 24
65(a)
1 → many
23(2894249-2901300) ENSDARG00000074790
fruit fly
(Drosophila melanogaster)
Insecta CG121076
--
44(a)
1 → many
2R(3561951-3562867)
worm
(Caenorhabditis elegans)
Secernentea F44E7.96
Protein F44E7.9 (F44E7.9) mRNA, complete cds
34(a)
1 → many
V(5791228-5792073) WBGene00018431
        Species with no ortholog for TGIF2-C20orf24

ENSEMBL Gene Tree for TGIF2-C20orf24 (if available)
TreeFam Gene Tree for TGIF2-C20orf24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TGIF2-C20orf24 gene
C20orf242  

TGIF2-C20orf24 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TGIF2-C20orf24 (see all 188)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs800205391,2
C--35221687(+) GGTGGA/GTCTAG 1 -- int10--------
rs1879340881,2
--35222965(+) GAAACA/GGAGTC 1 -- int10--------
rs1438961061,2
--35223089(+) GAGTGC/TGCCAC 1 -- int10--------
rs1924069421,2
--35223163(+) ATCTCA/GATCTC 1 -- int10--------
rs1844405891,2
--35223270(+) CACACA/GTGAAA 1 -- int10--------
rs1893713781,2
--35223272(+) CACATG/TAAAGT 1 -- int10--------
rs60282671,2
C,H--35223451(+) CCATCT/GTTTTT 1 -- int19Minor allele frequency- G:0.00NA WA CSA EA 253
rs1927711031,2
--35223548(+) GAGCTC/TGAATT 1 -- int10--------
rs1848460091,2
--35223549(+) AGCTCA/GAATTC 1 -- int10--------
rs775971261,2
C,F--35223603(+) GAACCT/CACCTG 1 -- int11Minor allele frequency- C:0.04NA 120

HapMap Linkage Disequilibrium report for TGIF2-C20orf24 (35202956 - 35240960 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TGIF2-C20orf24: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TGIF2-C20orf24
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for TGIF2-C20orf24:    
About MalaCards
ovarian cancer    prostatitis


TGIF2-C20orf24 for disorders           About GeneDecksing


Export disorders for TGIF2-C20orf24 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for TGIF2-C20orf24 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TGIF2-C20orf24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100527943 HGNC: 44664 Ensembl:ENSG00000259399 euGenes: HUgn100527943 ECgene: TGIF2-C20orf24
H-InvDB: TGIF2-C20orf24

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TGIF2-C20orf24 gene:
Search GeneIP for patents involving TGIF2-C20orf24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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