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Aliases for TGIF2 Gene

Aliases for TGIF2 Gene

  • TGFB Induced Factor Homeobox 2 2 3 5
  • TGFB-Induced Factor 2 (TALE Family Homeobox) 2
  • TGF-Beta-Induced Transcription Factor 2 4
  • TGFB-Induced Factor Homeobox 2 2
  • 5-TG-3-Interacting Factor 2 4
  • TGFB-Induced Factor 2 4

External Ids for TGIF2 Gene

Previous GeneCards Identifiers for TGIF2 Gene

  • GC20P034930
  • GC20P035840
  • GC20P035887
  • GC20P034635
  • GC20P035201
  • GC20P031911

Summaries for TGIF2 Gene

Entrez Gene Summary for TGIF2 Gene

  • The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for TGIF2 Gene

TGIF2 (TGFB Induced Factor Homeobox 2) is a Protein Coding gene. Diseases associated with TGIF2 include Holoprosencephaly-4. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and TGF-beta signaling pathway (KEGG). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TGIF1.

UniProtKB/Swiss-Prot for TGIF2 Gene

  • Transcriptional repressor, which probably repress transcription by binding directly the 5-CTGTCAA-3 DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Gene Wiki entry for TGIF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGIF2 Gene

Genomics for TGIF2 Gene

Regulatory Elements for TGIF2 Gene

Enhancers for TGIF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G036459 1.7 Ensembl ENCODE dbSUPER 15.8 -106.7 -106710 13.6 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 RBM12 CPNE1 AAR2 RBL1 TGIF2 RPL36P4 TLDC2 MYL9 PIR36954 GC20P036463
GH20G035765 1.8 FANTOM5 ENCODE dbSUPER 12 -803.9 -803928 9.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPL36P4 TGIF2 RBM39
GH20G036540 1.5 FANTOM5 ENCODE dbSUPER 12.3 -30.5 -30507 5.3 HDGF SIN3A YY1 TCF12 ZNF121 GLIS2 GATA2 ELK1 FOS ZNF263 RBM12 CPNE1 MYL9 RPL36P4 TLDC2 AAR2 TGIF2 RBL1 DLGAP4 GC20P036550
GH20G037142 1.1 ENCODE 12 +569.5 569450 1.3 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 AAR2 RBL1 TLDC2 TGIF2 RPN2 MROH8 MANBAL RPRD1B TTI1 LOC100419562
GH20G037356 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4 +784.4 784379 3.7 BCOR ESRRA WRNIP1 ZMYM3 EBF1 POLR2A EED SCRT2 MAFK PAF1 SRC MANBAL SAMHD1 TGIF2 CTNNBL1 GC20M037240 RPL7AP14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TGIF2 on UCSC Golden Path with GeneCards custom track

Promoters for TGIF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136712 727 2001 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for TGIF2 Gene

Chromosome:
20
Start:
36,573,473 bp from pter
End:
36,593,952 bp from pter
Size:
20,480 bases
Orientation:
Plus strand

Genomic View for TGIF2 Gene

Genes around TGIF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGIF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGIF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGIF2 Gene

Proteins for TGIF2 Gene

  • Protein details for TGIF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN2-TGIF2_HUMAN
    Recommended name:
    Homeobox protein TGIF2
    Protein Accession:
    Q9GZN2
    Secondary Accessions:
    • B2R9U3
    • E1P5T9
    • H0YNI0

    Protein attributes for TGIF2 Gene

    Size:
    237 amino acids
    Molecular mass:
    25878 Da
    Quaternary structure:
    • Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.
    Miscellaneous:
    • TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.
    SequenceCaution:
    • Sequence=BX377269; Type=Frameshift; Positions=87, 118; Evidence={ECO:0000305};

    Alternative splice isoforms for TGIF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGIF2 Gene

Post-translational modifications for TGIF2 Gene

  • The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TGIF2 Gene

Domains & Families for TGIF2 Gene

Gene Families for TGIF2 Gene

Protein Domains for TGIF2 Gene

Suggested Antigen Peptide Sequences for TGIF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZN2

UniProtKB/Swiss-Prot:

TGIF2_HUMAN :
  • Belongs to the TALE/TGIF homeobox family.
Family:
  • Belongs to the TALE/TGIF homeobox family.
genes like me logo Genes that share domains with TGIF2: view

Function for TGIF2 Gene

Molecular function for TGIF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor, which probably repress transcription by binding directly the 5-CTGTCAA-3 DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Gene Ontology (GO) - Molecular Function for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11006116
genes like me logo Genes that share ontologies with TGIF2: view
genes like me logo Genes that share phenotypes with TGIF2: view

Animal Models for TGIF2 Gene

MGI Knock Outs for TGIF2:

Animal Model Products

CRISPR Products

Targeted motifs for TGIF2 Gene
HOMER Transcription Factor Regulatory Elements motif TGIF2
  • Consensus sequence: TGTCANYT Submotif: canonical Cell Type: mES GEO ID: GSE55404

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TGIF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TGIF2 Gene

Localization for TGIF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGIF2 Gene

Nucleus. Note=Excluded from nucleoli.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGIF2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11006116
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TGIF2: view

Pathways & Interactions for TGIF2 Gene

genes like me logo Genes that share pathways with TGIF2: view

Gene Ontology (GO) - Biological Process for TGIF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11006116
GO:0010470 regulation of gastrulation IEA --
GO:0038092 nodal signaling pathway IEA --
genes like me logo Genes that share ontologies with TGIF2: view

No data available for SIGNOR curated interactions for TGIF2 Gene

Drugs & Compounds for TGIF2 Gene

No Compound Related Data Available

Transcripts for TGIF2 Gene

Unigene Clusters for TGIF2 Gene

TGFB-induced factor homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TGIF2

Alternative Splicing Database (ASD) splice patterns (SP) for TGIF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - - - -
SP7: - - - - - -

Relevant External Links for TGIF2 Gene

GeneLoc Exon Structure for
TGIF2
ECgene alternative splicing isoforms for
TGIF2

Expression for TGIF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGIF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TGIF2 Gene

This gene is overexpressed in Platelet (52.3) and Heart (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TGIF2 Gene



Protein tissue co-expression partners for TGIF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TGIF2 Gene:

TGIF2

SOURCE GeneReport for Unigene cluster for TGIF2 Gene:

Hs.632264

mRNA Expression by UniProt/SwissProt for TGIF2 Gene:

Q9GZN2-TGIF2_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Evidence on tissue expression from TISSUES for TGIF2 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TGIF2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TGIF2 Gene

Orthologs for TGIF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGIF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGIF2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7148 35
  • 93 (a)
OneToMany
Tgif2 34 16 35
  • 88.65 (n)
dog
(Canis familiaris)
Mammalia TGIF2 34 35
  • 91.56 (n)
cow
(Bos Taurus)
Mammalia TGIF2 34 35
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Tgif2 34
  • 89.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TGIF2 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGIF2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TGIF2 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGIF2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tgif2 34
  • 58.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535338 34
  • 59.49 (n)
TGIF2 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta achi 36 35
  • 72 (a)
vis 36 35
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS8 35
  • 15 (a)
ManyToMany
CUP9 35
  • 14 (a)
ManyToMany
Species where no ortholog for TGIF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGIF2 Gene

ENSEMBL:
Gene Tree for TGIF2 (if available)
TreeFam:
Gene Tree for TGIF2 (if available)

Paralogs for TGIF2 Gene

Paralogs for TGIF2 Gene

(12) SIMAP similar genes for TGIF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TGIF2 Gene

genes like me logo Genes that share paralogs with TGIF2: view

Variants for TGIF2 Gene

Sequence variations from dbSNP and Humsavar for TGIF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000256939 -- 36,586,386(+) GAAAT(C/G)ACTAA intron-variant
rs1000416318 -- 36,580,339(+) TGTAT(A/G)AGAAA intron-variant
rs1000556837 -- 36,586,513(+) AACAC(A/G)GTGAA intron-variant
rs1000775736 -- 36,586,163(+) TTCTA(-/T)TTTTC intron-variant
rs1000809647 -- 36,592,564(+) TCCAG(A/C)GAGGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TGIF2 Gene

Variant ID Type Subtype PubMed ID
nsv1057192 CNV loss 25217958
nsv833967 CNV loss 17160897

Variation tolerance for TGIF2 Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGIF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TGIF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGIF2 Gene

Disorders for TGIF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TGIF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
holoprosencephaly-4
  • holoprosencephaly 4
- elite association - COSMIC cancer census association via MalaCards
Search TGIF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TGIF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGIF2
genes like me logo Genes that share disorders with TGIF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGIF2 Gene

Publications for TGIF2 Gene

  1. TGIF2 interacts with histone deacetylase 1 and represses transcription. (PMID: 11427533) Melhuish T.A. … Wotton D. (J. Biol. Chem. 2001) 3 4 22 64
  2. Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. (PMID: 11006116) Imoto I. … Inazawa J. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for TGIF2 Gene

  • Addgene plasmids for TGIF2

Sources for TGIF2 Gene

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