TGFBRAP1 Gene
protein-coding GIFtS: 48
GCID: GC02M105880
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transforming growth factor, beta receptor associated protein...
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Aliases
for TGFBRAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transforming Growth Factor, Beta Receptor Associated Protein 11 2 | | TRAP11 2 3 5 | | TRAP-11 2 3 | | TGF-Beta Receptor-Associated Protein 12 3 | | TGF Beta Receptor Associated Protein -12 | | Transforming Growth Factor-Beta Receptor-Associated Protein 12 |
Export aliases for TGFBRAP1 gene to outside databasesPrevious GC identifers: GC02M104336 GC02M105488 GC02M105504 GC02M105342 GC02M099652 |
Summaries
for TGFBRAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2Function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta andactivin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. Mayrecruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads,such as SMAD2
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Genomic Views
for TGFBRAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGFBRAP1 gene promoter:
HOXA9B HOXA9 Sox5 Evi-1 E47 Meis-1b HFH-1 Zic1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGFBRAP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFBRAP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q12.1 Ensembl cytogenetic band: 2q12.1 HGNC cytogenetic band: 2q12.1TGFBRAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M105880: view genomic region
(about GC identifiers)
Start:
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105,880,871 bp from pter |
End:
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105,946,491 bp from pter |
Size:
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65,621 bases |
Orientation:
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minus strand |
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Proteins
for TGFBRAP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2 (See
protein sequence)Recommended Name: Transforming growth factor-beta receptor-associated protein 1 Size: 860 amino acids; 97158 Da
Subunit: Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1, BMPR1Aand ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the interaction seems tobe mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5
Subcellular location: Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling
Caution: In (PubMed:9545258) and in (PubMed:10051563) experimental information is given for a truncated version ofTGFBRAP1 (sequence of 474-860), which was later shown to act as a dominant negative
Secondary accessions: A8K5R7 D3DVJ8 O60466Explore the universe of human proteins at neXtProt for TGFBRAP1: NX_Q8WUH2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUH2
TGFBRAP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136093.1 NP_004248.2
ENSEMBL proteins: ENSP00000377027 ENSP00000258449
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TGFBRAP1 for ontologies About GeneDecksing
TGFBRAP1 Antibody Products:
Assay Products for TGFBRAP1: |
Protein
Domains /
Families
for TGFBRAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGFBRAP1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUH2ProtoNet protein and cluster: Q8WUH2 UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2Similarity: Belongs to the TRAP1 familySimilarity: Contains 1 CNH domain |
Function
for TGFBRAP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2Function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta andactivin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. Mayrecruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads,such as SMAD2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGFBRAP1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFBRAP1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TGFBRAP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for TGFBRAP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SMAD Signaling Network | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TGFBRAP1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGFBRAP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/15 Interacting proteins for TGFBRAP1 (Q8WUH23 ENSP000002584494) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TGFBRAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TGFBRAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGFBRAP1
Search CenterWatch for drugs/clinical trials and news about TGFBRAP1 / TGFA1
|
Transcripts
for TGFBRAP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGFBRAP1 gene (2 alternative transcripts): NM_001142621.1 NM_004257.4 Unigene Cluster for TGFBRAP1: Transforming growth factor, beta receptor associated protein 1 Hs.446350 [show with all ESTs]Unigene Representative Sequence: NM_0042572 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393359(uc010fjc.3 uc002tcq.3 uc002tcr.4) ENST00000258449
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGFBRAP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGFBRAP1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TGFBRAP1 (NM_001142621) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGFBRAP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFBRAP1 |
Additional cDNA sequence: AF022795.1 AK021697.1 AK291382.1 BC020548.2 6 DOTS entries: DT.409225 DT.100746909 DT.100746908 DT.120991824 DT.92425482 DT.95164817 24/157 AceView cDNA sequences (see all 157): AA829477 AI458508 BF197588 AU118757 AI435349 AI457845 BM676901 BQ788029 BM141729 AA777843 AL134300 BX115619 CA449205 AA485398 BG030857 AA516382 CB851910 AI458478 AI140559 AA701586 BC011136 AA304990 BQ672362 AI086249
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TGFBRAP1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TGFBRAP1
|
Expression
for TGFBRAP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGFBRAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAACCCCT
About this image
See TGFBRAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGFBRAP1
SOURCE GeneReport for Unigene cluster: Hs.446350
SABiosciences Expression via Pathway-Focused PCR Arrays including TGFBRAP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGFBRAP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFBRAP1 |
Orthologs
for TGFBRAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TGFBRAP1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TGFBRAP11 |
transforming growth factor, beta receptor associated more |
74.35(n)
78.93(a) |
|
418724 XM_416922.2 XP_416922.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TGFBRAP16 |
-- |
77(a) |
1 ↔ 1 |
3(108926570-108946741) |
zebrafish
(Danio rerio) |
Actinopterygii |
tgfbrap11 |
transforming growth factor, beta receptor associated more |
65.6(n)
63.95(a) |
|
565026 NM_001083554.1 NP_001077023.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G228606 |
Vacuolar sorting protein 39 |
15(a) |
1 ↔ 1 |
1(8083400-8089236) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
18(a) |
1 ↔ 1 |
5(218992-226339) |
ENSEMBL Gene Tree for TGFBRAP1 (if available)
TreeFam Gene Tree for TGFBRAP1 (if available) |
Paralogs
for TGFBRAP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGFBRAP1 gene
- VPS392
TGFBRAP1 for paralogs About GeneDecksing
|
Genomic Variants
for TGFBRAP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGFBRAP1 (105880871 - 105946491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGFBRAP1: --
Human Gene Mutation Database (HGMD): TGFBRAP1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TGFBRAP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGFBRAP1 for disorders About GeneDecksing
OMIM gene information: 606237
OMIM disorders: --
4  diseases for TGFBRAP1: About MalaCardshepatitis c t cell deficiency hepatitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: TGFBRAP1 (3 documents)
Export disorders for TGFBRAP1 gene to outside databases
|
Publications
for TGFBRAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGFBRAP1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TGFBRAP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. (PubMed id 11278302)1, 2, 3, 9 Wurthner J.U.... Roberts A.B. (2001)
- A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. (PubMed id 9545258)1, 2, 3 Charng M.J.... Schneider M.D. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)1, 2 Provost P.... Radmark O. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Conditional deletion of TGF-I^R1 using Langerin-Cre mi ce results in Langerhans cell deficiency and reduced contact hypersensitivity. (PubMed id 21998450)1 Zahner S.P....Clausen B.E. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
|
External Searches for TGFBRAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TGFBRAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGFBRAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGFBRAP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TGFBRAP1 gene:
Search GeneIP for patents involving TGFBRAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGFBRAP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGFBRAP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGFBRAP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFBRAP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGFBRAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFBRAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGFBRAP1 |
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