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TGFBRAP1 Gene

protein-coding   GIFtS: 52
GCID: GC02M105880

Transforming Growth Factor, Beta Receptor Associated Protein...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming Growth Factor, Beta Receptor Associated Protein 11 2
TRAP12 3 5
TRAP-12 3
TGF-Beta Receptor-Associated Protein 12 3
TGF Beta Receptor Associated Protein -12
Transforming Growth Factor-Beta Receptor-Associated Protein 12

External Ids:    HGNC: 168361   Entrez Gene: 93922   Ensembl: ENSG000001359667   OMIM: 6062375   UniProtKB: Q8WUH23   

Export aliases for TGFBRAP1 gene to outside databases

Previous GC identifers: GC02M104336 GC02M105488 GC02M105504 GC02M105342 GC02M099652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TGFBRAP1 Gene:
TGFBRAP1 (transforming growth factor, beta receptor associated protein 1) is a protein-coding gene. GO annotations related to this gene include transforming growth factor beta receptor binding and SMAD binding. An important paralog of this gene is VPS39.

UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2
Function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta
and activin receptor complexes, mainly through the type II receptor, and is released upon activation of
signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with
receptor-regulated Smads, such as SMAD2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGFBRAP1 gene promoter:
         HOXA9B   HOXA9   Sox5   Evi-1   E47   Meis-1b   HFH-1   Zic1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFBRAP1 promoter sequence
   Search Chromatin IP Primers for TGFBRAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFBRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

TGFBRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFBRAP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M105880:  view genomic region     (about GC identifiers)

Start:
105,880,871 bp from pter      End:
105,946,491 bp from pter
Size:
65,621 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2 (See protein sequence)
Recommended Name: Transforming growth factor-beta receptor-associated protein 1  
Size: 860 amino acids; 97158 Da
Subunit: Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1,
BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the
interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact
with ALOX5
Caution: In (PubMed:9545258) and in (PubMed:10051563) experimental information is given for a truncated version of
TGFBRAP1 (sequence of 474-860), which was later shown to act as a dominant negative
Secondary accessions: A8K5R7 D3DVJ8 O60466

Explore the universe of human proteins at neXtProt for TGFBRAP1: NX_Q8WUH2

Explore proteomics data for TGFBRAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys370, Lys630
  • Modification sites at PhosphoSitePlus

  • See TGFBRAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136093.1  NP_004248.2  

    ENSEMBL proteins: 
     ENSP00000377027   ENSP00000258449  

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    antibodies-online proteins for TGFBRAP1 (2 products) 

     
    antibodies-online peptides for TGFBRAP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001180 Citron
     IPR019452 VPS39/TGF_beta_rcpt-assoc_1
     IPR000547 Clathrin_H-chain/VPS_repeat
     IPR019453 VPS39/TGF_beta_rcpt-assoc_2

    Graphical View of Domain Structure for InterPro Entry Q8WUH2

    ProtoNet protein and cluster: Q8WUH2

    UniProtKB/Swiss-Prot: TGFA1_HUMAN, Q8WUH2
    Similarity: Belongs to the TRAP1 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 CNH domain


    Find genes that share domains with TGFBRAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFA1_HUMAN, Q8WUH2
    Function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta
    and activin receptor complexes, mainly through the type II receptor, and is released upon activation of
    signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with
    receptor-regulated Smads, such as SMAD2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005160transforming growth factor beta receptor binding IDA11278302
    GO:0005515protein binding IPI11278302
    GO:0046332SMAD binding IDA11278302
         
    Find genes that share ontologies with TGFBRAP1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TGFBRAP1

    miRNA
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    miRTarBase miRNAs that target TGFBRAP1:
    hsa-mir-628-3p (MIRT039586), hsa-mir-92a-3p (MIRT049371), hsa-mir-122-5p (MIRT023387)

    Block miRNA regulation of human, mouse, rat TGFBRAP1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TGFBRAP1:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTGFBRAP1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFBRAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGFA1_HUMAN, Q8WUH2: Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IDA11278302

    Find genes that share ontologies with TGFBRAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TGFBRAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1SMAD Signaling Network
    SMAD Signaling Network

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TGFBRAP1
        SMAD Signaling Network



        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFBRAP1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TGFBRAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGFBRAP1 (Q8WUH23 ENSP000002584494) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX5P099173, ENSP000003635124I2D: score=4 STRING: ENSP00000363512
    ACVR1BP368963, ENSP000002579634I2D: score=2 STRING: ENSP00000257963
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    TGFBR2P371733, ENSP000003519054I2D: score=2 STRING: ENSP00000351905
    ACVR2BQ137053, ENSP000003403614I2D: score=1 STRING: ENSP00000340361
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IDA11278302
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction IDA11278302
    GO:0007179transforming growth factor beta receptor signaling pathway TAS9545258
    GO:0016192vesicle-mediated transport IEA--

    Find genes that share ontologies with TGFBRAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGFBRAP1 (TGFA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TGFBRAP1 gene (2 alternative transcripts): 
    NM_001142621.2  NM_004257.5  

    Unigene Cluster for TGFBRAP1:

    Transforming growth factor, beta receptor associated protein 1
    Hs.446350  [show with all ESTs]
    Unigene Representative Sequence: NM_004257
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393359(uc010fjc.3 uc002tcq.3 uc002tcr.4) ENST00000258449

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TGFBRAP1:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTGFBRAP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TGFBRAP1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TGFBRAP1
      QuantiFast Probe-based Assays in human, mouse, rat TGFBRAP1

    Additional mRNA sequence: 

    AF022795.1 AK021697.1 AK291382.1 BC020548.2 

    6 DOTS entries:

    DT.409225  DT.100746909  DT.100746908  DT.120991824  DT.92425482  DT.95164817 

    Selected AceView cDNA sequences (see all 157):

    AI086249 AL135022 BG030857 BE894890 BG030587 BM676901 AI090122 BX115619 
    BM457015 BQ788029 AA829477 BC019841 BM672475 AI458478 AA777843 CA394377 
    BQ424023 BC011136 BQ013999 BQ672362 AL134300 AI140559 AA701586 AI457845 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TGFBRAP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                              
    SP2:                                                                              


    ECgene alternative splicing isoforms for TGFBRAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TGFBRAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACCCCT
    TGFBRAP1 Expression
    About this image

    TGFBRAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGFBRAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446350
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFBRAP1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TGFBRAP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfbrap11 , 5 transforming growth factor, beta receptor associated more1, 5 85.85(n)1
    89.3(a)1
      1 (22.13 cM)5
    731221  NM_001013025.21  NP_001013043.11 
     430472695 
    chicken
    (Gallus gallus)
    Aves TGFBRAP11 transforming growth factor, beta receptor associated more 74.35(n)
    78.93(a)
      418724  XM_416922.3  XP_416922.2 
    lizard
    (Anolis carolinensis)
    Reptilia TGFBRAP16
    transforming growth factor, beta receptor associat...
    77(a)
    1 ↔ 1
    3(108921707-108946741)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tgfbrap11 transforming growth factor, beta receptor associated more 65.17(n)
    67.53(a)
      100497663  XM_002941156.2  XP_002941202.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tgfbrap11 transforming growth factor, beta receptor associated more 65.6(n)
    63.95(a)
      565026  NM_001083554.1  NP_001077023.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71466
    --
    21(a)
    1 → many
    3R(14096908-14100168)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-396
    Protein VPS-39, isoform c (vps-39) mRNA, complete ...
    19(a)
    1 → many
    V(14034335-14038372) WBGene00011625
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VAM66
    Vacuolar protein that plays a critical role in the...
    11(a)
    1 → many
    IV(316971-320120) YDL077C


    ENSEMBL Gene Tree for TGFBRAP1 (if available)
    TreeFam Gene Tree for TGFBRAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TGFBRAP1 gene
    VPS392  

    Find genes that share paralogs with TGFBRAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGFBRAP1 (see all 1308)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501129831,2
    --105885291(+) GGCACA/GCCCAT 2 -- int10--------
    rs170307231,2
    C,F,H--105885309(+) GCATGC/AGACTG 2 -- int116Minor allele frequency- A:0.31NA NS EA WA CSA 932
    rs118910321,2
    C,F,A,H--105885332(+) ATTTCC/ATCTCC 2 -- int1 trp311Minor allele frequency- A:0.11NS EA NA WA 1312
    rs1384166181,2
    C--105885404(+) CATGAC/TGTAAA 2 -- int10--------
    rs1427562701,2
    --105885422(+) GGTCAA/GTGCCT 2 -- int10--------
    rs673077601,2
    C,F--105885432(+) TGGCAC/TACAGC 2 -- int14Minor allele frequency- T:0.13NA WA EA 360
    rs1888069731,2
    C--105885464(+) TATTCC/TGATGC 2 -- int10--------
    rs1179623711,2
    F--105885505(+) CCAGCG/ATCCAA 2 -- int11Minor allele frequency- A:0.03EA 120
    rs1475000951,2
    --105885571(+) TCACAA/CAGACC 2 -- int10--------
    rs2009906631,2
    --105885718(+) GGGGGC/TCAGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for TGFBRAP1 (105880871 - 105946491 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TGFBRAP1: --
    Human Gene Mutation Database (HGMD): TGFBRAP1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TGFBRAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFBRAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606237    OMIM disorders: --


    Find genes that share disorders with TGFBRAP1           About GenesLikeMe

    Genetic Association Database (GAD): TGFBRAP1
    Human Genome Epidemiology (HuGE) Navigator: TGFBRAP1 (3 documents)

    Export disorders for TGFBRAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGFBRAP1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TGFBRAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. (PubMed id 11278302)1, 2, 3, 9 Wurthner J.U.... Roberts A.B. (J. Biol. Chem. 2001)
    2. A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. (PubMed id 9545258)1, 2, 3 Charng M.-J.... Schneider M.D. (J. Biol. Chem. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). (PubMed id 19754311)1, 4 Le Clerc S....Zagury J.F. (J. Infect. Dis. 2009)
    5. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PubMed id 16886895)1, 4 Hwang Y....Chen D.S. (Pharmacogenomics 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)1, 2 Provost P.... Radmark O. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    8. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PubMed id 23551011)1 Zhao L....Dewan A.T. (Ann. Hum. Genet. 2013)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9392 HGNC: 16836 AceView: TGFBRAP1 Ensembl:ENSG00000135966 euGenes: HUgn9392
    ECgene: TGFBRAP1 H-InvDB: TGFBRAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGFBRAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFBRAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGFBRAP1 gene:
    Search GeneIP for patents involving TGFBRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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