TGFBR3L Gene
protein-coding GIFtS: 21
GCID: GC19P007982
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transforming growth factor, beta receptor III-like
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Aliases
for TGFBR3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transforming Growth Factor, Beta Receptor III-Like1 2 | | Transforming Growth Factor-Beta Receptor Type III-Like Protein2 3 | | TGFR-3L2 3 | | TGF-Beta Receptor Type III-Like Protein2 3 | | TGF-Beta Receptor Type-3-Like Protein2 3 | | Transforming Growth Factor-Beta Receptor Type 3-Like Protein2 |
Export aliases for TGFBR3L gene to outside databases |
Summaries
for TGFBR3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TGFBR3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TGFBR3L
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGFBR3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFBR3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2TGFBR3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P007982: view genomic region
(about GC identifiers)
Start:
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7,981,030 bp from pter |
End:
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7,983,982 bp from pter |
Size:
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2,953 bases |
Orientation:
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plus strand |
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Proteins
for TGFBR3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: TGR3L_HUMAN, H3BV60 (See
protein sequence)Recommended Name: Transforming growth factor-beta receptor type 3-like protein Size: 316 amino acids; 32819 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for TGFBR3L: NX_H3BV60
TGFBR3L Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001182188.1
ENSEMBL proteins: ENSP00000457962 ENSP00000456601
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
TGFBR3L for ontologies About GeneDecksing
TGFBR3L Antibody Products:
Assay Products for TGFBR3L: |
Protein
Domains /
Families
for TGFBR3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGFBR3L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry H3BV60ProtoNet protein and cluster: H3BV60 UniProtKB/Swiss-Prot: TGR3L_HUMAN, H3BV60Similarity: Contains 1 ZP domain |
Function
for TGFBR3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for TGFBR3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGFBR3L
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Drugs & Compounds
for TGFBR3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGFBR3L
Search CenterWatch for drugs/clinical trials and news about TGFBR3L / TGR3L 
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Transcripts
for TGFBR3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for TGFBR3L gene: NM_001195259.1 Unigene Cluster for TGFBR3L: Transforming growth factor, beta receptor III-like Hs.646773 [show with all ESTs]Unigene Representative Sequence: NM_0011952594 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565886(uc021uoa.1) ENST00000567774 ENST00000564348 ENST00000566166
3 DOTS entries: DT.70100630 DT.95291784 DT.92036271
GeneLoc Exon Structure
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Expression
for TGFBR3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SOURCE GeneReport for Unigene cluster: Hs.646773
SABiosciences Custom PCR Arrays for TGFBR3L
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TGFBR3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGFBR3L | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFBR3L |
Orthologs
for TGFBR3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for TGFBR3L gene from 2/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TGFBR3L6 |
-- |
26(a) |
1 ↔ 1 |
2(119680708-119684941) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01064405.16 |
-- |
8(a) |
1 → many |
3(6273243-6307324) |
Species with no ortholog for TGFBR3L
ENSEMBL Gene Tree for TGFBR3L (if available)
TreeFam Gene Tree for TGFBR3L (if available) |
Paralogs
for TGFBR3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGFBR3L gene
- ENG2 TGFBR32
TGFBR3L for paralogs About GeneDecksing
|
Genomic Variants
for TGFBR3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGFBR3L (7981030 - 7983982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGFBR3L: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TGFBR3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TGFBR3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for TGFBR3L gene integrated from 9 sources:
(articles sorted by number of sources associating them with TGFBR3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery of 342 putative new genes from the analysis of 5'-end-sequenced full-length-enriched cDNA human transcripts. (PubMed id 15885500)1, 2 Dalla E....Schneider C. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for TGFBR3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TGFBR3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TGFBR3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGFBR3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for TGFBR3L gene:
Search GeneIP for patents involving TGFBR3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGFBR3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGFBR3L | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGFBR3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFBR3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGFBR3L | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFBR3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGFBR3L |
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| | | | Search Tocris compounds for TGFBR3L |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TGFBR3L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TGFBR3L |
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