Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TGFBR3 Gene

Aliases for TGFBR3 Gene

  • Transforming Growth Factor Beta Receptor 3 2 3
  • Transforming Growth Factor Beta Receptor III 2 3 4 5
  • TGF-Beta Receptor Type III 3 4
  • TGF-Beta Receptor Type 3 3 4
  • Betaglycan Proteoglycan 2 3
  • Betaglycan 3 4
  • TGFR-3 3 4
  • Transforming Growth Factor, Beta Receptor III 2
  • BGCAN 3

External Ids for TGFBR3 Gene

Previous GeneCards Identifiers for TGFBR3 Gene

  • GC01M092604
  • GC01M091345
  • GC01M091485
  • GC01M091860
  • GC01M092145
  • GC01M090263

Summaries for TGFBR3 Gene

Entrez Gene Summary for TGFBR3 Gene

  • This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

GeneCards Summary for TGFBR3 Gene

TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a Protein Coding gene. Diseases associated with TGFBR3 include familial cerebral saccular aneurysm and megakaryocytic tumor. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include heparin binding and SMAD binding. An important paralog of this gene is TGFBR3L.

UniProtKB/Swiss-Prot for TGFBR3 Gene

  • Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Gene Wiki entry for TGFBR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFBR3 Gene

Genomics for TGFBR3 Gene

Regulatory Elements for TGFBR3 Gene

Genomic Location for TGFBR3 Gene

91,680,343 bp from pter
91,906,335 bp from pter
225,993 bases
Minus strand

Genomic View for TGFBR3 Gene

Genes around TGFBR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGFBR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGFBR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFBR3 Gene

Proteins for TGFBR3 Gene

  • Protein details for TGFBR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transforming growth factor beta receptor type 3
    Protein Accession:
    Secondary Accessions:
    • A0AUW8
    • A8K5N0
    • B9EG88
    • Q5T2T4
    • Q5U731
    • Q9UGI2

    Protein attributes for TGFBR3 Gene

    851 amino acids
    Molecular mass:
    93499 Da
    Quaternary structure:
    • Interacts with TCTEX1D4.
    • Sequence=AAA67061.1; Type=Frameshift; Positions=70, 73, 349, 350; Evidence={ECO:0000305};

    Alternative splice isoforms for TGFBR3 Gene


neXtProt entry for TGFBR3 Gene

Proteomics data for TGFBR3 Gene at MOPED

Post-translational modifications for TGFBR3 Gene

  • Extensively modified by glycosaminoglycan groups (GAG).
  • Glycosylation at Asn 141, Thr 369, Asn 492, Ser 534, Ser 545, Asn 571, Asn 590, and Asn 697
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TGFBR3 (TGF-beta RIII)
  • Cell Signaling Technology (CST) Antibodies for TGFBR3 (TGFBR3)

No data available for DME Specific Peptides for TGFBR3 Gene

Domains & Families for TGFBR3 Gene

Protein Domains for TGFBR3 Gene


Suggested Antigen Peptide Sequences for TGFBR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ZP domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with TGFBR3: view

Function for TGFBR3 Gene

Molecular function for TGFBR3 Gene

GENATLAS Biochemistry:
transforming growth factor beta,receptor type III
UniProtKB/Swiss-Prot Function:
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Gene Ontology (GO) - Molecular Function for TGFBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IEA,ISS 1333192
GO:0017134 fibroblast growth factor binding IEA --
GO:0070123 transforming growth factor beta receptor activity, type III IEA,IDA 10746731
genes like me logo Genes that share ontologies with TGFBR3: view
genes like me logo Genes that share phenotypes with TGFBR3: view

Human Phenotype Ontology for TGFBR3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TGFBR3 Gene

MGI Knock Outs for TGFBR3:

Animal Model Products

miRNA for TGFBR3 Gene

miRTarBase miRNAs that target TGFBR3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TGFBR3 Gene

Localization for TGFBR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFBR3 Gene

Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Subcellular locations from

Jensen Localization Image for TGFBR3 Gene COMPARTMENTS Subcellular localization image for TGFBR3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TGFBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IDA 12958365
genes like me logo Genes that share ontologies with TGFBR3: view

Pathways & Interactions for TGFBR3 Gene

genes like me logo Genes that share pathways with TGFBR3: view

SIGNOR curated interactions for TGFBR3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TGFBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development ISS --
GO:0006461 protein complex assembly IEA --
GO:0006955 immune response IMP 16886151
GO:0007181 transforming growth factor beta receptor complex assembly IEA --
genes like me logo Genes that share ontologies with TGFBR3: view

Drugs & Compounds for TGFBR3 Gene

(4) Drugs for TGFBR3 Gene - From: DGIdb, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antidepressants Pharma 0
TG-C Pharma 0

(1) Additional Compounds for TGFBR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TGFBR3: view

Transcripts for TGFBR3 Gene

Unigene Clusters for TGFBR3 Gene

Transforming growth factor, beta receptor III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGFBR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TGFBR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TGFBR3 Gene

mRNA expression in normal human tissues for TGFBR3 Gene

Protein differential expression in normal tissues from HIPED for TGFBR3 Gene

This gene is overexpressed in Serum (22.4), Urine (9.3), Urinary Bladder (8.8), and Ovary (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGFBR3 Gene

SOURCE GeneReport for Unigene cluster for TGFBR3 Gene Hs.482390

genes like me logo Genes that share expression patterns with TGFBR3: view

Protein tissue co-expression partners for TGFBR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TGFBR3 Gene

Orthologs for TGFBR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGFBR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TGFBR3 35
  • 99.26 (n)
  • 99.29 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TGFBR3 36
  • 87 (a)
  • 88.5 (n)
  • 87.75 (a)
(Canis familiaris)
Mammalia TGFBR3 35
  • 89.8 (n)
  • 89.76 (a)
  • 89 (a)
(Mus musculus)
Mammalia Tgfbr3 16
Tgfbr3 36
  • 81 (a)
Tgfbr3 35
  • 84.2 (n)
  • 82.15 (a)
(Monodelphis domestica)
Mammalia TGFBR3 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
-- 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Tgfbr3 35
  • 83.67 (n)
  • 82.29 (a)
(Gallus gallus)
Aves TGFBR3 35
  • 70.01 (n)
  • 69.08 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia TGFBR3 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tgfbr3 35
  • 63.5 (n)
  • 60.77 (a)
(Danio rerio)
Actinopterygii tgfbr3 36
  • 49 (a)
tgfbr3 35
  • 57.21 (n)
  • 51.09 (a)
Species with no ortholog for TGFBR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGFBR3 Gene

Gene Tree for TGFBR3 (if available)
Gene Tree for TGFBR3 (if available)

Paralogs for TGFBR3 Gene

Paralogs for TGFBR3 Gene

genes like me logo Genes that share paralogs with TGFBR3: view

Variants for TGFBR3 Gene

Sequence variations from dbSNP and Humsavar for TGFBR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1805110 - 91,861,488(-) GAGCT(C/T)CTGTT nc-transcript-variant, reference, missense
rs17884205 - 91,861,491(-) GATGA(A/G)CTCCT nc-transcript-variant, reference, missense
rs17885124 - 91,734,856(-) AAATT(G/T)GGCCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17882578 - 91,712,506(-) GATTT(A/G)CCATC nc-transcript-variant, reference, missense
rs17882828 - 91,698,125(-) AAAAA(C/G)GTCCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TGFBR3 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv528991 CNV Loss 19592680
nsv462517 CNV Gain 19166990
nsv524845 CNV Gain 19592680
esv988308 CNV Deletion 20482838
esv2714795 CNV Deletion 23290073
esv2661714 CNV Deletion 23128226
esv989733 CNV Deletion 20482838
esv25877 CNV Loss 19812545
nsv823520 CNV Loss 20364138
nsv525320 CNV Loss 19592680
nsv519291 CNV Loss 19592680
nsv830581 CNV Loss 17160897
dgv264n71 CNV Gain 21882294
esv2750842 CNV Gain 17911159

Variation tolerance for TGFBR3 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGFBR3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFBR3 Gene

Disorders for TGFBR3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TGFBR3 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
familial cerebral saccular aneurysm
  • familial berry aneurysm
megakaryocytic tumor
  • megakaryocytic neoplasm
bone fracture
eisenmenger syndrome
  • eisenmenger complex
intermediate uveitis
  • chronic cyclitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TGFBR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TGFBR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGFBR3 Gene

Publications for TGFBR3 Gene

  1. Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. (PMID: 1333192) Moren A. … Miyazono K. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. (PMID: 20208565) Cooper S.J. … Copland J.A. (Oncogene 2010) 3 23
  3. Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. (PMID: 19131638) Hersh C.P. … Silverman E.K. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23
  4. Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity. (PMID: 19639191) Bae H.J. … Nam S.W. (Oncol. Rep. 2009) 3 23
  5. Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. (PMID: 18184661) Kirkbride K.C. … Blobe G.C. (J. Biol. Chem. 2008) 3 23

Products for TGFBR3 Gene

Sources for TGFBR3 Gene

Back to Top