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TGFBR2 Gene

protein-coding   GIFtS: 77
GCID: GC03P030623

Transforming Growth Factor, Beta Receptor II (70/80kDa)

(Previous names: transforming growth factor, beta receptor II (70-80kD))
(Previous symbol: MFS2)
  See TGFBR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming Growth Factor, Beta Receptor II (70/80kDa)1 2     TGFbeta-RII2
MFS21 2 5     tbetaR-II2
TGFR-22 3     TGF-Beta Receptor Type IIB2
TGF-Beta Type II Receptor2 3     TGF-Beta Receptor Type-22
EC 2.7.11.303 8     Transforming Growth Factor Beta Receptor Type IIC2
AAT32 5     TbetaR-II3
Transforming Growth Factor, Beta Receptor II (70-80kD)1     TGF-Beta Receptor Type II3
FAA32     Transforming Growth Factor-Beta Receptor Type II3
LDS1B2     HNPCC65
LDS2B2     LDS25
RIIC2     EC 2.7.118
TAAD22     

External Ids:    HGNC: 117731   Entrez Gene: 70482   Ensembl: ENSG000001635137   OMIM: 1901825   UniProtKB: P371733   

Export aliases for TGFBR2 gene to outside databases

Previous GC identifers: GC03M030227 GC03M029766 GC03P030497 GC03P030622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGFBR2 Gene:
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded
protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another
receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the
nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene
have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various
types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TGFBR2 Gene:
TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)) is a protein-coding gene. Diseases associated with TGFBR2 include loeys-dietz syndrome, and aneurysm. GO annotations related to this gene include mitogen-activated protein kinase kinase kinase binding and SMAD binding. An important paralog of this gene is ACVR1C.

UniProtKB/Swiss-Prot: TGFR2_HUMAN, P37173
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor,
TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1,
TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological
and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of
mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2
molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1
by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor
and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates
the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta
signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways

Gene Wiki entry for TGFBR2 (TGF beta receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGFBR2 gene promoter:
         SRY   Sox5   E2F   E2F-1   MyoD   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFBR2 promoter sequence
   Search Chromatin IP Primers for TGFBR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFBR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p22

TGFBR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFBR2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P030623:  view genomic region     (about GC identifiers)

Start:
30,647,994 bp from pter      End:
30,735,634 bp from pter
Size:
87,641 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGFR2_HUMAN, P37173 (See protein sequence)
Recommended Name: TGF-beta receptor type-2 precursor  
Size: 567 amino acids; 64568 Da
Cofactor: Magnesium or manganese (By similarity)
Subunit: Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor
composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity
of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the
different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4.
Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with and is activated
by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is
independent of the receptor kinase activity and of the presence of TGF-beta
5 PDB 3D structures from and Proteopedia for TGFBR2:
1KTZ (3D)        1M9Z (3D)        1PLO (3D)        2PJY (3D)        3KFD (3D)    
Secondary accessions: B4DTV5 Q15580 Q6DKT6 Q99474
Alternative splicing: 2 isoforms:  P37173-1   P37173-2   

Explore the universe of human proteins at neXtProt for TGFBR2: NX_P37173

Explore proteomics data for TGFBR2 at MOPED

Post-translational modifications: 

  • Phosphorylated on a Ser/Thr residue in the cytoplasmic domain1
  • Glycosylation2 at Thr39, Asn70, Asn94, Asn154
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TGFBR2 (P37173) (see all 14)
     VKNDLTC  WLITAFH  VAVKIFP  LCKFCDV 


    See TGFBR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020018.1  NP_003233.4  

    ENSEMBL proteins: 
     ENSP00000295754   ENSP00000351905  
    Reactome Protein details: P37173

    TGFBR2 Human Recombinant Protein Products:

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    OriGene Purified Protein for TGFBR2
    OriGene Protein Over-expression Lysate for TGFBR2
    OriGene MassSpec for TGFBR2
    OriGene Custom Protein Services for TGFBR2
    GenScript Custom Purified and Recombinant Proteins Services for TGFBR2
    Novus Biologicals TGFBR2 Proteins
    Novus Biologicals TGFBR2 Lysate
    Sino Biological Recombinant Protein for TGFBR2
    Sino Biological Cell Lysate for TGFBR2
    ProSpec Recombinant Protein for TGFBR2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TGFBR2 

    TGFBR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TGFBR2
    R&D Systems Antibodies for TGFBR2 (TGF-beta RII)
    Cell Signaling Technology (CST) Antibodies for TGFBR2 
    OriGene Antibodies for TGFBR2
    OriGene Custom Antibody Services for TGFBR2
    Novus Biologicals TGFBR2 Antibodies
    Abcam antibodies for TGFBR2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TGFBR2
    LSBio Antibodies in human, mouse, rat for TGFBR2

    TGFBR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGFBR2
    R&D Systems ELISAs for TGFBR2 (TGF-beta RII)
    GenScript Custom Assay Services for TGFBR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TGFBR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: transforming growth factor, beta receptor II (70/80kDa)
    Type II receptor serine/threonine kinases
    Type II subfamily

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR015013 Transforming_GF_b_rcpt_2_ecto

    Graphical View of Domain Structure for InterPro Entry P37173

    ProtoNet protein and cluster: P37173

    1 Blocks protein domain: IPB000472 Domain in TGF-beta receptor/activin receptor

    UniProtKB/Swiss-Prot: TGFR2_HUMAN, P37173
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TGFBR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFR2_HUMAN, P37173
    Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor,
    TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1,
    TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological
    and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of
    mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production,
    immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2
    molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1
    by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor
    and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates
    the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta
    signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways
    Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

         Genatlas biochemistry entry for TGFBR2:
    transforming growth factor beta,receptor type II,75kDa,activating MADH2 and MADH3 (see TSG3B),often altered during
    adenoma-carcinoma progression of HNPCC,also prevalently mutated in the squamous cell carcinoma of head and
    neck,in pancreatic adenocarcinomas,in hepatocellular carcinoma,and in sporadic gastric cancer,inactivated in
    pancreatic and biliary cancers and in thyroid carcinoma,major target of the EWSR1/FLI1 chimeric oncoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.301 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004675transmembrane receptor protein serine/threonine kinase activity IDA12015308
    GO:0004702receptor signaling protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with TGFBR2           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TGFBR2:
     Decreased mitotic index  Decreased substrate adherent c  Gemcitabine induced cell-death  Increased apoptosis 
     Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 10 alleles(MGI details for Tgfbr2) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with TGFBR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TGFBR2: Tgfbr2tm1.1Hlm Tgfbr2tm1Mmt Tgfbr2tm1Sjkm Tgfbr2tm1.1Karl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFBR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFBR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGFBR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGFBR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TGFBR2:
    hsa-mir-335-5p (MIRT016729), hsa-mir-93-5p (MIRT027974), hsa-mir-590-5p (MIRT004619), hsa-mir-92a-3p (MIRT004737), hsa-mir-18a-5p (MIRT004592), hsa-mir-302b-3p (MIRT005930), hsa-mir-372-3p (MIRT005931), hsa-mir-19a-3p (MIRT004593), hsa-mir-20a-5p (MIRT001785), hsa-mir-17-5p (MIRT004591), hsa-mir-19b-3p (MIRT004594), hsa-mir-204-5p (MIRT003272), hsa-mir-130b-3p (MIRT020143), hsa-mir-21-5p (MIRT001189)

    Block miRNA regulation of human, mouse, rat TGFBR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFBR2 (see all 99):
    hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidTGFBR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TGFBR2
    Predesigned siRNA for gene silencing in human, mouse, rat TGFBR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGFBR2

    Clone
    Products:
         
    OriGene clones in human, mouse for TGFBR2 (see all 15)
    OriGene ORF clones in mouse, rat for TGFBR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFBR2 (NM_001024847)
    Sino Biological Human cDNA Clone for TGFBR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFBR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFBR2
    Addgene plasmids for TGFBR2 

    Cell Line
    Products:
         
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFBR2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12207) for TGFBR2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGFR2_HUMAN, P37173: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    extracellular2
    mitochondrion2
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ----
    GO:0005901caveola IDA17878231

    Find genes that share ontologies with TGFBR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TGFBR2 About   (see all 51)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    3Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47
    4Apoptosis Pathway
    Apoptosis Pathway0.45
    Akt Pathway0.39
    NF-kappaB Pathway0.45
    5TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.82
    TGF-beta receptor signaling activates SMADs0.82


    Find genes that share SuperPaths with TGFBR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for TGFBR2
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TGFBR2 (see all 16)
        PKA Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    TOB in T-Cell Signaling
    TGF-Beta Pathway

    1 Cell Signaling Technology (CST) Pathway for TGFBR2
        TGF-beta/Smad Signaling

    4 Tocris Bioscience Pathways for TGFBR2
        Akt Pathway
    Apoptosis Pathway
    TGF-beta Pathway
    NF-kappaB Pathway

    Selected GeneGo (Thomson Reuters) Pathways for TGFBR2 (see all 6)
        Transcription Androgen Receptor nuclear signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell adhesion Plasmin signaling
    Cytokine production by Th17 cells in CF (Mouse model)
    Translation Regulation of EIF4F activity

    Selected BioSystems Pathways for TGFBR2 (see all 8)
        MAPK signaling pathway
    TGF Beta Signaling Pathway
    Integrated Breast Cancer Pathway
    TGF-beta Receptor Signaling Pathway
    Glypican 1 network

    1 Sino Biological Pathway for TGFBR2
        TGF-beta Signaling Pathway

    Selected Reactome Pathways for TGFBR2 (see all 8)
        TGF-beta receptor signaling activates SMADs
    TGFBR2 Kinase Domain Mutants in Cancer
    SMAD2/3 MH2 Domain Mutants in Cancer
    TGFBR1 LBD Mutants in Cancer
    TGFBR1 KD Mutants in Cancer


    Selected Kegg Pathways  (Kegg details for TGFBR2) (see all 15):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    FoxO signaling pathway
    Endocytosis
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFBR2 (see all 7): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TGFBR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGFBR2 (P371731, 2, 3 ENSP000003519054) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB3P106001, 2, 3, ENSP000002386824EBI-296151,EBI-1033020 MINT-8182884 MINT-8182908 MINT-8183771 MINT-8182846 MINT-8182828 MINT-8182931 MINT-8182809 I2D: score=6 STRING: ENSP00000238682
    ENSG00000227046Q9UER71, 3, ENSP000004107724EBI-296151,EBI-77321 I2D: score=2 STRING: ENSP00000410772
    ENSG00000206206Q9UER71, 3EBI-296151,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-296151,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-296151,EBI-77321 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 62):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development TAS10092230
    GO:0001569patterning of blood vessels ISS--
    GO:0001570vasculogenesis ISS--
    GO:0001701in utero embryonic development IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--

    Find genes that share ontologies with TGFBR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGFBR2 (TGFR2)

    4 HMDB Compounds for TGFBR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    1 DrugBank Compound for TGFBR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycerol-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for TGFBR2 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mononucleotide 85.8 44 10690536 (4), 10699890 (2), 17950544 (2), 9500552 (1) (see all 30)
    taad 84.4 15 16027248 (4), 19542084 (2), 16791849 (1), 16646045 (1) (see all 7)
    tgf beta1 76.1 36 17763417 (4), 10208456 (3), 19688145 (3), 11531253 (2) (see all 19)
    threonine 60.3 20 11212236 (2), 10789724 (2), 1310899 (1), 1525823 (1) (see all 17)
    serine 49 20 11212236 (2), 10789724 (2), 1310899 (1), 1525823 (1) (see all 17)
    crcs 39 4 17893910 (2), 10544223 (1), 20026115 (1)
    eb 1089 35.5 1 10613355 (1)
    adenylate 27.8 20 12546068 (3), 11253131 (2), 10928062 (2), 9850059 (1) (see all 9)
    polynucleotide 26.9 3 9808530 (1), 9468559 (1)
    5-aza-2'deoxycytidine 23.9 5 9632722 (1), 11507078 (1), 16163707 (1)



    Find genes that share compounds with TGFBR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TGFBR2 gene (2 alternative transcripts): 
    NM_001024847.2  NM_003242.5  

    Unigene Cluster for TGFBR2:

    Transforming growth factor, beta receptor II (70/80kDa)
    Hs.82028  [show with all ESTs]
    Unigene Representative Sequence: BX648313
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295754(uc021wut.1 uc003cen.3 uc003ceo.3) ENST00000359013

    miRNA
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    Block miRNA regulation of human, mouse, rat TGFBR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFBR2 (see all 99):
    hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-1244 hsa-miR-93 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidTGFBR2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): TGFBR2 (NM_001024847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFBR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFBR2
    Addgene plasmids for TGFBR2 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12207) for TGFBR2 

    Additional mRNA sequence: 

    AJ786388.1 AK300383.1 AK304404.1 AK314102.1 BC040499.1 BX648313.1 D28131.1 M85079.1 

    10 DOTS entries:

    DT.453682  DT.100028901  DT.91829754  DT.95260870  DT.100795703  DT.92437549  DT.120891788  DT.91981415 
    DT.95149729  DT.99993512 

    Selected AceView cDNA sequences (see all 387):

    AI185412 AI346014 BM674218 BM992859 BQ898216 H01473 AI148760 BQ888787 
    BQ882217 CA421026 AL710460 AI146295 CD518135 AA347356 CA418314 BM839463 
    AA147023 AI673468 BI770594 BU683312 AA486678 BQ030167 BU625110 BX283766 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TGFBR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:              -                       -                                 
    SP2:                                                                        
    SP3:                                                                        


    ECgene alternative splicing isoforms for TGFBR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TGFBR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TGFBR2 Expression
    About this image


    TGFBR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Rib
     
     Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
             Prechondrocytic Mesenchymal Cells Annulus Fibrosus
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
    TGFBR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGFBR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82028
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFBR2 (see all 7): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Stem Cell Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TGFBR2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfbr21 , 5 transforming growth factor, beta receptor II1, 5 87.22(n)1
    91.39(a)1
      9 (68.39 cM)5
    218131  NM_009371.31  NP_033397.31 
     1160876985 
    chicken
    (Gallus gallus)
    Aves TGFBR21 transforming growth factor, beta receptor II (70/8 more 73.68(n)
    78.97(a)
      396399  NM_205428.1  NP_990759.1 
    lizard
    (Anolis carolinensis)
    Reptilia TGFBR26
    transforming growth factor, beta receptor II (70/8...
    74(a)
    1 ↔ 1
    1(194651238-194711939)
    African clawed frog
    (Xenopus laevis)
    Amphibia tgfbr2-A2 transforming growth factor, beta receptor II 76.56(n)    AF213685.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tgfbr22 transforming growth factor, beta receptor II 78.39(n)   30739  AY178449.1 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-43 Expression: alimentary system, amphid
    neurons, more
    37(a)   III(5696920-5703621)   --


    ENSEMBL Gene Tree for TGFBR2 (if available)
    TreeFam Gene Tree for TGFBR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TGFBR2 gene
    ACVR1C2  AMHR22  ACVR2B2  ACVR2A2  TGFBR12  ACVR1B2  BMPR1A2  ACVR12  
    BMPR22  ACVRL12  BMPR1B2  
    9 SIMAP similar genes for TGFBR2 using alignment to 3 protein entries:     TGFR2_HUMAN (see all proteins):
    H_YH98E06.1    ACVR2B    ACVR2A    TGFBR1    ACVR1B    ACVR1C
    BMPR1A    BMPR1B    BMPR2

    Find genes that share paralogs with TGFBR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGFBR2 (see all 2041)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289345681,2,,4
    CLoeys-Dietz syndrome 2B (LDS2B)4 pathogenic130651864(+) GTTCCC/TGACGG 4 P L mis1 ese30--------
    rs348338121,2,,4
    CHereditary non-polyposis colorectal cancer 6 (HNPCC6)4 pathogenic130651885(+) GAAGAC/TGGAGT 4 T M mis12Minor allele frequency- T:0.00NA 4
    rs357666121,2,,4
    C,FA breast tumor4 unknown130652100(+) TCCTCA/G/TTGAAG 4 V L mis15NA NS EU 6922
    VAR_0223534
    Loeys-Dietz syndrome 1B (LDS1B)4--see VAR_0223532 A P mis40--------
    VAR_0360704
    A colorectal cancer sample4--see VAR_0360702 I V mis40--------
    VAR_0414154
    A lung neuroendocrine carcinoma sample4--see VAR_0414152 H Y mis40--------
    VAR_0667274
    Loeys-Dietz syndrome 1B (LDS1B)4--see VAR_0667272 G V mis40--------
    VAR_0297604
    Loeys-Dietz syndrome 2B (LDS2B)4--see VAR_0297602 R C mis40--------
    VAR_0297614
    Loeys-Dietz syndrome 2B (LDS2B)4--see VAR_0297612 R H mis40--------
    VAR_0667314
    Loeys-Dietz syndrome 1B (LDS1B)4--see VAR_0667312 W R mis40--------

    HapMap Linkage Disequilibrium report for TGFBR2 (30647994 - 30735634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TGFBR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3748CNV Insertion18451855
    nsv876665CNV Gain21882294
    nsv876664CNV Gain21882294
    nsv7352OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TGFBR2
    Locus Specific Mutation Databases (LSDB): TGFBR2

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TGFBR2:
    Birth Defects
    SeqTarget long-range PCR primers for resequencing TGFBR2
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFBR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190182   
    OMIM disorders: 614331  133239  610168  
    UniProtKB/Swiss-Prot: TGFR2_HUMAN, P37173
  • Hereditary non-polyposis colorectal cancer 6 (HNPCC6) [MIM:614331]: An autosomal dominant disease
    associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to
    early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female
    reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western
    world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary
    predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II
    is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach,
    small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the
    Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other
    two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of
    hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families
    who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is
    strongly suspected. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Loeys-Dietz syndrome 1B (LDS1B) [MIM:610168]: An aortic aneurysm syndrome with widespread systemic
    involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism,
    and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain
    abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm
    with dissection throughout the arterial tree. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Loeys-Dietz syndrome 2B (LDS2B) [MIM:610380]: An aortic aneurysm syndrome with widespread systemic
    involvement. Physical findings include diffuse arterial aneurysms and dissections, prominent joint laxity, easy
    bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of
    the spleen or bowel, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the
    arteries, either during pregnancy or in the immediate postpartum period. Loeys-Dietz syndrome type 2 is
    characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present
    in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry. TGFBR2
    mutations Cys-460 and His-460 have been reported to be associated with thoracic aortic aneurysms and dissection
    (TAAD). This phenotype, also known as thoracic aortic aneurysms type 3 (AAT3), is distinguised from LDS2B by
    having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit descending
    aortic disease and aneurysms of other arteries (PubMed:16027248), they have been considered as LDS2B by the OMIM
    resource

  • Selected diseases for TGFBR2 (see all 29):    
    About MalaCards
    loeys-dietz syndrome    aneurysm    tgfbr2-related loeys-dietz syndrome    loeys-dietz syndrome, type 2
    loeys-dietz syndrome type 1b    esophageal cancer    thoracic aortic aneurysms and aortic dissections    colorectal cancer, hereditary nonpolyposis, type 6
    tgfbr2-related thoracic aortic aneurysms and aortic dissections    intracranial hypotension    aortic aneurysm    colorectal cancer 6
    esophageal cancer, somatic    microcystic adenoma    esophageal squamous cell carcinoma    loeys-dietz syndrome, type 1
    esophageal squamous cell carcinoma, somatic    transient hypogammaglobulinemia of infancy    chromosome 3p deletion    marfan syndrome

    6 diseases from the University of Copenhagen DISEASES database for TGFBR2:
    Loeys-Dietz syndrome     Lynch syndrome     Carcinoma     Colorectal cancer
    Cleft palate     Aortic aneurysm

    Find genes that share disorders with TGFBR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TGFBR2 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 90.9 105 9330602 (3), 16635398 (3), 11751500 (2), 8900429 (2) (see all 69)
    marfan syndrome 72.4 40 15235604 (2), 19533785 (2), 18781618 (2), 16799921 (2) (see all 22)
    colorectal cancer 66.7 81 10690536 (5), 8978340 (4), 17270239 (4), 11159190 (2) (see all 43)
    gastric cancer 61.9 58 12324709 (5), 9230189 (4), 17562261 (4), 17187359 (4) (see all 27)
    colon cancer 61.5 51 16108056 (5), 17985359 (5), 14714614 (2), 20026115 (2) (see all 18)
    aortic aneurysm thoracic 61 10 19542084 (2), 16791849 (1), 18264665 (1), 16027248 (1) (see all 8)
    tumors 60.9 227 11405868 (7), 12825850 (5), 9721065 (3), 16380996 (3) (see all 99)
    cancer 55.2 95 9458298 (3), 9566701 (3), 11253131 (2), 8952554 (2) (see all 59)
    gastric carcinoma 49.4 27 19624886 (3), 9538129 (2), 12692838 (2), 8840981 (2) (see all 14)
    colorectal carcinoma 47.9 18 11319759 (2), 9330602 (2), 8952554 (2), 11212236 (1) (see all 8)

    GeneTests: TGFBR2
    GeneReviews: TGFBR2
    Genetic Association Database (GAD): TGFBR2
    Human Genome Epidemiology (HuGE) Navigator: TGFBR2 (57 documents)

    Export disorders for TGFBR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGFBR2 gene, integrated from 10 sources (see all 944):
    (articles sorted by number of sources associating them with TGFBR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterozygous TGFBR2 mutations in Marfan syndrome. (PubMed id 15235604)1, 2, 3, 9 Mizuguchi T....Matsumoto N. (Nat. Genet. 2004)
    2. A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway. (PubMed id 12202987)1, 2, 4, 9 Watanabe Y.... Yoshiura K. (J. Hum. Genet. 2002)
    3. TGFBR2 gene expression and genetic association with schizophrenia. (PubMed id 17560608)1, 4, 9 Numata S....Ohmori T. (J Psychiatr Res 2008)
    4. Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. (PubMed id 19542084)1, 4, 9 Tran-Fadulu V....Milewicz D.M. (J. Med. Genet. 2009)
    5. TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. (PubMed id 17270239)1, 4, 9 Ogino S....Fuchs C.S. (Hum. Pathol. 2007)
    6. Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. (PubMed id 17187359)1, 4, 9 Jin G....Shen H. (Int. J. Cancer 2007)
    7. Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. (PubMed id 16027248)1, 2, 9 Pannu H.... Milewicz D.M. (Circulation 2005)
    8. TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population. (PubMed id 17680270)1, 4, 9 Jin G....Shen H. (J. Cancer Res. Clin. Oncol. 2008)
    9. A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. (PubMed id 10789724)1, 2, 9 Tanaka S.... Sugimachi K. (Br. J. Cancer 2000)
    10. Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients. (PubMed id 19883511)1, 2, 9 Drera B.... Colombi M. (Orphanet J. Rare Dis. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7048 HGNC: 11773 AceView: TGFBR2 Ensembl:ENSG00000163513 euGenes: HUgn7048
    ECgene: TGFBR2 Kegg: 7048 H-InvDB: TGFBR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGFBR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFBR2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TGFBR2[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgfbr2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGFBR2 gene:
    Search GeneIP for patents involving TGFBR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse Proteins at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TGFBR2
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     SwitchGear 3'UTR luciferase reporter plasmids for TGFBR2
     SwitchGear Promoter luciferase reporter plasmids for TGFBR2
     ThermoFisher Antibodies for TGFBR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFBR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFBR2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFBR2
     LSBio Antibodies in human, mouse, rat for TGFBR2
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
     Addgene plasmids for TGFBR2
      Search eBioscience for proteins for TGFBR2
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      eBioscience FlowRNA Probe Sets
           
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