Aliases for TGFBI Gene
External Ids for TGFBI Gene
Previous Symbols for TGFBI Gene
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
GeneCards Summary for TGFBI Gene
TGFBI (Transforming Growth Factor, Beta-Induced, 68kDa) is a Protein Coding gene. Diseases associated with TGFBI include corneal dystrophy, reis-bucklers type and corneal dystrophy, epithelial basement membrane. Among its related pathways are Disease and RNA Polymerase I Promoter Opening. GO annotations related to this gene include integrin binding and extracellular matrix binding. An important paralog of this gene is POSTN.
UniProtKB/Swiss-Prot for TGFBI Gene
Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation