Aliases for TGFB2 Gene
External Ids for TGFB2 Gene
Previous GeneCards Identifiers for TGFB2 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
GeneCards Summary for TGFB2 Gene
TGFB2 (Transforming Growth Factor Beta 2) is a Protein Coding gene. Diseases associated with TGFB2 include Loeys-Dietz Syndrome 4 and Tgfb2-Related Loeys-Dietz Syndrome. Among its related pathways are Regulation of retinoblastoma protein and HTLV-I infection. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is TGFB3.
UniProtKB/Swiss-Prot for TGFB2 Gene
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.