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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGFB2 Gene

protein-coding   GIFtS: 67
GCID: GC01P218519

transforming growth factor, beta 2
 Explore 169 diseases affiliated with
TGFB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TGFB2    

Aliases
for TGFB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transforming Growth Factor, Beta 21 2     Cetermin3
Glioblastoma-Derived T-Cell Suppressor Factor2 3     Polyergin3
G-TSF2 3     Transforming Growth Factor Beta-22
BSC-1 Cell Growth Inhibitor2 3     Cetermin3
LDS42     Polyergin3
TGF-Beta21     TGF-Beta-21

External Ids:    HGNC: 117681   Entrez Gene: 70422   Ensembl: ENSG000000929697   OMIM: 1902205   UniProtKB: P618123   

Export aliases for TGFB2 gene to outside databases

Previous GC identifers: GC01P217194 GC01P214364 GC01P215122 GC01P215576 GC01P214908 GC01P216586 GC01P189187


Summaries
for TGFB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TGFB2:
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional
peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by
transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and
their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of
human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth.
Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of
the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of
developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have
been identified. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

Gene Wiki entry for TGFB2 (TGF beta 2)


Genomic Views
for TGFB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGFB2 gene promoter:
         GR   C/EBPbeta   p53   AP-1   GR-beta   ATF-2   CREB   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TGFB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGFB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

TGFB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P218519:  view genomic region     (about GC identifiers)

Start:
 218,519,391 bp from pter      End:
 218,617,961 bp from pter
Size:
 98,571 bases      Orientation:
 plus strand

Proteins
for TGFB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812 (See protein sequence)
Recommended Name: Transforming growth factor beta-2 precursor  
Size: 414 amino acids; 47748 Da
Subunit: Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in bone
(By similarity). Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Interacts with ASPN
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for TGFB2:
1TFG (3D)        2TGI (3D)    
Secondary accessions: B4DKC5 P08112 Q15579 Q15581 Q4VAV9
Alternative splicing: 2 isoforms:  P61812-1, P08112-1   P61812-2, P08112-2   

Explore the universe of human proteins at neXtProt for TGFB2: NX_P61812

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61812

    • TGFB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129071.1  NP_003229.1  

    ENSEMBL proteins: 
     ENSP00000355897   ENSP00000355896  
    Reactome Protein details: P61812
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant TGFB2 Protein
    R&D Systems Recombinant & Natural Proteins for TGFB2 (TGF-beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TGFB2
    OriGene Protein Over-expression Lysate (see all 2): TGFB2
    OriGene Custom Protein Services for TGFB2 
    GenScript Custom Purified and Recombinant Proteins Services for TGFB2
    Novus Biologicals TGFB2 Proteins
    Novus Biologicals TGFB2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TGFB2
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane ----
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005802trans-Golgi network ----


    TGFB2 for ontologies           About GeneDecksing



    TGFB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TGFB2
    R&D Systems Antibodies for TGFB2 (TGF-beta 2/1.2, TGF-beta 2)
    Cell Signaling Technology (CST) Antibodies for TGFB2 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TGFB2 
    GenScript Custom Superior Antibodies Services for TGFB2
    Novus Biologicals TGFB2 Antibodies
    Search for Antibodies for TGFB2 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for TGFB2

    Assay Products for TGFB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for TGFB2 (TGF-beta 2)         (see all)
    GenScript Custom Assay Services for TGFB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TGFB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TGFB2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR016319 TGF-beta
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P61812

    ProtoNet protein and cluster: P61812

    5 Blocks protein families:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB003911 Transforming growth factor beta precursor signature
    IPB003940 Transforming growth factor beta 2 precursor signature


    UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
    Similarity: Belongs to the TGF-beta family


    Function
    for TGFB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
    Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

         Genatlas biochemistry entry for TGFB2:
    transforming growth factor,beta 2,152.6kDa,homodimerizing,expressed by
    fibroblast,platelet,monocyte,chondrocyte,osteoblasts,including the latency associated peptide (LAP),inhibitor of
    epithelial cell growth and inductor of extracellular matrix formation

         Summary:  
    During embryonic development, TGFB2 as signaling molecule is secreted from the following cells: Early Tenocyte Cells in Limb Tendon Primordia, GABAergic Amacrine Cells in Inner Nuclear Layer (see all 11).

    It affects the following cells: Early Retinal Progenitor Cells in Neuroblastic Layer, Early Tenocyte Cells in Axial Tendon Primordia (see all 6).

    miRNA
    Products:            		miRTarBase miRNAs that target TGFB2:
    hsa-mir-141 (MIRT002285)

    OriGene 3'-UTR Clone (see all 2): TGFB2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGFB2
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate TGFB2 (see all 105):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-4305 hsa-miR-1245 hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: TGFB2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGFB2 (see all 7)
    OriGene shRNA RFP: TGFB2
    OriGene siRNA: TGFB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGFB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TGFB2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGFB2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGFB2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFB2 (NM_003238)
    Sino Biological Human cDNA Clone for TGFB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TGFB2
    Search LifeMap BioReagents cell lines for TGFB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB2

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IDA16227582
    GO:0004702receptor signaling protein serine/threonine kinase activity IDA12958365
    GO:0005102receptor binding IMP16227582
    GO:0005114type II transforming growth factor beta receptor binding IPI1333888
    GO:0005125cytokine activity TAS9611771


    TGFB2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TGFB2:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Tgfb2tm1Doe for TGFB2
         15/19 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tgfb2) (see all 19):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  muscle  nervous system  renal/urinary system 

    TGFB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TGFB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/57 super-pathways (see all 57) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TGFB2
        Cell cycle Regulation of G1/S transition (part 1)
    Cell adhesion Plasmin signaling

    5/6 R&D Systems Pathways for TGFB2 (see all 6)
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation
    TGF-beta Signaling Pathways

    5/68 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TGFB2 (see all 68)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for TGFB2
        Angiogenesis
    TGF-beta/Smad Signaling

    2 GeneGo (Thomson Reuters) Pathways for TGFB2
        Cell cycle Regulation of G1/S transition (part 1)
    Cell adhesion Plasmin signaling

    5/7 BioSystems Pathways for TGFB2 (see all 7) 
        p38 MAPK Signaling Pathway
    MAPK signaling pathway
    TGF-beta Receptor Signaling Pathway
    Endochondral Ossification
    Signaling events mediated by the Hedgehog family

    5/7        Reactome Pathways for TGFB2 (see all 7)
        Hemostasis
    Molecules associated with elastic fibres
    Extracellular matrix organization
    Platelet degranulation
    Elastic fibre formation


    5/20         Kegg Pathways  (Kegg details for TGFB2) (see all 20):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Cell cycle
    Endocytosis
    TGF-beta signaling pathway


    TGFB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGFB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for TGFB2 (P618121, 3 ENSP000003558964) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050671, 3, ENSP000002849814EBI-779581,EBI-77613 I2D: score=3 STRING: ENSP00000284981
    TGFB1P011373, ENSP000002219304I2D: score=2 STRING: ENSP00000221930
    TGFBR2P371733, ENSP000003519054I2D: score=2 STRING: ENSP00000351905
    TGFBR3Q031673, ENSP000002123554I2D: score=2 STRING: ENSP00000212355
    VASNQ6EMK43, ENSP000003068644I2D: score=2 STRING: ENSP00000306864
    About this table

    Gene Ontology (GO): 5/106 biological process terms (GO ID links to tree view) (see all 106):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IDA15896309
    GO:0001501skeletal system development ----
    GO:0001502cartilage condensation IEA--
    GO:0001525angiogenesis TAS9611771
    GO:0001568blood vessel development ----


    TGFB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TGFB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGFB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TGFB2
    10/74 Novoseek chemical compound relationships for TGFB2 gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 81.8 95 15057430 (7), 11453034 (6), 17270215 (6), 11514049 (6) (see all 43)
    vegf 51.6 94 14620032 (6), 19085381 (6), 17331500 (5), 11642726 (4) (see all 38)
    4-hydroxytamoxifen 40.9 3 18043895 (1), 1834933 (1), 8143893 (1)
    ribonucleic acid 40 5 7962292 (1), 8013382 (1), 1280203 (1)
    epsilon-(gamma-glutamyl)lysine 38.4 1 16936095 (1)
    thymidine 37.7 8 16481045 (1), 16402924 (1), 2270434 (1), 8013384 (1) (see all 7)
    retinoic acid 34.6 55 9153223 (5), 15609095 (5), 8603400 (4), 15955085 (4) (see all 15)
    rantes 32.9 7 16249505 (1), 11884483 (1), 12975472 (1), 11342433 (1) (see all 7)
    pge2 27.2 25 10807250 (3), 16400016 (3), 9704780 (3), 14749055 (2) (see all 9)
    indoleamine 25.6 1 17565341 (1)

    Search CenterWatch for drugs/clinical trials and news about TGFB2 

    Transcripts
    for TGFB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TGFB2 gene (2 alternative transcripts): 
    NM_001135599.2  NM_003238.3  

    Unigene Cluster for TGFB2:

    Transforming growth factor, beta 2
    Hs.133379  [show with all ESTs]
    Unigene Representative Sequence: NM_001135599
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366930(uc001hlm.3 uc001hlo.3) ENST00000366929(uc001hll.3 uc001hln.3 uc010pue.2)
    ENST00000488793 ENST00000479322

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TGFB2
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate TGFB2 (see all 105):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-4305 hsa-miR-1245 hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: TGFB2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGFB2 (see all 7)
    OriGene shRNA RFP: TGFB2
    OriGene siRNA: TGFB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGFB2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGFB2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGFB2 (see all 2)
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    GenScript: all cDNA clones in your preferred vector (see all 2): TGFB2 (NM_003238)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGFB2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGFB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGFB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFB2

    Additional cDNA sequence: 

    AK021874.1 AK296504.1 AK313106.1 BC096235.4 BC099635.1 BC099636.1 M19154.1 Y00083.1 

    5 DOTS entries:

    DT.97807399  DT.213595  DT.100745830  DT.86850114  DT.97826963 

    24/126 AceView cDNA sequences (see all 126):

    BF445951 BM721214 AI276277 AA327931 BQ440511 BM723925 AI468404 AI247406 
    BF061658 AL697807 CA312162 AA233738 M19154 AI090617 AI074048 BF732315 
    BG194286 AW173038 AL700929 BX370126 N48082 BF109964 AL700027 BX339694 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TGFB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                          -                                 
    SP2:        -                 -                                 
    SP3:        -                 -           -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for TGFB2

    Expression
    for TGFB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGFB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTAAAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TGFB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/43 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 43) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Tendons & LigamentsAxial Tendon PrimordiaEarly Tenocyte CellsTendons & Ligaments
    Tendons & LigamentsAxial Tendons and LigamnetsTenocytesTendons & Ligaments
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCervical VertebraeChondrocytesBone, Cartilage
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneCervical VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneCervical VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneFacial SuturesFacial Fusing Suture CellsBone
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneLumbar VertebraeHypertrophic ChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13) 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See TGFB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGFB2

    SOURCE GeneReport for Unigene cluster: Hs.133379
        SABiosciences Expression via Pathway-Focused PCR Arrays including TGFB2 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGFB2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFB2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB2

    Orthologs
    for TGFB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TGFB2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TGFB21 transforming growth factor, beta 2 85.52(n)
    90.78(a)    		   421352  XM_003640970.1  XP_003641018.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 86(a)
    82(a)
    		 possible ortholog
    possible ortholog
    		 1(242487137-242487448)
    1(242606270-242630524)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tgfb2-A2 transforming growth factor, beta 2 79.18(n)    X51817.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tgfb22 transforming growth factor, beta 2 75.02(n)   369194  AY338730.1 


    ENSEMBL Gene Tree for TGFB2 (if available)
    TreeFam Gene Tree for TGFB2 (if available) 

    Paralogs
    for TGFB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGFB2 gene
    TGFB32  INHBC2  GDF112  MSTN2  INHBE2  INHBA2  TGFB12  INHBB2  
    2 SIMAP similar genes for TGFB2 using alignment to 1 protein entry:     TGFB2_HUMAN:
    TGFB3    TGFB1

    TGFB2 for paralogs           About GeneDecksing



    Genomic Variants
    for TGFB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1757 NCBI SNPs in TGFB2 are shown (see all 1757)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs66910701,2
    		C,F,A,H,--189184929(+) NNNNCA/GGTGAT 2 -- us2k110Minor allele frequency- G:0.14NS EA WA CSA NA 781
    rs1125576001,2
    		C,--189185139(+) TAGCGC/ACTCTT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs789797601,2
    		C,F,--189185317(+) AAAATT/CCTGTA 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs114663631,2
    		C,--189186980(+) AAGAGG/ACAGGG 2 -- ut514Minor allele frequency- A:0.02NA EU WA 212
    rs114663651,2
    		C,F,--189187194(+) ACCCCC/TTCAGG 2 -- ut514Minor allele frequency- T:0.04NA EU WA 212
    rs731103101,2
    		C,--189187496(+) CGAGTA/CCCGAG 2 -- ut512Minor allele frequency- C:0.32WA 120
    rs1123692311,2
    		C,--189187533(+) CGCGGT/CGCGCT 2 -- ut514Minor allele frequency- C:0.39CSA WA NA EA 359
    rs1137115401,2
    		C,--189188095(+) ATCAAAAAC/-  
                AAACA     		2 -- ut511Minor allele frequency- -:0.00CSA 2
    rs114663671,2
    		F--189188098(+) AAAAACAAA/-  
                CAACA     		2 -- ut513Minor allele frequency- -:0.49NA EU 90
    rs170267381,2
    		F--189188099(+) AAAAC-/AAAC  
                AACAA     		2 -- ut512Minor allele frequency- AAAC:0.28MN EA 356

    HapMap Linkage Disequilibrium report for TGFB2 (218519391 - 218617961 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TGFB2: --
    Human Gene Mutation Database (HGMD): TGFB2

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing TGFB2:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGFB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFB2

    Disorders / Diseases
    for TGFB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TGFB2 for disorders           About GeneDecksing

    OMIM gene information: 190220    OMIM disorders: --

    UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
  • Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation
    • t(1;7)(q41;p21) with HDAC9
  • Defects in TGFB2 are the cause of Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]. An aortic aneurysm syndrome with
    • widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial
    aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve,
    arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising
    and striae

    20/169 diseases for TGFB2 (see all 169):    About MalaCards
    peters anomaly    open-angle glaucoma    angle-closure glaucoma    primary open angle glaucoma
    spinal cord injury    seborrheic keratosis    glioblastoma    macular holes
    cleft lip/palate    proliferative diabetic retinopathy    bullous keratopathy    osteoporosis, postmenopausal
    otitis media    graft versus host disease    non-small cell lung carcinoma    glaucoma
    diabetic retinopathy    multinodular goiter    hereditary hemorrhagic telangiectasia    cleft lip

    4 diseases from the University of Copenhagen DISEASES database for TGFB2:
    Macular holes     Glaucoma     Proliferative vitreoretinopathy     Malignant glioma

    10/95 Novoseek disease relationships for TGFB2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitreoretinopathy proliferative 68.1 4 1800167 (1), 15505063 (1), 18253093 (1)
    aqueous humor 67.3 59 17167403 (7), 17278530 (3), 12484701 (2), 19959644 (2) (see all 27)
    macular holes 63.1 41 9544645 (7), 7825689 (4), 8956640 (3), 9098285 (2) (see all 16)
    fuchs heterochromic cyclitis 59.4 1 16249505 (1)
    breast cysts 56.6 4 7852541 (2), 10652596 (1), 18181041 (1)
    glioma 53.8 46 17453002 (5), 19033423 (4), 11331365 (3), 15072445 (3) (see all 19)
    malignant glioma 50.8 9 1874566 (2), 17638524 (2), 9488308 (1), 19465936 (1) (see all 7)
    glioblastoma 50.4 34 12017331 (6), 11776974 (4), 15072445 (3), 1315829 (2) (see all 15)
    conjunctival scarring 48.9 2 15652533 (1), 10476787 (1)
    glaucoma open-angle 47.4 16 17998032 (2), 17251470 (1), 15652533 (1), 11405069 (1) (see all 8)

    Genetic Association Database (GAD): TGFB2
    Human Genome Epidemiology (HuGE) Navigator: TGFB2 (37 documents)

    Export disorders for TGFB2 gene to outside databases

    Publications
    for TGFB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGFB2 gene, integrated from 9 sources (see all 826):
    (articles sorted by number of sources associating them with TGFB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transforming growth factor-12 polymorphism and systemic lupus erythematosus. (PubMed id 12064833)1, 4, 9 Alansari A....Ollier W. (2002)
    2. Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. (PubMed id 22772368)1, 2 Lindsay M.E....Loeys B.L. (2012)
    3. Mechanisms for asporin function and regulation in articular cartilage. (PubMed id 17827158)1, 2 Nakajima M.... Ikegawa S. (2007)
    4. Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease. (PubMed id 15009106)1, 4 Bayat A....Ferguson M.W. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly. (PubMed id 12706107)1, 2 David D....Boavida M.G. (2003)
    8. Genetic susceptibility in Dupuytren's disease: lack of association of a novel transforming growth factor beta(2) polymorphism in Dupuytren's disease. (PubMed id 11895345)1, 4 Bayat A....Ollier W.E. (2002)
    9. Polymorphisms of transforming growth factor-beta1 and transforming growth factor-beta1 type II receptor genes are associated with acute graft-versus-host disease in children with HLA-matched sibling bone marrow transplantation. (PubMed id 12420205)1, 4 Hattori H....Hara T. (2002)
    10. Two novel polymorphisms in the human transforming growth factor beta 2 gene. (PubMed id 11528528)1, 2 Alansari A.... Ollier W.E. (2001)

    External Searches for TGFB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TGFB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7042 HGNC: 11768 AceView: TGFB2 Ensembl:ENSG00000092969 euGenes: HUgn7042
    ECgene: TGFB2 Kegg: 7042 H-InvDB: TGFB2

    Other Databases showing TGFB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TGFB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGFB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgfb2/
    Wikipedia http://en.wikipedia.org/wiki/TGF_beta_2

    Intellectual Property
    for TGFB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TGFB2 gene:
    Search GeneIP for patents involving TGFB2

    Licensable Technologies for TGFB2 gene:
     Tufts University:  Use of miRNAs to selectively modulate TGF-?/BMP signaling to treat TGF-?/BMP mediated disorders
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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