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TGFB2 Gene

protein-coding   GIFtS: 70
GCID: GC01P218519

Transforming Growth Factor, Beta 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming Growth Factor, Beta 21 2     cetermin2
Prepro-Transforming Growth Factor Beta-21 2     polyergin2
Glioblastoma-Derived T-Cell Suppressor Factor2 3     Transforming Growth Factor Beta-22
G-TSF2 3     Cetermin3
BSC-1 Cell Growth Inhibitor2 3     Polyergin3
LDS42 5     TGF-beta-23
TGF-beta22     

External Ids:    HGNC: 117681   Entrez Gene: 70422   Ensembl: ENSG000000929697   OMIM: 1902205   UniProtKB: P618123   

Export aliases for TGFB2 gene to outside databases

Previous GC identifers: GC01P217194 GC01P214364 GC01P215122 GC01P215576 GC01P214908 GC01P216586 GC01P189187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGFB2 Gene:
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are
multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions
in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors
(TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has
been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of
interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated
with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene
show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced
transcript variants encoding different isoforms have been identified. (provided by RefSeq, Sep 2010)

GeneCards Summary for TGFB2 Gene:
TGFB2 (transforming growth factor, beta 2) is a protein-coding gene. Diseases associated with TGFB2 include loeys-dietz syndrome, type 4, and tgfb2-related loeys-dietz syndrome. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

Gene Wiki entry for TGFB2 (TGF beta 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGFB2 gene promoter:
         GR   C/EBPbeta   p53   AP-1   GR-beta   ATF-2   CREB   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TGFB2 promoter sequence
   Search Chromatin IP Primers for TGFB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

TGFB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P218519:  view genomic region     (about GC identifiers)

Start:
218,518,676 bp from pter      End:
218,617,961 bp from pter
Size:
99,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812 (See protein sequence)
Recommended Name: Transforming growth factor beta-2 precursor  
Size: 414 amino acids; 47748 Da
Subunit: Homodimer; disulfide-linked (By similarity). Heterodimers with TGFB1 and with TGFB3 have been found in
bone (By similarity). Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Latency-associated
peptide interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity).
Interacts with ASPN
2 PDB 3D structures from and Proteopedia for TGFB2:
1TFG (3D)        2TGI (3D)    
Secondary accessions: B4DKC5 P08112 Q15579 Q15581 Q4VAV9
Alternative splicing: 2 isoforms:  P61812-1, P08112-1   P61812-2, P08112-2   

Explore the universe of human proteins at neXtProt for TGFB2: NX_P61812

Explore proteomics data for TGFB2 at MOPED

Post-translational modifications: 

  • The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2
    rendering it inactive (By similarity)1
  • Glycosylation2 at Asn72, Asn140, Asn241
  • Modification sites at PhosphoSitePlus

  • See TGFB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129071.1  NP_003229.1  

    ENSEMBL proteins: 
     ENSP00000355897   ENSP00000355896  
    Reactome Protein details: P61812

    TGFB2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TGFB2 Protein
    R&D Systems Recombinant & Natural Proteins for TGFB2 (TGF-beta 2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TGFB2
    OriGene Protein Over-expression Lysate for TGFB2
    OriGene MassSpec for TGFB2
    OriGene Custom Protein Services for TGFB2
    GenScript Custom Purified and Recombinant Proteins Services for TGFB2
    Novus Biologicals TGFB2 Proteins
    Novus Biologicals TGFB2 Lysates
    Sino Biological Recombinant Protein for TGFB2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TGFB2
    Browse Proteins at Cloud-Clone Corp.

    TGFB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TGFB2
    R&D Systems Antibodies for TGFB2 (TGF-beta 2/1.2, TGF-beta 2)
    Cell Signaling Technology (CST) Antibodies for TGFB2 
    OriGene Antibodies for TGFB2
    OriGene Custom Antibody Services for TGFB2
    Novus Biologicals TGFB2 Antibodies
    Abcam antibodies for TGFB2 (P61812, P01137)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TGFB2
    LSBio Antibodies in human, mouse, rat for TGFB2

    TGFB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGFB2
    R&D Systems ELISAs for TGFB2 (TGF-beta 2)         (see all)
    GenScript Custom Assay Services for TGFB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    Selected InterPro protein domains (see all 6):
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR016319 TGF-beta
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P61812

    ProtoNet protein and cluster: P61812

    5 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB003911 Transforming growth factor beta precursor signature
    IPB003940 Transforming growth factor beta 2 precursor signature


    UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
    Similarity: Belongs to the TGF-beta family


    TGFB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFB2_HUMAN, P61812
    Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

         Genatlas biochemistry entry for TGFB2:
    transforming growth factor,beta 2,152.6kDa,homodimerizing,expressed by
    fibroblast,platelet,monocyte,chondrocyte,osteoblasts,including the latency associated peptide (LAP),inhibitor of
    epithelial cell growth and inductor of extracellular matrix formation

         Summary: 
    During embryonic development, TGFB2 as signaling molecule is secreted from the following cells:
          selected tissues (see all 6)      fully expand
    Eye: GABAergic Amacrine Cells (Inner Nuclear Layer), Mature Ganglion Cells (Inner Nuclear Layer)      fully expand to see all 4 cells
    Limb: Prechondrocytic Mesenchymal Cells (Autopod), Prechondrocytic Mesenchymal Cells (Stylopod)      fully expand to see all 3 cells

    It affects the following cells:       fully expand
    Tendon & Ligament: Early Tenocyte Cells (Axial Tendon Primordia), Tenocytes (Limb Tendon Primordia)      fully expand to see all 4 cells
    Eye: Mature Endothelial Cells (Retinal Neuroblastic Layer), Late Retinal Progenitor Cells (Retinal Neuroblastic Layer)      fully expand to see all 3 cells

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IDA16227582
    GO:0004702receptor signaling protein serine/threonine kinase activity IDA12958365
    GO:0005102receptor binding IMP16227582
    GO:0005114type II transforming growth factor beta receptor binding IPI1333888
    GO:0005125cytokine activity TAS9611771
         
    TGFB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TGFB2:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 1 allele(MGI details for Tgfb2) (see all 20):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  muscle  nervous system 

    TGFB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tgfb2tm1Doe for TGFB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGFB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGFB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TGFB2:
    hsa-mir-375 (MIRT019708), hsa-mir-335-5p (MIRT017363), hsa-mir-141-3p (MIRT002285), hsa-mir-21-5p (MIRT030844)

    Block miRNA regulation of human, mouse, rat TGFB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFB2 (see all 105):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-4305 hsa-miR-1245 hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidTGFB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TGFB2
    Predesigned siRNA for gene silencing in human, mouse, rat TGFB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGFB2

    Clone
    Products:
         
    OriGene clones in human, mouse for TGFB2 (see all 11)
    OriGene ORF clones in mouse, rat for TGFB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFB2 (NM_003238)
    Sino Biological Human cDNA Clone for TGFB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGFB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TGFB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGFB2_HUMAN, P61812: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS2119582
    GO:0005615extracellular space IEA--
    GO:0030424axon ISS--
    GO:0031012extracellular matrix IDA18049952
    GO:0031093platelet alpha granule lumen TAS--

    TGFB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TGFB2 About   (see all 64)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TGFB2 (see all 6)
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TGFB2 (see all 68)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for TGFB2
        Angiogenesis
    TGF-beta/Smad Signaling

    2 GeneGo (Thomson Reuters) Pathways for TGFB2
        Cell cycle Regulation of G1/S transition (part 1)
    Cell adhesion Plasmin signaling

    Selected BioSystems Pathways for TGFB2 (see all 7)
        MAPK signaling pathway
    p38 MAPK Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Endochondral Ossification
    Signaling events mediated by the Hedgehog family

    1 Sino Biological Pathway for TGFB2
        TGF-beta Signaling Pathway

    3 Reactome Pathways for TGFB2
        Molecules associated with elastic fibres
    ECM proteoglycans
    Platelet degranulation


    Selected Kegg Pathways  (Kegg details for TGFB2) (see all 27):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    FoxO signaling pathway
    Cell cycle
    Endocytosis


    TGFB2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFB2 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TGFB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGFB2 (P618121, 3 ENSP000003558964) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050671, 3, ENSP000002849814EBI-779581,EBI-77613 I2D: score=3 STRING: ENSP00000284981
    DAXXQ9UER73, ENSP000002660004I2D: score=1 STRING: ENSP00000266000
    ENSG00000206206Q9UER73I2D: score=1 
    ENSG00000206279Q9UER73I2D: score=1 
    ENSG00000227046Q9UER73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 85):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IDA15896309
    GO:0001501skeletal system development ----
    GO:0001502cartilage condensation IEA--
    GO:0001525angiogenesis TAS9611771
    GO:0001568blood vessel development ----

    TGFB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGFB2

    Selected Novoseek inferred chemical compound relationships for TGFB2 gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 81.8 95 15057430 (7), 11453034 (6), 17270215 (6), 11514049 (6) (see all 43)
    vegf 51.6 94 14620032 (6), 19085381 (6), 17331500 (5), 11642726 (4) (see all 38)
    4-hydroxytamoxifen 40.9 3 18043895 (1), 1834933 (1), 8143893 (1)
    ribonucleic acid 40 5 7962292 (1), 8013382 (1), 1280203 (1)
    epsilon-(gamma-glutamyl)lysine 38.4 1 16936095 (1)
    thymidine 37.7 8 16481045 (1), 16402924 (1), 2270434 (1), 8013384 (1) (see all 7)
    retinoic acid 34.6 55 9153223 (5), 15609095 (5), 8603400 (4), 15955085 (4) (see all 15)
    rantes 32.9 7 16249505 (1), 11884483 (1), 12975472 (1), 11342433 (1) (see all 7)
    pge2 27.2 25 10807250 (3), 16400016 (3), 9704780 (3), 14749055 (2) (see all 9)
    indoleamine 25.6 1 17565341 (1)



    TGFB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TGFB2 gene (2 alternative transcripts): 
    NM_001135599.2  NM_003238.3  

    Unigene Cluster for TGFB2:

    Transforming growth factor, beta 2
    Hs.133379  [show with all ESTs]
    Unigene Representative Sequence: NM_001135599
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366930(uc001hlm.3 uc001hlo.3) ENST00000366929(uc001hll.3 uc001hln.3 uc010pue.2)
    ENST00000488793 ENST00000479322
    miRNA
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    Block miRNA regulation of human, mouse, rat TGFB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFB2 (see all 105):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-4305 hsa-miR-1245 hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidTGFB2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TGFB2
    Predesigned siRNA for gene silencing in human, mouse, rat TGFB2
    Clone
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    OriGene clones in human, mouse for TGFB2 (see all 11)
    OriGene ORF clones in mouse, rat for TGFB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFB2 (NM_003238)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB2
    Primer
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    OriGene qPCR primer pairs and template standards for TGFB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TGFB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGFB2
      QuantiTect SYBR Green Assays in human, mouse, rat TGFB2
      QuantiFast Probe-based Assays in human, mouse, rat TGFB2

    Additional mRNA sequence: 

    AK021874.1 AK296504.1 AK313106.1 BC096235.4 BC099635.1 BC099636.1 M19154.1 Y00083.1 

    5 DOTS entries:

    DT.213595  DT.97807399  DT.100745830  DT.86850114  DT.97826963 

    Selected AceView cDNA sequences (see all 126):

    AI276277 BF061658 AI468404 BQ440511 BF445951 BM723925 AI090617 AA233738 
    AA327931 BF732315 CA312162 AL697807 AI074048 BM721214 AI247406 M19154 
    BF109964 BX339694 Y00083 BX370126 AW173038 AW664665 BQ573913 F02865 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TGFB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                          -                                 
    SP2:        -                 -                                 
    SP3:        -                 -           -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for TGFB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TGFB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAAAAAT
    TGFB2 Expression
    About this image


    TGFB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 14 entries
             Hypertrophic Chondrocytes Rib
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Hypertrophic Chondrocytes Rib
     
     Pancreas (Endocrine System)    fully expand to see all 5 entries
             Exocrine Progenitor Cells Dorsal Pancreatic Bud
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Tendon Progenitor Cells Limb Bud
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Endocardial Cells Endocardium
             Cardiomyocyte-like progenitor cells
    TGFB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGFB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133379
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFB2 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TGFB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfb21 , 5 transforming growth factor, beta 21, 5 89.21(n)1
    95.65(a)1
      1 (89.95 cM)5
    218081  NM_009367.31  NP_033393.21 
     1866231865 
    chicken
    (Gallus gallus)
    Aves TGFB21 transforming growth factor, beta 2 85.19(n)
    90.29(a)
      421352  XM_003640970.2  XP_003641018.1 
    lizard
    (Anolis carolinensis)
    Reptilia TGFB26
    transforming growth factor, beta 2
    81(a)
    1 ↔ 1
    1(242486323-242630450)
    African clawed frog
    (Xenopus laevis)
    Amphibia tgfb2-A2 transforming growth factor, beta 2 79.18(n)    X51817.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tgfb22 transforming growth factor, beta 2 75.02(n)   369194  AY338730.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta daw6
    dawdle
    15(a)
    1 → many
    2L(2805518-2812147)


    ENSEMBL Gene Tree for TGFB2 (if available)
    TreeFam Gene Tree for TGFB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TGFB2 gene
    GDF112  MSTN2  INHBE2  INHBB2  TGFB32  INHBC2  INHBA2  TGFB12  
    2 SIMAP similar genes for TGFB2 using alignment to 1 protein entry:     TGFB2_HUMAN:
    TGFB3    TGFB1

    TGFB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGFB2 (see all 2056)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0689324
    Loeys-Dietz syndrome 4 (LDS4)4--see VAR_0689322 R W mis40--------
    VAR_0689344
    Loeys-Dietz syndrome 4 (LDS4)4--see VAR_0689342 P H mis40--------
    VAR_0689334
    Loeys-Dietz syndrome 4 (LDS4)4--see VAR_0689332 R C mis40--------
    rs57810331,2
    C--189255690(+) cacac-/AC/CG 
            
    gcaca
    2 -- int10--------
    rs1449940611,2
    C--189256234(+) AATAC-/ATGCAG
            
    TGATT
    2 -- int10--------
    rs57810351,2
    C--189280565(+) AAAAA-/A/AA/G
            
    GAAAT
    2 -- int11NA 2
    rs106716581,2
    C--218521425(+) agaaa-/GAAA  
            
    aGGGG
    2 -- int1 trp30--------
    rs745860351,2
    C--218541135(+) TTTTT-/TTCTTC 2 -- int10--------
    rs114289251,2
    C--218548780(+) AAAAA-/ACCCAA 2 -- int10--------
    rs113754871,2
    C--218552115(+) TTTTTT/-CTTAT 2 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for TGFB2 (218518676 - 218617961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TGFB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723040CNV Deletion23290073
    nsv832603CNV Gain17160897
    nsv873193CNV Gain21882294
    nsv873192CNV Gain21882294

    Human Gene Mutation Database (HGMD): TGFB2
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing TGFB2:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing TGFB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190220   
    OMIM disorders: 614816  
    UniProtKB/Swiss-Prot: TGFB2_HUMAN, P61812
  • Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation
    t(1;7)(q41;p21) with HDAC9
  • Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]: An aortic aneurysm syndrome with widespread systemic
    involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and
    subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly,
    scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for TGFB2 (see all 168):    
    About MalaCards
    loeys-dietz syndrome, type 4    tgfb2-related loeys-dietz syndrome    macular holes    seborrheic keratosis
    breast cyst    warthin tumor    aortic aneurysm, familial thoracic 4    neovascular glaucoma
    loeys-dietz syndrome type 2a    loeys-dietz syndrome    keratopathy    bullous keratopathy
    keloids    peters plus syndrome    osteochondroma    corneal disease
    autoimmune myocarditis    primary open angle glaucoma    familial thoracic aortic aneurysm and dissection    diabetic foot ulcers

    5 diseases from the University of Copenhagen DISEASES database for TGFB2:
    Macular holes     Glaucoma     Proliferative vitreoretinopathy     Cancer
    Retinal detachment

    TGFB2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TGFB2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitreoretinopathy proliferative 68.1 4 1800167 (1), 15505063 (1), 18253093 (1)
    aqueous humor 67.3 59 17167403 (7), 17278530 (3), 12484701 (2), 19959644 (2) (see all 27)
    macular holes 63.1 41 9544645 (7), 7825689 (4), 8956640 (3), 9098285 (2) (see all 16)
    fuchs heterochromic cyclitis 59.4 1 16249505 (1)
    breast cysts 56.6 4 7852541 (2), 10652596 (1), 18181041 (1)
    glioma 53.8 46 17453002 (5), 19033423 (4), 11331365 (3), 15072445 (3) (see all 19)
    malignant glioma 50.8 9 1874566 (2), 17638524 (2), 9488308 (1), 19465936 (1) (see all 7)
    glioblastoma 50.4 34 12017331 (6), 11776974 (4), 15072445 (3), 1315829 (2) (see all 15)
    conjunctival scarring 48.9 2 15652533 (1), 10476787 (1)
    glaucoma open-angle 47.4 16 17998032 (2), 17251470 (1), 15652533 (1), 11405069 (1) (see all 8)

    Genetic Association Database (GAD): TGFB2
    Human Genome Epidemiology (HuGE) Navigator: TGFB2 (37 documents)

    Export disorders for TGFB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGFB2 gene, integrated from 10 sources (see all 846):
    (articles sorted by number of sources associating them with TGFB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sclera-related gene polymorphisms in high myopia. (PubMed id 19710942)1, 4, 9 Lin H.J....Tsai F.J. (Mol. Vis. 2009)
    2. Transforming growth factor-12 polymorphism and systemic lupus erythematosus. (PubMed id 12064833)1, 4, 9 Alansari A....Ollier W. (J. Rheumatol. 2002)
    3. Transforming growth factor-beta gene polymorphisms in sarcoidosis patients with and without fibrosis. (PubMed id 16778279)1, 4, 9 Kruit A....van den Bosch J.M. (Chest 2006)
    4. A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer. (PubMed id 16885354)1, 4, 9 Beisner J....Knabbe C. (Cancer Res. 2006)
    5. Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. (PubMed id 22772368)1, 2 Lindsay M.E....Loeys B.L. (Nat. Genet. 2012)
    6. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    7. Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. (PubMed id 20585394)1, 4 Sambo M.R....Penha-GonAsalves C. (PLoS ONE 2010)
    8. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    9. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7042 HGNC: 11768 AceView: TGFB2 Ensembl:ENSG00000092969 euGenes: HUgn7042
    ECgene: TGFB2 Kegg: 7042 H-InvDB: TGFB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGFB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgfb2/
    Wikipedia http://en.wikipedia.org/wiki/TGF_beta_2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGFB2 gene:
    Search GeneIP for patents involving TGFB2

    Licensable Technologies for TGFB2 gene:
     Tufts University:  Use of miRNAs to selectively modulate TGF-beta/BMP signaling to treat TGF-beta/BMP mediated disorders
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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