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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGFB1I1 Gene

protein-coding   GIFtS: 62
GCID: GC16P031483

Transforming Growth Factor Beta 1 Induced Transcript 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transforming Growth Factor Beta 1 Induced Transcript 11 2     HIC-52
ARA552 3 5     TSC-52
Androgen Receptor Coactivator 55 KDa Protein2 3     Androgen Receptor Coactivator ARA552
Androgen Receptor-Associated Protein Of 55 KDa2 3     Transforming Growth Factor Beta-1-Induced Transcript 1 Protein2
Hydrogen Peroxide-Inducible Clone 5 Protein2 3     Hic-53
HIC52 5     

External Ids:    HGNC: 117671   Entrez Gene: 70412   Ensembl: ENSG000001406827   OMIM: 6023535   UniProtKB: O432943   

Export aliases for TGFB1I1 gene to outside databases

Previous GC identifers: GC16P030566 GC16P031981 GC16P031480 GC16P031519 GC16P031390 GC16P029043


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGFB1I1 Gene:
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen
and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor
activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for TGFB1I1 Gene: 
TGFB1I1 (transforming growth factor beta 1 induced transcript 1) is a protein-coding gene. Diseases associated with TGFB1I1 include hypertrophic scars, and mesangial proliferative glomerulonephritis, and among its related super-pathways are CCR5 Pathway in Macrophages and Translation Non-genomic (rapid) action of Androgen Receptor. GO annotations related to this gene include I-SMAD binding and transcription coactivator activity. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal
adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors
and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma
membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating
glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role
in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a
zinc-dependent DNA-binding activity

Gene Wiki entry for TGFB1I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGFB1I1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFB1I1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TGFB1I1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFB1I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11

TGFB1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFB1I1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031483:  view genomic region     (about GC identifiers)

Start:
31,482,906 bp from pter      End:
31,489,281 bp from pter
Size:
6,376 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294 (See protein sequence)
Recommended Name: Transforming growth factor beta-1-induced transcript 1 protein  
Size: 461 amino acids; 49814 Da
Subunit: Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3,
TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7 (By similarity). Interacts with AR/androgen receptor in a
ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4,
SMAD3, SRC and talin
Subcellular location: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with
the actin cytoskeleton; colocalizes with stress fibers
Sequence caution: Sequence=AAH32545.1; Type=Erroneous initiation;
Secondary accessions: B2R8D5 Q9BPW3 Q9Y2V5
Alternative splicing: 2 isoforms:  O43294-1   O43294-2   

Explore the universe of human proteins at neXtProt for TGFB1I1: NX_O43294

Explore proteomics data for TGFB1I1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by gonadotropin-releasing hormone-activated SRC
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43294

  • TGFB1I1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TGFB1I1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035919.1  NP_001158191.1  NP_057011.2  

    ENSEMBL proteins: 
     ENSP00000456783   ENSP00000456341   ENSP00000378332   ENSP00000459283   ENSP00000455709  
     ENSP00000456482   ENSP00000378327   ENSP00000457586   ENSP00000454688   ENSP00000355117  

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    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10075738
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IEA--
    GO:0016363nuclear matrix IEA--

    TGFB1I1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017305 Leupaxin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O43294

    ProtoNet protein and cluster: O43294

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
    Domain: The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2,
    ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains
    mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4
    domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1,
    homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with
    PTPN12
    Domain: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear
    export signal
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    TGFB1I1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFI1_HUMAN, O43294
    Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal
    adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors
    and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma
    membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating
    glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role
    in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a
    zinc-dependent DNA-binding activity
    Induction: Up-regulated by TNF and hydrogen peroxide

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI10604475
    GO:0008270zinc ion binding IEA--
    GO:0048495Roundabout binding IPI19855388
    GO:0050681androgen receptor binding NAS15572661
         
    TGFB1I1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TGFB1I1:
     Decreased focal adhesion (FA)  

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TGFB1I1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Androgen Signaling
    Androgen Signaling0.52
    2Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49
    3Rho Family GTPases
    ILK Signaling0.49
    4Monoamine Transport
    Monoamine Transport
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TGFB1I1
        Transcription Androgen Receptor nuclear signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TGFB1I1
        ILK Signaling
    Androgen Signaling

    1 Cell Signaling Technology (CST) Pathway for TGFB1I1
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for TGFB1I1
        Transcription Androgen Receptor nuclear signaling

    3 BioSystems Pathways for TGFB1I1
        Androgen receptor signaling pathway
    Monoamine Transport
    Coregulation of Androgen receptor activity



    TGFB1I1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGFB1I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for TGFB1I1 (O432941, 2, 3 ENSP000003783324) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3MINT-61742 I2D: score=3 
    PTK2Q053972, 3, ENSP000003411894MINT-8267630 I2D: score=5 STRING: ENSP00000341189
    ITGA4P136121, 3, ENSP000003802274EBI-1051449,EBI-703044 I2D: score=2 STRING: ENSP00000380227
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863575 I2D: score=3 STRING: ENSP00000357292
    PTK2BQ142893, ENSP000003328164I2D: score=4 STRING: ENSP00000332816
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS10075738
    GO:0007155cell adhesion TAS9422762
    GO:0008285negative regulation of cell proliferation TAS7929412
    GO:0009408response to heat IEA--
    GO:0010718positive regulation of epithelial to mesenchymal transition IDA18762808

    TGFB1I1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TGFB1I1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TGFB1I1 (TGFI1)

    9 Novoseek inferred chemical compound relationships for TGFB1I1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyflutamide 73.2 4 10405524 (1), 11501969 (1), 10075738 (1)
    testosterone 56.9 27 17202804 (4), 11856738 (2), 16624805 (2), 15879885 (2) (see all 11)
    roxithromycin 51.4 4 11532379 (2), 15519139 (1)
    tyrosine 33.4 20 11311131 (5), 9756887 (3), 17233630 (3), 16183059 (2) (see all 7)
    hydrogen 13.7 5 9756887 (1), 7929412 (1), 20448481 (1), 9422762 (1) (see all 5)
    steroid 12.1 1 17202804 (1)
    zinc 8.1 2 16624805 (1), 7929412 (1)
    oxygen 3.25 5 11532379 (2), 15706082 (1)
    h2o2 0 1 12400158 (1)

    Search CenterWatch for drugs/clinical trials and news about TGFB1I1 / TGFI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TGFB1I1 gene (3 alternative transcripts): 
    NM_001042454.2  NM_001164719.1  NM_015927.4  

    Unigene Cluster for TGFB1I1:

    Transforming growth factor beta 1 induced transcript 1
    Hs.513530  [show with all ESTs]
    Unigene Representative Sequence: AK122975
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565454 ENST00000567066 ENST00000394863(uc002ecd.2) ENST00000567524
    ENST00000563712 ENST00000561785 ENST00000569254 ENST00000565360 ENST00000562165
    ENST00000564176 ENST00000569703 ENST00000562566 ENST00000394858(uc002ece.2)
    ENST00000567607 ENST00000568142 ENST00000564804 ENST00000361773(uc021tgx.1)


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    Additional mRNA sequence: 

    AB007836.1 AF116343.1 AK122975.1 AK313327.1 BC001507.3 BC001830.2 BC017288.2 BC032545.1 

    12 DOTS entries:

    DT.100687614  DT.120684137  DT.214523  DT.101977346  DT.120684154  DT.120684146  DT.40122548  DT.100793991 
    DT.120684140  DT.120684144  DT.95320882  DT.100653567 

    24/249 AceView cDNA sequences (see all 249):

    AW613033 BU521445 AI288944 CR618728 CR608741 CR624726 BM546073 NM_015927 
    BP373936 BU726504 CR604915 AI081940 AA369195 BI824603 BP375195 AA448871 
    BF724260 CB124835 AI086867 BC017288 CR604999 AW305044 CB129823 CR608842 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                        -                             -     -                       -               
    SP2:                          -                             -                             -     -                                       
    SP3:        -     -     -     -                             -                                                                           
    SP4:                          -                             -                                                                           
    SP5:                          -                 -           -                                                                           


    ECgene alternative splicing isoforms for TGFB1I1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TGFB1I1 expression in normal human tissues (normalized intensities)      TGFB1I1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTTCTGC
    TGFB1I1 Expression
    About this image


    TGFB1I1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/bladder   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros

    See TGFB1I1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TGFB1I1

    SOURCE GeneReport for Unigene cluster: Hs.513530

    UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
    Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including TGFB1I1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Cellular Senescence in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TGFB1I1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfb1i11 , 5 transforming growth factor beta 1 induced transcript more1, 5 87.16(n)1
    90.99(a)1
      7 (70.07 cM)5
    218041  NM_009365.21  NP_033391.11 
     1282468125 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pax3 cytoskeletal anchoring cytoskeletal
    anchor protein
    57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.63 LIM domains 51(a)   III(5962097-5964317)   --


    ENSEMBL Gene Tree for TGFB1I1 (if available)
    TreeFam Gene Tree for TGFB1I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TGFB1I1 gene
    ABLIM32  LIMS12  LIMS3L2  DMTN2  LDB32  FHL52  LPXN2  PDLIM52  
    ENSG000002572072  ABLIM22  LIMS22  FHL22  ABLIM12  PDLIM72  FHL32  FHL12  
    LIMS32  PXN2  
    8 SIMAP similar genes for TGFB1I1 using alignment to 7 protein entries:     TGFI1_HUMAN (see all proteins):
    LPXN    PXN    DKFZp686P2249    CRIP2    LHx4    FHL3
    LMO1    LMO3

    TGFB1I1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 SNPs in TGFB1I1 are shown (see all 173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434121221,2
    --31481542(+) CAGGTG/TCCTGC 2 -- us2k10--------
    rs1830802501,2
    --31481737(+) TCGCTC/GTGTTG 2 -- us2k10--------
    rs1482936821,2
    C--31481815(+) CTTCCA/GCCTCA 2 -- us2k10--------
    rs1877501741,2
    --31482137(+) TATATA/TACTTC 2 -- us2k10--------
    rs1162499971,2
    F--31482149(+) TTGAAC/TTGTCT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1414266101,2
    --31482270(+) CCTCCA/GGGTTT 2 -- us2k10--------
    rs3681570821,2
    C--31482322(+) ACAGGC/GTCCCA 2 -- us2k10--------
    rs1463223621,2
    --31482423(+) CTGCCC/TGCCTT 2 -- us2k10--------
    rs1178004431,2
    C,F--31482455(+) TATAGG/ATGTGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs575107231,2
    C,F--31482528(+) TGATAC/ATCACA 3 -- us2k12Minor allele frequency- A:0.08WA 120

    HapMap Linkage Disequilibrium report for TGFB1I1 (31482906 - 31489281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TGFB1I1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602353    OMIM disorders: --

    13 diseases for TGFB1I1:    About MalaCards
    hypertrophic scars    mesangial proliferative glomerulonephritis    acne    proliferative glomerulonephritis
    prostate cancer    keloids    wiskott-aldrich syndrome    azoospermia
    prostatitis    endometriosis    glomerulonephritis    endotheliitis
    alzheimer's disease


    TGFB1I1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for TGFB1I1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 48 24 12858356 (9), 11501969 (2), 12700349 (2), 10075738 (2) (see all 7)
    necrosis 0 2 11489729 (2)
    tumors 0 7 11489729 (2), 10075738 (1), 7929412 (1), 17364555 (1) (see all 5)
    cancer 0 2 17364555 (1), 11489729 (1)


    Export disorders for TGFB1I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TGFB1I1 gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with TGFB1I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PubMed id 9422762)1, 2, 3, 9 Matsuya M.... Sasaki T. (1998)
    2. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PubMed id 10075738)1, 2, 3, 9 Fujimoto N....Chang C. (1999)
    3. Transcriptional activation of the c-fos gene by a LIM protein, Hic- 5. (PubMed id 12445807)1, 2, 9 Kim-Kaneyama J.-R.... Nose K. (2002)
    4. Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. (PubMed id 15561701)1, 2, 9 Wang H.... Danielpour D. (2005)
    5. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. (PubMed id 11856738)1, 2, 9 Wang X.... Chang C. (2002)
    6. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PubMed id 16624805)1, 2, 9 Saelzler M.P....Abe M.K. (2006)
    7. Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. (PubMed id 9756887)1, 2, 9 Fujita H....Tachibana K. (1998)
    8. Induction of senescence-like phenotypes by forced expression of hic- 5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. (PubMed id 9032249)1, 2, 9 Shibanuma M.... Nose K. (1997)
    9. Hic-5 regulates an epithelial program mediated by PPARgamma. (PubMed id 15687259)1, 2, 9 Drori S.... Spiegelman B.M. (2005)
    10. Hic-5/ARA55 a prostate stroma-specific AR coactivator. (PubMed id 17166536)1, 2 Heitzer M.D. and DeFranco D.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7041 HGNC: 11767 AceView: TGFB1I1 Ensembl:ENSG00000140682 euGenes: HUgn7041
    ECgene: TGFB1I1 H-InvDB: TGFB1I1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TGFB1I1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFB1I1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgfb1i1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TGFB1I1 gene:
    Search GeneIP for patents involving TGFB1I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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