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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TGFB1I1 Gene

protein-coding GIFtS: 60
GCID: GC16P031483

transforming growth factor beta 1 induced transcript 1

Explore 9 diseases affiliated with
TGFB1I1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transforming Growth Factor Beta 1 Induced Transcript 1¹ ²		Androgen Receptor-Associated Protein Of 55 KDa² ³
ARA55¹ ² ³ ⁵		Hydrogen Peroxide-Inducible Clone 5 Protein² ³
HIC-5¹ ²		HIC5² ⁵
TSC-5¹ ²		Androgen Receptor Coactivator ARA55²
Hic-5¹ ³		Transforming Growth Factor Beta-1-Induced Transcript 1 Protein²
Androgen Receptor Coactivator 55 KDa Protein² ³

External Ids:	HGNC: 11767¹	Entrez Gene: 7041²	Ensembl: ENSG00000140682⁷	OMIM: 602353⁵	UniProtKB: O43294³

Export aliases for TGFB1I1 gene to outside databases

Previous GC identifers: GC16P030566 GC16P031981 GC16P031480 GC16P031519 GC16P031390 GC16P029043

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGFB1I1:

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has

a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and

may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294

Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion

complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates

the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence

regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid,

androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of

cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity

Gene Wiki entry for TGFB1I1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TGFB1I1 gene promoter:
COUP-TF1 COUP-TF COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TGFB1I1 promoter sequence

Search SABiosciences Chromatin IP Primers for TGFB1I1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFB1I1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11

TGFB1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFB1I1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P031483: view genomic region (about GC identifiers)

Start:	31,482,906 bp from pter	End:	31,489,281 bp from pter
Size:	6,376 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294 (See protein sequence)

Recommended Name: Transforming growth factor beta-1-induced transcript 1 protein

Size: 461 amino acids; 49814 Da

Subunit: Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2

and VCL. Forms a complex with GIT1 and ARHGEF7 (By similarity). Interacts with AR/androgen receptor in a

ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3,

SRC and talin

Subcellular location: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the

actin cytoskeleton; colocalizes with stress fibers

Sequence caution: Sequence=AAH32545.1; Type=Erroneous initiation;

Secondary accessions: B2R8D5 Q9BPW3 Q9Y2V5

Alternative splicing: 2 isoforms: O43294-1 O43294-2

Explore the universe of human proteins at neXtProt for TGFB1I1: NX_O43294

Post-translational modifications:

Phosphorylated by gonadotropin-releasing hormone-activated SRC¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43294

TGFB1I1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035919.1 NP_001158191.1 NP_057011.2

ENSEMBL proteins:

ENSP00000456783 ENSP00000456341 ENSP00000378332 ENSP00000459283 ENSP00000455709

ENSP00000456482 ENSP00000378327 ENSP00000457586 ENSP00000454688 ENSP00000355117

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	10075738
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005925	focal adhesion	IEA	--
GO:0016363	nuclear matrix	IEA	--

TGFB1I1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TGFB1I1 for domains About GeneDecksing

2 InterPro domains/families:

IPR017305 Leupaxin

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry O43294

ProtoNet protein and cluster: O43294

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294

Domain: The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK,

LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate

targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate

interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization

and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12

Domain: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export

signal

Similarity: Belongs to the paxillin family

Similarity: Contains 4 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294

Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion

complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates

the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence

regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid,

androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of

cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity

Induction: Up-regulated by TNF and hydrogen peroxide

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In Situ Assay
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Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	NAS	15572661
GO:0005515	protein binding	IPI	10604475
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	--	--
GO:0048495	Roundabout binding	IPI	19855388

TGFB1I1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TGFB1I1:

Decreased focal adhesion (FA)

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Adhesion

Adhesion

1.00

Androgen Signaling

Androgen Signaling

1.00

Monoamine Transport

Monoamine Transport

1.00

Androgen receptor signaling pathway

Androgen receptor signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TGFB1I1

Transcription Androgen Receptor nuclear signaling

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TGFB1I1

	ILK Signaling
	Androgen Signaling

1 Cell Signaling Technology (CST) Pathway for TGFB1I1

Adhesion

1 GeneGo (Thomson Reuters) Pathway for TGFB1I1

Transcription Androgen Receptor nuclear signaling

3 BioSystems Pathways for TGFB1I1

	Androgen receptor signaling pathway
	Monoamine Transport
	Coregulation of Androgen receptor activity

TGFB1I1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TGFB1I1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for TGFB1I1 (O43294^{1, 2, 3} ENSP00000378332⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIPK3	Q9H422²^,³	MINT-61742 I2D: score=3
PTK2	Q05397²^,³, ENSP00000341189⁴	MINT-8267630 I2D: score=5 STRING: ENSP00000341189
ITGA4	P13612¹^,³, ENSP00000380227⁴	EBI-1051449,EBI-703044 I2D: score=2 STRING: ENSP00000380227
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2863575 I2D: score=3 STRING: ENSP00000357292
PTK2B	Q14289³, ENSP00000332816⁴	I2D: score=4 STRING: ENSP00000332816

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	TAS	10075738
GO:0007155	cell adhesion	TAS	9422762
GO:0008285	negative regulation of cell proliferation	TAS	7929412
GO:0009408	response to heat	IEA	--
GO:0010718	positive regulation of epithelial to mesenchymal transition	IDA	18762808

TGFB1I1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TGFB1I1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TGFB1I1
9 Novoseek chemical compound relationships for TGFB1I1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyflutamide	73.2	4	10405524 (1), 11501969 (1), 10075738 (1)
testosterone	56.9	27	17202804 (4), 11856738 (2), 16624805 (2), 15879885 (2) (see all 11)
roxithromycin	51.4	4	11532379 (2), 15519139 (1)
tyrosine	33.4	20	11311131 (5), 9756887 (3), 17233630 (3), 16183059 (2) (see all 7)
hydrogen	13.7	5	9756887 (1), 7929412 (1), 20448481 (1), 9422762 (1) (see all 5)
steroid	12.1	1	17202804 (1)
zinc	8.1	2	16624805 (1), 7929412 (1)
oxygen	3.25	5	11532379 (2), 15706082 (1)
h2o2	0	1	12400158 (1)

Search CenterWatch for drugs/clinical trials and news about TGFB1I1 / TGFI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TGFB1I1 gene (3 alternative transcripts):

NM_001042454.2 NM_001164719.1 NM_015927.4

Unigene Cluster for TGFB1I1:

Transforming growth factor beta 1 induced transcript 1

Hs.513530 [show with all ESTs]

Unigene Representative Sequence: AK122975

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565454 ENST00000567066 ENST00000394863(uc002ecd.2) ENST00000567524

ENST00000563712 ENST00000561785 ENST00000569254 ENST00000565360 ENST00000562165

ENST00000564176 ENST00000569703 ENST00000562566 ENST00000394858(uc002ece.2)

ENST00000567607 ENST00000568142 ENST00000564804 ENST00000361773(uc021tgx.1)

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Additional cDNA sequence:

AB007836.1 AF116343.1 AK122975.1 AK313327.1 BC001507.3 BC001830.2 BC017288.2 BC032545.1

12 DOTS entries:

DT.100687614 DT.120684137 DT.214523 DT.101977346 DT.120684154 DT.120684146 DT.40122548 DT.100793991

DT.120684140 DT.120684144 DT.95320882 DT.100653567

24/249 AceView cDNA sequences (see all 249):

BP373936 AI436309 AI290304 AW613033 AI288944 AA629077 BC032545 CR608741

CR602627 CR617942 BQ183340 CR603592 BI825662 BP341881 CB149477 BU521445

CR618728 BU501301 CR604915 BX425042 CR618748 BU527723 BP375195 BU726504

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13
SP1:																			-										-		-								-
SP2:									-										-										-		-
SP3:			-		-		-		-										-
SP4:									-										-
SP5:									-						-				-

ECgene alternative splicing isoforms for TGFB1I1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TGFB1I1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCTTCTGC

About this image

TGFB1I1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TGFB1I1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGFB1I1

SOURCE GeneReport for Unigene cluster: Hs.513530

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294

Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including TGFB1I1:

TGFB/BMP Signaling Pathway in human mouse rat

Neurotrophins & Receptors in human mouse rat

Cellular Senescence in human mouse rat

Prostate Cancer in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TGFB1I1 gene from 3/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TGFB1I1⁶	--	45(a)	1 ↔ 1	GL343220.1(2476202-2494507)
fruit fly (Drosophila melanogaster)	Insecta	Pax³	cytoskeletal anchoring cytoskeletal anchor protein	57(a)		--
worm (Caenorhabditis elegans)	Secernentea	C28H8.6³	LIM domains	51(a)		III(5962097-5964317) --

ENSEMBL Gene Tree for TGFB1I1 (if available)
TreeFam Gene Tree for TGFB1I1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TGFB1I1 gene

ABLIM3² LIMS1² LIMS3L² FHL5² LDB3² LPXN² ABLIM2² PDLIM5²

ENSG00000257207² LIMS2² FHL2² ABLIM1² PDLIM7² EPB49² FHL3² FHL1²

LIMS3² PXN²

11 SIMAP similar genes for TGFB1I1 using alignment to 7 protein entries: TGFI1_HUMAN (see all proteins):

LPXN PXN DKFZp686P2249 CRIP2 LHx4 FHL3

LMO1 LMO3 CRIP1 LIMS1 LIMS2

TGFB1I1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143412122^1,2		--	31481542(+)	`CAGGTG/TCCTGC`	2	--	us2k¹		0	--	--	--	--
rs183080250^1,2		--	31481737(+)	`TCGCTC/GTGTTG`	2	--	us2k¹		0	--	--	--	--
rs148293682^1,2	C,	--	31481815(+)	`CTTCCA/GCCTCA`	2	--	us2k¹		0	--	--	--	--
rs187750174^1,2		--	31482137(+)	`TATATA/TACTTC`	2	--	us2k¹		0	--	--	--	--
rs116249997^1,2	F,	--	31482149(+)	`TTGAAC/TTGTCT`	2	--	us2k¹		1		WA	118
rs141426610^1,2		--	31482270(+)	`CCTCCA/GGGTTT`	2	--	us2k¹		0	--	--	--	--
rs146322362^1,2		--	31482423(+)	`CTGCCC/TGCCTT`	2	--	us2k¹		0	--	--	--	--
rs117800443^1,2	F,	--	31482455(+)	`TATAGG/ATGTGA`	2	--	us2k¹		1		NA	120
rs114947571^1,2	C,	--	31482478(+)	`GTCTCC/GCATTT`	2	--	us2k¹		0	--	--	--	--
rs57510723^1,2	C,	--	31482528(+)	`TGATAC/ATCACA`	3	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for TGFB1I1 (31482906 - 31489281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TGFB1I1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TGFB1I1 for disorders           About GeneDecksing

OMIM gene information: 602353    OMIM disorders: --

9 diseases for TGFB1I1:    About MalaCards

prostate cancer wiskott-aldrich syndrome prostatitis acne

keloids azoospermia alzheimer's disease endometriosis

ataxia

4 Novoseek disease relationships for TGFB1I1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	48	24	12858356 (9), 11501969 (2), 12700349 (2), 10075738 (2) (see all 7)
necrosis	0	2	11489729 (2)
tumors	0	7	11489729 (2), 10075738 (1), 7929412 (1), 17364555 (1) (see all 5)
cancer	0	2	17364555 (1), 11489729 (1)

Export disorders for TGFB1I1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TGFB1I1 gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with TGFB1I1)

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Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PubMed id 9422762)^{1, 2, 3, 9} Matsuya M.... Sasaki T. (1998)
Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PubMed id 10075738)^{1, 2, 3, 9} Fujimoto N....Chang C. (1999)
Transcriptional activation of the c-fos gene by a LIM protein, Hic- 5. (PubMed id 12445807)^{1, 2, 9} Kim-Kaneyama J.-R.... Nose K. (2002)
Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. (PubMed id 15561701)^{1, 2, 9} Wang H.... Danielpour D. (2005)
Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. (PubMed id 11856738)^{1, 2, 9} Wang X.... Chang C. (2002)
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PubMed id 16624805)^{1, 2, 9} Saelzler M.P....Abe M.K. (2006)
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. (PubMed id 9756887)^{1, 2, 9} Fujita H....Tachibana K. (1998)
Induction of senescence-like phenotypes by forced expression of hic- 5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. (PubMed id 9032249)^{1, 2, 9} Shibanuma M.... Nose K. (1997)
Hic-5/ARA55 a prostate stroma-specific AR coactivator. (PubMed id 17166536)^{1, 2} Heitzer M.D. and DeFranco D.B. (2007)
Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells. (PubMed id 16849583)^{1, 2} Heitzer M.D. and DeFranco D.B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7041	HGNC: 11767	AceView: TGFB1I1	Ensembl:ENSG00000140682	euGenes: HUgn7041
ECgene: TGFB1I1	H-InvDB: TGFB1I1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TGFB1I1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TGFB1I1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tgfb1i1/

Intellectual Property for TGFB1I1 gene
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Patent Information for TGFB1I1 gene:
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TGFB1I1 Gene

transforming growth factor beta 1 induced transcript 1

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TGFB1I1 Gene

transforming growth factor beta 1 induced transcript 1

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