Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TGFB1I1 Gene

protein-coding   GIFtS: 63
GCID: GC16P031483

Transforming Growth Factor Beta 1 Induced Transcript 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transforming Growth Factor Beta 1 Induced Transcript 11 2     HIC-52
ARA552 3 5     TSC-52
Androgen Receptor Coactivator 55 KDa Protein2 3     Androgen Receptor Coactivator ARA552
Androgen Receptor-Associated Protein Of 55 KDa2 3     Transforming Growth Factor Beta-1-Induced Transcript 1 Protein2
Hydrogen Peroxide-Inducible Clone 5 Protein2 3     Hic-53
HIC52 5     

External Ids:    HGNC: 117671   Entrez Gene: 70412   Ensembl: ENSG000001406827   OMIM: 6023535   UniProtKB: O432943   
ORGUL members:         

Export aliases for TGFB1I1 gene to outside databases

Previous GC identifers: GC16P030566 GC16P031981 GC16P031480 GC16P031519 GC16P031390 GC16P029043


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TGFB1I1 Gene:
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen
and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor
activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for TGFB1I1 Gene:
TGFB1I1 (transforming growth factor beta 1 induced transcript 1) is a protein-coding gene. Diseases associated with TGFB1I1 include hypertrophic scars, and mesangial proliferative glomerulonephritis. GO annotations related to this gene include I-SMAD binding and transcription coactivator activity. An important paralog of this gene is LIMS1.

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal
adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors
and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma
membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating
glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role
in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a
zinc-dependent DNA-binding activity

Gene Wiki entry for TGFB1I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGFB1I1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFB1I1 promoter sequence
   Search Chromatin IP Primers for TGFB1I1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFB1I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11

TGFB1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFB1I1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031483:  view genomic region     (about GC identifiers)

Start:
31,482,906 bp from pter      End:
31,489,281 bp from pter
Size:
6,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294 (See protein sequence)
Recommended Name: Transforming growth factor beta-1-induced transcript 1 protein  
Size: 461 amino acids; 49814 Da
Subunit: Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3,
TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent
manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and
talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct
and enhances CBLC E3 ubiquitin-protein ligase activity
Sequence caution: Sequence=AAH32545.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R8D5 Q9BPW3 Q9Y2V5
Alternative splicing: 2 isoforms:  O43294-1   O43294-2   

Explore the universe of human proteins at neXtProt for TGFB1I1: NX_O43294

Explore proteomics data for TGFB1I1 at MOPED

Post-translational modifications: 

  • Phosphorylated by gonadotropin-releasing hormone-activated SRC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TGFB1I1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035919.1  NP_001158191.1  NP_057011.2  

    ENSEMBL proteins: 
     ENSP00000456783   ENSP00000456341   ENSP00000378332   ENSP00000459283   ENSP00000455709  
     ENSP00000456482   ENSP00000378327   ENSP00000457586   ENSP00000454688   ENSP00000355117  

    TGFB1I1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TGFB1I1
    OriGene Protein Over-expression Lysate for TGFB1I1
    OriGene MassSpec for TGFB1I1
    OriGene Custom Protein Services for TGFB1I1
    GenScript Custom Purified and Recombinant Proteins Services for TGFB1I1
    Novus Biologicals TGFB1I1 Protein
    Novus Biologicals TGFB1I1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TGFB1I1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TGFB1I1 (HIC5/TGFB1I1)
    Cell Signaling Technology (CST) Antibodies for TGFB1I1  (Hic-5)
    OriGene Antibodies for TGFB1I1
    OriGene Custom Antibody Services for TGFB1I1
    Novus Biologicals TGFB1I1 Antibodies
    Abcam antibodies for TGFB1I1 (Q9BPW3, O43294)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TGFB1I1
    LSBio Antibodies in human, mouse, rat for TGFB1I1

    TGFB1I1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGFB1I1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TGFB1I1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR017305 Tgfb1i1/Leupaxin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O43294

    ProtoNet protein and cluster: O43294

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
    Domain: The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2,
    ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains
    mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4
    domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1,
    homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with
    PTPN12
    Domain: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear
    export signal
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    TGFB1I1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFI1_HUMAN, O43294
    Function: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal
    adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors
    and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma
    membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating
    glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role
    in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a
    zinc-dependent DNA-binding activity
    Induction: Up-regulated by TNF and hydrogen peroxide

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI10604475
    GO:0008270zinc ion binding IEA--
    GO:0048495Roundabout binding IPI19855388
    GO:0050681androgen receptor binding NAS15572661
         
    TGFB1I1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TGFB1I1:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFB1I1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFB1I1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGFB1I1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGFB1I1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TGFB1I1:
    hsa-mir-124-3p (MIRT022662), hsa-mir-26b-5p (MIRT029598)

    Block miRNA regulation of human, mouse, rat TGFB1I1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFB1I1 (see all 14):
    hsa-miR-3673 hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTGFB1I1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TGFB1I1
    Predesigned siRNA for gene silencing in human, mouse, rat TGFB1I1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGFB1I1

    Clone
    Products:
         
    OriGene clones in human, mouse for TGFB1I1 (see all 19)
    OriGene ORF clones in mouse, rat for TGFB1I1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TGFB1I1 (NM_015927)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB1I1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB1I1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGFB1I1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TGFB1I1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB1I1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TGFI1_HUMAN, O43294: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with
    the actin cytoskeleton; colocalizes with stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10075738
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IEA--
    GO:0016363nuclear matrix IEA--

    TGFB1I1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TGFB1I1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Monoamine Transport
    Monoamine Transport
    Serotonin Transporter Activity0.00
    2Androgen Signaling
    Androgen Signaling0.52
    3Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49
    4ERK Signaling
    ILK Signaling0.49
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TGFB1I1
        ILK Signaling
    Androgen Signaling

    1 Cell Signaling Technology (CST) Pathway for TGFB1I1
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for TGFB1I1
        Transcription Androgen Receptor nuclear signaling

    4 BioSystems Pathways for TGFB1I1
        Androgen receptor signaling pathway
    Monoamine Transport
    Serotonin Transporter Activity
    Coregulation of Androgen receptor activity



    TGFB1I1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFB1I1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Cellular Senescence in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TGFB1I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGFB1I1 (O432941, 2, 3 ENSP000003783324) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3MINT-61742 I2D: score=3 
    PTK2Q053971, 2, 3, ENSP000003411894EBI-1051449,EBI-702142 MINT-8267630 I2D: score=5 STRING: ENSP00000341189
    ITGA4P136121, 3, ENSP000003802274EBI-1051449,EBI-703044 I2D: score=2 STRING: ENSP00000380227
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863575 I2D: score=3 STRING: ENSP00000357292
    PTK2BQ142893, ENSP000003328164I2D: score=4 STRING: ENSP00000332816
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS10075738
    GO:0007155cell adhesion TAS9422762
    GO:0008285negative regulation of cell proliferation TAS7929412
    GO:0009408response to heat IEA--
    GO:0010718positive regulation of epithelial to mesenchymal transition IDA18762808

    TGFB1I1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGFB1I1 (TGFI1)

    9 Novoseek inferred chemical compound relationships for TGFB1I1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyflutamide 73.2 4 10405524 (1), 11501969 (1), 10075738 (1)
    testosterone 56.9 27 17202804 (4), 11856738 (2), 16624805 (2), 15879885 (2) (see all 11)
    roxithromycin 51.4 4 11532379 (2), 15519139 (1)
    tyrosine 33.4 20 11311131 (5), 9756887 (3), 17233630 (3), 16183059 (2) (see all 7)
    hydrogen 13.7 5 9756887 (1), 7929412 (1), 20448481 (1), 9422762 (1) (see all 5)
    steroid 12.1 1 17202804 (1)
    zinc 8.1 2 16624805 (1), 7929412 (1)
    oxygen 3.25 5 11532379 (2), 15706082 (1)
    h2o2 0 1 12400158 (1)



    TGFB1I1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TGFB1I1 gene (3 alternative transcripts): 
    NM_001042454.2  NM_001164719.1  NM_015927.4  

    Unigene Cluster for TGFB1I1:

    Transforming growth factor beta 1 induced transcript 1
    Hs.513530  [show with all ESTs]
    Unigene Representative Sequence: AK122975
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565454 ENST00000567066 ENST00000394863(uc002ecd.2) ENST00000567524
    ENST00000563712 ENST00000561785 ENST00000569254 ENST00000565360 ENST00000562165
    ENST00000564176 ENST00000569703 ENST00000562566 ENST00000394858(uc002ece.2)
    ENST00000567607 ENST00000568142 ENST00000564804 ENST00000361773(uc021tgx.1)


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TGFB1I1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFB1I1 (see all 14):
    hsa-miR-3673 hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTGFB1I1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TGFB1I1
    Predesigned siRNA for gene silencing in human, mouse, rat TGFB1I1
    Clone
    Products:
         
    OriGene clones in human, mouse for TGFB1I1 (see all 19)
    OriGene ORF clones in mouse, rat for TGFB1I1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TGFB1I1 (NM_015927)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFB1I1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB1I1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TGFB1I1
    OriGene qSTAR qPCR primer pairs in human, mouse for TGFB1I1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGFB1I1
      QuantiTect SYBR Green Assays in human, mouse, rat TGFB1I1
      QuantiFast Probe-based Assays in human, mouse, rat TGFB1I1

    Additional mRNA sequence: 

    AB007836.1 AF116343.1 AK122975.1 AK313327.1 BC001507.3 BC001830.2 BC017288.2 BC032545.1 

    12 DOTS entries:

    DT.100687614  DT.120684137  DT.214523  DT.101977346  DT.120684154  DT.120684146  DT.40122548  DT.100793991 
    DT.120684140  DT.120684144  DT.95320882  DT.100653567 

    Selected AceView cDNA sequences (see all 249):

    AL551935 CR616164 CR621063 CR624726 BI824603 BP373936 BP340861 BI825662 
    CR617942 AI424379 BQ183340 BC001830 BP375195 AA369195 BU726504 CR604915 
    BM468588 AA448871 CB124835 BF724260 BU527723 AI086867 CR618748 CR604999 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                        -                             -     -                       -               
    SP2:                          -                             -                             -     -                                       
    SP3:        -     -     -     -                             -                                                                           
    SP4:                          -                             -                                                                           
    SP5:                          -                 -           -                                                                           


    ECgene alternative splicing isoforms for TGFB1I1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TGFB1I1 expression in normal human tissues (normalized intensities)      TGFB1I1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTTCTGC
    TGFB1I1 Expression
    About this image


    TGFB1I1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Esophagus (Gastrointestinal Tract)
    TGFB1I1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TGFB1I1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513530

    UniProtKB/Swiss-Prot: TGFI1_HUMAN, O43294
    Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFB1I1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Cellular Senescence in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TGFB1I1
    OriGene qSTAR qPCR primer pairs in human, mouse for TGFB1I1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGFB1I1
    QuantiTect SYBR Green Assays in human, mouse, rat TGFB1I1
    QuantiFast Probe-based Assays in human, mouse, rat TGFB1I1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB1I1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TGFB1I1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfb1i11 , 5 transforming growth factor beta 1 induced transcript more1, 5 87.16(n)1
    90.99(a)1
      7 (70.07 cM)5
    218041  NM_009365.21  NP_033391.11 
     1282468125 
    lizard
    (Anolis carolinensis)
    Reptilia TGFB1I16
    transforming growth factor beta 1 induced transcri...
    58(a)
    1 ↔ 1
    GL343220.1(2473946-2508040)
    zebrafish
    (Danio rerio)
    Actinopterygii ldb3a6
    LIM-domain binding factor 3a
    17(a)
    many ↔ many
    13(22616977-22690023) ENSDARG00000056322
    fruit fly
    (Drosophila melanogaster)
    Insecta Pax3 cytoskeletal anchoring cytoskeletal
    anchor protein
    57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.63 LIM domains 51(a)   III(5962097-5964317)   --


    ENSEMBL Gene Tree for TGFB1I1 (if available)
    TreeFam Gene Tree for TGFB1I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TGFB1I1 gene
    LIMS12  PDLIM72  LIMS3L2  FHL32  FHL52  LDB32  LPXN2  FHL12  
    ENSG000002572072  LIMS32  PDLIM52  PXN2  LIMS22  FHL22  
    8 SIMAP similar genes for TGFB1I1 using alignment to 7 protein entries:     TGFI1_HUMAN (see all proteins):
    LPXN    PXN    DKFZp686P2249    CRIP2    LHx4    FHL3
    LMO1    LMO3

    TGFB1I1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TGFB1I1 (see all 173)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434121221,2
    --31481542(+) CAGGTG/TCCTGC 2 -- us2k10--------
    rs1830802501,2
    --31481737(+) TCGCTC/GTGTTG 2 -- us2k10--------
    rs1482936821,2
    C--31481815(+) CTTCCA/GCCTCA 2 -- us2k10--------
    rs1877501741,2
    --31482137(+) TATATA/TACTTC 2 -- us2k10--------
    rs1162499971,2
    F--31482149(+) TTGAAC/TTGTCT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1414266101,2
    --31482270(+) CCTCCA/GGGTTT 2 -- us2k10--------
    rs3681570821,2
    C--31482322(+) ACAGGC/GTCCCA 2 -- us2k10--------
    rs1463223621,2
    --31482423(+) CTGCCC/TGCCTT 2 -- us2k10--------
    rs1178004431,2
    C,F--31482455(+) TATAGG/ATGTGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs575107231,2
    C,F--31482528(+) TGATAC/ATCACA 3 -- us2k12Minor allele frequency- A:0.08WA 120

    HapMap Linkage Disequilibrium report for TGFB1I1 (31482906 - 31489281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TGFB1I1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TGFB1I1
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFB1I1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602353    OMIM disorders: --

    16 diseases for TGFB1I1:    About MalaCards
    hypertrophic scars    mesangial proliferative glomerulonephritis    proliferative glomerulonephritis    acne
    prostate cancer    glomerulonephritis    keloids    wiskott-aldrich syndrome
    azoospermia    prostatitis    endometriosis    sinusitis
    ataxia    endotheliitis    alzheimer's disease    breast cancer


    TGFB1I1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for TGFB1I1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 48 24 12858356 (9), 11501969 (2), 12700349 (2), 10075738 (2) (see all 7)
    necrosis 0 2 11489729 (2)
    tumors 0 7 11489729 (2), 10075738 (1), 7929412 (1), 17364555 (1) (see all 5)
    cancer 0 2 17364555 (1), 11489729 (1)


    Export disorders for TGFB1I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TGFB1I1 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with TGFB1I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PubMed id 9422762)1, 2, 3, 9 Matsuya M.... Sasaki T. (J. Biol. Chem. 1998)
    2. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PubMed id 10075738)1, 2, 3, 9 Fujimoto N....Chang C. (J. Biol. Chem. 1999)
    3. Transcriptional activation of the c-fos gene by a LIM protein, Hic- 5. (PubMed id 12445807)1, 2, 9 Kim-Kaneyama J.-R.... Nose K. (Biochem. Biophys. Res. Commun. 2002)
    4. Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. (PubMed id 15561701)1, 2, 9 Wang H.... Danielpour D. (J. Biol. Chem. 2005)
    5. Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator. (PubMed id 11856738)1, 2, 9 Wang X.... Chang C. (J. Biol. Chem. 2002)
    6. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PubMed id 16624805)1, 2, 9 Saelzler M.P....Abe M.K. (J. Biol. Chem. 2006)
    7. Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. (PubMed id 9756887)1, 2, 9 Fujita H....Tachibana K. (J. Biol. Chem. 1998)
    8. Induction of senescence-like phenotypes by forced expression of hic- 5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. (PubMed id 9032249)1, 2, 9 Shibanuma M.... Nose K. (Mol. Cell. Biol. 1997)
    9. Hic-5 regulates an epithelial program mediated by PPARgamma. (PubMed id 15687259)1, 2, 9 Drori S.... Spiegelman B.M. (Genes Dev. 2005)
    10. Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. (PubMed id 23145173)1, 2 Ryan P.E....Lipkowitz S. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7041 HGNC: 11767 AceView: TGFB1I1 Ensembl:ENSG00000140682 euGenes: HUgn7041
    ECgene: TGFB1I1 H-InvDB: TGFB1I1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TGFB1I1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFB1I1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tgfb1i1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TGFB1I1 gene:
    Search GeneIP for patents involving TGFB1I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TGFB1I1 (HIC5/TGFB1I1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TGFB1I1   OriGene RNAi products in human, mouse, rat for TGFB1I1  
     OriGene qPCR primer pairs and template standards for TGFB1I1   OriGene Protein Over-expression Lysate for TGFB1I1  
     OriGene MassSpec something-or-other for TGFB1I1   OriGene clones in human, mouse for TGFB1I1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TGFB1I1   OriGene Purified Protein for TGFB1I1  
     OriGene ORF clones in mouse, rat for TGFB1I1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TGFB1I1   OriGene Custom Protein Services for TGFB1I1  

     
     
     Block miRNA regulation of human, mouse, rat TGFB1I1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TGFB1I1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFB1I1 Predesigned siRNA for gene silencing in human, mouse, rat TGFB1I1
     QuantiFast Probe-based Assays in human, mouse, rat TGFB1I1 QuantiTect SYBR Green Assays in human, mouse, rat TGFB1I1
     PCR Arrays including human, mouse, rat TGFB1I1 Search Chromatin IP Primers for TGFB1I1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGFB1I1  GeneGlobe Interaction Network for TGFB1I1
     Regulatory tfbs in TGFB1I1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TGFB1I1 GenScript cDNA clones with any tag delivered in your preferred vector for TGFB1I1
     GenScript Custom Assay Services for TGFB1I1 GenScript Custom overexpressing Cell Line Services for TGFB1I1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TGFB1I1  (Hic-5)

     Search Tocris compounds for TGFB1I1 (TGFI1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TGFB1I1 antibodies
     TGFB1I1 proteins
     TGFB1I1 lysates
     Antibodies for TGFB1I1
     See all of Abcam's Antibodies, Kits and Proteins for TGFB1I1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TGFB1I1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFB1I1
     SwitchGear 3'UTR luciferase reporter plasmids for TGFB1I1
     SwitchGear Promoter luciferase reporter plasmids for TGFB1I1
     ThermoFisher Antibodies for TGFB1I1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFB1I1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFB1I1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFB1I1
     LSBio Antibodies in human, mouse, rat for TGFB1I1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TGFB1I1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4