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Aliases for TGFB1I1 Gene

Aliases for TGFB1I1 Gene

  • Transforming Growth Factor Beta 1 Induced Transcript 1 2 3 5
  • Androgen Receptor-Associated Protein Of 55 KDa 3 4
  • Androgen Receptor Coactivator 55 KDa Protein 3 4
  • Hydrogen Peroxide-Inducible Clone 5 Protein 3 4
  • Hydrogen Peroxide-Inducible Clone-5 2 3
  • HIC-5 3 4
  • ARA55 3 4
  • Androgen Receptor Coactivator ARA55 3
  • TSC-5 3
  • HIC5 3

External Ids for TGFB1I1 Gene

Previous GeneCards Identifiers for TGFB1I1 Gene

  • GC16P030566
  • GC16P031981
  • GC16P031480
  • GC16P031519
  • GC16P031390
  • GC16P029043

Summaries for TGFB1I1 Gene

Entrez Gene Summary for TGFB1I1 Gene

  • This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for TGFB1I1 Gene

TGFB1I1 (Transforming Growth Factor Beta 1 Induced Transcript 1) is a Protein Coding gene. Diseases associated with TGFB1I1 include prostate cancer. Among its related pathways are Adhesion and Androgen Signaling. GO annotations related to this gene include transcription coactivator activity and I-SMAD binding. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for TGFB1I1 Gene

  • Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Gene Wiki entry for TGFB1I1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFB1I1 Gene

Genomics for TGFB1I1 Gene

Regulatory Elements for TGFB1I1 Gene

Enhancers for TGFB1I1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TGFB1I1 on UCSC Golden Path with GeneCards custom track

Promoters for TGFB1I1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TGFB1I1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TGFB1I1 Gene

Chromosome:
16
Start:
31,471,585 bp from pter
End:
31,477,960 bp from pter
Size:
6,376 bases
Orientation:
Plus strand

Genomic View for TGFB1I1 Gene

Genes around TGFB1I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGFB1I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGFB1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFB1I1 Gene

Proteins for TGFB1I1 Gene

  • Protein details for TGFB1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43294-TGFI1_HUMAN
    Recommended name:
    Transforming growth factor beta-1-induced transcript 1 protein
    Protein Accession:
    O43294
    Secondary Accessions:
    • B2R8D5
    • Q9BPW3
    • Q9Y2V5

    Protein attributes for TGFB1I1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49814 Da
    Quaternary structure:
    • Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.
    SequenceCaution:
    • Sequence=AAH32545.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TGFB1I1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGFB1I1 Gene

Proteomics data for TGFB1I1 Gene at MOPED

Post-translational modifications for TGFB1I1 Gene

  • Phosphorylated by gonadotropin-releasing hormone-activated SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for TGFB1I1 (HIC5/TGFB1I1)
  • Cell Signaling Technology (CST) Antibodies for TGFB1I1 (Hic-5)
  • Cloud-Clone Corp. Antibodies for TGFB1I1

No data available for DME Specific Peptides for TGFB1I1 Gene

Domains & Families for TGFB1I1 Gene

Gene Families for TGFB1I1 Gene

Protein Domains for TGFB1I1 Gene

Suggested Antigen Peptide Sequences for TGFB1I1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43294

UniProtKB/Swiss-Prot:

TGFI1_HUMAN :
  • The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
  • Belongs to the paxillin family.
Domain:
  • The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
  • The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
  • Contains 4 LIM zinc-binding domains.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with TGFB1I1: view

Function for TGFB1I1 Gene

Molecular function for TGFB1I1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TNF and hydrogen peroxide.

Gene Ontology (GO) - Molecular Function for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9756887
GO:0050681 androgen receptor binding NAS 15572661
GO:0070411 I-SMAD binding IPI 18762808
genes like me logo Genes that share ontologies with TGFB1I1: view
genes like me logo Genes that share phenotypes with TGFB1I1: view

Animal Models for TGFB1I1 Gene

MGI Knock Outs for TGFB1I1:

Animal Model Products

CRISPR Products

miRNA for TGFB1I1 Gene

miRTarBase miRNAs that target TGFB1I1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGFB1I1 Gene

Localization for TGFB1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFB1I1 Gene

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGFB1I1 Gene COMPARTMENTS Subcellular localization image for TGFB1I1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TGFB1I1 Gene

Pathways & Interactions for TGFB1I1 Gene

genes like me logo Genes that share pathways with TGFB1I1: view

Pathways by source for TGFB1I1 Gene

1 Cell Signaling Technology pathway for TGFB1I1 Gene
1 GeneGo (Thomson Reuters) pathway for TGFB1I1 Gene
2 Qiagen pathways for TGFB1I1 Gene

Gene Ontology (GO) - Biological Process for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 10075738
GO:0007155 cell adhesion TAS 9422762
GO:0009408 response to heat IEA --
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 18762808
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TGFB1I1: view

No data available for SIGNOR curated interactions for TGFB1I1 Gene

Drugs & Compounds for TGFB1I1 Gene

(5) Drugs for TGFB1I1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TGFB1I1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TGFB1I1: view

Transcripts for TGFB1I1 Gene

Unigene Clusters for TGFB1I1 Gene

Transforming growth factor beta 1 induced transcript 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: -
SP8: - -
SP9: -
SP10: -
SP11:

Relevant External Links for TGFB1I1 Gene

GeneLoc Exon Structure for
TGFB1I1
ECgene alternative splicing isoforms for
TGFB1I1

Expression for TGFB1I1 Gene

mRNA expression in normal human tissues for TGFB1I1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGFB1I1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for TGFB1I1 Gene

This gene is overexpressed in Urinary Bladder (13.8), Bone marrow stromal cell (8.3), Prostate (8.3), and Rectum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TGFB1I1 Gene



SOURCE GeneReport for Unigene cluster for TGFB1I1 Gene Hs.513530

mRNA Expression by UniProt/SwissProt for TGFB1I1 Gene

O43294-TGFI1_HUMAN
Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).
genes like me logo Genes that share expression patterns with TGFB1I1: view

Protein tissue co-expression partners for TGFB1I1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TGFB1I1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGFB1I1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TGFB1I1 35
  • 90.13 (n)
  • 94.31 (a)
TGFB1I1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGFB1I1 35
  • 89.73 (n)
  • 93.28 (a)
TGFB1I1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgfb1i1 35
  • 87.16 (n)
  • 90.99 (a)
Tgfb1i1 16
Tgfb1i1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TGFB1I1 35
  • 99.57 (n)
  • 100 (a)
TGFB1I1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgfb1i1 35
  • 87.06 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia TGFB1I1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGFB1I1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGFB1I1 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ldb3a 36
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pax 37
  • 57 (a)
Pax 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.6 37
  • 51 (a)
pxl-1 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 36
  • 42 (a)
OneToMany
Species with no ortholog for TGFB1I1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TGFB1I1 Gene

ENSEMBL:
Gene Tree for TGFB1I1 (if available)
TreeFam:
Gene Tree for TGFB1I1 (if available)

Paralogs for TGFB1I1 Gene

(8) SIMAP similar genes for TGFB1I1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TGFB1I1: view

Variants for TGFB1I1 Gene

Sequence variations from dbSNP and Humsavar for TGFB1I1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs45475699 - 31,474,213(+) GACCA(C/G)TCTGA reference, missense
rs10596 -- 31,477,595(+) TCGCC(C/G)TCTCC utr-variant-3-prime
rs13143 -- 31,477,712(+) TGAGT(C/T)CTCAG utr-variant-3-prime
rs17552087 -- 31,471,970(+) GGCAG(A/G)CCGGC upstream-variant-2KB
rs28411344 -- 31,473,667(+) TGTGC(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGFB1I1 Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
nsv905747 CNV Gain 21882294
dgv2673n71 CNV Loss 21882294
nsv905751 CNV Loss 21882294

Variation tolerance for TGFB1I1 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TGFB1I1 Gene

HapMap Linkage Disequilibrium report
TGFB1I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFB1I1 Gene

Disorders for TGFB1I1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TGFB1I1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TGFB1I1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TGFB1I1
genes like me logo Genes that share disorders with TGFB1I1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGFB1I1 Gene

Publications for TGFB1I1 Gene

  1. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PMID: 9422762) Matsuya M. … Sasaki T. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PMID: 10075738) Fujimoto N. … Chang C. (J. Biol. Chem. 1999) 2 3 23
  3. Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. (PMID: 20448481) Caltagarone J. … Bowser R. (J. Neuropathol. Exp. Neurol. 2010) 3 23
  4. The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis. (PMID: 19389829) Aghajanova L. … Giudice L.C. (Endocrinology 2009) 3 23
  5. TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. (PMID: 17671518) Dabiri G. … Van de Water L. (J. Invest. Dermatol. 2008) 3 23

Products for TGFB1I1 Gene

Sources for TGFB1I1 Gene

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