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TGFA Gene

protein-coding GIFtS: 68

GC02M070586

transforming growth factor, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TFGA ^²

Descriptions
transforming growth factor, alpha ^²
transforming growth factor-alpha ^²

External Ids
HGNC: 11765¹
Entrez Gene: 7039²
UniProtKB: P01135³
Ensembl: ENSG00000163235⁷

Search outside databases for aliases for TGFA gene

Previous GC identifers: GC02M070683 GC02M070885 GC02M070648

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TGFA:

Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the

transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with

epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor

(MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by

OMIM]

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135

Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act

synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Gene Wiki entry for TGFA (TGF_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TGFA gene

Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13

TGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M070586: (about GC identifiers)

Start:	70,527,924 bp from pter
End:	70,634,613 bp from pter
Size:	106,690 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135 (See protein sequence)

Recommended Name: Protransforming growth factor alpha precursor

Size: 160 amino acids; 17006 Da

Subunit: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is

required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form

(i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi

apparatus, may form a complex with CNIH and GORASP2

Subcellular location: Transforming growth factor alpha: Secreted, extracellular space

Subcellular location: Protransforming growth factor alpha: Cell membrane; Single-pass type I

membrane protein

PDB structures from and Proteopedia :

1GK5 (3D)

1MOX (3D)

1YUF (3D)

1YUG (3D)

2TGF (3D)

3TGF (3D)

4TGF (3D)

Secondary accessions: Q15577

REFSEQ proteins (2 alternative transcripts):

NP_001093161.1 NP_003227.1

ENSEMBL proteins:

ENSP00000295400 ENSP00000377787

Human Recombinant Proteins

	Invitrogen human recombinant proteins for TGFA
	Millipore Purified and/or Recombinant TGFA Protein
	Sigma-Aldrich Proteins for TGFA
	R&D Systems Recombinant & Natural Proteins for TGFA (TGF-alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TGF alpha)
	Human Recombinant Proteins from Abnova (TGFA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	12743035
GO:0005886	plasma membrane	NAS	10918572
GO:0009986	cell surface	IDA	12743035
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for TGFA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TGFA
	R&D Systems Antibodies for TGFA (TGF-alpha)
	Antibodies from Abcam (TGF alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TGFA)
	Novus Biologicals Antibodies for TGFA

Assays for TGFA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for TGFA (TGF-alpha) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01135

ProtoNet protein and cluster: P01135

2 Blocks protein families:

IPB001336 Type I EGF signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135

Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TGFA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TGFA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003236

Applied Biosystems Silencer® siRNAs for TGFA

Sigma-Aldrich siRNA and siRNA Panels for TGFA

Sigma-Aldrich shRNA Panels and shRNA for TGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TGFA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099691
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099691
untagged cDNA clones in CMV expression vector (see all 3): NM_001099691

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003236

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135

Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act

synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Genatlas biochemistry entry for TGFA:

transforming growth factor,alpha,17kDa,expressed in macrophages,brain cells,keratinocyte,also

expressed at high levels in the epithelial tissue of the medial edge of the palatal shelves at the

time of shelf fusion in mice,epidermal growth factor family,involved in mitogenesis and

angiogenenesis,potentially mutated in cleft lip with or without cleft palate

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tgfa):

	adipose tissue	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	immune system	muscle	reproductive system	skeleton
skin/coat/nails	touch/vibrissae	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IEA	--
GO:0004708	MAP kinase kinase activity	IDA	11278323
GO:0004871	signal transducer activity	TAS	2103501 10918572
GO:0008083	growth factor activity	IDA	11278323

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for TGFA (Your Favorite Gene powered by Ingenuity)

NF-&kappa
Renal Cell Carcinoma Signaling
Neuregulin Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Non-Small Cell Lung Cancer Signaling

GeneDecks TGFA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TGFA

5/104 Interacting proteins for TGFA (ENSP00000295400³ P01135^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 104 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKD2	Q969F2¹	EBI-1034374, EBI-1538629
MAGI2	Q86UL8²	MINT-1894829
EGFR	ENSP00000275493³	STRING (score=.999)
ERBB2	ENSP00000269571³	STRING (score=.996)
AREGB	ENSP00000370227³	STRING (score=.978)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	11278323
GO:0001525	angiogenesis	IEA	--
GO:0008283	cell proliferation	TAS	10861448
GO:0045741	positive regulation of epidermal growth factor receptor activity	IDA	11278323
GO:0045840	positive regulation of mitosis	IDA	11278323

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TGFA
10/39 Novoseek chemical compound relationships for TGFA gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	68.20	150	1572907 (5), 7980404 (4), 9716460 (2), 2302227 (2) (see all 92)
thymidine	56.89	52	1717146 (3), 8033155 (2), 7714549 (2), 11466216 (2) (see all 34)
tab-2	54.99	6	16879932 (1), 7507364 (1), 10891104 (1), 17073730 (1) (see all 5)
bibx-1382bs	52.10	1	11178955 (1)
tgf beta1	51.83	29	14627647 (6), 10598907 (3), 10928772 (3), 16139244 (2) (see all 12)
hrgbeta1	49.07	3	15714117 (2), 17237269 (1)
exotoxin-a	48.93	12	8501821 (2), 1512230 (2), 2352944 (1), 8826849 (1) (see all 7)
progesterone	47.54	62	8624430 (5), 2064983 (3), 7672457 (3), 2173938 (3) (see all 32)
estradiol	45.18	60	1319834 (8), 8297814 (3), 9184775 (3), 2334912 (2) (see all 29)
pertuzumab	43.00	2	15503865 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TGFA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TGFA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003236

Sigma-Aldrich siRNA and siRNA Panels for TGFA

Sigma-Aldrich shRNA Panels and shRNA for TGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099691 NM_003236

REFSEQ mRNAs for TGFA gene (2 alternative transcripts):

NM_001099691.1 NM_003236.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099691 NM_003236

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099691
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099691
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001099691

Additional cDNA sequence:

AF149096.1 AF149097.1 AF149098.1 AK290151.1 AK309066.1 AK309220.1 AK312899.1 AY548763.1

BC005308.1 BT006833.1 K03222.1 M31172.1 X70340.1

3 DOTS entries:

DT.409431 DT.92422695 DT.120952753

24/68 AceView cDNA sequences (see all 68 ):

AI858901 AW340378 AV727156 BX093407 BQ942216 BC005308 AL698738 AY548763

BU728692 BI760767 M31172 BV206634 AI347589 T27592 BT006833 BG741780

NM_003236 BM663384 AI167705 BI964715 BE925944 AF149096 BG740369 BF062540

highest scoring ESTs for TGFA:

X70340 AF149096 AF149097 AF149098 AL698738 BT006833 K03222 M31172 BC005308 AA037107

Unigene Cluster for TGFA:

Transforming growth factor, alpha

Hs.170009 [show with all ESTs]

Unigene Representative Sequence: NM_003236

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TGFA (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11
SP1:							-		-				-		-												-
SP2:							-		-				-		-												-
SP3:							-		-				-		-												-		-		-
SP4:							-		-				-		-
SP5:							-		-				-		-												-		-		-

About this scheme

ECgene alternative splicing isoforms for TGFA

2 Ensembl transcripts including schematic representations:

ENST00000295400 ENST00000394241

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TGFA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TGFA

¹ / ² / ³

7 probe-sets matching TGFA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
160025_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X70340	1.00	1.00	1.00	1
211258_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF149096	0.80	1.00	0.91	1
205016_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003236	0.60	1.00	0.82	1
205015_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M31172	0.80	1.00	0.91	1
211258_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205016_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205015_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TGFA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.170009
Expression variation in blood from EXPOLDB for TGFA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TGFA gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TGFA¹	--	transforming growth factor, alpha	88.71(n) 95.28(a)	403431 XM_850397.1 XP_855490.1
chimpanzee (Pan troglodytes)	TGFA¹	--	transforming growth factor, alpha	99.58(n) 100(a)	737080 XM_001142892.1 XP_001142892.1
rat (Rattus norvegicus)	Tgfa¹	--	transforming growth factor alpha	87.63(n) 93.08(a)	24827 NM_012671.1 NP_036803.1
mouse (Mus musculus)	Tgfa^{1, 5}	6 (35.80 cM)⁵	transforming growth factor alpha^{1, 5}	88.47(n)¹ 92.45(a)¹	21802¹ NM_031199.2¹ NP_112476.1¹ AK010785⁵ AK162680⁵ (see all 13)
chicken (Gallus gallus)	TGFA¹	--	transforming growth factor, alpha	78.16(n) 82.76(a)	414743 XM_001234467.1 XP_001234468.1

About this table Species with no ortholog for TGFA

ENSEMBL Gene Tree for TGFA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TGFA gene

BTC² C9orf30² TMEFF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/839 NCBI SNPs in TGFA are shown (see all 839 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 324)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1058213^1,2	A,C,F,H	70530971(-)	`GAGACC/TCTCAA`	2	--	ut3¹ ese³		4	NA EU WA	214
	rs538118^1,2	C,F,H,O	70530147(+)	`GCCCCA/GTGGGT`	2	--	ut3¹ ese³		11	EA NA EU WA	658
	rs473698^1,2	C,F,H,O	70529089(+)	`CAATTC/GATTTT`	2	--	ut3¹		30	MN EA NA EU NS WA	3698
	rs3771523^1,2	A,C,F	70530976(-)	`ACCACG/AAGACC`	2	--	ut3¹ ese³		3	NA EU	94
	rs11466304^1,2	C,F,H	70527741(-)	`TCCCAG/TTGTAT`	2	--	ng5¹		11	NA EU EA WA	928
	rs3732253^1,2	C,F,H	70529606(-)	`ATCAAC/TGGACA`	2	--	ut3¹ ese³		12	EA NA EU WA	2221
	rs11466285^1,2	C,F,H	70530947(-)	`TTCCAT/CGGACA`	2	--	ut3¹		10	NA EU EA WA	624
	rs11466297^1,2	C,F,H	70529215(-)	`ATTGGA/CTCCCT`	2	--	ut3¹ ese³		14	NA EU EA WA	1058
	rs503314^1,2	C,F,H	70528257(+)	`ACTAAG/CAAGAG`	2	--	ut3¹ trp³		16	MN NA EU NS EA WA	938
	rs11466259^1,2	C,F,H	70537019(-)	`CCATCG/ATGGCC`	2	M/V	mis¹ ese³		12	NA EU EA WA	1006

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HapMap Linkage Disequilibrium images for TGFA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 190170

10/97 Novoseek disease relationships for TGFA gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	70.33	904	11727256 (8), 1746909 (5), 1519669 (5), 7687782 (5) (see all 99)
menetrier disease	64.87	35	1451986 (5), 8636814 (5), 8522306 (4), 15887112 (3) (see all 9)
cholesteatoma middle ear	62.49	8	8817015 (2), 8369082 (1), 12725186 (1), 11078065 (1)
cleft lip	60.79	72	18788876 (3), 9003904 (3), 17334078 (3), 15449618 (3) (see all 34)
carcinoma squamous cell	60.43	105	9828815 (5), 8843456 (4), 1863074 (3), 9625170 (3) (see all 53)
cleft palate	59.59	60	15449618 (3), 8105683 (3), 17334078 (3), 10552925 (2) (see all 26)
breast cancer	59.38	180	8508397 (5), 1912611 (4), 10668644 (4), 8137282 (3) (see all 89)
colon carcinoma	57.71	61	8014008 (4), 8398905 (4), 11973637 (3), 9935234 (3) (see all 28)
carcinoma	57.51	187	8523820 (5), 9542514 (4), 8371007 (4), 8625090 (3) (see all 99)
hyperplasia	56.62	80	10233260 (2), 10708482 (2), 8371007 (2), 12607604 (2) (see all 51)

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Genetic Association Database: TGFA
Human Genome Epidemiology Navigator: TGFA (29 documents)
Tumor Gene Database: TGFA
Breast Cancer Gene Database: TGFA

(Possibly Related Articles in Doctor's Guide)
About This Section

FDA Grants Fast Track Designation for Panitumumab for Treatment of Metastatic Colorectal Cancer

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1842 PubMed articles for TGFA gene (see all 1842 ):

Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. (PubMed id 10552925)^{1, 2, 3, 4} Machida J....Murray J.C. (1999)
[The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate] (PubMed id 15449618)^{1, 3, 6} Zhang W.G....Liang J. (2004)
Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate in Brazilian patients: results of a large case-control study. (PubMed id 15222785)^{1, 3, 6} Passos-Bueno M.R....Araujo B. (2004)
Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. (PubMed id 8100397)^{1, 3, 4} Qian J.F.... May E. (1993)
Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. (PubMed id 15643916)^{1, 3, 6} Zeiger J.S....Liang K.Y. (2005)
[Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population] (PubMed id 16311697)^{1, 3, 6} Suazo J....Blanco R. (2005)
Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico. (PubMed id 15864136)^{3, 6} Kang D....Hayes R.B. (2005)
Genotyping for cytokine polymorphisms: allele frequencies in the Italian population. (PubMed id 12558814)^{3, 6} Uboldi de Capei M.U....Curtoni E.S. (2003)
Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis. (PubMed id 12652527)^{3, 6} Jugessur A....Abyholm F. (2003)
A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. (PubMed id 10230395)^{3, 4} Fernandez-Larrea J....Arribas J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7039	HGNC: 11765	AceView: TGFA	Ensembl:ENSG00000163235	euGenes: HUgn7039
ECgene: TGFA	H-InvDB: TGFA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TGFA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TGFA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TGFA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TGFA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TGFA		Antibodies for TGFA
	Explore super-pooled esiRNAs		Proteins for TGFA
	Lentivirus-delivered shRNAs for TGFA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TGFA)
	Antibodies (TGFA)
	Chimera RNAi (TGFA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TGF alpha)
	Antibodies (TGF alpha)

Search OriGene for TGFA

Search Tocris compounds for TGFA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TGFA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TGFA Gene at Home site.
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TGFA Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for TGFA

Summaries
for TGFA

Genomic Location
for TGFA

Proteins
for TGFA

Protein Domains/
Families
for TGFA

Gene Function
for TGFA

Pathways & Interactions
for TGFA

Drugs & Compounds
for TGFA

Transcripts
for TGFA

Expression
for TGFA

Orthologs
for TGFA

Paralogs
for TGFA

SNPs/Variants
for TGFA

Disorders & Mutations
for TGFA

Medical News
for TGFA

Publications
for TGFA

Search for TGFA

Genome Databases showing TGFA

Other Databases showing TGFA

Specialized Databases showing TGFA

Licensable Technologies
for TGFA

Services
for TGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TGFA Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor TGFA

Summariesfor TGFA

Genomic Locationfor TGFA

Proteinsfor TGFA

Protein Domains/Familiesfor TGFA

Gene Functionfor TGFA

Pathways & Interactionsfor TGFA

Drugs & Compoundsfor TGFA

Transcriptsfor TGFA

Expression for TGFA

Orthologsfor TGFA

Paralogsfor TGFA

SNPs/Variantsfor TGFA

Disorders & Mutationsfor TGFA

Medical Newsfor TGFA

Publicationsfor TGFA

Search for TGFA

Genome Databases showing TGFA

Other Databases showing TGFA

Specialized Databases showing TGFA

Licensable Technologiesfor TGFA

Servicesfor TGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TGFA

Summaries
for TGFA

Genomic Location
for TGFA

Proteins
for TGFA

Protein Domains/
Families
for TGFA

Gene Function
for TGFA

Pathways & Interactions
for TGFA

Drugs & Compounds
for TGFA

Transcripts
for TGFA

Expression
for TGFA

Orthologs
for TGFA

Paralogs
for TGFA

SNPs/Variants
for TGFA

Disorders & Mutations
for TGFA

Medical News
for TGFA

Publications
for TGFA

Licensable Technologies
for TGFA

Services
for TGFA