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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TGFA Gene

protein-coding   GIFtS: 64
GCID: GC02M070674

Transforming Growth Factor, Alpha

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transforming Growth Factor, Alpha1 2
TFGA2
TGF-alpha2
Protransforming Growth Factor Alpha2

External Ids:    HGNC: 117651   Entrez Gene: 70392   Ensembl: ENSG000001632357   OMIM: 1901705   UniProtKB: P011353   

Export aliases for TGFA gene to outside databases

Previous GC identifers: GC02M070683 GC02M070885 GC02M070648 GC02M070586 GC02M070410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TGFA Gene:
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a
signaling pathway for cell proliferation, differentiation and development. This protein may act as either a
transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it
may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for TGFA Gene: 
TGFA (transforming growth factor, alpha) is a protein-coding gene. Diseases associated with TGFA include bone marrow necrosis, and bronchiolo-alveolar adenocarcinoma, and among its related super-pathways are ErbB signaling pathway and Rac1 Pathway. GO annotations related to this gene include epidermal growth factor receptor binding and growth factor activity. An important paralog of this gene is BTC.

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act
synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Gene Wiki entry for TGFA (TGF alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TGFA gene promoter:
         p53   Evi-1   c-Ets-1   NF-AT   NF-AT4   FOXC1   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFA promoter sequence
   Search SABiosciences Chromatin IP Primers for TGFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13

TGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M070674:  view genomic region     (about GC identifiers)

Start:
70,674,412 bp from pter      End:
70,781,325 bp from pter
Size:
106,914 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135 (See protein sequence)
Recommended Name: Protransforming growth factor alpha precursor  
Size: 160 amino acids; 17006 Da
Subunit: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the
targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and
lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and
GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2
Subcellular location: Transforming growth factor alpha: Secreted, extracellular space
Subcellular location: Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein
6/8 PDB 3D structures from and Proteopedia for TGFA (see all 8):
1GK5 (3D)        1MOX (3D)        1YUF (3D)        1YUG (3D)        2TGF (3D)        3E50 (3D)    
Secondary accessions: A8K286 Q15577 Q53SK7 Q9BS56 Q9UEI3 Q9UKM1 Q9UKM2 Q9UKM3
Alternative splicing: 5 isoforms:  P01135-1   P01135-2   P01135-3   P01135-4   P01135-5   

Explore the universe of human proteins at neXtProt for TGFA: NX_P01135

Explore proteomics data for TGFA at MOPED 

TGFA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TGFA Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001093161.1  NP_003227.1  

ENSEMBL proteins: 
 ENSP00000295400   ENSP00000407432   ENSP00000387493   ENSP00000404099   ENSP00000414127  
 ENSP00000404131   ENSP00000377787  

Human Recombinant Protein Products for TGFA: 
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Novus Biologicals TGFA Lysates
Sino Biological Recombinant Protein for TGFA
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA12743035
GO:0005634nucleus IEA--
GO:0005886plasma membrane NAS10918572
GO:0009986cell surface IDA12743035
GO:0016021integral to membrane IEA--

TGFA for ontologies           About GeneDecksing



TGFA Antibody Products: 
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Assay Products for TGFA: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR015497 EGF_rcpt_ligand
 IPR000742 EG-like_dom
 IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry P01135

ProtoNet protein and cluster: P01135

2 Blocks protein domains:
IPB001336 Type I EGF signature
IPB006210 Type I EGF


UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
Similarity: Contains 1 EGF-like domain


TGFA for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TGFA_HUMAN, P01135
Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act
synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

     Genatlas biochemistry entry for TGFA:
transforming growth factor,alpha,17kDa,expressed in macrophages,brain cells,keratinocyte,also expressed at high
levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in
mice,epidermal growth factor family,involved in mitogenesis and angiogenenesis,potentially mutated in cleft lip
with or without cleft palate

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001948glycoprotein binding IEA--
GO:0004708MAP kinase kinase activity IDA11278323
GO:0005154epidermal growth factor receptor binding IDA11278323
GO:0005515protein binding IPI15064403
GO:0008083growth factor activity IDA11278323
     
TGFA for ontologies           About GeneDecksing


Phenotypes:
     12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tgfa):
 adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
 growth/size  immune system  integument  muscle  reproductive system 
 skeleton  vision/eye 

TGFA for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TGFA: Tgfatm1Ard Tgfatm1Unc

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TGFA 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TGFA

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGFA 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGFA 

miRNA
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hsa-miR-323-3p hsa-miR-2052 hsa-miR-301a hsa-miR-374a hsa-miR-759 hsa-miR-34b hsa-miR-23a hsa-miR-3148
SwitchGear 3'UTR luciferase reporter plasmidTGFA 3' UTR sequence
Inhib. RNA
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Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): TGFA (NM_003236)
Sino Biological Human cDNA Clone for TGFA
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFA
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFA
Sirion Biotech Customized lentivirus for stable overexpression of TGFA 
                     Customized lentivirus expression plasmids for stable overexpression of TGFA 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFA


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TGFA About   (see all 25)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1ErbB signaling pathway
ErbB signaling pathway0.52
EGFR Inhibitor Pathway, Pharmacodynamics0.49
ErbB signaling pathway0.52
2Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
3GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
4Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
5Nanog in Mammalian ESC Pluripotency
Nanog in Mammalian ESC Pluripotency0.61
14-3-3 Induced Intracellular Signaling0.59
GSK3 Signaling0.61
eNOS Signaling0.48

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for TGFA
    Development ERBB-family signaling
Development EGFR signaling pathway

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TGFA (see all 55)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TGFA
    Angiogenesis
Tyrosine Kinases / Adaptors

3 GeneGo (Thomson Reuters) Pathways for TGFA
    Development ERBB-family signaling
Mucin expression in CF via TLRs, EGFR signaling pathways
Development EGFR signaling pathway

4 BioSystems Pathways for TGFA
    ErbB signaling pathway
ErbB receptor signaling network
Direct p53 effectors
FOXM1 transcription factor network


1 PharmGKB Pathway for TGFA
    EGFR Inhibitor Pathway, Pharmacodynamics

5/7         Kegg Pathways  (Kegg details for TGFA) (see all 7):
    ErbB signaling pathway
Pathways in cancer
Renal cell carcinoma
Pancreatic cancer
Glioma


TGFA for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TGFA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for TGFA (P011352, 3 ENSP000002954004) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
InteractantInteraction Details
GeneCardExternal ID(s)
MAGI2Q86UL82, 3, ENSP000003461514MINT-1894829 I2D: score=2 STRING: ENSP00000346151
MAGI3Q5TCQ92, 3, ENSP000003046044MINT-1894801 I2D: score=3 STRING: ENSP00000304604
NKD2Q969F23, ENSP000002968494I2D: score=3 STRING: ENSP00000296849
GORASP1Q9BQQ33, ENSP000003138694I2D: score=2 STRING: ENSP00000313869
ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000165MAPK cascade IDA11278323
GO:0000187activation of MAPK activity IDA11278323
GO:0001525angiogenesis IEA--
GO:0007173epidermal growth factor receptor signaling pathway IEA--
GO:0008283cell proliferation TAS10861448

TGFA for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TGFA for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TGFA

10/139 Novoseek inferred chemical compound relationships for TGFA gene (see all 139)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ag 1478 73.4 11 15355899 (1), 10722725 (1), 11178955 (1), 12600830 (1) (see all 9)
pd153035 72.5 4 8980296 (1), 16443372 (1), 11178955 (1)
tyrosine 68.5 153 1572907 (5), 7980404 (4), 9716460 (2), 2302227 (2) (see all 94)
gefitinib 64.9 34 16230376 (5), 11350918 (4), 16585207 (4), 16568376 (2) (see all 11)
8-chloro-camp 60.1 5 1850725 (1), 9815703 (1), 8381655 (1), 14691008 (1)
vegf 59.7 244 18685072 (7), 19628074 (6), 15379270 (5), 10938383 (5) (see all 99)
estrogen 57.9 151 7720660 (8), 9605408 (4), 11698343 (4), 8360257 (3) (see all 61)
thymidine 56.9 53 1717146 (3), 8033155 (2), 7714549 (2), 11466216 (2) (see all 35)
cetuximab 53.5 11 19276250 (3), 16806963 (1), 16675911 (1), 20047592 (1) (see all 5)
tgf beta1 53 29 14627647 (6), 10598907 (3), 10928772 (3), 16139244 (2) (see all 12)

Search CenterWatch for drugs/clinical trials and news about TGFA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TGFA gene (2 alternative transcripts): 
NM_001099691.2  NM_003236.3  

Unigene Cluster for TGFA:

Transforming growth factor, alpha
Hs.170009  [show with all ESTs]
Unigene Representative Sequence: NM_003236
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000295400(uc010fdq.3 uc010fdr.3 uc002sgs.4 uc002sgt.4 uc002sgu.3 uc002sgv.3 uc002sgw.3)
ENST00000419940 ENST00000445399 ENST00000418333 ENST00000450929 ENST00000444975
ENST00000394241 ENST00000460808 ENST00000474101
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate TGFA (see all 53):
hsa-miR-323-3p hsa-miR-2052 hsa-miR-301a hsa-miR-374a hsa-miR-759 hsa-miR-34b hsa-miR-23a hsa-miR-3148
SwitchGear 3'UTR luciferase reporter plasmidTGFA 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFA
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFA
Sirion Biotech Customized lentivirus for stable overexpression of TGFA 
                     Customized lentivirus expression plasmids for stable overexpression of TGFA 
Primer
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OriGene qPCR primer pairs and template standards for TGFA
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGFA
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGFA

Additional mRNA sequence: 

AF149096.1 AF149097.1 AF149098.1 AK290151.1 AK309066.1 AK309220.1 AK312899.1 AY548763.1 
BC005308.1 BT006833.1 K03222.1 M31172.1 X70340.1 

3 DOTS entries:

DT.409431  DT.92422695  DT.120952753 

24/68 AceView cDNA sequences (see all 68):

BI760767 AY548763 AI858901 AV727156 AL698738 BX093407 BU728692 AW340378 
BQ942216 BC005308 AI206396 BM453873 AF149097 BM663384 NM_003236 BQ440808 
CD369689 M31172 AI347589 BT006833 AI801669 T27592 AI167705 AA933077 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TGFA (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1:                    -     -           -     -                                   -                     
SP2:                    -     -           -     -                                   -                     
SP3:                    -     -           -     -                                   -     -     -         
SP4:                    -     -           -     -                                                         
SP5:                    -     -           -     -                                   -     -     -         


ECgene alternative splicing isoforms for TGFA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TGFA expression in normal human tissues (normalized intensities)      TGFA embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TGFA Expression
About this image


TGFA expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/18 selected tissues (see all 18) fully expand
 
 Epithelium
         Human Renal Epithelial Cells (HREpiC)   
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Striatum
         brain/midbrain   
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote
 
 Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote

See TGFA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGFA

SOURCE GeneReport for Unigene cluster: Hs.170009

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines

    SABiosciences Expression via Pathway-Focused PCR Arrays including TGFA (see all 9): 
          Growth Factors in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Wound Healing in human mouse rat
          Liver Cancer in human mouse rat
          Angiogenesis in human mouse rat

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TGFA gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tgfa1 , 5 transforming growth factor alpha1, 5 88.47(n)1
92.45(a)1
  6 (37.62 cM)5
218021  NM_031199.31  NP_112476.11 
 861952515 
chicken
(Gallus gallus)
Aves TGFA1 transforming growth factor, alpha 74.89(n)
74.03(a)
  414743  NM_001001614.1  NP_001001614.1 
zebrafish
(Danio rerio)
Actinopterygii tgfa1 transforming growth factor, alpha 64.17(n)
57.94(a)
  100034402  NM_001144052.1  NP_001137524.1 


ENSEMBL Gene Tree for TGFA (if available)
TreeFam Gene Tree for TGFA (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TGFA gene
BTC2  
5 SIMAP similar genes for TGFA using alignment to 8 protein entries:     TGFA_HUMAN (see all proteins):
EGF    BTC    MSANTD3-TMEFF1    EPGN    NRG4

TGFA for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/2376 SNPs in TGFA are shown (see all 2376)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1477169721,2
Cuntested170609360(+) AGTTAA/C/GCACAG 2 -- int10--------
rs1504146531,2
C--70433917(+) GAGAA-/GGAGAGA 2 -- int10--------
rs1998003721,2
--70468319(+) TATAT-/ATATATATA
TATATATATAC
ACACA
2 -- int10--------
rs2007331431,2
C--70468321(+) TATAT-/ATATATAT
ATATATATAC
ACACA
2 -- int10--------
rs724061071,2
C--70475773(+) GAATA-/AC    
   
/ACAC
CACAC
2 -- int11CSA 2
rs349552241,2
C--70484303(+) GAGGA-/CGGAGA 2 -- int10--------
rs134216421,2
A--70485495(+) TTGTTG/TGtttg 2 -- int10--------
rs612928401,2
C--70498594(+) TTTAT-/GATATTTC 2 -- cds10--------
rs1143554461,2
C,F--70539960(+) CAAAGA/TTTTGC 2 -- ds50011Minor allele frequency- T:0.11WA 118
rs114663071,2
C,F,H--70539980(-) CCTGTG/AAACTT 2 -- ds500119Minor allele frequency- A:0.04NA EU NS EA WA 2144

HapMap Linkage Disequilibrium report for TGFA (70674412 - 70781325 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TGFA:    About this table     
Variant IDTypeSubtypePubMed ID
nsv834255CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 190170    OMIM disorders: --

20/188 diseases for TGFA (see all 188):    About MalaCards
bone marrow necrosis    bronchiolo-alveolar adenocarcinoma    nonpapillary renal cell carcinoma    embryonal cancer
ovarian cystadenoma    warthin tumor    esophagus adenocarcinoma    alstrom syndrome
hypothalamic hamartomas    cholesteatoma    cleft lip    cleft palate
leukoplakia    acanthosis nigricans    chorioretinitis    chronic leukemia
cleidocranial dysplasia    oral leukoplakia    asbestosis    central precocious puberty

3 diseases from the University of Copenhagen DISEASES database for TGFA:
Cleft lip     Cleft palate     Tooth agenesis

TGFA for disorders           About GeneDecksing

10/97 Novoseek inferred disease relationships for TGFA gene (see all 97)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 70.4 926 11727256 (8), 1746909 (5), 1519669 (5), 7687782 (5) (see all 99)
menetrier disease 64.4 35 1451986 (5), 8636814 (5), 8522306 (4), 15887112 (3) (see all 9)
cholesteatoma middle ear 61.7 8 8817015 (2), 8369082 (1), 12725186 (1), 11078065 (1)
cleft lip 61.3 76 18788876 (3), 9003904 (3), 15449618 (3), 17334078 (3) (see all 36)
cleft palate 60.4 62 15449618 (3), 8105683 (3), 17334078 (3), 10552925 (2) (see all 28)
carcinoma squamous cell 59.6 106 9828815 (5), 8843456 (4), 1863074 (3), 9625170 (3) (see all 54)
breast cancer 58.7 185 8508397 (5), 1912611 (4), 10668644 (4), 8137282 (3) (see all 90)
colon carcinoma 57.3 62 8014008 (4), 8398905 (4), 11973637 (3), 9935234 (3) (see all 29)
carcinoma 56.9 189 8523820 (5), 9542514 (4), 8371007 (4), 8625090 (3) (see all 99)
hyperplasia 56.1 80 10233260 (2), 10708482 (2), 8371007 (2), 12607604 (2) (see all 51)

Genetic Association Database (GAD): TGFA
Human Genome Epidemiology (HuGE) Navigator: TGFA (44 documents)
Tumor Gene Database (TGDB): TGFA

Export disorders for TGFA gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TGFA gene, integrated from 9 sources (see all 2062):
(articles sorted by number of sources associating them with TGFA)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. (PubMed id 10552925)1, 2, 3, 9 Machida J....Murray J.C. (1999)
  2. TGFA/TAQ I polymorphism in nonsyndromic cleft lip and palate patients from Rio Grande Do Sul, Brazil. (PubMed id 18788876)1, 4, 9 Ehlers Bertoja A....Miriam Robinson W. (2008)
  3. [Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate] (PubMed id 17334078)1, 4, 9 Yuan K.F....Zhou X.H. (2006)
  4. [The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate] (PubMed id 15449618)1, 4, 9 Zhang W.G....Liang J. (2004)
  5. Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia. (PubMed id 18956930)1, 4, 9 Rahman R.A....Samsudin A.R. (2008)
  6. Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. (PubMed id 8100397)1, 2, 9 Qian J.F.... May E. (1993)
  7. Epidermal growth factor receptor intron 1 CA dinucleo tide repeat polymorphism and survival of advanced gastric cancer patients treat ed with cetuximab plus modified FOLFOX6. (PubMed id 20047592)1, 4, 9 Han S.W....Kim T.Y. (2010)
  8. MTHFR, TGFB3, and TGFA polymorphisms and their associ ation with the risk of non-syndromic cleft lip and cleft palate in China. (PubMed id 20082468)1, 4, 9 Zhu J....Li Z. (2010)
  9. Evidence that TGFA influences risk to cleft lip with/ without cleft palate through unconventional genetic mechanisms. (PubMed id 19444471)1, 4, 9 Sull J.W....Beaty T.H. (2009)
  10. [Association between parental transforming growth factor alpha gene TaqI variant, paternal smoking and the cleft lip with or without cleft palate] (PubMed id 17313741)1, 4, 9 Zhu J.H....Li Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7039 HGNC: 11765 AceView: TGFA Ensembl:ENSG00000163235 euGenes: HUgn7039
ECgene: TGFA Kegg: 7039 H-InvDB: TGFA

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TGFA Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TGFA Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TGFA gene:
Search GeneIP for patents involving TGFA

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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