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Aliases for TGFA Gene

Aliases for TGFA Gene

  • Transforming Growth Factor, Alpha 2 3
  • Protransforming Growth Factor Alpha 3
  • TGF-Alpha 3
  • TFGA 3

External Ids for TGFA Gene

Summaries for TGFA Gene

Entrez Gene Summary for TGFA Gene

  • This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for TGFA Gene

TGFA (Transforming Growth Factor, Alpha) is a Protein Coding gene. Diseases associated with TGFA include bone marrow necrosis and renal cell carcinoma. Among its related pathways are Pathways in cancer and NF-KappaB Family Pathway. GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is BTC.

UniProtKB/Swiss-Prot for TGFA Gene

  • TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Gene Wiki entry for TGFA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFA Gene

Genomics for TGFA Gene

Genomic Location for TGFA Gene

Start:
70,447,280 bp from pter
End:
70,554,193 bp from pter
Size:
106,914 bases
Orientation:
Minus strand

Genomic View for TGFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TGFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFA Gene

Regulatory Elements for TGFA Gene

Proteins for TGFA Gene

  • Protein details for TGFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01135-TGFA_HUMAN
    Recommended name:
    Protransforming growth factor alpha
    Protein Accession:
    P01135
    Secondary Accessions:
    • A8K286
    • Q15577
    • Q53SK7
    • Q9BS56
    • Q9UEI3
    • Q9UKM1
    • Q9UKM2
    • Q9UKM3

    Protein attributes for TGFA Gene

    Size:
    160 amino acids
    Molecular mass:
    17006 Da
    Quaternary structure:
    • Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.

    Three dimensional structures from OCA and Proteopedia for TGFA Gene

    Alternative splice isoforms for TGFA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGFA Gene

Proteomics data for TGFA Gene at MOPED

Post-translational modifications for TGFA Gene

No data available for DME Specific Peptides for TGFA Gene

Domains for TGFA Gene

Protein Domains for TGFA Gene

UniProtKB/Swiss-Prot:

TGFA_HUMAN
Domain:
  • Contains 1 EGF-like domain.:
    • P01135
genes like me logo Genes that share domains with TGFA: view

No data available for Gene Families for TGFA Gene

Function for TGFA Gene

Molecular function for TGFA Gene

GENATLAS Biochemistry: transforming growth factor,alpha,17kDa,expressed in macrophages,brain cells,keratinocyte,also expressed at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice,epidermal growth factor family,involved in mitogenesis and angiogenenesis,potentially mutated in cleft lip with or without cleft palate
UniProtKB/Swiss-Prot Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Gene Ontology (GO) - Molecular Function for TGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0005154 epidermal growth factor receptor binding IDA 11278323
GO:0005515 protein binding IPI 12297049
GO:0008083 growth factor activity IDA 11278323
genes like me logo Genes that share ontologies with TGFA: view
genes like me logo Genes that share phenotypes with TGFA: view

Animal Models for TGFA Gene

MGI Knock Outs for TGFA:

miRNA for TGFA Gene

miRTarBase miRNAs that target TGFA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TGFA Gene

Localization for TGFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFA Gene

Transforming growth factor alpha: Secreted, extracellular space.
Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TGFA Gene COMPARTMENTS Subcellular localization image for TGFA gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 12743035
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane NAS 10918572
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IDA 12743035
genes like me logo Genes that share ontologies with TGFA: view

Pathways for TGFA Gene

genes like me logo Genes that share pathways with TGFA: view

Gene Ontology (GO) - Biological Process for TGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 11278323
GO:0001525 angiogenesis IEA --
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0008283 cell proliferation TAS 10861448
GO:0008284 positive regulation of cell proliferation --
genes like me logo Genes that share ontologies with TGFA: view

Compounds for TGFA Gene

(139) Novoseek inferred chemical compound relationships for TGFA Gene

Compound -log(P) Hits PubMed IDs
ag 1478 73.4 9
pd153035 72.5 3
tyrosine 68.5 109
gefitinib 64.9 22
8-chloro-camp 60.1 4
genes like me logo Genes that share compounds with TGFA: view

Transcripts for TGFA Gene

Unigene Clusters for TGFA Gene

Transforming growth factor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TGFA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for TGFA Gene

GeneLoc Exon Structure for
TGFA
ECgene alternative splicing isoforms for
TGFA

Expression for TGFA Gene

mRNA expression in normal human tissues for TGFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGFA Gene

This gene is overexpressed in Whole Blood (4.9), Brain - Spinal cord (cervical c-1) (4.9), and Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TGFA Gene

SOURCE GeneReport for Unigene cluster for TGFA Gene Hs.170009

mRNA Expression by UniProt/SwissProt for TGFA Gene

P01135-TGFA_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
genes like me logo Genes that share expressions with TGFA: view

Orthologs for TGFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TGFA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGFA 36
  • 99.58 (n)
  • 100 (a)
TGFA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGFA 36
  • 94.58 (n)
  • 95.62 (a)
TGFA 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TGFA 36
  • 88.43 (n)
  • 93.06 (a)
TGFA 37
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tgfa 36
  • 88.47 (n)
  • 92.45 (a)
Tgfa 16
Tgfa 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TGFA 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGFA 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tgfa 36
  • 87.63 (n)
  • 93.08 (a)
chicken
(Gallus gallus)
Aves TGFA 36
  • 74.89 (n)
  • 74.03 (a)
TGFA 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485434 36
  • 70.04 (n)
  • 74.05 (a)
zebrafish
(Danio rerio)
Actinopterygii tgfa 37
  • 33 (a)
OneToOne
Species with no ortholog for TGFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TGFA Gene

ENSEMBL:
Gene Tree for TGFA (if available)
TreeFam:
Gene Tree for TGFA (if available)

Paralogs for TGFA Gene

Paralogs for TGFA Gene

Selected SIMAP similar genes for TGFA Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TGFA: view

Variants for TGFA Gene

Sequence variations from dbSNP and Humsavar for TGFA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6386 -- 70,449,638(-) TTTTT(C/T)CCTCA utr-variant-3-prime
rs365259 -- 70,532,295(-) AGAAA(A/G)CAAGA intron-variant
rs365632 -- 70,538,950(+) gttgt(C/G)ttatt intron-variant
rs370050 -- 70,535,218(-) CACCT(C/T)GGGCA intron-variant
rs373425 -- 70,541,030(+) ACGTG(C/T)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TGFA Gene

Variant ID Type Subtype PubMed ID
nsv834255 CNV Gain 17160897

Relevant External Links for TGFA Gene

HapMap Linkage Disequilibrium report
TGFA

Disorders for TGFA Gene

(3) University of Copenhagen DISEASES for TGFA Gene

(97) Novoseek inferred disease relationships for TGFA Gene

Disease -log(P) Hits PubMed IDs
tumors 70.4 269
menetrier disease 64.4 26
cholesteatoma middle ear 61.7 5
cleft lip 61.3 57
cleft palate 60.4 42

Relevant External Links for TGFA

Genetic Association Database (GAD)
TGFA
Human Genome Epidemiology (HuGE) Navigator
TGFA
Tumor Gene Database (TGDB):
TGFA
genes like me logo Genes that share disorders with TGFA: view

No data available for UniProtKB/Swiss-Prot for TGFA Gene

Publications for TGFA Gene

  1. Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. (PMID: 10552925) Machida J. … Murray J.C. (Genomics 1999) 2 3 4 23
  2. Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate in Brazilian patients: results of a large case-control study. (PMID: 15222785) Passos-Bueno M.R. … AraA_jo B. (Cleft Palate Craniofac. J. 2004) 3 23 49
  3. Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. (PMID: 15643916) Zeiger J.S. … Liang K.Y. (Cleft Palate Craniofac. J. 2005) 3 23 49
  4. [Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population]. (PMID: 16311697) Suazo J. … Blanco R. (Rev Med Chil 2005) 3 23 49
  5. Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. (PMID: 8100397) Qian J.F. … May E. (Am. J. Hum. Genet. 1993) 3 4 23

Products for TGFA Gene

Sources for TGFA Gene

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