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TGFA Gene

protein-coding   GIFtS: 65
GCID: GC02M070674

Transforming Growth Factor, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming Growth Factor, Alpha1 2
TFGA2
TGF-alpha2
Protransforming Growth Factor Alpha2

External Ids:    HGNC: 117651   Entrez Gene: 70392   Ensembl: ENSG000001632357   OMIM: 1901705   UniProtKB: P011353   

Export aliases for TGFA gene to outside databases

Previous GC identifers: GC02M070683 GC02M070885 GC02M070648 GC02M070586 GC02M070410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TGFA Gene:
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a
signaling pathway for cell proliferation, differentiation and development. This protein may act as either a
transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it
may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for TGFA Gene:
TGFA (transforming growth factor, alpha) is a protein-coding gene. Diseases associated with TGFA include tooth agenesis, selective, 1, with or without orofacial cleft, and bone marrow necrosis. GO annotations related to this gene include epidermal growth factor receptor binding and growth factor activity. An important paralog of this gene is BTC.

UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act
synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

Gene Wiki entry for TGFA (TGF alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TGFA gene promoter:
         p53   Evi-1   c-Ets-1   NF-AT   NF-AT4   FOXC1   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTGFA promoter sequence
   Search Chromatin IP Primers for TGFA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13

TGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TGFA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M070674:  view genomic region     (about GC identifiers)

Start:
70,674,412 bp from pter      End:
70,781,325 bp from pter
Size:
106,914 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135 (See protein sequence)
Recommended Name: Protransforming growth factor alpha precursor  
Size: 160 amino acids; 17006 Da
Subunit: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the
targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and
lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and
GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2
Selected PDB 3D structures from and Proteopedia for TGFA (see all 8):
1GK5 (3D)        1MOX (3D)        1YUF (3D)        1YUG (3D)        2TGF (3D)        3E50 (3D)    
Secondary accessions: A8K286 Q15577 Q53SK7 Q9BS56 Q9UEI3 Q9UKM1 Q9UKM2 Q9UKM3
Alternative splicing: 5 isoforms:  P01135-1   P01135-2   P01135-3   P01135-4   P01135-5   

Explore the universe of human proteins at neXtProt for TGFA: NX_P01135

Post-translational modifications: 

  • Glycosylation2 at Asn25
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001093161.1  NP_003227.1  

    ENSEMBL proteins: 
     ENSP00000295400   ENSP00000407432   ENSP00000387493   ENSP00000404099   ENSP00000414127  
     ENSP00000404131   ENSP00000377787  

    TGFA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TGFA Protein
    R&D Systems Recombinant & Natural Proteins for TGFA (TGF-alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TGFA
    OriGene Protein Over-expression Lysate for TGFA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TGFA
    GenScript Custom Purified and Recombinant Proteins Services for TGFA
    Novus Biologicals TGFA Proteins
    Novus Biologicals TGFA Lysates
    Sino Biological Recombinant Protein for TGFA
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TGFA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TGFA (TGF-alpha)
    Cell Signaling Technology (CST) Antibodies for TGFA  (TGFalpha)
    OriGene Antibodies for TGFA
    OriGene Custom Antibody Services for TGFA
    Novus Biologicals TGFA Antibodies
    Abcam antibodies for TGFA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TGFA
    LSBio Antibodies in human, mouse, rat for TGFA

    TGFA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TGFA
    R&D Systems ELISAs for TGFA (TGF-alpha)         (see all)
    GenScript Custom Assay Services for TGFA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015497 EGF_rcpt_ligand
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P01135

    ProtoNet protein and cluster: P01135

    2 Blocks protein domains:
    IPB001336 Type I EGF signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
    Similarity: Contains 1 EGF-like domain


    TGFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGFA_HUMAN, P01135
    Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act
    synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

         Genatlas biochemistry entry for TGFA:
    transforming growth factor,alpha,17kDa,expressed in macrophages,brain cells,keratinocyte,also expressed at high
    levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in
    mice,epidermal growth factor family,involved in mitogenesis and angiogenenesis,potentially mutated in cleft lip
    with or without cleft palate

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0004708MAP kinase kinase activity IDA11278323
    GO:0005154epidermal growth factor receptor binding IDA11278323
    GO:0005515protein binding IPI15064403
    GO:0008083growth factor activity IDA11278323
         
    TGFA for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tgfa):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  immune system  integument  muscle  reproductive system 
     skeleton  vision/eye 

    TGFA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TGFA: Tgfatm1Ard Tgfatm1Unc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TGFA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TGFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TGFA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TGFA

    miRNA
    Products:
        
    miRTarBase miRNAs that target TGFA:
    hsa-mir-152-3p (MIRT035552), hsa-mir-92a-3p (MIRT049451)

    Block miRNA regulation of human, mouse, rat TGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFA (see all 53):
    hsa-miR-323-3p hsa-miR-2052 hsa-miR-301a hsa-miR-374a hsa-miR-759 hsa-miR-34b hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidTGFA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TGFA
    Predesigned siRNA for gene silencing in human, mouse, rat TGFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TGFA

    Clone
    Products:
         
    OriGene clones in human, mouse for TGFA (see all 11)
    OriGene ORF clones in mouse, rat for TGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFA (NM_003236)
    Sino Biological Human cDNA Clone for TGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TGFA
    Browse ESI BIO Cell Lines and PureStem Progenitors for TGFA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGFA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGFA_HUMAN, P01135: Transforming growth factor alpha: Secreted, extracellular space
    TGFA_HUMAN, P01135: Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA12743035
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane NAS10918572
    GO:0009986cell surface IDA12743035
    GO:0016021integral component of membrane IEA--

    TGFA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TGFA About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TGFA (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for TGFA
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for TGFA
        Development ERBB-family signaling
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Development EGFR signaling pathway

    4 BioSystems Pathways for TGFA
        ErbB signaling pathway
    ErbB receptor signaling network
    Direct p53 effectors
    FOXM1 transcription factor network


    1 PharmGKB Pathway for TGFA
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for TGFA) (see all 7):
        ErbB signaling pathway
    Pathways in cancer
    Renal cell carcinoma
    Pancreatic cancer
    Glioma


    TGFA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFA (see all 9): 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TGFA (P011351, 2, 3 ENSP000002954004) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGI2Q86UL82, 3, ENSP000003461514MINT-1894829 I2D: score=2 STRING: ENSP00000346151
    MAGI3Q5TCQ92, 3, ENSP000003046044MINT-1894801 I2D: score=3 STRING: ENSP00000304604
    NKD2Q969F23, ENSP000002968494I2D: score=3 STRING: ENSP00000296849
    GORASP1Q9BQQ33, ENSP000003138694I2D: score=2 STRING: ENSP00000313869
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA11278323
    GO:0000187activation of MAPK activity IDA11278323
    GO:0001525angiogenesis IEA--
    GO:0007173epidermal growth factor receptor signaling pathway IEA--
    GO:0008283cell proliferation TAS10861448

    TGFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TGFA

    Selected Novoseek inferred chemical compound relationships for TGFA gene (see all 139)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 73.4 11 15355899 (1), 10722725 (1), 11178955 (1), 12600830 (1) (see all 9)
    pd153035 72.5 4 8980296 (1), 16443372 (1), 11178955 (1)
    tyrosine 68.5 153 1572907 (5), 7980404 (4), 9716460 (2), 2302227 (2) (see all 94)
    gefitinib 64.9 34 16230376 (5), 11350918 (4), 16585207 (4), 16568376 (2) (see all 11)
    8-chloro-camp 60.1 5 1850725 (1), 9815703 (1), 8381655 (1), 14691008 (1)
    vegf 59.7 244 18685072 (7), 19628074 (6), 15379270 (5), 10938383 (5) (see all 99)
    estrogen 57.9 151 7720660 (8), 9605408 (4), 11698343 (4), 8360257 (3) (see all 61)
    thymidine 56.9 53 1717146 (3), 8033155 (2), 7714549 (2), 11466216 (2) (see all 35)
    cetuximab 53.5 11 19276250 (3), 16806963 (1), 16675911 (1), 20047592 (1) (see all 5)
    tgf beta1 53 29 14627647 (6), 10598907 (3), 10928772 (3), 16139244 (2) (see all 12)



    TGFA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TGFA gene (2 alternative transcripts): 
    NM_001099691.2  NM_003236.3  

    Unigene Cluster for TGFA:

    Transforming growth factor, alpha
    Hs.170009  [show with all ESTs]
    Unigene Representative Sequence: NM_003236
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295400(uc010fdq.3 uc010fdr.3 uc002sgs.4 uc002sgt.4 uc002sgu.3 uc002sgv.3 uc002sgw.3)
    ENST00000419940 ENST00000445399 ENST00000418333 ENST00000450929 ENST00000444975
    ENST00000394241 ENST00000460808 ENST00000474101
    miRNA
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    Block miRNA regulation of human, mouse, rat TGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TGFA (see all 53):
    hsa-miR-323-3p hsa-miR-2052 hsa-miR-301a hsa-miR-374a hsa-miR-759 hsa-miR-34b hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidTGFA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TGFA
    Predesigned siRNA for gene silencing in human, mouse, rat TGFA
    Clone
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    OriGene clones in human, mouse for TGFA (see all 11)
    OriGene ORF clones in mouse, rat for TGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TGFA (NM_003236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGFA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TGFA
    OriGene qSTAR qPCR primer pairs in human, mouse for TGFA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TGFA
      QuantiTect SYBR Green Assays in human, mouse, rat TGFA
      QuantiFast Probe-based Assays in human, mouse, rat TGFA

    Additional mRNA sequence: 

    AF149096.1 AF149097.1 AF149098.1 AK290151.1 AK309066.1 AK309220.1 AK312899.1 AY548763.1 
    BC005308.1 BT006833.1 K03222.1 M31172.1 X70340.1 

    3 DOTS entries:

    DT.409431  DT.92422695  DT.120952753 

    Selected AceView cDNA sequences (see all 68):

    AW340378 AY548763 AV727156 BC005308 BQ942216 BX093407 BU728692 AL698738 
    AI858901 BI760767 X70340 BU189356 BE925944 AW452101 AW469943 AF149098 
    AI823651 AF149097 AI206396 BV206634 K03222 M31172 BM453873 AA933077 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TGFA (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -     -           -     -                                   -                     
    SP2:                    -     -           -     -                                   -                     
    SP3:                    -     -           -     -                                   -     -     -         
    SP4:                    -     -           -     -                                                         
    SP5:                    -     -           -     -                                   -     -     -         


    ECgene alternative splicing isoforms for TGFA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TGFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TGFA Expression
    About this image


    TGFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
             Zygote Zygote
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
             Zygote Zygote
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Striatum
    TGFA Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.170009

    UniProtKB/Swiss-Prot: TGFA_HUMAN, P01135
    Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TGFA (see all 9): 
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              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TGFA gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tgfa1 , 5 transforming growth factor alpha1, 5 88.47(n)1
    92.45(a)1
      6 (37.62 cM)5
    218021  NM_031199.31  NP_112476.11 
     861952515 
    chicken
    (Gallus gallus)
    Aves TGFA1 transforming growth factor, alpha 74.89(n)
    74.03(a)
      414743  NM_001001614.1  NP_001001614.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004854341 protransforming growth factor alpha-like 70.04(n)
    74.05(a)
      100485434  XM_002935302.2  XP_002935348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tgfa6
    transforming growth factor, alpha
    33(a)
    1 ↔ 1
    6(40923273-40940245) ENSDARG00000053939


    ENSEMBL Gene Tree for TGFA (if available)
    TreeFam Gene Tree for TGFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TGFA gene
    BTC2  
    4 SIMAP similar genes for TGFA using alignment to 8 protein entries:     TGFA_HUMAN (see all proteins):
    EGF    BTC    EPGN    NRG4

    TGFA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TGFA (see all 2376)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477169721,2
    Cuntested170609360(+) AGTTAA/C/GCACAG 2 -- int10--------
    rs1504146531,2
    C--70433917(+) GAGAA-/GGAGAGA 2 -- int10--------
    rs1998003721,2
    --70468319(+) TATAT-/ATATATATA
    TATATATATAC
    ACACA
    2 -- int10--------
    rs2007331431,2
    C--70468321(+) TATAT-/ATATATAT
    ATATATATAC
    ACACA
    2 -- int10--------
    rs724061071,2
    C--70475773(+) GAATA-/AC    
       
    /ACAC
    CACAC
    2 -- int11CSA 2
    rs349552241,2
    C--70484303(+) GAGGA-/CGGAGA 2 -- int10--------
    rs134216421,2
    A--70485495(+) TTGTTG/TGtttg 2 -- int10--------
    rs612928401,2
    C--70498594(+) TTTAT-/GATATTTC 2 -- cds10--------
    rs1143554461,2
    C,F--70539960(+) CAAAGA/TTTTGC 2 -- ds50011Minor allele frequency- T:0.11WA 118
    rs114663071,2
    C,F,H--70539980(-) CCTGTG/AAACTT 2 -- ds500119Minor allele frequency- A:0.04NA EU NS EA WA 2144

    HapMap Linkage Disequilibrium report for TGFA (70674412 - 70781325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TGFA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834255CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TGFA
    DNA2.0 Custom Variant and Variant Library Synthesis for TGFA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190170    OMIM disorders: --

    Selected diseases for TGFA (see all 189):    
    About MalaCards
    tooth agenesis, selective, 1, with or without orofacial cleft    bone marrow necrosis    bronchiolo-alveolar adenocarcinoma    nonpapillary renal cell carcinoma
    embryonal cancer    prostate cancer 1    ovarian cystadenoma    esophagus adenocarcinoma
    juvenile polyposis syndrome    warthin tumor    alstrom syndrome    hypothalamic hamartomas
    leukoplakia    cystadenoma    cleft lip    cholesteatoma
    arteriovenous fistula    acanthosis nigricans    verrucous carcinoma    cleidocranial dysplasia

    3 diseases from the University of Copenhagen DISEASES database for TGFA:
    Cleft lip     Cleft palate     Tooth agenesis

    TGFA for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TGFA gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 70.4 926 11727256 (8), 1746909 (5), 1519669 (5), 7687782 (5) (see all 99)
    menetrier disease 64.4 35 1451986 (5), 8636814 (5), 8522306 (4), 15887112 (3) (see all 9)
    cholesteatoma middle ear 61.7 8 8817015 (2), 8369082 (1), 12725186 (1), 11078065 (1)
    cleft lip 61.3 76 18788876 (3), 9003904 (3), 15449618 (3), 17334078 (3) (see all 36)
    cleft palate 60.4 62 15449618 (3), 8105683 (3), 17334078 (3), 10552925 (2) (see all 28)
    carcinoma squamous cell 59.6 106 9828815 (5), 8843456 (4), 1863074 (3), 9625170 (3) (see all 54)
    breast cancer 58.7 185 8508397 (5), 1912611 (4), 10668644 (4), 8137282 (3) (see all 90)
    colon carcinoma 57.3 62 8014008 (4), 8398905 (4), 11973637 (3), 9935234 (3) (see all 29)
    carcinoma 56.9 189 8523820 (5), 9542514 (4), 8371007 (4), 8625090 (3) (see all 99)
    hyperplasia 56.1 80 10233260 (2), 10708482 (2), 8371007 (2), 12607604 (2) (see all 51)

    Genetic Association Database (GAD): TGFA
    Human Genome Epidemiology (HuGE) Navigator: TGFA (44 documents)
    Tumor Gene Database (TGDB): TGFA

    Export disorders for TGFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TGFA gene, integrated from 10 sources (see all 2064):
    (articles sorted by number of sources associating them with TGFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only. (PubMed id 10552925)1, 2, 3, 9 Machida J....Murray J.C. (Genomics 1999)
    2. TGFA/TAQ I polymorphism in nonsyndromic cleft lip and palate patients from Rio Grande Do Sul, Brazil. (PubMed id 18788876)1, 4, 9 Ehlers Bertoja A....Miriam Robinson W. (Cleft Palate Craniofac. J. 2008)
    3. [Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate]. (PubMed id 17334078)1, 4, 9 Yuan K.F....Zhou X.H. (Hua Xi Kou Qiang Yi Xue Za Zhi 2006)
    4. [The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate]. (PubMed id 15449618)1, 4, 9 Zhang W.G....Liang J. (Zhonghua Zheng Xing Wai Ke Za Zhi 2004)
    5. Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia. (PubMed id 18956930)1, 4, 9 Rahman R.A....Samsudin A.R. (Cleft Palate Craniofac. J. 2008)
    6. Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. (PubMed id 8100397)1, 2, 9 Qian J.F.... May E. (Am. J. Hum. Genet. 1993)
    7. Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. (PubMed id 20047592)1, 4, 9 Han S.W....Kim T.Y. (Cancer Sci. 2010)
    8. MTHFR, TGFB3, and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China. (PubMed id 20082468)1, 4, 9 Zhu J....Li Z. (Am. J. Med. Genet. A 2010)
    9. Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms. (PubMed id 19444471)1, 4, 9 Sull J.W....Beaty T.H. (Hum. Genet. 2009)
    10. [Association between parental transforming growth factor alpha gene TaqI variant, paternal smoking and the cleft lip with or without cleft palate]. (PubMed id 17313741)1, 4, 9 Zhu J.H....Li Z. (Zhonghua Yu Fang Yi Xue Za Zhi 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7039 HGNC: 11765 AceView: TGFA Ensembl:ENSG00000163235 euGenes: HUgn7039
    ECgene: TGFA Kegg: 7039 H-InvDB: TGFA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TGFA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TGFA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TGFA gene:
    Search GeneIP for patents involving TGFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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