TGDS Gene
protein-coding GIFtS: 50
GCID: GC13M095226
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TDP-glucose 4,6-dehydratase
| |
Aliases
for TGDS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TDP-Glucose 4,6-Dehydratase1 2 | | Growth-Inhibiting Protein 212 | | SDR2E11 2 | | Short Chain Dehydrogenase/Reductase Family 2E, Member 12 | | TDPGD1 2 | | EC 4.2.1.463 | | DTDP-D-Glucose 4,6-Dehydratase2 | | P5 |
Export aliases for TGDS gene to outside databasesPrevious GC identifers: GC13M094062 GC13M092924 GC13M094024 GC13M075823 |
Summaries
for TGDS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TGDS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TGDS gene promoter:
SRF GR SRF (504 AA) PPAR-gamma1 GCNF-1 PPAR-gamma2 GR-alpha GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TGDS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGDS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q32.1 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q32.1TGDS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M095226: view genomic region
(about GC identifiers)
Start:
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95,226,308 bp from pter |
End:
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95,248,511 bp from pter |
Size:
|
22,204 bases |
Orientation:
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minus strand |
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Proteins
for TGDS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TGDS_HUMAN, O95455 (See
protein sequence)Recommended Name: dTDP-D-glucose 4,6-dehydratase Size: 350 amino acids; 40214 Da
Cofactor: NAD (By similarity)
Secondary accessions: Q5T3Z2 Q9H1T9Explore the universe of human proteins at neXtProt for TGDS: NX_O95455
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95455
TGDS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055120.1
ENSEMBL proteins: ENSP00000261296
Human Recombinant Protein Products:
TGDS Antibody Products:
Assay Products for TGDS: |
Protein
Domains /
Families
for TGDS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TGDS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95455ProtoNet protein and cluster: O95455 1 Blocks protein family: IPB001509 NAD-dependent epimerase/dehydratase
UniProtKB/Swiss-Prot: TGDS_HUMAN, O95455Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily |
Function
for TGDS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TGDS_HUMAN, O95455Catalytic activity: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)OEnzyme Number (IUBMB): EC 4.2.1.461
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TGDS (NM_000954) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGDS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGDS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGDS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0008460 | dTDP-glucose 4,6-dehydratase activity |
IEA | -- | | GO:0050662 | coenzyme binding |
IEA | -- |
TGDS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TGDS:
Animal Models:
1 MGI phenotypic allele  for Tgds (no phenotypes)
TGDS for phenotypes About GeneDecksing
|
Pathways & Interactions
for TGDS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for TGDS):
TGDS for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TGDS
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for TGDS (O954553 ENSP000002612964) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009225 | nucleotide-sugar metabolic process |
IEA | -- |
TGDS for ontologies About GeneDecksing
|
Drugs & Compounds
for TGDS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TGDS
6 HMDB Compounds for TGDS About this table
Search CenterWatch for drugs/clinical trials and news about TGDS
|
Transcripts
for TGDS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TGDS gene: NM_014305.2 Unigene Cluster for TGDS: TDP-glucose 4,6-dehydratase Hs.12393 [show with all ESTs]Unigene Representative Sequence: NM_0143053 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261296(uc001vlw.3) ENST00000498294 ENST00000470480
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TGDS (NM_000954) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TGDS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGDS |
Additional cDNA sequence: AF048686.1 AF339778.1 AJ006068.1 AK303439.1 AK313251.1 AY544125.1 BC005284.1 BC033675.1 7 DOTS entries: DT.442855 DT.100712436 DT.120762296 DT.303955 DT.92427708 DT.99976687 DT.40283582 24/145 AceView cDNA sequences (see all 145): AI347251 AA668890 BC033675 BU688902 AA831973 AA307446 BE018314 BI765488 AV685357 AA976208 AI469242 BE301796 AL712883 AI972505 AA296374 AI539664 BP374487 AA776218 AI683375 BC005284 BX109198 CR606771 W95434 BI914642
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TGDS About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TGDS
|
Expression
for TGDS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TGDS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACTGTTT
About this image
See TGDS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TGDS
SOURCE GeneReport for Unigene cluster: Hs.12393
SABiosciences Custom PCR Arrays for TGDS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGDS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TGDS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGDS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGDS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGDS |
Orthologs
for TGDS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TGDS gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for TGDS (if available)
TreeFam Gene Tree for TGDS (if available) |
Paralogs
for TGDS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TGDS gene
- UXS12 GALE2
TGDS for paralogs About GeneDecksing
|
Genomic Variants
for TGDS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TGDS (95226308 - 95248511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TGDS
2 CNVs: 47869 58646 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGDS |
|
Disorders
/ Diseases
for TGDS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TGDS for disorders About GeneDecksing
OMIM gene information: 176803
OMIM disorders: --
2  diseases for TGDS: About MalaCardstuberculosis mycobacterium tuberculosis
Export disorders for TGDS gene to outside databases
|
Publications
for TGDS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TGDS gene integrated from 9 sources:
(articles sorted by number of sources associating them with TGDS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TGDS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TGDS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TGDS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TGDS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TGDS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TGDS gene:
Search GeneIP for patents involving TGDS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TGDS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TGDS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TGDS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TGDS | | | OriGene Protein Over-expression Lysate for TGDS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TGDS | | OriGene 3'-UTR Clone for TGDS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TGDS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TGDS | | OriGene Custom Protein Services for TGDS | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TGDS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TGDS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TGDS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TGDS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TGDS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TGDS |
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 |  |  |  | |
| | | | Search Tocris compounds for TGDS |
| |  |  |  |  | | | | |
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 | | | TGDS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TGDS |
|  |  |  | | | | Search ThermoFisher Antibodies for TGDS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TGDS |
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