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TG Gene

protein-coding   GIFtS: 59
GCID: GC08P133879

Thyroglobulin

  See TG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
thyroglobulin1 2
AITD32 5
TGN2
Tg3
TDH35

External Ids:    HGNC: 117641   Entrez Gene: 70382   Ensembl: ENSG000000428327   OMIM: 1884505   UniProtKB: P012663   

Export aliases for TG gene to outside databases

Previous GC identifers: GC08P132608 GC08P133966 GC08P133550 GC08P133835 GC08P133948 GC08P129197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TG Gene:
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a
substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of
thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination,
and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid
dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism.
Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as
Graves disease and Hashimoto thryoiditis. (provided by RefSeq, Nov 2009)

GeneCards Summary for TG Gene:
TG (thyroglobulin) is a protein-coding gene. Diseases associated with TG include goiter, and endemic goiter. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Gene Wiki entry for TG (Thyroglobulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TG gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   COUP-TF   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TG promoter sequence
   Search Chromatin IP Primers for TG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

TG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TG gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P133879:  view genomic region     (about GC identifiers)

Start:
133,879,203 bp from pter      End:
134,147,147 bp from pter
Size:
267,945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: THYG_HUMAN, P01266 (See protein sequence)
Recommended Name: Thyroglobulin precursor  
Size: 2768 amino acids; 304790 Da
Subunit: Homodimer
Secondary accessions: O15274 O43899 Q15593 Q15948 Q9NYR1 Q9NYR2 Q9UMZ0 Q9UNY3
Alternative splicing: 2 isoforms:  P01266-1   P01266-2   

Explore the universe of human proteins at neXtProt for TG: NX_P01266

Explore proteomics data for TG at MOPED

Post-translational modifications: 

  • Sulfated tyrosines are desulfated during iodination1
  • Glycosylation2 at Asn76, Asn198, Asn484, Asn529, Asn748, Asn816, Asn947, Asn1220, Asn1348, Asn1349,
                                 Asn1365, Asn1716, Asn1774, Asn2013, Asn2250, Asn2295, Asn2582, Ser2749
  • Modification sites at PhosphoSitePlus

  • See TG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003226.4  
    ENSEMBL proteins: 
     ENSP00000427871   ENSP00000220616   ENSP00000428628   ENSP00000429605   ENSP00000430523  
     ENSP00000429164   ENSP00000430430   ENSP00000430087   ENSP00000429761   ENSP00000430161  
     ENSP00000367100   ENSP00000441693  

    TG Human Recombinant Protein Products:

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    OriGene Purified Protein for TG
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    Novus Biologicals TG Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TG
    Cloud-Clone Corp. Proteins for TG

     
    Search eBioscience for Proteins for TG 

     
    antibodies-online proteins for TG (24 products) 

     
    Search antibodies-online for peptides for TG

    TG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for TG (227 products) 

    TG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TG
    Cloud-Clone Corp. CLIAs for TG
    Search eBioscience for ELISAs for TG 
    antibodies-online kits for TG (48 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
     IPR000716 Thyroglobulin_1
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB
     IPR016324 Thyroglobulin

    Graphical View of Domain Structure for InterPro Entry P01266

    ProtoNet protein and cluster: P01266

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Similarity: Belongs to the type-B carboxylesterase/lipase family
    Similarity: Contains 11 thyroglobulin type-1 domains


    Find genes that share domains with TG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THYG_HUMAN, P01266
    Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

         Genatlas biochemistry entry for TG:
    thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872NOT receptor activity IRD--
    GO:0005179hormone activity IEA--
    GO:0042043NOT neurexin family protein binding IRD--
         
    Find genes that share ontologies with TG           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tg):
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with TG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TG

    miRNA
    Products:
        
    miRTarBase miRNAs that target TG:
    hsa-let-7f-5p (MIRT032091)

    Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TG

    Clone
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    OriGene clones in human, mouse for TG (see all 5)
    OriGene ORF clones in mouse, rat for TG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TG
    Browse ESI BIO Cell Lines and PureStem Progenitors for TG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11466 VA6-13133) for TG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THYG_HUMAN, P01266: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum3
    plasma membrane3
    cytoskeleton2
    golgi apparatus2
    lysosome2
    mitochondrion2
    nucleus2
    vacuole2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IBA--
    GO:0005887NOT integral component of plasma membrane IRD--
    GO:0009986NOT cell surface IRD--
    GO:0045202NOT synapse IRD--

    Find genes that share ontologies with TG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TG About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Autoimmune thyroid disease0.61
    2Insulin secretion
    Thyroid hormone synthesis0.36
    3Thyroxine (Thyroid Hormone) Production
    Thyroxine (Thyroid Hormone) Production


    Find genes that share SuperPaths with TG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TG
        Thyroxine (Thyroid Hormone) Production


    2 Kegg Pathways  (Kegg details for TG):
        Thyroid hormone synthesis
    Autoimmune thyroid disease

        Pathway & Disease-focused RT2 Profiler PCR Array including TG: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TG (P012663 ENSP000002206164) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110213, ENSP000003241734I2D: score=4 STRING: ENSP00000324173
    ASGR1P073063, ENSP000002692994I2D: score=1 STRING: ENSP00000269299
    CTSDP073393, ENSP000002366714I2D: score=1 STRING: ENSP00000236671
    APCSP027433, ENSP000002550404I2D: score=1 STRING: ENSP00000255040
    CANXP278243, ENSP000002474614I2D: score=1 STRING: ENSP00000247461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation IBA--
    GO:0007165signal transduction NAS3016640
    GO:0007416NOT synapse assembly IRD--
    GO:0015705iodide transport IEA--
    GO:0030878thyroid gland development IEP15494458

    Find genes that share ontologies with TG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TG (THYG)

    Selected Novoseek inferred chemical compound relationships for TG gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iodine 91.3 525 1954313 (7), 9292948 (6), 12713257 (4), 19160311 (4) (see all 99)
    thyroxine 90.9 582 1466156 (7), 10229914 (6), 11694378 (4), 8890722 (4) (see all 99)
    iodide 83.8 155 10537174 (6), 16648292 (4), 19951699 (3), 20364596 (3) (see all 73)
    triiodothyronine 83.3 331 11288978 (4), 11694378 (4), 10822292 (4), 16477365 (3) (see all 99)
    sodium iodide 78.5 31 19050049 (2), 10090312 (1), 17199440 (1), 18430446 (1) (see all 21)
    diiodotyrosine 77.4 15 8900403 (3), 1954313 (1), 8651700 (1), 9717982 (1) (see all 7)
    iodotyrosine 73.2 15 15289438 (2), 1727828 (1), 9737985 (1), 1281126 (1) (see all 9)
    methimazole 69.9 8 14657389 (1), 1794603 (1), 1688155 (1), 8075781 (1) (see all 5)
    thyronine 66.5 6 9434803 (1), 9717982 (1), 9344702 (1), 9419438 (1)
    18f fluorodeoxyglucose 60.9 40 12186505 (4), 19910903 (2), 10452315 (2), 12656659 (2) (see all 19)



    Find genes that share compounds with TG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TG gene: 
    NM_003235.4  

    Unigene Cluster for TG:

    Thyroglobulin
    Hs.654591  [show with all ESTs]
    Unigene Representative Sequence: NM_003235
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000523901 ENST00000220616(uc003ytw.3 uc010mdw.3) ENST00000520769
    ENST00000523756(uc011ljb.2) ENST00000518097 ENST00000518505 ENST00000519178
    ENST00000518058 ENST00000519543(uc011ljc.2) ENST00000520197 ENST00000520089
    ENST00000519294 ENST00000524151 ENST00000522523 ENST00000522797 ENST00000518108
    ENST00000522996 ENST00000522809
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat TG
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TG
      QuantiTect SYBR Green Assays in human, mouse, rat TG
      QuantiFast Probe-based Assays in human, mouse, rat TG
    Flow Cytometry
    Products:
       

     
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    Additional mRNA sequence: 

    AB209159.1 AK299197.1 AK303666.1 AK303667.1 BC127887.1 BC140933.1 S40807.1 S80793.1 
    X02154.1 X05615.1 

    Selected DOTS entries (see all 80):

    DT.95202433  DT.95177266  DT.95219259  DT.91713338  DT.100826698  DT.100826700  DT.452683  DT.92472293 
    DT.120642240  DT.95333374  DT.120642266  DT.100826697  DT.100826709  DT.100826704  DT.120642467  DT.100826710 
    DT.120642305  DT.120642340  DT.91698313  DT.95333484  DT.100829949  DT.92472287  DT.95333469  DT.95246308 

    Selected AceView cDNA sequences (see all 1041):

    AU141761 AA384674 AU141693 AU142018 AU141921 AU141623 AU141456 AU141850 
    AU141264 AU141642 AA384456 BE168159 AU141713 AU141584 AA385241 AU141981 
    AU141691 AU141975 AA385060 AU142003 AU141892 AU141459 AU141307 AU141980 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TG Expression
    About this image


    TG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thyroid (Endocrine System)
             Thyroid Progenitors
     
     Gut Tube (Gastrointestinal Tract)
             Anterior foregut progenitor cells
     
     Lung (Respiratory System)
             Immature proximal lung cells
     
     Larynx (Respiratory System)
    TG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654591

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Tissue specificity: Thyroid gland specific

        Pathway & Disease-focused RT2 Profiler PCR Array including TG: 
              Insulin Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tg1 , 5 thyroglobulin1, 5 78.6(n)1
    74.35(a)1
      15 (29.30 cM)5
    218191  NM_009375.21  NP_033401.21 
     666707535 
    chicken
    (Gallus gallus)
    Aves TG1 thyroglobulin 61.3(n)
    55.62(a)
      100857838  XM_003640868.2  XP_003640916.2 
    lizard
    (Anolis carolinensis)
    Reptilia TG6
    thyroglobulin
    53(a)
    1 ↔ 1
    4(662513-807612)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tg1 thyroglobulin 55.55(n)
    48.51(a)
      100492021  XM_002939515.2  XP_002939561.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tg1 thyroglobulin 52.54(n)
    44.44(a)
      567631  XM_689200.5  XP_694292.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Est86
    alpha-Esterase-8
    18(a)
    1 → many
    3R(3335065-3341391)
    worm
    (Caenorhabditis elegans)
    Secernentea Y75B8A.36
    Protein Y75B8A.3 (Y75B8A.3) mRNA, complete cds
    12(a)
    1 ↔ 1
    III(12101745-12106535) WBGene00013540


    ENSEMBL Gene Tree for TG (if available)
    TreeFam Gene Tree for TG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TG gene
    9 SIMAP similar genes for TG using alignment to 13 protein entries:     THYG_HUMAN (see all proteins):
    NLGN2    CES2    CES3    CES5A    NLGN3    DKFZp686F02202
    ACHE    BCHE    CES1P1

    Find genes that share paralogs with TG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TG (see all 6587)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20767381,2,,4
    C,HThyroid dyshormonogenesis 3 (TDH3)4 --134192929(+) TGATAT/CGTAGC 2 /R /C mis1 ese37Minor allele frequency- C:0.00EA NS NA 644
    rs20767391,2,,4
    CThyroid dyshormonogenesis 3 (TDH3)4 pathogenic1134257890(+) TTGAAT/AGTGAA 2 /S /C mis11Minor allele frequency- A:0.00EA 220
    VAR_0630374
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630372 R Q mis40--------
    VAR_0630354
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630352 C Y mis40--------
    VAR_0630364
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630362 A D mis40--------
    VAR_0630344
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630342 C Y mis40--------
    VAR_0630384
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630382 G R mis40--------
    rs1219126481,2
    C,Fpathogenic1134168695(+) GATTCC/TGATGT 2 R * stg12Minor allele frequency- T:0.00NA EU 5871
    rs1219126461,2
    Cpathogenic1134209483(+) AGTATC/TGAGCC 2 R * stg10--------
    rs20695661,2,,4
    Cpathogenic1134304022(+) GAGGCG/ACTTCC 2 /H /R mis1 ese33Minor allele frequency- A:0.00EA NA 20

    HapMap Linkage Disequilibrium report for TG (133879203 - 134129203 bp, first 250kb of TG)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TG (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2622999CNV Insertion19546169
    nsv509279CNV Insertion20534489
    esv1530894CNV Insertion17803354
    nsv6403CNV Insertion18451855
    nsv6402CNV Insertion18451855
    nsv891456CNV Loss21882294
    nsv525105CNV Loss19592680
    esv33367CNV Loss17666407
    nsv465818CNV Loss19166990
    esv33561CNV Loss17666407

    Human Gene Mutation Database (HGMD): TG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TG
    DNA2.0 Custom Variant and Variant Library Synthesis for TG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188450   
    OMIM disorders: 274700  608175  
    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
  • Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing
    large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid
    dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a
    relatively high serum free triiodothyronine (T3) concentration with disproportionately low free
    tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue
    hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and
    intellectual defects in some cases. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related
    diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive
    T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2
    differentiation and activate B cells to produce antibodies against the TSH receptor, which stimulate the thyroid
    and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the
    thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for TG (see all 36):    
    About MalaCards
    goiter    endemic goiter    thyroid dyshormonogenesis 3    autoimmune thyroid disease 3
    laryngocele    malignant struma ovarii    struma ovarii    suppurative thyroiditis
    nontoxic goiter    hashimoto's encephalitis    hypothyroidism    toxic diffuse goiter
    subacute thyroiditis    non-herpetic acute limbic encephalitis    myxedema    graves' disease
    thyroiditis    thyrotoxicosis    multinodular goiter    limbic encephalitis

    12 diseases from the University of Copenhagen DISEASES database for TG:
    Thyroid cancer     Autoimmune thyroiditis     Goiter     Hypothyroidism
    Hyperthyroidism     Thyrotoxicosis     Subacute thyroiditis     Carcinoma
    Thyroid adenoma     Adenoma     Teratoma     Suppurative thyroiditis

    Find genes that share disorders with TG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 95.4 414 17892441 (5), 18630997 (4), 19160311 (4), 11325833 (3) (see all 99)
    thyroid cancer 95 436 17302864 (4), 14588101 (3), 16479246 (3), 18613899 (3) (see all 99)
    autoimmune thyroid disease 92.8 143 10570317 (3), 15096179 (3), 2256432 (2), 14973426 (2) (see all 78)
    hashimotos thyroiditis 90.5 101 2242608 (3), 2226281 (2), 10670755 (2), 7962336 (2) (see all 69)
    graves disease 89.4 145 16646680 (3), 1724781 (2), 10984889 (2), 11092696 (2) (see all 85)
    thyroid diseases 89.1 126 18243140 (4), 10984889 (3), 11228272 (3), 12022704 (3) (see all 72)
    goiter 88.5 123 2129364 (4), 1851064 (4), 7549998 (3), 9588493 (2) (see all 79)
    goiter congenital 88.5 55 10199792 (3), 14764776 (2), 8325944 (2), 15769978 (2) (see all 33)
    hypothyroidism 88.4 117 9790265 (3), 15014299 (2), 8966023 (2), 17978827 (2) (see all 84)
    thyroid papillary carcinoma 87.6 64 15579752 (2), 1305063 (2), 16033735 (2), 16201895 (2) (see all 37)

    Genatlas disease: TG
    goiter associated to hypothyroidism and variant type of adenomatous goiter

    Genetic Association Database (GAD): TG
    Human Genome Epidemiology (HuGE) Navigator: TG (885 documents)

    Export disorders for TG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TG gene, integrated from 10 sources (see all 1766):
    (articles sorted by number of sources associating them with TG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PubMed id 19509106)1, 2, 9 Pardo V.... Medeiros-Neto G. (J. Clin. Endocrinol. Metab. 2009)
    2. Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PubMed id 10199792)1, 2, 9 Hishinuma A.... Ieiri T. (J. Clin. Endocrinol. Metab. 1999)
    3. Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent- exposed regions of the primary structure. (PubMed id 8269951)1, 2, 9 Gentile F. and Salvatore G. (Eur. J. Biochem. 1993)
    4. A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PubMed id 16477365)1, 2, 9 Kitanaka S....Igarashi T. (J. Hum. Genet. 2006)
    5. Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. (PubMed id 8797845)1, 2, 9 Molina F.... Granier C. (Eur. J. Biochem. 1996)
    6. Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. (PubMed id 7793989)1, 2, 9 Xiao S.... Rawitch A.B. (Arch. Biochem. Biophys. 1995)
    7. Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes. (PubMed id 20215770)1, 4, 9 Kotnik P....Battelino T. (Horm Res Paediatr 2010)
    8. Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. (PubMed id 19034705)1, 4, 9 Maierhaba M....Dong B.N. (Endocrine 2008)
    9. Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. (PubMed id 18385936)1, 4, 9 Hsiao J.Y....Ke D.S. (Clin. Exp. Med. 2008)
    10. Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. (PubMed id 18755875)1, 4, 9 Hsiao J.Y....Ke D.S. (Eur. J. Endocrinol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7038 HGNC: 11764 AceView: TG Ensembl:ENSG00000042832 euGenes: HUgn7038
    ECgene: TG Kegg: 7038 H-InvDB: TG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TG Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Thyroglobulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TG gene:
    Search GeneIP for patents involving TG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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