Aliases for TG Gene
External Ids for TG Gene
- HGNC: 11764
- Entrez Gene: 7038
- Ensembl: ENSG00000042832
- OMIM: 188450
- UniProtKB: P01266
Previous GeneCards Identifiers for TG Gene
- GC08P132608
- GC08P133966
- GC08P133550
- GC08P133835
- GC08P133948
- GC08P129197
- GC08P133879
Summaries for TG Gene
-
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
GeneCards Summary for TG Gene
TG (Thyroglobulin) is a Protein Coding gene. Diseases associated with TG include Thyroid Dyshormonogenesis 3 and Familial Thyroid Dyshormonogenesis. Among its related pathways are Aldosterone synthesis and secretion and Allograft rejection. Gene Ontology (GO) annotations related to this gene include hormone activity and carboxylic ester hydrolase activity.
UniProtKB/Swiss-Prot for TG Gene
-
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Additional gene information for TG Gene
- Monarch Initiative
- Search for TG at DataMed
- Search for TG at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TG Gene
Genomics for TG Gene
GeneHancer (GH) Regulatory Elements for TG Gene
- Top Transcription factor binding sites by QIAGEN in the TG gene promoter:
Regulatory Element Products
Genomic Locations for TG Gene
- chr8:132,866,935-133,134,903
- (GRCh38/hg38)
- Size:
- 267,969 bases
- Orientation:
- Plus strand
- chr8:133,879,203-134,147,147
- (GRCh37/hg19)
Genomic View for TG Gene
- Cytogenetic band:
-
- 8q24.22 by Ensembl
- 8q24.22 by Entrez Gene
- 8q24.22 by HGNC


RefSeq DNA sequence for TG Gene
Proteins for TG Gene
-
Protein details for TG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01266-THYG_HUMAN
- Recommended name:
- Thyroglobulin
- Protein Accession:
- P01266
- O15274
- O43899
- Q15593
- Q15948
- Q9NYR1
- Q9NYR2
- Q9UMZ0
- Q9UNY3
Protein attributes for TG Gene
- Size:
- 2768 amino acids
- Molecular mass:
- 304790 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for TG Gene
Post-translational modifications for TG Gene
- Sulfated tyrosines are desulfated during iodination.
- Glycosylation at posLast=7676, isoforms=2198, isoforms=2484, isoforms=2529, posLast=748748, isoforms=2816, posLast=947947, posLast=12201220, posLast=13481348, posLast=13491349, posLast=13651365, isoforms=21716, isoforms=21774, isoforms=22013, posLast=22502250, isoforms=22295, posLast=25822582, and isoforms=22749
Other Protein References for TG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TG (Thyroglobulin)
-
Custom Antibody ServicesOriGene Antibodies for TG
- CF804834
- TA804834
- CF804642
- TA804642
- CF804620
- TA804620
- CF804410
- TA804410
- CF804409
- TA804409
- TA804362
- CF804361
- TA804361
- CF804297
- TA804297
- CF804258
- TA804258
- CF804257
- TA804257
- CF804255
- TA804255
- CF804254
- TA804254
- CF804215
- TA804215
- CF804214
- TA804214
- CF804213
- TA804213
- CF804212
- TA804212
- CF804211
- TA804211
- CF804209
- TA804209
- CF804167
- TA804167
- CF804166
- TA804166
- CF804165
- TA804165
- CF803993
- TA803993
- CF803992
- TA803992
- CF803991
- TA803991
- CF801456
- TA801456
- TA354119
- TA351796
- TA327747
- TA327746
- TA319577
- DP059-05
- DP059
- DM223-05
- DM223
- BM733
- BM160P
- AP08121PU-S
- AP08121PU-N
- AP02240PU-S
- AP02240PU-N
- AP02239SU-S
- AP02239SU-N
- AM50315PU-T
- AM50315PU-S
- AM50315PU-N
- AM50173PU-T
- AM50173PU-S
- AM50173PU-N
- AM33262PU-T
- AM33262PU-S
- AM33262PU-N
- AM33242PU-T
- AM33242PU-S
- AM33242PU-N
- AM32841PU-T
- AM32841PU-S
- AM32841PU-N
- AM32241SU-N
- AM32225SU-N
- AM31744PU-N
- AM20511PU-N
- AM20510PU-N
- AM20509PU-N
- AM10143PU-T
- AM10143PU-S
- AM10143PU-N
- AM10040PU-S
- AM10040PU-N
- AM10040FC-S
- AM10040FC-N
- AM02241PU-S
- AM02241PU-N
- AM02238PU-S
- AM01234PU-N
- Novus Biologicals Antibodies for TG
-
Abcam antibodies for TG
-
Cloud-Clone Corp. Antibodies for TG
- Invitrogen Antibodies for TG
- antibodies-online: Search results for 533 available Thyroglobulin Antibodies ranked by validation data
- Compare Top Thyroglobulin Antibodies
-
Recommended
- 186 WB Antibodies (anti-human)
- 72 IHC (p) Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 129 WB Antibodies (anti-mouse)
- 17 IHC Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 123 WB Antibodies (anti-rat)
- 16 IHC Antibodies (anti-rat)
- 12 FACS Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- 186 WB Antibodies (anti-human)
- 72 IHC (p) Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 129 WB Antibodies (anti-mouse)
- 17 IHC Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 123 WB Antibodies (anti-rat)
- 16 IHC Antibodies (anti-rat)
- 12 FACS Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- GeneTex TG antibody for TG
-
Santa Cruz Biotechnology (SCBT) Antibodies for TG
Protein Products
-
OriGene Purified Proteins for TG
- Search Origene for MassSpec and Protein Over-expression Lysates for TG
- Origene Custom Protein Services for TG
- Novus Biologicals proteins for TG
- ProSpec Recombinant Proteins for TG
-
Cloud-Clone Corp. Proteins for TG
- GeneTex Proteins for TG
-
Abcam proteins for TG
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TG
- R&D Systems ELISAs and other biochemical assays for TG (Thyroglobulin)
- antibodies-online: Search results for 67 available Thyroglobulin Elisa Kits ranked by validation data
- Compare Top Thyroglobulin Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 3 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 2 Hormone ELISA Kits
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 11 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Chicken ELISA Kit
- 3 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 2 Hormone ELISA Kits
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 11 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
No data available for DME Specific Peptides for TG Gene
Domains & Families for TG Gene
Gene Families for TG Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TG Gene
Suggested Antigen Peptide Sequences for TG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01266- Family:
-
- Belongs to the type-B carboxylesterase/lipase family.
Function for TG Gene
Molecular function for TG Gene
- GENATLAS Biochemistry:
- thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones
- UniProtKB/Swiss-Prot Function:
- Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Phenotypes From GWAS Catalog for TG Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
Phenotypes for TG Gene
- MGI mutant phenotypes for TG:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TG:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TG
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TG gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TG gene
- Search ViGene Biosciences for TG
CRISPR Products
-
OriGene CRISPR knockouts for TG
- genomics-online: gRNA clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- Applied Biological Materials CRISPR for TG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TG
- GenScript: Design CRISPR guide RNA sequences for TG
miRNA for TG Gene
- miRTarBase miRNAs that target TG
-
- hsa-let-7f-5p (MIRT032091)
- hsa-mir-550b-2-5p (MIRT452336)
- hsa-mir-7855-5p (MIRT452337)
- hsa-mir-937-5p (MIRT452338)
- hsa-mir-4710 (MIRT452339)
- hsa-mir-4792 (MIRT452340)
- hsa-mir-650 (MIRT452341)
- hsa-mir-3612 (MIRT452342)
- hsa-mir-2467-3p (MIRT452343)
- hsa-mir-5702 (MIRT452344)
- hsa-mir-1827 (MIRT452345)
- hsa-mir-1247-3p (MIRT452346)
- hsa-mir-4257 (MIRT452347)
- hsa-mir-6511a-5p (MIRT452348)
- hsa-mir-1910-3p (MIRT452349)
- hsa-mir-758-3p (MIRT613470)
- hsa-mir-4652-3p (MIRT613471)
- hsa-mir-4743-3p (MIRT613472)
- hsa-mir-3611 (MIRT613473)
- hsa-mir-383-3p (MIRT613474)
- hsa-mir-6844 (MIRT628573)
- hsa-mir-7161-3p (MIRT652748)
- hsa-mir-3156-5p (MIRT652749)
- hsa-mir-185-5p (MIRT734239)
miRNA Products
- Search ViGene Biosciences for TG
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TG
- Browse OriGene Inhibitory RNA Products For TG
- genomics-online: shRNA clones - Search results for 78 available TGAB gene related products
- Overview of 78 available TGAB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TG gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TG
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- orf clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- Applied Biological Materials Clones for TG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TG
-
ViGene Biosciences adenoviral particle packaged cDNA for TG gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TG gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TG gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TG Gene
Localization for TG Gene
Subcellular locations from UniProtKB/Swiss-Prot for TG Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | NAS | 14718574 |
GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TG Gene
Pathways & Interactions for TG Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Allograft rejection | ||
2 | Aldosterone synthesis and secretion | ||
3 | Thyroxine (Thyroid Hormone) Production |
Pathways by source for TG Gene
1 BioSystems pathway for TG Gene
2 KEGG pathways for TG Gene
Interacting Proteins for TG Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | NAS | 3016640 |
GO:0010469 | regulation of receptor activity | IEA | -- |
GO:0015705 | iodide transport | IEA | -- |
GO:0030878 | thyroid gland development | IEP | 15494458 |
GO:0031641 | regulation of myelination | IEA | -- |
No data available for SIGNOR curated interactions for TG Gene
Drugs & Compounds for TG Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for TG Gene
mRNA/cDNA for TG Gene
- (13) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1041) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TG
- genomics-online: gRNA clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- Applied Biological Materials CRISPR for TG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TG
- GenScript: Design CRISPR guide RNA sequences for TG
miRNA Products
- Search ViGene Biosciences for TG
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TG
- Browse OriGene Inhibitory RNA Products For TG
- genomics-online: shRNA clones - Search results for 78 available TGAB gene related products
- Overview of 78 available TGAB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TG gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TG
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- orf clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- Applied Biological Materials Clones for TG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for TG Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TG Gene
NURSA nuclear receptor signaling pathways regulating expression of TG Gene:
TGSOURCE GeneReport for Unigene cluster for TG Gene:
Hs.654591mRNA Expression by UniProt/SwissProt for TG Gene:
P01266-THYG_HUMANEvidence on tissue expression from TISSUES for TG Gene
- Thyroid gland(5)
- Heart(3.7)
- Kidney(3.3)
- Lymph node(3.2)
- Intestine(3)
- Adrenal gland(2.6)
- Blood(2.6)
- Lung(2.5)
- Nervous system(2.3)
- Liver(2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TG Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
- brain
- ear
- eye
- face
- head
- hypothalamus
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- parathyroid
- pharynx
- pituitary gland
- skull
- thyroid
- tongue
- breast
- heart
- lung
- abdominal wall
- intestine
- large intestine
- liver
- small intestine
- ovary
- rectum
- urinary bladder
- uterus
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for TG
- genomics-online: primer clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
No data available for Protein tissue co-expression partners for TG Gene
Orthologs for TG Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TG 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TG 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TG 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tg 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tg 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TG 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TG 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TG 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TG 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tg 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tg 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | alpha-Est8 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | Y75B8A.3 34 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TG Gene
(9) SIMAP similar genes for TG Gene using alignment to 13 proteins:
No data available for Paralogs for TG Gene
Variants for TG Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10091530 | likely-benign, Thyroid dyshormonogenesis | 133,116,701(+) | A/G/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
rs111363334 | uncertain-significance, Thyroid dyshormonogenesis | 132,893,908(+) | A/C/G | coding_sequence_variant, missense_variant | |
rs112003182 | uncertain-significance, Thyroid dyshormonogenesis | 132,933,606(+) | C/A/T | coding_sequence_variant, missense_variant | |
rs112300885 | uncertain-significance, Thyroid dyshormonogenesis | 132,897,776(+) | C/T | coding_sequence_variant, synonymous_variant | |
rs1133076 | benign, not specified, Thyroid dyshormonogenesis | 133,113,438(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2116e212 | CNV | loss | 25503493 |
esv1530894 | CNV | insertion | 17803354 |
esv2622999 | CNV | insertion | 19546169 |
esv32666 | CNV | gain | 17666407 |
esv32776 | CNV | gain | 17666407 |
esv32991 | CNV | loss | 17666407 |
esv33367 | CNV | loss | 17666407 |
esv33548 | CNV | gain | 17666407 |
esv33561 | CNV | loss | 17666407 |
esv3573001 | CNV | loss | 25503493 |
esv3573002 | CNV | loss | 25503493 |
esv3618883 | CNV | loss | 21293372 |
esv3618884 | CNV | loss | 21293372 |
esv6449 | OTHER | inversion | 19470904 |
nsv465818 | CNV | loss | 19166990 |
nsv473380 | CNV | novel sequence insertion | 20440878 |
nsv482993 | CNV | loss | 15286789 |
nsv509279 | CNV | insertion | 20534489 |
nsv525105 | CNV | loss | 19592680 |
nsv526697 | CNV | loss | 19592680 |
nsv612328 | CNV | loss | 21841781 |
nsv6402 | CNV | insertion | 18451855 |
nsv6403 | CNV | insertion | 18451855 |
nsv831463 | CNV | gain | 17160897 |
nsv949988 | CNV | duplication | 24416366 |
nsv981981 | CNV | duplication | 23825009 |
Additional Variant Information for TG Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TG Gene
Disorders for TG Gene

(92) MalaCards diseases for TG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
thyroid dyshormonogenesis 3 |
|
|
familial thyroid dyshormonogenesis |
|
|
autoimmune thyroid disease 3 |
|
|
hypothyroidism |
|
|
thyroiditis |
|
UniProtKB/Swiss-Prot
THYG_HUMAN- Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism. {ECO:0000269 PubMed:14657345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. {ECO:0000269 PubMed:10199792, ECO:0000269 PubMed:16477365, ECO:0000269 PubMed:17244789, ECO:0000269 PubMed:17532758, ECO:0000269 PubMed:19509106, ECO:0000269 PubMed:27305979}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for TG Gene
Additional Disease Information for TG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for TG Gene
- The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PMID: 19509106) Pardo V … Medeiros-Neto G (The Journal of clinical endocrinology and metabolism 2009) 3 4 22 58
- Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene. (PMID: 17532758) Caputo M … Targovnik HM (Clinical endocrinology 2007) 3 4 22 58
- A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PMID: 16477365) Kitanaka S … Igarashi T (Journal of human genetics 2006) 3 4 22 58
- Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease. (PMID: 16646680) Hodge SE … Tomer Y (Thyroid : official journal of the American Thyroid Association 2006) 3 22 44 58
- Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PMID: 10199792) Hishinuma A … Ieiri T (The Journal of clinical endocrinology and metabolism 1999) 3 4 22 58
Products for TG Gene
- R&D Systems Antibodies for TG (Thyroglobulin)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs and other biochemical assays for TG (Thyroglobulin)
- Browse Primary Antibodies
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TG
- AM01234PU-N
- AM02238PU-S
- AM02241PU-N
- AM02241PU-S
- AM10040FC-N
- AM10040FC-S
- AM10040PU-N
- AM10040PU-S
- AM10143PU-N
- AM10143PU-S
- AM10143PU-T
- AM20509PU-N
- AM20510PU-N
- AM20511PU-N
- AM31744PU-N
- AM32225SU-N
- AM32241SU-N
- AM32841PU-N
- AM32841PU-S
- AM32841PU-T
- AM33242PU-N
- AM33242PU-S
- AM33242PU-T
- AM33262PU-N
- AM33262PU-S
- AM33262PU-T
- AM50173PU-N
- AM50173PU-S
- AM50173PU-T
- AM50315PU-N
- AM50315PU-S
- AM50315PU-T
- AP02239SU-N
- AP02239SU-S
- AP02240PU-N
- AP02240PU-S
- AP08121PU-N
- AP08121PU-S
- BM160P
- BM733
- DM223
- DM223-05
- DP059
- DP059-05
- TA319577
- TA327746
- TA327747
- TA351796
- TA354119
- TA801456
- CF801456
- TA803991
- CF803991
- TA803992
- CF803992
- TA803993
- CF803993
- TA804165
- CF804165
- TA804166
- CF804166
- CF804211
- TA804212
- CF804212
- TA804213
- CF804213
- TA804214
- CF804214
- TA804215
- CF804215
- TA804254
- CF804254
- TA804255
- CF804255
- TA804257
- CF804257
- TA804258
- CF804258
- TA804297
- CF804297
- TA804361
- CF804361
- TA804362
- TA804409
- CF804409
- TA804410
- CF804410
- TA804620
- CF804620
- TA804642
- CF804642
- TA804834
- CF804834
- TA804211
- CF804209
- TA804209
- CF804167
- TA804167
- Custom Assay ServicesOriGene ELISA Kits for TG
- OriGene Purified Proteins for TG
- Search Origene for MassSpec and Protein Over-expression Lysates for TG
- Origene Custom Protein Services for TG
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TG
- Browse OriGene Inhibitory RNA Products For TG
- OriGene qPCR primer pairs for TG
- OriGene CRISPR knockouts for TG
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TG
- GenScript: Next-day shipping of latest version cDNA ORF clones for TG in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TG
- GenScript Custom Assay Services for TG
- GenScript Custom overexpressing Cell Line Services for TG
- GenScript: Design CRISPR guide RNA sequences for TG
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TG
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TG
- Novus Biologicals proteins for TG
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for TG
- Abcam proteins for TG
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for TG
- Cloud-Clone Corp. Antibodies for TG
- Cloud-Clone Corp. Proteins for TG
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TG
- Cyagen custom Knockout/knockin (KOKI) mouse models for TG
- VectorBuilder custom plasmid, inducible vectors for TG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TG
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 533 available Thyroglobulin Antibodies ranked by validation data
- Compare Top Thyroglobulin Antibodies
- Recommended
- 186 WB Antibodies (anti-human)
- 72 IHC (p) Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 129 WB Antibodies (anti-mouse)
- 17 IHC Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 123 WB Antibodies (anti-rat)
- 16 IHC Antibodies (anti-rat)
- 12 FACS Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- 186 WB Antibodies (anti-human)
- 72 IHC (p) Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 129 WB Antibodies (anti-mouse)
- 17 IHC Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 123 WB Antibodies (anti-rat)
- 16 IHC Antibodies (anti-rat)
- 12 FACS Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 67 available Thyroglobulin Elisa Kits ranked by validation data
- Compare Top Thyroglobulin Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 3 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 2 Hormone ELISA Kits
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 11 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Chicken ELISA Kit
- 3 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 2 Hormone ELISA Kits
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 11 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 14 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 24 available Thyroglobulin Proteins ranked by validation data
- Compare Top Thyroglobulin Proteins
- GeneTex TG antibody for TG
- GeneTex Proteins for TG
- ViGene Biosciences adenoviral particle packaged cDNA for TG gene
- ViGene Biosciences lentiviral particle packaged cDNA for TG gene
- ViGene Biosciences ready-to-package AAV shRNAs for TG gene
- Search ViGene Biosciences for TG
- Santa Cruz Biotechnology (SCBT) Antibodies for TG
- Search Santa Cruz Biotechnology (SCBT) for TG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TG
- Horizon Cell Lines for TG
- genomics-online: cdna clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- orf clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- genomics-online: gRNA clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- genomics-online: primer clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
- genomics-online: shRNA clones - Search results for 78 available Thyroglobulin gene related products
- Overview of 78 available Thyroglobulin gene related products
Sources for TG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (103) GeneReviews
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- (105) Taconic Biosciences
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- (154) HumanCyc
- (155) genomics-online
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