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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TG Gene

protein-coding GIFtS: 58
GCID: GC08P133879

Thyroglobulin

Microbiology & Infectious Diseases Congress

118 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
thyroglobulin¹ ²
AITD3² ⁵
TGN²
Tg³
TDH3⁵

External Ids:	HGNC: 11764¹	Entrez Gene: 7038²	Ensembl: ENSG00000042832⁷	OMIM: 188450⁵	UniProtKB: P01266³

Export aliases for TG gene to outside databases

Previous GC identifers: GC08P132608 GC08P133966 GC08P133550 GC08P133835 GC08P133948 GC08P129197

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TG Gene:

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a

substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of

thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination,

and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid

dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism.

Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as

Graves disease and Hashimoto thryoiditis. (provided by RefSeq, Nov 2009)

GeneCards Summary for TG Gene:

TG (thyroglobulin) is a protein-coding gene. Diseases associated with TG include goiter, and struma ovarii, and among its related super-pathways are Allograft rejection and Insulin secretion. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Gene Wiki entry for TG (Thyroglobulin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NT_008046.16 NC_018919.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TG gene promoter:
COUP-TF1 AP-1 ATF-2 COUP HNF-4alpha2 Nkx2-5 HNF-4alpha1 COUP-TF c-Jun ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TG promoter sequence

Search SABiosciences Chromatin IP Primers for TG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24

TG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TG gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P133879: view genomic region (about GC identifiers)

Start:	133,879,203 bp from pter	End:	134,147,147 bp from pter
Size:	267,945 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266 (See protein sequence)

Recommended Name: Thyroglobulin precursor

Size: 2768 amino acids; 304790 Da

Subunit: Homodimer

Subcellular location: Secreted

Secondary accessions: O15274 O43899 Q15593 Q15948 Q9NYR1 Q9NYR2 Q9UMZ0 Q9UNY3

Alternative splicing: 2 isoforms: P01266-1 P01266-2

Explore the universe of human proteins at neXtProt for TG: NX_P01266

Explore proteomics data for TG at MOPED

Post-translational modifications:

UniProtKB: Sulfated tyrosines are desulfated during iodination

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P01266

TG Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_003226.4

ENSEMBL proteins:

ENSP00000427871 ENSP00000220616 ENSP00000428628 ENSP00000429605 ENSP00000430523

ENSP00000429164 ENSP00000430430 ENSP00000430087 ENSP00000429761 ENSP00000430161

ENSP00000367100 ENSP00000441693

Human Recombinant Protein Products for TG:

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	GenScript Custom Purified and Recombinant Proteins Services for TG
	Novus Biologicals TG Proteins
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for TG
	Cloud-Clone Corp. Proteins for TG

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IBA	--
GO:0005887	NOT integral to plasma membrane	IRD	--
GO:0009986	NOT cell surface	IRD	--
GO:0045202	NOT synapse	IRD	--

TG for ontologies About GeneDecksing

TG Antibody Products:

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Assay Products for TG:

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	Cloud-Clone Corp. ELISAs for TG Cloud-Clone Corp. CLIAs for TG

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro protein domains:

IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

IPR000716 Thyroglobulin_1

IPR019819 Carboxylesterase_B_CS

IPR002018 CarbesteraseB

IPR016324 Thyroglobulin

Graphical View of Domain Structure for InterPro Entry P01266

ProtoNet protein and cluster: P01266

1 Blocks protein domain: IPB000716 Thyroglobulin type-1

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Similarity: Belongs to the type-B carboxylesterase/lipase family

Similarity: Contains 11 thyroglobulin type-1 domains

TG for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: THYG_HUMAN, P01266

Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Genatlas biochemistry entry for TG:

thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004091	NOT carboxylesterase activity	IKR	--
GO:0004872	NOT receptor activity	IRD	--
GO:0005179	hormone activity	IEA	--
GO:0042043	NOT neurexin family protein binding	IRD	--

TG for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tg):

endocrine/exocrine gland

growth/size

hematopoietic system

homeostasis/metabolism

nervous system

TG for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TG

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TG

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TG

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TG

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate TG:
		hsa-miR-1303
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TG
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TG

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		GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TG
		Search LifeMap BioReagents cell lines for TG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TG About

See pathways by source

SuperPath

Contained pathways About

Allograft rejection

Autoimmune thyroid disease

0.62

Insulin secretion

Thyroid hormone synthesis

0.36

Pathways by source See SuperPaths
Show all pathways

2 Kegg Pathways (Kegg details for TG):

	Thyroid hormone synthesis
	Autoimmune thyroid disease

TG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TG

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for TG (P01266³ ENSP00000220616⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPA5	P11021³, ENSP00000324173⁴	I2D: score=4 STRING: ENSP00000324173
ASGR1	P07306³, ENSP00000269299⁴	I2D: score=1 STRING: ENSP00000269299
CTSD	P07339³, ENSP00000236671⁴	I2D: score=1 STRING: ENSP00000236671
APCS	P02743³, ENSP00000255040⁴	I2D: score=1 STRING: ENSP00000255040
CANX	P27824³, ENSP00000247461⁴	I2D: score=1 STRING: ENSP00000247461

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006590	thyroid hormone generation	IBA	--
GO:0007165	signal transduction	NAS	3016640
GO:0007416	NOT synapse assembly	IRD	--
GO:0015705	iodide transport	IEA	--
GO:0030878	thyroid gland development	IEP	15494458

TG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TG (THYG)

10/98 Novoseek inferred chemical compound relationships for TG gene (see all 98) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iodine	91.3	525	1954313 (7), 9292948 (6), 12713257 (4), 19160311 (4) (see all 99)
thyroxine	90.9	582	1466156 (7), 10229914 (6), 11694378 (4), 8890722 (4) (see all 99)
iodide	83.8	155	10537174 (6), 16648292 (4), 19951699 (3), 20364596 (3) (see all 73)
triiodothyronine	83.3	331	11288978 (4), 11694378 (4), 10822292 (4), 16477365 (3) (see all 99)
sodium iodide	78.5	31	19050049 (2), 10090312 (1), 17199440 (1), 18430446 (1) (see all 21)
diiodotyrosine	77.4	15	8900403 (3), 1954313 (1), 8651700 (1), 9717982 (1) (see all 7)
iodotyrosine	73.2	15	15289438 (2), 1727828 (1), 9737985 (1), 1281126 (1) (see all 9)
methimazole	69.9	8	14657389 (1), 1794603 (1), 1688155 (1), 8075781 (1) (see all 5)
thyronine	66.5	6	9434803 (1), 9717982 (1), 9344702 (1), 9419438 (1)
18f fluorodeoxyglucose	60.9	40	12186505 (4), 19910903 (2), 10452315 (2), 12656659 (2) (see all 19)

Search CenterWatch for drugs/clinical trials and news about TG / THYG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TG gene:

NM_003235.4

Unigene Cluster for TG:

Thyroglobulin

Hs.654591 [show with all ESTs]

Unigene Representative Sequence: NM_003235

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000523901 ENST00000220616(uc003ytw.3 uc010mdw.3) ENST00000520769

ENST00000523756(uc011ljb.2) ENST00000518097 ENST00000518505 ENST00000519178

ENST00000518058 ENST00000519543(uc011ljc.2) ENST00000520197 ENST00000520089

ENST00000519294 ENST00000524151 ENST00000522523 ENST00000522797 ENST00000518108

ENST00000522996 ENST00000522809

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TG
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TG:
		hsa-miR-1303
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TG

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		GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TG

Additional mRNA sequence:

AB209159.1 AK299197.1 AK303666.1 AK303667.1 BC127887.1 BC140933.1 S40807.1 S80793.1

X02154.1 X05615.1

24/80 DOTS entries (see all 80):

DT.95202433 DT.95177266 DT.95219259 DT.91713338 DT.100826698 DT.100826700 DT.452683 DT.92472293

DT.120642240 DT.95333374 DT.120642266 DT.100826697 DT.100826709 DT.100826704 DT.120642467 DT.100826710

DT.120642305 DT.120642340 DT.91698313 DT.95333484 DT.100829949 DT.92472287 DT.95333469 DT.95246308

24/1041 AceView cDNA sequences (see all 1041):

BQ355719 AA385311 AU141466 AU141144 AU141984 BE168236 AA384835 AU141734

AU141513 AU159103 AU142105 AU141993 AU141924 AU142090 AA385571 AU141892

AU141941 AU141307 AU141574 AU141761 AU141633 AA385672 AU142009 AU141980

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TG expression in normal human tissues (normalized intensities) TG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TG expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Thyroid (Endocrine System) fully expand to see all 2 entries
Thyroid Progenitors ( Efficient derivation of purified lung and thyroid progenitor...
thyroid gland ; glandular cells

Lung (Respiratory System)
Immature proximal lung cells ( Directed differentiation of human embryonic stem cells...

Gut Tube (Gastrointestinal Tract)
Anterior foregut progenitor cells ( Directed differentiation of human embryonic stem...

Lymph (Hematopoietic System)
Lymphnode

Oral Cavity (Gastrointestinal Tract)
TONGUE

See TG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TG

SOURCE GeneReport for Unigene cluster: Hs.654591

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Tissue specificity: Thyroid gland specific

SABiosciences Expression via Pathway-Focused PCR Array including TG:

Insulin Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TG gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tg^{1 , 5}	thyroglobulin^{1, 5}	78.6(n)¹ 74.35(a)¹		15 (29.30 cM)⁵ 21819¹ NM_009375.2¹ NP_033401.2¹ 66670753⁵
chicken (Gallus gallus)	Aves	TG¹	thyroglobulin	61.24(n) 55.75(a)		100857838 XM_003640868.1 XP_003640916.1
lizard (Anolis carolinensis)	Reptilia	TG⁶	Uncharacterized protein	53(a)	1 ↔ 1	4(662513-807612)
zebrafish (Danio rerio)	Actinopterygii	tg¹	thyroglobulin	50.71(n) 42.07(a)		567631 XM_689200.4 XP_694292.4
fruit fly (Drosophila melanogaster)	Insecta	Est-Q⁶ CG9287⁶ (see all 7)	--	18(a) 18(a) (see all 7)	possible ortholog possible ortholog (see all 7)	3L(21494521-21497059) 2L(8676848-8679782)
worm (Caenorhabditis elegans)	Secernentea	F55F3.2⁶ E01G6.3⁶ (see all 23)	Protein E01G6.3 (see all 23)	20(a) 19(a) (see all 23)	possible ortholog possible ortholog (see all 23)	X(13760290-13763993) X(12241716-12244652)

ENSEMBL Gene Tree for TG (if available)
TreeFam Gene Tree for TG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TG gene

9 SIMAP similar genes for TG using alignment to 13 protein entries: THYG_HUMAN (see all proteins):

NLGN2 CES2 CES3 CES5A NLGN3 DKFZp686F02202

ACHE BCHE CES1P1

TG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_063037⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063037	2	R Q	mis⁴		0	--	--	--	--
VAR_063035⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063035	2	C Y	mis⁴		0	--	--	--	--
VAR_063036⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063036	2	A D	mis⁴		0	--	--	--	--
VAR_063034⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063034	2	C Y	mis⁴		0	--	--	--	--
VAR_063038⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063038	2	G R	mis⁴		0	--	--	--	--
rs2076738^1,2,4	C,H	Thyroid dyshormonogenesis 3 (TDH3)⁴ --	134192929(+)	`TGATAT/CGTAGC`	2	/R /C	mis¹ ese³		7		EA NS NA	644
rs2076739^1,2,4	C	Thyroid dyshormonogenesis 3 (TDH3)⁴ pathogenic¹	134257890(+)	`TTGAAT/AGTGAA`	2	/S /C	mis¹		1		EA	220
rs121912648^1,2	C,F	pathogenic¹	134168695(+)	`GATTCC/TGATGT`	2	R *	stg¹		2		NA EU	5871
rs121912646^1,2	C	pathogenic¹	134209483(+)	`AGTATC/TGAGCC`	2	R *	stg¹		0	--	--	--	--
rs2069566^1,2,4	C	pathogenic¹	134304022(+)	`GAGGCG/ACTTCC`	2	/H /R	mis¹ ese³		3		EA NA	20

HapMap Linkage Disequilibrium report for TG (133879203 - 134129203 bp, first 250kb of TG)

Structural Variations
Database of Genomic Variants (DGV) 10/18 variations for TG (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2622999	CNV	Insertion	19546169
nsv509279	CNV	Insertion	20534489
esv1530894	CNV	Insertion	17803354
nsv6403	CNV	Insertion	18451855
nsv6402	CNV	Insertion	18451855
nsv891456	CNV	Loss	21882294
nsv525105	CNV	Loss	19592680
esv33367	CNV	Loss	17666407
nsv465818	CNV	Loss	19166990
esv33561	CNV	Loss	17666407

Human Gene Mutation Database (HGMD): TG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TG

DNA2.0 Custom Variant and Variant Library Synthesis for TG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 188450
OMIM disorders: 274700 608175
UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing

large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid

dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a

relatively high serum free triiodothyronine (T3) concentration with disproportionately low free

tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue

hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and

intellectual defects in some cases. Note=The disease is caused by mutations affecting the gene represented in

this entry

Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related

diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive

T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2

differentiation and activate B cells to produce antibodies against the TSH receptor, which stimulate the thyroid

and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the

thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.

Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

20/118 diseases for TG (see all 118): About MalaCards

goiter struma ovarii endemic goiter nontoxic goiter

malignant struma ovarii laryngocele suppurative thyroiditis thyroid dyshormonogenesis 3

hypothyroidism autoimmune thyroiditis graves' disease hashimoto's encephalitis

thyroxine-binding globulin deficiency iodine hypothyroidism subacute thyroiditis nodular goiter

myxedema non-herpetic acute limbic encephalitis toxic diffuse goiter multinodular goiter

12 diseases from the University of Copenhagen DISEASES database for TG:

Thyroid cancer Autoimmune thyroiditis Goiter Hypothyroidism

Hyperthyroidism Thyrotoxicosis Subacute thyroiditis Carcinoma

Thyroid adenoma Adenoma Teratoma Suppurative thyroiditis

TG for disorders About GeneDecksing

10/95 Novoseek inferred disease relationships for TG gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma	95.4	414	17892441 (5), 18630997 (4), 19160311 (4), 11325833 (3), 18284635 (3), 18098308 (3), 15212646 (3), 8157713 (3), 19743952 (3), 9641890 (3), 9854590 (3), 9804398 (3), 17505148 (3), 15579752 (2), 15670185 (2), 1947763 (2), 14759077 (2), 10411121 (2), 8288703 (2), 16794517 (2), 18682151 (2), 17115345 (2), 2145560 (2), 17665659 (2), 16595825 (2), 15985472 (2), 9591591 (2), 1305063 (2), 2040337 (2), 16116831 (2), 15251954 (2), 12915653 (2), 11727628 (2), 11437410 (2), 10487692 (2), 15972576 (2), 15994745 (2), 11585858 (2), 10524571 (2), 1466156 (2), 18758416 (2), 17278897 (2), 15765025 (2), 9508203 (2), 1352334 (2), 20017617 (2), 8350939 (2), 16434461 (2), 15841300 (2), 15157556 (2), 10792347 (2), 9670628 (2), 19589101 (2), 17006838 (2), 16574765 (2), 17726546 (2), 1859419 (1), 8510876 (1), 7829158 (1), 7833657 (1), 7580263 (1), 10543413 (1), 10727001 (1), 18528186 (1), 17971424 (1), 18060877 (1), 17578824 (1), 17609408 (1), 17270168 (1), 17077133 (1), 17021427 (1), 16509525 (1), 8635854 (1), 8565221 (1), 7528064 (1), 8168197 (1), 1524008 (1), 1574029 (1), 1780240 (1), 20096208 (1), 17460457 (1), 17684621 (1), 17123341 (1), 16922467 (1), 15701340 (1), 15761510 (1), 15232654 (1), 14557460 (1), 14530610 (1), 12965943 (1), 14557483 (1), 11370541 (1), 10989968 (1), 10365673 (1), 10219505 (1), 8970514 (1), 8787961 (1), 7570041 (1), 15251584 (1) (see top 4)
thyroid cancer	95	436	17302864 (4), 14588101 (3), 16479246 (3), 18613899 (3), 19769825 (3), 11061512 (3), 16033735 (3), 17100547 (3), 12782763 (3), 19154731 (3), 17710020 (3), 10566646 (3), 11974529 (3), 12542917 (3), 12193302 (3), 1561118 (2), 18759693 (2), 19636213 (2), 9920363 (2), 14973426 (2), 8970514 (2), 7688705 (2), 18769305 (2), 18090216 (2), 16681439 (2), 15105893 (2), 11836297 (2), 11197983 (2), 15251954 (2), 12641624 (2), 18207685 (2), 18426828 (2), 18166820 (2), 17555505 (2), 17279579 (2), 15497927 (2), 15094441 (2), 12843145 (2), 10404792 (2), 2292657 (2), 20353278 (2), 15695326 (2), 15256244 (2), 19383064 (2), 17956163 (2), 16187918 (2), 15157556 (2), 14870781 (2), 12699436 (2), 11301345 (2), 1881285 (2), 17524307 (2), 15797967 (2), 18268520 (2), 18097251 (2), 10090308 (2), 1341479 (2), 8086348 (1), 7833657 (1), 15283689 (1), 15271884 (1), 15640776 (1), 17077133 (1), 14654967 (1), 14605601 (1), 12813190 (1), 12773129 (1), 12206749 (1), 12029550 (1), 11729387 (1), 11325833 (1), 8177601 (1), 1862697 (1), 2040337 (1), 19961815 (1), 19910901 (1), 19607742 (1), 19551443 (1), 19577460 (1), 18685889 (1), 19169488 (1), 15762184 (1), 15701340 (1), 15232654 (1), 15232708 (1), 15181134 (1), 14604064 (1), 14588100 (1), 12142399 (1), 11158054 (1), 15251584 (1), 8222585 (1), 2005446 (1), 2090795 (1), 1699752 (1), 19851169 (1), 19910900 (1), 16895961 (1), 15830368 (1) (see top 4)
autoimmune thyroid disease	92.8	143	10570317 (3), 15096179 (3), 2256432 (2), 14973426 (2), 8102254 (2), 7889607 (2), 11441999 (2), 16704751 (2), 19050049 (2), 10436985 (2), 18656705 (2), 2015711 (1), 8014070 (1), 8933281 (1), 10601957 (1), 10090312 (1), 11308045 (1), 11695307 (1), 1862697 (1), 1983329 (1), 2311297 (1), 16761373 (1), 15793184 (1), 15579800 (1), 15008998 (1), 11788684 (1), 10718822 (1), 7711504 (1), 8457287 (1), 18178059 (1), 7533775 (1), 8258649 (1), 1954313 (1), 1713250 (1), 2022716 (1), 18299471 (1), 8752947 (1), 8330876 (1), 8467565 (1), 1476872 (1), 2307728 (1), 19947439 (1), 19034705 (1), 15544618 (1), 14657345 (1), 20215770 (1), 19776016 (1), 12780685 (1), 11297604 (1), 11129117 (1), 10987206 (1), 1721014 (1), 19284442 (1), 17223970 (1), 16756470 (1), 11736644 (1), 10403182 (1), 9398743 (1), 1698387 (1), 2153531 (1), 11454506 (1), 9183516 (1), 7852506 (1), 16945360 (1), 12965943 (1), 12864796 (1), 10826964 (1), 9737357 (1), 8565220 (1), 7528064 (1), 1424209 (1), 14971052 (1), 16335671 (1), 17725430 (1), 18029466 (1), 1571480 (1), 8424429 (1), 9545109 (1) (see top 4)
hashimotos thyroiditis	90.5	101	2242608 (3), 2226281 (2), 10670755 (2), 7962336 (2), 8966023 (2), 2256432 (1), 7833663 (1), 7580263 (1), 1720958 (1), 10071095 (1), 11129113 (1), 10826964 (1), 7528064 (1), 7687977 (1), 17143095 (1), 16206515 (1), 14678262 (1), 12213909 (1), 10502541 (1), 8999299 (1), 7742656 (1), 8102254 (1), 1724912 (1), 19264867 (1), 17823263 (1), 12848961 (1), 10347809 (1), 9344706 (1), 10482377 (1), 10436985 (1), 9068951 (1), 7743674 (1), 18095494 (1), 17223970 (1), 16602033 (1), 16756470 (1), 7829613 (1), 20215770 (1), 10745983 (1), 9218533 (1), 8752947 (1), 7579533 (1), 1373164 (1), 20477052 (1), 12780685 (1), 10987206 (1), 8187321 (1), 1284333 (1), 1698387 (1), 19667753 (1), 19050049 (1), 18656705 (1), 16704751 (1), 9183516 (1), 8258649 (1), 8094394 (1), 1481387 (1), 1726441 (1), 2101432 (1), 2107049 (1), 12965943 (1), 12553558 (1), 10570317 (1), 7527743 (1), 8443962 (1), 1915118 (1), 10984889 (1), 14971052 (1), 18029466 (1) (see top 4)
graves disease	89.4	145	16646680 (3), 1724781 (2), 10984889 (2), 11092696 (2), 11454506 (2), 1688155 (2), 18762990 (2), 2166430 (2), 11751544 (2), 1978459 (2), 7743674 (2), 10876005 (2), 2256432 (1), 8104224 (1), 12444888 (1), 14971052 (1), 18029466 (1), 2242608 (1), 1705860 (1), 2080137 (1), 18482926 (1), 17198353 (1), 10999849 (1), 10570317 (1), 8966023 (1), 7527743 (1), 8443962 (1), 18656705 (1), 10229914 (1), 9183516 (1), 7742656 (1), 8102254 (1), 18755875 (1), 17823263 (1), 10347809 (1), 7516033 (1), 16440775 (1), 10745983 (1), 10483254 (1), 10690629 (1), 8752947 (1), 7911812 (1), 7910048 (1), 1373164 (1), 8020185 (1), 19474733 (1), 18385936 (1), 18379045 (1), 1683085 (1), 2096159 (1), 2360457 (1), 17223970 (1), 16602033 (1), 16756470 (1), 10824047 (1), 10482369 (1), 1689529 (1), 8364879 (1), 12780685 (1), 10987206 (1), 10946880 (1), 10436985 (1), 9754221 (1), 9329373 (1), 7608274 (1), 7829613 (1), 8101679 (1), 1284333 (1), 1698387 (1), 1696557 (1), 8258649 (1), 7688705 (1), 2107049 (1), 18243140 (1), 15600194 (1), 14657389 (1), 12965943 (1), 7528064 (1), 1974494 (1), 17243910 (1), 12667218 (1), 7988028 (1), 7833663 (1), 7487672 (1), 9849814 (1) (see top 4)
thyroid diseases	89.1	126	18243140 (4), 10984889 (3), 11228272 (3), 12022704 (3), 9508203 (3), 8388753 (2), 7539201 (2), 8957481 (2), 7528064 (2), 1752339 (2), 10229914 (2), 10483254 (2), 8722578 (2), 8058301 (2), 16936513 (2), 2256432 (1), 12444888 (1), 16772197 (1), 7527743 (1), 8697622 (1), 10999849 (1), 2318474 (1), 19939287 (1), 18787379 (1), 12553558 (1), 11438400 (1), 11272097 (1), 9868291 (1), 7994910 (1), 8157713 (1), 11148327 (1), 10987206 (1), 10403176 (1), 9068951 (1), 8548999 (1), 1619946 (1), 19079713 (1), 9398743 (1), 2092906 (1), 10745983 (1), 8124482 (1), 18019649 (1), 17785297 (1), 14696848 (1), 16704751 (1), 14981996 (1), 12782763 (1), 9284706 (1), 8543331 (1), 18052943 (1), 17506473 (1), 15203250 (1), 7749502 (1), 7829613 (1), 8306534 (1), 1284333 (1), 1385030 (1), 14633662 (1), 14669943 (1), 14557483 (1), 11519462 (1), 10940722 (1), 10433080 (1), 9411419 (1), 1951413 (1), 8966023 (1), 7549998 (1), 18029466 (1), 16042141 (1), 7569734 (1), 7833663 (1), 1867098 (1) (see top 4)
goiter	88.5	123	2129364 (4), 1851064 (4), 7549998 (3), 9588493 (2), 16218041 (2), 2000697 (2), 7711505 (2), 16187918 (2), 1318692 (2), 18598585 (2), 10235039 (2), 8981932 (2), 20093166 (2), 1752952 (2), 1397384 (2), 7793989 (2), 8616533 (1), 10025449 (1), 10523025 (1), 12899791 (1), 8325944 (1), 16405252 (1), 16444154 (1), 15913449 (1), 9398747 (1), 7628349 (1), 8050126 (1), 17532758 (1), 16187910 (1), 19554808 (1), 18187871 (1), 18075286 (1), 17977395 (1), 16405406 (1), 12915634 (1), 10907993 (1), 10821321 (1), 10776989 (1), 19762181 (1), 18565420 (1), 17338121 (1), 16335774 (1), 15572417 (1), 10426591 (1), 9790265 (1), 8777378 (1), 1915109 (1), 2361565 (1), 9760285 (1), 9514162 (1), 9464451 (1), 7604491 (1), 2302248 (1), 16704751 (1), 15807875 (1), 12864801 (1), 8196172 (1), 7951537 (1), 8325250 (1), 2116437 (1), 2375236 (1), 17911408 (1), 12685194 (1), 11378813 (1), 11128728 (1), 8626865 (1), 7742656 (1), 7988459 (1), 1688155 (1), 12762640 (1), 10404833 (1), 9707574 (1), 11873391 (1), 7839886 (1), 7920005 (1), 19194833 (1), 15531495 (1), 14524121 (1), 8661844 (1) (see top 4)
goiter congenital	88.5	55	10199792 (3), 14764776 (2), 8325944 (2), 15769978 (2), 1726786 (2), 9292947 (1), 1727828 (1), 1975692 (1), 8050126 (1), 9707574 (1), 16477365 (1), 12915634 (1), 8981932 (1), 8325250 (1), 10403182 (1), 7604491 (1), 2096156 (1), 20093166 (1), 16720658 (1), 1752952 (1), 19633549 (1), 9790265 (1), 8777378 (1), 1915109 (1), 20089614 (1), 19438905 (1), 16271015 (1), 17062458 (1), 15171721 (1), 1397384 (1), 7635972 (1), 16042141 (1), 9588493 (1) (see top 4)
hypothyroidism	88.4	117	9790265 (3), 15014299 (2), 8966023 (2), 17978827 (2), 16184253 (2), 8777378 (2), 20375239 (2), 18631008 (2), 15769978 (2), 9588493 (1), 11389291 (1), 15387978 (1), 16296342 (1), 19337173 (1), 2258580 (1), 15687823 (1), 16405252 (1), 15761510 (1), 15243406 (1), 14763906 (1), 14565053 (1), 12542401 (1), 11041454 (1), 9881901 (1), 16187910 (1), 15604941 (1), 15751925 (1), 19509106 (1), 17823263 (1), 16394083 (1), 10404833 (1), 9707574 (1), 8837335 (1), 7883851 (1), 8325250 (1), 2149997 (1), 18945587 (1), 18095494 (1), 16543988 (1), 15350757 (1), 11729583 (1), 8936677 (1), 8778159 (1), 18363882 (1), 17060029 (1), 16676403 (1), 15572417 (1), 7621572 (1), 7695146 (1), 8263143 (1), 20089614 (1), 19438905 (1), 19762181 (1), 19554808 (1), 18332849 (1), 18075286 (1), 16628280 (1), 12915634 (1), 11257722 (1), 9198970 (1), 8196172 (1), 1726786 (1), 1696557 (1), 20093166 (1), 17956163 (1), 17053394 (1), 16704751 (1), 16261894 (1), 15689747 (1), 7868803 (1), 8327640 (1), 8094394 (1), 1472644 (1), 1348235 (1), 1987438 (1), 19910900 (1), 19265500 (1), 8733874 (1), 1727828 (1), 2254721 (1), 16806791 (1), 15670185 (1), 11874417 (1), 14764776 (1) (see top 4)
thyroid papillary carcinoma	87.6	64	15579752 (2), 1305063 (2), 16033735 (2), 16201895 (2), 10718554 (2), 11745281 (2), 12641624 (2), 17645579 (2), 7539201 (1), 18029466 (1), 10999849 (1), 11303631 (1), 16550594 (1), 20080852 (1), 14513322 (1), 10074219 (1), 8478715 (1), 16940367 (1), 16571089 (1), 16091757 (1), 10420227 (1), 1297527 (1), 20463837 (1), 11967907 (1), 10946899 (1), 10754474 (1), 11304850 (1), 20518406 (1), 15829073 (1), 15671775 (1), 18710471 (1), 11064390 (1), 11325833 (1), 12819023 (1), 14605601 (1), 18636294 (1), 20096208 (1) (see top 4)

Genatlas disease: TG

goiter associated to hypothyroidism and variant type of adenomatous goiter

Genetic Association Database (GAD): TG
Human Genome Epidemiology (HuGE) Navigator: TG (885 documents)

Export disorders for TG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TG gene, integrated from 9 sources (see all 1762):
(articles sorted by number of sources associating them with TG)

Utopia: connect your pdf to the dynamic
world of online information

The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PubMed id 19509106)^{1, 2, 9} Pardo V.... Medeiros-Neto G. (2009)
Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PubMed id 10199792)^{1, 2, 9} Hishinuma A.... Ieiri T. (1999)
Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent- exposed regions of the primary structure. (PubMed id 8269951)^{1, 2, 9} Gentile F. and Salvatore G. (1993)
A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PubMed id 16477365)^{1, 2, 9} Kitanaka S....Igarashi T. (2006)
Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. (PubMed id 8797845)^{1, 2, 9} Molina F.... Granier C. (1996)
Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. (PubMed id 7793989)^{1, 2, 9} Xiao S.... Rawitch A.B. (1995)
Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes. (PubMed id 20215770)^{1, 4, 9} Kotnik P....Battelino T. (2010)
Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. (PubMed id 19034705)^{1, 4, 9} Maierhaba M....Dong B.N. (2008)
Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. (PubMed id 18385936)^{1, 4, 9} Hsiao J.Y....Ke D.S. (2008)
Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. (PubMed id 18755875)^{1, 4, 9} Hsiao J.Y....Ke D.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7038	HGNC: 11764	AceView: TG	Ensembl:ENSG00000042832	euGenes: HUgn7038
ECgene: TG	Kegg: 7038	H-InvDB: TG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TG	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Thyroglobulin

Intellectual Property for TG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TG gene:
Search GeneIP for patents involving TG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	RT² qPCR Primer Assay in human, mouse, rat TG
	GNC Network for TG
	SABiosciences PCR Arrays including human, mouse, rat TG

Search Tocris compounds for TG (THYG)

	Browse Sino Biological Proteins and Antibodies
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	Protein Production Services
	Transfection Reagents
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TG antibodies
	TG proteins

	Antibodies for TG
	See all of Abcam's Antibodies, Kits and Proteins for TG
	Custom Antibody / Protein Production Service
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Recombinant Protein for TG

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Search LifeMap BioReagents cell lines for TG

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TG
	SwitchGear Promoter luciferase reporter plasmids for TG

ThermoFisher Antibody for TG

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TG
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TG

Customized:

	lentivirus for stable overexpression
	lentivirus expression plasmids for stable overexpression
	adenovirus for overexpression

LSBio Antibodies in human, mouse, rat for TG

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TG gene at Home site.

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TG Gene

Thyroglobulin

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recurrent cancer
stable disease
Pregnancy loss
Toxic diffuse goiter
Genetic Susceptibility
Acquired hypothyroidism
THYROID CARCINOMA ANAPLASTIC
PAPILLARY THYROID MICROCARCINOMA
Residual Cancer
Urticaria chronic
THYROID FOLLICULAR CARCINOMA
Thyroid Nodule
lung metastases
THYROID HORMONE RESISTANCE
Carcinoma Papillary Follicular
Turners Syndrome
Thyroid-Associated Ophthalmopathy
THYROID ECTOPIC
Hyperthyroidism
HYPOTHYROIDISM PRIMARY
primary tumor
GOITER CONGENITAL
THYROID CARCINOMA MEDULLARY
Cancer
Diabetes Mellitus Insulin-Dependent
multinodular goiter
GOITER COLLOID
THYROGLOBULIN SYNTHESIS DEFECT
Anemia Pernicious
follicular thyroid cancer
toxic adenoma
Congenital hypothyroidism
recurrent thyroid cancer
Thyroid Neoplasms
Nontoxic multinodular goiter
cancer recurrence
Iodine deficiency
THYROID CARCINOMA, HURTHLE CELL
Tumors
THYROID CYST
Metastasis
Autoimmunity
Celiac Disease
Thyroid dysfunction postpartum
TBG, SERUM
Thyroiditis
Ovarian Neoplasms
Endemic goiter
Autoimmune Diseases
Thyroid Storm
Adenoma Follicular
THYROTOXICOSIS FACTITIA
Goiter Nodular
Multiple Endocrine Neoplasia
Carcinoma Mucoepidermoid
GOITER TOXIC NODULAR
Carcinoma
Hypothyroidism
Addisons Disease
Thyroid Cancer
METASTATIC CARCINOMA
metastatic cancer
Carcinoma Papillary
Carcinoid
Carcinoma Anaplastic
THYROID PAPILLARY CARCINOMA
Goiter
Paraganglioma
Nontoxic goiter
Thyroiditis Subacute
THYROID ADENOMA
Adenoma Trabecular
Carcinoma Undifferentiated
GOITER ADENOMATOUS
diffuse goiter
Adenoma
Carcinoma Medullary
Thyroid Diseases
autoimmune thyroid disease
Struma Ovarii
Histopathology
papillary thyroid cancer
GOITER EUTHYROID
TSH DEFICIENCY
Autoimmune Response
Graves Disease
DYSFUNCTION THYROID
PENDRED SYNDROME
residual disease
Thyroiditis Chronic
Hashimotos Thyroiditis
THYROID CARCINOMA
Myxedema
bone metastases
CERVICAL CYST

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Export list of displayed genes

TG Gene

Thyroglobulin

Aliasesfor TG gene

Summariesfor TG gene

Genomic Viewsfor TG gene

Proteinsfor TG gene

Protein Domains /Familiesfor TG gene

Functionfor TG gene

Pathways & Interactionsfor TG gene

Drugs & Compoundsfor TG gene

Transcriptsfor TG gene

Expression for TG gene

Orthologsfor TG gene

Paralogsfor TG gene

Genomic Variantsfor TG gene

Disorders / Diseasesfor TG gene

Publicationsfor TG gene

External Searches for TG gene

Genome Databases showing TG gene

Other Databases showing TG gene

Specialized Databases showing TG gene

Intellectual Propertyfor TG gene

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Aliases
for TG gene

Summaries
for TG gene

Genomic Views
for TG gene

Proteins
for TG gene

Protein Domains /
Families
for TG gene

Function
for TG gene

Pathways & Interactions
for TG gene

Drugs & Compounds
for TG gene

Transcripts
for TG gene

Expression
for TG gene

Orthologs
for TG gene

Paralogs
for TG gene

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for TG gene

Disorders / Diseases
for TG gene

Publications
for TG gene

Intellectual Property
for TG gene

Products
for TG gene