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Set Analyses:

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TG Gene

protein-coding GIFtS: 59
GCID: GC08P133879

Thyroglobulin

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
thyroglobulin¹ ²
AITD3² ⁵
TGN²
Tg³
TDH3⁵

External Ids:	HGNC: 11764¹	Entrez Gene: 7038²	Ensembl: ENSG00000042832⁷	OMIM: 188450⁵	UniProtKB: P01266³

Export aliases for TG gene to outside databases

Previous GC identifers: GC08P132608 GC08P133966 GC08P133550 GC08P133835 GC08P133948 GC08P129197

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TG Gene:

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a

substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of

thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination,

and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid

dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism.

Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as

Graves disease and Hashimoto thryoiditis. (provided by RefSeq, Nov 2009)

GeneCards Summary for TG Gene:

TG (thyroglobulin) is a protein-coding gene. Diseases associated with TG include suppurative thyroiditis, and autoimmune thyroid disease 3. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Gene Wiki entry for TG (Thyroglobulin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000008.11 NT_008046.17 NC_018919.2

Regulatory elements:

Regulatory transcription factor binding sites in the TG gene promoter:
COUP-TF1 AP-1 ATF-2 COUP HNF-4alpha2 Nkx2-5 HNF-4alpha1 COUP-TF c-Jun ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TG promoter sequence

Search Chromatin IP Primers for TG

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24

TG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TG gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P133879: view genomic region (about GC identifiers)

Start:	133,879,203 bp from pter	End:	134,147,147 bp from pter
Size:	267,945 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THYG_HUMAN, P01266 (See protein sequence)

Recommended Name: Thyroglobulin precursor

Size: 2768 amino acids; 304790 Da

Subunit: Homodimer

Secondary accessions: O15274 O43899 Q15593 Q15948 Q9NYR1 Q9NYR2 Q9UMZ0 Q9UNY3

Alternative splicing: 2 isoforms: P01266-1 P01266-2

Explore the universe of human proteins at neXtProt for TG: NX_P01266

Explore proteomics data for TG at MOPED

Post-translational modifications:

Sulfated tyrosines are desulfated during iodination¹

Glycosylation² at Asn76, Asn198, Asn484, Asn529, Asn748, Asn816, Asn947, Asn1220, Asn1348, Asn1349,
Asn1365, Asn1716, Asn1774, Asn2013, Asn2250, Asn2295, Asn2582, Ser2749

Modification sites at PhosphoSitePlus

See TG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003226.4

ENSEMBL proteins:

ENSP00000427871 ENSP00000220616 ENSP00000428628 ENSP00000429605 ENSP00000430523

ENSP00000429164 ENSP00000430430 ENSP00000430087 ENSP00000429761 ENSP00000430161

ENSP00000367100 ENSP00000441693

TG Human Recombinant Protein Products:

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	OriGene Purified Protein for TG Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for TG
	GenScript Custom Purified and Recombinant Proteins Services for TG
	Novus Biologicals TG Proteins
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for TG
	Cloud-Clone Corp. Proteins for TG

TG Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for TG OriGene Custom Antibody Services for TG
	Novus Biologicals TG Antibodies
	Abcam antibodies for TG
	Cloud-Clone Corp. Antibodies for TG
	ThermoFisher Antibody for TG
	LSBio Antibodies in human, mouse, rat for TG

TG Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TG
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TG
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TG Cloud-Clone Corp. CLIAs for TG

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

IPR000716 Thyroglobulin_1

IPR019819 Carboxylesterase_B_CS

IPR002018 CarbesteraseB

IPR016324 Thyroglobulin

Graphical View of Domain Structure for InterPro Entry P01266

ProtoNet protein and cluster: P01266

1 Blocks protein domain: IPB000716 Thyroglobulin type-1

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Similarity: Belongs to the type-B carboxylesterase/lipase family

Similarity: Contains 11 thyroglobulin type-1 domains

TG for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: THYG_HUMAN, P01266

Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Genatlas biochemistry entry for TG:

thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	NOT receptor activity	IRD	--
GO:0005179	hormone activity	IEA	--
GO:0042043	NOT neurexin family protein binding	IRD	--

TG for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tg):

endocrine/exocrine gland

growth/size/body

hematopoietic system

homeostasis/metabolism

nervous system

TG for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TG

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TG

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TG

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TG

miRNA Products:		miRTarBase miRNAs that target TG: hsa-let-7f-5p (MIRT032091)

		Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate TG:
		hsa-miR-1303
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TG
		Predesigned siRNA for gene silencing in human, mouse, rat TG

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TG

Clone Products:		OriGene clones in human, mouse for TG (see all 5) OriGene ORF clones in mouse, rat for TG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TG
		Browse ESI BIO Cell Lines and PureStem Progenitors for TG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

THYG_HUMAN, P01266: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
endoplasmic reticulum	3
plasma membrane	3
cytoskeleton	2
golgi apparatus	2
lysosome	2
mitochondrion	2
nucleus	2
vacuole	2
cytosol	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IBA	--
GO:0005887	NOT integral component of plasma membrane	IRD	--
GO:0009986	NOT cell surface	IRD	--
GO:0045202	NOT synapse	IRD	--

TG for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TG About

See pathways by source

SuperPath

Contained pathways About

Allograft rejection

Autoimmune thyroid disease

0.61

Insulin secretion

Thyroid hormone synthesis

0.36

Thyroxine (Thyroid Hormone) Production

Thyroxine (Thyroid Hormone) Production

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for TG

Thyroxine (Thyroid Hormone) Production

2 Kegg Pathways (Kegg details for TG):

	Thyroid hormone synthesis
	Autoimmune thyroid disease

TG for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including TG:

Insulin Signaling Pathway in human mouse rat

Interactions:

GeneGlobe Interaction Network for TG

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for TG (P01266³ ENSP00000220616⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPA5	P11021³, ENSP00000324173⁴	I2D: score=4 STRING: ENSP00000324173
ASGR1	P07306³, ENSP00000269299⁴	I2D: score=1 STRING: ENSP00000269299
CTSD	P07339³, ENSP00000236671⁴	I2D: score=1 STRING: ENSP00000236671
APCS	P02743³, ENSP00000255040⁴	I2D: score=1 STRING: ENSP00000255040
CANX	P27824³, ENSP00000247461⁴	I2D: score=1 STRING: ENSP00000247461

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Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006590	thyroid hormone generation	IBA	--
GO:0007165	signal transduction	NAS	3016640
GO:0007416	NOT synapse assembly	IRD	--
GO:0015705	iodide transport	IEA	--
GO:0030878	thyroid gland development	IEP	15494458

TG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TG (THYG)

Selected Novoseek inferred chemical compound relationships for TG gene (see all 98) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iodine	91.3	525	1954313 (7), 9292948 (6), 12713257 (4), 19160311 (4) (see all 99)
thyroxine	90.9	582	1466156 (7), 10229914 (6), 11694378 (4), 8890722 (4) (see all 99)
iodide	83.8	155	10537174 (6), 16648292 (4), 19951699 (3), 20364596 (3) (see all 73)
triiodothyronine	83.3	331	11288978 (4), 11694378 (4), 10822292 (4), 16477365 (3) (see all 99)
sodium iodide	78.5	31	19050049 (2), 10090312 (1), 17199440 (1), 18430446 (1) (see all 21)
diiodotyrosine	77.4	15	8900403 (3), 1954313 (1), 8651700 (1), 9717982 (1) (see all 7)
iodotyrosine	73.2	15	15289438 (2), 1727828 (1), 9737985 (1), 1281126 (1) (see all 9)
methimazole	69.9	8	14657389 (1), 1794603 (1), 1688155 (1), 8075781 (1) (see all 5)
thyronine	66.5	6	9434803 (1), 9717982 (1), 9344702 (1), 9419438 (1)
18f fluorodeoxyglucose	60.9	40	12186505 (4), 19910903 (2), 10452315 (2), 12656659 (2) (see all 19)

TG for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TG gene:

NM_003235.4

Unigene Cluster for TG:

Thyroglobulin

Hs.654591 [show with all ESTs]

Unigene Representative Sequence: NM_003235

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000523901 ENST00000220616(uc003ytw.3 uc010mdw.3) ENST00000520769

ENST00000523756(uc011ljb.2) ENST00000518097 ENST00000518505 ENST00000519178

ENST00000518058 ENST00000519543(uc011ljc.2) ENST00000520197 ENST00000520089

ENST00000519294 ENST00000524151 ENST00000522523 ENST00000522797 ENST00000518108

ENST00000522996 ENST00000522809

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate TG:
		hsa-miR-1303
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TG
		Predesigned siRNA for gene silencing in human, mouse, rat TG

Clone Products:		OriGene clones in human, mouse for TG (see all 5) OriGene ORF clones in mouse, rat for TG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TG
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TG
		QuantiTect SYBR Green Assays in human, mouse, rat TG
		QuantiFast Probe-based Assays in human, mouse, rat TG

Additional mRNA sequence:

AB209159.1 AK299197.1 AK303666.1 AK303667.1 BC127887.1 BC140933.1 S40807.1 S80793.1

X02154.1 X05615.1

Selected DOTS entries (see all 80):

DT.95202433 DT.95177266 DT.95219259 DT.91713338 DT.100826698 DT.100826700 DT.452683 DT.92472293

DT.120642240 DT.95333374 DT.120642266 DT.100826697 DT.100826709 DT.100826704 DT.120642467 DT.100826710

DT.120642305 DT.120642340 DT.91698313 DT.95333484 DT.100829949 DT.92472287 DT.95333469 DT.95246308

Selected AceView cDNA sequences (see all 1041):

AU141761 AA384674 AU141693 AU142018 AU141921 AU141623 AU141456 AU141850

AU141264 AU141642 AA384456 BE168159 AU141713 AU141584 AA385241 AU141981

AU141691 AU141975 AA385060 AU142003 AU141892 AU141459 AU141307 AU141980

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TG expression in normal human tissues (normalized intensities) TG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TG expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Thyroid (Endocrine System)
Thyroid Progenitors

Gut Tube (Gastrointestinal Tract)
Anterior foregut progenitor cells

Lung (Respiratory System)
Immature proximal lung cells

Larynx (Respiratory System)

TG Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TG Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654591

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Tissue specificity: Thyroid gland specific

Pathway & Disease-focused RT² Profiler PCR Array including TG:

Insulin Signaling Pathway in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TG
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TG
		QuantiTect SYBR Green Assays in human, mouse, rat TG
		QuantiFast Probe-based Assays in human, mouse, rat TG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TG gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tg^{1 , 5}	thyroglobulin^{1, 5}	78.6(n)¹ 74.35(a)¹		15 (29.30 cM)⁵ 21819¹ NM_009375.2¹ NP_033401.2¹ 66670753⁵
chicken (Gallus gallus)	Aves	TG¹	thyroglobulin	61.3(n) 55.62(a)		100857838 XM_003640868.2 XP_003640916.2
lizard (Anolis carolinensis)	Reptilia	TG⁶	thyroglobulin	53(a)	1 ↔ 1	4(662513-807612)
tropical clawed frog (Xenopus tropicalis)	Amphibia	tg¹	thyroglobulin	55.55(n) 48.51(a)		100492021 XM_002939515.2 XP_002939561.2
zebrafish (Danio rerio)	Actinopterygii	tg¹	thyroglobulin	52.54(n) 44.44(a)		567631 XM_689200.5 XP_694292.5
fruit fly (Drosophila melanogaster)	Insecta	alpha-Est8⁶	alpha-Esterase-8	18(a)	1 → many	3R(3335065-3341391)
worm (Caenorhabditis elegans)	Secernentea	Y75B8A.3⁶	Protein Y75B8A.3 (Y75B8A.3) mRNA, complete cds	12(a)	1 ↔ 1	III(12101745-12106535) WBGene00013540

ENSEMBL Gene Tree for TG (if available)
TreeFam Gene Tree for TG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TG gene

9 SIMAP similar genes for TG using alignment to 13 protein entries: THYG_HUMAN (see all proteins):

NLGN2 CES2 CES3 CES5A NLGN3 DKFZp686F02202

ACHE BCHE CES1P1

TG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2076738^1,2,,4	C,H	Thyroid dyshormonogenesis 3 (TDH3)⁴ --	134192929(+)	`TGATAT/CGTAGC`	2	/R /C	mis¹ ese³		7		EA NS NA	644
rs2076739^1,2,,4	C	Thyroid dyshormonogenesis 3 (TDH3)⁴ pathogenic¹	134257890(+)	`TTGAAT/AGTGAA`	2	/S /C	mis¹		1		EA	220
VAR_063037⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063037	2	R Q	mis⁴		0	--	--	--	--
VAR_063035⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063035	2	C Y	mis⁴		0	--	--	--	--
VAR_063036⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063036	2	A D	mis⁴		0	--	--	--	--
VAR_063034⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063034	2	C Y	mis⁴		0	--	--	--	--
VAR_063038⁴		Thyroid dyshormonogenesis 3 (TDH3)⁴	--	see VAR_063038	2	G R	mis⁴		0	--	--	--	--
rs121912648^1,2	C,F	pathogenic¹	134168695(+)	`GATTCC/TGATGT`	2	R *	stg¹		2		NA EU	5871
rs121912646^1,2	C	pathogenic¹	134209483(+)	`AGTATC/TGAGCC`	2	R *	stg¹		0	--	--	--	--
rs2069566^1,2,,4	C	pathogenic¹	134304022(+)	`GAGGCG/ACTTCC`	2	/H /R	mis¹ ese³		3		EA NA	20

HapMap Linkage Disequilibrium report for TG (133879203 - 134129203 bp, first 250kb of TG)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TG (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2622999	CNV	Insertion	19546169
nsv509279	CNV	Insertion	20534489
esv1530894	CNV	Insertion	17803354
nsv6403	CNV	Insertion	18451855
nsv6402	CNV	Insertion	18451855
nsv891456	CNV	Loss	21882294
nsv525105	CNV	Loss	19592680
esv33367	CNV	Loss	17666407
nsv465818	CNV	Loss	19166990
esv33561	CNV	Loss	17666407

Human Gene Mutation Database (HGMD): TG

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TG

DNA2.0 Custom Variant and Variant Library Synthesis for TG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 188450
OMIM disorders: 274700 608175
UniProtKB/Swiss-Prot: THYG_HUMAN, P01266

Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing

large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid

dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a

relatively high serum free triiodothyronine (T3) concentration with disproportionately low free

tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue

hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and

intellectual defects in some cases. Note=The disease is caused by mutations affecting the gene represented in

this entry

Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related

diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive

T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2

differentiation and activate B cells to produce antibodies against the TSH receptor, which stimulate the thyroid

and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the

thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.

Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

Selected diseases for TG (see all 125): About MalaCards

suppurative thyroiditis autoimmune thyroid disease 3 malignant struma ovarii endemic goiter

goiter struma ovarii nontoxic goiter thyroid dyshormonogenesis 3

laryngocele graves' disease rapsn-related congenital myasthenic syndrome hashimoto's encephalitis

thyroxine-binding globulin deficiency iodine hypothyroidism myxedema autoimmune thyroiditis

toxic diffuse goiter subacute thyroiditis non-herpetic acute limbic encephalitis nodular goiter

12 diseases from the University of Copenhagen DISEASES database for TG:

Thyroid cancer Autoimmune thyroiditis Goiter Hypothyroidism

Hyperthyroidism Thyrotoxicosis Subacute thyroiditis Carcinoma

Thyroid adenoma Adenoma Teratoma Suppurative thyroiditis

TG for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for TG gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma	95.4	414	17892441 (5), 18630997 (4), 19160311 (4), 11325833 (3), 18284635 (3), 18098308 (3), 15212646 (3), 8157713 (3), 19743952 (3), 9641890 (3), 9854590 (3), 9804398 (3), 17505148 (3), 15579752 (2), 15670185 (2), 1947763 (2), 14759077 (2), 10411121 (2), 8288703 (2), 16794517 (2), 18682151 (2), 17115345 (2), 2145560 (2), 17665659 (2), 16595825 (2), 15985472 (2), 9591591 (2), 1305063 (2), 2040337 (2), 16116831 (2), 15251954 (2), 12915653 (2), 11727628 (2), 11437410 (2), 10487692 (2), 15972576 (2), 15994745 (2), 11585858 (2), 10524571 (2), 1466156 (2), 18758416 (2), 17278897 (2), 15765025 (2), 9508203 (2), 1352334 (2), 20017617 (2), 8350939 (2), 16434461 (2), 15841300 (2), 15157556 (2), 10792347 (2), 9670628 (2), 19589101 (2), 17006838 (2), 16574765 (2), 17726546 (2), 1859419 (1), 8510876 (1), 7829158 (1), 7833657 (1), 7580263 (1), 10543413 (1), 10727001 (1), 18528186 (1), 17971424 (1), 18060877 (1), 17578824 (1), 17609408 (1), 17270168 (1), 17077133 (1), 17021427 (1), 16509525 (1), 8635854 (1), 8565221 (1), 7528064 (1), 8168197 (1), 1524008 (1), 1574029 (1), 1780240 (1), 20096208 (1), 17460457 (1), 17684621 (1), 17123341 (1), 16922467 (1), 15701340 (1), 15761510 (1), 15232654 (1), 14557460 (1), 14530610 (1), 12965943 (1), 14557483 (1), 11370541 (1), 10989968 (1), 10365673 (1), 10219505 (1), 8970514 (1), 8787961 (1), 7570041 (1), 15251584 (1) (see top 4)
thyroid cancer	95	436	17302864 (4), 14588101 (3), 16479246 (3), 18613899 (3), 19769825 (3), 11061512 (3), 16033735 (3), 17100547 (3), 12782763 (3), 19154731 (3), 17710020 (3), 10566646 (3), 11974529 (3), 12542917 (3), 12193302 (3), 1561118 (2), 18759693 (2), 19636213 (2), 9920363 (2), 14973426 (2), 8970514 (2), 7688705 (2), 18769305 (2), 18090216 (2), 16681439 (2), 15105893 (2), 11836297 (2), 11197983 (2), 15251954 (2), 12641624 (2), 18207685 (2), 18426828 (2), 18166820 (2), 17555505 (2), 17279579 (2), 15497927 (2), 15094441 (2), 12843145 (2), 10404792 (2), 2292657 (2), 20353278 (2), 15695326 (2), 15256244 (2), 19383064 (2), 17956163 (2), 16187918 (2), 15157556 (2), 14870781 (2), 12699436 (2), 11301345 (2), 1881285 (2), 17524307 (2), 15797967 (2), 18268520 (2), 18097251 (2), 10090308 (2), 1341479 (2), 8086348 (1), 7833657 (1), 15283689 (1), 15271884 (1), 15640776 (1), 17077133 (1), 14654967 (1), 14605601 (1), 12813190 (1), 12773129 (1), 12206749 (1), 12029550 (1), 11729387 (1), 11325833 (1), 8177601 (1), 1862697 (1), 2040337 (1), 19961815 (1), 19910901 (1), 19607742 (1), 19551443 (1), 19577460 (1), 18685889 (1), 19169488 (1), 15762184 (1), 15701340 (1), 15232654 (1), 15232708 (1), 15181134 (1), 14604064 (1), 14588100 (1), 12142399 (1), 11158054 (1), 15251584 (1), 8222585 (1), 2005446 (1), 2090795 (1), 1699752 (1), 19851169 (1), 19910900 (1), 16895961 (1), 15830368 (1) (see top 4)
autoimmune thyroid disease	92.8	143	10570317 (3), 15096179 (3), 2256432 (2), 14973426 (2), 8102254 (2), 7889607 (2), 11441999 (2), 16704751 (2), 19050049 (2), 10436985 (2), 18656705 (2), 2015711 (1), 8014070 (1), 8933281 (1), 10601957 (1), 10090312 (1), 11308045 (1), 11695307 (1), 1862697 (1), 1983329 (1), 2311297 (1), 16761373 (1), 15793184 (1), 15579800 (1), 15008998 (1), 11788684 (1), 10718822 (1), 7711504 (1), 8457287 (1), 18178059 (1), 7533775 (1), 8258649 (1), 1954313 (1), 1713250 (1), 2022716 (1), 18299471 (1), 8752947 (1), 8330876 (1), 8467565 (1), 1476872 (1), 2307728 (1), 19947439 (1), 19034705 (1), 15544618 (1), 14657345 (1), 20215770 (1), 19776016 (1), 12780685 (1), 11297604 (1), 11129117 (1), 10987206 (1), 1721014 (1), 19284442 (1), 17223970 (1), 16756470 (1), 11736644 (1), 10403182 (1), 9398743 (1), 1698387 (1), 2153531 (1), 11454506 (1), 9183516 (1), 7852506 (1), 16945360 (1), 12965943 (1), 12864796 (1), 10826964 (1), 9737357 (1), 8565220 (1), 7528064 (1), 1424209 (1), 14971052 (1), 16335671 (1), 17725430 (1), 18029466 (1), 1571480 (1), 8424429 (1), 9545109 (1) (see top 4)
hashimotos thyroiditis	90.5	101	2242608 (3), 2226281 (2), 10670755 (2), 7962336 (2), 8966023 (2), 2256432 (1), 7833663 (1), 7580263 (1), 1720958 (1), 10071095 (1), 11129113 (1), 10826964 (1), 7528064 (1), 7687977 (1), 17143095 (1), 16206515 (1), 14678262 (1), 12213909 (1), 10502541 (1), 8999299 (1), 7742656 (1), 8102254 (1), 1724912 (1), 19264867 (1), 17823263 (1), 12848961 (1), 10347809 (1), 9344706 (1), 10482377 (1), 10436985 (1), 9068951 (1), 7743674 (1), 18095494 (1), 17223970 (1), 16602033 (1), 16756470 (1), 7829613 (1), 20215770 (1), 10745983 (1), 9218533 (1), 8752947 (1), 7579533 (1), 1373164 (1), 20477052 (1), 12780685 (1), 10987206 (1), 8187321 (1), 1284333 (1), 1698387 (1), 19667753 (1), 19050049 (1), 18656705 (1), 16704751 (1), 9183516 (1), 8258649 (1), 8094394 (1), 1481387 (1), 1726441 (1), 2101432 (1), 2107049 (1), 12965943 (1), 12553558 (1), 10570317 (1), 7527743 (1), 8443962 (1), 1915118 (1), 10984889 (1), 14971052 (1), 18029466 (1) (see top 4)
graves disease	89.4	145	16646680 (3), 1724781 (2), 10984889 (2), 11092696 (2), 11454506 (2), 1688155 (2), 18762990 (2), 2166430 (2), 11751544 (2), 1978459 (2), 7743674 (2), 10876005 (2), 2256432 (1), 8104224 (1), 12444888 (1), 14971052 (1), 18029466 (1), 2242608 (1), 1705860 (1), 2080137 (1), 18482926 (1), 17198353 (1), 10999849 (1), 10570317 (1), 8966023 (1), 7527743 (1), 8443962 (1), 18656705 (1), 10229914 (1), 9183516 (1), 7742656 (1), 8102254 (1), 18755875 (1), 17823263 (1), 10347809 (1), 7516033 (1), 16440775 (1), 10745983 (1), 10483254 (1), 10690629 (1), 8752947 (1), 7911812 (1), 7910048 (1), 1373164 (1), 8020185 (1), 19474733 (1), 18385936 (1), 18379045 (1), 1683085 (1), 2096159 (1), 2360457 (1), 17223970 (1), 16602033 (1), 16756470 (1), 10824047 (1), 10482369 (1), 1689529 (1), 8364879 (1), 12780685 (1), 10987206 (1), 10946880 (1), 10436985 (1), 9754221 (1), 9329373 (1), 7608274 (1), 7829613 (1), 8101679 (1), 1284333 (1), 1698387 (1), 1696557 (1), 8258649 (1), 7688705 (1), 2107049 (1), 18243140 (1), 15600194 (1), 14657389 (1), 12965943 (1), 7528064 (1), 1974494 (1), 17243910 (1), 12667218 (1), 7988028 (1), 7833663 (1), 7487672 (1), 9849814 (1) (see top 4)
thyroid diseases	89.1	126	18243140 (4), 10984889 (3), 11228272 (3), 12022704 (3), 9508203 (3), 8388753 (2), 7539201 (2), 8957481 (2), 7528064 (2), 1752339 (2), 10229914 (2), 10483254 (2), 8722578 (2), 8058301 (2), 16936513 (2), 2256432 (1), 12444888 (1), 16772197 (1), 7527743 (1), 8697622 (1), 10999849 (1), 2318474 (1), 19939287 (1), 18787379 (1), 12553558 (1), 11438400 (1), 11272097 (1), 9868291 (1), 7994910 (1), 8157713 (1), 11148327 (1), 10987206 (1), 10403176 (1), 9068951 (1), 8548999 (1), 1619946 (1), 19079713 (1), 9398743 (1), 2092906 (1), 10745983 (1), 8124482 (1), 18019649 (1), 17785297 (1), 14696848 (1), 16704751 (1), 14981996 (1), 12782763 (1), 9284706 (1), 8543331 (1), 18052943 (1), 17506473 (1), 15203250 (1), 7749502 (1), 7829613 (1), 8306534 (1), 1284333 (1), 1385030 (1), 14633662 (1), 14669943 (1), 14557483 (1), 11519462 (1), 10940722 (1), 10433080 (1), 9411419 (1), 1951413 (1), 8966023 (1), 7549998 (1), 18029466 (1), 16042141 (1), 7569734 (1), 7833663 (1), 1867098 (1) (see top 4)
goiter	88.5	123	2129364 (4), 1851064 (4), 7549998 (3), 9588493 (2), 16218041 (2), 2000697 (2), 7711505 (2), 16187918 (2), 1318692 (2), 18598585 (2), 10235039 (2), 8981932 (2), 20093166 (2), 1752952 (2), 1397384 (2), 7793989 (2), 8616533 (1), 10025449 (1), 10523025 (1), 12899791 (1), 8325944 (1), 16405252 (1), 16444154 (1), 15913449 (1), 9398747 (1), 7628349 (1), 8050126 (1), 17532758 (1), 16187910 (1), 19554808 (1), 18187871 (1), 18075286 (1), 17977395 (1), 16405406 (1), 12915634 (1), 10907993 (1), 10821321 (1), 10776989 (1), 19762181 (1), 18565420 (1), 17338121 (1), 16335774 (1), 15572417 (1), 10426591 (1), 9790265 (1), 8777378 (1), 1915109 (1), 2361565 (1), 9760285 (1), 9514162 (1), 9464451 (1), 7604491 (1), 2302248 (1), 16704751 (1), 15807875 (1), 12864801 (1), 8196172 (1), 7951537 (1), 8325250 (1), 2116437 (1), 2375236 (1), 17911408 (1), 12685194 (1), 11378813 (1), 11128728 (1), 8626865 (1), 7742656 (1), 7988459 (1), 1688155 (1), 12762640 (1), 10404833 (1), 9707574 (1), 11873391 (1), 7839886 (1), 7920005 (1), 19194833 (1), 15531495 (1), 14524121 (1), 8661844 (1) (see top 4)
goiter congenital	88.5	55	10199792 (3), 14764776 (2), 8325944 (2), 15769978 (2), 1726786 (2), 9292947 (1), 1727828 (1), 1975692 (1), 8050126 (1), 9707574 (1), 16477365 (1), 12915634 (1), 8981932 (1), 8325250 (1), 10403182 (1), 7604491 (1), 2096156 (1), 20093166 (1), 16720658 (1), 1752952 (1), 19633549 (1), 9790265 (1), 8777378 (1), 1915109 (1), 20089614 (1), 19438905 (1), 16271015 (1), 17062458 (1), 15171721 (1), 1397384 (1), 7635972 (1), 16042141 (1), 9588493 (1) (see top 4)
hypothyroidism	88.4	117	9790265 (3), 15014299 (2), 8966023 (2), 17978827 (2), 16184253 (2), 8777378 (2), 20375239 (2), 18631008 (2), 15769978 (2), 9588493 (1), 11389291 (1), 15387978 (1), 16296342 (1), 19337173 (1), 2258580 (1), 15687823 (1), 16405252 (1), 15761510 (1), 15243406 (1), 14763906 (1), 14565053 (1), 12542401 (1), 11041454 (1), 9881901 (1), 16187910 (1), 15604941 (1), 15751925 (1), 19509106 (1), 17823263 (1), 16394083 (1), 10404833 (1), 9707574 (1), 8837335 (1), 7883851 (1), 8325250 (1), 2149997 (1), 18945587 (1), 18095494 (1), 16543988 (1), 15350757 (1), 11729583 (1), 8936677 (1), 8778159 (1), 18363882 (1), 17060029 (1), 16676403 (1), 15572417 (1), 7621572 (1), 7695146 (1), 8263143 (1), 20089614 (1), 19438905 (1), 19762181 (1), 19554808 (1), 18332849 (1), 18075286 (1), 16628280 (1), 12915634 (1), 11257722 (1), 9198970 (1), 8196172 (1), 1726786 (1), 1696557 (1), 20093166 (1), 17956163 (1), 17053394 (1), 16704751 (1), 16261894 (1), 15689747 (1), 7868803 (1), 8327640 (1), 8094394 (1), 1472644 (1), 1348235 (1), 1987438 (1), 19910900 (1), 19265500 (1), 8733874 (1), 1727828 (1), 2254721 (1), 16806791 (1), 15670185 (1), 11874417 (1), 14764776 (1) (see top 4)
thyroid papillary carcinoma	87.6	64	15579752 (2), 1305063 (2), 16033735 (2), 16201895 (2), 10718554 (2), 11745281 (2), 12641624 (2), 17645579 (2), 7539201 (1), 18029466 (1), 10999849 (1), 11303631 (1), 16550594 (1), 20080852 (1), 14513322 (1), 10074219 (1), 8478715 (1), 16940367 (1), 16571089 (1), 16091757 (1), 10420227 (1), 1297527 (1), 20463837 (1), 11967907 (1), 10946899 (1), 10754474 (1), 11304850 (1), 20518406 (1), 15829073 (1), 15671775 (1), 18710471 (1), 11064390 (1), 11325833 (1), 12819023 (1), 14605601 (1), 18636294 (1), 20096208 (1) (see top 4)

Genatlas disease: TG

goiter associated to hypothyroidism and variant type of adenomatous goiter

Genetic Association Database (GAD): TG
Human Genome Epidemiology (HuGE) Navigator: TG (885 documents)

Export disorders for TG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TG gene, integrated from 10 sources (see all 1766):
(articles sorted by number of sources associating them with TG)

Utopia: connect your pdf to the dynamic
world of online information

The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PubMed id 19509106)^{1, 2, 9} Pardo V.... Medeiros-Neto G. (J. Clin. Endocrinol. Metab. 2009)
Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PubMed id 10199792)^{1, 2, 9} Hishinuma A.... Ieiri T. (J. Clin. Endocrinol. Metab. 1999)
Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent- exposed regions of the primary structure. (PubMed id 8269951)^{1, 2, 9} Gentile F. and Salvatore G. (Eur. J. Biochem. 1993)
A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PubMed id 16477365)^{1, 2, 9} Kitanaka S....Igarashi T. (J. Hum. Genet. 2006)
Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. (PubMed id 8797845)^{1, 2, 9} Molina F.... Granier C. (Eur. J. Biochem. 1996)
Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. (PubMed id 7793989)^{1, 2, 9} Xiao S.... Rawitch A.B. (Arch. Biochem. Biophys. 1995)
Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes. (PubMed id 20215770)^{1, 4, 9} Kotnik P....Battelino T. (Horm Res Paediatr 2010)
Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. (PubMed id 19034705)^{1, 4, 9} Maierhaba M....Dong B.N. (Endocrine 2008)
Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. (PubMed id 18385936)^{1, 4, 9} Hsiao J.Y....Ke D.S. (Clin. Exp. Med. 2008)
Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. (PubMed id 18755875)^{1, 4, 9} Hsiao J.Y....Ke D.S. (Eur. J. Endocrinol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7038	HGNC: 11764	AceView: TG	Ensembl:ENSG00000042832	euGenes: HUgn7038
ECgene: TG	Kegg: 7038	H-InvDB: TG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TG	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Thyroglobulin

Intellectual Property for TG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TG gene:
Search GeneIP for patents involving TG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TG gene at Home site.

Version: 3.12.136 22 July 2014
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TG Gene

Thyroglobulin

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recurrent cancer
stable disease
Pregnancy loss
Toxic diffuse goiter
Genetic Susceptibility
Acquired hypothyroidism
THYROID CARCINOMA ANAPLASTIC
PAPILLARY THYROID MICROCARCINOMA
Residual Cancer
Urticaria chronic
THYROID FOLLICULAR CARCINOMA
Thyroid Nodule
lung metastases
THYROID HORMONE RESISTANCE
Carcinoma Papillary Follicular
Turners Syndrome
Thyroid-Associated Ophthalmopathy
THYROID ECTOPIC
Hyperthyroidism
HYPOTHYROIDISM PRIMARY
primary tumor
GOITER CONGENITAL
THYROID CARCINOMA MEDULLARY
Cancer
Diabetes Mellitus Insulin-Dependent
multinodular goiter
GOITER COLLOID
THYROGLOBULIN SYNTHESIS DEFECT
Anemia Pernicious
follicular thyroid cancer
toxic adenoma
Congenital hypothyroidism
recurrent thyroid cancer
Thyroid Neoplasms
Nontoxic multinodular goiter
cancer recurrence
Iodine deficiency
THYROID CARCINOMA, HURTHLE CELL
Tumors
THYROID CYST
Metastasis
Autoimmunity
Celiac Disease
Thyroid dysfunction postpartum
TBG, SERUM
Thyroiditis
Ovarian Neoplasms
Endemic goiter
Autoimmune Diseases
Thyroid Storm
Adenoma Follicular
THYROTOXICOSIS FACTITIA
Goiter Nodular
Multiple Endocrine Neoplasia
Carcinoma Mucoepidermoid
GOITER TOXIC NODULAR
Carcinoma
Hypothyroidism
Addisons Disease
Thyroid Cancer
METASTATIC CARCINOMA
metastatic cancer
Carcinoma Papillary
Carcinoid
Carcinoma Anaplastic
THYROID PAPILLARY CARCINOMA
Goiter
Paraganglioma
Nontoxic goiter
Thyroiditis Subacute
THYROID ADENOMA
Adenoma Trabecular
Carcinoma Undifferentiated
GOITER ADENOMATOUS
diffuse goiter
Adenoma
Carcinoma Medullary
Thyroid Diseases
autoimmune thyroid disease
Struma Ovarii
Histopathology
papillary thyroid cancer
GOITER EUTHYROID
TSH DEFICIENCY
Autoimmune Response
Graves Disease
DYSFUNCTION THYROID
PENDRED SYNDROME
residual disease
Thyroiditis Chronic
Hashimotos Thyroiditis
THYROID CARCINOMA
Myxedema
bone metastases
CERVICAL CYST

GeneCards Plus

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Export list of displayed genes

TG Gene

Thyroglobulin

Aliasesfor TG gene

Summariesfor TG gene

Genomic Viewsfor TG gene

Proteinsfor TG gene

TG Human Recombinant Protein Products:

TG Antibody Products:

TG Assay Products:

Domains /Familiesfor TG gene

Functionfor TG gene

Localizationfor TG gene

Pathways & Interactionsfor TG gene

Drugs & Compoundsfor TG gene

Transcriptsfor TG gene

Expression for TG gene

Orthologsfor TG gene

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Genomic Variantsfor TG gene

Disorders / Diseasesfor TG gene

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Genome Databases showing TG gene

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for TG gene

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for TG gene

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for TG gene

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for TG gene

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