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TG Gene

protein-coding   GIFtS: 59
GCID: GC08P133879

Thyroglobulin

  See TG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
thyroglobulin1 2
AITD32 5
TGN2
Tg3
TDH35

External Ids:    HGNC: 117641   Entrez Gene: 70382   Ensembl: ENSG000000428327   OMIM: 1884505   UniProtKB: P012663   

Export aliases for TG gene to outside databases

Previous GC identifers: GC08P132608 GC08P133966 GC08P133550 GC08P133835 GC08P133948 GC08P129197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TG Gene:
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a
substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of
thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination,
and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid
dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism.
Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as
Graves disease and Hashimoto thryoiditis. (provided by RefSeq, Nov 2009)

GeneCards Summary for TG Gene:
TG (thyroglobulin) is a protein-coding gene. Diseases associated with TG include goiter, and endemic goiter. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Gene Wiki entry for TG (Thyroglobulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TG gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   COUP-TF   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TG promoter sequence
   Search Chromatin IP Primers for TG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

TG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TG gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P133879:  view genomic region     (about GC identifiers)

Start:
133,879,203 bp from pter      End:
134,147,147 bp from pter
Size:
267,945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THYG_HUMAN, P01266 (See protein sequence)
Recommended Name: Thyroglobulin precursor  
Size: 2768 amino acids; 304790 Da
Subunit: Homodimer
Secondary accessions: O15274 O43899 Q15593 Q15948 Q9NYR1 Q9NYR2 Q9UMZ0 Q9UNY3
Alternative splicing: 2 isoforms:  P01266-1   P01266-2   

Explore the universe of human proteins at neXtProt for TG: NX_P01266

Explore proteomics data for TG at MOPED

Post-translational modifications: 

  • Sulfated tyrosines are desulfated during iodination1
  • Glycosylation2 at Asn76, Asn198, Asn484, Asn529, Asn748, Asn816, Asn947, Asn1220, Asn1348, Asn1349,
                                 Asn1365, Asn1716, Asn1774, Asn2013, Asn2250, Asn2295, Asn2582, Ser2749
  • Modification sites at PhosphoSitePlus

  • See TG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003226.4  
    ENSEMBL proteins: 
     ENSP00000427871   ENSP00000220616   ENSP00000428628   ENSP00000429605   ENSP00000430523  
     ENSP00000429164   ENSP00000430430   ENSP00000430087   ENSP00000429761   ENSP00000430161  
     ENSP00000367100   ENSP00000441693  

    TG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for TG
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TG
    GenScript Custom Purified and Recombinant Proteins Services for TG
    Novus Biologicals TG Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TG
    Cloud-Clone Corp. Proteins for TG

     
    Search eBioscience for Proteins for TG 

    TG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TG Antibodies
    Abcam antibodies for TG
    Cloud-Clone Corp. Antibodies for TG
    ThermoFisher Antibody for TG
    LSBio Antibodies in human, mouse, rat for TG

    TG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TG
    Cloud-Clone Corp. CLIAs for TG
    Search eBioscience for ELISAs for TG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
     IPR000716 Thyroglobulin_1
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB
     IPR016324 Thyroglobulin

    Graphical View of Domain Structure for InterPro Entry P01266

    ProtoNet protein and cluster: P01266

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Similarity: Belongs to the type-B carboxylesterase/lipase family
    Similarity: Contains 11 thyroglobulin type-1 domains


    Find genes that share domains with TG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THYG_HUMAN, P01266
    Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

         Genatlas biochemistry entry for TG:
    thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872NOT receptor activity IRD--
    GO:0005179hormone activity IEA--
    GO:0042043NOT neurexin family protein binding IRD--
         
    Find genes that share ontologies with TG           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tg):
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with TG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TG

    miRNA
    Products:
        
    miRTarBase miRNAs that target TG:
    hsa-let-7f-5p (MIRT032091)

    Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TG
    Predesigned siRNA for gene silencing in human, mouse, rat TG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TG

    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for TG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TG
    Browse ESI BIO Cell Lines and PureStem Progenitors for TG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11466 VA6-13133) for TG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THYG_HUMAN, P01266: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum3
    plasma membrane3
    cytoskeleton2
    golgi apparatus2
    lysosome2
    mitochondrion2
    nucleus2
    vacuole2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IBA--
    GO:0005887NOT integral component of plasma membrane IRD--
    GO:0009986NOT cell surface IRD--
    GO:0045202NOT synapse IRD--

    Find genes that share ontologies with TG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TG About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Autoimmune thyroid disease0.61
    2Insulin secretion
    Thyroid hormone synthesis0.36
    3Thyroxine (Thyroid Hormone) Production
    Thyroxine (Thyroid Hormone) Production


    Find genes that share SuperPaths with TG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TG
        Thyroxine (Thyroid Hormone) Production


    2 Kegg Pathways  (Kegg details for TG):
        Thyroid hormone synthesis
    Autoimmune thyroid disease

        Pathway & Disease-focused RT2 Profiler PCR Array including TG: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TG (P012663 ENSP000002206164) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110213, ENSP000003241734I2D: score=4 STRING: ENSP00000324173
    ASGR1P073063, ENSP000002692994I2D: score=1 STRING: ENSP00000269299
    CTSDP073393, ENSP000002366714I2D: score=1 STRING: ENSP00000236671
    APCSP027433, ENSP000002550404I2D: score=1 STRING: ENSP00000255040
    CANXP278243, ENSP000002474614I2D: score=1 STRING: ENSP00000247461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation IBA--
    GO:0007165signal transduction NAS3016640
    GO:0007416NOT synapse assembly IRD--
    GO:0015705iodide transport IEA--
    GO:0030878thyroid gland development IEP15494458

    Find genes that share ontologies with TG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TG (THYG)

    Selected Novoseek inferred chemical compound relationships for TG gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iodine 91.3 525 1954313 (7), 9292948 (6), 12713257 (4), 19160311 (4) (see all 99)
    thyroxine 90.9 582 1466156 (7), 10229914 (6), 11694378 (4), 8890722 (4) (see all 99)
    iodide 83.8 155 10537174 (6), 16648292 (4), 19951699 (3), 20364596 (3) (see all 73)
    triiodothyronine 83.3 331 11288978 (4), 11694378 (4), 10822292 (4), 16477365 (3) (see all 99)
    sodium iodide 78.5 31 19050049 (2), 10090312 (1), 17199440 (1), 18430446 (1) (see all 21)
    diiodotyrosine 77.4 15 8900403 (3), 1954313 (1), 8651700 (1), 9717982 (1) (see all 7)
    iodotyrosine 73.2 15 15289438 (2), 1727828 (1), 9737985 (1), 1281126 (1) (see all 9)
    methimazole 69.9 8 14657389 (1), 1794603 (1), 1688155 (1), 8075781 (1) (see all 5)
    thyronine 66.5 6 9434803 (1), 9717982 (1), 9344702 (1), 9419438 (1)
    18f fluorodeoxyglucose 60.9 40 12186505 (4), 19910903 (2), 10452315 (2), 12656659 (2) (see all 19)



    Find genes that share compounds with TG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TG gene: 
    NM_003235.4  

    Unigene Cluster for TG:

    Thyroglobulin
    Hs.654591  [show with all ESTs]
    Unigene Representative Sequence: NM_003235
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000523901 ENST00000220616(uc003ytw.3 uc010mdw.3) ENST00000520769
    ENST00000523756(uc011ljb.2) ENST00000518097 ENST00000518505 ENST00000519178
    ENST00000518058 ENST00000519543(uc011ljc.2) ENST00000520197 ENST00000520089
    ENST00000519294 ENST00000524151 ENST00000522523 ENST00000522797 ENST00000518108
    ENST00000522996 ENST00000522809
    miRNA
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    Block miRNA regulation of human, mouse, rat TG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TG
    Predesigned siRNA for gene silencing in human, mouse, rat TG
    Clone
    Products:
         
    OriGene clones in human, mouse for TG (see all 5)
    OriGene ORF clones in mouse, rat for TG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TG
      QuantiTect SYBR Green Assays in human, mouse, rat TG
      QuantiFast Probe-based Assays in human, mouse, rat TG
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11466 VA6-13133) for TG 

    Additional mRNA sequence: 

    AB209159.1 AK299197.1 AK303666.1 AK303667.1 BC127887.1 BC140933.1 S40807.1 S80793.1 
    X02154.1 X05615.1 

    Selected DOTS entries (see all 80):

    DT.95202433  DT.95177266  DT.95219259  DT.91713338  DT.100826698  DT.100826700  DT.452683  DT.92472293 
    DT.120642240  DT.95333374  DT.120642266  DT.100826697  DT.100826709  DT.100826704  DT.120642467  DT.100826710 
    DT.120642305  DT.120642340  DT.91698313  DT.95333484  DT.100829949  DT.92472287  DT.95333469  DT.95246308 

    1041 AceView cDNA sequences (see top 24):

    AU141761 AA384674 AU141693 AU142018 AU141921 AU141623 AU141456 AU141850 
    AU141264 AU141642 AA384456 BE168159 AU141713 AU141584 AA385241 AU141981 
    AU141691 AU141975 AA385060 AU142003 AU141892 AU141459 AU141307 AU141980 
    AU142057 AU141479 AU141390 AU141182 AU141633 AU142041 AU142061 BQ355719 
    AU142002 AU142169 BE168393 AU159100 AU141806 AU141303 AU141210 AU142145 
    BE175812 AU141572 AU141607 AU141967 AA385031 AU141774 AU142107 AU141589 
    AU141760 AU141594 AU141158 AU142088 AU141152 AU142136 AU159231 BE169827 
    AU141146 AU159397 AA384524 AU141413 AU141176 AU141224 AU141683 AU141790 
    AU141815 AU141473 AU141168 AU141754 AU142091 AU141692 AU141219 AU141288 
    AU159481 AU141418 AU141653 AU142017 AA384835 AU141984 AU141992 AU141431 
    AU141858 BE931984 AU141123 AU141558 AU141782 AU141974 AU142006 AU141359 
    AU141574 AU142139 AU141684 AU141842 AU141628 AU141920 AU142020 AU141198 
    AU141706 AU141578 AU141588 AU141888 BG995001 AU141258 AU141376 AU141568 
    BF844297 AU141214 AU141357 AU141932 BG948896 AU142062 AU141375 AU141958 
    AU141800 AU141091 AU141250 AU141247 AU159072 AU141191 AU141553 AU141709 
    AU141411 AU142170 AU141545 AU141809 AU141631 AU141991 BE168388 AU142187 
    S40807 AU142024 AU142075 AU142149 AU142025 AU141116 AU141453 AU141829 
    AU141299 AU141420 AU141923 AU141986 AU141734 BF841986 BE168382 AA385571 
    AU141492 AU141964 AU141877 AU142166 AU159103 AU142105 AU141775 AU142152 
    AU141289 AU141771 AU141143 AU142050 BE168236 AU141680 AU141748 AU141641 
    AU141904 AU159354 AU142090 AU141859 AU142069 AU142021 AU141644 AU141229 
    AA384653 AU141240 AA385672 AA384903 AU141777 AU141941 AU142111 AU141788 
    AU141213 AU141155 AU142056 AU141831 AU141519 AU158954 BG178398 AU141368 
    BI002777 AU141647 AU141172 AU141188 AU141719 BE168391 AU141511 AU141206 
    AU141350 AU141993 AU141772 AA385264 AA385311 AU141792 AU141999 AU141902 
    AU141269 AU141924 AU141955 BI000239 AU141366 AU141571 AI686243 AU141714 
    AU141204 AU141222 AU158898 AU141717 AA384424 AU142013 AU141144 AU141763 
    AU142009 AU141802 AU142167 AU141956 AU141466 AU141959 AU141451 AU141412 
    AU142144 AU142019 AU141606 AU141287 AU141461 AU141443 AU142142 AU141513 
    AU141387 AU141655 AU158816 BX484701 AU142183 AU141544 AU142133 AA384923 
    AU159208 BV190838 AU141551 AA384545 AU141323 AU141489 AU141408 AU142046 
    AU141918 AW135731 BF839930 AU141592 AU141846 BX485604 AU141525 BE168402 
    X05615 BE163464 AU141712 AU141100 AU141867 NM_003235 BE810814 AU141970 
    AU141758 BX484514 AU141654 AU141540 BE044620 AA385159 AU141835 AU141399 
    AU141263 AU141853 AU141873 AU141582 BF841435 AU141313 AU142026 AU141108 
    AU141233 AU141127 AU141555 AU141260 AU141848 BG999814 AU142188 AU141470 
    AU141445 BF087299 AU141995 AA385219 AU141922 BF841436 BG998994 AU141290 
    AU141122 AA384919 AU141880 AU141839 AU141162 AA384481 AU141101 AU141830 
    AU141235 AA384549 AU141102 AU141976 AA385165 BI005872 AA295658 AW874093 
    AU141189 AU141599 BF741157 AU159411 AU141237 AU141851 BG999877 AU141834 
    AU158967 BQ359843 AU141878 AU141903 AU141600 AU142135 AU159010 AU158872 
    AU141341 AL039612 AA385746 AU141926 AU142143 AU159487 AI420099 AU142151 
    AU141246 AU141455 AU141117 AU141333 AU159356 AU158856 AU141097 AU159207 
    AU142119 BV205066 AU142164 AU141107 AU158831 AA384059 AA868565 AU159298 
    AU141735 BI765505 AU141440 AU141838 AU141154 AU141783 AA384391 BX506769 
    AU141192 AU141251 BI004394 U93033 AA384938 AU141136 AU158918 AU159012 
    AU141381 AA385215 AU141361 BE163041 AU141884 AU159220 AL039611 AU142054 
    AU141890 AU141409 AU142141 AU142001 AU141343 AU141565 AU141743 AA384349 
    AU159453 AU141139 AU158925 AU141135 BE931909 AU141733 AU141598 AU142126 
    AU141778 AU142130 AU141450 AU141485 BE168168 AU142012 AA384822 AU141737 
    AA384094 AU141510 BG993242 AU159499 BU680131 AU141621 AA384688 AU141810 
    BQ301274 BG284464 AU141395 AU141503 BG187148 AU158920 AU141215 AU141768 
    AU159511 AU142096 AA384409 BQ359811 BE931901 AU141585 AU141836 AA384841 
    BE168389 AU141596 AU141566 BE810811 AU141197 AU141674 BE707499 AU141114 
    AU142071 AU141860 AU141227 AU141410 AU141340 AA295587 AU141560 AU159015 
    AU159277 BE161450 AU159107 AU141557 AU141930 AW873976 AW505008 AU141536 
    AU141508 AU141153 BE164958 AU141259 CB986780 AU141580 X02154 AU141799 
    AU141502 AU141786 AA384400 AU141668 AU142127 BG998814 AU141617 AU141331 
    BF841923 BF829383 BX484963 AU159375 AU159191 BE163052 AA384298 AU159241 
    AA385178 BG998588 AU159000 AU159353 BF741811 AU159139 AU159119 AU159271 
    BE163309 AU159202 BE046139 AA385472 AU159245 BQ355712 BE170507 BQ349693 
    BG998990 CB958855 BF351279 BG948948 BG997301 AU159399 BF829865 BQ355684 
    BE707398 AU159334 BE180756 AU142116 BG948941 AW874044 AA383764 BF351457 
    AU158955 BG998816 CB987431 AA384597 BE168170 AU158985 BE161452 AU159309 
    BE169584 BG180901 AU159250 CB986174 BE044632 AU159013 BE707406 BE045832 
    BG990923 AW874163 AA493254 BE163048 AW874015 BE168380 AU158853 BG998825 
    AA385340 BQ355699 BG992572 AU159407 AU158786 AA384397 AA384009 BQ350239 
    AU159246 BI001931 BF841500 AA632990 BQ355215 BG997167 BG949146 AU159256 
    AU158986 BE168387 AW780039 BG997815 BF741096 AA493892 BI002682 AU159255 
    BG999822 BG998817 BE168385 AU158994 AU159055 BG948992 AA384233 BE168379 
    BI005485 BE168028 AW874106 BE045803 BI005725 AU141115 AA632843 BF842113 
    AU159358 BE163024 BF741106 AA384340 BI003880 AU159096 BF351670 BQ355598 
    BQ355499 BE168232 AA385492 CB959392 AU158958 AU159251 AU158984 AU158797 
    AW873205 AU159469 AU159249 AU159223 BF841434 AU159178 BE710030 BQ354982 
    BI004669 AW874184 AU158792 AU158775 BF741863 AU159193 AU158837 BE164858 
    BF741404 BE168384 BE045197 AW772580 AU159506 BG999503 AU159424 AA385405 
    AU159027 BG998997 AU158935 AU159024 AU158858 AU159308 AU159315 AU159136 
    AU159088 AU159291 BF828051 AU158939 AU159377 BE839782 AU159003 BG991003 
    AU159011 AW872522 BE045301 BF841380 BG997305 AU158993 AU159060 AU159161 
    AU158765 AU159051 BG998472 AU159259 AU159497 BG999736 AU158845 BE707381 
    AU159295 BE163057 BG996444 BF842104 AU159017 AU159240 AU158926 BE707387 
    AU159310 BI005288 AU159043 BE044612 BI005065 AA632570 AU159221 AU141751 
    BI003403 BQ301622 BG988555 BI005062 BE168392 AU159483 AU159326 BF741865 
    AU159364 AW873962 BE164901 BE163046 AU159468 BI825164 BG990585 AU159297 
    AU159182 AU158849 BE168166 CB986845 BG998902 BF352337 BI004406 AU159054 
    AU158841 BQ355583 AU159505 AU159192 BF828283 AU158828 BF841679 AU158911 
    BI004478 AU158844 BE168390 BF839204 AU159372 BF740325 AU159160 AW874102 
    AU159020 AU159509 AU158766 BF740320 BF839304 AU159049 AU141989 AU159210 
    AU159501 AU159520 AU159056 AU159517 AU159452 AU159115 BF828054 AU158981 
    BF841317 BG990933 AU158771 AU158788 AU158800 BE707384 AU159234 AU158963 
    AU158824 AU159531 AU159237 AW874192 AU158851 AU159290 BG999518 AU159307 
    BF737686 BE707470 AU158827 AU159244 BQ301333 AU159413 BE161920 BE168452 
    AU159005 AU158974 BI004407 AU159379 AU158889 BF838149 AU158870 AU158813 
    AU159086 AW873383 AA385689 AW293728 BI004569 AW874098 AU159490 BI000001 
    AU159403 BF741111 AU159098 BF837422 BQ354849 BQ359892 AA384604 BQ354808 
    BE168164 AU158938 AU159084 BF842795 BG999591 BI005737 AU159458 BG992397 
    AU159031 BE707442 BI004018 BF841630 AU159112 BE044881 BE046055 AU159121 
    BE163045 AU159518 BE707443 BI004161 AU159428 AU159418 AU158819 BF841419 
    AU159079 AU158774 AU159521 AU158770 BF842047 AU159419 CD616643 AA493234 
    AU159205 AU159454 BE159501 BG990601 BF829040 AU159117 AA494222 BF841326 
    AW874185 AU159171 AU159078 AU159252 BQ352195 AA385458 BI004110 AU159423 
    AU158838 BI003311 BF828285 BE044805 BI000511 AA385316 AW780037 BQ359533 
    AU159416 AA384279 AU158948 BF841481 BI004838 T29891 AU159305 AU159159 
    BF839199 AU159181 AU158811 BI003650 AU159110 BF828446 AU159064 AA385655 
    AU159400 BF839938 BG948883 BF841758 BF829933 BE168034 AU159144 AU159384 
    AU158950 AU158990 BG948996 AU159041 AU159427 AU159101 BI004208 BF828432 
    AU158980 AU159425 AA384458 BE164856 AU158778 AU159138 BG995062 BI000515 
    AU159300 BE177529 BI002690 BF838112 BG998474 BE163039 AU159292 BF829038 
    AA618133 AU159327 AU158781 BE180754 AU158799 AU159227 BE164899 AU159294 
    AW959060 BF841374 BQ359836 BF839299 AA385295 BE163091 AU159410 BE708288 
    AU158804 BG999915 AU159394 BF828971 BQ301493 AU159496 BF839932 AA618136 
    BF740301 BF841417 BE707360 BG994951 AU159333 BQ301341 BG991296 BE163067 
    BQ359537 BE170273 BF841755 AU158876 AU158971 AU159114 AU158863 AU158791 
    BF740435 BE708582 BF843208 BF828431 BF844969 BG999920 AU159075 AU159343 
    AU159089 BE162859 AW873414 AW874159 BF829298 BG999165 BF828335 AU159512 
    BI002683 BI002776 BF828968 AU159314 AU159392 BI000092 AU159528 BE162862 
    AU159151 AU159106 BI003098 BF828332 BF844196 BF741509 BF741158 AU159388 
    BF828904 BF828041 AU159260 BI000513 BQ349608 BG999410 AU159516 BF841329 
    AU158866 BF841316 BI000505 BF845311 BF827110 AU159385 BI002768 AU158798 
    BG991458 BF828445 BF740312 AU159448 BI005490 AU159442 BF828333 BF829921 
    BE162860 BE168386 BQ301335 BE162854 BI003309 BQ301620 BG999910 BQ359758 
    BF829366 BF829293 AW874088 BI004212 AU159128 BF828290 BG999926 BE168728 
    BI003983 BI004809 BF828969 BE163303 BG994899 BQ354759 BF837418 BG948885 
    BF829017 BF740715 BG999556 BG999741 AU158983 BF740716 BE163319 BF828906 
    BF829936 BG995989 BE163225 BF842022 BQ301479 AI214881 BF839943 BE163259 
    BG998519 BI004106 AU159153 BF829384 AU159083 BE168060 BI003326 BG997302 
    BG998810 BI005447 BI002988 BF844505 BF841424 BF844295 BF841927 BG999720 
    BE163089 BF740418 AA493563 AW874198 BG988567 BE167394 BI001280 BG999726 
    BE168031 BF828900 BG949144 BQ301207 CB958771 BG985041 BF841363 AU159409 
    AU158888 BG999739 AW874215 BG999922 BG992356 BF741846 BE708540 BQ350447 
    BF841497 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TG Expression
    About this image


    TG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thyroid (Endocrine System)
             Thyroid Progenitors
     
     Gut Tube (Gastrointestinal Tract)
             Anterior foregut progenitor cells
     
     Lung (Respiratory System)
             Immature proximal lung cells
     
     Larynx (Respiratory System)
    TG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654591

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Tissue specificity: Thyroid gland specific

        Pathway & Disease-focused RT2 Profiler PCR Array including TG: 
              Insulin Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TG
    QuantiTect SYBR Green Assays in human, mouse, rat TG
    QuantiFast Probe-based Assays in human, mouse, rat TG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for TG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tg1 , 5 thyroglobulin1, 5 78.6(n)1
    74.35(a)1
      15 (29.30 cM)5
    218191  NM_009375.21  NP_033401.21 
     666707535 
    chicken
    (Gallus gallus)
    Aves TG1 thyroglobulin 61.3(n)
    55.62(a)
      100857838  XM_003640868.2  XP_003640916.2 
    lizard
    (Anolis carolinensis)
    Reptilia TG6
    thyroglobulin
    53(a)
    1 ↔ 1
    4(662513-807612)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tg1 thyroglobulin 55.55(n)
    48.51(a)
      100492021  XM_002939515.2  XP_002939561.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tg1 thyroglobulin 52.54(n)
    44.44(a)
      567631  XM_689200.5  XP_694292.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Est86
    alpha-Esterase-8
    18(a)
    1 → many
    3R(3335065-3341391)
    worm
    (Caenorhabditis elegans)
    Secernentea Y75B8A.36
    Protein Y75B8A.3 (Y75B8A.3) mRNA, complete cds
    12(a)
    1 ↔ 1
    III(12101745-12106535) WBGene00013540


    ENSEMBL Gene Tree for TG (if available)
    TreeFam Gene Tree for TG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TG gene
    9 SIMAP similar genes for TG using alignment to 13 protein entries:     THYG_HUMAN (see all proteins):
    NLGN2    CES2    CES3    CES5A    NLGN3    DKFZp686F02202
    ACHE    BCHE    CES1P1

    Find genes that share paralogs with TG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TG (see all 6587)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20767381,2,,4
    C,HThyroid dyshormonogenesis 3 (TDH3)4 --134192929(+) TGATAT/CGTAGC 2 /R /C mis1 ese37Minor allele frequency- C:0.00EA NS NA 644
    rs20767391,2,,4
    CThyroid dyshormonogenesis 3 (TDH3)4 pathogenic1134257890(+) TTGAAT/AGTGAA 2 /S /C mis11Minor allele frequency- A:0.00EA 220
    VAR_0630374
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630372 R Q mis40--------
    VAR_0630354
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630352 C Y mis40--------
    VAR_0630364
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630362 A D mis40--------
    VAR_0630344
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630342 C Y mis40--------
    VAR_0630384
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630382 G R mis40--------
    rs1219126481,2
    C,Fpathogenic1134168695(+) GATTCC/TGATGT 2 R * stg12Minor allele frequency- T:0.00NA EU 5871
    rs1219126461,2
    Cpathogenic1134209483(+) AGTATC/TGAGCC 2 R * stg10--------
    rs20695661,2,,4
    Cpathogenic1134304022(+) GAGGCG/ACTTCC 2 /H /R mis1 ese33Minor allele frequency- A:0.00EA NA 20

    HapMap Linkage Disequilibrium report for TG (133879203 - 134129203 bp, first 250kb of TG)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TG (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2622999CNV Insertion19546169
    nsv509279CNV Insertion20534489
    esv1530894CNV Insertion17803354
    nsv6403CNV Insertion18451855
    nsv6402CNV Insertion18451855
    nsv891456CNV Loss21882294
    nsv525105CNV Loss19592680
    esv33367CNV Loss17666407
    nsv465818CNV Loss19166990
    esv33561CNV Loss17666407

    Human Gene Mutation Database (HGMD): TG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TG
    DNA2.0 Custom Variant and Variant Library Synthesis for TG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 188450   
    OMIM disorders: 274700  608175  
    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
  • Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing
    large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid
    dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a
    relatively high serum free triiodothyronine (T3) concentration with disproportionately low free
    tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue
    hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and
    intellectual defects in some cases. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related
    diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive
    T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2
    differentiation and activate B cells to produce antibodies against the TSH receptor, which stimulate the thyroid
    and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the
    thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for TG (see all 36):    
    About MalaCards
    goiter    endemic goiter    thyroid dyshormonogenesis 3    autoimmune thyroid disease 3
    laryngocele    malignant struma ovarii    struma ovarii    suppurative thyroiditis
    nontoxic goiter    hashimoto's encephalitis    hypothyroidism    toxic diffuse goiter
    subacute thyroiditis    non-herpetic acute limbic encephalitis    myxedema    graves' disease
    thyroiditis    thyrotoxicosis    multinodular goiter    limbic encephalitis

    12 diseases from the University of Copenhagen DISEASES database for TG:
    Thyroid cancer     Autoimmune thyroiditis     Goiter     Hypothyroidism
    Hyperthyroidism     Thyrotoxicosis     Subacute thyroiditis     Carcinoma
    Thyroid adenoma     Adenoma     Teratoma     Suppurative thyroiditis

    Find genes that share disorders with TG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 95.4 414 17892441 (5), 18630997 (4), 19160311 (4), 11325833 (3) (see all 99)
    thyroid cancer 95 436 17302864 (4), 14588101 (3), 16479246 (3), 18613899 (3) (see all 99)
    autoimmune thyroid disease 92.8 143 10570317 (3), 15096179 (3), 2256432 (2), 14973426 (2) (see all 78)
    hashimotos thyroiditis 90.5 101 2242608 (3), 2226281 (2), 10670755 (2), 7962336 (2) (see all 69)
    graves disease 89.4 145 16646680 (3), 1724781 (2), 10984889 (2), 11092696 (2) (see all 85)
    thyroid diseases 89.1 126 18243140 (4), 10984889 (3), 11228272 (3), 12022704 (3) (see all 72)
    goiter 88.5 123 2129364 (4), 1851064 (4), 7549998 (3), 9588493 (2) (see all 79)
    goiter congenital 88.5 55 10199792 (3), 14764776 (2), 8325944 (2), 15769978 (2) (see all 33)
    hypothyroidism 88.4 117 9790265 (3), 15014299 (2), 8966023 (2), 17978827 (2) (see all 84)
    thyroid papillary carcinoma 87.6 64 15579752 (2), 1305063 (2), 16033735 (2), 16201895 (2) (see all 37)

    Genatlas disease: TG
    goiter associated to hypothyroidism and variant type of adenomatous goiter

    Genetic Association Database (GAD): TG
    Human Genome Epidemiology (HuGE) Navigator: TG (885 documents)

    Export disorders for TG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TG gene, integrated from 10 sources (see all 1766):
    (articles sorted by number of sources associating them with TG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PubMed id 19509106)1, 2, 9 Pardo V.... Medeiros-Neto G. (J. Clin. Endocrinol. Metab. 2009)
    2. Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PubMed id 10199792)1, 2, 9 Hishinuma A.... Ieiri T. (J. Clin. Endocrinol. Metab. 1999)
    3. Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent- exposed regions of the primary structure. (PubMed id 8269951)1, 2, 9 Gentile F. and Salvatore G. (Eur. J. Biochem. 1993)
    4. A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PubMed id 16477365)1, 2, 9 Kitanaka S....Igarashi T. (J. Hum. Genet. 2006)
    5. Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. (PubMed id 8797845)1, 2, 9 Molina F.... Granier C. (Eur. J. Biochem. 1996)
    6. Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. (PubMed id 7793989)1, 2, 9 Xiao S.... Rawitch A.B. (Arch. Biochem. Biophys. 1995)
    7. Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes. (PubMed id 20215770)1, 4, 9 Kotnik P....Battelino T. (Horm Res Paediatr 2010)
    8. Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. (PubMed id 19034705)1, 4, 9 Maierhaba M....Dong B.N. (Endocrine 2008)
    9. Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. (PubMed id 18385936)1, 4, 9 Hsiao J.Y....Ke D.S. (Clin. Exp. Med. 2008)
    10. Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. (PubMed id 18755875)1, 4, 9 Hsiao J.Y....Ke D.S. (Eur. J. Endocrinol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7038 HGNC: 11764 AceView: TG Ensembl:ENSG00000042832 euGenes: HUgn7038
    ECgene: TG Kegg: 7038 H-InvDB: TG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TG Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Thyroglobulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TG gene:
    Search GeneIP for patents involving TG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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