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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TG Gene

protein-coding   GIFtS: 58
GCID: GC08P133879

Thyroglobulin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
thyroglobulin1 2
AITD32 5
TGN2
Tg3
TDH35

External Ids:    HGNC: 117641   Entrez Gene: 70382   Ensembl: ENSG000000428327   OMIM: 1884505   UniProtKB: P012663   

Export aliases for TG gene to outside databases

Previous GC identifers: GC08P132608 GC08P133966 GC08P133550 GC08P133835 GC08P133948 GC08P129197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TG Gene:
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a
substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of
thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination,
and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid
dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism.
Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as
Graves disease and Hashimoto thryoiditis. (provided by RefSeq, Nov 2009)

GeneCards Summary for TG Gene: 
TG (thyroglobulin) is a protein-coding gene. Diseases associated with TG include goiter, and struma ovarii, and among its related super-pathways are Allograft rejection and Insulin secretion. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

Gene Wiki entry for TG (Thyroglobulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TG gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   COUP-TF   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TG promoter sequence
   Search SABiosciences Chromatin IP Primers for TG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

TG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TG gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P133879:  view genomic region     (about GC identifiers)

Start:
133,879,203 bp from pter      End:
134,147,147 bp from pter
Size:
267,945 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THYG_HUMAN, P01266 (See protein sequence)
Recommended Name: Thyroglobulin precursor  
Size: 2768 amino acids; 304790 Da
Subunit: Homodimer
Subcellular location: Secreted
Secondary accessions: O15274 O43899 Q15593 Q15948 Q9NYR1 Q9NYR2 Q9UMZ0 Q9UNY3
Alternative splicing: 2 isoforms:  P01266-1   P01266-2   

Explore the universe of human proteins at neXtProt for TG: NX_P01266

Explore proteomics data for TG at MOPED 

Post-translational modifications:

  • UniProtKB: Sulfated tyrosines are desulfated during iodination
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01266

  • TG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TG Protein Expression
    REFSEQ proteins: NP_003226.4  
    ENSEMBL proteins: 
     ENSP00000427871   ENSP00000220616   ENSP00000428628   ENSP00000429605   ENSP00000430523  
     ENSP00000429164   ENSP00000430430   ENSP00000430087   ENSP00000429761   ENSP00000430161  
     ENSP00000367100   ENSP00000441693  

    Human Recombinant Protein Products for TG: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TG
    GenScript Custom Purified and Recombinant Proteins Services for TG
    Novus Biologicals TG Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TG
    Cloud-Clone Corp. Proteins for TG 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IBA--
    GO:0005887NOT integral to plasma membrane IRD--
    GO:0009986NOT cell surface IRD--
    GO:0045202NOT synapse IRD--

    TG for ontologies           About GeneDecksing



    TG Antibody Products: 
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    Abcam antibodies for TG
    Cloud-Clone Corp. Antibodies for TG 
    ThermoFisher Antibody for TG
    LSBio Antibodies in human, mouse, rat for TG 

    Assay Products for TG: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TG 
    Cloud-Clone Corp. CLIAs for TG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
     IPR000716 Thyroglobulin_1
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB
     IPR016324 Thyroglobulin

    Graphical View of Domain Structure for InterPro Entry P01266

    ProtoNet protein and cluster: P01266

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Similarity: Belongs to the type-B carboxylesterase/lipase family
    Similarity: Contains 11 thyroglobulin type-1 domains


    TG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THYG_HUMAN, P01266
    Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

         Genatlas biochemistry entry for TG:
    thyroglobulin,precursor of thyroid hormone,involved in storage of iodine and of inactive thyroid hormones

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091NOT carboxylesterase activity IKR--
    GO:0004872NOT receptor activity IRD--
    GO:0005179hormone activity IEA--
    GO:0042043NOT neurexin family protein binding IRD--
         
    TG for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tg):
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  nervous system 

    TG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TG


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TG (see all 5)
    OriGene ORF clones in mouse, rat for TG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TG
    Search LifeMap BioReagents cell lines for TG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Autoimmune thyroid disease0.62
    2Insulin secretion
    Thyroid hormone synthesis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for TG):
        Thyroid hormone synthesis
    Autoimmune thyroid disease


    TG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for TG (P012663 ENSP000002206164) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110213, ENSP000003241734I2D: score=4 STRING: ENSP00000324173
    ASGR1P073063, ENSP000002692994I2D: score=1 STRING: ENSP00000269299
    CTSDP073393, ENSP000002366714I2D: score=1 STRING: ENSP00000236671
    APCSP027433, ENSP000002550404I2D: score=1 STRING: ENSP00000255040
    CANXP278243, ENSP000002474614I2D: score=1 STRING: ENSP00000247461
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation IBA--
    GO:0007165signal transduction NAS3016640
    GO:0007416NOT synapse assembly IRD--
    GO:0015705iodide transport IEA--
    GO:0030878thyroid gland development IEP15494458

    TG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TG (THYG)

    10/98 Novoseek inferred chemical compound relationships for TG gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iodine 91.3 525 1954313 (7), 9292948 (6), 12713257 (4), 19160311 (4) (see all 99)
    thyroxine 90.9 582 1466156 (7), 10229914 (6), 11694378 (4), 8890722 (4) (see all 99)
    iodide 83.8 155 10537174 (6), 16648292 (4), 19951699 (3), 20364596 (3) (see all 73)
    triiodothyronine 83.3 331 11288978 (4), 11694378 (4), 10822292 (4), 16477365 (3) (see all 99)
    sodium iodide 78.5 31 19050049 (2), 10090312 (1), 17199440 (1), 18430446 (1) (see all 21)
    diiodotyrosine 77.4 15 8900403 (3), 1954313 (1), 8651700 (1), 9717982 (1) (see all 7)
    iodotyrosine 73.2 15 15289438 (2), 1727828 (1), 9737985 (1), 1281126 (1) (see all 9)
    methimazole 69.9 8 14657389 (1), 1794603 (1), 1688155 (1), 8075781 (1) (see all 5)
    thyronine 66.5 6 9434803 (1), 9717982 (1), 9344702 (1), 9419438 (1)
    18f fluorodeoxyglucose 60.9 40 12186505 (4), 19910903 (2), 10452315 (2), 12656659 (2) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about TG / THYG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TG gene: 
    NM_003235.4  

    Unigene Cluster for TG:

    Thyroglobulin
    Hs.654591  [show with all ESTs]
    Unigene Representative Sequence: NM_003235
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000523901 ENST00000220616(uc003ytw.3 uc010mdw.3) ENST00000520769
    ENST00000523756(uc011ljb.2) ENST00000518097 ENST00000518505 ENST00000519178
    ENST00000518058 ENST00000519543(uc011ljc.2) ENST00000520197 ENST00000520089
    ENST00000519294 ENST00000524151 ENST00000522523 ENST00000522797 ENST00000518108
    ENST00000522996 ENST00000522809
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TG:
    hsa-miR-1303
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TG
    Clone
    Products:
         
    OriGene clones in human, mouse for TG (see all 5)
    OriGene ORF clones in mouse, rat for TG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TG (NM_001614)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TG
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TG

    Additional mRNA sequence: 

    AB209159.1 AK299197.1 AK303666.1 AK303667.1 BC127887.1 BC140933.1 S40807.1 S80793.1 
    X02154.1 X05615.1 

    24/80 DOTS entries (see all 80):

    DT.95202433  DT.95177266  DT.95219259  DT.91713338  DT.100826698  DT.100826700  DT.452683  DT.92472293 
    DT.120642240  DT.95333374  DT.120642266  DT.100826697  DT.100826709  DT.100826704  DT.120642467  DT.100826710 
    DT.120642305  DT.120642340  DT.91698313  DT.95333484  DT.100829949  DT.92472287  DT.95333469  DT.95246308 

    1041 AceView cDNA sequences (see top 24):

    BQ355719 AA385311 AU141466 AU141144 AU141984 BE168236 AA384835 AU141734 
    AU141513 AU159103 AU142105 AU141993 AU141924 AU142090 AA385571 AU141892 
    AU141941 AU141307 AU141574 AU141761 AU141633 AA385672 AU142009 AU141980 
    AU142057 AU142144 AU141116 BE168388 AU141176 AU141588 AU142091 AU141719 
    AU141091 AU142017 AU141644 AU142003 AU142020 AU141413 AU141760 AU142088 
    AU141143 AU141691 AU141782 BF841986 AU141815 AU141479 BI002777 AU141788 
    AU142006 AU159354 AU141250 AU142025 AU142142 AU141258 AU141188 AU141357 
    AU142167 AU142062 AU142187 AU142041 AU141288 AU142152 AU141411 AU141806 
    AA384524 AU141299 AU141558 AU142024 BE168382 AU142050 AA384674 AU141578 
    AU141206 AU141289 AU141519 AU141992 AU141858 AU141387 AU141572 AU141714 
    AI686243 AU141991 BE168159 AU141390 AU141219 AU141168 AU141888 AU141772 
    AU141774 AU141287 AU141146 AU159397 AU141920 AU142170 AU141264 AU158898 
    AU141461 AU142136 AU141368 AA385241 AU141981 AU141607 AU141269 AU141359 
    AU142061 AU141210 AU142169 AU141214 AU141198 AU141932 AU141172 AA384456 
    AU141859 AU141642 AU141692 AA384903 AU141123 AU141829 AU141959 AU141568 
    AU142107 AU142019 AU141709 AU141492 AU141589 AU141775 AU141553 AU141748 
    AU141240 AU141594 AA385264 AU141376 AU141904 AU141623 AU141229 AU141777 
    AU158954 AU141453 AU141999 AU141191 AU141877 AU141443 AU141831 BG948896 
    AU141653 AU142145 AA384424 BE169827 AU141763 BF844297 AU141683 AU141545 
    AU141693 AU141802 AU141956 AU141706 AU141204 AU142056 AU141420 AU141350 
    AU141986 AU159231 AU141247 BE931984 AU141366 AU142111 AU159481 AU141792 
    AU141754 AU141790 AU141152 AU141842 AU141684 AU141456 AU141473 AU141974 
    AU142069 AU141431 AU141923 AU141418 AU141182 AU141955 AU141902 AU141717 
    AU141459 AU141606 AU141155 AA385031 AU141967 AU141451 AU142018 S40807 
    AU142075 AU141571 AU141511 AU141584 AU142013 AU142166 AU142002 AU141641 
    BI000239 AU141628 AU141647 AU141224 AU141631 AU141809 AU141771 AU141958 
    AU141213 BE168393 AU141375 AU142149 AU142139 AU159100 AU141158 AU141850 
    BE175812 AU141800 AU141964 AA385060 BE168391 AU141303 AA384653 AU141975 
    AU141680 AU141222 BG995001 AU142021 BG178398 AU141412 AU159072 AU141921 
    AU141713 BE163041 BE931909 AU141654 AA384094 AU141735 AU141399 BG999814 
    AU141101 AU141227 AU158918 AU141873 AA385159 AA384545 AU141834 AU141768 
    AU141450 BF087299 AU142135 AA295587 BF741157 AU141786 AU141114 AU141108 
    AA868565 AU141560 AU141237 AU141455 BE810811 AU141502 AU141668 AA384481 
    AU141743 AU141445 AU158925 AU141836 AU141551 AU141470 BG187148 BE161450 
    AU159511 AU141995 AU141215 BX506769 AU159207 AA385746 AW135731 AU141251 
    AA384938 BF841923 AU141853 BX484701 AU159356 AU158856 AI420099 BG993242 
    AU141410 AL039612 AU141903 AU141122 AU141409 AU141758 BV190838 AU158831 
    AU141107 AU142071 AU141189 AU141197 AU141674 AU141596 AU141600 AU141712 
    AU159012 AU141136 BE168402 X05615 BE163464 AU141331 AU159487 AU158816 
    AU142141 AU141343 AU142001 AU141097 BE044620 X02154 BE707499 AU141918 
    BU680131 AU141585 AA295658 AU142026 AU159298 AU141153 NM_003235 AU141508 
    AU158920 U93033 AU141599 AU141246 AU141922 AA385219 AU142119 AU141783 
    AU141340 AU159453 AU141565 AU141525 AU159010 AU142127 AU141503 AU141810 
    BF841435 AU141117 AU159277 AU141566 AU141860 AU141395 AU141880 AU141408 
    AA385215 AU141102 AU141884 AU141259 AA384688 AU141835 AU141838 BE168389 
    BE168168 BE164958 AU141592 AW505008 AU142096 AU142143 AA384841 AU141598 
    AU141154 AU141580 AU142130 BG998814 CB986780 AU141333 AU141260 AU142151 
    AU141976 AU158967 AA384549 AU141235 BQ359843 AA384822 AU141323 AU142164 
    AA384409 AU141617 AU141867 AU141846 AU141878 BX485604 AU142046 AU141162 
    BE931901 AA384919 BG998994 AU141830 AU141799 BG999877 AW874093 AU141930 
    AA384400 AU142012 AU141381 BI004394 AU141839 AU159411 AU141851 AU141890 
    AA384349 AU158872 AW873976 AU141489 AU159015 AU142188 BI765505 BF841436 
    AU141100 AU141655 BG284464 BQ301274 AU141848 BF839930 AU141313 AU141485 
    AU142183 AU141926 AU141510 AU141341 AU141233 BV205066 AU142133 AU141544 
    AU141555 AU141139 BI005872 AU159107 AU141290 BQ359811 AU141127 BE810814 
    AU159499 AU141733 BX484514 AA384059 AU141440 AU141536 AU142126 AU141778 
    AU141540 AU141737 AU141970 AU142054 AU141621 AU141582 AA384391 AU159208 
    AU141135 AU159220 AU141263 AA385165 AA384923 AU141361 AL039611 AU141557 
    AU141192 AU158985 AU158984 AU158797 BI005725 BQ355699 BG948992 BE168232 
    BE045803 BF351279 BQ355499 AW780039 AU159096 AU159271 AA385340 AA385472 
    AU142116 BQ349693 BG992572 AU159202 BE169584 AA384340 BG948948 AA384233 
    AU159191 BG998990 CB958855 BG997301 BG948941 BF841500 BE161452 BE168387 
    BG990923 BG180901 AW874106 BQ355684 BE168028 CB959392 BF829865 AA384298 
    AA384397 BE168170 AU159245 AU159353 BI001931 AU159375 BQ350239 BQ355598 
    AW874044 AU158958 BE707406 BF741811 BE170507 AU159256 AU159246 CB987431 
    AU159399 BE163048 AW874015 AW874163 BF741106 BG997815 AA493892 AA385492 
    AU159251 BF351457 BG998825 AA383764 BF829383 BG949146 AU159000 BE163052 
    AU159255 AU159309 BI005485 BI003880 BG998816 AU158955 AU158994 BE044632 
    BF741096 BE163024 BG999822 AU141115 AU159358 BE046139 AU159407 AU159334 
    AA384009 BQ355712 AU159119 CB986174 BX484963 BE168379 AA632990 AU158986 
    BE163309 AA384597 BE707398 BI002682 AU159013 BF842113 AA385178 AU159241 
    BG998817 BE045832 BG998588 AU159055 AU159250 BQ355215 BE168380 AA493254 
    AU158786 AA632843 BE180756 BG997167 BF351670 AU158853 AU159139 BE168385 
    BI825164 BF828054 AU159377 AU158824 BF841317 BG991003 BG996444 AU158792 
    BE168166 AU159469 AU159295 AU159244 AU159424 AU159027 AA385405 BF842104 
    AU159237 AU159136 BF828051 AU159520 AU158849 BI005288 AU159310 BG997305 
    AU159372 AU141751 AU159049 AU159297 AU159509 AU159221 BE164858 AU159364 
    AW874192 BF841380 AU158775 BF741863 AU158993 BQ355583 AU158926 BI005065 
    BE839782 AU159192 BG999503 CB986845 BF352337 AU159223 BI004406 AU158828 
    AU158939 BE168384 AU158981 AU159483 AU158858 AU159234 BF839204 AW873962 
    AU159051 BG998902 BE163046 AU158935 BE707384 AU158800 AW873205 AU158851 
    AU159497 AU159531 AU159259 AU159249 AU159308 BE045197 BE168390 AU158841 
    AW872522 AU159240 BG999736 AU159017 BI005062 BG999518 BI004478 AU159115 
    AU159315 AU159011 AU158963 BQ354982 BF741404 AU159178 BE045301 AU159054 
    BG990585 AU159003 AU158765 AU158771 BF737686 BE710030 AU159307 BF841434 
    BF740320 AU158911 BE164901 AU159024 AU159056 BG990933 AU158845 AU159088 
    AU159043 BE707387 AU159182 AW874102 AU159160 AW874184 AU159290 AU159517 
    BE044612 AU158827 AA632570 BE707470 BF841679 BG998997 AW772580 BI004669 
    AU158788 AU159468 AU158837 BQ301622 AU159506 BF839304 AU159452 AU159020 
    BF741865 AU158844 BI003403 AU159210 AU159291 AU159501 BF828283 BF740325 
    BE707381 BG988555 AU159505 AU159161 AU159326 BG998472 AU141989 BE168392 
    BE163057 AU159193 AU159060 AU158766 AU158781 BI004110 BI004208 BE168452 
    AU158974 AU158774 AU159384 AU158980 BI005737 AU158770 BF829038 BI000515 
    AU159205 BI004407 AA384279 BE164856 BG999591 AU159327 BQ301333 BG998474 
    AU159305 BF841419 AU159064 AU159171 AU159454 BQ352195 AU158811 BQ359533 
    BE044805 BG948883 AU158948 BE707442 AA385458 AW780037 AU159458 AU159121 
    BF828432 BE177529 BE046055 BE044881 BG948996 AA384604 AU159117 AU159110 
    AU159079 BF839299 BI000001 BG995062 BI003311 BE168034 BF839938 AU159031 
    AU158838 AU159252 AU159101 BE161920 AU159098 AA493234 AU159005 BG992397 
    BG990601 AU159518 BQ359836 AU159144 AW874098 AA385295 AU159159 BI004569 
    BI000511 AA385316 BF841630 AA384458 AA618133 T29891 AU158938 AU159427 
    AU158778 BF741111 BE163039 AU159379 AU159400 BQ354849 BF841758 AU158889 
    BF841481 BI004838 AU159416 AU159300 AU158799 AU158990 AU159227 AU159138 
    AU159084 AU159294 BI004018 BE163091 AU159403 AU158819 AU159413 AW873383 
    BE707443 BE163045 AW959060 BF828446 AU159041 BE180754 BI002690 BE164899 
    BF842047 AA385689 BF838112 BE168164 AU159428 BI004161 BF838149 AU158870 
    BF829040 BQ359892 AU159490 AU159418 AU159112 AU159078 BF839199 CD616643 
    BI003650 BF829933 AA385655 BQ354808 BF841374 AA494222 BE159501 AU159292 
    AU159425 AU158950 AU159086 AU159419 BF837422 AU158813 AW874185 BF841326 
    AW293728 AU159521 AU159423 BF842795 AU159181 BF828285 AU158804 AU158866 
    BG999410 BG999920 BF828971 BE162862 BF829298 BG999165 BF843208 AU159089 
    AW873414 BE162859 AU159528 AU159333 AW874159 BG991296 BF741158 AU159410 
    BQ301341 AU159075 BI002776 BQ349608 BI000092 AU159343 AU158876 AU158971 
    BG991458 BE707360 AU158791 AU159151 BF841329 AU159512 BG994951 BF844196 
    AU159388 BE708582 BF740301 BI000513 AU159260 BI002683 BF841755 AU159496 
    AU159114 BF828904 BI003098 AU159106 BQ359537 BF741509 AU158798 BF844969 
    AA618136 AU159314 BF841316 BF841417 BE170273 BF827110 AU159392 AU158863 
    BQ301493 AU159448 BF828332 BF828445 BE708288 AU159385 AU159516 BF740435 
    BI000505 BF828968 BF845311 BF839932 AU159394 BG999915 BF828431 BF740312 
    BF828041 BF828335 BI002768 BE163067 BF829017 AU159153 BF829921 BF829936 
    BG995989 BE163225 BG999910 BI003326 BF837418 BI003983 BG997302 BE163259 
    BF828290 BE168728 BQ301620 BF829366 AU159442 BG999741 BG999926 AU159128 
    BG999556 BE163319 BG948885 BF829384 BF828333 BF740716 BF740715 BF828906 
    BG998519 BE162854 BF829293 AI214881 BI005490 BI004809 BI004212 BI003309 
    BQ301479 AU158983 BG998810 BQ301335 BF839943 BQ354759 BE162860 BE168386 
    BI004106 BE163303 BQ359758 AU159083 AW874088 BF842022 BE168060 BF828969 
    BG994899 BF841424 BE168031 BF844295 BF844505 BF740418 BI002988 BE163089 
    BE167394 BI005447 BF841927 BG949144 BG988567 BG999726 AA493563 BI001280 
    BF828900 BG999720 AW874198 AU159409 AW874215 BF741846 BG985041 CB958771 
    BQ301207 BF841363 BQ350447 BF841497 BE708540 BG999739 BG992356 BG999922 
    AU158888 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TG expression in normal human tissues (normalized intensities)      TG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TG Expression
    About this image


    TG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             Thyroid Progenitors ( Efficient derivation of purified lung and thyroid progenitor...
             thyroid gland ; glandular cells   
     
     Lung (Respiratory System)
             Immature proximal lung cells ( Directed differentiation of human embryonic stem cells...
     
     Gut Tube (Gastrointestinal Tract)
             Anterior foregut progenitor cells ( Directed differentiation of human embryonic stem...
     
     Lymph (Hematopoietic System)
             Lymphnode   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See TG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TG

    SOURCE GeneReport for Unigene cluster: Hs.654591

    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
    Tissue specificity: Thyroid gland specific

        SABiosciences Expression via Pathway-Focused PCR Array including TG: 
              Insulin Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TG gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tg1 , 5 thyroglobulin1, 5 78.6(n)1
    74.35(a)1
      15 (29.30 cM)5
    218191  NM_009375.21  NP_033401.21 
     666707535 
    chicken
    (Gallus gallus)
    Aves TG1 thyroglobulin 61.24(n)
    55.75(a)
      100857838  XM_003640868.1  XP_003640916.1 
    lizard
    (Anolis carolinensis)
    Reptilia TG6
    Uncharacterized protein
    53(a)
    1 ↔ 1
    4(662513-807612)
    zebrafish
    (Danio rerio)
    Actinopterygii tg1 thyroglobulin 50.71(n)
    42.07(a)
      567631  XM_689200.4  XP_694292.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Est-Q6
    CG92876
    (see all 7)
    --
    18(a)
    18(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    3L(21494521-21497059)
    2L(8676848-8679782)
    worm
    (Caenorhabditis elegans)
    Secernentea F55F3.26
    E01G6.36
    (see all 23)
    Protein E01G6.3
    (see all 23)
    20(a)
    19(a)
    (see all 23)
    possible ortholog
    possible ortholog
    (see all 23)
    X(13760290-13763993)
    X(12241716-12244652)


    ENSEMBL Gene Tree for TG (if available)
    TreeFam Gene Tree for TG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TG gene
    9 SIMAP similar genes for TG using alignment to 13 protein entries:     THYG_HUMAN (see all proteins):
    NLGN2    CES2    CES3    CES5A    NLGN3    DKFZp686F02202
    ACHE    BCHE    CES1P1

    TG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6587 SNPs in TG are shown (see all 6587)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0630374
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630372 R Q mis40--------
    VAR_0630354
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630352 C Y mis40--------
    VAR_0630364
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630362 A D mis40--------
    VAR_0630344
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630342 C Y mis40--------
    VAR_0630384
    Thyroid dyshormonogenesis 3 (TDH3)4--see VAR_0630382 G R mis40--------
    rs20767381,2,4
    C,HThyroid dyshormonogenesis 3 (TDH3)4 --134192929(+) TGATAT/CGTAGC 2 /R /C mis1 ese37Minor allele frequency- C:0.00EA NS NA 644
    rs20767391,2,4
    CThyroid dyshormonogenesis 3 (TDH3)4 pathogenic1134257890(+) TTGAAT/AGTGAA 2 /S /C mis11Minor allele frequency- A:0.00EA 220
    rs1219126481,2
    C,Fpathogenic1134168695(+) GATTCC/TGATGT 2 R * stg12Minor allele frequency- T:0.00NA EU 5871
    rs1219126461,2
    Cpathogenic1134209483(+) AGTATC/TGAGCC 2 R * stg10--------
    rs20695661,2,4
    Cpathogenic1134304022(+) GAGGCG/ACTTCC 2 /H /R mis1 ese33Minor allele frequency- A:0.00EA NA 20

    HapMap Linkage Disequilibrium report for TG (133879203 - 134129203 bp, first 250kb of TG)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for TG (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2622999CNV Insertion19546169
    nsv509279CNV Insertion20534489
    esv1530894CNV Insertion17803354
    nsv6403CNV Insertion18451855
    nsv6402CNV Insertion18451855
    nsv891456CNV Loss21882294
    nsv525105CNV Loss19592680
    esv33367CNV Loss17666407
    nsv465818CNV Loss19166990
    esv33561CNV Loss17666407


    Human Gene Mutation Database (HGMD): TG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TG
    DNA2.0 Custom Variant and Variant Library Synthesis for TG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188450   
    OMIM disorders: 274700  608175  
    UniProtKB/Swiss-Prot: THYG_HUMAN, P01266
  • Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing
    large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid
    dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a
    relatively high serum free triiodothyronine (T3) concentration with disproportionately low free
    tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue
    hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and
    intellectual defects in some cases. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related
    diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive
    T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2
    differentiation and activate B cells to produce antibodies against the TSH receptor, which stimulate the thyroid
    and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the
    thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 20/118 diseases for TG (see all 118):    About MalaCards
    goiter    struma ovarii    endemic goiter    nontoxic goiter
    malignant struma ovarii    laryngocele    suppurative thyroiditis    thyroid dyshormonogenesis 3
    hypothyroidism    autoimmune thyroiditis    graves' disease    hashimoto's encephalitis
    thyroxine-binding globulin deficiency    iodine hypothyroidism    subacute thyroiditis    nodular goiter
    myxedema    non-herpetic acute limbic encephalitis    toxic diffuse goiter    multinodular goiter

    12 diseases from the University of Copenhagen DISEASES database for TG:
    Thyroid cancer     Autoimmune thyroiditis     Goiter     Hypothyroidism
    Hyperthyroidism     Thyrotoxicosis     Subacute thyroiditis     Carcinoma
    Thyroid adenoma     Adenoma     Teratoma     Suppurative thyroiditis

    TG for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for TG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 95.4 414 17892441 (5), 18630997 (4), 19160311 (4), 11325833 (3) (see all 99)
    thyroid cancer 95 436 17302864 (4), 14588101 (3), 16479246 (3), 18613899 (3) (see all 99)
    autoimmune thyroid disease 92.8 143 10570317 (3), 15096179 (3), 2256432 (2), 14973426 (2) (see all 78)
    hashimotos thyroiditis 90.5 101 2242608 (3), 2226281 (2), 10670755 (2), 7962336 (2) (see all 69)
    graves disease 89.4 145 16646680 (3), 1724781 (2), 10984889 (2), 11092696 (2) (see all 85)
    thyroid diseases 89.1 126 18243140 (4), 10984889 (3), 11228272 (3), 12022704 (3) (see all 72)
    goiter 88.5 123 2129364 (4), 1851064 (4), 7549998 (3), 9588493 (2) (see all 79)
    goiter congenital 88.5 55 10199792 (3), 14764776 (2), 8325944 (2), 15769978 (2) (see all 33)
    hypothyroidism 88.4 117 9790265 (3), 15014299 (2), 8966023 (2), 17978827 (2) (see all 84)
    thyroid papillary carcinoma 87.6 64 15579752 (2), 1305063 (2), 16033735 (2), 16201895 (2) (see all 37)

    Genatlas disease: TG
    goiter associated to hypothyroidism and variant type of adenomatous goiter

    Genetic Association Database (GAD): TG
    Human Genome Epidemiology (HuGE) Navigator: TG (885 documents)

    Export disorders for TG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TG gene, integrated from 9 sources (see all 1762):
    (articles sorted by number of sources associating them with TG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. (PubMed id 19509106)1, 2, 9 Pardo V.... Medeiros-Neto G. (2009)
    2. Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (PubMed id 10199792)1, 2, 9 Hishinuma A.... Ieiri T. (1999)
    3. Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent- exposed regions of the primary structure. (PubMed id 8269951)1, 2, 9 Gentile F. and Salvatore G. (1993)
    4. A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. (PubMed id 16477365)1, 2, 9 Kitanaka S....Igarashi T. (2006)
    5. Characterization of the type-1 repeat from thyroglobulin, a cysteine- rich module found in proteins from different families. (PubMed id 8797845)1, 2, 9 Molina F.... Granier C. (1996)
    6. Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. (PubMed id 7793989)1, 2, 9 Xiao S.... Rawitch A.B. (1995)
    7. Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes. (PubMed id 20215770)1, 4, 9 Kotnik P....Battelino T. (2010)
    8. Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. (PubMed id 19034705)1, 4, 9 Maierhaba M....Dong B.N. (2008)
    9. Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. (PubMed id 18385936)1, 4, 9 Hsiao J.Y....Ke D.S. (2008)
    10. Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. (PubMed id 18755875)1, 4, 9 Hsiao J.Y....Ke D.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7038 HGNC: 11764 AceView: TG Ensembl:ENSG00000042832 euGenes: HUgn7038
    ECgene: TG Kegg: 7038 H-InvDB: TG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TG Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Thyroglobulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TG gene:
    Search GeneIP for patents involving TG

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore Custom Antibody & Bulk Services
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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