Aliases for TFRC Gene
External Ids for TFRC Gene
Previous GeneCards Identifiers for TFRC Gene
GeneCards Summary for TFRC Gene
TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include gastric adenosquamous carcinoma and berger disease. Among its related pathways are Endocytosis and HIF-1 signaling pathway. GO annotations related to this gene include identical protein binding and transferrin receptor activity. An important paralog of this gene is FOLH1.
UniProtKB/Swiss-Prot for TFRC Gene
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.