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Aliases for TFPT Gene

Aliases for TFPT Gene

  • TCF3 (E2A) Fusion Partner (In Childhood Leukemia) 2 3
  • INO80 Complex Subunit F 2 3 4
  • INO80F 3 4
  • Amida 2 3
  • Amida, Partner Of The E2A 3
  • TCF3 Fusion Partner 3
  • Partner Of The E2A 2
  • Protein FB1 4
  • FB1 3

External Ids for TFPT Gene

Summaries for TFPT Gene

GeneCards Summary for TFPT Gene

TFPT (TCF3 (E2A) Fusion Partner (In Childhood Leukemia)) is a Protein Coding gene. Diseases associated with TFPT include childhood leukemia and neuroblastoma. GO annotations related to this gene include protein heterodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for TFPT Gene

  • Appears to promote apoptosis in a p53/TP53-independent manner

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

Gene Wiki entry for TFPT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPT Gene

Genomics for TFPT Gene

Genomic Location for TFPT Gene

Start:
54,107,013 bp from pter
End:
54,115,675 bp from pter
Size:
8,663 bases
Orientation:
Minus strand

Genomic View for TFPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPT Gene

Regulatory Elements for TFPT Gene

Proteins for TFPT Gene

  • Protein details for TFPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1Z6-TFPT_HUMAN
    Recommended name:
    TCF3 fusion partner
    Protein Accession:
    P0C1Z6
    Secondary Accessions:

    Protein attributes for TFPT Gene

    Size:
    253 amino acids
    Molecular mass:
    28278 Da
    Quaternary structure:
    • Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

neXtProt entry for TFPT Gene

Proteomics data for TFPT Gene at MOPED

Post-translational modifications for TFPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFPT Gene

No data available for DME Specific Peptides for TFPT Gene

Domains for TFPT Gene

Gene Families for TFPT Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for TFPT Gene

ProtoNet:
genes like me logo Genes that share domains with TFPT: view

No data available for UniProtKB/Swiss-Prot for TFPT Gene

Function for TFPT Gene

Molecular function for TFPT Gene

UniProtKB/Swiss-Prot Function: Appears to promote apoptosis in a p53/TP53-independent manner
UniProtKB/Swiss-Prot Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

Gene Ontology (GO) - Molecular Function for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 17395368
GO:0019901 protein kinase binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TFPT: view

Phenotypes for TFPT Gene

GenomeRNAi human phenotypes for TFPT:
genes like me logo Genes that share phenotypes with TFPT: view

miRNA for TFPT Gene

miRTarBase miRNAs that target TFPT

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TFPT Gene

Localization for TFPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFPT Gene COMPARTMENTS Subcellular localization image for TFPT gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm ISS --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with TFPT: view

Pathways for TFPT Gene

SuperPathways for TFPT Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process --
genes like me logo Genes that share ontologies with TFPT: view

No data available for Pathways by source for TFPT Gene

Compounds for TFPT Gene

(40) Novoseek inferred chemical compound relationships for TFPT Gene

Compound -log(P) Hits PubMed IDs
aminopentol 93.5 7
sphinganine 88.2 19
tricarballylate 83.8 1
sphingosine 80.6 19
deoxynivalenol 79.2 30
genes like me logo Genes that share compounds with TFPT: view

Transcripts for TFPT Gene

Unigene Clusters for TFPT Gene

TCF3 (E2A) fusion partner (in childhood Leukemia):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFPT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TFPT Gene

GeneLoc Exon Structure for
TFPT
ECgene alternative splicing isoforms for
TFPT

Expression for TFPT Gene

mRNA expression in normal human tissues for TFPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFPT Gene

SOURCE GeneReport for Unigene cluster for TFPT Gene Hs.590939

genes like me logo Genes that share expressions with TFPT: view

Orthologs for TFPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFPT 36
  • 99.34 (n)
  • 100 (a)
TFPT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFPT 36
  • 89.24 (n)
  • 96.41 (a)
TFPT 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFPT 36
  • 88.54 (n)
  • 95.26 (a)
TFPT 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfpt 36
  • 87.28 (n)
  • 91.16 (a)
Tfpt 16
Tfpt 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TFPT 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFPT 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfpt 36
  • 87.22 (n)
  • 91.25 (a)
lizard
(Anolis carolinensis)
Reptilia TFPT 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20229 36
tfpt 36
  • 61.3 (n)
  • 60.17 (a)
zebrafish
(Danio rerio)
Actinopterygii TFPT 37
  • 47 (a)
OneToOne
Species with no ortholog for TFPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFPT Gene

ENSEMBL:
Gene Tree for TFPT (if available)
TreeFam:
Gene Tree for TFPT (if available)

Paralogs for TFPT Gene

No data available for Paralogs for TFPT Gene

Variants for TFPT Gene

Sequence variations from dbSNP and Humsavar for TFPT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs181893 -- 54,110,891(+) AACTT(C/G)TTTct intron-variant
rs254262 -- 54,109,321(-) TGCCT(C/T)TGCTA intron-variant
rs254263 -- 54,108,253(-) CTCCT(C/G)CCTGC intron-variant
rs254264 -- 54,107,669(-) GAGTG(C/G)AAGGG intron-variant
rs254267 -- 54,112,306(+) tgggt(A/G)catta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFPT Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv510773 CNV Loss 20534489
nsv470157 CNV Loss 18288195
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
esv2718853 CNV Deletion 23290073
esv2718854 CNV Deletion 23290073
esv1362488 CNV Insertion 17803354

Relevant External Links for TFPT Gene

HapMap Linkage Disequilibrium report
TFPT

Disorders for TFPT Gene

UniProtKB/Swiss-Prot

TFPT_HUMAN
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

(12) Novoseek inferred disease relationships for TFPT Gene

Disease -log(P) Hits PubMed IDs
animal diseases 64.2 5
leukemogenesis 18.8 2
edema 16.1 3
tumors 2.6 3
leukemia 0 3

Relevant External Links for TFPT

Genetic Association Database (GAD)
TFPT
genes like me logo Genes that share disorders with TFPT: view

Publications for TFPT Gene

  1. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PMID: 10086727) Brambillasca F. … Privitera E. (Leukemia 1999) 3 4 23
  2. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PMID: 17041757) Franchini C. … Privitera E. (Apoptosis 2006) 3 4 23
  3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. (PMID: 10644725) Irie Y. … Miki N. (J. Biol. Chem. 2000) 2 3

Products for TFPT Gene

  • Addgene plasmids for TFPT

Sources for TFPT Gene

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