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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFPT Gene

protein-coding   GIFtS: 50
GCID: GC19M054610

TCF3 (E2A) Fusion Partner (In Childhood Leukemia)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TCF3 (E2A) Fusion Partner (In Childhood Leukemia)1 2     FB12
INO80 Complex Subunit F1 2 3     Amida, Partner Of The E2A2
amida1 2     TCF3 Fusion Partner2
INO80F2 3     Protein FB13
Partner Of The E2A1     

External Ids:    HGNC: 136301   Entrez Gene: 298442   Ensembl: ENSG000001056197   OMIM: 6095195   UniProtKB: P0C1Z63   

Export aliases for TFPT gene to outside databases

Previous GC identifers: GC19M055256 GC19M055034 GC19M059286 GC19M059302 GC19M050926


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TFPT Gene: 
TFPT (TCF3 (E2A) fusion partner (in childhood Leukemia)) is a protein-coding gene. Diseases associated with TFPT include childhood leukemia, and eaf. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
Function: Appears to promote apoptosis in a p53/TP53-independent manner
Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
transcriptional regulation, DNA replication and probably DNA repair

Gene Wiki entry for TFPT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFPT gene promoter:
         TBP   Pax-2   Pax-2a   Egr-4   C/EBPalpha   AREB6   PPAR-gamma1   COMP1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFPT promoter sequence
   Search SABiosciences Chromatin IP Primers for TFPT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13

TFPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054610:  view genomic region     (about GC identifiers)

Start:
54,610,320 bp from pter      End:
54,619,055 bp from pter
Size:
8,736 bases      Orientation:
minus strand

6/8 alternative locations (see all 8):
Chr19-,NW_003571061 81,433-90,168      Chr19-,NW_003571055 81,433-90,168      Chr19-,NW_003571057 81,433-90,168     
Chr19-,NW_003571059 81,433-90,168      Chr19-,NW_003571058 81,433-90,168      Chr19-,NW_003571054 81,433-90,168     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6 (See protein sequence)
Recommended Name: TCF3 fusion partner  
Size: 253 amino acids; 28278 Da
Subunit: Interacts with NOL3 (By similarity). Component of the chromatin remodeling INO80 complex; specifically
part of a complex module associated with the N-terminus of INO80
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for TFPT: NX_P0C1Z6

Explore proteomics data for TFPT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C1Z6

  • TFPT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFPT Protein Expression
    REFSEQ proteins: NP_037474.1  
    ENSEMBL proteins: 
     ENSP00000375639   ENSP00000375638   ENSP00000395180   ENSP00000375637  

    Human Recombinant Protein Products for TFPT: 
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    Novus Biologicals TFPT Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFPT 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005884actin filament IEA--
    GO:0031011Ino80 complex IDA--

    TFPT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TFPT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    INO80: INO80 complex subunits

    ProtoNet protein and cluster: P0C1Z6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPT_HUMAN, P0C1Z6
    Function: Appears to promote apoptosis in a p53/TP53-independent manner
    Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
    transcriptional regulation, DNA replication and probably DNA repair

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI17395368
    GO:0019901protein kinase binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TFPT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TFPT:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFPT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFPT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFPT 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFPT
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                         Customized lentivirus expression plasmids for stable overexpression of TFPT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFPT

    5/23 Interacting proteins for TFPT (P0C1Z61, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EAF2Q96CJ11, 3EBI-1245626,EBI-1245604 I2D: score=3 
    UCHL5Q9Y5K51, 3EBI-1245626,EBI-1051183 I2D: score=2 
    EAF1Q96JC93I2D: score=3 
    ELLP551993I2D: score=3 
    PAWRQ96IZ03I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0097190apoptotic signaling pathway IDA17041757

    TFPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFPT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFPT

    10/40 Novoseek inferred chemical compound relationships for TFPT gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminopentol 93.5 8 9473533 (1), 9668088 (1), 8089434 (1), 10528731 (1) (see all 7)
    sphinganine 88.2 33 9473533 (4), 9668088 (2), 9892062 (2), 11223085 (1) (see all 14)
    tricarballylate 83.8 2 8914830 (1)
    sphingosine 80.6 23 11223085 (2), 10496371 (2), 9892062 (2), 9988695 (1) (see all 16)
    deoxynivalenol 79.2 42 16019124 (7), 14630058 (6), 17109910 (3), 16968296 (2) (see all 13)
    zearalenone 75.2 27 16019124 (7), 10560568 (3), 17109910 (3), 16019843 (2) (see all 9)
    ceramide 73.5 28 9668088 (3), 17030510 (2), 11815611 (2), 19937735 (2) (see all 18)
    moniliformin 70.9 18 11848570 (5), 11131899 (2), 14708984 (1)
    nivalenol 66.1 17 14630058 (6), 8612007 (2), 10560568 (2), 11955675 (1)
    o phthalaldehyde 65 4 8854911 (1), 9735014 (1), 7580311 (1)

    Search CenterWatch for drugs/clinical trials and news about TFPT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFPT gene: 
    NM_013342.3  

    Unigene Cluster for TFPT:

    TCF3 (E2A) fusion partner (in childhood Leukemia)
    Hs.590939  [show with all ESTs]
    Unigene Representative Sequence: BM810210
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391759(uc010yej.1 uc010erd.2) ENST00000391758 ENST00000420715
    ENST00000391757
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TFPT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TFPT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFPT
    Clone
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    GenScript: all cDNA clones in your preferred vector: TFPT (NM_013342)
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    Sirion Biotech Customized lentivirus for stable overexpression of TFPT 
                         Customized lentivirus expression plasmids for stable overexpression of TFPT 
    Primer
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    OriGene qPCR primer pairs and template standards for TFPT
    OriGene qSTAR qPCR primer pairs in human, mouse for TFPT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFPT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFPT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFPT

    Additional mRNA sequence: 

    AF052052.1 AK310627.1 AK310647.1 BC001728.1 BC004281.1 BC007776.2 

    10 DOTS entries:

    DT.447997  DT.110917  DT.97845460  DT.91734404  DT.100785299  DT.97833336  DT.100785303  DT.121451716 
    DT.440286  DT.92428332 

    24/138 AceView cDNA sequences (see all 138):

    CB217569 BM559611 BQ063803 BG761638 AI983968 BM788137 BQ066031 BQ066137 
    BG684666 BM557097 BU160949 BG757617 BE892562 AI537231 BG763205 CR590072 
    CA748983 BQ772644 CB160743 BQ368294 BM694332 BQ637509 BM554251 CB150805 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TFPT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -                                       
    SP2:                                      -                 -                     
    SP3:                                      -                                       
    SP4:                                      -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for TFPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFPT expression in normal human tissues (normalized intensities)      TFPT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAATAAAC
    TFPT Expression
    About this image


    TFPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See TFPT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFPT

    SOURCE GeneReport for Unigene cluster: Hs.590939
        SABiosciences Custom PCR Arrays for TFPT
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TFPT gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpt1 , 5 TCF3 (E2A) fusion partner1, 5 88.35(n)1
    92.37(a)1
      7 (2.09 cM)5
    697141  NM_023524.11  NP_076013.11 
     36203245 
    lizard
    (Anolis carolinensis)
    Reptilia TFPT6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343279.1(1538266-1541399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202292 Transcribed sequence with weak similarity to protein refNP_037474.1 (H.sapiens) TCF3 (E2A) fusion partner (in childhood Leukemia); amida, partner of the E2A [Homo sapiens] less 76.29(n)    142014429 
    zebrafish
    (Danio rerio)
    Actinopterygii tfpt1 TCF3 fusion partner homolog 57.08(n)
    57.52(a)
      796934  NM_001160707.1  NP_001154179.1 


    ENSEMBL Gene Tree for TFPT (if available)
    TreeFam Gene Tree for TFPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/210 SNPs in TFPT are shown (see all 210)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2542641,2
    C,F,A,H--54610976(-) GAGTGC/GAAGGG 1 -- int1 trp317Minor allele frequency- G:0.48NS EA NA WA CSA 791
    rs775779611,2
    F--54610982(+) CACTCC/TGTCTT 1 -- int12Minor allele frequency- T:0.15CSA WA 119
    rs665060161,2
    C,F--54610983(+) ACTCCG/TTCTTC 1 -- int12Minor allele frequency- T:0.05CSA NA 121
    rs1850496601,2
    --54611111(+) TCCAAC/TTACTT 1 -- int10--------
    rs560618121,2
    C,F--54611131(+) ATCCTA/GGGCCT 1 -- int15Minor allele frequency- G:0.08CSA WA NA EA 361
    rs1464928651,2
    --54611217(+) AAGAGC/TCCTGA 1 -- int10--------
    rs1886602871,2
    --54611227(+) AACCTA/GACTCA 1 -- int10--------
    rs771471731,2
    C,F--54611283(+) ACTGGA/C/TGCCGG 1 -- int12WA NA 238
    rs6211491,2
    C--54611284(-) GCCGGC/TGCCAG 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs6211471,2
    C,F,A,H--54611287(-) AGAGCC/TGGCGC 1 -- int122Minor allele frequency- T:0.46NS EA NA WA CSA 2347

    HapMap Linkage Disequilibrium report for TFPT (54610320 - 54619055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TFPT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718854CNV Deletion23290073
    esv2718853CNV Deletion23290073
    esv2718812CNV Deletion23290073
    esv1362488CNV Insertion17803354
    nsv515623CNV Loss19592680
    nsv470157CNV Loss18288195
    nsv510773CNV Loss20534489
    nsv833877CNV Loss17160897
    dgv4001n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TFPT
    DNA2.0 Custom Variant and Variant Library Synthesis for TFPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609519    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Inversion inv(19)(p13;q13) with TCF3

  • 20/21 diseases for TFPT (see all 21):    About MalaCards
    childhood leukemia    eaf    differentiating neuroblastoma    acute lymphoblastic leukemia
    neural tube defects    esophageal cancer    lymphoblastic leukemia    papilloma
    neuroblastoma    retinal disease    lung adenocarcinoma    glioblastoma
    leukemia    retinoblastoma    esophagitis    atherosclerosis
    mental retardation    adenocarcinoma    thyroiditis    retinitis


    TFPT for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for TFPT gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    animal diseases 64.2 5 1628862 (1), 9384738 (1), 10575354 (1), 9725030 (1) (see all 5)
    leukemogenesis 18.8 2 17041757 (2)
    edema 16.1 3 12153764 (1), 7582616 (1), 9719762 (1)
    tumors 2.6 3 8602837 (1), 14988222 (1), 8917690 (1)
    leukemia 0 6 17395368 (2), 11700047 (1)
    necrosis 0 4 16412405 (1), 11875625 (1), 9719762 (1), 14630058 (1)
    renal disease 0 1 8761355 (1)
    glioma 0 6 10739748 (1), 15297026 (1), 10839479 (1)
    glioblastoma 0 3 15621711 (2), 15337581 (1)
    carcinoma 0 1 15718252 (1)

    Genetic Association Database (GAD): TFPT

    Export disorders for TFPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFPT gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with TFPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PubMed id 17041757)1, 2, 9 Franchini C....Privitera E. (2006)
    3. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)1, 2, 9 Brambillasca F.... Privitera E. (1999)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. (PubMed id 10644725)1, 3 Irie Y....Miki N. (2000)
    9. FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. (PubMed id 17395368)1, 9 Jiang F....Wang Z. (2007)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29844 HGNC: 13630 AceView: TFPT Ensembl:ENSG00000105619 euGenes: HUgn29844
    ECgene: TFPT H-InvDB: TFPT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFPT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFPT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFPT gene:
    Search GeneIP for patents involving TFPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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