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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFPT Gene

protein-coding   GIFtS: 47
GCID: GC19M054610

TCF3 (E2A) fusion partner (in childhood Leukemia)

 Explore 22 diseases affiliated with
TFPT via our new
 Human Malady Compendium 
Biological research products
for TFPT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TCF3 (E2A) Fusion Partner (In Childhood Leukemia)1 2     INO80 Complex Subunit F2 3
INO80F1 2 3     Amida, Partner Of The E2A2
FB11 2     TCF3 Fusion Partner2
Amida1     Protein FB13

External Ids:    HGNC: 136301   Entrez Gene: 298442   Ensembl: ENSG000001056197   OMIM: 6095195   UniProtKB: P0C1Z63   

Export aliases for TFPT gene to outside databases

Previous GC identifers: GC19M055256 GC19M055034 GC19M059286 GC19M059302 GC19M050926


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
Function: Appears to promote apoptosis in a p53/TP53-independent manner
Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair

Gene Wiki entry for TFPT


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFPT gene promoter:
         TBP   Pax-2   Pax-2a   Egr-4   C/EBPalpha   AREB6   PPAR-gamma1   COMP1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFPT promoter sequence
   Search SABiosciences Chromatin IP Primers for TFPT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13

TFPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054610:  view genomic region     (about GC identifiers)

Start:
54,610,320 bp from pter      End:
54,619,055 bp from pter
Size:
8,736 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6 (See protein sequence)
Recommended Name: TCF3 fusion partner  
Size: 253 amino acids; 28278 Da
Subunit: Interacts with NOL3 (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of
a complex module associated with the N-terminus of INO80
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for TFPT: NX_P0C1Z6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0C1Z6

  • TFPT Protein expression data from MOPED and PaxDb:    About this image 
    TFPT Protein Expression
    REFSEQ proteins: NP_037474.1  
    ENSEMBL proteins: 
     ENSP00000375639   ENSP00000375638   ENSP00000375637   ENSP00000395180  

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    Uscn Proteins for TFPT

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005884actin filament IEA--
    GO:0031011Ino80 complex IDA--

    TFPT for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P0C1Z6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPT_HUMAN, P0C1Z6
    Function: Appears to promote apoptosis in a p53/TP53-independent manner
    Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI19615732
    GO:0019901protein kinase binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TFPT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TFPT:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TFPT 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFPT

    5/23 Interacting proteins for TFPT (P0C1Z61, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EAF2Q96CJ11, 3EBI-1245626,EBI-1245604 I2D: score=3 
    UCHL5Q9Y5K51, 3EBI-1245626,EBI-1051183 I2D: score=2 
    EAF1Q96JC93I2D: score=3 
    ELLP551993I2D: score=3 
    PAWRQ96IZ03I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--

    TFPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFPT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFPT
    10/40 Novoseek chemical compound relationships for TFPT gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminopentol 93.5 8 9473533 (1), 9668088 (1), 8089434 (1), 10528731 (1) (see all 7)
    sphinganine 88.2 33 9473533 (4), 9668088 (2), 9892062 (2), 11223085 (1) (see all 14)
    tricarballylate 83.8 2 8914830 (1)
    sphingosine 80.6 23 11223085 (2), 10496371 (2), 9892062 (2), 9988695 (1) (see all 16)
    deoxynivalenol 79.2 42 16019124 (7), 14630058 (6), 17109910 (3), 16968296 (2) (see all 13)
    zearalenone 75.2 27 16019124 (7), 10560568 (3), 17109910 (3), 16019843 (2) (see all 9)
    ceramide 73.5 28 9668088 (3), 17030510 (2), 11815611 (2), 19937735 (2) (see all 18)
    moniliformin 70.9 18 11848570 (5), 11131899 (2), 14708984 (1)
    nivalenol 66.1 17 14630058 (6), 8612007 (2), 10560568 (2), 11955675 (1)
    o phthalaldehyde 65 4 8854911 (1), 9735014 (1), 7580311 (1)

    Search CenterWatch for drugs/clinical trials and news about TFPT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFPT gene: 
    NM_013342.3  

    Unigene Cluster for TFPT:

    TCF3 (E2A) fusion partner (in childhood Leukemia)
    Hs.743503  [show with all ESTs]
    Unigene Representative Sequence: BM810210
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391759(uc010yej.1 uc010erd.2) ENST00000391758 ENST00000391757
    ENST00000420715

    miRNA
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    Additional cDNA sequence: 

    AF052052.1 AK310627.1 AK310647.1 BC001728.1 BC004281.1 BC007776.2 

    10 DOTS entries:

    DT.447997  DT.110917  DT.97845460  DT.91734404  DT.97833336  DT.100785299  DT.100785303  DT.121451716 
    DT.440286  DT.92428332 

    24/138 AceView cDNA sequences (see all 138):

    BE252714 AI537231 BM980160 BQ063803 AI199756 CA748983 BM788137 BE892562 
    CB217569 BM712159 AI927571 CA449589 BQ368294 AI674373 BU625886 BG763205 
    CF541358 CR590072 BQ670942 BM704835 CB150805 BM558514 BQ672964 BM794744 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TFPT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -                                       
    SP2:                                      -                 -                     
    SP3:                                      -                                       
    SP4:                                      -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for TFPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCAATAAAC
    TFPT Expression
    About this image
    See TFPT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFPT

    SOURCE GeneReport for Unigene cluster: Hs.743503
        SABiosciences Custom PCR Arrays for TFPT

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TFPT gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpt1 , 5 TCF3 (E2A) fusion partner1, 5 88.35(n)1
    92.37(a)1
      7 (2.09 cM)5
    697141  NM_023524.11  NP_076013.11 
     36203245 
    lizard
    (Anolis carolinensis)
    Reptilia TFPT6
    --
    60(a)
    1 ↔ 1
    GL343279.1(1538266-1541399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202292 Transcribed sequence with weak similarity to protein more 76.29(n)    142014429 
    zebrafish
    (Danio rerio)
    Actinopterygii tfpt1 TCF3 fusion partner homolog 57.08(n)
    57.52(a)
      796934  NM_001160707.1  NP_001154179.1 


    ENSEMBL Gene Tree for TFPT (if available)
    TreeFam Gene Tree for TFPT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in TFPT are shown (see all 163    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2542641,2
    C,F,A,H--54610976(-) GAGTGC/GAAGGG 1 -- int1 trp317Minor allele frequency- G:0.48NS EA NA WA CSA 791
    rs775779611,2
    --54610982(+) CACTCC/TGTCTT 1 -- int12Minor allele frequency- T:0.15CSA WA 119
    rs665060161,2
    C--54610983(+) ACTCCG/TTCTTC 1 -- int12Minor allele frequency- T:0.05CSA NA 121
    rs1850496601,2
    --54611111(+) TCCAAC/TTACTT 1 -- int10--------
    rs560618121,2
    C--54611131(+) ATCCTA/GGGCCT 1 -- int15Minor allele frequency- G:0.08CSA WA NA EA 361
    rs1464928651,2
    --54611217(+) AAGAGC/TCCTGA 1 -- int10--------
    rs1886602871,2
    --54611227(+) AACCTA/GACTCA 1 -- int10--------
    rs771471731,2
    C,F--54611283(+) ACTGGA/C/TGCCGG 1 -- int12WA NA 238
    rs6211491,2
    C--54611284(-) GCCGGC/TGCCAG 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs6211471,2
    C,F,A,H--54611287(-) AGAGCC/TGGCGC 1 -- int122Minor allele frequency- T:0.46NS EA NA WA CSA 2347

    HapMap Linkage Disequilibrium report for TFPT (54610320 - 54619055 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TFPT
         1 CNV: 50206

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TFPT for disorders           About GeneDecksing

    OMIM gene information: 609519    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL).
  • Inversion inv(19)(p13;q13) with TCF3

    20/22 diseases for TFPT (see all 22):    About MalaCards
    childhood leukemia    pre-b-cell acute lymphoblastic leukemia    neural tube defect    leukemia
    acute lymphoblastic leukemia    lymphoblastic leukemia    differentiating neuroblastoma    eaf
    papilloma    lung adenocarcinoma    glioblastoma    liver cancer
    esophageal cancer    esophagitis    neuroblastoma    adenocarcinoma
    atherosclerosis    cholesterol    thyroiditis    carcinoma

    10/12 Novoseek disease relationships for TFPT gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    animal diseases 64.2 5 1628862 (1), 9384738 (1), 10575354 (1), 9725030 (1) (see all 5)
    leukemogenesis 18.8 2 17041757 (2)
    edema 16.1 3 12153764 (1), 7582616 (1), 9719762 (1)
    tumors 2.6 3 8602837 (1), 14988222 (1), 8917690 (1)
    leukemia 0 6 17395368 (2), 11700047 (1)
    necrosis 0 4 16412405 (1), 11875625 (1), 9719762 (1), 14630058 (1)
    renal disease 0 1 8761355 (1)
    glioma 0 6 10739748 (1), 15297026 (1), 10839479 (1)
    glioblastoma 0 3 15621711 (2), 15337581 (1)
    carcinoma 0 1 15718252 (1)


    Export disorders for TFPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFPT gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with TFPT)
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    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PubMed id 17041757)1, 2, 9 Franchini C....Privitera E. (2006)
    3. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)1, 2, 9 Brambillasca F.... Privitera E. (1999)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. (PubMed id 10644725)1, 3 Irie Y....Miki N. (2000)
    9. FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. (PubMed id 17395368)1, 9 Jiang F....Wang Z. (2007)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29844 HGNC: 13630 AceView: TFPT Ensembl:ENSG00000105619 euGenes: HUgn29844
    ECgene: TFPT H-InvDB: TFPT

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFPT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFPT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFPT gene:
    Search GeneIP for patents involving TFPT

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