Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TFPT Gene

Aliases for TFPT Gene

  • TCF3 Fusion Partner 2 3 5
  • INO80 Complex Subunit F 2 3 4
  • TCF3 (E2A) Fusion Partner (In Childhood Leukemia) 2 3
  • Amida, Partner Of The E2A 2 3
  • INO80F 3 4
  • Protein FB1 4
  • Amida 3
  • FB1 3

External Ids for TFPT Gene

Previous GeneCards Identifiers for TFPT Gene

  • GC19M055256
  • GC19M055034
  • GC19M059286
  • GC19M059302
  • GC19M054610
  • GC19M050926

Summaries for TFPT Gene

GeneCards Summary for TFPT Gene

TFPT (TCF3 Fusion Partner) is a Protein Coding gene. Diseases associated with TFPT include Childhood Leukemia. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Metabolism of proteins. GO annotations related to this gene include protein heterodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for TFPT Gene

  • Appears to promote apoptosis in a p53/TP53-independent manner.

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Wiki entry for TFPT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPT Gene

Genomics for TFPT Gene

Regulatory Elements for TFPT Gene

Enhancers for TFPT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053961 1.1 FANTOM5 ENCODE 3.4 +153.6 153561 0.3 PKNOX1 CREB3L1 NFRKB SIN3A GLI4 ZBTB40 GLIS2 ZNF366 EGR2 YY2 CACNG8 TFPT NDUFA3 CACNG7 MYADM PRPF31 PIR36356
GH19F053864 1 FANTOM5 ENCODE 1.7 +246.8 246761 9.8 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF845 ZNF765 ZNF816 ENSG00000235681 ZNF813 TPM3P6 LENG8-AS1 MYADM ZNF525 ZNF665
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TFPT on UCSC Golden Path with GeneCards custom track

Promoters for TFPT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000348799 375 2601 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TFPT Gene

Chromosome:
19
Start:
54,107,013 bp from pter
End:
54,115,675 bp from pter
Size:
8,663 bases
Orientation:
Minus strand

Genomic View for TFPT Gene

Genes around TFPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPT Gene

Proteins for TFPT Gene

  • Protein details for TFPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1Z6-TFPT_HUMAN
    Recommended name:
    TCF3 fusion partner
    Protein Accession:
    P0C1Z6

    Protein attributes for TFPT Gene

    Size:
    253 amino acids
    Molecular mass:
    28278 Da
    Quaternary structure:
    • Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

neXtProt entry for TFPT Gene

Post-translational modifications for TFPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFPT Gene

No data available for DME Specific Peptides for TFPT Gene

Domains & Families for TFPT Gene

Gene Families for TFPT Gene

Protein Domains for TFPT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TFPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TFPT: view

No data available for UniProtKB/Swiss-Prot for TFPT Gene

Function for TFPT Gene

Molecular function for TFPT Gene

UniProtKB/Swiss-Prot Function:
Appears to promote apoptosis in a p53/TP53-independent manner.
UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Ontology (GO) - Molecular Function for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 17395368
genes like me logo Genes that share ontologies with TFPT: view
genes like me logo Genes that share phenotypes with TFPT: view

Animal Model Products

miRNA for TFPT Gene

miRTarBase miRNAs that target TFPT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFPT Gene

Localization for TFPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFPT Gene COMPARTMENTS Subcellular localization image for TFPT gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm ISS --
GO:0031011 Ino80 complex IDA 21303910
genes like me logo Genes that share ontologies with TFPT: view

Pathways & Interactions for TFPT Gene

genes like me logo Genes that share pathways with TFPT: view

Gene Ontology (GO) - Biological Process for TFPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TFPT: view

No data available for SIGNOR curated interactions for TFPT Gene

Drugs & Compounds for TFPT Gene

(10) Drugs for TFPT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for TFPT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFPT: view

Transcripts for TFPT Gene

Unigene Clusters for TFPT Gene

TCF3 (E2A) fusion partner (in childhood Leukemia):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFPT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TFPT Gene

GeneLoc Exon Structure for
TFPT
ECgene alternative splicing isoforms for
TFPT

Expression for TFPT Gene

mRNA expression in normal human tissues for TFPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFPT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5), Placenta (19.0), Blymphocyte (10.7), CD8 Tcells (8.2), and NK cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFPT Gene



Protein tissue co-expression partners for TFPT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TFPT Gene:

TFPT

SOURCE GeneReport for Unigene cluster for TFPT Gene:

Hs.590939
genes like me logo Genes that share expression patterns with TFPT: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TFPT Gene

Orthologs for TFPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFPT 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia TFPT 34 35
  • 89.24 (n)
dog
(Canis familiaris)
Mammalia TFPT 34 35
  • 88.54 (n)
mouse
(Mus musculus)
Mammalia Tfpt 34 16 35
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia Tfpt 34
  • 87.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TFPT 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFPT 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFPT 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfpt 34
  • 61.3 (n)
Str.20229 34
zebrafish
(Danio rerio)
Actinopterygii TFPT 35
  • 47 (a)
OneToOne
Species where no ortholog for TFPT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFPT Gene

ENSEMBL:
Gene Tree for TFPT (if available)
TreeFam:
Gene Tree for TFPT (if available)

Paralogs for TFPT Gene

No data available for Paralogs for TFPT Gene

Variants for TFPT Gene

Sequence variations from dbSNP and Humsavar for TFPT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs878959857 -- 54,106,715(+) GGGGT(C/T)CCCCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs879134447 -- 54,109,960(+) GAGGG(G/T)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFPT Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718853 CNV deletion 23290073
esv2718854 CNV deletion 23290073
esv3893246 CNV gain 25118596
nsv1056177 CNV gain 25217958
nsv470157 CNV loss 18288195
nsv510773 CNV deletion 20534489
nsv515623 CNV loss 19592680
nsv833877 CNV loss 17160897
nsv953613 CNV deletion 24416366

Variation tolerance for TFPT Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFPT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPT Gene

Disorders for TFPT Gene

MalaCards: The human disease database

(1) MalaCards diseases for TFPT Gene - From: GeneCards

Disorder Aliases PubMed IDs
childhood leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TFPT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TFPT_HUMAN
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3. {ECO:0000269 PubMed:10086727}.

Relevant External Links for TFPT

Genetic Association Database (GAD)
TFPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFPT
genes like me logo Genes that share disorders with TFPT: view

No data available for Genatlas for TFPT Gene

Publications for TFPT Gene

  1. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PMID: 17041757) Franchini C. … Privitera E. (Apoptosis 2006) 3 4 22 64
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4 64
  3. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PMID: 10086727) Brambillasca F. … Privitera E. (Leukemia 1999) 3 4 22 64
  4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4 64
  5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4 64

Products for TFPT Gene

Sources for TFPT Gene

Content
Loading form....