Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TFPT Gene

protein-coding   GIFtS: 51
GCID: GC19M054610

TCF3 (E2A) Fusion Partner (In Childhood Leukemia)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TCF3 (E2A) Fusion Partner (In Childhood Leukemia)1 2     FB12
INO80 Complex Subunit F1 2 3     Amida, Partner Of The E2A2
amida1 2     TCF3 Fusion Partner2
INO80F2 3     Protein FB13
Partner Of The E2A1     

External Ids:    HGNC: 136301   Entrez Gene: 298442   Ensembl: ENSG000001056197   OMIM: 6095195   UniProtKB: P0C1Z63   

Export aliases for TFPT gene to outside databases

Previous GC identifers: GC19M055256 GC19M055034 GC19M059286 GC19M059302 GC19M050926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TFPT Gene:
TFPT (TCF3 (E2A) fusion partner (in childhood Leukemia)) is a protein-coding gene. Diseases associated with TFPT include childhood leukemia, and differentiating neuroblastoma. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
Function: Appears to promote apoptosis in a p53/TP53-independent manner
Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
transcriptional regulation, DNA replication and probably DNA repair

Gene Wiki entry for TFPT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NT_187693.1  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFPT gene promoter:
         TBP   Pax-2   Pax-2a   Egr-4   C/EBPalpha   AREB6   PPAR-gamma1   COMP1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFPT promoter sequence
   Search Chromatin IP Primers for TFPT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13

TFPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054610:  view genomic region     (about GC identifiers)

Start:
54,610,320 bp from pter      End:
54,619,055 bp from pter
Size:
8,736 bases      Orientation:
minus strand

Selected alternative locations (see all 8):
Chr19-,NW_003571057 81,433-90,168      Chr19-,NW_003571058 81,433-90,168      Chr19-,NW_003571056 81,433-90,168     
Chr19-,NW_003571055 81,433-90,168      Chr19-,NW_003571060 81,433-90,168      Chr19-,NW_003571061 81,433-90,168     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6 (See protein sequence)
Recommended Name: TCF3 fusion partner  
Size: 253 amino acids; 28278 Da
Subunit: Interacts with NOL3 (By similarity). Component of the chromatin remodeling INO80 complex; specifically
part of a complex module associated with the N-terminus of INO80

Explore the universe of human proteins at neXtProt for TFPT: NX_P0C1Z6

Explore proteomics data for TFPT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TFPT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037474.1  
    ENSEMBL proteins: 
     ENSP00000375639   ENSP00000375638   ENSP00000395180   ENSP00000375637  

    TFPT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TFPT
    GenScript Custom Purified and Recombinant Proteins Services for TFPT
    Novus Biologicals TFPT Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFPT

    TFPT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TFPT
    Novus Biologicals TFPT Antibody
    Abcam antibodies for TFPT
    Cloud-Clone Corp. Antibodies for TFPT
    ThermoFisher Antibodies for TFPT
    LSBio Antibodies in human, mouse, rat for TFPT

    TFPT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TFPT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TFPT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TFPT
    Cloud-Clone Corp. CLIAs for TFPT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    INO80: INO80 complex subunits

    ProtoNet protein and cluster: P0C1Z6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPT_HUMAN, P0C1Z6
    Function: Appears to promote apoptosis in a p53/TP53-independent manner
    Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
    transcriptional regulation, DNA replication and probably DNA repair

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI17395368
    GO:0019901protein kinase binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TFPT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TFPT:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFPT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFPT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFPT

    miRNA
    Products:
        
    miRTarBase miRNAs that target TFPT:
    hsa-mir-26b-5p (MIRT028955)

    Block miRNA regulation of human, mouse, rat TFPT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TFPT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TFPT
    Predesigned siRNA for gene silencing in human, mouse, rat TFPT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TFPT

    Clone
    Products:
         
    OriGene clones in human, mouse for TFPT (see all 7)
    OriGene ORF clones in mouse, rat for TFPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFPT (NM_013342)
    Sino Biological Human cDNA Clone for TFPT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TFPT
    Browse ESI BIO Cell Lines and PureStem Progenitors for TFPT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TFPT_HUMAN, P0C1Z6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005884actin filament IEA--
    GO:0031011Ino80 complex IDA--

    TFPT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFPT
    Interactions:

        GeneGlobe Interaction Network for TFPT

    Selected Interacting proteins for TFPT (P0C1Z61, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EAF2Q96CJ11, 3EBI-1245626,EBI-1245604 I2D: score=3 
    UCHL5Q9Y5K51, 3EBI-1245626,EBI-1051183 I2D: score=2 
    EAF1Q96JC93I2D: score=3 
    ELLP551993I2D: score=3 
    PAWRQ96IZ03I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process ----

    TFPT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFPT

    Selected Novoseek inferred chemical compound relationships for TFPT gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminopentol 93.5 8 9473533 (1), 9668088 (1), 8089434 (1), 10528731 (1) (see all 7)
    sphinganine 88.2 33 9473533 (4), 9668088 (2), 9892062 (2), 11223085 (1) (see all 14)
    tricarballylate 83.8 2 8914830 (1)
    sphingosine 80.6 23 11223085 (2), 10496371 (2), 9892062 (2), 9988695 (1) (see all 16)
    deoxynivalenol 79.2 42 16019124 (7), 14630058 (6), 17109910 (3), 16968296 (2) (see all 13)
    zearalenone 75.2 27 16019124 (7), 10560568 (3), 17109910 (3), 16019843 (2) (see all 9)
    ceramide 73.5 28 9668088 (3), 17030510 (2), 11815611 (2), 19937735 (2) (see all 18)
    moniliformin 70.9 18 11848570 (5), 11131899 (2), 14708984 (1)
    nivalenol 66.1 17 14630058 (6), 8612007 (2), 10560568 (2), 11955675 (1)
    o phthalaldehyde 65 4 8854911 (1), 9735014 (1), 7580311 (1)



    TFPT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TFPT gene: 
    NM_013342.3  

    Unigene Cluster for TFPT:

    TCF3 (E2A) fusion partner (in childhood Leukemia)
    Hs.590939  [show with all ESTs]
    Unigene Representative Sequence: BM810210
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391759(uc010yej.1 uc010erd.2) ENST00000391758 ENST00000420715
    ENST00000391757
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TFPT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TFPT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TFPT
    Predesigned siRNA for gene silencing in human, mouse, rat TFPT
    Clone
    Products:
         
    OriGene clones in human, mouse for TFPT (see all 7)
    OriGene ORF clones in mouse, rat for TFPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFPT (NM_013342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TFPT
    OriGene qSTAR qPCR primer pairs in human, mouse for TFPT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPT
      QuantiTect SYBR Green Assays in human, mouse, rat TFPT
      QuantiFast Probe-based Assays in human, mouse, rat TFPT

    Additional mRNA sequence: 

    AF052052.1 AK310627.1 AK310647.1 BC001728.1 BC004281.1 BC007776.2 

    10 DOTS entries:

    DT.447997  DT.110917  DT.97845460  DT.91734404  DT.100785299  DT.97833336  DT.100785303  DT.121451716 
    DT.440286  DT.92428332 

    Selected AceView cDNA sequences (see all 138):

    BE892562 BI822385 BM694332 BU183252 BQ772644 AI983968 BQ368294 BC004281 
    BG757617 CB150805 CF541358 BU687549 CB217569 BG763205 AI368240 BM712159 
    BQ670942 BQ017034 BM980160 CA748983 BQ066031 BU625886 BU160949 BE747349 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TFPT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -                                       
    SP2:                                      -                 -                     
    SP3:                                      -                                       
    SP4:                                      -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for TFPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TFPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAATAAAC
    TFPT Expression
    About this image


    TFPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    TFPT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFPT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590939
        Custom PCR Arrays for TFPT
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TFPT
    OriGene qSTAR qPCR primer pairs in human, mouse for TFPT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPT
    QuantiTect SYBR Green Assays in human, mouse, rat TFPT
    QuantiFast Probe-based Assays in human, mouse, rat TFPT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TFPT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpt1 , 5 TCF3 (E2A) fusion partner1, 5 87.28(n)1
    91.16(a)1
      7 (2.09 cM)5
    697141  NM_023524.11  NP_076013.11 
     36203245 
    lizard
    (Anolis carolinensis)
    Reptilia TFPT6
    TCF3 (E2A) fusion partner (in childhood Leukemia)
    60(a)
    1 ↔ 1
    GL343279.1(1538266-1541399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.202292 Transcribed sequence with weak similarity to protein more 76.29(n)    142014429 
    zebrafish
    (Danio rerio)
    Actinopterygii TFPT6
    TCF3 fusion partner homolog (tfpt), mRNA
    47(a)
    1 ↔ 1
    16(5477786-5484868) ENSDARG00000089572


    ENSEMBL Gene Tree for TFPT (if available)
    TreeFam Gene Tree for TFPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TFPT (see all 210)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2542641,2
    C,F,A,H--54610976(-) GAGTGC/GAAGGG 1 -- int1 trp317Minor allele frequency- G:0.48NS EA NA WA CSA 791
    rs775779611,2
    F--54610982(+) CACTCC/TGTCTT 1 -- int12Minor allele frequency- T:0.15CSA WA 119
    rs665060161,2
    C,F--54610983(+) ACTCCG/TTCTTC 1 -- int12Minor allele frequency- T:0.05CSA NA 121
    rs1850496601,2
    --54611111(+) TCCAAC/TTACTT 1 -- int10--------
    rs560618121,2
    C,F--54611131(+) ATCCTA/GGGCCT 1 -- int15Minor allele frequency- G:0.08CSA WA NA EA 361
    rs1464928651,2
    --54611217(+) AAGAGC/TCCTGA 1 -- int10--------
    rs1886602871,2
    --54611227(+) AACCTA/GACTCA 1 -- int10--------
    rs771471731,2
    C,F--54611283(+) ACTGGA/C/TGCCGG 1 -- int12WA NA 238
    rs6211491,2
    C--54611284(-) GCCGGC/TGCCAG 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs6211471,2
    C,F,A,H--54611287(-) AGAGCC/TGGCGC 1 -- int122Minor allele frequency- T:0.46NS EA NA WA CSA 2347

    HapMap Linkage Disequilibrium report for TFPT (54610320 - 54619055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TFPT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718854CNV Deletion23290073
    esv2718853CNV Deletion23290073
    esv2718812CNV Deletion23290073
    esv1362488CNV Insertion17803354
    nsv515623CNV Loss19592680
    nsv470157CNV Loss18288195
    nsv510773CNV Loss20534489
    nsv833877CNV Loss17160897
    dgv4001n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFPT
    DNA2.0 Custom Variant and Variant Library Synthesis for TFPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609519    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFPT_HUMAN, P0C1Z6
  • Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Inversion inv(19)(p13;q13) with TCF3

  • Selected diseases for TFPT (see all 22):    
    About MalaCards
    childhood leukemia    differentiating neuroblastoma    eaf    retinal disease
    neural tube defects    esophageal cancer    neuroblastoma    lung adenocarcinoma
    retinoblastoma    papilloma    leukemia    lymphoblastic leukemia
    retinitis    esophagitis    mental retardation    atherosclerosis
    adenocarcinoma    thyroiditis    obesity    multiple myeloma


    TFPT for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TFPT gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    animal diseases 64.2 5 1628862 (1), 9384738 (1), 10575354 (1), 9725030 (1) (see all 5)
    leukemogenesis 18.8 2 17041757 (2)
    edema 16.1 3 12153764 (1), 7582616 (1), 9719762 (1)
    tumors 2.6 3 8602837 (1), 14988222 (1), 8917690 (1)
    leukemia 0 6 17395368 (2), 11700047 (1)
    necrosis 0 4 16412405 (1), 11875625 (1), 9719762 (1), 14630058 (1)
    renal disease 0 1 8761355 (1)
    glioma 0 6 10739748 (1), 15297026 (1), 10839479 (1)
    glioblastoma 0 3 15621711 (2), 15337581 (1)
    carcinoma 0 1 15718252 (1)

    Genetic Association Database (GAD): TFPT

    Export disorders for TFPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TFPT gene, integrated from 10 sources (see all 174):
    (articles sorted by number of sources associating them with TFPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (J. Biol. Chem. 2005)
    2. Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced. (PubMed id 17041757)1, 2, 9 Franchini C.... Privitera E. (Apoptosis 2006)
    3. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)1, 2, 9 Brambillasca F.... Privitera E. (Leukemia 1999)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. (PubMed id 10644725)1, 3 Irie Y....Miki N. (J. Biol. Chem. 2000)
    9. FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. (PubMed id 17395368)1, 9 Jiang F....Wang Z. (Cancer Lett. 2007)
    10. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. (PubMed id 23684607)1 Andrysik Z....Espinosa J.M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29844 HGNC: 13630 AceView: TFPT Ensembl:ENSG00000105619 euGenes: HUgn29844
    ECgene: TFPT H-InvDB: TFPT

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TFPT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFPT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TFPT gene:
    Search GeneIP for patents involving TFPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TFPT  
     OriGene qPCR primer pairs and template standards for TFPT   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TFPT  
     OriGene qSTAR qPCR primer pairs in human, mouse for TFPT   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TFPT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TFPT   OriGene Custom Protein Services for TFPT  

     
     
     Block miRNA regulation of human, mouse, rat TFPT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TFPT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFPT Predesigned siRNA for gene silencing in human, mouse, rat TFPT
     QuantiFast Probe-based Assays in human, mouse, rat TFPT QuantiTect SYBR Green Assays in human, mouse, rat TFPT
     Custom PCR Arrays for TFPT Search Chromatin IP Primers for TFPT
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPT  GeneGlobe Interaction Network for TFPT
     Regulatory tfbs in TFPT promoter
     GenScript Custom Purified and Recombinant Proteins Services for TFPT GenScript cDNA clones with any tag delivered in your preferred vector for TFPT
     GenScript Custom Assay Services for TFPT GenScript Custom overexpressing Cell Line Services for TFPT
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TFPT
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TFPT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TFPT antibodies
     TFPT proteins
     Antibodies for TFPT
     See all of Abcam's Antibodies, Kits and Proteins for TFPT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TFPT
     Antibodies for TFPT
     ELISAs for TFPT
     CLIAs for TFPT



     Browse ESI BIO Cell Lines and PureStem Progenitors for TFPT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPT
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TFPT
     SwitchGear Promoter luciferase reporter plasmids for TFPT
     ThermoFisher Antibodies for TFPT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPT
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFPT
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFPT
     LSBio Antibodies in human, mouse, rat for TFPT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TFPT gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4