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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFPI2 Gene

protein-coding   GIFtS: 65
GCID: GC07M093514

Tissue Factor Pathway Inhibitor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tissue Factor Pathway Inhibitor 21 2
Placental Protein 52 3
PP52 3
TFPI-22 3
REF12
Retinal Pigment Epithelium Cell Factor 12

External Ids:    HGNC: 117611   Entrez Gene: 79802   Ensembl: ENSG000001058257   OMIM: 6000335   UniProtKB: P483073   

Export aliases for TFPI2 gene to outside databases

Previous GC identifers: GC07M092051 GC07M093113 GC07M093127 GC07M093159 GC07M093352 GC07M088123


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFPI2 Gene:
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a
variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and
plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for TFPI2 Gene: 
TFPI2 (tissue factor pathway inhibitor 2) is a protein-coding gene. Diseases associated with TFPI2 include amelanotic melanoma, and gestational trophoblastic neoplasm, and among its related super-pathways are Matrix Metalloproteinases and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include extracellular matrix structural constituent and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINT2.

UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin,
factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin

Gene Wiki entry for TFPI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFPI2 gene promoter:
         ER-alpha   Nkx3-1   STAT5B   Nkx3-1 v4   FOXD3   Nkx3-1 v1   POU3F2   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFPI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TFPI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q

TFPI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPI2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M093514:  view genomic region     (about GC identifiers)

Start:
93,514,709 bp from pter      End:
93,520,303 bp from pter
Size:
5,595 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 92,844,909-92,849,229     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307 (See protein sequence)
Recommended Name: Tissue factor pathway inhibitor 2 precursor  
Size: 235 amino acids; 26934 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for TFPI2:
1ZR0 (3D)    
Secondary accessions: Q66ME8 Q9UC86

Explore the universe of human proteins at neXtProt for TFPI2: NX_P48307

Explore proteomics data for TFPI2 at MOPED 

TFPI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TFPI2 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001257932.1  NP_001257933.1  NP_006519.1  

ENSEMBL proteins: 
 ENSP00000222543   ENSP00000416370   ENSP00000438861  

Human Recombinant Protein Products for TFPI2: 
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Sino Biological Cell Lysate for TFPI2 
ProSpec Recombinant Protein for TFPI2
Cloud-Clone Corp. Proteins for TFPI2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005578proteinaceous extracellular matrix TAS8914837

TFPI2 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TFPI2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR002223 Prot_inh_Kunz-m
 IPR008296 Prot_inhib_I2_TFPI
 IPR020901 Prtase_inh_Kunz-CS

Graphical View of Domain Structure for InterPro Entry P48307

ProtoNet protein and cluster: P48307

1 Blocks protein domain: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
Domain: This inhibitor contains three inhibitory domains
Similarity: Contains 3 BPTI/Kunitz inhibitor domains


TFPI2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFPI2_HUMAN, P48307
Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin,
factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin

     Genatlas biochemistry entry for TFPI2:
tissue factor pathway inhibitor 2,serine proteinase inhibitor (see TSG7B)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005201extracellular matrix structural constituent TAS8914837
GO:0030414peptidase inhibitor activity ----
     
TFPI2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TFPI2:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TFPI2 
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miRNA
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miRTarBase miRNAs that target TFPI2:
hsa-mir-616 (MIRT005774)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFPI2
4 QIAGEN miScript miRNA Assays for microRNAs that regulate TFPI2:
hsa-miR-548am hsa-miR-548x hsa-miR-3182 hsa-miR-646
SwitchGear 3'UTR luciferase reporter plasmidTFPI2 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TFPI2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Matrix Metalloproteinases
Inhibition of Matrix Metalloproteinases0.68
2Formation of Fibrin Clot (Clotting Cascade)
Blood Coagulation Signaling Pathways0.51
3Cell adhesion Plasmin signaling
Cell adhesion Plasmin signaling1.00

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TFPI2
    Cell adhesion Plasmin signaling

1 R&D Systems Pathway for TFPI2
    Blood Coagulation Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TFPI2
    Inhibition of Matrix Metalloproteinases

1 GeneGo (Thomson Reuters) Pathway for TFPI2
    Cell adhesion Plasmin signaling




TFPI2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFPI2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for TFPI2 (P483072, 3 ENSP000002225434) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SKILP127572, 3MINT-61681 I2D: score=3 
SMURF2Q9HAU42, 3MINT-61789 I2D: score=3 
F11P039513, ENSP000002646914I2D: score=1 STRING: ENSP00000264691
KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
PLGP007473, ENSP000003089384I2D: score=1 STRING: ENSP00000308938
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007596blood coagulation IEA--
GO:0010466negative regulation of peptidase activity ----

TFPI2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TFPI2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFPI2

8 Novoseek inferred chemical compound relationships for TFPI2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 74.9 117 7896752 (2), 16411383 (2), 10954721 (2), 14970225 (2) (see all 50)
mspi 69.4 15 12876637 (1), 11448060 (1), 10082661 (1), 10496984 (1) (see all 6)
matrigel 63.3 3 16773181 (1), 11297250 (1), 11027624 (1)
5-aza-2'deoxycytidine 59.3 10 12881707 (2), 20113832 (2), 17464989 (1), 12956419 (1) (see all 5)
heparin 29.3 4 11027624 (2), 8159751 (1), 19902129 (1)
arginine 14.8 1 18401718 (1)
p002 12.8 4 15685245 (1)
aspartate 0 4 11027624 (1)

Search CenterWatch for drugs/clinical trials and news about TFPI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TFPI2 gene (3 alternative transcripts): 
NM_001271003.1  NM_001271004.1  NM_006528.3  

Unigene Cluster for TFPI2:

Tissue factor pathway inhibitor 2
Hs.438231  [show with all ESTs]
Unigene Representative Sequence: NM_006528
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000222543(uc003umy.1 uc003umz.1 uc003una.1) ENST00000451238
ENST00000461482 ENST00000545378
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFPI2
4 QIAGEN miScript miRNA Assays for microRNAs that regulate TFPI2:
hsa-miR-548am hsa-miR-548x hsa-miR-3182 hsa-miR-646
SwitchGear 3'UTR luciferase reporter plasmidTFPI2 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: TFPI2 (NM_006528)
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFPI2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFPI2

Additional mRNA sequence: 

AK024817.1 AK075425.1 AK075427.1 AK092499.1 AK129833.1 AK313260.1 AY691946.1 BC005330.1 
BC034155.1 D29992.1 EF488667.1 L27624.1 

24/61 DOTS entries (see all 61):

DT.453488  DT.100885681  DT.95354359  DT.100885687  DT.92470041  DT.439956  DT.95354387  DT.100885722 
DT.121070595  DT.121070623  DT.100885715  DT.100885744  DT.121070525  DT.121070496  DT.121070547  DT.121070571 
DT.121070584  DT.100885730  DT.121070472  DT.91662007  DT.100885735  DT.121070507  DT.95354367  DT.121070574 

24/1199 AceView cDNA sequences (see all 1199):

CR623266 CR608970 CF128071 CR607266 CF126804 CR621115 CF130872 BG620963 
CR626074 CR621169 CR590890 AA346072 CF527736 CF128231 CR612745 CR597753 
CR606059 BG572628 CR609544 BG572708 CR621703 CR611954 AL551981 CR594133 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TFPI2 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:                                -           -                                       
SP2:                    -           -           -                                       
SP3:                                -                                                   
SP4:                                -           -     -                                 
SP5:                                -           -                                       


ECgene alternative splicing isoforms for TFPI2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TFPI2 expression in normal human tissues (normalized intensities)      TFPI2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCTTTTAAC
TFPI2 Expression
About this image


TFPI2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/11 selected tissues (see all 11) fully expand
 
 Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
         Umbilical cord blood-derived endothelial progenitor cells
         Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
         huvec   
 
 Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Human Preadipocyte-visceral (HPA-v)   
         omental adipose tissue   
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Umbilical cord blood-derived endothelial progenitor cells
         huvec   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         HyStem+TGFbeta3+GDF5-induced MEL2 cells

See TFPI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFPI2

SOURCE GeneReport for Unigene cluster: Hs.438231

UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
Tissue specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at
advanced pregnancy

    SABiosciences Expression via Pathway-Focused PCR Arrays including TFPI2: 
          Prostate Cancer in human mouse rat
          Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFPI2
In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TFPI2 gene from 6/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tfpi21 , 5 tissue factor pathway inhibitor 21, 5 67.76(n)1
57.48(a)1
  6 (1.81 cM)5
217891  NM_009364.31  NP_033390.11 
 39625955 
chicken
(Gallus gallus)
Aves TFPI21 tissue factor pathway inhibitor 2 60.35(n)
51.54(a)
  420561  XM_418662.3  XP_418662.2 
lizard
(Anolis carolinensis)
Reptilia TFPI26
--
(see all 5)
--
49(a)
37(a)
(see all 5)
1 ↔ 1
possible ortholog
(see all 5)
6(21937306-21948600)
GL343322.1(846319-850984)
African clawed frog
(Xenopus laevis)
Amphibia BC055972.12   -- 73.76(n)    BC055972.1 
zebrafish
(Danio rerio)
Actinopterygii tfpi21 tissue factor pathway inhibitor 2 52.06(n)
43.81(a)
  560339  NM_001040096.2  NP_001035185.1 
worm
(Caenorhabditis elegans)
Secernentea F22E12.16
mec-16
Protein MEC-1, isoform e
6(a)
3(a)
many ↔ many
many ↔ many
V(10453866-10457347)
V(6956537-6966422)


ENSEMBL Gene Tree for TFPI2 (if available)
TreeFam Gene Tree for TFPI2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TFPI2 gene
SPINT22  WFIKKN22  AMBP2  SPINT32  SPINT12  WFIKKN12  TFPI2  
13 SIMAP similar genes for TFPI2 using alignment to 5 protein entries:     TFPI2_HUMAN (see all proteins):
EPPIN    COL28A1    SPINT3    COL6A3    WFIKKN2    PAPLN
SPINT2    TFPI    APLP2    SPINT4    AMBP    APP
WFDC8

TFPI2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/213 SNPs in TFPI2 are shown (see all 213)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs356832201,2
C--93517977(+) AGAAG-/AAAAAA 3 -- int12Minor allele frequency- A:0.25NA 4
rs58858511,2
C--93518691(+) TTTAC-/TTTTTT 3 -- int1 trp30--------
rs572826911,2
C--93521669(+) TTTTT-/TAATAC 3 -- us2k10--------
rs750283981,2
C,F--96820770(+) TTTTTG/TATAGA 3 -- ds50011Minor allele frequency- T:0.03EA 120
rs1894256021,2
--96820856(+) TGTATA/CCTTGT 3 -- ds50010--------
rs1814763271,2
--96820907(+) GAAATA/GTAACT 3 -- ds50010--------
rs1391174881,2
--96821191(+) AGTCAC/TTGAAA 3 -- ds50010--------
rs349144951,2
C,F,H--96821205(+) AGTATA/GTATCT 3 -- ds500116Minor allele frequency- G:0.06NS EA NA 1998
rs1871289961,2
--96821318(+) TTACAC/TGGTCC 3 -- ut310--------
rs734123371,2
C--96821351(+) TATATT/ATACAC 3 -- ut313Minor allele frequency- A:0.11WA EA 240

HapMap Linkage Disequilibrium report for TFPI2 (93514709 - 93520303 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TFPI2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv888738CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600033    OMIM disorders: --

20/39 diseases for TFPI2 (see all 39):    About MalaCards
amelanotic melanoma    gestational trophoblastic neoplasm    trophoblastic neoplasm    fibrosarcoma
placental abruption    choriocarcinoma    pancreatic ductal adenocarcinoma    laryngeal squamous cell carcinoma
glioblastoma    retinitis    esophagitis    laryngitis
gingivitis    esophageal squamous cell carcinoma    atherosclerosis    hepatocellular carcinoma
pancreatic cancer    nasopharyngitis    pancreatitis    squamous cell carcinoma

1 disease from the University of Copenhagen DISEASES database for TFPI2:
Cancer

TFPI2 for disorders           About GeneDecksing

10/20 Novoseek inferred disease relationships for TFPI2 gene (see all 20)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosarcoma 52.7 10 18401718 (2), 11027624 (2), 14525759 (2), 12632077 (1) (see all 5)
glioblastoma 49.6 16 17575213 (4), 11297250 (3), 12881707 (2), 15723303 (2)
choriocarcinoma 45.2 4 12956419 (2), 12757776 (1), 20031192 (1)
tumors 38.5 84 18000791 (5), 20377370 (4), 14525759 (4), 17352822 (4) (see all 32)
glioma 37.9 42 11840337 (5), 11297250 (5), 12738994 (5), 11687973 (4) (see all 7)
metastasis 35.6 35 14525759 (4), 20377370 (3), 18000791 (2), 11315097 (2) (see all 16)
atherosclerotic plaque 34.2 12 19081094 (3), 11342575 (2), 16039658 (2)
brain tumors 29 4 12881707 (1), 16773181 (1), 11687973 (1)
nsclc 18.6 11 15685245 (4), 17208328 (1), 19267203 (1)
cancer 18.4 32 15735751 (6), 18000791 (3), 7896752 (1), 15685245 (1) (see all 12)

Genetic Association Database (GAD): TFPI2
Human Genome Epidemiology (HuGE) Navigator: TFPI2 (3 documents)

Export disorders for TFPI2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TFPI2 gene, integrated from 9 sources (see all 154):
(articles sorted by number of sources associating them with TFPI2)
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  1. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. (PubMed id 7896752)1, 2, 3, 9 Miyagi Y.... Miyazaki K. (1994)
  2. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. (PubMed id 8159751)1, 2, 9 Sprecher C.A.... Foster D.C. (1994)
  3. Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors. (PubMed id 16247609)1, 4, 9 Siegling S....Gotting C. (2006)
  4. Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer. (PubMed id 17208328)1, 4, 9 Rollin J....Gruel Y. (2007)
  5. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. (PubMed id 11342222)1, 2, 9 Kamei S.... Kisiel W. (2001)
  6. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. (PubMed id 8945635)1, 3, 9 Miyagi Y....Miyazaki K. (1996)
  7. Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition. (PubMed id 15932872)1, 2 Schmidt A.E.... Bajaj S.P. (2005)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7980 HGNC: 11761 AceView: TFPI2 Ensembl:ENSG00000105825 euGenes: HUgn7980
ECgene: TFPI2 H-InvDB: TFPI2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TFPI2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFPI2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TFPI2 gene:
Search GeneIP for patents involving TFPI2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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