Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TFPI2 Gene

Aliases for TFPI2 Gene

  • Tissue Factor Pathway Inhibitor 2 2 3
  • Placental Protein 5 3 4
  • TFPI-2 3 4
  • PP5 3 4
  • Retinal Pigment Epithelium Cell Factor 1 3
  • REF1 3

External Ids for TFPI2 Gene

Previous GeneCards Identifiers for TFPI2 Gene

  • GC07M092051
  • GC07M093113
  • GC07M093127
  • GC07M093159
  • GC07M093352
  • GC07M093514
  • GC07M088123

Summaries for TFPI2 Gene

Entrez Gene Summary for TFPI2 Gene

  • This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for TFPI2 Gene

TFPI2 (Tissue Factor Pathway Inhibitor 2) is a Protein Coding gene. Diseases associated with TFPI2 include amelanotic melanoma and fibrosarcoma. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and extracellular matrix structural constituent. An important paralog of this gene is TFPI.

UniProtKB/Swiss-Prot for TFPI2 Gene

  • May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Gene Wiki entry for TFPI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPI2 Gene

Genomics for TFPI2 Gene

Regulatory Elements for TFPI2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TFPI2 Gene

93,885,397 bp from pter
93,890,991 bp from pter
5,595 bases
Minus strand

Genomic View for TFPI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFPI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPI2 Gene

Proteins for TFPI2 Gene

  • Protein details for TFPI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tissue factor pathway inhibitor 2
    Protein Accession:
    Secondary Accessions:
    • Q66ME8
    • Q8NAK6
    • Q9UC86

    Protein attributes for TFPI2 Gene

    235 amino acids
    Molecular mass:
    26934 Da
    Quaternary structure:
    • Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

    Three dimensional structures from OCA and Proteopedia for TFPI2 Gene

    Alternative splice isoforms for TFPI2 Gene


neXtProt entry for TFPI2 Gene

Proteomics data for TFPI2 Gene at MOPED

Post-translational modifications for TFPI2 Gene

  • Glycosylation at Asn116 and Asn170
  • Modification sites at PhosphoSitePlus

Other Protein References for TFPI2 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for TFPI2 Gene

Domains for TFPI2 Gene

Protein Domains for TFPI2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P48307
  • This inhibitor contains three inhibitory domains
  • Contains 3 BPTI/Kunitz inhibitor domains.
genes like me logo Genes that share domains with TFPI2: view

No data available for Gene Families for TFPI2 Gene

Function for TFPI2 Gene

Molecular function for TFPI2 Gene

GENATLAS Biochemistry: tissue factor pathway inhibitor 2,serine proteinase inhibitor (see TSG7B)
UniProtKB/Swiss-Prot Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Gene Ontology (GO) - Molecular Function for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005201 extracellular matrix structural constituent TAS 8914837
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with TFPI2: view

Phenotypes for TFPI2 Gene

GenomeRNAi human phenotypes for TFPI2:
genes like me logo Genes that share phenotypes with TFPI2: view

Animal Model Products

CRISPR Products

miRNA for TFPI2 Gene

miRTarBase miRNAs that target TFPI2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TFPI2 Gene

Localization for TFPI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPI2 Gene


Subcellular locations from

Jensen Localization Image for TFPI2 Gene COMPARTMENTS Subcellular localization image for TFPI2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix TAS 8914837
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TFPI2: view

Pathways for TFPI2 Gene

genes like me logo Genes that share pathways with TFPI2: view

Pathways by source for TFPI2 Gene

1 Qiagen pathway for TFPI2 Gene
1 GeneGo (Thomson Reuters) pathway for TFPI2 Gene
1 R&D Systems pathway for TFPI2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0010466 negative regulation of peptidase activity --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with TFPI2: view

Compounds for TFPI2 Gene

(8) Novoseek inferred chemical compound relationships for TFPI2 Gene

Compound -log(P) Hits PubMed IDs
serine 74.9 55
mspi 69.4 6
matrigel 63.3 3
5-aza-2deoxycytidine 59.3 7
heparin 29.3 4
genes like me logo Genes that share compounds with TFPI2: view

Transcripts for TFPI2 Gene

Unigene Clusters for TFPI2 Gene

Tissue factor pathway inhibitor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFPI2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFPI2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TFPI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFPI2 Gene

mRNA expression in normal human tissues for TFPI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFPI2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFPI2 Gene

SOURCE GeneReport for Unigene cluster for TFPI2 Gene Hs.438231

mRNA Expression by UniProt/SwissProt for TFPI2 Gene

Tissue specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy
genes like me logo Genes that share expressions with TFPI2: view

In Situ Assay Products

Orthologs for TFPI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFPI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TFPI2 35
  • 99.43 (n)
  • 99.57 (a)
TFPI2 36
  • 100 (a)
(Bos Taurus)
Mammalia TFPI2 35
  • 80.46 (n)
  • 71.98 (a)
TFPI2 36
  • 73 (a)
(Canis familiaris)
Mammalia TFPI2 35
  • 80.52 (n)
  • 70.56 (a)
TFPI2 36
  • 70 (a)
(Mus musculus)
Mammalia Tfpi2 35
  • 67.99 (n)
  • 57.71 (a)
Tfpi2 16
Tfpi2 36
  • 53 (a)
(Monodelphis domestica)
Mammalia ELP 36
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia TFPI2 36
  • 42 (a)
(Rattus norvegicus)
Mammalia Tfpi2 35
  • 68.33 (n)
  • 57.71 (a)
(Gallus gallus)
Aves TFPI2 35
  • 63.72 (n)
  • 55.8 (a)
TFPI2 36
  • 45 (a)
(Anolis carolinensis)
Reptilia TFPI2 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tfpi2 35
  • 62.07 (n)
  • 57.47 (a)
(Danio rerio)
Actinopterygii tfpi2 35
  • 52.89 (n)
  • 45.25 (a)
tfpi2 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F22E12.1 36
  • 6 (a)
mec-1 36
  • 3 (a)
mec-9 36
  • 8 (a)
ZK287.4 36
  • 5 (a)
Species with no ortholog for TFPI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFPI2 Gene

Gene Tree for TFPI2 (if available)
Gene Tree for TFPI2 (if available)

Paralogs for TFPI2 Gene

Paralogs for TFPI2 Gene

Selected SIMAP similar genes for TFPI2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TFPI2: view

Variants for TFPI2 Gene

Sequence variations from dbSNP and Humsavar for TFPI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4264 -- 93,886,765(-) TGGTT(A/G)TATCT utr-variant-3-prime
rs4271 -- 93,885,943(-) GTCAT(A/T)CCAAT utr-variant-3-prime
rs4517 -- 93,886,681(-) TTTTT(A/C)AAAAA utr-variant-3-prime
rs13258 -- 93,886,045(+) AAACA(A/G)TATAA utr-variant-3-prime
rs1024388 -- 93,887,780(-) ACTAC(C/G)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFPI2 Gene

Variant ID Type Subtype PubMed ID
nsv888738 CNV Loss 21882294

Relevant External Links for TFPI2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPI2 Gene

Disorders for TFPI2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TFPI2 Gene including...

Search for TFPI2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TFPI2 Gene

(20) Novoseek inferred disease relationships for TFPI2 Gene

Disease -log(P) Hits PubMed IDs
fibrosarcoma 52.7 8
glioblastoma 49.6 11
choriocarcinoma 45.2 4
tumors 38.5 57
glioma 37.9 27

Relevant External Links for TFPI2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TFPI2: view

No data available for UniProtKB/Swiss-Prot for TFPI2 Gene

Publications for TFPI2 Gene

  1. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. (PMID: 7896752) Miyagi Y. … Miyazaki K. (J. Biochem. 1994) 2 3 4 23
  2. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. (PMID: 8159751) Sprecher C.A. … Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  3. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. (PMID: 8945635) Miyagi Y. … Miyazaki K. (DNA Cell Biol. 1996) 2 3 23
  4. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. (PMID: 11342222) Kamei S. … Kisiel W. (Biochim. Biophys. Acta 2001) 3 4 23
  5. Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors. (PMID: 16247609) Siegling S. … GAPtting C. (Ann. Hematol. 2006) 3 23 48

Products for TFPI2 Gene

Sources for TFPI2 Gene

Back to Top