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TFPI2 Gene

protein-coding   GIFtS: 65
GCID: GC07M093514

Tissue Factor Pathway Inhibitor 2

  See TFPI2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tissue Factor Pathway Inhibitor 21 2
Placental Protein 52 3
PP52 3
TFPI-22 3
REF12
Retinal Pigment Epithelium Cell Factor 12

External Ids:    HGNC: 117611   Entrez Gene: 79802   Ensembl: ENSG000001058257   OMIM: 6000335   UniProtKB: P483073   

Export aliases for TFPI2 gene to outside databases

Previous GC identifers: GC07M092051 GC07M093113 GC07M093127 GC07M093159 GC07M093352 GC07M088123


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFPI2 Gene:
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a
variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and
plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for TFPI2 Gene:
TFPI2 (tissue factor pathway inhibitor 2) is a protein-coding gene. Diseases associated with TFPI2 include amelanotic melanoma, and fibrosarcoma. GO annotations related to this gene include extracellular matrix structural constituent and serine-type endopeptidase inhibitor activity. An important paralog of this gene is WFIKKN2.

UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin,
factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin

Gene Wiki entry for TFPI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFPI2 gene promoter:
         ER-alpha   Nkx3-1   STAT5B   Nkx3-1 v4   FOXD3   Nkx3-1 v1   POU3F2   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFPI2 promoter sequence
   Search Chromatin IP Primers for TFPI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFPI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q

TFPI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPI2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M093514:  view genomic region     (about GC identifiers)

Start:
93,514,709 bp from pter      End:
93,520,303 bp from pter
Size:
5,595 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 92,844,909-92,849,229     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307 (See protein sequence)
Recommended Name: Tissue factor pathway inhibitor 2 precursor  
Size: 235 amino acids; 26934 Da
1 PDB 3D structure from and Proteopedia for TFPI2:
1ZR0 (3D)    
Secondary accessions: Q66ME8 Q9UC86

Explore the universe of human proteins at neXtProt for TFPI2: NX_P48307

Explore proteomics data for TFPI2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn116, Asn170

  • See TFPI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257932.1  NP_001257933.1  NP_006519.1  

    ENSEMBL proteins: 
     ENSP00000222543   ENSP00000416370   ENSP00000438861  

    TFPI2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TFPI2

     
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    Search eBioscience for ELISAs for TFPI2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002223 Prot_inh_Kunz-m
     IPR008296 Prot_inhib_I2_TFPI
     IPR020901 Prtase_inh_Kunz-CS

    Graphical View of Domain Structure for InterPro Entry P48307

    ProtoNet protein and cluster: P48307

    1 Blocks protein domain: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

    UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
    Domain: This inhibitor contains three inhibitory domains
    Similarity: Contains 3 BPTI/Kunitz inhibitor domains


    Find genes that share domains with TFPI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPI2_HUMAN, P48307
    Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin,
    factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin

         Genatlas biochemistry entry for TFPI2:
    tissue factor pathway inhibitor 2,serine proteinase inhibitor (see TSG7B)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005201extracellular matrix structural constituent TAS8914837
    GO:0030414peptidase inhibitor activity ----
         
    Find genes that share ontologies with TFPI2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TFPI2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFPI2
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    hsa-mir-616-3p (MIRT005774)

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    hsa-miR-548am hsa-miR-548x hsa-miR-3182 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTFPI2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFPI2_HUMAN, P48307: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix TAS8914837
    GO:0005634nucleus IDA--

    Find genes that share ontologies with TFPI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TFPI2 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Inhibition of Matrix Metalloproteinases0.68
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    3Cell adhesion Plasmin signaling
    Cell adhesion Plasmin signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TFPI2
        Blood Coagulation Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TFPI2
        Inhibition of Matrix Metalloproteinases

    1 GeneGo (Thomson Reuters) Pathway for TFPI2
        Cell adhesion Plasmin signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including TFPI2: 
              Prostate Cancer in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TFPI2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TFPI2 (P483072, 3 ENSP000002225434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61681 I2D: score=3 
    SMURF2Q9HAU42, 3MINT-61789 I2D: score=3 
    F11P039513, ENSP000002646914I2D: score=1 STRING: ENSP00000264691
    KLKB1P039523, ENSP000002646904I2D: score=1 STRING: ENSP00000264690
    PLGP007473, ENSP000003089384I2D: score=1 STRING: ENSP00000308938
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation IEA--
    GO:0010466negative regulation of peptidase activity ----

    Find genes that share ontologies with TFPI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFPI2

    8 Novoseek inferred chemical compound relationships for TFPI2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.9 117 7896752 (2), 16411383 (2), 10954721 (2), 14970225 (2) (see all 50)
    mspi 69.4 15 12876637 (1), 11448060 (1), 10082661 (1), 10496984 (1) (see all 6)
    matrigel 63.3 3 16773181 (1), 11297250 (1), 11027624 (1)
    5-aza-2'deoxycytidine 59.3 10 12881707 (2), 20113832 (2), 17464989 (1), 12956419 (1) (see all 5)
    heparin 29.3 4 11027624 (2), 8159751 (1), 19902129 (1)
    arginine 14.8 1 18401718 (1)
    p002 12.8 4 15685245 (1)
    aspartate 0 4 11027624 (1)



    Find genes that share compounds with TFPI2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TFPI2 gene (3 alternative transcripts): 
    NM_001271003.1  NM_001271004.1  NM_006528.3  

    Unigene Cluster for TFPI2:

    Tissue factor pathway inhibitor 2
    Hs.438231  [show with all ESTs]
    Unigene Representative Sequence: NM_006528
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222543(uc003umy.1 uc003umz.1 uc003una.1) ENST00000451238
    ENST00000461482 ENST00000545378
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TFPI2:
    hsa-miR-548am hsa-miR-548x hsa-miR-3182 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTFPI2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TFPI2
      QuantiFast Probe-based Assays in human, mouse, rat TFPI2

    Additional mRNA sequence: 

    AK024817.1 AK075425.1 AK075427.1 AK092499.1 AK129833.1 AK313260.1 AY691946.1 BC005330.1 
    BC034155.1 D29992.1 EF488667.1 L27624.1 

    Selected DOTS entries (see all 61):

    DT.453488  DT.100885681  DT.95354359  DT.100885687  DT.92470041  DT.439956  DT.95354387  DT.100885722 
    DT.121070595  DT.121070623  DT.100885715  DT.100885744  DT.121070525  DT.121070496  DT.121070547  DT.121070571 
    DT.121070584  DT.100885730  DT.121070472  DT.91662007  DT.100885735  DT.121070507  DT.95354367  DT.121070574 

    Selected AceView cDNA sequences (see all 1199):

    CR608257 BG623024 CD743195 CR617656 NM_006528 CR615468 CF128375 AL571240 
    CR619951 CR599490 BM557329 CR619096 CR603147 CR623265 CR621839 BG621785 
    CR619294 CF128041 BP374243 CA487196 CF126194 AL551821 CR619864 BM759691 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TFPI2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                -           -                                       
    SP2:                    -           -           -                                       
    SP3:                                -                                                   
    SP4:                                -           -     -                                 
    SP5:                                -           -                                       


    ECgene alternative splicing isoforms for TFPI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFPI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTTAAC
    TFPI2 Expression
    About this image


    TFPI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    TFPI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFPI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438231

    UniProtKB/Swiss-Prot: TFPI2_HUMAN, P48307
    Tissue specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at
    advanced pregnancy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TFPI2: 
              Prostate Cancer in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for TFPI2
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    QuantiFast Probe-based Assays in human, mouse, rat TFPI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFPI2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpi21 , 5 tissue factor pathway inhibitor 21, 5 67.99(n)1
    57.71(a)1
      6 (1.81 cM)5
    217891  NM_009364.31  NP_033390.11 
     39625895 
    chicken
    (Gallus gallus)
    Aves TFPI21 tissue factor pathway inhibitor 2 63.72(n)
    55.8(a)
      420561  XM_418662.4  XP_418662.2 
    lizard
    (Anolis carolinensis)
    Reptilia TFPI26
    tissue factor pathway inhibitor 2
    48(a)
    1 ↔ 1
    6(21937306-21948600)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC055972.12   -- 73.76(n)    BC055972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tfpi21 tissue factor pathway inhibitor 2 52.89(n)
    45.25(a)
      560339  NM_001040096.2  NP_001035185.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mec-96
    F22E12.16
    (see all 4)
    Protein F22E12.1 (F22E12.1) mRNA, complete cds
    (see all 4)
    8(a)
    6(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(9907632-9915087) WBGene00003173
    V(10453866-10457347) WBGene00009058


    ENSEMBL Gene Tree for TFPI2 (if available)
    TreeFam Gene Tree for TFPI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFPI2 gene
    WFIKKN22  AMBP2  SPINT32  WFIKKN12  TFPI2  
    13 SIMAP similar genes for TFPI2 using alignment to 5 protein entries:     TFPI2_HUMAN (see all proteins):
    EPPIN    AMBP    COL28A1    SPINT3    COL6A3    WFIKKN2
    PAPLN    SPINT2    TFPI    APLP2    SPINT4    APP
    WFDC8

    Find genes that share paralogs with TFPI2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFPI2 (see all 213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356832201,2
    C--93517977(+) AGAAG-/AAAAAA 3 -- int12Minor allele frequency- A:0.25NA 4
    rs58858511,2
    C--93518691(+) TTTAC-/TTTTTT 3 -- int1 trp30--------
    rs572826911,2
    C--93521669(+) TTTTT-/TAATAC 3 -- us2k10--------
    rs750283981,2
    C,F--96820770(+) TTTTTG/TATAGA 3 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1894256021,2
    --96820856(+) TGTATA/CCTTGT 3 -- ds50010--------
    rs1814763271,2
    --96820907(+) GAAATA/GTAACT 3 -- ds50010--------
    rs1391174881,2
    --96821191(+) AGTCAC/TTGAAA 3 -- ds50010--------
    rs349144951,2
    C,F,H--96821205(+) AGTATA/GTATCT 3 -- ds500116Minor allele frequency- G:0.06NS EA NA 1998
    rs1871289961,2
    --96821318(+) TTACAC/TGGTCC 3 -- ut310--------
    rs734123371,2
    C--96821351(+) TATATT/ATACAC 3 -- ut313Minor allele frequency- A:0.11WA EA 240

    HapMap Linkage Disequilibrium report for TFPI2 (93514709 - 93520303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TFPI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888738CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600033    OMIM disorders: --

    2 diseases for TFPI2:    
    About MalaCards
    amelanotic melanoma    fibrosarcoma

    1 disease from the University of Copenhagen DISEASES database for TFPI2:
    Cancer

    Find genes that share disorders with TFPI2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TFPI2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 52.7 10 18401718 (2), 11027624 (2), 14525759 (2), 12632077 (1) (see all 5)
    glioblastoma 49.6 16 17575213 (4), 11297250 (3), 12881707 (2), 15723303 (2)
    choriocarcinoma 45.2 4 12956419 (2), 12757776 (1), 20031192 (1)
    tumors 38.5 84 18000791 (5), 20377370 (4), 14525759 (4), 17352822 (4) (see all 32)
    glioma 37.9 42 11840337 (5), 11297250 (5), 12738994 (5), 11687973 (4) (see all 7)
    metastasis 35.6 35 14525759 (4), 20377370 (3), 18000791 (2), 11315097 (2) (see all 16)
    atherosclerotic plaque 34.2 12 19081094 (3), 11342575 (2), 16039658 (2)
    brain tumors 29 4 12881707 (1), 16773181 (1), 11687973 (1)
    nsclc 18.6 11 15685245 (4), 17208328 (1), 19267203 (1)
    cancer 18.4 32 15735751 (6), 18000791 (3), 7896752 (1), 15685245 (1) (see all 12)

    Genetic Association Database (GAD): TFPI2
    Human Genome Epidemiology (HuGE) Navigator: TFPI2 (3 documents)

    Export disorders for TFPI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFPI2 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with TFPI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. (PubMed id 7896752)1, 2, 3, 9 Miyagi Y.... Miyazaki K. (J. Biochem. 1994)
    2. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. (PubMed id 8159751)1, 2, 9 Sprecher C.A.... Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors. (PubMed id 16247609)1, 4, 9 Siegling S....GAPtting C. (Ann. Hematol. 2006)
    4. Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer. (PubMed id 17208328)1, 4, 9 Rollin J....Gruel Y. (Lung Cancer 2007)
    5. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. (PubMed id 11342222)1, 2, 9 Kamei S.... Kisiel W. (Biochim. Biophys. Acta 2001)
    6. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. (PubMed id 8945635)1, 3, 9 Miyagi Y....Miyazaki K. (DNA Cell Biol. 1996)
    7. Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition. (PubMed id 15932872)1, 2 Schmidt A.E.... Bajaj S.P. (J. Biol. Chem. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7980 HGNC: 11761 AceView: TFPI2 Ensembl:ENSG00000105825 euGenes: HUgn7980
    ECgene: TFPI2 H-InvDB: TFPI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFPI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFPI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFPI2 gene:
    Search GeneIP for patents involving TFPI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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