Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TFPI2 Gene

Aliases for TFPI2 Gene

  • Tissue Factor Pathway Inhibitor 2 2 3 5
  • Placental Protein 5 3 4
  • TFPI-2 3 4
  • PP5 3 4
  • Retinal Pigment Epithelium Cell Factor 1 3
  • REF1 3

External Ids for TFPI2 Gene

Previous GeneCards Identifiers for TFPI2 Gene

  • GC07M092051
  • GC07M093113
  • GC07M093127
  • GC07M093159
  • GC07M093352
  • GC07M093514
  • GC07M088123

Summaries for TFPI2 Gene

Entrez Gene Summary for TFPI2 Gene

  • This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for TFPI2 Gene

TFPI2 (Tissue Factor Pathway Inhibitor 2) is a Protein Coding gene. Diseases associated with TFPI2 include Malignant Ovarian Cyst and Fibrosarcoma. Among its related pathways are Matrix Metalloproteinases and Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is TFPI.

UniProtKB/Swiss-Prot for TFPI2 Gene

  • May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Gene Wiki entry for TFPI2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPI2 Gene

Genomics for TFPI2 Gene

Regulatory Elements for TFPI2 Gene

Enhancers for TFPI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G094055 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -166.2 -166245 2.8 JUN TEAD4 BACH1 MAX ZBTB40 ZNF316 SCRT2 FOS NFE2 MAFK BET1 GNG11 LOC105375401 TFPI2 ENSG00000236938 ENSG00000236453
GH07G094059 1.3 FANTOM5 ENCODE dbSUPER 11 -169.4 -169433 2.2 MTA2 CBFB ZBED1 NR2F1 CEBPB JUNB GABPA EED IKZF1 TCF7 BET1 GNG11 TFPI2 LOC105375401 ENSG00000236938 ENSG00000236453
GH07G093913 1.2 Ensembl ENCODE dbSUPER 11.5 -23.6 -23605 2.2 JUN RFX5 GATA3 ZNF316 GATA2 FOS TCF7L2 ELK4 CEBPB MAFG LOC105375401 TFPI2 GNG11 ENSG00000278388
GH07G093919 1.2 ENCODE dbSUPER 11 -31.2 -31188 4.5 PKNOX1 SIN3A GLI4 ZNF2 GLIS2 GATA2 KLF7 FOS REST SMARCB1 LOC105375401 TFPI2 GNG11 LOC105375402
GH07G094087 1.1 Ensembl ENCODE 10.6 -196.9 -196910 0.6 PKNOX1 SIN3A BMI1 ZNF2 RAD21 GATA2 ZNF143 RELB IKZF2 MIXL1 GNG11 LOC105375401 TFPI2 ENSG00000236938 GC07P094145
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TFPI2 on UCSC Golden Path with GeneCards custom track

Promoters for TFPI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215199 490 1400 KLF17 SIN3A RAD21 GLIS2 EGR1 ZNF366 SCRT2 FOS EGR2 ZNF654

Genomic Location for TFPI2 Gene

Chromosome:
7
Start:
93,885,397 bp from pter
End:
93,890,991 bp from pter
Size:
5,595 bases
Orientation:
Minus strand

Genomic View for TFPI2 Gene

Genes around TFPI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFPI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFPI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPI2 Gene

Proteins for TFPI2 Gene

  • Protein details for TFPI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48307-TFPI2_HUMAN
    Recommended name:
    Tissue factor pathway inhibitor 2
    Protein Accession:
    P48307
    Secondary Accessions:
    • Q66ME8
    • Q8NAK6
    • Q9UC86

    Protein attributes for TFPI2 Gene

    Size:
    235 amino acids
    Molecular mass:
    26934 Da
    Quaternary structure:
    • Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

    Three dimensional structures from OCA and Proteopedia for TFPI2 Gene

    Alternative splice isoforms for TFPI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFPI2 Gene

Post-translational modifications for TFPI2 Gene

  • Glycosylation at Asn116 and posLast=170170
  • Modification sites at PhosphoSitePlus

Other Protein References for TFPI2 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for TFPI2

No data available for DME Specific Peptides for TFPI2 Gene

Domains & Families for TFPI2 Gene

Protein Domains for TFPI2 Gene

Graphical View of Domain Structure for InterPro Entry

P48307

UniProtKB/Swiss-Prot:

TFPI2_HUMAN :
  • This inhibitor contains three inhibitory domains.
Domain:
  • This inhibitor contains three inhibitory domains.
genes like me logo Genes that share domains with TFPI2: view

No data available for Gene Families for TFPI2 Gene

Function for TFPI2 Gene

Molecular function for TFPI2 Gene

GENATLAS Biochemistry:
tissue factor pathway inhibitor 2,serine proteinase inhibitor (see TSG7B)
UniProtKB/Swiss-Prot Function:
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Gene Ontology (GO) - Molecular Function for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005201 extracellular matrix structural constituent TAS 8914837
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with TFPI2: view
genes like me logo Genes that share phenotypes with TFPI2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TFPI2

CRISPR Products

miRNA for TFPI2 Gene

miRTarBase miRNAs that target TFPI2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFPI2 Gene

Localization for TFPI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPI2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFPI2 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix TAS 8914837
GO:0031012 extracellular matrix IDA 23979707
genes like me logo Genes that share ontologies with TFPI2: view

Pathways & Interactions for TFPI2 Gene

genes like me logo Genes that share pathways with TFPI2: view

Pathways by source for TFPI2 Gene

1 GeneGo (Thomson Reuters) pathway for TFPI2 Gene
1 R&D Systems pathway for TFPI2 Gene
1 Qiagen pathway for TFPI2 Gene

Gene Ontology (GO) - Biological Process for TFPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0071498 cellular response to fluid shear stress IEA --
genes like me logo Genes that share ontologies with TFPI2: view

No data available for SIGNOR curated interactions for TFPI2 Gene

Drugs & Compounds for TFPI2 Gene

(3) Drugs for TFPI2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for TFPI2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFPI2: view

Transcripts for TFPI2 Gene

Unigene Clusters for TFPI2 Gene

Tissue factor pathway inhibitor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFPI2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TFPI2 Gene

GeneLoc Exon Structure for
TFPI2
ECgene alternative splicing isoforms for
TFPI2

Expression for TFPI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TFPI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFPI2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for TFPI2 Gene

This gene is overexpressed in Amniocyte (45.2) and Placenta (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFPI2 Gene



Protein tissue co-expression partners for TFPI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TFPI2 Gene:

TFPI2

SOURCE GeneReport for Unigene cluster for TFPI2 Gene:

Hs.438231

mRNA Expression by UniProt/SwissProt for TFPI2 Gene:

P48307-TFPI2_HUMAN
Tissue specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Evidence on tissue expression from TISSUES for TFPI2 Gene

  • Nervous system(4.3)
  • Lung(3.9)
  • Heart(2.8)
genes like me logo Genes that share expression patterns with TFPI2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TFPI2 Gene

Orthologs for TFPI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFPI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFPI2 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia TFPI2 34 35
  • 80.52 (n)
cow
(Bos Taurus)
Mammalia TFPI2 34 35
  • 80.46 (n)
rat
(Rattus norvegicus)
Mammalia Tfpi2 34
  • 68.33 (n)
mouse
(Mus musculus)
Mammalia Tfpi2 34 16 35
  • 67.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TFPI2 35
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELP 35
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TFPI2 34 35
  • 63.72 (n)
lizard
(Anolis carolinensis)
Reptilia TFPI2 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfpi2 34
  • 62.07 (n)
zebrafish
(Danio rerio)
Actinopterygii tfpi2 34 35
  • 52.89 (n)
worm
(Caenorhabditis elegans)
Secernentea mec-9 35
  • 8 (a)
ManyToMany
F22E12.1 35
  • 6 (a)
ManyToMany
ZK287.4 35
  • 5 (a)
ManyToMany
mec-1 35
  • 3 (a)
ManyToMany
Species where no ortholog for TFPI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFPI2 Gene

ENSEMBL:
Gene Tree for TFPI2 (if available)
TreeFam:
Gene Tree for TFPI2 (if available)

Paralogs for TFPI2 Gene

(13) SIMAP similar genes for TFPI2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TFPI2: view

Variants for TFPI2 Gene

Sequence variations from dbSNP and Humsavar for TFPI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000218731 -- 93,888,916(+) CTAAC(C/T)TGTCA intron-variant, upstream-variant-2KB
rs1000512824 -- 93,890,249(+) TCGTA(G/T)TAGTA upstream-variant-2KB, reference, stop-gained
rs1000586619 -- 93,889,939(+) GTCAG(C/T)TGGGA intron-variant, upstream-variant-2KB
rs1000716037 -- 93,888,649(+) AGAAA(A/G)AGAAA intron-variant
rs1000956366 -- 93,890,390(+) AGAAC(A/G)TCCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TFPI2 Gene

Variant ID Type Subtype PubMed ID
nsv1023193 CNV gain 25217958
nsv607849 CNV gain 21841781

Variation tolerance for TFPI2 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFPI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFPI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPI2 Gene

Disorders for TFPI2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TFPI2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant ovarian cyst
fibrosarcoma
  • fibrocytic tumor
choriocarcinoma
  • chorioepithelioma
rh isoimmunization
  • rh incompatibility affecting management of mother
- elite association - COSMIC cancer census association via MalaCards
Search TFPI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFPI2

Genetic Association Database (GAD)
TFPI2
Human Genome Epidemiology (HuGE) Navigator
TFPI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFPI2
genes like me logo Genes that share disorders with TFPI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFPI2 Gene

Publications for TFPI2 Gene

  1. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. (PMID: 7896752) Miyagi Y. … Miyazaki K. (J. Biochem. 1994) 2 3 4 22 64
  2. Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer. (PMID: 17208328) Rollin J. … Gruel Y. (Lung Cancer 2007) 3 22 46 64
  3. Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors. (PMID: 16247609) Siegling S. … GAPtting C. (Ann. Hematol. 2006) 3 22 46 64
  4. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. (PMID: 11342222) Kamei S. … Kisiel W. (Biochim. Biophys. Acta 2001) 3 4 22 64
  5. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. (PMID: 8945635) Miyagi Y. … Miyazaki K. (DNA Cell Biol. 1996) 2 3 22 64

Products for TFPI2 Gene

  • Cloud-Clone Corp. Antibodies for TFPI2
  • Cloud-Clone Corp. Proteins for TFPI2
  • Cloud-Clone Corp Assay Kits for TFPI2

Sources for TFPI2 Gene

Content
Loading form....