TFPI2 Gene

Aliases
for TFPI2 gene

Previous GC identifers: GC07M092051 GC07M093113 GC07M093127 GC07M093159 GC07M093352 GC07M088123

Summaries
for TFPI2 gene

Genomic Views
for TFPI2 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFPI2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPI2

TFPI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M093514:  view genomic region     (about GC identifiers)

Proteins
for TFPI2 gene

1 PDB 3D structure from and Proteopedia for TFPI2:

1ZR0 (3D)    

Explore the universe of human proteins at neXtProt for TFPI2: NX_P48307

TFPI2 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TFPI2 (TFPI-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TFPI2 OriGene Custom Protein Services for TFPI2
	GenScript Custom Purified and Recombinant Proteins Services for TFPI2
	Novus Biologicals TFPI2 Proteins Novus Biologicals TFPI2 Lysates
	Sino Biological Recombinant Protein for TFPI2
	ProSpec Recombinant Protein for TFPI2
	Uscn Proteins for TFPI2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TFPI2
	R&D Systems Antibodies for TFPI2 (TFPI-2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for TFPI2
	GenScript Custom Superior Antibodies Services for TFPI2
	Novus Biologicals TFPI2 Antibodies
	Search for Antibodies for TFPI2 at Abcam
	Uscn Antibodies for TFPI2
	Search ThermoFisher Antibodies for TFPI2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TFPI2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TFPI2

Protein Domains /
Families
for TFPI2 gene

ProtoNet protein and cluster: P48307

Function
for TFPI2 gene

miRNA Products:		miRTarBase miRNAs that target TFPI2: hsa-mir-616 (MIRT005774)
		OriGene 3'-UTR Clone: TFPI2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFPI2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TFPI2:
		hsa-miR-548am hsa-miR-548x hsa-miR-3182 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: TFPI2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFPI2 (see all 7) OriGene shRNA RFP: TFPI2 OriGene siRNA: TFPI2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFPI2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TFPI2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFPI2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFPI2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TFPI2 (NM_006528)
		Sino Biological Human cDNA Clone for TFPI2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFPI2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPI2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TFPI2
		Search LifeMap BioReagents cell lines for TFPI2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for TFPI2 gene

	Super-pathway	contained gene-specific pathways
1	Development_CNTF receptor signaling	Cell adhesion_Plasmin signaling 0.07 Cell adhesion Plasmin signaling 0.07
2	Matrix Metalloproteinases	Inhibition of Matrix Metalloproteinases 0.68
3	Formation of Fibrin Clot (Clotting Cascade)	Blood Coagulation Signaling Pathways 0.51

1 EMD Millipore Pathway for TFPI2

Cell adhesion Plasmin signaling

1 R&D Systems Pathway for TFPI2

Blood Coagulation Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TFPI2

Inhibition of Matrix Metalloproteinases

1 GeneGo (Thomson Reuters) Pathway for TFPI2

Cell adhesion Plasmin signaling

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for TFPI2 gene

Transcripts
for TFPI2 gene

Expression
for TFPI2 gene

TFPI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTTTAAC

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartRight Ventricle			Heart
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	Posterior foregut-like cells (A scalable, suspensi...)
	Alveolar type II cells (Derivation of mature...)			Lung
	HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)			Bone
	HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFPI2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFPI2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFPI2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFPI2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI2

Orthologs
for TFPI2 gene

Paralogs
for TFPI2 gene

Paralogs for TFPI2 gene

AMBP²  SPINT3²  WFDC8²  TFPI²  WFIKKN1²  SPINT2²  WFIKKN2²  EPPIN²  

EPPIN-WFDC6²  

13 SIMAP similar genes for TFPI2 using alignment to 5 protein entries:     TFPI2_HUMAN (see all proteins):

EPPIN    COL28A1    SPINT3    COL6A3    WFIKKN2    PAPLN

SPINT2    TFPI    APLP2    SPINT4    AMBP    APP

WFDC8

TFPI2 for paralogs           About GeneDecksing

Genomic Variants
for TFPI2 gene

10/177 NCBI SNPs in TFPI2 are shown (see all 177)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs25196501,2	C,F,A,H,	--	88129253(-)	TGCTAT/CGGTTC	3	--	us2k1		15		NS EA NA WA CSA	1891
rs750283981,2	F,	--	92843376(+)	TTTTTG/TATAGA	3	--	ds5001		1		EA	120
rs349144951,2	C,F,H,	--	92843811(+)	AGTATA/GTATCT	3	--	ds5001		16		NS EA NA	1998
rs777225141,2		--	92844560(+)	TTTTTA/GTAAGT	3	--	ut31		0	--	--	--	--
rs753930161,2		--	92844751(+)	AAATCA/GGTCAA	3	--	ut31		1		NA	120
rs1125790991,2		--	92844943(+)	AATATG/ATTAAA	3	--	ut31		1		CSA	2
rs732274851,2	C,	--	92845624(+)	TAGAAG/ATAGTC	3	--	int1		2		NA	122
rs769105781,2	C,	--	92845788(+)	GTCATC/TCCCTC	6	G N D	syn1 mis1		0	--	--	--	--
rs753627351,2		--	92845792(+)	TTCCCT/CCCACA	6	/E /G	mis1 syn1		1		NA	4550
rs1179745371,2	C,F,	--	92846500(+)	TCTCTG/ATGTCT	3	--	int1		1		NA	120

HapMap Linkage Disequilibrium report for TFPI2 (93514709 - 93520303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TFPI2
     4 CNVs: 94701 82083 94702 94699

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFPI2

DNA2.0 Custom Variant and Variant Library Synthesis for TFPI2

Disorders / Diseases
for TFPI2 gene

20/41 diseases for TFPI2

10/20 Novoseek disease relationships for TFPI2 gene (see all 20)    About this table

Publications
for TFPI2 gene

PubMed articles for TFPI2 gene, integrated from 9 sources (see all 150): (articles sorted by number of sources associating them with TFPI2)

Utopia: connect your pdf to the dynamic world of online information

1. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. (PubMed id 7896752)^{1, 2, 3, 9} Miyagi Y.... Miyazaki K. (1994)
2. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. (PubMed id 8159751)^{1, 2, 9} Sprecher C.A.... Foster D.C. (1994)
3. Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. (PubMed id 11342222)^{1, 2, 9} Kamei S.... Kisiel W. (2001)
4. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. (PubMed id 8945635)^{1, 3, 9} Miyagi Y....Miyazaki K. (1996)
5. Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition. (PubMed id 15932872)^{1, 2} Schmidt A.E.... Bajaj S.P. (2005)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
10. Purification and characterization of placental protein 5. (PubMed id 3276312)^{1, 2} Buetzow R.... Seppaelae M. (1988)

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Products
for TFPI2 gene