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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFPI Gene

protein-coding   GIFtS: 66
GCID: GC02M188328

Tissue Factor Pathway Inhibitor (Lipoprotein-Associated...


(Previous symbol: LACI)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation
Inhibitor)1 2
     TFI2
LACI1 2 3 5     anti-convertin2
Extrinsic Pathway Inhibitor1 2 3     Tissue Factor Pathway Inhibitor2
EPI2 3     Lipoprotein-Associated Coagulation Inhibitor3
TFPI12 3     

External Ids:    HGNC: 117601   Entrez Gene: 70352   Ensembl: ENSG000000034367   OMIM: 1523105   UniProtKB: P106463   

Export aliases for TFPI gene to outside databases

Previous GC identifers: GC02M186541 GC02M187014 GC02M188295 GC02M188534 GC02M188533 GC02M188156 GC02M188039 GC02M180188


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFPI Gene:
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood
coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which
proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a
fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory
loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both
free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene
have been described, but the full-length nature of some of these variants has not been confirmed. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TFPI Gene: 
TFPI (tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)) is a protein-coding gene. Diseases associated with TFPI include crescentic glomerulonephritis, and dental fluorosis, and among its related super-pathways are Complement and Coagulation Cascades and Intrinsic Pathway. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is SPINT2.

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,
presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the
ability to associate with lipoproteins in plasma

Gene Wiki entry for TFPI (Tissue factor pathway inhibitor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFPI gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   AP-2alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFPI promoter sequence
   Search SABiosciences Chromatin IP Primers for TFPI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32

TFPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M188328:  view genomic region     (about GC identifiers)

Start:
188,328,957 bp from pter      End:
188,430,487 bp from pter
Size:
101,531 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646 (See protein sequence)
Recommended Name: Tissue factor pathway inhibitor precursor  
Size: 304 amino acids; 35015 Da
Subcellular location: Isoform Alpha: Secreted
Subcellular location: Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor
4 PDB 3D structures from and Proteopedia for TFPI:
1ADZ (3D)        1IRH (3D)        1TFX (3D)        4DTG (3D)    
Secondary accessions: O95103 Q53TS4
Alternative splicing: 2 isoforms:  P10646-1   P10646-2   (GPI-anchored)

Explore the universe of human proteins at neXtProt for TFPI: NX_P10646

Explore proteomics data for TFPI at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10646

  • TFPI Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFPI Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001027452.1  NP_006278.1  

    ENSEMBL proteins: 
     ENSP00000376172   ENSP00000397248   ENSP00000409177   ENSP00000386344   ENSP00000342306  
     ENSP00000388159   ENSP00000408170   ENSP00000394185   ENSP00000400179   ENSP00000402954  
     ENSP00000233156  
    Reactome Protein details: P10646
    Human Recombinant Protein Products for TFPI: 
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    Sino Biological Recombinant Protein for TFPI
    Sino Biological Cell Lysate for TFPI 
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    Cloud-Clone Corp. Proteins for TFPI 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA19065458
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0031090organelle membrane IEA--

    TFPI for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for TFPI 
    Cloud-Clone Corp. CLIAs for TFPI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002223 Prot_inh_Kunz-m
     IPR008296 Prot_inhib_I2_TFPI
     IPR020901 Prtase_inh_Kunz-CS

    Graphical View of Domain Structure for InterPro Entry P10646

    ProtoNet protein and cluster: P10646

    1 Blocks protein domain: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

    UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
    Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second
    one with Xa
    Similarity: Contains 3 BPTI/Kunitz inhibitor domains


    TFPI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPI1_HUMAN, P10646
    Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,
    presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the
    ability to associate with lipoproteins in plasma

         Genatlas biochemistry entry for TFPI:
    tissue factor pathway inhibitor,serine proteinase inhibitor,susceptibility gene for venous thrombosis (536GC->T)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS9252393
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    TFPI for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFPI:
     G0/1 arrest  Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfpi):
     cardiovascular system  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton 

    TFPI for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tfpitm1Gjb for TFPI

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFPI 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFPI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFPI 
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    SwitchGear 3'UTR luciferase reporter plasmidTFPI 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TFPI About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Coagulation Signaling Pathways0.51
    3Common Pathway
    Extrinsic Prothrombin Activation Pathway0.69
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Collagen biosynthesis and modifying enzymes
    Blood Coagulation Cascade0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TFPI
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TFPI
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade

    3 BioSystems Pathways for TFPI
        Integrated Breast Cancer Pathway
    Complement and Coagulation Cascades
    Syndecan-4-mediated signaling events


    3        Reactome Pathways for TFPI
        Hemostasis
    Extrinsic Pathway
    Formation of Fibrin Clot (Clotting Cascade)


    1         Kegg Pathway  (Kegg details for TFPI):
        Complement and coagulation cascades


    TFPI for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for TFPI (P106463 ENSP000002331564) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP7P092373, ENSP000002602274I2D: score=2 STRING: ENSP00000260227
    MMP1P039563, ENSP000003227884I2D: score=1 STRING: ENSP00000322788
    MMP8P228943, ENSP000002368264I2D: score=1 STRING: ENSP00000236826
    F10P007423, ENSP000003647094I2D: score=2 STRING: ENSP00000364709
    ELANEP082463, ENSP000002636214I2D: score=2 STRING: ENSP00000263621
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0007598blood coagulation, extrinsic pathway TAS--
    GO:0010466negative regulation of peptidase activity ----
    GO:0010951negative regulation of endopeptidase activity TAS9252393

    TFPI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFPI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFPI (TFPI1)

    2 DrugBank Compounds for TFPI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--11238112 12974870 7559599 8700900 11772005
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor10847421 15179449 20682597

    10/15 Novoseek inferred chemical compound relationships for TFPI gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iptg 53.6 1 7576181 (1)
    phip 51.3 7 9465918 (2), 11593414 (1), 12351149 (1)
    n-methyl-n'-nitrosourea 42.4 2 8692187 (1)
    heparin 39.4 28 10397725 (5), 10479670 (4), 12893029 (3), 11776326 (2) (see all 8)
    1,3-butadiene 37.2 2 9464313 (1), 11018742 (1)
    mspi 37.1 2 10496984 (1)
    cycloheximide 14.7 4 9459350 (1), 10479670 (1), 10397725 (1)
    serine 7.29 3 10398162 (1), 10082661 (1), 10496984 (1)
    lactose 7.28 1 1737361 (1)
    phospholipid 0 1 8318508 (1)

    Search CenterWatch for drugs/clinical trials and news about TFPI / TFPI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFPI gene (2 alternative transcripts): 
    NM_001032281.2  NM_006287.4  

    Unigene Cluster for TFPI:

    Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
    Hs.516578  [show with all ESTs]
    Unigene Representative Sequence: NM_006287
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392365 ENST00000426055 ENST00000481132 ENST00000435414 ENST00000409676(uc002uqb.2)
    ENST00000339091(uc002uqa.2) ENST00000481389 ENST00000437725 ENST00000421427
    ENST00000453013 ENST00000417013 ENST00000420747 ENST00000233156(uc002upy.3)


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    Additional mRNA sequence: 

    AF021834.1 AK130306.1 AK313562.1 BC014332.1 BC015514.1 J03225.1 

    18 DOTS entries:

    DT.417463  DT.91764221  DT.91764219  DT.100814554  DT.95272451  DT.100814550  DT.100814552  DT.100814544 
    DT.95358248  DT.100814555  DT.95272447  DT.97841731  DT.120960870  DT.445092  DT.92024781  DT.95272444 
    DT.95272446  DT.102826119 

    24/330 AceView cDNA sequences (see all 330):

    BF086542 BU752326 AI474639 T41172 AI985214 CR626671 CB141426 AI742856 
    AI767961 BU675150 AW771482 CA429218 BM676764 BM761247 BM987069 AU136083 
    T50282 BU752479 BF086525 AL544855 N53666 AI656717 BM985416 CA424972 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TFPI    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                    -                                                         
    SP2:              -           -     -                                             
    SP3:              -     -     -     -                                             
    SP4:                                                                              


    ECgene alternative splicing isoforms for TFPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFPI expression in normal human tissues (normalized intensities)      TFPI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAAACCA
    TFPI Expression
    About this image


    TFPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Cardiac Myocytes   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
             huvec   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
             huvec   
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             bone marrow cd34+   
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...

    See TFPI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFPI

    SOURCE GeneReport for Unigene cluster: Hs.516578

    UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
    Tissue specificity: Mostly in endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Array including TFPI: 
              Endothelial Cell Biology in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TFPI gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpi1 , 5 tissue factor pathway inhibitor1, 5 73.49(n)1
    61.43(a)1
      2 (49.41 cM)5
    217881  NM_011576.11  NP_035706.11 
     844328555 
    chicken
    (Gallus gallus)
    Aves TFPI1 tissue factor pathway inhibitor (lipoprotein-associated more 62.56(n)
    53.85(a)
      423989  XM_001232100.2  XP_001232101.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFPI6
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    48(a)
    38(a)
    (see all 5)
    1 ↔ 1
    possible ortholog
    (see all 5)
    GL343290.1(383167-429426)
    GL343690.1(197936-206598)
    zebrafish
    (Danio rerio)
    Actinopterygii tfpia1 tissue factor pathway inhibitor a 50.29(n)
    37.07(a)
      359833  NM_182872.1  NP_878292.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F22E12.16
    mec-16
    Protein MEC-1, isoform e
    6(a)
    4(a)
    many ↔ many
    many ↔ many
    V(10453866-10457347)
    V(6956537-6966422)


    ENSEMBL Gene Tree for TFPI (if available)
    TreeFam Gene Tree for TFPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFPI gene
    SPINT22  WFIKKN22  AMBP2  SPINT32  SPINT12  TFPI22  WFIKKN12  
    9 SIMAP similar genes for TFPI using alignment to 7 protein entries:     TFPI1_HUMAN (see all proteins):
    SPINT2    SPINT3    ITIL    COL28A1    SPINT1    TFPI2
    APLP2    SPINT4    EPPIN

    TFPI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1647 SNPs in TFPI are shown (see all 1647)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161228981,2
    C,F--188328514(+) GAGCCG/ACTGAT 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1921488161,2
    --188328738(+) GTATAA/GATTGT 1 -- ds50010--------
    rs1145301911,2
    F--188328814(+) AAAGGC/TAGCTA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1180246971,2
    C,F--188328912(+) GAGCAT/CTGAAT 1 -- ds50011Minor allele frequency- C:0.05EA 120
    rs1822088611,2
    --188328956(+) GCCAGA/GTTTCA 1 -- ds50010--------
    rs1875805821,2
    --188329031(+) GCATGA/GTCTGT 1 -- ut310--------
    rs1905791921,2
    --188329180(+) AAACAC/TGGTAA 1 -- ut310--------
    rs1390509611,2
    --188329217(+) TTCAAA/GCCATC 1 -- ut310--------
    rs1831816511,2
    --188329246(+) GAGTAA/GGTAGT 1 -- ut310--------
    rs81796671,2
    C,H--188329346(+) TTCACC/TTAAGT 1 -- ut315Minor allele frequency- T:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for TFPI (188328957 - 188430487 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for TFPI (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660083CNV Deletion23128226
    dgv4396n71CNV Loss21882294
    dgv4394n71CNV Loss21882294
    nsv875574CNV Loss21882294
    dgv4398n71CNV Loss21882294
    dgv4393n71CNV Loss21882294
    dgv4395n71CNV Loss21882294
    esv28153CNV Loss19812545
    dgv4397n71CNV Loss21882294
    nsv875579CNV Loss21882294


    Human Gene Mutation Database (HGMD): TFPI
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 152310    OMIM disorders: --

    20/40 diseases for TFPI (see all 40):    About MalaCards
    crescentic glomerulonephritis    dental fluorosis    factor vii deficiency    osteonecrosis
    cerebral palsy    venous thromboembolism    leber hereditary optic neuropathy    antiphospholipid syndrome
    disseminated intravascular coagulation    hemophilia    thromboembolism    cerebrovascular accident
    acute myocardial infarction    thrombosis    acromegaly    hyperthyroidism
    cushing's syndrome    protein s deficiency    glomerulonephritis    myocardial infarction

    4 diseases from the University of Copenhagen DISEASES database for TFPI:
    Disseminated intravascular coagulation     Cerebrovascular accident     Heart disease     Atherosclerosis

    TFPI for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for TFPI gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerotic plaque 25.6 4 9354763 (2), 10398162 (2)
    cell damage 12 2 9713170 (1), 14691349 (1)
    thrombosis 9.7 5 11950688 (2), 18590936 (1), 9252393 (1)
    atherosclerosis 5.36 1 9354763 (1)
    sepsis 0 1 11686353 (1)
    necrosis 0 4 19169266 (1), 10397725 (1), 18690350 (1)
    inflammation 0 4 11733073 (1), 19169266 (1), 10494762 (1)
    acute myocardial infarction 0 2 11804978 (1), 15199481 (1)
    tumors 0 6 11159747 (1), 19169266 (1), 11323177 (1), 10397725 (1) (see all 5)
    carcinoma 0 4 12351149 (3)

    Genetic Association Database (GAD): TFPI
    Human Genome Epidemiology (HuGE) Navigator: TFPI (32 documents)

    Export disorders for TFPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFPI gene, integrated from 9 sources (see all 290):
    (articles sorted by number of sources associating them with TFPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. (PubMed id 11772005)1, 2, 7 Mine S.... Kato H. (2002)
    2. Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. (PubMed id 1993173)1, 2, 3 van der Logt C.P.E.... Bertina R.M. (1991)
    3. Association Analysis of Tissue Factor Pathway Inhibitor Polymorphisms and Haplotypes with Osteonecrosis of the Femoral Head in the Korean Population. (PubMed id 18695356)1, 4, 9 Dai X.L....Kim S.Y. (2008)
    4. TFPIb is the GPI-anchored TFPI isoform on human endoth elial cells and placental microsomes. (PubMed id 22144186)1, 2 Girard T.J....Broze G.J. (2012)
    5. A genome-wide association study in Europeans and Sout h Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (2011)
    6. Gene variants associated with venous thrombosis: conf irmation in the MEGA study. (PubMed id 20128871)1, 4 Arellano A.R....Rosendaal F.R. (2010)
    7. Tissue factor pathway inhibitor polymorphisms in wome n with and without a history of venous thrombosis and the effects of postmenopa usal hormone therapy. (PubMed id 20453636)1, 4 Opstad T.B....Sandset P.M. (2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Biochemical characterization of plasma-derived tissue factor pathway inhibitor: post-translational modification of free, full-length form with particular reference to the sugar chain. (PubMed id 19017259)1, 2 Mori Y....Iwanaga S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7035 HGNC: 11760 AceView: TFPI Ensembl:ENSG00000003436 euGenes: HUgn7035
    ECgene: TFPI Kegg: 7035 H-InvDB: TFPI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFPI Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/TFPI
    SeattleSNPshttp://pga.gs.washington.edu/data/tfpi/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFPI gene:
    Search GeneIP for patents involving TFPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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