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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TFPI Gene

protein-coding GIFtS: 66
GCID: GC02M188328

tissue factor pathway inhibitor (lipoprotein-associated...

(Previous symbol: LACI)

Explore 41 diseases affiliated with
TFPI via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)¹ ²		Extrinsic Pathway Inhibitor² ³
LACI¹ ² ³ ⁵		Anti-Convertin¹
EPI¹ ² ³		Tissue Factor Pathway Inhibitor²
TFPI1¹ ² ³		Lipoprotein-Associated Coagulation Inhibitor³
TFI¹ ²

External Ids:	HGNC: 11760¹	Entrez Gene: 7035²	Ensembl: ENSG00000003436⁷	OMIM: 152310⁵	UniProtKB: P10646³

Export aliases for TFPI gene to outside databases

Previous GC identifers: GC02M186541 GC02M187014 GC02M188295 GC02M188534 GC02M188533 GC02M188156 GC02M188039 GC02M180188

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFPI:

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation.

The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates

additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this

gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is

glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with

plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the

full-length nature of some of these variants has not been confirmed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646

Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,

presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability

to associate with lipoproteins in plasma

Gene Wiki entry for TFPI (Tissue factor pathway inhibitor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TFPI gene promoter:
Sp1 AP-1 ATF-2 c-Jun AP-2alpha ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TFPI promoter sequence

Search SABiosciences Chromatin IP Primers for TFPI

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFPI

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32

TFPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPI gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M188328: view genomic region (about GC identifiers)

Start:	188,328,957 bp from pter	End:	188,430,487 bp from pter
Size:	101,531 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646 (See protein sequence)

Recommended Name: Tissue factor pathway inhibitor precursor

Size: 304 amino acids; 35015 Da

Subcellular location: Isoform Alpha: Secreted

Subcellular location: Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor

4 PDB 3D structures from and Proteopedia for TFPI:

1ADZ (3D)

1IRH (3D)

1TFX (3D)

4DTG (3D)

Secondary accessions: O95103 Q53TS4

Alternative splicing: 2 isoforms: P10646-1 P10646-2 (GPI-anchored)

Explore the universe of human proteins at neXtProt for TFPI: NX_P10646

Post-translational modifications:

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10646

TFPI Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001027452.1 NP_006278.1

ENSEMBL proteins:

ENSP00000376172 ENSP00000397248 ENSP00000409177 ENSP00000386344 ENSP00000342306

ENSP00000388159 ENSP00000408170 ENSP00000394185 ENSP00000400179 ENSP00000402954

ENSP00000233156

Reactome Protein details: P10646
Human Recombinant Protein Products:

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	Novus Biologicals TFPI Proteins Novus Biologicals TFPI Lysates
	Sino Biological Recombinant Protein for TFPI
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TFPI

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	19065458
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0031090	organelle membrane	IEA	--

TFPI for ontologies About GeneDecksing

TFPI Antibody Products:

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	Uscn ELISAs and CLIAs for TFPI

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TFPI for domains About GeneDecksing

3 InterPro domains/families:

IPR002223 Prot_inh_Kunz-m

IPR008296 Prot_inhib_I2_TFPI

IPR020901 Prtase_inh_Kunz-CS

Graphical View of Domain Structure for InterPro Entry P10646

ProtoNet protein and cluster: P10646

1 Blocks protein family: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646

Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one

with Xa

Similarity: Contains 3 BPTI/Kunitz inhibitor domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646

Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,

presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability

to associate with lipoproteins in plasma

Genatlas biochemistry entry for TFPI:

tissue factor pathway inhibitor,serine proteinase inhibitor,susceptibility gene for venous thrombosis (536GC->T)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TFPI Browse MicroRNA Expression Plasmids
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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate TFPI:
		hsa-miR-374a* hsa-miR-19b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-27a hsa-miR-27b hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: TFPI 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for TFPI

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TFPI
		Search LifeMap BioReagents cell lines for TFPI

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	TAS	9252393
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--

TFPI for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TFPI:

G0/1 arrest

Increased G1 DNA content

Animal Models:
Mouse knock-out Tfpi^tm1Gjb for TFPI
11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tfpi):

cardiovascular system	craniofacial	embryogenesis	growth/size	homeostasis/metabolism
immune system	integument	limbs/digits/tail	mortality/aging	nervous system
skeleton

TFPI for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of Fibrin Clot (Clotting Cascade)

Formation of Fibrin Clot (Clotting Cascade)

1.00

Blood Coagulation Signaling Pathways

0.51

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

1.00

Syndecan-4-mediated signaling events

Syndecan-4-mediated signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for TFPI

Blood Coagulation Signaling Pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TFPI

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade

3 BioSystems Pathways for TFPI

	Integrated Breast Cancer Pathway
	Complement and Coagulation Cascades
	Syndecan-4-mediated signaling events

3 Reactome Pathways for TFPI

	Hemostasis
	Extrinsic Pathway
	Formation of Fibrin Clot (Clotting Cascade)

1 Kegg Pathway (Kegg details for TFPI):

Complement and coagulation cascades

TFPI for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TFPI

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/19 Interacting proteins for TFPI (P10646³ ENSP00000233156⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP7	P09237³, ENSP00000260227⁴	I2D: score=2 STRING: ENSP00000260227
MMP1	P03956³, ENSP00000322788⁴	I2D: score=1 STRING: ENSP00000322788
MMP8	P22894³, ENSP00000236826⁴	I2D: score=1 STRING: ENSP00000236826
F10	P00742³, ENSP00000364709⁴	I2D: score=2 STRING: ENSP00000364709
ELANE	P08246³, ENSP00000263621⁴	I2D: score=2 STRING: ENSP00000263621

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	TAS	--
GO:0007598	blood coagulation, extrinsic pathway	TAS	--
GO:0010951	negative regulation of endopeptidase activity	TAS	9252393

TFPI for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TFPI for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFPI

2 DrugBank Compounds for TFPI About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coagulation factor VIIa	Coagulation factor VII precursor (see all 5)	9001-25-6	target	--	11238112 12974870 7559599 8700900 11772005
Dalteparin	Daltepariininatrium (see all 13)	9041-08-1	target	inhibitor	10847421 15179449 20682597

10/15 Novoseek chemical compound relationships for TFPI gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iptg	53.6	1	7576181 (1)
phip	51.3	7	9465918 (2), 11593414 (1), 12351149 (1)
n-methyl-n'-nitrosourea	42.4	2	8692187 (1)
heparin	39.4	28	10397725 (5), 10479670 (4), 12893029 (3), 11776326 (2) (see all 8)
1,3-butadiene	37.2	2	9464313 (1), 11018742 (1)
mspi	37.1	2	10496984 (1)
cycloheximide	14.7	4	9459350 (1), 10479670 (1), 10397725 (1)
serine	7.29	3	10398162 (1), 10082661 (1), 10496984 (1)
lactose	7.28	1	1737361 (1)
phospholipid	0	1	8318508 (1)

Search CenterWatch for drugs/clinical trials and news about TFPI / TFPI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TFPI gene (2 alternative transcripts):

NM_001032281.2 NM_006287.4

Unigene Cluster for TFPI:

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

Hs.516578 [show with all ESTs]

Unigene Representative Sequence: NM_006287

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392365 ENST00000426055 ENST00000481132 ENST00000435414 ENST00000409676(uc002uqb.2)

ENST00000339091(uc002uqa.2) ENST00000481389 ENST00000437725 ENST00000421427

ENST00000453013 ENST00000417013 ENST00000420747 ENST00000233156(uc002upy.3)

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate TFPI:
		hsa-miR-374a* hsa-miR-19b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-27a hsa-miR-27b hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: TFPI 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFPI

Additional cDNA sequence:

AF021834.1 AK130306.1 AK313562.1 BC014332.1 BC015514.1 J03225.1

18 DOTS entries:

DT.417463 DT.91764221 DT.91764219 DT.100814554 DT.95272451 DT.100814550 DT.100814552 DT.100814544

DT.95358248 DT.100814555 DT.95272447 DT.97841731 DT.120960870 DT.445092 DT.92024781 DT.95272444

DT.95272446 DT.102826119

24/330 AceView cDNA sequences (see all 330):

BC015514 BM676764 T39445 AI742856 BM987069 CA432487 CA424972 CB141426

BU675150 AI821285 AW771482 CR626209 BG621312 CA418214 N53666 AL544620

AA369928 AW964256 BG540359 AI168305 BQ026438 BU752479 AA302502 BE440073

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TFPI About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10
SP1:							-
SP2:					-				-		-
SP3:					-		-		-		-
SP4:

ECgene alternative splicing isoforms for TFPI

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TFPI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAAACCA

About this image

TFPI expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TFPI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFPI

SOURCE GeneReport for Unigene cluster: Hs.516578

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646

Tissue specificity: Mostly in endothelial cells

SABiosciences Expression via Pathway-Focused PCR Array including TFPI:

Endothelial Cell Biology in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TFPI gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TFPI¹	tissue factor pathway inhibitor (lipoprotein-associated more	62.56(n) 53.85(a)		423989 XM_001232100.2 XP_001232101.1
lizard (Anolis carolinensis)	Reptilia	TFPI⁶ TFPI2⁶ (see all 4)	--	48(a) 32(a) (see all 4)	possible ortholog possible ortholog (see all 4)	GL343290.1(383167-399610) 6(21939715-21946431)
zebrafish (Danio rerio)	Actinopterygii	tfpia¹	tissue factor pathway inhibitor a	50.29(n) 37.07(a)		359833 NM_182872.1 NP_878292.1
worm (Caenorhabditis elegans)	Secernentea	F22E12.1⁶	--	5(a)	1 ↔ 1	V(10453843-10457324)

ENSEMBL Gene Tree for TFPI (if available)
TreeFam Gene Tree for TFPI (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TFPI gene

AMBP² SPINT3² WFDC8² WFIKKN1² SPINT2² WFIKKN2² TFPI2² EPPIN²

EPPIN-WFDC6²

10 SIMAP similar genes for TFPI using alignment to 7 protein entries: TFPI1_HUMAN (see all proteins):

SPINT2 SPINT3 ITIL COL28A1 SPINT1 TFPI2

APLP2 SPINT4 EPPIN PAPLN

TFPI for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3217130^1,2	C	--	180208269(+)	`CTTAA-/ACAA TTTGA`	1	--	int¹		2		NA	4
rs116122898^1,2	C,F,	--	188328514(+)	`GAGCCG/ACTGAT`	1	--	ds500¹		1		WA	118
rs192148816^1,2		--	188328738(+)	`GTATAA/GATTGT`	1	--	ds500¹		0	--	--	--	--
rs114530191^1,2	F,	--	188328814(+)	`AAAGGC/TAGCTA`	1	--	ds500¹		1		WA	118
rs118024697^1,2	F,	--	188328912(+)	`GAGCAT/CTGAAT`	1	--	ds500¹		1		EA	120
rs182208861^1,2		--	188328956(+)	`GCCAGA/GTTTCA`	1	--	ds500¹		0	--	--	--	--
rs187580582^1,2		--	188329031(+)	`GCATGA/GTCTGT`	1	--	ut3¹		0	--	--	--	--
rs190579192^1,2		--	188329180(+)	`AAACAC/TGGTAA`	1	--	ut3¹		0	--	--	--	--
rs139050961^1,2		--	188329217(+)	`TTCAAA/GCCATC`	1	--	ut3¹		0	--	--	--	--
rs183181651^1,2		--	188329246(+)	`GAGTAA/GGTAGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TFPI (188328957 - 188430487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TFPI
7 CNVs: 90182 63259 78903 78905 78904 4322 3404
Human Gene Mutation Database (HGMD): TFPI

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TFPI for disorders           About GeneDecksing

OMIM gene information: 152310    OMIM disorders: --

20/41 diseases for TFPI (see all 41):    About MalaCards

disseminated intravascular coagulation leber hereditary optic neuropathy factor vii deficiency dental fluorosis

pre-eclampsia acute myocardial infarction myocardial infarction crescentic glomerulonephritis

cerebrovascular accident coronary heart disease cerebral palsy antiphospholipid syndrome

cushing's syndrome hemophilia eclampsia glomerulonephritis

osteonecrosis thrombosis diabetes mellitus acromegaly

4 diseases from the University of Copenhagen DISEASES database for TFPI:

Disseminated intravascular coagulation Cerebrovascular accident Heart disease Atherosclerosis

10/11 Novoseek disease relationships for TFPI gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerotic plaque	25.6	4	9354763 (2), 10398162 (2)
cell damage	12	2	9713170 (1), 14691349 (1)
thrombosis	9.7	5	11950688 (2), 18590936 (1), 9252393 (1)
atherosclerosis	5.36	1	9354763 (1)
sepsis	0	1	11686353 (1)
necrosis	0	4	19169266 (1), 10397725 (1), 18690350 (1)
inflammation	0	4	11733073 (1), 19169266 (1), 10494762 (1)
acute myocardial infarction	0	2	11804978 (1), 15199481 (1)
tumors	0	6	11159747 (1), 19169266 (1), 11323177 (1), 10397725 (1) (see all 5)
carcinoma	0	4	12351149 (3)

Genetic Association Database (GAD): TFPI
Human Genome Epidemiology (HuGE) Navigator: TFPI (32 documents)

Export disorders for TFPI gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TFPI gene, integrated from 9 sources (see all 276):
(articles sorted by number of sources associating them with TFPI)

Utopia: connect your pdf to the dynamic
world of online information

Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. (PubMed id 11772005)^{1, 2, 7} Mine S.... Kato H. (2002)
Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. (PubMed id 1993173)^{1, 2, 3} van der Logt C.P.E.... Bertina R.M. (1991)
TFPIb is the GPI-anchored TFPI isoform on human endoth elial cells and placental microsomes. (PubMed id 22144186)^{1, 2} Girard T.J....Broze G.J. (2012)
Biochemical characterization of plasma-derived tissue factor pathway inhibitor: post-translational modification of free, full-length form with particular reference to the sugar chain. (PubMed id 19017259)^{1, 2} Mori Y....Iwanaga S. (2009)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Genetic factors contribute to bleeding after cardiac surgery. (PubMed id 15892865)^{1, 4} Welsby I.J....Stafford-Smith M. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations. (PubMed id 12195688)^{1, 4} Ameziane N....de Prost D. (2002)
The tissue factor pathway inhibitor C536T mutation is not associated with the risk of stroke in young adults. (PubMed id 12038800)^{1, 4} Junker R....Nabavi D.G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7035	HGNC: 11760	AceView: TFPI	Ensembl:ENSG00000003436	euGenes: HUgn7035
ECgene: TFPI	Kegg: 7035	H-InvDB: TFPI

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TFPI	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/TFPI
SeattleSNPs	http://pga.gs.washington.edu/data/tfpi/

Intellectual Property for TFPI gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TFPI gene:
Search GeneIP for patents involving TFPI

GeneCards and IP:
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