Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TFPI Gene

protein-coding   GIFtS: 68
GCID: GC02M188328

Tissue Factor Pathway Inhibitor (Lipoprotein-Associated...


(Previous symbol: LACI)
  See TFPI-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation
Inhibitor)1 2
     TFI2
LACI1 2 3 5     anti-convertin2
Extrinsic Pathway Inhibitor1 2 3     Tissue Factor Pathway Inhibitor2
EPI2 3     Lipoprotein-Associated Coagulation Inhibitor3
TFPI12 3     

External Ids:    HGNC: 117601   Entrez Gene: 70352   Ensembl: ENSG000000034367   OMIM: 1523105   UniProtKB: P106463   

Export aliases for TFPI gene to outside databases

Previous GC identifers: GC02M186541 GC02M187014 GC02M188295 GC02M188534 GC02M188533 GC02M188156 GC02M188039 GC02M180188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TFPI Gene:
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood
coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which
proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a
fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory
loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both
free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene
have been described, but the full-length nature of some of these variants has not been confirmed. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TFPI Gene:
TFPI (tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)) is a protein-coding gene. Diseases associated with TFPI include crescentic glomerulonephritis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is WFIKKN2.

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,
presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the
ability to associate with lipoproteins in plasma

Gene Wiki entry for TFPI (Tissue factor pathway inhibitor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFPI gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   AP-2alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFPI promoter sequence
   Search Chromatin IP Primers for TFPI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32

TFPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFPI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M188328:  view genomic region     (about GC identifiers)

Start:
188,328,957 bp from pter      End:
188,430,487 bp from pter
Size:
101,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646 (See protein sequence)
Recommended Name: Tissue factor pathway inhibitor precursor  
Size: 304 amino acids; 35015 Da
5 PDB 3D structures from and Proteopedia for TFPI:
1ADZ (3D)        1IRH (3D)        1TFX (3D)        4BQD (3D)        4DTG (3D)    
Secondary accessions: O95103 Q53TS4
Alternative splicing: 2 isoforms:  P10646-1   P10646-2   (GPI-anchored)

Explore the universe of human proteins at neXtProt for TFPI: NX_P10646

Explore proteomics data for TFPI at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Thr42, Thr115, Thr116, Asn145, Asn195, Ser202, Thr203
  • Modification sites at PhosphoSitePlus

  • See TFPI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027452.1  NP_006278.1  

    ENSEMBL proteins: 
     ENSP00000376172   ENSP00000397248   ENSP00000409177   ENSP00000386344   ENSP00000342306  
     ENSP00000388159   ENSP00000408170   ENSP00000394185   ENSP00000400179   ENSP00000402954  
     ENSP00000233156  
    Reactome Protein details: P10646

    TFPI Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TFPI
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TFPI
    OriGene Protein Over-expression Lysate for TFPI
    OriGene MassSpec for TFPI
    OriGene Custom Protein Services for TFPI
    GenScript Custom Purified and Recombinant Proteins Services for TFPI
    Novus Biologicals TFPI Proteins
    Novus Biologicals TFPI Lysates
    Sino Biological Recombinant Protein for TFPI
    Sino Biological Cell Lysate for TFPI
    ProSpec Recombinant Protein for TFPI
    Cloud-Clone Corp. Proteins for TFPI

     
    Search eBioscience for Proteins for TFPI 

     
    antibodies-online proteins for TFPI (24 products) 

     
    antibodies-online peptides for TFPI

    TFPI Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TFPI
    OriGene Antibodies for TFPI
    OriGene Custom Antibody Services for TFPI
    Novus Biologicals TFPI Antibodies
    Abcam antibodies for TFPI
    Cloud-Clone Corp. Antibodies for TFPI
    ThermoFisher Antibodies for TFPI
    antibodies-online antibodies for TFPI (88 products) 

    TFPI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TFPI
    R&D Systems ELISAs for TFPI         (see all)
    GenScript Custom Assay Services for TFPI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TFPI
    Cloud-Clone Corp. CLIAs for TFPI
    Search eBioscience for ELISAs for TFPI 
    antibodies-online kits for TFPI (40 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR002223 Prot_inh_Kunz-m
     IPR008296 Prot_inhib_I2_TFPI
     IPR020901 Prtase_inh_Kunz-CS

    Graphical View of Domain Structure for InterPro Entry P10646

    ProtoNet protein and cluster: P10646

    1 Blocks protein domain: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

    UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
    Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second
    one with Xa
    Similarity: Contains 3 BPTI/Kunitz inhibitor domains


    Find genes that share domains with TFPI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFPI1_HUMAN, P10646
    Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity,
    presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the
    ability to associate with lipoproteins in plasma

         Genatlas biochemistry entry for TFPI:
    tissue factor pathway inhibitor,serine proteinase inhibitor,susceptibility gene for venous thrombosis (536GC->T)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS9252393
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    Find genes that share ontologies with TFPI           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFPI:
     G0/1 arrest  Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfpi):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton 

    Find genes that share phenotypes with TFPI           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tfpitm1Gjb for TFPI

       genOway: Develop your customized and physiologically relevant rodent model for TFPI

    miRNA
    Products:
        
    miRTarBase miRNAs that target TFPI:
    hsa-mir-16-5p (MIRT031813), hsa-mir-155-5p (MIRT020797), hsa-mir-92a-3p (MIRT048954), hsa-mir-132-3p (MIRT021798), hsa-mir-335-5p (MIRT018341), hsa-mir-98-5p (MIRT027730), hsa-mir-7-5p (MIRT025882)

    Block miRNA regulation of human, mouse, rat TFPI using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TFPI:
    hsa-miR-374a* hsa-miR-19b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-27a hsa-miR-27b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidTFPI 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TFPI
    Predesigned siRNA for gene silencing in human, mouse, rat TFPI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TFPI

    Clone
    Products:
         
    OriGene clones in human, mouse for TFPI (see all 15)
    OriGene ORF clones in mouse, rat for TFPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TFPI (NM_006287)
    Sino Biological Human cDNA Clone for TFPI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPI

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TFPI
    Browse ESI BIO Cell Lines and PureStem Progenitors for TFPI 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TFPI1_HUMAN, P10646: Isoform Alpha: Secreted
    TFPI1_HUMAN, P10646: Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    endoplasmic reticulum3
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA19065458
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0031090organelle membrane IEA--

    Find genes that share ontologies with TFPI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TFPI About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Extrinsic Prothrombin Activation Pathway0.00
    Blood Coagulation Signaling Pathways0.51
    Extrinsic Pathway0.00
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Hemostasis
    Hemostasis0.43
    4Collagen biosynthesis and modifying enzymes
    Blood Coagulation Cascade0.38
    5Syndecan-4-mediated signaling events
    Syndecan-4-mediated signaling events


    Find genes that share SuperPaths with TFPI           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TFPI
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TFPI
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade

    3 BioSystems Pathways for TFPI
        Integrated Breast Cancer Pathway
    Complement and Coagulation Cascades
    Syndecan-4-mediated signaling events


    1 Reactome Pathway for TFPI
        Extrinsic Pathway


    1 Kegg Pathway  (Kegg details for TFPI):
        Complement and coagulation cascades

        Pathway & Disease-focused RT2 Profiler PCR Array including TFPI: 
              Endothelial Cell Biology in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TFPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TFPI (P106463 ENSP000002331564) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP7P092373, ENSP000002602274I2D: score=2 STRING: ENSP00000260227
    MMP1P039563, ENSP000003227884I2D: score=1 STRING: ENSP00000322788
    MMP8P228943, ENSP000002368264I2D: score=1 STRING: ENSP00000236826
    F10P007423, ENSP000003647094I2D: score=2 STRING: ENSP00000364709
    ELANEP082463, ENSP000002636214I2D: score=2 STRING: ENSP00000263621
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0007598blood coagulation, extrinsic pathway TAS--
    GO:0010466negative regulation of peptidase activity ----
    GO:0010951negative regulation of endopeptidase activity TAS9252393

    Find genes that share ontologies with TFPI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFPI (TFPI1)

    2 DrugBank Compounds for TFPI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--11238112 12974870 7559599 8700900 11772005
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor10847421 15179449 20682597

    Selected Novoseek inferred chemical compound relationships for TFPI gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iptg 53.6 1 7576181 (1)
    phip 51.3 7 9465918 (2), 11593414 (1), 12351149 (1)
    n-methyl-n'-nitrosourea 42.4 2 8692187 (1)
    heparin 39.4 28 10397725 (5), 10479670 (4), 12893029 (3), 11776326 (2) (see all 8)
    1,3-butadiene 37.2 2 9464313 (1), 11018742 (1)
    mspi 37.1 2 10496984 (1)
    cycloheximide 14.7 4 9459350 (1), 10479670 (1), 10397725 (1)
    serine 7.29 3 10398162 (1), 10082661 (1), 10496984 (1)
    lactose 7.28 1 1737361 (1)
    phospholipid 0 1 8318508 (1)



    Find genes that share compounds with TFPI           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TFPI gene (2 alternative transcripts): 
    NM_001032281.2  NM_006287.4  

    Unigene Cluster for TFPI:

    Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
    Hs.516578  [show with all ESTs]
    Unigene Representative Sequence: NM_006287
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392365 ENST00000426055 ENST00000481132 ENST00000435414 ENST00000409676(uc002uqb.2)
    ENST00000339091(uc002uqa.2) ENST00000481389 ENST00000437725 ENST00000421427
    ENST00000453013 ENST00000417013 ENST00000420747 ENST00000233156(uc002upy.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TFPI using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TFPI:
    hsa-miR-374a* hsa-miR-19b hsa-miR-7-1* hsa-miR-7-2* hsa-miR-27a hsa-miR-27b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidTFPI 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TFPI
    Predesigned siRNA for gene silencing in human, mouse, rat TFPI
    Clone
    Products:
         
    OriGene clones in human, mouse for TFPI (see all 15)
    OriGene ORF clones in mouse, rat for TFPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TFPI (NM_006287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPI
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TFPI
    OriGene qSTAR qPCR primer pairs in human, mouse for TFPI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPI
      QuantiTect SYBR Green Assays in human, mouse, rat TFPI
      QuantiFast Probe-based Assays in human, mouse, rat TFPI

    Additional mRNA sequence: 

    AF021834.1 AK130306.1 AK313562.1 BC014332.1 BC015514.1 J03225.1 

    18 DOTS entries:

    DT.417463  DT.91764221  DT.91764219  DT.100814554  DT.95272451  DT.100814550  DT.100814552  DT.100814544 
    DT.95358248  DT.100814555  DT.95272447  DT.97841731  DT.120960870  DT.445092  DT.92024781  DT.95272444 
    DT.95272446  DT.102826119 

    Selected AceView cDNA sequences (see all 330):

    AI767961 BX386277 AA302502 AA369928 N30373 BG621312 AL544620 BM975483 
    AI168305 BQ026438 AW964256 BM845091 BE440073 T50282 CB141426 W74597 
    T39445 BM987069 AI985214 AI656717 CR626671 BF086542 CA424972 BM676764 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TFPI    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                    -                                                         
    SP2:              -           -     -                                             
    SP3:              -     -     -     -                                             
    SP4:                                                                              


    ECgene alternative splicing isoforms for TFPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TFPI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAAACCA
    TFPI Expression
    About this image


    TFPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Brain (Nervous System)
             Cerebral Cortex
    TFPI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFPI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516578

    UniProtKB/Swiss-Prot: TFPI1_HUMAN, P10646
    Tissue specificity: Mostly in endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Array including TFPI: 
              Endothelial Cell Biology in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TFPI
    OriGene qSTAR qPCR primer pairs in human, mouse for TFPI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPI
    QuantiTect SYBR Green Assays in human, mouse, rat TFPI
    QuantiFast Probe-based Assays in human, mouse, rat TFPI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TFPI gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfpi1 , 5 tissue factor pathway inhibitor1, 5 74.33(n)1
    62.77(a)1
      2 (49.41 cM)5
    217881  NM_011576.11  NP_035706.11 
     844328555 
    chicken
    (Gallus gallus)
    Aves TFPI1 tissue factor pathway inhibitor (lipoprotein-associated more 60.98(n)
    54.37(a)
      423989  XM_004942403.1  XP_004942460.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFPI6
    tissue factor pathway inhibitor (lipoprotein-assoc...
    48(a)
    1 ↔ 1
    GL343290.1(383167-429426)
    zebrafish
    (Danio rerio)
    Actinopterygii tfpia1 tissue factor pathway inhibitor a 52.1(n)
    38.83(a)
      359833  NM_182872.1  NP_878292.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F22E12.16
    ZK287.46
    (see all 4)
    Protein F22E12.1 (F22E12.1) mRNA, complete cds
    Protein ZK287.4, isoform c (ZK287.4) mRNA, complet...
    (see all 4)
    7(a)
    6(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(10453866-10457347) WBGene00009058
    V(9680375-9685659) WBGene00013965


    ENSEMBL Gene Tree for TFPI (if available)
    TreeFam Gene Tree for TFPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TFPI gene
    WFIKKN22  AMBP2  SPINT32  TFPI22  WFIKKN12  
    9 SIMAP similar genes for TFPI using alignment to 7 protein entries:     TFPI1_HUMAN (see all proteins):
    SPINT2    SPINT3    ITIL    COL28A1    SPINT1    TFPI2
    APLP2    SPINT4    EPPIN

    Find genes that share paralogs with TFPI           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TFPI (see all 1647)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161228981,2
    C,F--188328514(+) GAGCCG/ACTGAT 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1921488161,2
    --188328738(+) GTATAA/GATTGT 1 -- ds50010--------
    rs1145301911,2
    F--188328814(+) AAAGGC/TAGCTA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1180246971,2
    C,F--188328912(+) GAGCAT/CTGAAT 1 -- ds50011Minor allele frequency- C:0.05EA 120
    rs1822088611,2
    --188328956(+) GCCAGA/GTTTCA 1 -- ds50010--------
    rs1875805821,2
    --188329031(+) GCATGA/GTCTGT 1 -- ut310--------
    rs1905791921,2
    --188329180(+) AAACAC/TGGTAA 1 -- ut310--------
    rs1390509611,2
    --188329217(+) TTCAAA/GCCATC 1 -- ut310--------
    rs1831816511,2
    --188329246(+) GAGTAA/GGTAGT 1 -- ut310--------
    rs81796671,2
    C,H--188329346(+) TTCACC/TTAAGT 1 -- ut315Minor allele frequency- T:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for TFPI (188328957 - 188430487 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TFPI (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660083CNV Deletion23128226
    dgv4396n71CNV Loss21882294
    dgv4394n71CNV Loss21882294
    nsv875574CNV Loss21882294
    dgv4398n71CNV Loss21882294
    dgv4393n71CNV Loss21882294
    dgv4395n71CNV Loss21882294
    esv28153CNV Loss19812545
    dgv4397n71CNV Loss21882294
    nsv875579CNV Loss21882294

    Human Gene Mutation Database (HGMD): TFPI
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFPI
    DNA2.0 Custom Variant and Variant Library Synthesis for TFPI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 152310    OMIM disorders: --

    1 disease for TFPI:    
    About MalaCards
    crescentic glomerulonephritis

    4 diseases from the University of Copenhagen DISEASES database for TFPI:
    Disseminated intravascular coagulation     Cerebrovascular accident     Heart disease     Atherosclerosis

    Find genes that share disorders with TFPI           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TFPI gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerotic plaque 25.6 4 9354763 (2), 10398162 (2)
    cell damage 12 2 9713170 (1), 14691349 (1)
    thrombosis 9.7 5 11950688 (2), 18590936 (1), 9252393 (1)
    atherosclerosis 5.36 1 9354763 (1)
    sepsis 0 1 11686353 (1)
    necrosis 0 4 19169266 (1), 10397725 (1), 18690350 (1)
    inflammation 0 4 11733073 (1), 19169266 (1), 10494762 (1)
    acute myocardial infarction 0 2 11804978 (1), 15199481 (1)
    tumors 0 6 11159747 (1), 19169266 (1), 11323177 (1), 10397725 (1) (see all 5)
    carcinoma 0 4 12351149 (3)

    Genetic Association Database (GAD): TFPI
    Human Genome Epidemiology (HuGE) Navigator: TFPI (32 documents)

    Export disorders for TFPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TFPI gene, integrated from 10 sources (see all 296):
    (articles sorted by number of sources associating them with TFPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. (PubMed id 11772005)1, 2, 7 Mine S.... Kato H. (Biochemistry 2002)
    2. Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. (PubMed id 1993173)1, 2, 3 van der Logt C.P.E.... Bertina R.M. (Biochemistry 1991)
    3. Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. (PubMed id 18695356)1, 4, 9 Dai X.L....Kim T.H. (Mol. Cells 2008)
    4. TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes. (PubMed id 22144186)1, 2 Girard T.J.... Broze G.J. Jr. (Blood 2012)
    5. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (Nat. Genet. 2011)
    6. Gene variants associated with venous thrombosis: confirmation in the MEGA study. (PubMed id 20128871)1, 4 Arellano A.R....Rosendaal F.R. (J. Thromb. Haemost. 2010)
    7. Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy. (PubMed id 20453636)1, 4 Opstad T.B....Sandset P.M. (amp 2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    9. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7035 HGNC: 11760 AceView: TFPI Ensembl:ENSG00000003436 euGenes: HUgn7035
    ECgene: TFPI Kegg: 7035 H-InvDB: TFPI

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TFPI Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/TFPI
    SeattleSNPshttp://pga.gs.washington.edu/data/tfpi/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TFPI gene:
    Search GeneIP for patents involving TFPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TFPI (TFPI)   Browse Cell Culture Products  
     ELISAs for TFPI (TFPI)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for TFPI (TFPI)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TFPI (TFPI)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for TFPI (TFPI)  
     OriGene Antibodies for TFPI   OriGene RNAi products in human, mouse, rat for TFPI  
     OriGene qPCR primer pairs and template standards for TFPI   OriGene Protein Over-expression Lysate for TFPI  
     OriGene MassSpec for TFPI   OriGene clones in human, mouse for TFPI  
     OriGene qSTAR qPCR primer pairs in human, mouse for TFPI   OriGene Purified Protein for TFPI  
     OriGene ORF clones in mouse, rat for TFPI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TFPI   OriGene Custom Protein Services for TFPI  

     
     
     Block miRNA regulation of human, mouse, rat TFPI using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TFPI
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFPI Predesigned siRNA for gene silencing in human, mouse, rat TFPI
     QuantiFast Probe-based Assays in human, mouse, rat TFPI QuantiTect SYBR Green Assays in human, mouse, rat TFPI
     PCR Arrays including human, mouse, rat TFPI Search Chromatin IP Primers for TFPI
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFPI  GeneGlobe Interaction Network for TFPI
     Regulatory tfbs in TFPI promoter
     GenScript Custom Purified and Recombinant Proteins Services for TFPI GenScript cDNA clones with any tag delivered in your preferred vector for TFPI
     GenScript Custom Assay Services for TFPI GenScript Custom overexpressing Cell Line Services for TFPI
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TFPI (TFPI1)
     Proteins for TFPI
     Cell Lysates for TFPI
     cDNA Clones for TFPI
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TFPI antibodies
     TFPI proteins
     TFPI lysates
     Antibodies for TFPI
     See all of Abcam's Antibodies, Kits and Proteins for TFPI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TFPI
     Proteins for TFPI
     Antibodies for TFPI
     ELISAs for TFPI
     CLIAs for TFPI



     Browse ESI BIO Cell Lines and PureStem Progenitors for TFPI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFPI
     SwitchGear 3'UTR luciferase reporter plasmids for TFPI
     SwitchGear Promoter luciferase reporter plasmids for TFPI
     ThermoFisher Antibodies for TFPI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFPI
     Browse compounds at ApexBio
     Search Addgene for plasmids for TFPI
      Search eBioscience for proteins for TFPI
      Search eBioscience for elisas for TFPI
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TFPI
     antibodies-online antibodies for TFPI (88 products)
     antibodies-online kits for TFPI (40 products)
     antibodies-online peptides for TFPI
     antibodies-online proteins for TFPI (24 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TFPI gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4