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Aliases for TFPI Gene

Aliases for TFPI Gene

  • Tissue Factor Pathway Inhibitor 2 3 5
  • Extrinsic Pathway Inhibitor 2 3 4
  • Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) 2 3
  • TFPI1 3 4
  • LACI 3 4
  • EPI 3 4
  • Lipoprotein-Associated Coagulation Inhibitor 4
  • Anti-Convertin 3
  • TFI 3

External Ids for TFPI Gene

Previous HGNC Symbols for TFPI Gene

  • LACI

Previous GeneCards Identifiers for TFPI Gene

  • GC02M186541
  • GC02M187014
  • GC02M188295
  • GC02M188534
  • GC02M188533
  • GC02M188156
  • GC02M188039
  • GC02M180188
  • GC02M188328

Summaries for TFPI Gene

Entrez Gene Summary for TFPI Gene

  • This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFPI Gene

TFPI (Tissue Factor Pathway Inhibitor) is a Protein Coding gene. Diseases associated with TFPI include disseminated intravascular coagulation and crescentic glomerulonephritis. Among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is AMBP.

UniProtKB/Swiss-Prot for TFPI Gene

  • Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Gene Wiki entry for TFPI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFPI Gene

Genomics for TFPI Gene

Regulatory Elements for TFPI Gene

Enhancers for TFPI Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TFPI on UCSC Golden Path with GeneCards custom track

Promoters for TFPI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TFPI on UCSC Golden Path with GeneCards custom track

Genomic Location for TFPI Gene

Chromosome:
2
Start:
187,464,230 bp from pter
End:
187,565,760 bp from pter
Size:
101,531 bases
Orientation:
Minus strand

Genomic View for TFPI Gene

Genes around TFPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFPI Gene

Proteins for TFPI Gene

  • Protein details for TFPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10646-TFPI1_HUMAN
    Recommended name:
    Tissue factor pathway inhibitor
    Protein Accession:
    P10646
    Secondary Accessions:
    • O95103
    • Q53TS4

    Protein attributes for TFPI Gene

    Size:
    304 amino acids
    Molecular mass:
    35015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TFPI Gene

    Alternative splice isoforms for TFPI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFPI Gene

Proteomics data for TFPI Gene at MOPED

Post-translational modifications for TFPI Gene

Antibody Products

No data available for DME Specific Peptides for TFPI Gene

Domains & Families for TFPI Gene

Protein Domains for TFPI Gene

Suggested Antigen Peptide Sequences for TFPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10646

UniProtKB/Swiss-Prot:

TFPI1_HUMAN :
  • This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
Domain:
  • This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
  • Contains 3 BPTI/Kunitz inhibitor domains.
genes like me logo Genes that share domains with TFPI: view

No data available for Gene Families for TFPI Gene

Function for TFPI Gene

Molecular function for TFPI Gene

GENATLAS Biochemistry:
tissue factor pathway inhibitor,serine proteinase inhibitor,susceptibility gene for venous thrombosis (536GC->T)
UniProtKB/Swiss-Prot Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
genes like me logo Genes that share phenotypes with TFPI: view

Animal Models for TFPI Gene

MGI Knock Outs for TFPI:

Animal Model Products

  • Taconic Biosciences Mouse Models for TFPI

miRNA for TFPI Gene

miRTarBase miRNAs that target TFPI

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFPI Gene

Localization for TFPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFPI Gene

Isoform Alpha: Secreted.
Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFPI Gene COMPARTMENTS Subcellular localization image for TFPI gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TFPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TFPI: view

Pathways & Interactions for TFPI Gene

genes like me logo Genes that share pathways with TFPI: view

SIGNOR curated interactions for TFPI Gene

Activates:

Gene Ontology (GO) - Biological Process for TFPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007598 blood coagulation, extrinsic pathway TAS --
GO:0010951 negative regulation of endopeptidase activity TAS 9252393
genes like me logo Genes that share ontologies with TFPI: view

Drugs & Compounds for TFPI Gene

(23) Drugs for TFPI Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coagulation factor VIIa Approved Pharma Target 0
Dalteparin Approved Pharma Target, inhibitor 283
Aspirin Approved Pharma Channel blocker 1059
serine Nutra 862
Anticoagulants Pharma 2337

(10) Additional Compounds for TFPI Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFPI: view

Transcripts for TFPI Gene

Unigene Clusters for TFPI Gene

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFPI Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: - - - -
SP4:

Relevant External Links for TFPI Gene

GeneLoc Exon Structure for
TFPI
ECgene alternative splicing isoforms for
TFPI

Expression for TFPI Gene

mRNA expression in normal human tissues for TFPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFPI Gene

This gene is overexpressed in Liver (x6.1) and Lung (x4.7).

Protein differential expression in normal tissues from HIPED for TFPI Gene

This gene is overexpressed in Amniocyte (29.3), Serum (15.8), and Liver (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFPI Gene



SOURCE GeneReport for Unigene cluster for TFPI Gene Hs.516578

mRNA Expression by UniProt/SwissProt for TFPI Gene

P10646-TFPI1_HUMAN
Tissue specificity: Mostly in endothelial cells.
genes like me logo Genes that share expression patterns with TFPI: view

Protein tissue co-expression partners for TFPI Gene

Primer Products

In Situ Assay Products

Orthologs for TFPI Gene

This gene was present in the common ancestor of animals.

Orthologs for TFPI Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TFPI 35
  • 81.38 (n)
  • 74.92 (a)
mouse
(Mus musculus)
Mammalia Tfpi 35
  • 74.33 (n)
  • 62.77 (a)
Tfpi 16
Tfpi 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TFPI 35
  • 99.34 (n)
  • 99.01 (a)
TFPI 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfpi 35
  • 75.24 (n)
  • 63.41 (a)
dog
(Canis familiaris)
Mammalia TFPI 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TFPI 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFPI 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFPI 35
  • 60.98 (n)
  • 54.37 (a)
TFPI 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFPI 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tfpia 35
  • 52.1 (n)
  • 38.83 (a)
tfpia 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F22E12.1 36
  • 7 (a)
ManyToMany
mec-1 36
  • 4 (a)
ManyToMany
mec-9 36
  • 10 (a)
ManyToMany
ZK287.4 36
  • 6 (a)
ManyToMany
Species with no ortholog for TFPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TFPI Gene

ENSEMBL:
Gene Tree for TFPI (if available)
TreeFam:
Gene Tree for TFPI (if available)

Paralogs for TFPI Gene

Paralogs for TFPI Gene

genes like me logo Genes that share paralogs with TFPI: view

Variants for TFPI Gene

Sequence variations from dbSNP and Humsavar for TFPI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_012004 -
rs2067770 -- 187,553,563(-) ATAAC(A/G)TGCCT intron-variant
rs10153820 -- 187,554,863(+) AGTGA(A/G)ACAAT upstream-variant-2KB
rs10185334 -- 187,552,500(+) CAGAA(G/T)ATTTA intron-variant
rs7560548 -- 187,556,026(+) cctgc(C/T)gagtg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TFPI Gene

Variant ID Type Subtype PubMed ID
nsv834487 CNV Gain 17160897
dgv4393n71 CNV Loss 21882294
nsv875560 CNV Loss 21882294
dgv4394n71 CNV Loss 21882294
dgv4395n71 CNV Loss 21882294
dgv4396n71 CNV Loss 21882294
nsv834488 CNV Gain+Loss 17160897
dgv4397n71 CNV Loss 21882294
nsv875572 CNV Loss 21882294
nsv875574 CNV Loss 21882294
nsv875575 CNV Gain 21882294
dgv4398n71 CNV Loss 21882294
nsv875579 CNV Loss 21882294
dgv4399n71 CNV Loss 21882294
dgv1281e1 CNV Complex 17122850
esv28153 CNV Loss 19812545
esv2660083 CNV Deletion 23128226
nsv875584 CNV Loss 21882294

Variation tolerance for TFPI Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFPI Gene

HapMap Linkage Disequilibrium report
TFPI
Human Gene Mutation Database (HGMD)
TFPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFPI Gene

Disorders for TFPI Gene

MalaCards: The human disease database

(6) MalaCards diseases for TFPI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
disseminated intravascular coagulation
  • defibrination syndrome
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
middle cerebral artery infarction
  • infarction middle cerebral artery
factor x deficiency
  • disease, stuart-prower
factor v deficiency
  • quebec platelet disorder
- elite association - COSMIC cancer census association via MalaCards
Search TFPI in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFPI

Genetic Association Database (GAD)
TFPI
Human Genome Epidemiology (HuGE) Navigator
TFPI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFPI
genes like me logo Genes that share disorders with TFPI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFPI Gene

Publications for TFPI Gene

  1. Intron-exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. (PMID: 1993173) van der Logt C.P.E. … Bertina R.M. (Biochemistry 1991) 2 3 4 67
  2. Testosterone alleviates tumor necrosis factor-alpha-mediated tissue factor pathway inhibitor downregulation via suppression of nuclear factor-kappa B in endothelial cells. (PMID: 19169266) Jin H. … Tan X.R. (Asian J. Androl. 2009) 3 23
  3. Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells. (PMID: 18217145) Nadir Y. … Vlodavsky I. (Thromb. Haemost. 2008) 3 23
  4. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. (PMID: 18310227) Bastarache J.A. … Ware L.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008) 3 23
  5. Adiponectin inhibits tissue factor expression and enhances tissue factor pathway inhibitor expression in human endothelial cells. (PMID: 18690350) Chen Y.J. … Chen F.P. (Thromb. Haemost. 2008) 3 23

Products for TFPI Gene

Sources for TFPI Gene

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