Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TFIP11 Gene

Aliases for TFIP11 Gene

  • Tuftelin Interacting Protein 11 2 3
  • Septin And Tuftelin-Interacting Protein 1 3 4
  • STIP-1 3 4
  • TIP39 3 6
  • NTR1 3 6
  • Tuftelin-Interacting Protein 11 3
  • BK445C9.6 3
  • Spp382 3
  • HNtr1 3
  • StIP 4

External Ids for TFIP11 Gene

Summaries for TFIP11 Gene

Entrez Gene Summary for TFIP11 Gene

  • TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly in Cajal bodies (Stanek et al., 2008 [PubMed 18367544]).[supplied by OMIM, Apr 2009]

GeneCards Summary for TFIP11 Gene

TFIP11 (Tuftelin Interacting Protein 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TFIP11 Gene

  • Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.

Gene Wiki entry for TFIP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFIP11 Gene

Genomics for TFIP11 Gene

Genomic Location for TFIP11 Gene

Start:
26,491,225 bp from pter
End:
26,512,505 bp from pter
Size:
21,281 bases
Orientation:
Minus strand

Genomic View for TFIP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFIP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFIP11 Gene

Regulatory Elements for TFIP11 Gene

Proteins for TFIP11 Gene

  • Protein details for TFIP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBB9-TFP11_HUMAN
    Recommended name:
    Tuftelin-interacting protein 11
    Protein Accession:
    Q9UBB9
    Secondary Accessions:
    • O95908
    • Q20WL0
    • Q5H8V8
    • Q9UGV7
    • Q9Y2Q8

    Protein attributes for TFIP11 Gene

    Size:
    837 amino acids
    Molecular mass:
    96820 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.

    Alternative splice isoforms for TFIP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFIP11 Gene

Proteomics data for TFIP11 Gene at MOPED

Post-translational modifications for TFIP11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys159 and Lys780

No data available for DME Specific Peptides for TFIP11 Gene

Domains for TFIP11 Gene

Gene Families for TFIP11 Gene

HGNC:
  • GPATCH :G patch domain containing

Protein Domains for TFIP11 Gene

UniProtKB/Swiss-Prot:

TFP11_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • Q9UBB9
Family:
  • Belongs to the TFP11/STIP family.:
    • Q9UBB9
genes like me logo Genes that share domains with TFIP11: view

Function for TFIP11 Gene

Molecular function for TFIP11 Gene

UniProtKB/Swiss-Prot Function: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.

Gene Ontology (GO) - Molecular Function for TFIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TFIP11: view

Phenotypes for TFIP11 Gene

GenomeRNAi human phenotypes for TFIP11:
genes like me logo Genes that share phenotypes with TFIP11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TFIP11 Gene

Localization for TFIP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFIP11 Gene

Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFIP11 Gene COMPARTMENTS Subcellular localization image for TFIP11 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TFIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005634 nucleus --
GO:0005681 spliceosomal complex IDA 11991638
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with TFIP11: view

Pathways for TFIP11 Gene

SuperPathways for TFIP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000390 spliceosomal complex disassembly IMP 19103666
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IC 11991638
GO:0031214 biomineral tissue development IEA --
genes like me logo Genes that share ontologies with TFIP11: view

No data available for Pathways by source for TFIP11 Gene

Transcripts for TFIP11 Gene

Unigene Clusters for TFIP11 Gene

Tuftelin interacting protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFIP11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - -
SP14: - - - -
SP15: - - - - - - - - -
SP16: - - - - - - -
SP17: - - -
SP18:
SP19:
SP20:

ExUns: 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:

Relevant External Links for TFIP11 Gene

GeneLoc Exon Structure for
TFIP11
ECgene alternative splicing isoforms for
TFIP11

Expression for TFIP11 Gene

mRNA expression in normal human tissues for TFIP11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFIP11 Gene

SOURCE GeneReport for Unigene cluster for TFIP11 Gene Hs.20225

genes like me logo Genes that share expressions with TFIP11: view

Orthologs for TFIP11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TFIP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFIP11 36
  • 99.56 (n)
  • 99.88 (a)
TFIP11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFIP11 36
  • 87.57 (n)
  • 93.43 (a)
TFIP11 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFIP11 36
  • 91.2 (n)
  • 97.25 (a)
TFIP11 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfip11 36
  • 85.66 (n)
  • 92.11 (a)
Tfip11 16
Tfip11 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 85 (a)
OneToMany
TFIP11 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tfip11 36
  • 86.06 (n)
  • 92.35 (a)
chicken
(Gallus gallus)
Aves TFIP11 36
  • 79.89 (n)
  • 90.45 (a)
TFIP11 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4331 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4686 36
tfip11 36
  • 74.91 (n)
  • 81.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10819 36
zebrafish
(Danio rerio)
Actinopterygii tfip11 36
  • 66.63 (n)
  • 67.64 (a)
tfip11 37
  • 67 (a)
OneToOne
wufd15a02 36
fruit fly
(Drosophila melanogaster)
Insecta sip1 36
  • 49.22 (n)
  • 38.89 (a)
sip1 37
  • 35 (a)
OneToOne
sip1 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea stip-1 36
  • 45.66 (n)
  • 35.69 (a)
stip-1 37
  • 31 (a)
OneToOne
C07E3.1a 38
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17070 36
  • 48.38 (n)
  • 38.3 (a)
rice
(Oryza sativa)
Liliopsida Os12g0615800 36
  • 48.15 (n)
  • 37.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06950 36
  • 46.26 (n)
  • 28.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.03c 36
  • 40.76 (n)
  • 28.57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8614 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for TFIP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFIP11 Gene

ENSEMBL:
Gene Tree for TFIP11 (if available)
TreeFam:
Gene Tree for TFIP11 (if available)

Paralogs for TFIP11 Gene

No data available for Paralogs for TFIP11 Gene

Variants for TFIP11 Gene

Sequence variations from dbSNP and Humsavar for TFIP11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs16362 -- 26,505,774(+) GAGTG(-/CAGTGGCGTG)ATCTC intron-variant
rs134134 -- 26,502,925(+) GAGAA(C/T)ACCTG intron-variant
rs134135 -- 26,502,996(+) GAAGA(C/G)TAACA intron-variant
rs134136 -- 26,503,508(+) CACCC(C/T)AGCCC intron-variant
rs134137 -- 26,507,631(+) TCTCC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFIP11 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724091 CNV Deletion 23290073
dgv1397e1 CNV Complex 17122850

Relevant External Links for TFIP11 Gene

HapMap Linkage Disequilibrium report
TFIP11

Disorders for TFIP11 Gene

Relevant External Links for TFIP11

Genetic Association Database (GAD)
TFIP11
Human Genome Epidemiology (HuGE) Navigator
TFIP11
genes like me logo Genes that share disorders with TFIP11: view

No data available for UniProtKB/Swiss-Prot for TFIP11 Gene

Publications for TFIP11 Gene

  1. Enamel formation genes are associated with high caries experience in Turkish children. (PMID: 18781068) Patir A. … Vieira A.R. (Caries Res. 2008) 3 23 49
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. (PMID: 10806191) Paine C.T. … Snead M.L. (J. Biol. Chem. 2000) 2 3
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for TFIP11 Gene

Sources for TFIP11 Gene

Back to Top

Content