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Aliases & Descriptions for TFIP11
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZP434B194 1 FLJ22086 2 NTR1 2 , 5 OTTHUMP00000028715 2 STIP 3 STIP-1 3 TIP39 1 , 2 , 5 bK445C9.6 2 hNtr1 2
Descriptions Septin and tuftelin-interacting protein 1 3 tuftelin interacting protein 11 2
Search outside databases for aliases for TFIP11 genePrevious GC identifer: GC22M023583
Summaries for TFIP11 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TFIP11 : TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly inCajal bodies (Stanek et al., 2008 [PubMed 18367544]).[supplied by OMIM] UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9 Function : May play a role in the differentiation of ameloblasts and odontoblasts or in the formingof the enamel extracellular matrix. May also be involved in pre-mRNA splicing
Gene Wiki entry for TFIP11
Genomic Location for TFIP11
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TFIP11 gene Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1 TFIP11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22M025211:
(about GC identifiers )
Start:
25,217,191 bp from pter
End:
25,238,471 bp from pter
Size:
21,281 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000022.9 NT_011520.11 Proteins for TFIP11
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9 (See
protein sequence )Recommended Name: Tuftelin-interacting protein 11 Size : 837 amino acids; 96820 Da
Subunit : Interacts with TUFT1 (By similarity). Identified in the spliceosome C complex, at leastcomposed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14,DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK,HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE,PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2,SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE,SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions : O95908 Q5H8V8 Q9UGV7 Q9Y2Q8Alternative splicing : 2 isoforms : Q9UBB9-1 Q9UBB9-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001008697.1 NP_036275.1 ENSEMBL proteins: ENSP00000384297 ENSP00000383892 ENSP00000385861 ENSP00000384421 ENSP00000263115 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for TFIP11: Assays for TFIP11:
Protein
Domains/ Families for TFIP11(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UBB9 ProtoNet protein and cluster: Q9UBB9
1 Blocks protein family : IPB000467 D111/G-patch domain UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9 Similarity : Belongs to the TFP11/STIP familySimilarity : Contains 1 G-patch domain
Gene Function for TFIP11
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001008697 Applied Biosystems Silencer ® siRNAs for TFIP11 Sigma-Aldrich siRNA for TFIP11 Sigma-Aldrich shRNA for TFIP11 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008697                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008697                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001008697  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001008697 UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9 Function : May play a role in the differentiation of ameloblasts and odontoblasts or in the formingof the enamel extracellular matrix. May also be involved in pre-mRNA splicing
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0005515 protein binding
ISS --
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Pathways & Interactions for TFIP11
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for TFIP11 (ENSP00000263115 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for TFIP11 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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PharmGKB )
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Transcripts for TFIP11(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001008697 Sigma-Aldrich siRNA for TFIP11 Sigma-Aldrich shRNA for TFIP11 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001008697 NM_012143
REFSEQ mRNAs for TFIP11 gene (2 alternative transcripts): NM_001008697.1 NM_012143.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001008697 NM_012143
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008697                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001008697                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001008697  
Additional cDNA sequence: AF070662.1 AK025739.1 AK298303.1 AK299964.1 AL050258.1 AL080147.1 BC011599.2 BC033080.1 BT007274.1 CR620578.1 CT841511.2
24/27 DOTS entries (see all 27
): DT.101970424 DT.87016562 DT.95270594 DT.92440640 DT.120665916 DT.101968225 DT.209571 DT.92440648 DT.100818713 DT.95270592 DT.100685466 DT.100774480 DT.102833547 DT.120665962 DT.99965479 DT.92440641 DT.92440646 DT.100718978 DT.100818714 DT.120665910 DT.120665960 DT.40264250 DT.95270590 DT.100653717
24/228 AceView cDNA sequences (see all 228
):AK025443 CD624260 BX354918 BC011599 AI186271 BX453239 BX356477 BX456727 CR620578 BM711431 CD624262 CF132262 BQ220411 BG940415 AL041422 BQ896749 BU178336 AW515732 BC033080 CD368621 AV648630 AL045582 BQ129252 AL050258
highest scoring ESTs for TFIP11 :AA001171 AL039939 AL041422 AL045018 AL050258 AL080147 AU098977 AU280729 BC011599 BC033080
Unigene Cluster for TFIP11: Tuftelin interacting protein 11 Hs.20225 [show with all ESTs ] Unigene Representative Sequence: AL050258 GeneLoc Exon Structure 5/20 Alternative Splicing Database (ASD) splice patterns (SP) for TFIP11 (see all 20
) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^ SP1 :                                           -   -       -   SP2 :         -     -                               -   -       -   SP3 :         -     -   -   -                           -   -       -   SP4 :         -     -   -                                       SP5 :         -     -       -   -                                
ExUns: 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 SP1 :     -               -             SP2 :                               SP3 :                               SP4 :                               SP5 :                              
About this scheme ECgene alternative splicing isoforms for TFIP11 5 Ensembl transcripts including schematic representations : ENST00000405938
ENST00000407431
ENST00000407148
ENST00000407690
ENST00000263115
Expression for TFIP11
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TFIP11 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TFIP11 1 / 2 / 3
5 probe-sets matching TFIP11 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCCAAGTGAASOURCE GeneReport for Unigene cluster: Hs.20225 Expression variation in blood from EXPOLDB for TFIP11
Orthologs for TFIP11
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TFIP11 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for TFIP11 ENSEMBL Gene Tree for TFIP11 Paralogs for TFIP11 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for TFIP11 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TFIP11 (up to first 250kb)
Disorders & Mutations for TFIP11
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 612747 Human Genome Epidemiology Navigator: TFIP11 (2 documents)
Medical News for TFIP11 (Possibly Related Articles in
Doctor's Guide )
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Publications for TFIP11 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for TFIP11 gene (see all 22
): Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 2, 3, 4 Wiemann S.... Poustka A. (2001) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303) 3, 4 Collins J.E....Dunham I. (2003) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638) 3, 4 Jurica M.S.... Moore M.J. (2002) A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. (PubMed id 10806191) 2, 3 Paine C.T....Snead M.L. (2000) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 3, 4 Zhang Q.H....Chen Z. (2000) The DNA sequence of human chromosome 22. (PubMed id 10591208) 3, 4 Dunham I....O'Brien K.P. (1999) Enamel formation genes are associated with high caries experience in Turkish children. (PubMed id 18781068) 1, 3 Patir A....Vieira A.R. (2008)
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Genome Databases showing TFIP11
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing TFIP11
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Specialized Databases showing TFIP11 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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