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TFIP11 Gene

protein-coding   GIFtS: 56

GC22M025211
tuftelin interacting protein 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZP434B194 1
FLJ22086 2
NTR1 2, 5
OTTHUMP00000028715 2
STIP 3
STIP-1 3
TIP39 1, 2, 5
bK445C9.6 2
hNtr1 2
Descriptions
Septin and tuftelin-interacting protein 1 3
tuftelin interacting protein 11 2
External Ids
HGNC: 171651
Entrez Gene: 241442
UniProtKB: Q9UBB93
Ensembl: ENSG000001001097
Search outside databases for aliases for TFIP11 gene

Previous GC identifer: GC22M023583

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TFIP11:
TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly in
Cajal bodies (Stanek et al., 2008 [PubMed 18367544]).[supplied by OMIM]

UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9
Function: May play a role in the differentiation of ameloblasts and odontoblasts or in the forming
of the enamel extracellular matrix. May also be involved in pre-mRNA splicing

Gene Wiki entry for TFIP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TFIP11 gene  

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

TFIP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M025211:     (about GC identifiers)

Start:
25,217,191 bp from pter
End:
25,238,471 bp from pter
Size:
21,281 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9 (See protein sequence)
Recommended Name: Tuftelin-interacting protein 11  
Size: 837 amino acids; 96820 Da
Subunit: Interacts with TUFT1 (By similarity). Identified in the spliceosome C complex, at least
composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14,
DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK,
HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE,
PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2,
SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE,
SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: O95908 Q5H8V8 Q9UGV7 Q9Y2Q8
Alternative splicing: 2 isoforms:  Q9UBB9-1   Q9UBB9-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001008697.1  NP_036275.1  


    ENSEMBL proteins: 
    ENSP00000384297 ENSP00000383892 ENSP00000385861 ENSP00000384421 ENSP00000263115 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (TFIP11)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578 proteinaceous extracellular matrix IEA--
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005681 spliceosome IDA11991638
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for TFIP11: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TFIP11
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for TFIP11

    Assays for TFIP11: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR014809 TFP11
     IPR000467 G_patch


       GeneDecks  TFIP11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UBB9

    ProtoNet protein and cluster: Q9UBB9

    1 Blocks protein family: IPB000467 D111/G-patch domain

    UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9
    Similarity: Belongs to the TFP11/STIP family
    Similarity: Contains 1 G-patch domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TFIP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TFIP11)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001008697

                  Applied Biosystems Silencer® siRNAs for TFIP11

                  Sigma-Aldrich siRNA for TFIP11  
                         Sigma-Aldrich shRNA for TFIP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001008697
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001008697
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001008697 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001008697

    UniProtKB/Swiss-Prot: TFP11_HUMAN, Q9UBB9
    Function: May play a role in the differentiation of ameloblasts and odontoblasts or in the forming
    of the enamel extracellular matrix. May also be involved in pre-mRNA splicing

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0005515 protein binding ISS--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for TFIP11 (ENSP000002631153) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUFT1ENSP000003578423STRING (score=.98)
    AMBNENSP000003138093STRING (score=.716)
    ENAMENSP000002548003STRING (score=.712)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503 ossification IEA--
    GO:0006397 mRNA processing IEA--
    GO:0008380 RNA splicing IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TFIP11

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TFIP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TFIP11)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001008697

                  Sigma-Aldrich siRNA for TFIP11  
                         Sigma-Aldrich shRNA for TFIP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001008697  NM_012143  

    REFSEQ mRNAs for TFIP11 gene (2 alternative transcripts): 

    NM_001008697.1   NM_012143.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001008697  NM_012143  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001008697
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001008697
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001008697 

    Additional cDNA sequence: 

    AF070662.1 AK025739.1 AK298303.1 AK299964.1 AL050258.1 AL080147.1 BC011599.2 BC033080.1 
    BT007274.1 CR620578.1 CT841511.2 

    24/27 DOTS entries (see all 27 ):

    DT.101970424  DT.87016562  DT.95270594  DT.92440640  DT.120665916  DT.101968225  DT.209571  DT.92440648 
    DT.100818713  DT.95270592  DT.100685466  DT.100774480  DT.102833547  DT.120665962  DT.99965479  DT.92440641 
    DT.92440646  DT.100718978  DT.100818714  DT.120665910  DT.120665960  DT.40264250  DT.95270590  DT.100653717 

    24/228 AceView cDNA sequences (see all 228 ):

    AK025443 CD624260 BX354918 BC011599 AI186271 BX453239 BX356477 BX456727 
    CR620578 BM711431 CD624262 CF132262 BQ220411 BG940415 AL041422 BQ896749 
    BU178336 AW515732 BC033080 CD368621 AV648630 AL045582 BQ129252 AL050258 

    highest scoring ESTs for TFIP11:

    AA001171 AL039939 AL041422 AL045018 AL050258 AL080147 AU098977 AU280729 BC011599 BC033080 

    Unigene Cluster for TFIP11:

    Tuftelin interacting protein 11
    Hs.20225  [show with all ESTs]
    Unigene Representative Sequence: AL050258


    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for TFIP11 (see all 20 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9 ^
    SP1:                                                                                                                                -     -                 -   
    SP2:                          -           -                                                                                         -     -                 -   
    SP3:                          -           -     -     -                                                                             -     -                 -   
    SP4:                          -           -     -                                                                                                               
    SP5:                          -           -                 -     -                                                                                             

    ExUns: 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:              -                                         -                                 
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for TFIP11

    5 Ensembl transcripts including schematic representations:
    ENST00000405938  ENST00000407431  ENST00000407148  ENST00000407690  ENST00000263115  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TFIP11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TFIP11

    1 / 2 / 3

    5 probe-sets matching TFIP11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40975_s_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 AL050258 0.80 1.00 0.91 1

    202750_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL080147 0.80 1.00 0.91 1

    202751_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012143 0.60 1.00 0.82 1

    202750_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202751_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCAAGTGAA

    SOURCE GeneReport for Unigene cluster: Hs.20225

    Expression variation in blood from EXPOLDB for TFIP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TFIP11 gene from 5/16 species (see all 16 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TFIP111   -- tuftelin interacting protein 11 91.24(n)
    97.25(a)
    477530  XM_534724.2  XP_534724.1 
    chimpanzee
    (Pan troglodytes)
    TFIP111   -- tuftelin interacting protein 11 99.6(n)
    99.88(a)
    458725  XM_001172293.1  XP_001172293.1 
    cow
    (Bos taurus)
    TFIP111   -- tuftelin interacting protein 11 87.5(n)
    93.19(a)
    509349  NM_001046030.1  NP_001039495.1 
    rat
    (Rattus norvegicus)
    Tfip111   -- tuftelin interacting protein 11 86.06(n)
    92.35(a)
    288718  NM_001008291.1  NP_001008292.1 
    mouse
    (Mus musculus)
    Tfip111, 5 55
    tuftelin interacting protein 111, 5 85.9(n)1
    92.23(a)1
    547231  NM_018783.41  NP_061253.21 
     AF0971815  AF2904745  (see all 17)
    About this table        Species with no ortholog for TFIP11

    ENSEMBL Gene Tree for TFIP11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/144 NCBI SNPs in TFIP11 are shown (see all 144 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 77)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs1341461,2
    C,F,H,O25240295(+) CCTACA/GATGCC 2 -- ng319Minor allele frequency- G:0.14MN EU EA WA 1020
    rs1341451,2
    A,C,F,H25239750(+) AAAGCG/ATACAT 2 -- ng319Minor allele frequency- A:0.31EA EU WA NA 2264
    rs1341441,2
    C,F,H,O25238970(+) TCCAGG/AAGCTG 2 -- ng318Minor allele frequency- A:0.07MN EU EA WA NA 744
    rs117030711,2
    C,F,H25240095(+) cccacG/Ataaag 2 -- ng318Minor allele frequency- A:0.01EU EA WA 840
    rs32135581,2
    C,F,H25238433(+) GAACCC/TGGAAG 2 -- ut518Minor allele frequency- T:0.21EA NA EU WA 2056
    rs60050621,2
    H25229750(+) TTGGGT/CTAATG 2 S/N mis14Minor allele frequency- C:0.00EU EA WA 406
    rs124838681,2
    C25236593(+) AAAATA/GAGTAG 2 -- ut51 ese30--------
    rs347644031,2
    C25236216(+) CATCCC/TGGTAT 2 R/Q mis11Minor allele frequency- T:0.01NA 70
    rs10085301,2
    A,C,F,H25225337(+) AGCTCA/GTGGAA 2 H/H syn123Minor allele frequency- G:0.22MN EU EA WA NA 3686
    rs174022861,2
    C,F,H25224879(+) GACAAG/AAGCTG 2 L/L syn1 ese312Minor allele frequency- A:0.02NA EU EA WA 1036
    About this table

    HapMap Linkage Disequilibrium images for TFIP11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612747

    Human Genome Epidemiology Navigator: TFIP11 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/22 PubMed articles for TFIP11 gene (see all 22 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 24144 HGNC: 17165 AceView: TFIP11 Ensembl:ENSG00000100109 euGenes: HUgn24144
    ECgene: TFIP11 H-InvDB: TFIP11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TFIP11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for TFIP11 Antibodies for TFIP11
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     Lentivirus-delivered shRNAs for TFIP11 Browse small molecules at Sigma-Aldrich
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    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    TFIP11 Gene at Home site.
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