Aliases for TFIP11 Gene
External Ids for TFIP11 Gene
Previous GeneCards Identifiers for TFIP11 Gene
TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly in Cajal bodies (Stanek et al., 2008 [PubMed 18367544]).[supplied by OMIM, Apr 2009]
GeneCards Summary for TFIP11 Gene
TFIP11 (Tuftelin Interacting Protein 11) is a Protein Coding gene. Diseases associated with TFIP11 include dentine erosion. GO annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for TFIP11 Gene
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.