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Aliases for TFG Gene

Aliases for TFG Gene

  • TRK-Fused Gene 2 3
  • TRK-Fused Gene Protein 3 4
  • HMSNP 3 6
  • SPG57 3 6
  • TRKT3 Oncogene 3
  • Protein TFG 3
  • TRKT3 3
  • TF6 3

External Ids for TFG Gene

Previous GeneCards Identifiers for TFG Gene

  • GC03P097099
  • GC03P099713
  • GC03P101709
  • GC03P101749
  • GC03P101910
  • GC03P100428
  • GC03P097796

Summaries for TFG Gene

Entrez Gene Summary for TFG Gene

  • There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for TFG Gene

TFG (TRK-Fused Gene) is a Protein Coding gene. Diseases associated with TFG include spastic paraplegia 57, autosomal recessive and spastic paraplegia, optic atrophy, and neuropathy. Among its related pathways are Pathways in cancer and Thyroid cancer. GO annotations related to this gene include identical protein binding and signal transducer activity.

UniProtKB/Swiss-Prot for TFG Gene

  • Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Wiki entry for TFG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFG Gene

Genomics for TFG Gene

Regulatory Elements for TFG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TFG Gene

100,709,284 bp from pter
100,748,967 bp from pter
39,684 bases
Plus strand

Genomic View for TFG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFG Gene

Proteins for TFG Gene

  • Protein details for TFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TFG
    Protein Accession:
    Secondary Accessions:
    • D3DN49
    • G5E9V1
    • K0J5S8
    • K0J6K2
    • Q15656
    • Q969I2

    Protein attributes for TFG Gene

    400 amino acids
    Molecular mass:
    43448 Da
    Quaternary structure:
    • Self-associates to form an oligomeric complex.

    Alternative splice isoforms for TFG Gene


neXtProt entry for TFG Gene

Proteomics data for TFG Gene at MOPED

Post-translational modifications for TFG Gene

  • Ubiquitination at Lys47 and Lys103
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TFG Gene

Domains for TFG Gene

Protein Domains for TFG Gene


Suggested Antigen Peptide Sequences for TFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PB1 domain.
  • Contains 1 PB1 domain.
genes like me logo Genes that share domains with TFG: view

No data available for Gene Families for TFG Gene

Function for TFG Gene

Molecular function for TFG Gene

GENATLAS Biochemistry:
TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma
UniProtKB/Swiss-Prot Function:
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Ontology (GO) - Molecular Function for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TFG: view

Phenotypes for TFG Gene

genes like me logo Genes that share phenotypes with TFG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TFG Gene

Localization for TFG Gene

Subcellular locations from

Jensen Localization Image for TFG Gene COMPARTMENTS Subcellular localization image for TFG gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 7565764
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TFG Gene

Pathways for TFG Gene

SuperPathways for TFG Gene

genes like me logo Genes that share pathways with TFG: view

Pathways by source for TFG Gene

2 KEGG pathways for TFG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0008219 cell death --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with TFG: view

Drugs for TFG Gene

(1) Novoseek inferred chemical compound relationships for TFG Gene

Compound -log(P) Hits PubMed IDs
tyrosine 30.5 2
genes like me logo Genes that share compounds with TFG: view

Transcripts for TFG Gene

Unigene Clusters for TFG Gene

TRK-fused gene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -

ExUns: 10b ^ 11 ^ 12
SP4: -
SP5: -

Relevant External Links for TFG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFG Gene

mRNA expression in normal human tissues for TFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TFG Gene

This gene is overexpressed in Bone marrow stromal cell (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFG Gene

SOURCE GeneReport for Unigene cluster for TFG Gene Hs.518123

mRNA Expression by UniProt/SwissProt for TFG Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TFG: view

Expression partners for TFG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TFG Gene

Orthologs for TFG Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TFG 35
  • 92.5 (n)
  • 95 (a)
-- 36
  • 91 (a)
TFG 36
  • 95 (a)
(Canis familiaris)
Mammalia TFG 35
  • 93.67 (n)
  • 95.25 (a)
TFG 36
  • 95 (a)
(Mus musculus)
Mammalia Tfg 35
  • 88.38 (n)
  • 91.16 (a)
Tfg 16
Tfg 36
  • 94 (a)
(Pan troglodytes)
Mammalia TFG 35
  • 99.58 (n)
  • 100 (a)
TFG 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC102546978 35
  • 88.41 (n)
  • 91.18 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
-- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TFG 36
  • 89 (a)
(Gallus gallus)
Aves TFG 35
  • 73.69 (n)
  • 79.18 (a)
TFG 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TFG 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2241 35
tfg 35
  • 71.04 (n)
  • 75.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia tfg-prov 35
(Danio rerio)
Actinopterygii tfg 35
  • 62.14 (n)
  • 63.45 (a)
wufb11c10 35
tfg 36
  • 66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3867 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for TFG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFG Gene

Gene Tree for TFG (if available)
Gene Tree for TFG (if available)

Paralogs for TFG Gene

(2) SIMAP similar genes for TFG Gene using alignment to 7 proteins: Pseudogenes for TFG Gene

genes like me logo Genes that share paralogs with TFG: view

No data available for Paralogs for TFG Gene

Variants for TFG Gene

Sequence variations from dbSNP and Humsavar for TFG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7297 -- 100,748,832(-) CACCC(A/T)AGCAT utr-variant-3-prime
rs11353 -- 100,748,174(+) GGACC(C/T)CAACA synonymous-codon, reference
rs12562 -- 100,736,589(+) AGTGC(G/T)CCTGC synonymous-codon, reference
rs186920 -- 100,732,261(+) CAAAA(A/G)GAGGT intron-variant
rs186956 -- 100,740,715(-) ACACA(C/G)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFG Gene

Variant ID Type Subtype PubMed ID
dgv182e55 CNV Gain 17911159
dgv613n27 CNV Gain 19166990
nsv516418 CNV Gain 19592680
nsv877220 CNV Gain 21882294
esv2751970 CNV Gain 17911159
dgv183e55 CNV Gain 17911159
dgv614n27 CNV Gain 19166990
nsv470794 CNV Gain 18288195
nsv460787 CNV Gain 19166990

Relevant External Links for TFG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFG Gene

Disorders for TFG Gene

(3) OMIM Diseases for TFG Gene (602498)


  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
  • Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. {ECO:0000269 PubMed:22883144}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. {ECO:0000269 PubMed:23479643}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for TFG Gene

Disease -log(P) Hits PubMed IDs
thyroid papillary carcinoma 66 2
anaplastic large cell lymphoma 63.4 1
lymphoma 30 2
tumors 0 3

Relevant External Links for TFG

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TFG: view

No data available for University of Copenhagen DISEASES and Genatlas for TFG Gene

Publications for TFG Gene

  1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PMID: 9169129) Mencinger M. … Aman P. (Genomics 1997) 2 3 4 23
  2. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. (PMID: 7565764) Greco A. … Pierotti M.A. (Mol. Cell. Biol. 1995) 3 4 23
  3. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. (PMID: 23479643) Beetz C. … Audhya A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 4
  4. Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. (PMID: 15557341) Roccato E. … Greco A. (J. Biol. Chem. 2005) 3 23
  5. Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. (PMID: 12237775) Roccato E. … Greco A. (Br. J. Cancer 2002) 3 23

Products for TFG Gene

Sources for TFG Gene

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