Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TFG Gene

protein-coding   GIFtS: 63
GCID: GC03P100428

TRK-Fused Gene

  See TFG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TRK-Fused Gene1 2     TF62
TRK-Fused Gene Protein2 3     TRKT32
HMSNP2 5     Protein TFG2
SPG572 5     TRKT3 Oncogene2

External Ids:    HGNC: 117581   Entrez Gene: 103422   Ensembl: ENSG000001143547   OMIM: 6024985   UniProtKB: Q927343   

Export aliases for TFG gene to outside databases

Previous GC identifers: GC03P097099 GC03P099713 GC03P101709 GC03P101749 GC03P101910 GC03P097796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TFG Gene:
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in
several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role
in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. (provided by RefSeq, Sep
2010)

GeneCards Summary for TFG Gene:
TFG (TRK-fused gene) is a protein-coding gene. Diseases associated with TFG include neuropathy, hereditary motor and sensory, okinawa type, and spastic paraplegia, optic atrophy, and neuropathy. GO annotations related to this gene include identical protein binding and signal transducer activity.

Gene Wiki entry for TFG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFG gene promoter:
         AP-1   COUP   NF-kappaB   HNF-1A   COUP-TF   HNF-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFG promoter sequence
   Search Chromatin IP Primers for TFG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2   Ensembl cytogenetic band:  3q12.2   HGNC cytogenetic band: 3q12.2

TFG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P100428:  view genomic region     (about GC identifiers)

Start:
100,428,134 bp from pter      End:
100,467,811 bp from pter
Size:
39,678 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734 (See protein sequence)
Recommended Name: Protein TFG  
Size: 400 amino acids; 43448 Da
Secondary accessions: D3DN49 G5E9V1 Q15656 Q969I2
Alternative splicing: 2 isoforms:  Q92734-1   Q92734-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TFG: NX_Q92734

Explore proteomics data for TFG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys103
  • Modification sites at PhosphoSitePlus

  • See TFG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007566.1  NP_001182407.1  NP_001182408.1  NP_006061.2  

    ENSEMBL proteins: 
     ENSP00000397182   ENSP00000419960   ENSP00000240851   ENSP00000419559   ENSP00000417952  
     ENSP00000419504   ENSP00000420797  

    TFG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TFG
    OriGene Protein Over-expression Lysate for TFG
    OriGene MassSpec for TFG
    OriGene Custom Protein Services for TFG
    GenScript Custom Purified and Recombinant Proteins Services for TFG
    Novus Biologicals TFG Proteins
    Novus Biologicals TFG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFG

     
    Search eBioscience for Proteins for TFG 

     
    antibodies-online proteins for TFG (5 products) 

     
    antibodies-online peptides for TFG

    TFG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TFG
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TFG
    OriGene Custom Antibody Services for TFG
    Novus Biologicals TFG Antibodies
    Abcam antibodies for TFG
    Cloud-Clone Corp. Antibodies for TFG
    ThermoFisher Antibodies for TFG
    LSBio Antibodies in human, mouse, rat for TFG
    antibodies-online antibodies for TFG (31 products) 

    TFG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TFG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TFG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TFG
    Cloud-Clone Corp. CLIAs for TFG
    Search eBioscience for ELISAs for TFG 
    antibodies-online kits for TFG (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000270 OPR_PB1

    Graphical View of Domain Structure for InterPro Entry Q92734

    ProtoNet protein and cluster: Q92734

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p


    Find genes that share domains with TFG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for TFG:
    TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with TFG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFG:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Tfg (no phenotypes)

    Find genes that share phenotypes with TFG           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFG

    miRNA
    Products:
        
    miRTarBase miRNAs that target TFG:
    hsa-mir-106a-5p (MIRT048315), hsa-mir-192-5p (MIRT004131), hsa-mir-193b-3p (MIRT041287), hsa-mir-877-3p (MIRT036854), hsa-mir-92a-3p (MIRT049807)

    Block miRNA regulation of human, mouse, rat TFG using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TFG:
    hsa-miR-142-3p hsa-miR-133a hsa-miR-889 hsa-miR-4255 hsa-miR-133b hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidTFG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TFG
    Predesigned siRNA for gene silencing in human, mouse, rat TFG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TFG

    Clone
    Products:
         
    OriGene clones in human, mouse for TFG (see all 16)
    OriGene ORF clones in mouse, rat for TFG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): TFG (NM_001007565)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TFG
    Browse ESI BIO Cell Lines and PureStem Progenitors for TFG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS7565764

    Find genes that share ontologies with TFG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TFG About    
    See pathways by source

    SuperPathContained pathways About
    1Thyroid cancer
    Thyroid cancer
    2Pathways in cancer
    Pathways in cancer


    Find genes that share SuperPaths with TFG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for TFG):
        Pathways in cancer
    Thyroid cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including TFG: 
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TFG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TFG (Q927341, 2, 3 ENSP000002408514) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48424 MINT-48458 I2D: score=2 
    ARL15Q9NXU52, 3MINT-64619 I2D: score=4 
    C14orf1Q9UKR52, 3MINT-65102 I2D: score=4 
    KIAA1377Q9P2H02, 3MINT-65101 I2D: score=4 
    CRMP1Q141942, 3MINT-65097 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0008219cell death IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with TFG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFG

    1 Novoseek inferred chemical compound relationship for TFG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 30.5 2 12584559 (1), 12237775 (1)



    Find genes that share compounds with TFG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TFG gene (4 alternative transcripts): 
    NM_001007565.2  NM_001195478.1  NM_001195479.1  NM_006070.5  

    Unigene Cluster for TFG:

    TRK-fused gene
    Hs.518123  [show with all ESTs]
    Unigene Representative Sequence: NM_006070
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418917(uc003duf.3) ENST00000490574 ENST00000240851(uc003due.3 uc003dug.3 uc003dui.3)
    ENST00000479672 ENST00000476228 ENST00000463568 ENST00000487505 ENST00000481203

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TFG using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TFG:
    hsa-miR-142-3p hsa-miR-133a hsa-miR-889 hsa-miR-4255 hsa-miR-133b hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidTFG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TFG
    Predesigned siRNA for gene silencing in human, mouse, rat TFG
    Clone
    Products:
         
    OriGene clones in human, mouse for TFG (see all 16)
    OriGene ORF clones in mouse, rat for TFG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): TFG (NM_001007565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TFG
    OriGene qSTAR qPCR primer pairs in human, mouse for TFG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFG
      QuantiTect SYBR Green Assays in human, mouse, rat TFG
      QuantiFast Probe-based Assays in human, mouse, rat TFG

    Additional mRNA sequence: 

    AB097040.1 AB097041.1 AB731569.1 AB731570.1 AK093456.1 AY532911.1 BC001483.2 BC009241.2 
    BC023599.2 BC041600.1 BT007428.1 CR456781.1 Y07968.1 

    Selected DOTS entries (see all 36):

    DT.100883627  DT.448313  DT.97869198  DT.91783534  DT.100883664  DT.95079028  DT.91783472  DT.91869171 
    DT.120847756  DT.101971600  DT.101985164  DT.40127456  DT.422962  DT.120847657  DT.120847769  DT.91783471 
    DT.100883666  DT.120847648  DT.92385321  DT.100883619  DT.120847767  DT.100883623  DT.100883626  DT.100883628 

    Selected AceView cDNA sequences (see all 723):

    AA724501 BG199820 BG203427 BQ071433 AI671585 BM759553 AA281703 AA922048 
    BG184283 BE328269 BM771829 CB152510 CB152539 BU185399 BC023599 AA975925 
    BM837749 AI310955 CB132078 BG214993 BE740277 CR623738 BM834879 AK127920 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TFG (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
    SP1:                                                        -     -     -     -     -                                                                           
    SP2:                                                  -     -     -     -     -     -                                                                           
    SP3:                          -     -     -     -     -     -     -     -     -     -                                                                           
    SP4:                          -     -     -     -     -     -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 10b ^ 11 ^ 12
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:  -               
    SP5:  -               


    ECgene alternative splicing isoforms for TFG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TFG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTACTAAA
    TFG Expression
    About this image


    TFG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    TFG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518123

    UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TFG: 
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TFG
    OriGene qSTAR qPCR primer pairs in human, mouse for TFG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFG
    QuantiTect SYBR Green Assays in human, mouse, rat TFG
    QuantiFast Probe-based Assays in human, mouse, rat TFG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TFG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfg1 , 5 Trk-fused gene1, 5 88.38(n)1
    91.16(a)1
      16 (34.22 cM)5
    217871  NM_019678.31  NP_062652.11 
     566903325 
    chicken
    (Gallus gallus)
    Aves TFG1 TRK-fused gene 73.69(n)
    79.18(a)
      418391  XM_416608.4  XP_416608.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFG6
    TRK-fused gene
    84(a)
    1 ↔ 1
    3(174079907-174100253)
    African clawed frog
    (Xenopus laevis)
    Amphibia tfg-prov2 Trk-fused gene 77.04(n)    BC044079.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11c102 wufb11c10 75.41(n)   336466  BC047167.1 


    ENSEMBL Gene Tree for TFG (if available)
    TreeFam Gene Tree for TFG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TFG gene
    2 SIMAP similar genes for TFG using alignment to 7 protein entries:     TFG_HUMAN (see all proteins):
    TFG-NR4A3 fusion    TFG/ALK fusion

    Find genes that share paralogs with TFG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TFG
    PGOHUM00000243611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TFG (see all 966)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356684
    A colorectal cancer sample4--see VAR_0356682 A S mis40--------
    VAR_0689174
    Hereditary motor and sensory neuropathy, proximal type (HMSNP)4--see VAR_0689172 P L mis40--------
    rs2074822301,2
    Cpathogenic1100434300(+) ACAACC/TTCAGC 8 P L mis10--------
    rs1415804091,2
    --97796552(+) CCTCGC/TTCGAA 4 -- int10--------
    rs30571941,2
    C--97815061(+) aaata-/ATA   
      T
    /TTTA
    AGAAC
    4 -- int12NA 4
    rs716255671,2
    C--97816273(+) AACTCTTA/-TTATT 4 -- int11Minor allele frequency- -:0.50NA 2
    rs105371721,2
    C--97824772(+) AAGCC-/A/AA  
            
    AAAAA
    4 -- int12NA CSA 4
    rs636700601,2
    --97834026(-) AAAAAA/GGGATT 4 -- int10--------
    rs58512201,2
    C--97835893(+) GACATAAAC/-  
            
    AAACA
    4 -- ds50011Minor allele frequency- -:0.50NA 2
    rs2002061211,2
    C--97835944(+) AACTT-/AGTG  
            
    AGTGA
    4 -- ds50010--------

    HapMap Linkage Disequilibrium report for TFG (100428134 - 100467811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TFG:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv183e55CNV Gain17911159
    esv2751970CNV Gain17911159
    nsv516418CNV Gain19592680
    nsv470794CNV Gain18288195
    dgv613n27CNV Gain19166990
    dgv614n27CNV Gain19166990
    nsv877220CNV Gain21882294
    dgv182e55CNV Gain17911159
    nsv460787CNV Gain19166990

    Human Gene Mutation Database (HGMD): TFG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFG
    DNA2.0 Custom Variant and Variant Library Synthesis for TFG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602498   
    OMIM disorders: 604484  612237  615658  
    UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in
    disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas.
    Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3
    (TRK-T3) fusion transcript
  • Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder
    characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations,
    with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles
    amyotrophic lateral sclerosis. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 7 diseases for TFG:    
    About MalaCards
    neuropathy, hereditary motor and sensory, okinawa type    spastic paraplegia, optic atrophy, and neuropathy    spastic paraplegia 57, autosomal recessive    chondrosarcoma
    extraskeletal myxoid chondrosarcoma    myxoid chondrosarcoma    follicular thyroid carcinoma


    Find genes that share disorders with TFG           About GenesLikeMe

    4 Novoseek inferred disease relationships for TFG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 66 2 9169129 (1), 10092511 (1)
    anaplastic large cell lymphoma 63.4 1 10556217 (1)
    lymphoma 30 2 19797732 (2)
    tumors 0 3 19797732 (2), 12584559 (1)

    Genetic Association Database (GAD): TFG

    Export disorders for TFG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TFG gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with TFG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PubMed id 9169129)1, 2, 3, 9 Mencinger M....Aman P. (Genomics 1997)
    2. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. (PubMed id 7565764)1, 2, 9 Greco A....Pierotti M.A. (Mol. Cell. Biol. 1995)
    3. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. (PubMed id 23479643)1, 3 Beetz C....Audhya A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    4. The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement. (PubMed id 22883144)1, 2 Ishiura H.... Tsuji S. (Am. J. Hum. Genet. 2012)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. (PubMed id 15557341)1, 9 Roccato E....Greco A. (J. Biol. Chem. 2005)
    7. Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. (PubMed id 12237775)1, 9 Roccato E....Greco A. (Br. J. Cancer 2002)
    8. Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. (PubMed id 11943732)1, 9 Hernandez L....Campo E. (Am. J. Pathol. 2002)
    9. TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. (PubMed id 10556217)1, 9 HernA!ndez L....Campo E. (Blood 1999)
    10. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. (PubMed id 19797732)1, 9 Chase A....Cross N.C. (Haematologica 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10342 HGNC: 11758 AceView: TFG Ensembl:ENSG00000114354 euGenes: HUgn10342
    ECgene: TFG Kegg: 10342 H-InvDB: TFG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TFG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TFG gene:
    Search GeneIP for patents involving TFG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TFG
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TFG   OriGene RNAi products in human, mouse, rat for TFG  
     OriGene qPCR primer pairs and template standards for TFG   OriGene Protein Over-expression Lysate for TFG  
     OriGene MassSpec for TFG   OriGene clones in human, mouse for TFG  
     OriGene qSTAR qPCR primer pairs in human, mouse for TFG   OriGene Purified Protein for TFG  
     OriGene ORF clones in mouse, rat for TFG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TFG   OriGene Custom Protein Services for TFG  

     
     
     Block miRNA regulation of human, mouse, rat TFG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TFG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFG Predesigned siRNA for gene silencing in human, mouse, rat TFG
     QuantiFast Probe-based Assays in human, mouse, rat TFG QuantiTect SYBR Green Assays in human, mouse, rat TFG
     PCR Arrays including human, mouse, rat TFG Search Chromatin IP Primers for TFG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFG  GeneGlobe Interaction Network for TFG
     Regulatory tfbs in TFG promoter
     GenScript Custom Purified and Recombinant Proteins Services for TFG GenScript cDNA clones with any tag delivered in your preferred vector for TFG
     GenScript Custom Assay Services for TFG GenScript Custom overexpressing Cell Line Services for TFG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TFG
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TFG antibodies
     TFG proteins
     TFG lysates
     Antibodies for TFG
     See all of Abcam's Antibodies, Kits and Proteins for TFG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TFG
     Antibodies for TFG
     ELISAs for TFG
     CLIAs for TFG



     Browse ESI BIO Cell Lines and PureStem Progenitors for TFG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG
     SwitchGear 3'UTR luciferase reporter plasmids for TFG
     SwitchGear Promoter luciferase reporter plasmids for TFG
     ThermoFisher Antibodies for TFG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFG
     LSBio Antibodies in human, mouse, rat for TFG
     Browse compounds at ApexBio
     Search Addgene for plasmids for TFG
      Search eBioscience for proteins for TFG
      Search eBioscience for elisas for TFG
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for TFG (31 products)
     antibodies-online kits for TFG (2 products)
     antibodies-online peptides for TFG
     antibodies-online proteins for TFG (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TFG gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4