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Aliases for TFG Gene

Aliases for TFG Gene

  • TRK-Fused Gene 2 3 5
  • TRK-Fused Gene Protein 3 4
  • TRKT3 Oncogene 3
  • Protein TFG 3
  • HMSNP 3
  • SPG57 3
  • TRKT3 3
  • TF6 3

External Ids for TFG Gene

Previous GeneCards Identifiers for TFG Gene

  • GC03P097099
  • GC03P099713
  • GC03P101709
  • GC03P101749
  • GC03P101910
  • GC03P100428
  • GC03P097796

Summaries for TFG Gene

Entrez Gene Summary for TFG Gene

  • There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for TFG Gene

TFG (TRK-Fused Gene) is a Protein Coding gene. Diseases associated with TFG include Spastic Paraplegia 57, Autosomal Recessive and Hereditary Motor And Sensory Neuropathy, Okinawa Type. Among its related pathways are Pathways in cancer and Vesicle-mediated transport. GO annotations related to this gene include identical protein binding and signal transducer activity.

UniProtKB/Swiss-Prot for TFG Gene

  • Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Wiki entry for TFG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFG Gene

Genomics for TFG Gene

Regulatory Elements for TFG Gene

Enhancers for TFG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TFG on UCSC Golden Path with GeneCards custom track

Promoters for TFG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TFG Gene

Chromosome:
3
Start:
100,709,284 bp from pter
End:
100,748,967 bp from pter
Size:
39,684 bases
Orientation:
Plus strand

Genomic View for TFG Gene

Genes around TFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFG Gene

Proteins for TFG Gene

  • Protein details for TFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92734-TFG_HUMAN
    Recommended name:
    Protein TFG
    Protein Accession:
    Q92734
    Secondary Accessions:
    • D3DN49
    • G5E9V1
    • K0J5S8
    • K0J6K2
    • Q15656
    • Q969I2

    Protein attributes for TFG Gene

    Size:
    400 amino acids
    Molecular mass:
    43448 Da
    Quaternary structure:
    • Self-associates to form an oligomeric complex.

    Alternative splice isoforms for TFG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFG Gene

Post-translational modifications for TFG Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TFG Gene

Domains & Families for TFG Gene

Protein Domains for TFG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92734

UniProtKB/Swiss-Prot:

TFG_HUMAN :
  • Contains 1 PB1 domain.
Domain:
  • Contains 1 PB1 domain.
genes like me logo Genes that share domains with TFG: view

No data available for Gene Families for TFG Gene

Function for TFG Gene

Molecular function for TFG Gene

GENATLAS Biochemistry:
TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma
UniProtKB/Swiss-Prot Function:
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Ontology (GO) - Molecular Function for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with TFG: view
genes like me logo Genes that share phenotypes with TFG: view

Human Phenotype Ontology for TFG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TFG

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TFG Gene

Localization for TFG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFG Gene COMPARTMENTS Subcellular localization image for TFG gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm NAS 7565764
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TFG Gene

Pathways & Interactions for TFG Gene

genes like me logo Genes that share pathways with TFG: view

SIGNOR curated interactions for TFG Gene

Activates:

Gene Ontology (GO) - Biological Process for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TFG: view

Drugs & Compounds for TFG Gene

(1) Drugs for TFG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TFG: view

Transcripts for TFG Gene

Unigene Clusters for TFG Gene

TRK-fused gene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -

ExUns: 10b ^ 11 ^ 12
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TFG Gene

GeneLoc Exon Structure for
TFG
ECgene alternative splicing isoforms for
TFG

Expression for TFG Gene

mRNA expression in normal human tissues for TFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFG Gene

This gene is overexpressed in Bone marrow stromal cell (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFG Gene



Protein tissue co-expression partners for TFG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TFG Gene:

TFG

SOURCE GeneReport for Unigene cluster for TFG Gene:

Hs.518123

mRNA Expression by UniProt/SwissProt for TFG Gene:

Q92734-TFG_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TFG: view

Primer Products

No data available for mRNA differential expression in normal tissues for TFG Gene

Orthologs for TFG Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TFG 34
  • 92.5 (n)
  • 95 (a)
-- 35
  • 91 (a)
OneToMany
TFG 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TFG 34
  • 93.67 (n)
  • 95.25 (a)
TFG 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfg 34
  • 88.38 (n)
  • 91.16 (a)
Tfg 16
Tfg 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TFG 34
  • 99.58 (n)
  • 100 (a)
TFG 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102546978 34
  • 88.41 (n)
  • 91.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TFG 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFG 34
  • 73.69 (n)
  • 79.18 (a)
TFG 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFG 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2241 34
tfg 34
  • 71.04 (n)
  • 75.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia tfg-prov 34
zebrafish
(Danio rerio)
Actinopterygii tfg 34
  • 62.14 (n)
  • 63.45 (a)
wufb11c10 34
tfg 35
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3867 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for TFG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFG Gene

ENSEMBL:
Gene Tree for TFG (if available)
TreeFam:
Gene Tree for TFG (if available)

Paralogs for TFG Gene

(2) SIMAP similar genes for TFG Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TFG Gene

genes like me logo Genes that share paralogs with TFG: view

No data available for Paralogs for TFG Gene

Variants for TFG Gene

Sequence variations from dbSNP and Humsavar for TFG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035668 A colorectal cancer sample
rs430945 - 100,736,627(-) AGGAA(A/G)CAATG reference, missense
rs6772054 - 100,748,418(+) GTTTT(A/C)CTTCA reference, missense
rs207482230 Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO) 100,748,182(+) ACAAC(C/T)TCAGC reference, missense
rs587777175 Spastic paraplegia 57, autosomal recessive (SPG57) 100,728,759(+) ATCTC(C/T)GTCGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TFG Gene

Variant ID Type Subtype PubMed ID
dgv1397e212 CNV gain 25503493
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv4830n100 CNV gain 25217958
dgv613n27 CNV gain 19166990
dgv614n27 CNV gain 19166990
dgv8476n54 CNV gain 21841781
dgv8479n54 CNV gain 21841781
dgv917e214 CNV gain 21293372
esv2751970 CNV gain 17911159
esv2763708 CNV gain 21179565
nsv460787 CNV gain 19166990
nsv470794 CNV gain 18288195
nsv516418 CNV gain 19592680
nsv591164 CNV gain 21841781

Variation tolerance for TFG Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFG Gene

Human Gene Mutation Database (HGMD)
TFG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFG Gene

Disorders for TFG Gene

MalaCards: The human disease database

(16) MalaCards diseases for TFG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 57, autosomal recessive
  • autosomal recessive spastic paraplegia type 57
hereditary motor and sensory neuropathy, okinawa type
  • neuropathy, hereditary motor and sensory, okinawa type
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
spastic paraplegia 57
  • spastic paraplegia 57, autosomal recessive
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TFG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TFG_HUMAN
  • Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. {ECO:0000269 PubMed:22883144}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. {ECO:0000269 PubMed:7565764}.
  • Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. {ECO:0000269 PubMed:23479643}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TFG

Genetic Association Database (GAD)
TFG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFG
genes like me logo Genes that share disorders with TFG: view

No data available for Genatlas for TFG Gene

Publications for TFG Gene

  1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PMID: 9169129) Mencinger M. … Aman P. (Genomics 1997) 2 3 4 22 65
  2. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. (PMID: 23479643) Beetz C. … Audhya A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 4 65
  3. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. (PMID: 7565764) Greco A. … Pierotti M.A. (Mol. Cell. Biol. 1995) 3 4 22 65
  4. The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement. (PMID: 22883144) Ishiura H. … Tsuji S. (Am. J. Hum. Genet. 2012) 3 4 65
  5. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. (PMID: 19797732) Chase A. … Cross N.C. (Haematologica 2010) 3 22 65

Products for TFG Gene

Sources for TFG Gene

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