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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFG Gene

protein-coding   GIFtS: 63
GCID: GC03P100428

TRK-Fused Gene

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRK-Fused Gene1 2     TF62
TRK-Fused Gene Protein2 3     TRKT32
HMSNP2     Protein TFG2
SPG572     TRKT3 Oncogene2

External Ids:    HGNC: 117581   Entrez Gene: 103422   Ensembl: ENSG000001143547   OMIM: 6024985   UniProtKB: Q927343   

Export aliases for TFG gene to outside databases

Previous GC identifers: GC03P097099 GC03P099713 GC03P101709 GC03P101749 GC03P101910 GC03P097796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFG Gene:
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in
several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role
in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. (provided by RefSeq, Sep
2010)

GeneCards Summary for TFG Gene: 
TFG (TRK-fused gene) is a protein-coding gene. Diseases associated with TFG include spastic paraplegia-optic atrophy-neuropathy syndrome, and chondrosarcoma. GO annotations related to this gene include identical protein binding and signal transducer activity.

Gene Wiki entry for TFG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFG gene promoter:
         AP-1   COUP   NF-kappaB   HNF-1A   COUP-TF   HNF-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFG promoter sequence
   Search SABiosciences Chromatin IP Primers for TFG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2   Ensembl cytogenetic band:  3q12.2   HGNC cytogenetic band: 3q12.2

TFG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P100428:  view genomic region     (about GC identifiers)

Start:
100,428,134 bp from pter      End:
100,467,811 bp from pter
Size:
39,678 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734 (See protein sequence)
Recommended Name: Protein TFG  
Size: 400 amino acids; 43448 Da
Secondary accessions: D3DN49 G5E9V1 Q15656 Q969I2
Alternative splicing: 2 isoforms:  Q92734-1   Q92734-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TFG: NX_Q92734

Explore proteomics data for TFG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92734

  • TFG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFG Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001007566.1  NP_001182407.1  NP_001182408.1  NP_006061.2  

    ENSEMBL proteins: 
     ENSP00000397182   ENSP00000419960   ENSP00000240851   ENSP00000419559   ENSP00000417952  
     ENSP00000419504   ENSP00000420797  

    Human Recombinant Protein Products for TFG: 
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    Novus Biologicals TFG Proteins
    Novus Biologicals TFG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFG 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS7565764

    TFG for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TFG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000270 OPR_PB1

    Graphical View of Domain Structure for InterPro Entry Q92734

    ProtoNet protein and cluster: Q92734

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p


    TFG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TFG:
    TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IEA--
         
    TFG for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFG:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Tfg (no phenotypes)

    TFG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFG 

    miRNA
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    miRTarBase miRNAs that target TFG:
    hsa-mir-192 (MIRT004131)

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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TFG:
    hsa-miR-142-3p hsa-miR-133a hsa-miR-889 hsa-miR-4255 hsa-miR-133b hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidTFG 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TFG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TFG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Thyroid cancer
    Thyroid cancer
    2Pathways in cancer
    Pathways in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for TFG):
        Pathways in cancer
    Thyroid cancer


    TFG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/97 Interacting proteins for TFG (Q927341, 2, 3 ENSP000002408514) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48424 MINT-48458 I2D: score=2 
    ARL15Q9NXU52, 3MINT-64619 I2D: score=4 
    C14orf1Q9UKR52, 3MINT-65102 I2D: score=4 
    KIAA1377Q9P2H02, 3MINT-65101 I2D: score=4 
    CRMP1Q141942, 3MINT-65097 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0008219cell death IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IMP12761501

    TFG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFG

    1 Novoseek inferred chemical compound relationship for TFG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 30.5 2 12584559 (1), 12237775 (1)

    Search CenterWatch for drugs/clinical trials and news about TFG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFG gene (4 alternative transcripts): 
    NM_001007565.2  NM_001195478.1  NM_001195479.1  NM_006070.5  

    Unigene Cluster for TFG:

    TRK-fused gene
    Hs.518123  [show with all ESTs]
    Unigene Representative Sequence: NM_006070
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418917(uc003duf.3) ENST00000490574 ENST00000240851(uc003due.3 uc003dug.3 uc003dui.3)
    ENST00000479672 ENST00000476228 ENST00000463568 ENST00000487505 ENST00000481203


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFG
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TFG:
    hsa-miR-142-3p hsa-miR-133a hsa-miR-889 hsa-miR-4255 hsa-miR-133b hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidTFG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TFG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFG
    Clone
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    OriGene clones in human, mouse for TFG (see all 16)
    OriGene ORF clones in mouse, rat for TFG
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    GenScript: all cDNA clones in your preferred vector (see all 4): TFG (NM_001007565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFG
    Sirion Biotech Customized lentivirus for stable overexpression of TFG 
                         Customized lentivirus expression plasmids for stable overexpression of TFG 
    Primer
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    OriGene qPCR primer pairs and template standards for TFG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFG

    Additional mRNA sequence: 

    AB097040.1 AB097041.1 AB731569.1 AB731570.1 AK093456.1 AY532911.1 BC001483.2 BC009241.2 
    BC023599.2 BC041600.1 BT007428.1 CR456781.1 Y07968.1 

    24/36 DOTS entries (see all 36):

    DT.100883627  DT.448313  DT.97869198  DT.91783534  DT.100883664  DT.95079028  DT.91783472  DT.91869171 
    DT.120847756  DT.101971600  DT.101985164  DT.40127456  DT.422962  DT.120847657  DT.120847769  DT.91783471 
    DT.100883666  DT.120847648  DT.92385321  DT.100883619  DT.120847767  DT.100883623  DT.100883626  DT.100883628 

    24/723 AceView cDNA sequences (see all 723):

    CB132078 CR619391 BE301872 BM840651 BF433359 BI818595 AA737400 BG214993 
    AA975925 BM837749 AW196201 CB152510 BQ679700 BG184283 CD518668 CB131320 
    AI671585 BG199820 AI075856 AI244672 BX363341 CA420436 BU782651 AI924781 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TFG (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
    SP1:                                                        -     -     -     -     -                                                                           
    SP2:                                                  -     -     -     -     -     -                                                                           
    SP3:                          -     -     -     -     -     -     -     -     -     -                                                                           
    SP4:                          -     -     -     -     -     -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 10b ^ 11 ^ 12
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:  -               
    SP5:  -               


    ECgene alternative splicing isoforms for TFG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFG expression in normal human tissues (normalized intensities)      TFG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTACTAAA
    TFG Expression
    About this image


    TFG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Brain (Nervous System)
             Cerebral Cortex

    See TFG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFG

    SOURCE GeneReport for Unigene cluster: Hs.518123

    UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TFG: 
              Neurotrophins & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TFG gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfg1 , 5 Trk-fused gene1, 5 90.82(n)1
    94.7(a)1
      16 (34.22 cM)5
    217871  NM_019678.31  NP_062652.11 
     566903325 
    chicken
    (Gallus gallus)
    Aves TFG1 TRK-fused gene 77.12(n)
    84.58(a)
      418391  XM_416608.3  XP_416608.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFG6
    TRK-fused gene
    84(a)
    1 ↔ 1
    3(174079907-174100253)
    African clawed frog
    (Xenopus laevis)
    Amphibia tfg-prov2 Trk-fused gene 77.04(n)    BC044079.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11c102 wufb11c10 75.41(n)   336466  BC047167.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tfg-11 Protein TFG-1 40.88(n)
    32.4(a)
      173277  NM_061061.4  NP_493462.1 


    ENSEMBL Gene Tree for TFG (if available)
    TreeFam Gene Tree for TFG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFG gene
    2 SIMAP similar genes for TFG using alignment to 7 protein entries:     TFG_HUMAN (see all proteins):
    TFG-NR4A3 fusion    TFG/ALK fusion

    TFG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TFG
    PGOHUM00000243611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/966 SNPs in TFG are shown (see all 966)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356684
    A colorectal cancer sample4--see VAR_0356682 A S mis40--------
    VAR_0689174
    Hereditary motor and sensory neuropathy, proximal type (HMSNP)4--see VAR_0689172 P L mis40--------
    rs2074822301,2
    Cpathogenic1100434300(+) ACAACC/TTCAGC 8 P L mis10--------
    VAR_0597314
    ----see VAR_0597312 V F mis40--------
    rs1415804091,2
    --97796552(+) CCTCGC/TTCGAA 4 -- int10--------
    rs30571941,2
    C--97815061(+) aaata-/ATA   
      T
    /TTTA
    AGAAC
    4 -- int12NA 4
    rs716255671,2
    C--97816273(+) AACTCTTA/-TTATT 4 -- int11Minor allele frequency- -:0.50NA 2
    rs105371721,2
    C--97824772(+) AAGCC-/A/AA  
            
    AAAAA
    4 -- int12NA CSA 4
    rs636700601,2
    --97834026(-) AAAAAA/GGGATT 4 -- int10--------
    rs58512201,2
    C--97835893(+) GACATAAAC/-  
            
    AAACA
    4 -- ds50011Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for TFG (100428134 - 100467811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TFG:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv183e55CNV Gain17911159
    esv2751970CNV Gain17911159
    nsv516418CNV Gain19592680
    nsv470794CNV Gain18288195
    dgv613n27CNV Gain19166990
    dgv614n27CNV Gain19166990
    nsv877220CNV Gain21882294
    dgv182e55CNV Gain17911159
    nsv460787CNV Gain19166990


    Human Gene Mutation Database (HGMD): TFG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TFG
    DNA2.0 Custom Variant and Variant Library Synthesis for TFG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602498   
    OMIM disorders: 612237  
    UniProtKB/Swiss-Prot: TFG_HUMAN, Q92734
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in
    disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas.
    Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3
    (TRK-T3) fusion transcript
  • Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder
    characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations,
    with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles
    amyotrophic lateral sclerosis. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 15 diseases for TFG:    About MalaCards
    spastic paraplegia-optic atrophy-neuropathy syndrome    chondrosarcoma    extraskeletal myxoid chondrosarcoma    myxoid chondrosarcoma
    anaplastic large cell lymphoma    papillary carcinoma    papillary thyroid carcinoma    thyroid cancer
    thyroiditis    amyotrophic lateral sclerosis    lateral sclerosis    ischemia
    neuropathy    gastric cancer    melanoma


    TFG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for TFG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 66 2 9169129 (1), 10092511 (1)
    anaplastic large cell lymphoma 63.4 1 10556217 (1)
    lymphoma 30 2 19797732 (2)
    tumors 0 3 19797732 (2), 12584559 (1)

    Genetic Association Database (GAD): TFG

    Export disorders for TFG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFG gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with TFG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PubMed id 9169129)1, 2, 3, 9 Mencinger M....Aman P. (1997)
    2. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. (PubMed id 7565764)1, 2, 9 Greco A....Pierotti M.A. (1995)
    3. Inhibition of TFG function causes hereditary axon dege neration by impairing endoplasmic reticulum structure. (PubMed id 23479643)1, 3 Beetz C....Audhya A. (2013)
    4. The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement. (PubMed id 22883144)1, 2 Ishiura H.... Tsuji S. (2012)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. (PubMed id 15557341)1, 9 Roccato E....Greco A. (2005)
    7. Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. (PubMed id 12237775)1, 9 Roccato E....Greco A. (2002)
    8. Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. (PubMed id 11943732)1, 9 Hernandez L....Campo E. (2002)
    9. TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. (PubMed id 10556217)1, 9 Hernandez L....Campo E. (1999)
    10. TFG, a target of chromosome translocations in lymphom a and soft tissue tumors, fuses to GPR128 in healthy individuals. (PubMed id 19797732)1, 9 Chase A....Cross N.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10342 HGNC: 11758 AceView: TFG Ensembl:ENSG00000114354 euGenes: HUgn10342
    ECgene: TFG Kegg: 10342 H-InvDB: TFG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFG gene:
    Search GeneIP for patents involving TFG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     Regulatory tfbs in TFG promoter
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