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Aliases for TFG Gene

Aliases for TFG Gene

  • TRK-Fused Gene 2 3
  • TRK-Fused Gene Protein 3 4
  • TRKT3 Oncogene 3
  • HMSNP 3
  • SPG57 3
  • TRKT3 3
  • TF6 3

External Ids for TFG Gene

Previous GeneCards Identifiers for TFG Gene

  • GC03P097099
  • GC03P099713
  • GC03P101709
  • GC03P101749
  • GC03P101910
  • GC03P100428
  • GC03P097796

Summaries for TFG Gene

Entrez Gene Summary for TFG Gene

  • There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for TFG Gene

TFG (TRK-Fused Gene) is a Protein Coding gene. Diseases associated with TFG include hereditary motor and sensory neuropathy, okinawa type and spastic paraplegia 57, autosomal recessive. Among its related pathways are Pathways in cancer and Transport to the Golgi and subsequent modification. GO annotations related to this gene include identical protein binding and signal transducer activity.

UniProtKB/Swiss-Prot for TFG Gene

  • Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Wiki entry for TFG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFG Gene

Genomics for TFG Gene

Regulatory Elements for TFG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TFG Gene

100,709,284 bp from pter
100,748,967 bp from pter
39,684 bases
Plus strand

Genomic View for TFG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFG Gene

Proteins for TFG Gene

  • Protein details for TFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TFG
    Protein Accession:
    Secondary Accessions:
    • D3DN49
    • G5E9V1
    • K0J5S8
    • K0J6K2
    • Q15656
    • Q969I2

    Protein attributes for TFG Gene

    400 amino acids
    Molecular mass:
    43448 Da
    Quaternary structure:
    • Self-associates to form an oligomeric complex.

    Alternative splice isoforms for TFG Gene


neXtProt entry for TFG Gene

Proteomics data for TFG Gene at MOPED

Post-translational modifications for TFG Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TFG Gene

Domains & Families for TFG Gene

Protein Domains for TFG Gene


Suggested Antigen Peptide Sequences for TFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PB1 domain.
  • Contains 1 PB1 domain.
genes like me logo Genes that share domains with TFG: view

No data available for Gene Families for TFG Gene

Function for TFG Gene

Molecular function for TFG Gene

GENATLAS Biochemistry:
TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma
UniProtKB/Swiss-Prot Function:
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.

Gene Ontology (GO) - Molecular Function for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TFG: view
genes like me logo Genes that share phenotypes with TFG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TFG Gene

Localization for TFG Gene

Subcellular locations from

Jensen Localization Image for TFG Gene COMPARTMENTS Subcellular localization image for TFG gene
Compartment Confidence
extracellular 5
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm NAS 7565764
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TFG Gene

Pathways & Interactions for TFG Gene

genes like me logo Genes that share pathways with TFG: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for TFG Gene


Gene Ontology (GO) - Biological Process for TFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007165 signal transduction IMP 12761501
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with TFG: view

Drugs & Compounds for TFG Gene

(1) Drugs for TFG Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547
genes like me logo Genes that share compounds with TFG: view

Transcripts for TFG Gene

Unigene Clusters for TFG Gene

TRK-fused gene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -

ExUns: 10b ^ 11 ^ 12
SP4: -
SP5: -

Relevant External Links for TFG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFG Gene

mRNA expression in normal human tissues for TFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFG Gene

This gene is overexpressed in Bone marrow stromal cell (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFG Gene

SOURCE GeneReport for Unigene cluster for TFG Gene Hs.518123

mRNA Expression by UniProt/SwissProt for TFG Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with TFG: view

Protein tissue co-expression partners for TFG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TFG Gene

Orthologs for TFG Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TFG 35
  • 92.5 (n)
  • 95 (a)
-- 36
  • 91 (a)
TFG 36
  • 95 (a)
(Canis familiaris)
Mammalia TFG 35
  • 93.67 (n)
  • 95.25 (a)
TFG 36
  • 95 (a)
(Mus musculus)
Mammalia Tfg 35
  • 88.38 (n)
  • 91.16 (a)
Tfg 16
Tfg 36
  • 94 (a)
(Pan troglodytes)
Mammalia TFG 35
  • 99.58 (n)
  • 100 (a)
TFG 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC102546978 35
  • 88.41 (n)
  • 91.18 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
-- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TFG 36
  • 89 (a)
(Gallus gallus)
Aves TFG 35
  • 73.69 (n)
  • 79.18 (a)
TFG 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TFG 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2241 35
tfg 35
  • 71.04 (n)
  • 75.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia tfg-prov 35
(Danio rerio)
Actinopterygii tfg 35
  • 62.14 (n)
  • 63.45 (a)
wufb11c10 35
tfg 36
  • 66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3867 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for TFG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFG Gene

Gene Tree for TFG (if available)
Gene Tree for TFG (if available)

Paralogs for TFG Gene

(2) SIMAP similar genes for TFG Gene using alignment to 7 proteins: Pseudogenes for TFG Gene

genes like me logo Genes that share paralogs with TFG: view

No data available for Paralogs for TFG Gene

Variants for TFG Gene

Sequence variations from dbSNP and Humsavar for TFG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7297 -- 100,748,832(-) CACCC(A/T)AGCAT utr-variant-3-prime
rs11353 -- 100,748,174(+) GGACC(C/T)CAACA synonymous-codon, reference
rs12562 -- 100,736,589(+) AGTGC(G/T)CCTGC synonymous-codon, reference
rs186920 -- 100,732,261(+) CAAAA(A/G)GAGGT intron-variant
rs186956 -- 100,740,715(-) ACACA(C/G)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFG Gene

Variant ID Type Subtype PubMed ID
dgv182e55 CNV Gain 17911159
dgv613n27 CNV Gain 19166990
nsv516418 CNV Gain 19592680
nsv877220 CNV Gain 21882294
esv2751970 CNV Gain 17911159
dgv183e55 CNV Gain 17911159
dgv614n27 CNV Gain 19166990
nsv470794 CNV Gain 18288195
nsv460787 CNV Gain 19166990

Variation tolerance for TFG Gene

Residual Variation Intolerance Score: 56.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFG Gene

Disorders for TFG Gene

MalaCards: The human disease database

(14) MalaCards diseases for TFG Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hereditary motor and sensory neuropathy, okinawa type
  • neuropathy, hereditary motor and sensory, okinawa type
spastic paraplegia 57, autosomal recessive
  • autosomal recessive spastic paraplegia type 57
laryngeal benign neoplasm
  • laryngeal tumor
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
extraosseous chondrosarcoma
  • extraskeletal myxoid chondrosarcoma
- elite association
Search TFG in MalaCards View complete list of genes associated with diseases


  • Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. {ECO:0000269 PubMed:22883144}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. {ECO:0000269 PubMed:23479643}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.

Relevant External Links for TFG

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TFG: view

No data available for Genatlas for TFG Gene

Publications for TFG Gene

  1. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (PMID: 9169129) Mencinger M. … Aman P. (Genomics 1997) 2 23 67
  2. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. (PMID: 23479643) Beetz C. … Audhya A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 67
  3. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. (PMID: 19797732) Chase A. … Cross N.C. (Haematologica 2010) 23 67
  4. Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma. (PMID: 17627253) BrzeziaA8ska E. … LewiA8ski A. (Neuro Endocrinol. Lett. 2007) 23 67
  5. Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. (PMID: 15557341) Roccato E. … Greco A. (J. Biol. Chem. 2005) 23 67

Products for TFG Gene

Sources for TFG Gene

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