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Aliases for TFF3 Gene

Aliases for TFF3 Gene

  • Trefoil Factor 3 (Intestinal) 2 3
  • ITF 3 4 6
  • Polypeptide P1.B 3 4
  • TFI 3 4
  • Intestinal Trefoil Factor 4
  • Trefoil Factor 3 3
  • HP1.B 4
  • HITF 4
  • P1B 3

External Ids for TFF3 Gene

Previous GeneCards Identifiers for TFF3 Gene

  • GC21M040279
  • GC21M042626
  • GC21M042605
  • GC21M043726
  • GC21M029149

Summaries for TFF3 Gene

Entrez Gene Summary for TFF3 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF3 Gene

TFF3 (Trefoil Factor 3 (Intestinal)) is a Protein Coding gene. Diseases associated with TFF3 include autosomal recessive nonsyndromic deafness and corneal disease. Among its related pathways are IL4-mediated signaling events and HIF-1-alpha transcription factor network. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot for TFF3 Gene

  • Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Gene Wiki entry for TFF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF3 Gene

Genomics for TFF3 Gene

Regulatory Elements for TFF3 Gene

Genomic Location for TFF3 Gene

Start:
42,311,667 bp from pter
End:
42,315,651 bp from pter
Size:
3,985 bases
Orientation:
Minus strand

Genomic View for TFF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF3 Gene

Proteins for TFF3 Gene

  • Protein details for TFF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07654-TFF3_HUMAN
    Recommended name:
    Trefoil factor 3
    Protein Accession:
    Q07654
    Secondary Accessions:
    • E9PBB5
    • Q96NX0
    • Q9UDA5

    Protein attributes for TFF3 Gene

    Size:
    80 amino acids
    Molecular mass:
    8641 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAH17859.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL28111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA95531.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13731.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TFF3 Gene

neXtProt entry for TFF3 Gene

Proteomics data for TFF3 Gene at MOPED

Post-translational modifications for TFF3 Gene

No Post-translational modifications

Other Protein References for TFF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for TFF3 Gene

Domains for TFF3 Gene

Protein Domains for TFF3 Gene

Suggested Antigen Peptide Sequences for TFF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07654

UniProtKB/Swiss-Prot:

TFF3_HUMAN :
  • Q07654
Domain:
  • Contains 1 P-type (trefoil) domain.
genes like me logo Genes that share domains with TFF3: view

No data available for Gene Families for TFF3 Gene

Function for TFF3 Gene

Molecular function for TFF3 Gene

GENATLAS Biochemistry:
intestinal trefoil factor 3,expressed in the goblet cells of small,may be involved in mitogenic processes,cell adhesion migration by controling the expression of APC and E-cadherin-catenin complexes
UniProtKB/Swiss-Prot Function:
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Gene Ontology (GO) - Molecular Function for TFF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TFF3: view
genes like me logo Genes that share phenotypes with TFF3: view

Animal Models for TFF3 Gene

MGI Knock Outs for TFF3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TFF3 Gene

Localization for TFF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF3 Gene

Secreted, extracellular space, extracellular matrix. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFF3 Gene COMPARTMENTS Subcellular localization image for TFF3 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TFF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 8454642
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IEA --
GO:0030141 secretory granule --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFF3: view

Pathways for TFF3 Gene

genes like me logo Genes that share pathways with TFF3: view

Pathways by source for TFF3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TFF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 8454642
GO:0007586 digestion TAS 8454642
GO:0043434 response to peptide hormone --
genes like me logo Genes that share ontologies with TFF3: view

Compounds for TFF3 Gene

(26) Novoseek inferred chemical compound relationships for TFF3 Gene

Compound -log(P) Hits PubMed IDs
dextran sulfate sodium 50.7 2
trinitrobenzenesulfonic acid 31.5 1
phosphoinositide 26 1
butyrate 25.3 8
parathion 22 2
genes like me logo Genes that share compounds with TFF3: view

Transcripts for TFF3 Gene

mRNA/cDNA for TFF3 Gene

Unigene Clusters for TFF3 Gene

Trefoil factor 3 (intestinal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFF3 Gene

No ASD Table

Relevant External Links for TFF3 Gene

GeneLoc Exon Structure for
TFF3
ECgene alternative splicing isoforms for
TFF3

Expression for TFF3 Gene

mRNA expression in normal human tissues for TFF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFF3 Gene

This gene is overexpressed in Colon - Transverse (19.9), Thyroid (12.9), and Small Intestine - Terminal Ileum (7.6).

Protein differential expression in normal tissues for TFF3 Gene

This gene is overexpressed in Cervix (22.4), Oral epithelium (19.8), and Urine (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TFF3 Gene

SOURCE GeneReport for Unigene cluster for TFF3 Gene Hs.82961

mRNA Expression by UniProt/SwissProt for TFF3 Gene

Q07654-TFF3_HUMAN
Tissue specificity: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).
genes like me logo Genes that share expressions with TFF3: view

Expression partners for TFF3 Gene

In Situ Assay Products

Orthologs for TFF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TFF3 35
  • 85.83 (n)
  • 80 (a)
TFF3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFF3 35
  • 77.92 (n)
  • 65 (a)
TFF3 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tff3 35
  • 74.58 (n)
  • 70 (a)
Tff3 16
Tff3 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TFF3 35
  • 99.29 (n)
  • 97.87 (a)
TFF3 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tff3 35
  • 75.14 (n)
  • 76.27 (a)
oppossum
(Monodelphis domestica)
Mammalia TFF3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFF3 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFF2 35
  • 56.1 (n)
  • 50 (a)
lizard
(Anolis carolinensis)
Reptilia TFF3 36
  • 58 (a)
OneToOne
Species with no ortholog for TFF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF3 Gene

ENSEMBL:
Gene Tree for TFF3 (if available)
TreeFam:
Gene Tree for TFF3 (if available)

Paralogs for TFF3 Gene

Paralogs for TFF3 Gene

Selected SIMAP similar genes for TFF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TFF3: view

Variants for TFF3 Gene

Sequence variations from dbSNP and Humsavar for TFF3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs225360 -- 42,313,821(+) TAAAT(A/G)CTCAG intron-variant
rs225361 -- 42,314,874(+) TTGCT(A/G)TGCAA intron-variant
rs225362 -- 42,317,025(+) GACCC(A/G)TGGGA upstream-variant-2KB
rs225363 -- 42,317,264(+) AGCAG(C/G)ATTTT upstream-variant-2KB
rs225439 -- 42,311,295(+) GCCCC(A/G)GCAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TFF3 Gene

Variant ID Type Subtype PubMed ID
nsv913779 CNV Loss 21882294
nsv510799 CNV Loss 20534489
nsv913783 CNV Loss 21882294
nsv913788 CNV Loss 21882294
dgv4748n71 CNV Loss 21882294

Relevant External Links for TFF3 Gene

HapMap Linkage Disequilibrium report
TFF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFF3 Gene

Disorders for TFF3 Gene

(2) University of Copenhagen DISEASES for TFF3 Gene

(37) Novoseek inferred disease relationships for TFF3 Gene

Disease -log(P) Hits PubMed IDs
thyroid follicular carcinoma 68.1 4
colitis 52.2 9
metaplasia 51.8 11
adenoma follicular 47.7 5
gastric cancer 42.5 17

Relevant External Links for TFF3

Genetic Association Database (GAD)
TFF3
Human Genome Epidemiology (HuGE) Navigator
TFF3
genes like me logo Genes that share disorders with TFF3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TFF3 Gene

Publications for TFF3 Gene

  1. Characterization of human and rat intestinal trefoil factor produced in yeast. (PMID: 7718582) Thim L. … Podolsky D.K. (Biochemistry 1995) 2 3 23
  2. Identification of human intestinal trefoil factor. Goblet cell- specific expression of a peptide targeted for apical secretion. (PMID: 8454642) Podolsky D.K. … Mahida Y.R. (J. Biol. Chem. 1993) 3 4 23
  3. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. (PMID: 14690424) Muskett F.W. … Feeney J. (Biochemistry 2003) 3 4 23
  4. TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. (PMID: 15515157) Hawthorn L. … Tan D. (Head Neck 2004) 3 23
  5. Ontogeny and prenatal expression of trefoil factor 3/ITF in the human intestine. (PMID: 12663147) Lin J. … Babyatsky M.W. (Early Hum. Dev. 2003) 3 23

Products for TFF3 Gene

Sources for TFF3 Gene

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