TFF3 Gene

Aliases
for TFF3 gene

Previous GC identifers: GC21M040279 GC21M042626 GC21M042605 GC21M029149

Summaries
for TFF3 gene

Genomic Views
for TFF3 gene

Proteins
for TFF3 gene

2 PDB 3D structures from and Proteopedia for TFF3:

1E9T (3D)        1PE3 (3D)    

Explore the universe of human proteins at neXtProt for TFF3: NX_Q07654

TFF3 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TFF3 OriGene Custom Protein Services for TFF3
	GenScript Purified and Recombinant Proteins for TFF3
	Novus Biologicals TFF3 Proteins
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	ProSpec Recombinant Protein for TFF3
	Uscn Proteins for TFF3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for TFF3
	OriGene Antibodies (see all 2): TFF3 OriGene Custom Antibody Services for TFF3
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	Novus Biologicals TFF3 Antibodies
	Abcam antibodies for TFF3
	Uscn Antibodies for TFF3
	ThermoFisher Antibodies for TFF3

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TFF3         (see all)
	GenScript Custom Assay Services for TFF3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TFF3

Protein Domains /
Families
for TFF3 gene

ProtoNet protein and cluster: Q07654

Function
for TFF3 gene

miRNA Products:		OriGene 3'-UTR Clone: TFF3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TFF3:
		hsa-miR-641 hsa-miR-3617 hsa-miR-412
		SwitchGear 3'UTR luciferase reporter plasmid: TFF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFF3 (see all 7) OriGene shRNA RFP: TFF3 OriGene siRNA: TFF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TFF3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFF3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFF3 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TFF3 (NM_003226)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TFF3
		Search LifeMap BioReagents cell lines for TFF3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Tff3)

Pathways & Interactions
for TFF3 gene

	Super-pathway	contained gene-specific pathways
1	HIF-1-alpha transcription factor network	HIF-1-alpha transcription factor network 1.00
2	IL4-mediated signaling events	IL4-mediated signaling events 1.00

2 BioSystems Pathways for TFF3

	HIF-1-alpha transcription factor network
	IL4-mediated signaling events

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TFF3 gene

Transcripts
for TFF3 gene

Expression
for TFF3 gene

TFF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCACCCGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver LobulePeriportal Hepatocytes			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
	N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
	Midbrain dopaminergic-like neurons (Generation of midbra...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3

Orthologs
for TFF3 gene

Paralogs
for TFF3 gene

Paralogs for TFF3 gene

TFF1²  TFF2²  

2 SIMAP similar genes for TFF3 using alignment to 2 protein entries:     TFF3_HUMAN (see all proteins):

TFF2    TFF1

TFF3 for paralogs           About GeneDecksing

Genomic Variants
for TFF3 gene

10/155 NCBI SNPs in TFF3 are shown (see all 155)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1393926221,2		--	43731373(+)	TGCAGC/TGGAAT	1	--	ds5001		0	--	--	--	--
rs2254391,2	C,F,H,	--	43731405(+)	GCCCCG/AGCAGT	1	--	ds5001		24		NS EA NA WA CSA	2333
rs1436009521,2	C,	--	43731433(+)	CCCAG-/GCAGGCAGCGCT CACAGGAGGCCCAAGCAGG	1	--	ds5001		0	--	--	--	--
rs112031931,2	C,F,H	--	43731458(+)	GCCCAG/AGCAGG	1	--	ds5001		4		NA WA CSA	7
rs112031941,2	C,A,H	--	43731459(+)	CCCAAC/GCAGGC	1	--	ds5001		0	--	--	--	--
rs112031951,2	C,H,	--	43731485(+)	CCCAGG/CCAGGC	1	--	ds5001		3		WA NA EA	242
rs1455779361,2		--	43731589(+)	CAGTGC/TGATGG	1	--	ds5001		0	--	--	--	--
rs744550111,2		--	43731595(+)	GATGGG/AGAGAG	1	--	ds5001		2		CSA WA	120
rs1477071381,2		--	43731696(+)	CATCCA/GTTTTT	1	--	ds5001		0	--	--	--	--
rs769694631,2		--	43731781(+)	GTGCCT/AGTTTG	1	--	ut31		2		CSA WA	120

HapMap Linkage Disequilibrium report for TFF3 (43731777 - 43735761 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TFF3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFF3

DNA2.0 Custom Variant and Variant Library Synthesis for TFF3

Disorders / Diseases
for TFF3 gene

20/45 diseases for TFF3

10/37 Novoseek disease relationships for TFF3 gene (see all 37)    About this table

Publications
for TFF3 gene

PubMed articles for TFF3 gene, integrated from 9 sources (see all 239): (articles sorted by number of sources associating them with TFF3)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of human and rat intestinal trefoil factor produced in yeast. (PubMed id 7718582)^{1, 3, 9} Thim L....Podolsky D.K. (1995)
2. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. (PubMed id 14690424)^{1, 2, 9} Muskett F.W.... Feeney J. (2003)
3. Identification of human intestinal trefoil factor. Goblet cell- specific expression of a peptide targeted for apical secretion. (PubMed id 8454642)^{1, 2, 9} Podolsky D.K.... Mahida Y.R. (1993)
4. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PubMed id 9070946)^{1, 2, 9} Seib T.... Welter C. (1997)
5. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)^{1, 3, 9} Gott P....Blin N. (1996)
6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs. (PubMed id 14637006)^{1, 2} Casadei R....Zannotti M. (2003)
9. The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
10. Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. (PubMed id 10950923)^{1, 2} Berry A.... Bonne-Tamir B. (2000)

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