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Aliases for TFF3 Gene

Aliases for TFF3 Gene

  • Trefoil Factor 3 2 3 5
  • Trefoil Factor 3 (Intestinal) 2 3
  • Polypeptide P1.B 3 4
  • ITF 3 4
  • TFI 3 4
  • Intestinal Trefoil Factor 4
  • HP1.B 4
  • HITF 4
  • P1B 3

External Ids for TFF3 Gene

Previous GeneCards Identifiers for TFF3 Gene

  • GC21M040279
  • GC21M042626
  • GC21M042605
  • GC21M043726
  • GC21M029149

Summaries for TFF3 Gene

Entrez Gene Summary for TFF3 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF3 Gene

TFF3 (Trefoil Factor 3) is a Protein Coding gene. Diseases associated with TFF3 include colitis and thyroid cancer, nonmedullary, 2. Among its related pathways are HIF-1-alpha transcription factor network and IL4-mediated signaling events. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot for TFF3 Gene

  • Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Gene Wiki entry for TFF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF3 Gene

Genomics for TFF3 Gene

Regulatory Elements for TFF3 Gene

Genomic Location for TFF3 Gene

42,311,667 bp from pter
42,315,651 bp from pter
3,985 bases
Minus strand

Genomic View for TFF3 Gene

Genes around TFF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF3 Gene

Proteins for TFF3 Gene

  • Protein details for TFF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trefoil factor 3
    Protein Accession:
    Secondary Accessions:
    • E9PBB5
    • Q96NX0
    • Q9UDA5

    Protein attributes for TFF3 Gene

    80 amino acids
    Molecular mass:
    8641 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked.
    • Sequence=AAH17859.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL28111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA95531.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13731.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TFF3 Gene

neXtProt entry for TFF3 Gene

Proteomics data for TFF3 Gene at MOPED

Post-translational modifications for TFF3 Gene

No Post-translational modifications

Other Protein References for TFF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TFF3 Gene

Domains & Families for TFF3 Gene

Protein Domains for TFF3 Gene

Suggested Antigen Peptide Sequences for TFF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 P-type (trefoil) domain.
  • Contains 1 P-type (trefoil) domain.
genes like me logo Genes that share domains with TFF3: view

No data available for Gene Families for TFF3 Gene

Function for TFF3 Gene

Molecular function for TFF3 Gene

GENATLAS Biochemistry:
intestinal trefoil factor 3,expressed in the goblet cells of small,may be involved in mitogenic processes,cell adhesion migration by controling the expression of APC and E-cadherin-catenin complexes
UniProtKB/Swiss-Prot Function:
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
genes like me logo Genes that share phenotypes with TFF3: view

Animal Models for TFF3 Gene

MGI Knock Outs for TFF3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TFF3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TFF3 Gene

Localization for TFF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF3 Gene

Secreted, extracellular space, extracellular matrix. Cytoplasm.

Subcellular locations from

Jensen Localization Image for TFF3 Gene COMPARTMENTS Subcellular localization image for TFF3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TFF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFF3: view

Pathways & Interactions for TFF3 Gene

genes like me logo Genes that share pathways with TFF3: view

Pathways by source for TFF3 Gene

Gene Ontology (GO) - Biological Process for TFF3 Gene


No data available for SIGNOR curated interactions for TFF3 Gene

Drugs & Compounds for TFF3 Gene

(11) Drugs for TFF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for TFF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFF3: view

Transcripts for TFF3 Gene

mRNA/cDNA for TFF3 Gene

Unigene Clusters for TFF3 Gene

Trefoil factor 3 (intestinal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFF3 Gene

No ASD Table

Relevant External Links for TFF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFF3 Gene

mRNA expression in normal human tissues for TFF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFF3 Gene

This gene is overexpressed in Colon - Transverse (x19.9), Thyroid (x12.9), and Small Intestine - Terminal Ileum (x7.6).

Protein differential expression in normal tissues from HIPED for TFF3 Gene

This gene is overexpressed in Cervix (22.4), Oral epithelium (19.8), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TFF3 Gene

SOURCE GeneReport for Unigene cluster for TFF3 Gene Hs.82961

mRNA Expression by UniProt/SwissProt for TFF3 Gene

Tissue specificity: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).
genes like me logo Genes that share expression patterns with TFF3: view

Protein tissue co-expression partners for TFF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TFF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TFF3 35
  • 85.83 (n)
  • 80 (a)
TFF3 36
  • 79 (a)
(Canis familiaris)
Mammalia TFF3 35
  • 77.92 (n)
  • 65 (a)
TFF3 36
  • 63 (a)
(Mus musculus)
Mammalia Tff3 35
  • 74.58 (n)
  • 70 (a)
Tff3 16
Tff3 36
  • 67 (a)
(Pan troglodytes)
Mammalia TFF3 35
  • 99.29 (n)
  • 97.87 (a)
TFF3 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Tff3 35
  • 75.14 (n)
  • 76.27 (a)
(Monodelphis domestica)
Mammalia TFF3 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TFF3 36
  • 56 (a)
(Gallus gallus)
Aves TFF2 35
  • 56.1 (n)
  • 50 (a)
(Anolis carolinensis)
Reptilia TFF3 36
  • 58 (a)
Species with no ortholog for TFF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF3 Gene

Gene Tree for TFF3 (if available)
Gene Tree for TFF3 (if available)

Paralogs for TFF3 Gene

Paralogs for TFF3 Gene

(2) SIMAP similar genes for TFF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TFF3: view

Variants for TFF3 Gene

Sequence variations from dbSNP and Humsavar for TFF3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs225360 -- 42,313,821(+) TAAAT(A/G)CTCAG intron-variant
rs225361 -- 42,314,874(+) TTGCT(A/G)TGCAA intron-variant
rs225362 -- 42,317,025(+) GACCC(A/G)TGGGA upstream-variant-2KB
rs225363 -- 42,317,264(+) AGCAG(C/G)ATTTT upstream-variant-2KB
rs225439 -- 42,311,295(+) GCCCC(A/G)GCAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TFF3 Gene

Variant ID Type Subtype PubMed ID
nsv913779 CNV Loss 21882294
nsv510799 CNV Loss 20534489
nsv913783 CNV Loss 21882294
nsv913788 CNV Loss 21882294
dgv4748n71 CNV Loss 21882294

Variation tolerance for TFF3 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFF3 Gene

Disorders for TFF3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TFF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer, nonmedullary, 2
  • thyroid carcinoma, follicular, somatic
gastrointestinal adenoma
  • gi adenoma
colorectal cancer
  • colorectal cancer, somatic
thyroid cancer, monmedullary, 1
  • papillary thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TFF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TFF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFF3 Gene

Publications for TFF3 Gene

  1. Characterization of human and rat intestinal trefoil factor produced in yeast. (PMID: 7718582) Thim L. … Podolsky D.K. (Biochemistry 1995) 2 3 23 67
  2. Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. (PMID: 20063012) Rinnert M. … Hoffmann W. (Cell Tissue Res. 2010) 3 23
  3. Trefoil factor 3 (TFF3): a promising indicator for diagnosing thyroid follicular carcinoma. (PMID: 18506086) Takano T. … Yamada H. (Endocr. J. 2009) 3 23
  4. Trefoil factor-3 expression in human colon cancer liver metastasis. (PMID: 18979216) Babyatsky M. … Itzkowitz S. (Clin. Exp. Metastasis 2009) 3 23
  5. Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. (PMID: 19528408) Patel M.R. … Zanation A.M. (Arch. Otolaryngol. Head Neck Surg. 2009) 3 23

Products for TFF3 Gene

Sources for TFF3 Gene

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