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TFF3 Gene

protein-coding   GIFtS: 60
GCID: GC21M043726

Trefoil Factor 3 (Intestinal)

  See TFF3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Trefoil Factor 3 (Intestinal)1 2     P1B2
ITF2 3 5     Trefoil Factor 32
Polypeptide P1.B2 3     hITF3
TFI2 3     hP1.B3
Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11     Intestinal Trefoil Factor3

External Ids:    HGNC: 117571   Entrez Gene: 70332   Ensembl: ENSG000001601807   OMIM: 6006335   UniProtKB: Q076543   
ORGUL members:         

Export aliases for TFF3 gene to outside databases

Previous GC identifers: GC21M040279 GC21M042626 GC21M042605 GC21M029149


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFF3 Gene:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid
domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal
mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer
and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This
gene and two other related trefoil family member genes are found in a cluster on chromosome 21. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TFF3 Gene:
TFF3 (trefoil factor 3 (intestinal)) is a protein-coding gene. Diseases associated with TFF3 include autosomal recessive nonsyndromic deafness, and corneal disease. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Function: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial
cells in healing processes (motogen)

Gene Wiki entry for TFF3 (Trefoil factor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFF3 gene promoter:
         C/EBPbeta   PPAR-gamma1   Tal-1   Sp1   STAT3   PPAR-gamma2   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFF3 promoter sequence

   Search Chromatin IP Primers for TFF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M043726:   GeneLoc Nature:405,311-319
Start:
43,731,777 bp from pter       29,279,510 bp from centromere
End:
43,735,761 bp from pter 29,282,789 bp from centromere
Size:
3,985 bases 3,280 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: L08044
genomic clones: KB169B4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654 (See protein sequence)
Recommended Name: Trefoil factor 3 precursor  
Size: 80 amino acids; 8641 Da
Subunit: Monomer. Homodimer; disulfide-linked
Sequence caution: Sequence=AAH17859.1; Type=Erroneous initiation; Sequence=AAL28111.1; Type=Erroneous initiation;
Sequence=BAA95531.1; Type=Erroneous initiation; Sequence=BAB13731.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TFF3:
1E9T (3D)        1PE3 (3D)    
Secondary accessions: E9PBB5 Q96NX0 Q9UDA5
Alternative splicing: 2 isoforms:  Q07654-1   Q07654-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TFF3: NX_Q07654

Explore proteomics data for TFF3 at MOPED


See TFF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003217.3  
ENSEMBL proteins: 
 ENSP00000430690   ENSP00000381462   ENSP00000291525  

TFF3 Human Recombinant Protein Products:

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Novus Biologicals TFF3 Proteins
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Cloud-Clone Corp. Proteins for TFF3

 
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LSBio Antibodies in human, mouse, rat for TFF3

TFF3 Assay Products:

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Cloud-Clone Corp. CLIAs for TFF3
Search eBioscience for ELISAs for TFF3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR000519 P_trefoil
 IPR017994 P_trefoil_chordata
 IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry Q07654

ProtoNet protein and cluster: Q07654

1 Blocks protein domain: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Similarity: Contains 1 P-type (trefoil) domain


Find genes that share domains with TFF3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFF3_HUMAN, Q07654
Function: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial
cells in healing processes (motogen)

     Genatlas biochemistry entry for TFF3:
intestinal trefoil factor 3,expressed in the goblet cells of small,may be involved in mitogenic processes,cell
adhesion migration by controling the expression of APC and E-cadherin-catenin complexes

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TFF3           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tff3):
 digestive/alimentary  homeostasis/metabolism  immune system 

Find genes that share phenotypes with TFF3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Tff3tm1Dkpy for TFF3

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFF3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFF3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFF3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFF3

miRNA
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3 qRT-PCR Assays for microRNAs that regulate TFF3:
hsa-miR-641 hsa-miR-3617 hsa-miR-412
SwitchGear 3'UTR luciferase reporter plasmidTFF3 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for TFF3
Predesigned siRNA for gene silencing in human, mouse, rat TFF3

Gene Editing
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GenScript: all cDNA clones in your preferred vector: TFF3 (NM_003226)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TFF3_HUMAN, Q07654: Secreted, extracellular space, extracellular matrix, apical lamina
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
endoplasmic reticulum1
lysosome1
mitochondrion1
nucleus1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS8454642
GO:0030141secretory granule IEA--
GO:0032579apical lamina of hyaline layer IEA--

Find genes that share ontologies with TFF3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TFF3 About    
See pathways by source

SuperPathContained pathways About
1IL4-mediated signaling events
IL4-mediated signaling events
2HIF-1-alpha transcription factor network
HIF-1-alpha transcription factor network


2 BioSystems Pathways for TFF3
    IL4-mediated signaling events
HIF-1-alpha transcription factor network


    Pathway & Disease-focused RT2 Profiler PCR Arrays including TFF3: 
          Breast Cancer in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for TFF3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for TFF3 (Q076543 ENSP000002915254) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MUC3AQ025053I2D: score=1 
ARNTENSP000003514074STRING: ENSP00000351407
HIF1AENSP000003380184STRING: ENSP00000338018
STAT6ENSP000003001344STRING: ENSP00000300134
TCF3ENSP000002629654STRING: ENSP00000262965
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response TAS8454642
GO:0007586digestion TAS8454642
GO:0043434response to peptide hormone IEA--

Find genes that share ontologies with TFF3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TFF3

Selected Novoseek inferred chemical compound relationships for TFF3 gene (see all 26)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dextran sulfate sodium 50.7 3 9260328 (1), 15825079 (1)
trinitrobenzenesulfonic acid 31.5 1 15825079 (1)
phosphoinositide 26 1 19758246 (1)
butyrate 25.3 17 16254517 (5), 9655688 (2), 17849419 (1)
parathion 22 2 14691392 (1), 16142316 (1)
indomethacin 18.1 2 15298624 (1), 8566596 (1)
pd 98,059 16.3 1 10220499 (1)
estrogen 16.2 5 9737246 (2), 12792801 (1), 17624412 (1), 17077188 (1)
pge2 12.4 9 10825288 (3), 12360478 (2)
tamoxifen 11.8 4 9306961 (1)



Find genes that share compounds with TFF3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TFF3 gene: 
NM_003226.3  

Unigene Cluster for TFF3:

Trefoil factor 3 (intestinal)
Hs.82961  [show with all ESTs]
Unigene Representative Sequence: BU536516
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000518498 ENST00000489676 ENST00000398431 ENST00000291525(uc002zav.3)

miRNA
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3 qRT-PCR Assays for microRNAs that regulate TFF3:
hsa-miR-641 hsa-miR-3617 hsa-miR-412
SwitchGear 3'UTR luciferase reporter plasmidTFF3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TFF3
Predesigned siRNA for gene silencing in human, mouse, rat TFF3
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OriGene ORF clones in mouse, rat for TFF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TFF3 (NM_003226)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TFF3
OriGene qSTAR qPCR primer pairs in human, mouse for TFF3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFF3
  QuantiTect SYBR Green Assays in human, mouse, rat TFF3
  QuantiFast Probe-based Assays in human, mouse, rat TFF3

Additional mRNA sequence: 

AF432265.1 BC017859.1 L08044.1 L15203.1 

5 DOTS entries:

DT.448500  DT.121134528  DT.92419294  DT.95170588  DT.75175891 

Selected AceView cDNA sequences (see all 125):

W95643 BM743413 AI350070 AA384655 AW167728 AI347277 AA384635 BQ129284 
BM856919 NM_003226 BM850935 AI460270 BQ129159 AA327546 AA558976 AI143630 
AF432265 AW291863 BM272747 AA314975 BM708674 AW007096 AI973212 AI346752 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TFF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCCACCCGA
TFF3 Expression
About this image


TFF3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         N2/LSB/S/F8/CHIR-induced cells
 
 Ovary (Reproductive System)
         Oviduct
 
 Liver (Hepatobiliary System)
         Periportal Hepatocytes Liver Lobule
 
 Neurons
         Midbrain dopaminergic-like neurons
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
TFF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TFF3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.82961

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Tissue specificity: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet
cells of small and large intestinal epithelia and also by the uterus

    Pathway & Disease-focused RT2 Profiler PCR Arrays including TFF3: 
          Breast Cancer in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TFF3
OriGene qSTAR qPCR primer pairs in human, mouse for TFF3
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QuantiTect SYBR Green Assays in human, mouse, rat TFF3
QuantiFast Probe-based Assays in human, mouse, rat TFF3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TFF3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tff31 , 5 trefoil factor 3, intestinal1, 5 74.58(n)1
70(a)1
  17 (15.80 cM)5
217861  NM_011575.21  NP_035705.11 
 311253065 
chicken
(Gallus gallus)
Aves TFF21 trefoil factor 2 56.1(n)
50(a)
  418534  XM_004934583.1  XP_004934640.1 
lizard
(Anolis carolinensis)
Reptilia TFF36
trefoil factor 3 (intestinal)
58(a)
1 ↔ 1
3(137815628-137815762)


ENSEMBL Gene Tree for TFF3 (if available)
TreeFam Gene Tree for TFF3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TFF3 gene
TFF12  TFF22  
2 SIMAP similar genes for TFF3 using alignment to 2 protein entries:     TFF3_HUMAN (see all proteins):
TFF2    TFF1

Find genes that share paralogs with TFF3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TFF3 (see all 204)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1393926221,2
--43731373(+) TGCAGC/TGGAAT 1 -- ds50010--------
rs2254391,2
C,F,H--43731405(+) GCCCCG/AGCAGT 1 -- ds500124Minor allele frequency- A:0.46NS EA NA WA CSA 2333
rs1436009521,2
C--43731433(+) CCCAG-/GCAGGCAGCGCT
CACAGGAGGCCCAA
GCAGG
1 -- ds50010--------
rs112031931,2
C,F,H--43731458(+) GCCCAG/AGCAGG 1 -- ds50014Minor allele frequency- A:0.43NA WA CSA 7
rs112031941,2
C,A,H--43731459(+) CCCAAC/GCAGGC 1 -- ds50010--------
rs112031951,2
C,H--43731485(+) CCCAGG/CCAGGC 1 -- ds50013Minor allele frequency- C:0.27WA NA EA 242
rs1455779361,2
--43731589(+) CAGTGC/TGATGG 1 -- ds50010--------
rs744550111,2
C,F--43731595(+) GATGGG/AGAGAG 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
rs1477071381,2
--43731696(+) CATCCA/GTTTTT 1 -- ds50010--------
rs769694631,2
C,F--43731781(+) GTGCCT/AGTTTG 1 -- ut312Minor allele frequency- A:0.04CSA WA 120

HapMap Linkage Disequilibrium report for TFF3 (43731777 - 43735761 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TFF3:    About this table    
Variant IDTypeSubtypePubMed ID
dgv4748n71CNV Loss21882294
nsv913788CNV Loss21882294
nsv913783CNV Loss21882294
nsv913779CNV Loss21882294
nsv510799CNV Loss20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TFF3
DNA2.0 Custom Variant and Variant Library Synthesis for TFF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600633    OMIM disorders: --

6 diseases for TFF3:    
About MalaCards
autosomal recessive nonsyndromic deafness    corneal disease    papillary thyroid carcinoma    colon cancer
lung cancer    prostate cancer

2 diseases from the University of Copenhagen DISEASES database for TFF3:
Gastroenteritis     Inflammatory bowel disease

Find genes that share disorders with TFF3           About GenesLikeMe

Selected Novoseek inferred disease relationships for TFF3 gene (see all 37)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid follicular carcinoma 68.1 8 19528408 (1), 18302262 (1), 18506086 (1), 15694668 (1)
colitis 52.2 14 12912861 (2), 15825079 (2), 19238529 (2), 17455148 (1) (see all 6)
metaplasia 51.8 13 12210076 (3), 15177872 (2), 11310832 (2), 12006524 (1) (see all 7)
adenoma follicular 47.7 8 19528408 (2), 18198227 (1), 15083192 (1), 15694668 (1)
gastric cancer 42.5 21 12006524 (5), 15769482 (5), 12168114 (4), 10639160 (1) (see all 6)
colon cancer 41.8 28 18979216 (6), 16086236 (2), 9655688 (2), 12522107 (1) (see all 7)
thyroid papillary carcinoma 40.9 6 19528408 (2), 18154116 (1), 15515157 (1)
carcinoma 37.8 27 15083192 (3), 19528408 (2), 15845533 (2), 18198227 (1) (see all 10)
gastric tumor 36.4 1 12477053 (1)
adenoma 35.1 11 17455148 (2), 17851679 (1), 17639052 (1), 15083192 (1) (see all 5)

Genetic Association Database (GAD): TFF3
Human Genome Epidemiology (HuGE) Navigator: TFF3 (5 documents)

Export disorders for TFF3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TFF3 gene, integrated from 10 sources (see all 252):
(articles sorted by number of sources associating them with TFF3)
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  1. Characterization of human and rat intestinal trefoil factor produced in yeast. (PubMed id 7718582)1, 3, 9 Thim L....Podolsky D.K. (Biochemistry 1995)
  2. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. (PubMed id 14690424)1, 2, 9 Muskett F.W.... Feeney J. (Biochemistry 2003)
  3. Identification of human intestinal trefoil factor. Goblet cell- specific expression of a peptide targeted for apical secretion. (PubMed id 8454642)1, 2, 9 Podolsky D.K.... Mahida Y.R. (J. Biol. Chem. 1993)
  4. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PubMed id 9070946)1, 2, 9 Seib T.... Welter C. (Genomics 1997)
  5. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)1, 3, 9 GAPtt P....Blin N. (Eur. J. Hum. Genet. 1996)
  6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
  7. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
  8. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
  9. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
  10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7033 HGNC: 11757 AceView: TFF3 Ensembl:ENSG00000160180 euGenes: HUgn7033
ECgene: TFF3 H-InvDB: TFF3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TFF3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFF3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TFF3 gene:
Search GeneIP for patents involving TFF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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