Aliases for TFF3 Gene
External Ids for TFF3 Gene
Previous GeneCards Identifiers for TFF3 Gene
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for TFF3 Gene
TFF3 (Trefoil Factor 3 (Intestinal)) is a Protein Coding gene. Diseases associated with TFF3 include autosomal recessive nonsyndromic deafness and corneal disease. Among its related pathways are IL4-mediated signaling events and HIF-1-alpha transcription factor network. An important paralog of this gene is TFF1.
UniProtKB/Swiss-Prot for TFF3 Gene
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).