Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFF3 Gene

protein-coding   GIFtS: 61
GCID: GC21M043726

Trefoil Factor 3 (Intestinal)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Trefoil Factor 3 (Intestinal)1 2     P1B2
ITF2 3 5     Trefoil Factor 32
Polypeptide P1.B2 3     hITF3
TFI2 3     hP1.B3
Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11     Intestinal Trefoil Factor3

External Ids:    HGNC: 117571   Entrez Gene: 70332   Ensembl: ENSG000001601807   OMIM: 6006335   UniProtKB: Q076543   
ORGUL members:         

Export aliases for TFF3 gene to outside databases

Previous GC identifers: GC21M040279 GC21M042626 GC21M042605 GC21M029149


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFF3 Gene:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid
domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal
mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer
and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This
gene and two other related trefoil family member genes are found in a cluster on chromosome 21. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TFF3 Gene: 
TFF3 (trefoil factor 3 (intestinal)) is a protein-coding gene. Diseases associated with TFF3 include perinatal necrotizing enterocolitis, and autosomal recessive nonsyndromic deafness. GO annotations related to this gene include molecular_function. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Function: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial
cells in healing processes (motogen)

Gene Wiki entry for TFF3 (Trefoil factor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFF3 gene promoter:
         C/EBPbeta   PPAR-gamma1   Tal-1   Sp1   STAT3   PPAR-gamma2   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFF3 promoter sequence

   Search SABiosciences Chromatin IP Primers for TFF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TFF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF3 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M043726:   GeneLoc Nature:405,311-319
Start:
43,731,777 bp from pter       29,279,510 bp from centromere
End:
43,735,761 bp from pter 29,282,789 bp from centromere
Size:
3,985 bases 3,280 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: L08044
genomic clones: KB169B4


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654 (See protein sequence)
Recommended Name: Trefoil factor 3 precursor  
Size: 80 amino acids; 8641 Da
Subunit: Monomer. Homodimer; disulfide-linked
Subcellular location: Secreted, extracellular space, extracellular matrix, apical lamina
Sequence caution: Sequence=AAH17859.1; Type=Erroneous initiation; Sequence=AAL28111.1; Type=Erroneous initiation;
Sequence=BAA95531.1; Type=Erroneous initiation; Sequence=BAB13731.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TFF3:
1E9T (3D)        1PE3 (3D)    
Secondary accessions: E9PBB5 Q96NX0 Q9UDA5
Alternative splicing: 2 isoforms:  Q07654-1   Q07654-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TFF3: NX_Q07654

Explore proteomics data for TFF3 at MOPED 

TFF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TFF3 Protein Expression

REFSEQ proteins: NP_003217.3  
ENSEMBL proteins: 
 ENSP00000430690   ENSP00000381462   ENSP00000291525  

Human Recombinant Protein Products for TFF3: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for TFF3
OriGene Custom MassSpec 
OriGene Custom Protein Services for TFF3
GenScript Purified and Recombinant Proteins for TFF3
Novus Biologicals TFF3 Proteins
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for TFF3
Cloud-Clone Corp. Proteins for TFF3 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS8454642
GO:0030141secretory granule IEA--
GO:0032579apical lamina of hyaline layer IEA--

TFF3 for ontologies           About GeneDecksing



TFF3 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for TFF3
OriGene Antibodies for TFF3
OriGene Custom Antibody Services for TFF3
GenScript Custom Superior Antibodies Services for TFF3
Novus Biologicals TFF3 Antibodies
Abcam antibodies for TFF3
Cloud-Clone Corp. Antibodies for TFF3 
ThermoFisher Antibodies for TFF3
LSBio Antibodies in human, mouse, rat for TFF3 

Assay Products for TFF3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TFF3
R&D Systems ELISAs for TFF3         (see all)
GenScript Custom Assay Services for TFF3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TFF3 
Cloud-Clone Corp. CLIAs for TFF3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR000519 P_trefoil
 IPR017994 P_trefoil_chordata
 IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry Q07654

ProtoNet protein and cluster: Q07654

1 Blocks protein domain: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Similarity: Contains 1 P-type (trefoil) domain


TFF3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFF3_HUMAN, Q07654
Function: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial
cells in healing processes (motogen)

     Genatlas biochemistry entry for TFF3:
intestinal trefoil factor 3,expressed in the goblet cells of small,may be involved in mitogenic processes,cell
adhesion migration by controling the expression of APC and E-cadherin-catenin complexes

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
TFF3 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tff3):
 digestive/alimentary  homeostasis/metabolism  immune system 

TFF3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tff3tm1Dkpy for TFF3

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TFF3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFF3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFF3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFF3 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF3
3 QIAGEN miScript miRNA Assays for microRNAs that regulate TFF3:
hsa-miR-641 hsa-miR-3617 hsa-miR-412
SwitchGear 3'UTR luciferase reporter plasmidTFF3 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TFF3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TFF3
Sirion Biotech Customized adenovirus for overexpression of TFF3

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for TFF3 (see all 9)
OriGene ORF clones in mouse, rat for TFF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TFF3 (NM_003226)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3
Sirion Biotech Customized lentivirus for stable overexpression of TFF3 
                     Customized lentivirus expression plasmids for stable overexpression of TFF3 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TFF3
Search LifeMap BioReagents cell lines for TFF3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TFF3 About                                                                                                See pathways by source

SuperPathContained pathways About
1HIF-1-alpha transcription factor network
HIF-1-alpha transcription factor network
2IL4-mediated signaling events
IL4-mediated signaling events


2 BioSystems Pathways for TFF3
    HIF-1-alpha transcription factor network
IL4-mediated signaling events


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFF3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for TFF3 (Q076543 ENSP000002915254) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MUC3AQ025053I2D: score=1 
ARNTENSP000003514074STRING: ENSP00000351407
HIF1AENSP000003380184STRING: ENSP00000338018
STAT6ENSP000003001344STRING: ENSP00000300134
TCF3ENSP000002629654STRING: ENSP00000262965
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response TAS8454642
GO:0007586digestion TAS8454642
GO:0043434response to peptide hormone stimulus IEA--

TFF3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TFF3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFF3

10/26 Novoseek inferred chemical compound relationships for TFF3 gene (see all 26)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dextran sulfate sodium 50.7 3 9260328 (1), 15825079 (1)
trinitrobenzenesulfonic acid 31.5 1 15825079 (1)
phosphoinositide 26 1 19758246 (1)
butyrate 25.3 17 16254517 (5), 9655688 (2), 17849419 (1)
parathion 22 2 14691392 (1), 16142316 (1)
indomethacin 18.1 2 15298624 (1), 8566596 (1)
pd 98,059 16.3 1 10220499 (1)
estrogen 16.2 5 9737246 (2), 12792801 (1), 17624412 (1), 17077188 (1)
pge2 12.4 9 10825288 (3), 12360478 (2)
tamoxifen 11.8 4 9306961 (1)

Search CenterWatch for drugs/clinical trials and news about TFF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TFF3 gene: 
NM_003226.3  

Unigene Cluster for TFF3:

Trefoil factor 3 (intestinal)
Hs.82961  [show with all ESTs]
Unigene Representative Sequence: BU536516
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000518498 ENST00000489676 ENST00000398431 ENST00000291525(uc002zav.3)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF3
3 QIAGEN miScript miRNA Assays for microRNAs that regulate TFF3:
hsa-miR-641 hsa-miR-3617 hsa-miR-412
SwitchGear 3'UTR luciferase reporter plasmidTFF3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TFF3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF3
Clone
Products:
     
OriGene clones in human, mouse for TFF3 (see all 9)
OriGene ORF clones in mouse, rat for TFF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TFF3 (NM_003226)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3
Sirion Biotech Customized lentivirus for stable overexpression of TFF3 
                     Customized lentivirus expression plasmids for stable overexpression of TFF3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TFF3
OriGene qSTAR qPCR primer pairs in human, mouse for TFF3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFF3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF3

Additional mRNA sequence: 

AF432265.1 BC017859.1 L08044.1 L15203.1 

5 DOTS entries:

DT.448500  DT.121134528  DT.92419294  DT.95170588  DT.75175891 

24/125 AceView cDNA sequences (see all 125):

AA384655 BQ129284 AW167728 BQ129159 BM856919 AA558976 AA384635 AW291863 
W95643 BM272747 AF432265 BM850935 AI143630 AA327546 NM_003226 AI350070 
BM743413 AI347277 AI460270 BI114257 AI748945 AI332337 AW176584 BQ016069 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TFF3 expression in normal human tissues (normalized intensities)      TFF3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCCACCCGA
TFF3 Expression
About this image


TFF3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/18 selected tissues (see all 18) fully expand
 
 Endothelium (Cardiovascular System)    fully expand to see all 4 entries
         Human Cardiac Microvascular Endothelial Cells (HCMEC)   
 
 Intestine
         small intestine ; glandular cells   
 
 Liver (Hepatobiliary System)    fully expand to see all 2 entries
         Periportal Hepatocytes Liver Lobule
         Human Hepatic Sinusoidal Endothelial Cells (HHSEC)   
 
 Brain (Nervous System)    fully expand to see all 2 entries
         N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
 
 Colon (Gastrointestinal Tract)
         rectum ; glandular cells   

See TFF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFF3

SOURCE GeneReport for Unigene cluster: Hs.82961

UniProtKB/Swiss-Prot: TFF3_HUMAN, Q07654
Tissue specificity: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet
cells of small and large intestinal epithelia and also by the uterus

    SABiosciences Expression via Pathway-Focused PCR Arrays including TFF3: 
          Breast Cancer in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TFF3
OriGene qSTAR qPCR primer pairs in human, mouse for TFF3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFF3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TFF3 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tff31 , 5 trefoil factor 3, intestinal1, 5 71.25(n)1
67.5(a)1
  17 (15.80 cM)5
217861  NM_011575.21  NP_035705.11 
 311253065 
lizard
(Anolis carolinensis)
Reptilia TFF36
trefoil factor 3 (intestinal)
58(a)
1 ↔ 1
3(137815628-137815762)


ENSEMBL Gene Tree for TFF3 (if available)
TreeFam Gene Tree for TFF3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TFF3 gene
TFF12  TFF22  
2 SIMAP similar genes for TFF3 using alignment to 2 protein entries:     TFF3_HUMAN (see all proteins):
TFF2    TFF1

TFF3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/204 SNPs in TFF3 are shown (see all 204)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1393926221,2
--43731373(+) TGCAGC/TGGAAT 1 -- ds50010--------
rs2254391,2
C,F,H--43731405(+) GCCCCG/AGCAGT 1 -- ds500124Minor allele frequency- A:0.46NS EA NA WA CSA 2333
rs1436009521,2
C--43731433(+) CCCAG-/GCAGGCAGCGCT
CACAGGAGGCCCAA
GCAGG
1 -- ds50010--------
rs112031931,2
C,F,H--43731458(+) GCCCAG/AGCAGG 1 -- ds50014Minor allele frequency- A:0.43NA WA CSA 7
rs112031941,2
C,A,H--43731459(+) CCCAAC/GCAGGC 1 -- ds50010--------
rs112031951,2
C,H--43731485(+) CCCAGG/CCAGGC 1 -- ds50013Minor allele frequency- C:0.27WA NA EA 242
rs1455779361,2
--43731589(+) CAGTGC/TGATGG 1 -- ds50010--------
rs744550111,2
C,F--43731595(+) GATGGG/AGAGAG 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
rs1477071381,2
--43731696(+) CATCCA/GTTTTT 1 -- ds50010--------
rs769694631,2
C,F--43731781(+) GTGCCT/AGTTTG 1 -- ut312Minor allele frequency- A:0.04CSA WA 120

HapMap Linkage Disequilibrium report for TFF3 (43731777 - 43735761 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TFF3:    About this table     
Variant IDTypeSubtypePubMed ID
dgv4748n71CNV Loss21882294
nsv913788CNV Loss21882294
nsv913783CNV Loss21882294
nsv913779CNV Loss21882294
nsv510799CNV Loss20534489

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TFF3
DNA2.0 Custom Variant and Variant Library Synthesis for TFF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600633    OMIM disorders: --

20/41 diseases for TFF3 (see all 41):    About MalaCards
perinatal necrotizing enterocolitis    autosomal recessive nonsyndromic deafness    pterygium    nonsyndromic deafness
corneal disease    gastric ulcer    barrett's esophagus    papillary thyroid carcinoma
acute graft versus host disease    gastroenteritis    primary biliary cirrhosis    small cell carcinoma
graft versus host disease    lung adenocarcinoma    papillary carcinoma    colon cancer
gastric cancer    ulcerative colitis    hypoxia    hepatocellular carcinoma

2 diseases from the University of Copenhagen DISEASES database for TFF3:
Gastroenteritis     Inflammatory bowel disease

TFF3 for disorders           About GeneDecksing

10/37 Novoseek inferred disease relationships for TFF3 gene (see all 37)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid follicular carcinoma 68.1 8 19528408 (1), 18302262 (1), 18506086 (1), 15694668 (1)
colitis 52.2 14 12912861 (2), 15825079 (2), 19238529 (2), 17455148 (1) (see all 6)
metaplasia 51.8 13 12210076 (3), 15177872 (2), 11310832 (2), 12006524 (1) (see all 7)
adenoma follicular 47.7 8 19528408 (2), 18198227 (1), 15083192 (1), 15694668 (1)
gastric cancer 42.5 21 12006524 (5), 15769482 (5), 12168114 (4), 10639160 (1) (see all 6)
colon cancer 41.8 28 18979216 (6), 16086236 (2), 9655688 (2), 12522107 (1) (see all 7)
thyroid papillary carcinoma 40.9 6 19528408 (2), 18154116 (1), 15515157 (1)
carcinoma 37.8 27 15083192 (3), 19528408 (2), 15845533 (2), 18198227 (1) (see all 10)
gastric tumor 36.4 1 12477053 (1)
adenoma 35.1 11 17455148 (2), 17851679 (1), 17639052 (1), 15083192 (1) (see all 5)

Genetic Association Database (GAD): TFF3
Human Genome Epidemiology (HuGE) Navigator: TFF3 (5 documents)

Export disorders for TFF3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TFF3 gene, integrated from 9 sources (see all 242):
(articles sorted by number of sources associating them with TFF3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of human and rat intestinal trefoil factor produced in yeast. (PubMed id 7718582)1, 3, 9 Thim L....Podolsky D.K. (1995)
  2. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. (PubMed id 14690424)1, 2, 9 Muskett F.W.... Feeney J. (2003)
  3. Identification of human intestinal trefoil factor. Goblet cell- specific expression of a peptide targeted for apical secretion. (PubMed id 8454642)1, 2, 9 Podolsky D.K.... Mahida Y.R. (1993)
  4. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PubMed id 9070946)1, 2, 9 Seib T.... Welter C. (1997)
  5. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)1, 3, 9 Gott P....Blin N. (1996)
  6. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  7. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
  8. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
  9. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
  10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7033 HGNC: 11757 AceView: TFF3 Ensembl:ENSG00000160180 euGenes: HUgn7033
ECgene: TFF3 H-InvDB: TFF3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TFF3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFF3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TFF3 gene:
Search GeneIP for patents involving TFF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for TFF3 (TFF3)   Browse Cell Culture Products  
 ELISAs for TFF3 (TFF3)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for TFF3 (TFF3)  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Proteome Profiler Antibody Arrays for TFF3 (TFF3)  
 OriGene Antibodies for TFF3   OriGene RNAi products in human, mouse, rat for TFF3  
 OriGene qPCR primer pairs and template standards for TFF3   OriGene Protein Over-expression Lysate for TFF3  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for TFF3  
 OriGene qSTAR qPCR primer pairs in human, mouse for TFF3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for TFF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TFF3   OriGene Custom Protein Services for TFF3  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TFF3
 QIAGEN SeqTarget long-range PCR primers for resequencing TFF3
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFF3
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF3
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF3
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF3
 GenScript Purified and Recombinant Proteins for TFF3 GenScript cDNA clones with any tag delivered in your preferred vector for TFF3
 GenScript Custom Assay Services for TFF3 GenScript Custom Superior Antibodies Services for TFF3
 GenScript Custom overexpressing Cell Line Services for TFF3 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in TFF3 promoter
 Search Chromatin IP Primers for TFF3
 RT2 qPCR Primer Assay in human, mouse, rat TFF3
 GNC Network for TFF3
 SABiosciences PCR Arrays including human, mouse, rat TFF3
 Search Tocris compounds for TFF3
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 TFF3 antibodies
 TFF3 proteins
 Antibodies for TFF3
 See all of Abcam's Antibodies, Kits and Proteins for TFF3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for TFF3




 Proteins for TFF3
 Antibodies for TFF3
 ELISAs for TFF3
 CLIAs for TFF3
 Search LifeMap BioReagents cell lines for TFF3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF3
 SwitchGear 3'UTR luciferase reporter plasmids for TFF3
 SwitchGear Promoter luciferase reporter plasmids for TFF3
 ThermoFisher Antibodies for TFF3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF3
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TFF3
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFF3
Customized:
 lentivirus for stable overexpression of TFF3
 lentivirus expression plasmids for stable overexpression of TFF3
 adenovirus for overexpression of TFF3
 LSBio Antibodies in human, mouse, rat for TFF3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TFF3 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4