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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFF2 Gene

protein-coding   GIFtS: 61
GCID: GC21M043766

Trefoil Factor 2

(Previous name: spasmolytic protein 1)
(Previous symbol: SML1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Trefoil Factor 21 2     SP2 3
SML11 2 3 5     Trefoil Factor 2, SML1, Human Spasmolytic Polypeptide (SP)11
Spasmolytic Protein 11 2     spasmolysin2
Spasmolytic Polypeptide2 3     Spasmolysin3

External Ids:    HGNC: 117561   Entrez Gene: 70322   Ensembl: ENSG000001601817   OMIM: 1825905   UniProtKB: Q034033   

Export aliases for TFF2 gene to outside databases

Previous GC identifers: GC21M040314 GC21M042661 GC21M042660 GC21M042639 GC21M029184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFF2 Gene:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid
domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal
mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer
and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two
other related trefoil family member genes are found in a cluster on chromosome 21. (provided by RefSeq, Jul 2008)

GeneCards Summary for TFF2 Gene: 
TFF2 (trefoil factor 2) is a protein-coding gene. Diseases associated with TFF2 include bile duct adenoma, and endocervicitis. GO annotations related to this gene include CXCR4 chemokine receptor binding and protein binding. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot: TFF2_HUMAN, Q03403
Function: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component
of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate
side chains (By similarity)

Gene Wiki entry for TFF2 (Trefoil factor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFF2 gene promoter:
         STAT1   Sp1   AP-2alpha isoform 3   AP-2alpha isoform 2   Gfi-1   SEF-1 (1)   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFF2 promoter sequence

   Search SABiosciences Chromatin IP Primers for TFF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TFF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M043766:   GeneLoc Nature:405,311-319
Start:
43,766,466 bp from pter       29,313,816 bp from centromere
End:
43,771,237 bp from pter 29,318,396 bp from centromere
Size:
4,772 bases 4,581 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: X51698
genomic clones: KB169B4


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFF2_HUMAN, Q03403 (See protein sequence)
Recommended Name: Trefoil factor 2 precursor  
Size: 129 amino acids; 14284 Da
Subcellular location: Secreted
Secondary accessions: Q15854

Explore the universe of human proteins at neXtProt for TFF2: NX_Q03403

Explore proteomics data for TFF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q03403

  • TFF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFF2 Protein Expression
    REFSEQ proteins: NP_005414.1  
    ENSEMBL proteins: 
     ENSP00000291526  

    Human Recombinant Protein Products for TFF2: 
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    OriGene Custom Protein Services for TFF2
    GenScript Purified and Recombinant Proteins for TFF2
    Novus Biologicals TFF2 Proteins
    Novus Biologicals TFF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TFF2
    Cloud-Clone Corp. Proteins for TFF2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    TFF2 for ontologies           About GeneDecksing



    TFF2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for TFF2 
    Cloud-Clone Corp. CLIAs for TFF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000519 P_trefoil
     IPR017994 P_trefoil_chordata
     IPR017957 P_trefoil_CS

    Graphical View of Domain Structure for InterPro Entry Q03403

    ProtoNet protein and cluster: Q03403

    1 Blocks protein domain: IPB000519 P-type trefoil domain

    UniProtKB/Swiss-Prot: TFF2_HUMAN, Q03403
    Similarity: Contains 2 P-type (trefoil) domains


    TFF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFF2_HUMAN, Q03403
    Function: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component
    of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate
    side chains (By similarity)

         Genatlas biochemistry entry for TFF2:
    spasmolytic protein,spasmolysin inhibitor of gastric acid secretion and spasmolytic activity in pig,overexpressed
    in gastritis ulceration,metaplasia and in some digestive tumors (stomach,pancreas,biliary tract)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031723CXCR4 chemokine receptor binding IEA--
         
    TFF2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tff2):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  immune system 

    TFF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TFF2: Tff2tm1Tcw Tff2tm1Blin

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFF2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF2
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    SwitchGear 3'UTR luciferase reporter plasmidTFF2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TFF2

    Clone
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    Sino Biological Human cDNA Clone for TFF2
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                         Customized lentivirus expression plasmids for stable overexpression of TFF2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFF2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TFF2 (Q034031, 3 ENSP000002915264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAC1P203663, ENSP000003211064I2D: score=1 STRING: ENSP00000321106
    FCRL4Q96PJ51, ENSP000002715324EBI-4314702,EBI-4314687 STRING: ENSP00000271532
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007586digestion TAS8836141
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0019722calcium-mediated signaling IEA--
    GO:0030334regulation of cell migration IEA--
    GO:0043031negative regulation of macrophage activation IEA--

    TFF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFF2

    1 DrugBank Compound for TFF2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyroglutamic Acid-- 98-79-3target--10592235

    7 Novoseek inferred chemical compound relationships for TFF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parathion 31.4 1 16142316 (1)
    aspirin 23.5 11 11163773 (4), 14759512 (2), 12792801 (1), 19741170 (1) (see all 5)
    capsaicin 8.62 1 9882597 (1)
    indomethacin 6.08 9 15298624 (5), 14759512 (2), 11163773 (1)
    arachidonic acid 0 2 11163773 (1), 12792801 (1)
    calcium 0 1 10657523 (1)
    estrogen 0 6 15177883 (3), 12792801 (1), 9737246 (1)

    Search CenterWatch for drugs/clinical trials and news about TFF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFF2 gene: 
    NM_005423.4  

    Unigene Cluster for TFF2:

    Trefoil factor 2
    Hs.2979  [show with all ESTs]
    Unigene Representative Sequence: BI517365
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291526(uc002zaw.3) ENST00000463771 ENST00000475297
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TFF2
    SwitchGear 3'UTR luciferase reporter plasmidTFF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TFF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF2
    Clone
    Products:
         
    OriGene clones in human, mouse for TFF2 (see all 6)
    OriGene ORF clones in mouse, rat for TFF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFF2 (NM_005423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF2
    Sirion Biotech Customized lentivirus for stable overexpression of TFF2 
                         Customized lentivirus expression plasmids for stable overexpression of TFF2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TFF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF2

    Additional mRNA sequence: 

    BC032820.1 X51698.1 

    1 DOTS entry:

    DT.97845589 

    24/64 AceView cDNA sequences (see all 64):

    BP341913 BM821669 BC032820 BM768552 BP343522 BM851752 BM817851 BM817810 
    BI760118 NM_005423 BM855728 BM783033 BM853882 BM782161 BM853946 AA307808 
    BM768823 BM767019 BP341850 BM767170 BM769602 BM798771 BM853896 BM768331 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TFF2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:              -                                       
    SP3:              -     -                                 


    ECgene alternative splicing isoforms for TFF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFF2 expression in normal human tissues (normalized intensities)      TFF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCCTGGG
    TFF2 Expression
    About this image


    TFF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 3 entries
             stomach, upper ; glandular cells   
             stomach cardiac   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             duodenum ; glandular cells   
             small intestine   
     
     Colon (Gastrointestinal Tract)
             rectum ; glandular cells   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

    See TFF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFF2

    SOURCE GeneReport for Unigene cluster: Hs.2979

    UniProtKB/Swiss-Prot: TFF2_HUMAN, Q03403
    Tissue specificity: Stomach

        SABiosciences Custom PCR Arrays for TFF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TFF2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tff21 , 5 trefoil factor 2 (spasmolytic protein 1)1, 5 80.36(n)1
    81.4(a)1
      17 (15.80 cM)5
    217851  NM_009363.31  NP_033389.21 
     311410495 
    chicken
    (Gallus gallus)
    Aves TFF21 trefoil factor 2 51.98(n)
    45.76(a)
      418534  XM_416743.3  XP_416743.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFF26
    trefoil factor 2
    23(a)
    1 ↔ 1
    3(137770160-137780950)


    ENSEMBL Gene Tree for TFF2 (if available)
    TreeFam Gene Tree for TFF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFF2 gene
    TFF12  TFF32  
    2 SIMAP similar genes for TFF2 using alignment to 1 protein entry:     TFF2_HUMAN:
    TFF1    TFF3

    TFF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/225 SNPs in TFF2 are shown (see all 225)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420138641,2
    --43766012(+) GCCAGC/GCATGG 1 -- ds50010--------
    rs1457775901,2
    --43766087(+) GATGTC/TAGGAG 1 -- ds50010--------
    rs1386490361,2
    --43766103(+) GACCAA/GCCTGG 1 -- ds50010--------
    rs72826691,2
    C,F,H--43766333(+) ctcacA/Gcatat 1 -- ds50015Minor allele frequency- G:0.01NS EA WA 538
    rs124836351,2
    C,F,A,H--43766377(+) ggtacA/Gcacac 1 -- ds500112Minor allele frequency- G:0.12NS EA NA CSA WA 1551
    rs124832631,2
    C,H--43766392(+) acatgG/Tgtaca 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1151381561,2
    C,F--43766397(+) GTGTGA/C/G/
            
    GTACC
    1 -- ds50012WA NA 238
    rs49200841,2
    C,F--43766482(+) TTAAGG/AGTTTT 1 -- ut314Minor allele frequency- A:0.01NA 144
    rs1483592231,2
    --43766520(+) TGAAAA/GTGAGG 1 -- ut310--------
    rs733685731,2
    C,F--43766532(+) AAAGAG/TGGTTA 1 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for TFF2 (43766466 - 43771237 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TFF2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TFF2
    DNA2.0 Custom Variant and Variant Library Synthesis for TFF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182590    OMIM disorders: --

    20/29 diseases for TFF2 (see all 29):    About MalaCards
    bile duct adenoma    endocervicitis    autosomal recessive nonsyndromic deafness    pterygium
    nonsyndromic deafness    barrett's esophagus    gastric ulcer    gastritis
    inflammatory bowel disease    gastric cancer    gastric adenocarcinoma    duodenitis
    allergic asthma    down syndrome    hypoxia    pancreatitis
    adenoma    adenocarcinoma    cholangiocarcinoma    pancreatic cancer

    2 diseases from the University of Copenhagen DISEASES database for TFF2:
    Gastritis     Gastric adenocarcinoma

    TFF2 for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for TFF2 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric polyp 69.3 2 10398119 (1), 10699992 (1)
    metaplasia 64.2 8 10190312 (3), 15300590 (1), 12717829 (1), 12210076 (1) (see all 5)
    superficial gastritis 63.8 3 15059374 (1), 16718800 (1), 12717829 (1)
    gastric cancer 62.4 30 15059374 (4), 13679442 (4), 12168114 (4), 19541923 (3) (see all 11)
    intestinal carcinoma 61 1 12210076 (1)
    gastritis atrophic 54.8 3 15059374 (1), 16718800 (1), 12717829 (1)
    inflammatory bowel diseases 41.6 1 15115253 (1)
    gastric carcinoma 41.4 9 18938748 (2), 12717829 (2), 12210076 (2), 16166422 (1) (see all 5)
    barrett esophagus 40.2 1 12152167 (1)
    pancreatic carcinoma 38.6 2 10759231 (1), 11389052 (1)

    Genetic Association Database (GAD): TFF2
    Human Genome Epidemiology (HuGE) Navigator: TFF2 (1 document)

    Export disorders for TFF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFF2 gene, integrated from 9 sources (see all 155):
    (articles sorted by number of sources associating them with TFF2)
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    1. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)1, 3, 9 Gott P....Blin N. (1996)
    2. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PubMed id 9070946)1, 2, 9 Seib T.... Welter C. (1997)
    3. The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. (PubMed id 1505966)1, 3, 9 Tomasetto C....Rio M.C. (1992)
    4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. (PubMed id 10950923)1, 2 Berry A.... Bonne-Tamir B. (2000)
    7. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. (PubMed id 2303034)1, 2 Tomasetto C....Lathe R. (1990)
    8. Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells. (PubMed id 15177880)1, 9 Chi A.L....Wang T.C. (2004)
    9. Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. (PubMed id 12717829)1, 9 Hu G.Y....Rang Z.X. (2003)
    10. Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates trefoil factor family 2 (TFF2) expression in gastric epithelial cells. (PubMed id 17118693)1, 9 Shimada T....Hiraishi H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7032 HGNC: 11756 AceView: TFF2 Ensembl:ENSG00000160181 euGenes: HUgn7032
    ECgene: TFF2 H-InvDB: TFF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFF2 gene:
    Search GeneIP for patents involving TFF2

    GeneCards and IP:
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