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Aliases for TFF2 Gene

Aliases for TFF2 Gene

  • Trefoil Factor 2 2 3 5
  • Spasmolytic Polypeptide 3 4
  • Spasmolytic Protein 1 2 3
  • Spasmolysin 3 4
  • SML1 3 4
  • SP 3 4

External Ids for TFF2 Gene

Previous HGNC Symbols for TFF2 Gene

  • SML1

Previous GeneCards Identifiers for TFF2 Gene

  • GC21M040314
  • GC21M042661
  • GC21M042660
  • GC21M042639
  • GC21M043766
  • GC21M029184

Summaries for TFF2 Gene

Entrez Gene Summary for TFF2 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF2 Gene

TFF2 (Trefoil Factor 2) is a Protein Coding gene. Diseases associated with TFF2 include Gastritis and Gastrointestinal Adenoma. GO annotations related to this gene include CXCR4 chemokine receptor binding. An important paralog of this gene is TFF3.

UniProtKB/Swiss-Prot for TFF2 Gene

  • Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Gene Wiki entry for TFF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF2 Gene

Genomics for TFF2 Gene

Regulatory Elements for TFF2 Gene

Enhancers for TFF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TFF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TFF2 Gene

42,346,357 bp from pter
42,351,128 bp from pter
4,772 bases
Minus strand

Genomic View for TFF2 Gene

Genes around TFF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF2 Gene

Proteins for TFF2 Gene

  • Protein details for TFF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trefoil factor 2
    Protein Accession:
    Secondary Accessions:
    • Q15854

    Protein attributes for TFF2 Gene

    129 amino acids
    Molecular mass:
    14284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TFF2 Gene

Proteomics data for TFF2 Gene at MOPED

Post-translational modifications for TFF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TFF2 Gene

Domains & Families for TFF2 Gene

Protein Domains for TFF2 Gene

Suggested Antigen Peptide Sequences for TFF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 P-type (trefoil) domains.
  • Contains 2 P-type (trefoil) domains.
genes like me logo Genes that share domains with TFF2: view

No data available for Gene Families for TFF2 Gene

Function for TFF2 Gene

Molecular function for TFF2 Gene

GENATLAS Biochemistry:
spasmolytic protein,spasmolysin inhibitor of gastric acid secretion and spasmolytic activity in pig,overexpressed in gastritis ulceration,metaplasia and in some digestive tumors (stomach,pancreas,biliary tract)
UniProtKB/Swiss-Prot Function:
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
genes like me logo Genes that share phenotypes with TFF2: view

Animal Models for TFF2 Gene

MGI Knock Outs for TFF2:

Animal Model Products

CRISPR Products

miRNA for TFF2 Gene

miRTarBase miRNAs that target TFF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFF2 Gene

Localization for TFF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF2 Gene


Subcellular locations from

Jensen Localization Image for TFF2 Gene COMPARTMENTS Subcellular localization image for TFF2 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for TFF2 Gene

Pathways & Interactions for TFF2 Gene

SuperPathways for TFF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TFF2 Gene

Drugs & Compounds for TFF2 Gene

(7) Drugs for TFF2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyroglutamic acid Experimental Pharma Target 0

(1) Additional Compounds for TFF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFF2: view

Transcripts for TFF2 Gene

mRNA/cDNA for TFF2 Gene

Unigene Clusters for TFF2 Gene

Trefoil factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP2: -
SP3: - -

Relevant External Links for TFF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFF2 Gene

mRNA expression in normal human tissues for TFF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFF2 Gene

This gene is overexpressed in Stomach (x52.4).

Protein differential expression in normal tissues from HIPED for TFF2 Gene

This gene is overexpressed in Pancreatic juice (44.3) and Urine (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TFF2 Gene

SOURCE GeneReport for Unigene cluster for TFF2 Gene Hs.2979

mRNA Expression by UniProt/SwissProt for TFF2 Gene

Tissue specificity: Stomach.
genes like me logo Genes that share expression patterns with TFF2: view

Protein tissue co-expression partners for TFF2 Gene

Primer Products

Orthologs for TFF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TFF2 35
  • 79.33 (n)
  • 77.52 (a)
TFF2 36
  • 78 (a)
(Canis familiaris)
Mammalia TFF2 35
  • 75.97 (n)
  • 70.54 (a)
TFF2 36
  • 60 (a)
(Mus musculus)
Mammalia Tff2 35
  • 83.33 (n)
  • 86.79 (a)
Tff2 16
Tff2 36
  • 81 (a)
(Pan troglodytes)
Mammalia TFF2 35
  • 99.74 (n)
  • 99.22 (a)
TFF2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tff2 35
  • 79.07 (n)
  • 79.07 (a)
(Monodelphis domestica)
Mammalia TFF2 36
  • 62 (a)
(Gallus gallus)
Aves TFF2 36
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
-- 36
  • 47 (a)
Species with no ortholog for TFF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF2 Gene

Gene Tree for TFF2 (if available)
Gene Tree for TFF2 (if available)

Paralogs for TFF2 Gene

Paralogs for TFF2 Gene

(2) SIMAP similar genes for TFF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFF2: view

Variants for TFF2 Gene

Sequence variations from dbSNP and Humsavar for TFF2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_053564 -
rs365821 -- 42,347,774(-) GGCCG(C/T)CCCGG intron-variant
rs4920084 -- 42,346,373(+) TTAAG(A/G)GTTTT utr-variant-3-prime
rs2839486 -- 42,348,088(+) GCGCT(C/G)GTGAA intron-variant
rs225334 -- 42,346,451(+) ATGAA(A/G)TATGA utr-variant-3-prime

Variation tolerance for TFF2 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TFF2 Gene

Disorders for TFF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TFF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute gastric mucosal erosion
gastrointestinal adenoma
  • gi adenoma
barrett esophagus/esophageal adenocarcinoma
  • esophageal cancer
- elite association - COSMIC cancer census association via MalaCards
Search TFF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TFF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFF2 Gene

Publications for TFF2 Gene

  1. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PMID: 9043862) GAPtt P. … Blin N. (Eur. J. Hum. Genet. 1996) 2 3 23 67
  2. The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. (PMID: 1505966) Tomasetto C. … Rio M.C. (Genomics 1992) 2 3 23
  3. Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. (PMID: 20063012) Rinnert M. … Hoffmann W. (Cell Tissue Res. 2010) 3 23
  4. Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. (PMID: 19064997) Dubeykovskaya Z. … Wang T.C. (J. Biol. Chem. 2009) 3 23
  5. Decreased TFF2 expression in the gastric antrum in patients infected with CagA-positive Helicobacter pylori. (PMID: 19344006) Michelis R. … Reshef R. (Isr. Med. Assoc. J. 2009) 3 23

Products for TFF2 Gene

Sources for TFF2 Gene