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Aliases for TFF2 Gene

Aliases for TFF2 Gene

  • Trefoil Factor 2 2 3 5
  • Spasmolytic Polypeptide 3 4
  • Spasmolytic Protein 1 2 3
  • Spasmolysin 3 4
  • SML1 3 4
  • SP 3 4

External Ids for TFF2 Gene

Previous HGNC Symbols for TFF2 Gene

  • SML1

Previous GeneCards Identifiers for TFF2 Gene

  • GC21M040314
  • GC21M042661
  • GC21M042660
  • GC21M042639
  • GC21M043766
  • GC21M029184

Summaries for TFF2 Gene

Entrez Gene Summary for TFF2 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF2 Gene

TFF2 (Trefoil Factor 2) is a Protein Coding gene. Diseases associated with TFF2 include Gastritis and Gastrointestinal Adenoma. GO annotations related to this gene include CXCR4 chemokine receptor binding. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot for TFF2 Gene

  • Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Gene Wiki entry for TFF2 Gene

Additional gene information for TFF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF2 Gene

Genomics for TFF2 Gene

Regulatory Elements for TFF2 Gene

Enhancers for TFF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H042231 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 +115.7 115667 7.7 HDGF PKNOX1 SIN3A FEZF1 TCF12 GLIS2 ZNF143 ZNF207 ATF7 ZNF548 ABCG1 UMODL1 PRDM15 ENSG00000233754 U2AF1 TFF2 ZBTB21 WDR4 C2CD2 UBASH3A
GH21H042457 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -110.8 -110768 8.7 HDGF FOXA2 PKNOX1 ATF1 YY1 TCF12 ZNF207 ATF7 FOS RUNX3 SLC37A1 RSPH1 ZBTB21 PRDM15 LOC101930094 ABCG1 TFF2 WDR4 UMODL1 UBASH3A
GH21H042423 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -73.7 -73669 3.6 HDGF BMI1 BATF ZNF143 ZNF207 ATF7 ETV6 RUNX3 IKZF2 CREM UMODL1 TMPRSS3 TFF1 TFF3 TFF2 ZBTB21 ABCG1 UBASH3A C2CD2 RNU6-1149P
GH21H042531 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -183.1 -183125 5 HDGF FOXA2 PKNOX1 ATF1 TBL1XR1 RB1 SIN3A BMI1 RAD21 ATF7 SLC37A1 ENSG00000235772 RSPH1 LOC101928284 TFF2 ABCG1 PKNOX1 ENSG00000231867
GH21H042448 1.6 Ensembl ENCODE dbSUPER 11.5 -98.6 -98592 2.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF143 ZNF207 FOS TMPRSS3 TFF3 TFF2 LOC101930094 SLC37A1 RSPH1 ENSG00000227698 RNU6-1149P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TFF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TFF2 Gene

Genomic Locations for TFF2 Gene
chr21:42,346,357-42,351,128
(GRCh38/hg38)
Size:
4,772 bases
Orientation:
Minus strand
chr21:43,766,466-43,771,237
(GRCh37/hg19)

Genomic View for TFF2 Gene

Genes around TFF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF2 Gene

Proteins for TFF2 Gene

  • Protein details for TFF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03403-TFF2_HUMAN
    Recommended name:
    Trefoil factor 2
    Protein Accession:
    Q03403
    Secondary Accessions:
    • Q15854

    Protein attributes for TFF2 Gene

    Size:
    129 amino acids
    Molecular mass:
    14284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TFF2 Gene

Post-translational modifications for TFF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFF2 Gene

Domains & Families for TFF2 Gene

Gene Families for TFF2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for TFF2 Gene

Suggested Antigen Peptide Sequences for TFF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TFF2: view

No data available for UniProtKB/Swiss-Prot for TFF2 Gene

Function for TFF2 Gene

Molecular function for TFF2 Gene

GENATLAS Biochemistry:
spasmolytic protein,spasmolysin inhibitor of gastric acid secretion and spasmolytic activity in pig,overexpressed in gastritis ulceration,metaplasia and in some digestive tumors (stomach,pancreas,biliary tract)
UniProtKB/Swiss-Prot Function:
Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Phenotypes From GWAS Catalog for TFF2 Gene

Gene Ontology (GO) - Molecular Function for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with TFF2: view
genes like me logo Genes that share phenotypes with TFF2: view

Animal Models for TFF2 Gene

MGI Knock Outs for TFF2:

miRNA for TFF2 Gene

miRTarBase miRNAs that target TFF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFF2 Gene

Localization for TFF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFF2 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TFF2 Gene

Pathways & Interactions for TFF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS 8836141
GO:0042060 wound healing IBA --
genes like me logo Genes that share ontologies with TFF2: view

No data available for Pathways by source and SIGNOR curated interactions for TFF2 Gene

Drugs & Compounds for TFF2 Gene

(7) Drugs for TFF2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic Acid Experimental Pharma Target 0

(1) Additional Compounds for TFF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFF2: view

Transcripts for TFF2 Gene

mRNA/cDNA for TFF2 Gene

Unigene Clusters for TFF2 Gene

Trefoil factor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - -

Relevant External Links for TFF2 Gene

GeneLoc Exon Structure for
TFF2
ECgene alternative splicing isoforms for
TFF2

Expression for TFF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TFF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFF2 Gene

This gene is overexpressed in Stomach (x52.4).

Protein differential expression in normal tissues from HIPED for TFF2 Gene

This gene is overexpressed in Pancreatic juice (44.3) and Urine (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TFF2 Gene



Protein tissue co-expression partners for TFF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TFF2 Gene:

TFF2

SOURCE GeneReport for Unigene cluster for TFF2 Gene:

Hs.2979

mRNA Expression by UniProt/SwissProt for TFF2 Gene:

Q03403-TFF2_HUMAN
Tissue specificity: Stomach.

Evidence on tissue expression from TISSUES for TFF2 Gene

  • Stomach(4.9)
  • Intestine(4.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with TFF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TFF2 Gene

Orthologs for TFF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFF2 33 34
  • 99.74 (n)
mouse
(Mus musculus)
Mammalia Tff2 33 16 34
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia TFF2 33 34
  • 79.33 (n)
rat
(Rattus norvegicus)
Mammalia Tff2 33
  • 79.07 (n)
dog
(Canis familiaris)
Mammalia TFF2 33 34
  • 75.97 (n)
oppossum
(Monodelphis domestica)
Mammalia TFF2 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFF2 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
Species where no ortholog for TFF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF2 Gene

ENSEMBL:
Gene Tree for TFF2 (if available)
TreeFam:
Gene Tree for TFF2 (if available)

Paralogs for TFF2 Gene

Paralogs for TFF2 Gene

(2) SIMAP similar genes for TFF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFF2: view

Variants for TFF2 Gene

Sequence variations from dbSNP and Humsavar for TFF2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000395550 -- 42,348,275(+) GCACT(A/G)ACATA intron-variant
rs1002532139 -- 42,348,965(+) CCCAG(A/T)CTAAC intron-variant
rs1003734794 -- 42,346,202(+) ACAAA(A/G)AAACC downstream-variant-500B
rs1003755707 -- 42,353,010(+) AGGCT(G/T)GGAAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1003843111 -- 42,347,979(+) AAATG(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFF2 Gene

Variant ID Type Subtype PubMed ID
nsv1125746 CNV tandem duplication 24896259
nsv1119498 CNV insertion 24896259

Variation tolerance for TFF2 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFF2 Gene

Disorders for TFF2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TFF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastritis
  • acute gastric mucosal erosion
gastrointestinal adenoma
  • gi adenoma
stomach cancer
  • gastric cancer
gastric cancer, somatic
  • gastric cancer
nonsyndromic deafness
  • nonsyndromic hearing loss
- elite association - COSMIC cancer census association via MalaCards
Search TFF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFF2

Genetic Association Database (GAD)
TFF2
Human Genome Epidemiology (HuGE) Navigator
TFF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFF2
genes like me logo Genes that share disorders with TFF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFF2 Gene

Publications for TFF2 Gene

  1. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PMID: 9070946) Seib T … Welter C (Genomics 1997) 3 4 22 60
  2. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PMID: 9043862) Gött P … Blin N (European journal of human genetics : EJHG 1996) 2 3 22 60
  3. The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. (PMID: 1505966) Tomasetto C … Rio MC (Genomics 1992) 2 3 22 60
  4. Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. (PMID: 20063012) Rinnert M … Hoffmann W (Cell and tissue research 2010) 3 22 60
  5. Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. (PMID: 19064997) Dubeykovskaya Z … Wang TC (The Journal of biological chemistry 2009) 3 22 60

Products for TFF2 Gene

Sources for TFF2 Gene

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