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Aliases for TFF2 Gene

Aliases for TFF2 Gene

  • Trefoil Factor 2 2 3
  • SML1 3 4 6
  • Spasmolytic Polypeptide 3 4
  • Spasmolytic Protein 1 2 3
  • Spasmolysin 3 4
  • SP 3 4

External Ids for TFF2 Gene

Previous Symbols for TFF2 Gene

  • SML1

Summaries for TFF2 Gene

Entrez Gene Summary for TFF2 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF2 Gene

TFF2 (Trefoil Factor 2) is a Protein Coding gene. Diseases associated with TFF2 include autosomal recessive nonsyndromic deafness and burns. GO annotations related to this gene include CXCR4 chemokine receptor binding. An important paralog of this gene is TFF1.

UniProtKB/Swiss-Prot for TFF2 Gene

  • Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Gene Wiki entry for TFF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF2 Gene

Genomics for TFF2 Gene

Genomic Location for TFF2 Gene

42,346,357 bp from pter
42,351,128 bp from pter
4,772 bases
Minus strand

Genomic View for TFF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF2 Gene

Proteins for TFF2 Gene

  • Protein details for TFF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trefoil factor 2
    Protein Accession:
    Secondary Accessions:
    • Q15854

    Protein attributes for TFF2 Gene

    129 amino acids
    Molecular mass:
    14284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TFF2 Gene

Proteomics data for TFF2 Gene at MOPED

Post-translational modifications for TFF2 Gene

No Post-translational modifications

Other Protein References for TFF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFF2 Gene

Domains for TFF2 Gene

Protein Domains for TFF2 Gene


  • Contains 2 P-type (trefoil) domains.:
    • Q03403
genes like me logo Genes that share domains with TFF2: view

No data available for Gene Families for TFF2 Gene

Function for TFF2 Gene

Molecular function for TFF2 Gene

GENATLAS Biochemistry: spasmolytic protein,spasmolysin inhibitor of gastric acid secretion and spasmolytic activity in pig,overexpressed in gastritis ulceration,metaplasia and in some digestive tumors (stomach,pancreas,biliary tract)
UniProtKB/Swiss-Prot Function: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Gene Ontology (GO) - Molecular Function for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0031723 CXCR4 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with TFF2: view
genes like me logo Genes that share phenotypes with TFF2: view

Animal Models for TFF2 Gene

MGI Knock Outs for TFF2:

miRNA for TFF2 Gene

miRTarBase miRNAs that target TFF2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TFF2 Gene

Localization for TFF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF2 Gene


Subcellular locations from

Jensen Localization Image for TFF2 Gene COMPARTMENTS Subcellular localization image for TFF2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TFF2: view

Pathways for TFF2 Gene

SuperPathways for TFF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS 8836141
GO:0008284 positive regulation of cell proliferation IEA --
GO:0019722 calcium-mediated signaling IEA --
GO:0030334 regulation of cell migration IEA --
GO:0043031 negative regulation of macrophage activation IEA --
genes like me logo Genes that share ontologies with TFF2: view

No data available for Pathways by source for TFF2 Gene

Compounds for TFF2 Gene

(1) Drugbank Compounds for TFF2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyroglutamic Acid
98-79-3 target

(7) Novoseek inferred chemical compound relationships for TFF2 Gene

Compound -log(P) Hits PubMed IDs
parathion 31.4 1
aspirin 23.5 9
capsaicin 8.62 1
indomethacin 6.08 8
arachidonic acid 0 2
genes like me logo Genes that share compounds with TFF2: view

Transcripts for TFF2 Gene

mRNA/cDNA for TFF2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFF2 Gene

Trefoil factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP2: -
SP3: - -

Relevant External Links for TFF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFF2 Gene

mRNA expression in normal human tissues for TFF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFF2 Gene

This gene is overexpressed in Stomach (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TFF2 Gene

SOURCE GeneReport for Unigene cluster for TFF2 Gene Hs.2979

mRNA Expression by UniProt/SwissProt for TFF2 Gene

Tissue specificity: Stomach
genes like me logo Genes that share expressions with TFF2: view

Orthologs for TFF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TFF2 36
  • 99.74 (n)
  • 99.22 (a)
TFF2 37
  • 99 (a)
(Bos Taurus)
Mammalia TFF2 36
  • 79.33 (n)
  • 77.52 (a)
TFF2 37
  • 78 (a)
(Canis familiaris)
Mammalia TFF2 36
  • 75.97 (n)
  • 70.54 (a)
TFF2 37
  • 60 (a)
(Mus musculus)
Mammalia Tff2 36
  • 83.33 (n)
  • 86.79 (a)
Tff2 16
Tff2 37
  • 81 (a)
(Monodelphis domestica)
Mammalia TFF2 37
  • 62 (a)
(Rattus norvegicus)
Mammalia Tff2 36
  • 79.07 (n)
  • 79.07 (a)
(Gallus gallus)
Aves TFF2 37
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 22 (a)
-- 37
  • 47 (a)
Species with no ortholog for TFF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF2 Gene

Gene Tree for TFF2 (if available)
Gene Tree for TFF2 (if available)

Paralogs for TFF2 Gene

Paralogs for TFF2 Gene

Selected SIMAP similar genes for TFF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFF2: view

Variants for TFF2 Gene

Sequence variations from dbSNP and Humsavar for TFF2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs225334 -- 42,346,451(+) ATGAA(A/G)TATGA utr-variant-3-prime
rs225335 -- 42,347,255(+) CTAGA(A/G)CCATC intron-variant
rs225336 -- 42,347,305(+) TTGAA(A/T)AGACG intron-variant
rs225337 -- 42,347,391(-) CTCGC(A/T)GCCTC intron-variant
rs225338 -- 42,352,323(+) TCCAG(A/G)CCCTC upstream-variant-2KB

Relevant External Links for TFF2 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for TFF2 Gene

Disorders for TFF2 Gene

(2) University of Copenhagen DISEASES for TFF2 Gene

(25) Novoseek inferred disease relationships for TFF2 Gene

Disease -log(P) Hits PubMed IDs
gastric polyp 69.3 2
metaplasia 64.2 7
superficial gastritis 63.8 3
gastric cancer 62.4 25
intestinal carcinoma 61 1

Relevant External Links for TFF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TFF2: view

No data available for UniProtKB/Swiss-Prot for TFF2 Gene

Publications for TFF2 Gene

  1. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PMID: 9043862) GAPtt P. … Blin N. (Eur. J. Hum. Genet. 1996) 2 3 23
  2. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. (PMID: 9070946) Seib T. … Welter C. (Genomics 1997) 3 4 23
  3. The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. (PMID: 1505966) Tomasetto C. … Rio M.C. (Genomics 1992) 2 3 23
  4. Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. (PMID: 12717829) Hu G.Y. … Rang Z.X. (World J. Gastroenterol. 2003) 3 23
  5. Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer. (PMID: 13679442) Dhar D.K. … Nagasue N. (Lab. Invest. 2003) 3 23

Products for TFF2 Gene

Sources for TFF2 Gene

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