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Aliases for TFF1 Gene

Aliases for TFF1 Gene

  • Trefoil Factor 1 2 3
  • BCEI 3 4 6
  • Breast Cancer Estrogen-Inducible Protein 3 4
  • Polypeptide P1.A 3 4
  • Protein PS2 3 4
  • HP1.A 3 4
  • PNR-2 3 4
  • PS2 3 4
  • Breast Cancer, Estrogen-Inducible Sequence Expressed In 2
  • Breast Cancer Estrogen-Inducible Sequence 3
  • Gastrointestinal Trefoil Protein PS2 3
  • D21S21 3
  • HPS2 3

External Ids for TFF1 Gene

Previous HGNC Symbols for TFF1 Gene

  • BCEI

Previous GeneCards Identifiers for TFF1 Gene

  • GC21M040330
  • GC21M042676
  • GC21M042655
  • GC21M043782
  • GC21M029199

Summaries for TFF1 Gene

Entrez Gene Summary for TFF1 Gene

  • Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TFF1 Gene

TFF1 (Trefoil Factor 1) is a Protein Coding gene. Diseases associated with TFF1 include bile reflux and ductal carcinoma in situ. Among its related pathways are Integrated Pancreatic Cancer Pathway and Adhesion. GO annotations related to this gene include growth factor activity. An important paralog of this gene is TFF3.

UniProtKB/Swiss-Prot for TFF1 Gene

  • Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.

Gene Wiki entry for TFF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFF1 Gene

Genomics for TFF1 Gene

Regulatory Elements for TFF1 Gene

Genomic Location for TFF1 Gene

42,362,282 bp from pter
42,366,594 bp from pter
4,313 bases
Minus strand

Genomic View for TFF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFF1 Gene

Proteins for TFF1 Gene

  • Protein details for TFF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trefoil factor 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TFF1 Gene

    84 amino acids
    Molecular mass:
    9150 Da
    Quaternary structure:
    • Heterodimer with GKN2; disulfide linked

    Three dimensional structures from OCA and Proteopedia for TFF1 Gene

neXtProt entry for TFF1 Gene

Proteomics data for TFF1 Gene at MOPED

Post-translational modifications for TFF1 Gene

No Post-translational modifications

Other Protein References for TFF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TFF1 (TFF1)

No data available for DME Specific Peptides for TFF1 Gene

Domains for TFF1 Gene

Protein Domains for TFF1 Gene

Suggested Antigen Peptide Sequences for TFF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P04155
  • Contains 1 P-type (trefoil) domain.
genes like me logo Genes that share domains with TFF1: view

No data available for Gene Families for TFF1 Gene

Function for TFF1 Gene

Molecular function for TFF1 Gene

GENATLAS Biochemistry: estrogen-inducible protein,expressed in breast cancer,and some digestive tumors (stomach,pancreas,biliary tract)
UniProtKB/Swiss-Prot Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.

Gene Ontology (GO) - Molecular Function for TFF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with TFF1: view
genes like me logo Genes that share phenotypes with TFF1: view

Animal Models for TFF1 Gene

MGI Knock Outs for TFF1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TFF1 Gene

Localization for TFF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFF1 Gene


Subcellular locations from

Jensen Localization Image for TFF1 Gene COMPARTMENTS Subcellular localization image for TFF1 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TFF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TFF1: view

Pathways for TFF1 Gene

genes like me logo Genes that share pathways with TFF1: view

Pathways by source for TFF1 Gene

1 Cell Signaling Technology pathway for TFF1 Gene
1 GeneGo (Thomson Reuters) pathway for TFF1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TFF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 2303034
GO:0007586 digestion NAS 9043862
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010039 response to iron ion IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TFF1: view

Compounds for TFF1 Gene

(1) HMDB Compounds for TFF1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(71) Novoseek inferred chemical compound relationships for TFF1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 85.3 187
progesterone 79 122
4-hydroxytamoxifen 75.9 9
tamoxifen 72.7 34
estradiol 69.5 43
genes like me logo Genes that share compounds with TFF1: view

Transcripts for TFF1 Gene

mRNA/cDNA for TFF1 Gene

(190) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFF1 Gene

Trefoil factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFF1 Gene

No ASD Table

Relevant External Links for TFF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TFF1 Gene

mRNA expression in normal human tissues for TFF1 Gene

mRNA differential expression in normal tissues according to GTEx for TFF1 Gene

This gene is overexpressed in Stomach (50.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFF1 Gene

SOURCE GeneReport for Unigene cluster for TFF1 Gene Hs.162807

mRNA Expression by UniProt/SwissProt for TFF1 Gene

Tissue specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).
genes like me logo Genes that share expressions with TFF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TFF1 Gene

Orthologs for TFF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TFF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TFF1 35
  • 99.21 (n)
  • 98.81 (a)
TFF1 36
  • 99 (a)
(Bos Taurus)
Mammalia TFF1 36
  • 58 (a)
(Canis familiaris)
Mammalia TFF1 35
  • 74.9 (n)
  • 67.9 (a)
TFF1 36
  • 65 (a)
(Mus musculus)
Mammalia Tff1 35
  • 71.6 (n)
  • 66.67 (a)
Tff1 16
Tff1 36
  • 61 (a)
(Monodelphis domestica)
Mammalia TFF1 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Tff1 35
  • 69.55 (n)
  • 65.43 (a)
Species with no ortholog for TFF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TFF1 Gene

Gene Tree for TFF1 (if available)
Gene Tree for TFF1 (if available)

Paralogs for TFF1 Gene

Paralogs for TFF1 Gene

Selected SIMAP similar genes for TFF1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFF1: view

Variants for TFF1 Gene

Sequence variations from dbSNP and Humsavar for TFF1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs184432 -- 42,367,453(+) CAGTT(A/G)GTCCC upstream-variant-2KB
rs225356 -- 42,365,959(-) TGCCC(A/G)TCCCA intron-variant
rs225357 -- 42,366,204(+) TCGCA(C/T)TTCTC intron-variant
rs225358 -- 42,366,403(+) AAGCA(C/T)GCCTT intron-variant
rs225359 -- 42,367,327(+) GGAGG(A/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TFF1 Gene

Variant ID Type Subtype PubMed ID
nsv913792 CNV Loss 21882294

Relevant External Links for TFF1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFF1 Gene

Disorders for TFF1 Gene

(2) University of Copenhagen DISEASES for TFF1 Gene

(79) Novoseek inferred disease relationships for TFF1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 81.3 166
breast carcinoma 74.1 49
carcinoma ductal 60 14
metaplasia 60 25
gastric cancer 59 57

Relevant External Links for TFF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TFF1: view

No data available for UniProtKB/Swiss-Prot for TFF1 Gene

Publications for TFF1 Gene

  1. Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. (PMID: 2311759) Takahashi H. … Hayashi K. (FEBS Lett. 1990) 3 4 23
  2. Complete primary structure of the human estrogen-responsive gene (pS2) product. (PMID: 2185238) Mori K. … Hayashi K. (J. Biochem. 1990) 3 4 23
  3. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP- C. (PMID: 15924415) Westley B.R. … May F.E.B. (Biochemistry 2005) 3 4 23
  4. Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. (PMID: 16308573) Chutipongtanate S. … Thongboonkerd V. (J. Clin. Invest. 2005) 3 4 23
  5. Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. (PMID: 16718800) Shi S.-Q. … Yang J.-M. (World J. Gastroenterol. 2006) 3 4 23

Products for TFF1 Gene

Sources for TFF1 Gene

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