Aliases for TFF1 Gene
External Ids for TFF1 Gene
Previous HGNC Symbols for TFF1 Gene
Previous GeneCards Identifiers for TFF1 Gene
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for TFF1 Gene
TFF1 (Trefoil Factor 1) is a Protein Coding gene. Diseases associated with TFF1 include gastrointestinal adenoma and breast cancer. Among its related pathways are Integrated Pancreatic Cancer Pathway and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include growth factor activity. An important paralog of this gene is TFF3.
UniProtKB/Swiss-Prot for TFF1 Gene
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.