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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TFF1 Gene

protein-coding GIFtS: 62
GCID: GC21M043782

trefoil factor 1

(Previous names: breast cancer, estrogen-inducible sequence expressed in...)
(Previous symbol: BCEI)

Explore 72 diseases affiliated with
TFF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Trefoil Factor 1¹ ²		Protein PS2² ³
BCEI¹ ² ³ ⁵		Breast Cancer, Estrogen-Inducible Sequence Expressed In¹
D21S21¹ ²		Trefoil Factor, BCE1, Human PS2 Induced By Estrogen From Human Breast Cancer Cell Line M11
HP1.A¹ ²		Breast Cancer Estrogen-Inducible Sequence²
HPS2¹ ²		Gastrointestinal Trefoil Protein PS2²
PNR-2³		PNR-2³
PS2³		PS2³
Breast Cancer Estrogen-Inducible Protein² ³		HP1.A¹ ²
Polypeptide P1.A² ³

External Ids:	HGNC: 11755¹	Entrez Gene: 7031²	Ensembl: ENSG00000160182⁷	OMIM: 113710⁵	UniProtKB: P04155³

Export aliases for TFF1 gene to outside databases

Previous GC identifers: GC21M040330 GC21M042676 GC21M042655 GC21M029199

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFF1:

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid

domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal

mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and

affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because

of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster

on chromosome 21. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155

Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against

various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

Gene Wiki entry for TFF1 (Trefoil factor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TFF1 gene promoter:
C/EBPbeta STAT1 AML1a Sp1 MyoD NF-kappaB Gfi-1 STAT3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFF1 promoter sequence

Search SABiosciences Chromatin IP Primers for TFF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

TFF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF1 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M043782:	GeneLoc	Nature:405,311-319
Start:	43,782,391 bp from pter	29,329,717 bp from centromere
End:	43,786,703 bp from pter	29,333,970 bp from centromere
Size:	4,313 bases	4,254 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	X00474
genomic clones:	KB169B4

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155 (See protein sequence)

Recommended Name: Trefoil factor 1 precursor

Size: 84 amino acids; 9150 Da

Subunit: Heterodimer with GKN2; disulfide linked

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for TFF1:

1HI7 (3D)

1PS2 (3D)

Explore the universe of human proteins at neXtProt for TFF1: NX_P04155

TFF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003216.1

ENSEMBL proteins:

ENSP00000291527

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for TFF1
	Uscn Proteins for TFF1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

TFF1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TFF1 for domains About GeneDecksing

3 InterPro domains/families:

IPR000519 P_trefoil

IPR017994 P_trefoil_chordata

IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry P04155

ProtoNet protein and cluster: P04155

1 Blocks protein family: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155

Similarity: Contains 1 P-type (trefoil) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155

Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against

various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

Genatlas biochemistry entry for TFF1:

estrogen-inducible protein,expressed in breast cancer,and some digestive tumors (stomach,pancreas,biliary tract)

miRNA Products:		OriGene 3'-UTR Clone: TFF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TFF1:
		hsa-miR-130b*
		SwitchGear 3'UTR luciferase reporter plasmid: TFF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TFF1
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TFF1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008083	growth factor activity	IEA	--

TFF1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TFF1:

Increased number of cells in m

Animal Models:
Mouse knock-out Tff1^tm1Mrio for TFF1
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tff1):

digestive/alimentary

homeostasis/metabolism

tumorigenesis

TFF1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Ligand-independent activation of ESR1 and ESR2

Development_Ligand-independent activation of ESR1 and ESR2

1.00

Development Ligand-independent activation of ESR1 and ESR2

0.97

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

FOXA1 transcription factor network

FOXA1 transcription factor network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TFF1

Development Ligand-independent activation of ESR1 and ESR2

1 GeneGo (Thomson Reuters) Pathway for TFF1

Development Ligand-independent activation of ESR1 and ESR2

3 BioSystems Pathways for TFF1

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	FOXA1 transcription factor network

TFF1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TFF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/28 Interacting proteins for TFF1 (P04155^{1, 2, 3} ENSP00000291527⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN1	Q9UMX0²^,³, ENSP00000365576⁴	MINT-66399 I2D: score=5 STRING: ENSP00000365576
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2863556 I2D: score=3 STRING: ENSP00000357292
PTRF	Q6NZI2³, ENSP00000349541⁴	I2D: score=1 STRING: ENSP00000349541
GKN2	Q86XP6³, ENSP00000329292⁴	I2D: score=1 STRING: ENSP00000329292
MUC6	Q6W4X9³, ENSP00000406861⁴	I2D: score=1 STRING: ENSP00000406861

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	2303034
GO:0006950	response to stress	IEA	--
GO:0007586	digestion	NAS	9043862
GO:0010039	response to iron ion	IEA	--
GO:0030277	maintenance of gastrointestinal epithelium	IEA	--

TFF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TFF1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFF1

1 HMDB Compound for TFF1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/71 Novoseek chemical compound relationships for TFF1 gene (see all 71) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	85.3	409	18543253 (6), 9138084 (4), 11327531 (4), 1627814 (4) (see all 99)
progesterone	79	178	8754494 (4), 9737246 (3), 17883902 (2), 1562465 (2) (see all 99)
4-hydroxytamoxifen	75.9	12	12393183 (2), 9010327 (1), 1826824 (1), 8400321 (1) (see all 8)
tamoxifen	72.7	42	9260605 (4), 8855985 (3), 8611373 (3), 7867021 (3) (see all 20)
estradiol	69.5	49	1319834 (4), 7867021 (4), 16651411 (3), 8915481 (2) (see all 32)
fulvestrant	63.6	2	14531500 (1), 12951045 (1)
letrozole	58.7	2	14559846 (1), 17912634 (1)
allethrin	56.1	2	10064545 (1), 12437293 (1)
arzoxifene	54.5	1	15149724 (1)
genistein	53.1	14	11694625 (3), 10811566 (2), 10376965 (1), 11431339 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about TFF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TFF1 gene:

NM_003225.2

Unigene Cluster for TFF1:

Trefoil factor 1

Hs.162807 [show with all ESTs]

Unigene Representative Sequence: BM923753

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000291527(uc002zax.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TFF1:
		hsa-miR-130b*
		SwitchGear 3'UTR luciferase reporter plasmid: TFF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFF1 (see all 7) OriGene shRNA RFP: TFF1 OriGene siRNA: TFF1
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Additional cDNA sequence:

BC032811.1 M12075.1 X00474.1 X52003.1

6 DOTS entries:

DT.75173682 DT.100060235 DT.121132799 DT.95319988 DT.97864290 DT.75147373

24/190 AceView cDNA sequences (see all 190):

AA524242 BX341674 BM856224 NM_032404 BM675374 AB038160 NM_032405 BM768238

CR590125 CK820254 BM767158 BM855700 BM853888 BM856237 BM850313 NM_003225

AA858276 BM855263 BM854657 AB038157 BF435137 BU535425 BQ083523 BM856488

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TFF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCCTCG

About this image
See TFF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFF1

SOURCE GeneReport for Unigene cluster: Hs.162807

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155

Tissue specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level).

Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous

acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic

ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial

cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet

cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein

level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in

MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous

lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including TFF1:

Growth Factors in human mouse rat

Estrogen Receptor Signaling in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TFF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TFF1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tff1^{1 , 5}	trefoil factor 1^{1, 5}	71.6(n)¹ 66.67(a)¹		17 (15.80 cM)⁵ 21784¹ NM_009362.2¹ NP_033388.1¹ 31161396⁵
chicken (Gallus gallus)	Aves	TFF2⁶	Uncharacterized protein	26(a)	1 ↔ 1	1(112806130-112810005)
lizard (Anolis carolinensis)	Reptilia	TFF2⁶	--	22(a)	1 ↔ 1	3(137788422-137791787)

ENSEMBL Gene Tree for TFF1 (if available)
TreeFam Gene Tree for TFF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TFF1 gene

TFF2² TFF3²

2 SIMAP similar genes for TFF1 using alignment to 1 protein entry: TFF1_HUMAN:

TFF2 TFF3

TFF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141624549^1,2		--	43782016(+)	`TGGGGC/TATCCG`	1	--	ds500¹		0	--	--	--	--
rs146196487^1,2		--	43782067(+)	`TTTCAC/TGCCTG`	1	--	ds500¹		0	--	--	--	--
rs114066387^1,2		--	43782090(+)	`TCTTGG/CACTTG`	1	--	ds500¹		1		WA	118
rs184519614^1,2		--	43782099(+)	`TGCGTC/TCTGCT`	1	--	ds500¹		0	--	--	--	--
rs113157962^1,2	C,	--	43782116(+)	`CCCACC/TGTCCC`	1	--	ds500¹		2		CSA WA	119
rs143932603^1,2		--	43782156(+)	`CCCACC/TGTCCT`	1	--	ds500¹		0	--	--	--	--
rs117481695^1,2	F,	--	43782166(+)	`TACTGT/CACACC`	1	--	ds500¹		1		NA	120
rs148169738^1,2	C,	--	43782177(+)	`CCACC-/GTCCTACTG CACACCCCACTGTCCT`	1	--	ds500¹		0	--	--	--	--
rs72561488^1,2	F,	--	43782430(-)	`TGACTA/GCTCAA`	1	--	ut3¹		6		MN CSA	410
rs72561489^1,2	F,	--	43782526(-)	`TTAGTC/TCCAGA`	1	--	ut3¹		5		MN	408

HapMap Linkage Disequilibrium report for TFF1 (43782391 - 43786703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TFF1: --
Human Gene Mutation Database (HGMD): TFF1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFF1

DNA2.0 Custom Variant and Variant Library Synthesis for TFF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TFF1 for disorders           About GeneDecksing

OMIM gene information: 113710    OMIM disorders: --

20/72 diseases for TFF1 (see all 72):    About MalaCards

breast cancer estrogen-receptor negative breast cancer multiple endocrine neoplasia type 2a autosomal recessive nonsyndromic deafness

hermansky-pudlak syndrome multiple endocrine neoplasia bile reflux nonsyndromic deafness

non-small cell lung carcinoma barrett's esophagus inflammatory bowel disease duodenal ulcer

carcinoma cystadenocarcinoma peptic ulcer gastritis

fibromatosis estrogen resistance gallbladder carcinoma benign tumors

2 diseases from the University of Copenhagen DISEASES database for TFF1:

Breast cancer Carcinoma

10/79 Novoseek disease relationships for TFF1 gene (see all 79) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	81.3	221	11919164 (6), 9260605 (4), 16267614 (4), 8161252 (4) (see all 99)
breast carcinoma	74.1	54	8110971 (3), 10080679 (3), 1352440 (2), 7720888 (2) (see all 39)
carcinoma ductal	60	15	11709137 (2), 8385977 (2), 15375487 (2), 8253523 (1) (see all 11)
metaplasia	60	33	10190312 (4), 7557569 (3), 9600121 (3), 8818606 (2) (see all 16)
gastric cancer	59	88	12324709 (6), 16697734 (5), 15059374 (4), 16718800 (4) (see all 27)
tumors	56.4	284	2354435 (7), 7667210 (6), 14756547 (6), 9587935 (5) (see all 99)
gastric carcinoma	56.3	54	8911122 (6), 14601088 (5), 12379766 (5), 17143957 (4) (see all 14)
carcinoma	52.9	110	19589871 (6), 9221798 (4), 8818606 (3), 11327531 (3) (see all 44)
ductal breast carcinoma	52.5	3	11523925 (1), 9202892 (1), 11060273 (1)
intestinal carcinoma	51.3	4	8911122 (1), 12210076 (1)

Human Genome Epidemiology (HuGE) Navigator: TFF1 (8 documents)

Export disorders for TFF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TFF1 gene, integrated from 9 sources (see all 610):
(articles sorted by number of sources associating them with TFF1)

Utopia: connect your pdf to the dynamic
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Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues. (PubMed id 17143957)^{1, 2, 9} Ren J.L.... Shi H.-X. (2006)
Complete primary structure of the human estrogen-responsive gene (pS2) product. (PubMed id 2185238)^{1, 2, 9} Mori K.... Hayashi K. (1990)
Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. (PubMed id 2311759)^{1, 2, 9} Takahashi H....Hayashi K. (1990)
Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. (PubMed id 16718800)^{1, 2, 9} Shi S.-Q.... Yang J.-M. (2006)
Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP- C. (PubMed id 15924415)^{1, 2, 9} Westley B.R.... May F.E.B. (2005)
Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. (PubMed id 16308573)^{1, 2, 9} Chutipongtanate S....Thongboonkerd V. (2005)
Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)^{1, 3, 9} Gott P....Blin N. (1996)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7031	HGNC: 11755	AceView: TFF1andTMPRSS3	Ensembl:ENSG00000160182	euGenes: HUgn7031
ECgene: TFF1	H-InvDB: TFF1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TFF1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFF1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TFF1 gene
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Patent Information for TFF1 gene:
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trefoil factor 1

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