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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFF1 Gene

protein-coding   GIFtS: 69
GCID: GC21M043782

Trefoil Factor 1

(Previous names: breast cancer, estrogen-inducible sequence expressed in)
(Previous symbol: BCEI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Trefoil Factor 11 2     HPS22
BCEI1 2 3 5     Breast Cancer Estrogen-Inducible Sequence2
Breast Cancer Estrogen-Inducible Protein2 3     Gastrointestinal Trefoil Protein PS22
Polypeptide P1.A2 3     pNR-22
Protein PS22 3     pS22
Breast Cancer, Estrogen-Inducible Sequence Expressed In1     PNR-23
Trefoil Factor, BCE1, Human PS2 Induced By Estrogen From Human Breast
Cancer Cell Line M11
     PS23
D21S212     hP1.A3
HP1.A2     

External Ids:    HGNC: 117551   Entrez Gene: 70312   Ensembl: ENSG000001601827   OMIM: 1137105   UniProtKB: P041553   

Export aliases for TFF1 gene to outside databases

Previous GC identifers: GC21M040330 GC21M042676 GC21M042655 GC21M029199


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFF1 Gene:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid
domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal
mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer,
and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied
because of its expression in human tumors. This gene and two other related trefoil family member genes are found
in a cluster on chromosome 21. (provided by RefSeq, Jul 2008)

GeneCards Summary for TFF1 Gene: 
TFF1 (trefoil factor 1) is a protein-coding gene. Diseases associated with TFF1 include bile reflux, and inflammatory breast carcinoma, and among its related super-pathways are Transcription CREB pathway. GO annotations related to this gene include protein binding and growth factor activity. An important paralog of this gene is TFF2.

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier
against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

Gene Wiki entry for TFF1 (Trefoil factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFF1 gene promoter:
         C/EBPbeta   STAT1   AML1a   Sp1   MyoD   NF-kappaB   Gfi-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFF1 promoter sequence

   Search SABiosciences Chromatin IP Primers for TFF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TFF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M043782:   GeneLoc Nature:405,311-319
Start:
43,782,391 bp from pter       29,329,717 bp from centromere
End:
43,786,703 bp from pter 29,333,970 bp from centromere
Size:
4,313 bases 4,254 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: X00474
genomic clones: KB169B4


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155 (See protein sequence)
Recommended Name: Trefoil factor 1 precursor  
Size: 84 amino acids; 9150 Da
Subunit: Heterodimer with GKN2; disulfide linked
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for TFF1:
1HI7 (3D)        1PS2 (3D)    

Explore the universe of human proteins at neXtProt for TFF1: NX_P04155

Explore proteomics data for TFF1 at MOPED 

TFF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TFF1 Protein Expression

REFSEQ proteins: NP_003216.1  
ENSEMBL proteins: 
 ENSP00000291527  

Human Recombinant Protein Products for TFF1: 
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GenScript Purified and Recombinant Proteins for TFF1
Novus Biologicals TFF1 Proteins
Novus Biologicals TFF1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for TFF1
Cloud-Clone Corp. Proteins for TFF1 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

TFF1 for ontologies           About GeneDecksing



TFF1 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for TFF1 

Assay Products for TFF1: 
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Cloud-Clone Corp. ELISAs for TFF1 
Cloud-Clone Corp. CLIAs for TFF1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR000519 P_trefoil
 IPR017994 P_trefoil_chordata
 IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry P04155

ProtoNet protein and cluster: P04155

1 Blocks protein domain: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Similarity: Contains 1 P-type (trefoil) domain


TFF1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFF1_HUMAN, P04155
Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier
against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

     Genatlas biochemistry entry for TFF1:
estrogen-inducible protein,expressed in breast cancer,and some digestive tumors (stomach,pancreas,biliary tract)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0008083growth factor activity IEA--
     
TFF1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TFF1:
 Increased number of cells in m 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tff1):
 digestive/alimentary  homeostasis/metabolism  tumorigenesis 

TFF1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tff1tm1Mrio for TFF1

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TFF1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFF1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFF1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFF1 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF1
1 QIAGEN miScript miRNA Assays for microRNA that regulate TFF1:
hsa-miR-130b*
SwitchGear 3'UTR luciferase reporter plasmidTFF1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of TFF1

Clone
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OriGene clones in human, mouse for TFF1 (see all 7)
OriGene ORF clones in mouse, rat for TFF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TFF1 (NM_003225)
Sino Biological Human cDNA Clone for TFF1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF1
Sirion Biotech Customized lentivirus for stable overexpression of TFF1 
                     Customized lentivirus expression plasmids for stable overexpression of TFF1 

Cell Line
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Search LifeMap BioReagents cell lines for TFF1
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TFF1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Development Ligand-independent activation of ESR1 and ESR2
Development Ligand-independent activation of ESR1 and ESR20.34
2FOXA1 transcription factor network
FOXA1 transcription factor network
3Adhesion
Adhesion
4Integrated Pancreatic Cancer Pathway
Integrated Pancreatic Cancer Pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TFF1
    Development Ligand-independent activation of ESR1 and ESR2


1 Cell Signaling Technology (CST) Pathway for TFF1
    Adhesion

1 GeneGo (Thomson Reuters) Pathway for TFF1
    Development Ligand-independent activation of ESR1 and ESR2

2 BioSystems Pathways for TFF1
    Integrated Pancreatic Cancer Pathway
FOXA1 transcription factor network




TFF1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/28 Interacting proteins for TFF1 (P041551, 2, 3 ENSP000002915274) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
UBQLN1Q9UMX02, 3, ENSP000003655764MINT-66399 I2D: score=5 STRING: ENSP00000365576
UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863556 I2D: score=3 STRING: ENSP00000357292
PTRFQ6NZI23, ENSP000003495414I2D: score=1 STRING: ENSP00000349541
GKN2Q86XP63, ENSP000003292924I2D: score=1 STRING: ENSP00000329292
MUC6Q6W4X93, ENSP000004068614I2D: score=1 STRING: ENSP00000406861
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process TAS2303034
GO:0006950response to stress IEA--
GO:0007586digestion NAS9043862
GO:0008285negative regulation of cell proliferation IEA--
GO:0010039response to iron ion IEA--

TFF1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TFF1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFF1

1 HMDB Compound for TFF1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

10/71 Novoseek inferred chemical compound relationships for TFF1 gene (see all 71)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 85.3 409 18543253 (6), 9138084 (4), 11327531 (4), 1627814 (4) (see all 99)
progesterone 79 178 8754494 (4), 9737246 (3), 17883902 (2), 1562465 (2) (see all 99)
4-hydroxytamoxifen 75.9 12 12393183 (2), 9010327 (1), 1826824 (1), 8400321 (1) (see all 8)
tamoxifen 72.7 42 9260605 (4), 8855985 (3), 8611373 (3), 7867021 (3) (see all 20)
estradiol 69.5 49 1319834 (4), 7867021 (4), 16651411 (3), 8915481 (2) (see all 32)
fulvestrant 63.6 2 14531500 (1), 12951045 (1)
letrozole 58.7 2 14559846 (1), 17912634 (1)
allethrin 56.1 2 10064545 (1), 12437293 (1)
arzoxifene 54.5 1 15149724 (1)
genistein 53.1 14 11694625 (3), 10811566 (2), 10376965 (1), 11431339 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about TFF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TFF1 gene: 
NM_003225.2  

Unigene Cluster for TFF1:

Trefoil factor 1
Hs.162807  [show with all ESTs]
Unigene Representative Sequence: BM923753
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000291527(uc002zax.1)
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFF1
1 QIAGEN miScript miRNA Assays for microRNA that regulate TFF1:
hsa-miR-130b*
SwitchGear 3'UTR luciferase reporter plasmidTFF1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TFF1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFF1
Clone
Products:
     
OriGene clones in human, mouse for TFF1 (see all 7)
OriGene ORF clones in mouse, rat for TFF1
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GenScript: all cDNA clones in your preferred vector: TFF1 (NM_003225)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF1
Sirion Biotech Customized lentivirus for stable overexpression of TFF1 
                     Customized lentivirus expression plasmids for stable overexpression of TFF1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TFF1
OriGene qSTAR qPCR primer pairs in human, mouse for TFF1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFF1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF1

Additional mRNA sequence: 

BC032811.1 M12075.1 X00474.1 X52003.1 

6 DOTS entries:

DT.75173682  DT.100060235  DT.121132799  DT.95319988  DT.97864290  DT.75147373 

24/190 AceView cDNA sequences (see all 190):

BM853888 BM856237 X52003 BX341674 BM856224 BM767158 AA858276 BM853943 
BM142503 CK820253 BQ083523 NM_003225 AB038160 BM817954 BF435670 AK172842 
AB038157 CR590125 AI925552 BM854657 BM855339 BM675374 BM768282 AI469095 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TFF1 expression in normal human tissues (normalized intensities)      TFF1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGGCCCTCG
TFF1 Expression
About this image


TFF1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
         stomach, upper ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
         rectum ; glandular cells   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         small intestine ; glandular cells   
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Uterus (Reproductive System)
         cervix, uterine ; glandular cells   

See TFF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFF1

SOURCE GeneReport for Unigene cluster: Hs.162807

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Tissue specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level).
Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus,
mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine
pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in
the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in
the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level).
Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary
tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the
regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in
gastric cancer (at protein level)

    SABiosciences Expression via Pathway-Focused PCR Arrays including TFF1: 
          Growth Factors in human mouse rat
          Estrogen Receptor Signaling in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TFF1
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFF1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFF1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TFF1 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tff11 , 5 trefoil factor 11, 5 71.6(n)1
66.67(a)1
  17 (15.80 cM)5
217841  NM_009362.21  NP_033388.11 
 311613965 
chicken
(Gallus gallus)
Aves TFF26
Uncharacterized protein
20(a)
1 ↔ 1
1(108710820-108714731)
lizard
(Anolis carolinensis)
Reptilia TFF26
Uncharacterized protein
16(a)
1 ↔ 1
3(137788422-137791787)


ENSEMBL Gene Tree for TFF1 (if available)
TreeFam Gene Tree for TFF1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TFF1 gene
TFF22  TFF32  
2 SIMAP similar genes for TFF1 using alignment to 1 protein entry:     TFF1_HUMAN:
TFF2    TFF3

TFF1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/230 SNPs in TFF1 are shown (see all 230)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0152824
A gastric carcinoma sample4--see VAR_0152822 T K mis40--------
VAR_0152864
A gastric carcinoma sample4--see VAR_0152862 G V mis40--------
VAR_0152814
A gastric carcinoma sample4--see VAR_0152812 T I mis40--------
VAR_0152844
A gastric carcinoma sample4--see VAR_0152842 E K mis40--------
VAR_0152834
A gastric carcinoma sample4--see VAR_0152832 A D mis40--------
VAR_0152854
----see VAR_0152852 V I mis40--------
rs1416245491,2
--43782016(+) TGGGGC/TATCCG 1 -- ds50010--------
rs1461964871,2
--43782067(+) TTTCAC/TGCCTG 1 -- ds50010--------
rs1140663871,2
F--43782090(+) TCTTGG/CACTTG 1 -- ds50011Minor allele frequency- C:0.01WA 118
rs1845196141,2
--43782099(+) TGCGTC/TCTGCT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TFF1 (43782391 - 43786703 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TFF1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv913792CNV Loss21882294


Human Gene Mutation Database (HGMD): TFF1
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TFF1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 113710    OMIM disorders: --

20/60 diseases for TFF1 (see all 60):    About MalaCards
bile reflux    inflammatory breast carcinoma    ductal carcinoma in situ    estrogen-receptor negative breast cancer
multiple endocrine neoplasia type 2a    breast disease    gastric ulcer    benign tumors
barrett's esophagus    duodenal ulcer    adenosquamous carcinoma    autosomal recessive nonsyndromic deafness
breast cancer    endocervicitis    gastritis    cholecystitis
duodenitis    pterygium    nonsyndromic deafness    fibromatosis

2 diseases from the University of Copenhagen DISEASES database for TFF1:
Breast cancer     Carcinoma

TFF1 for disorders           About GeneDecksing

10/79 Novoseek inferred disease relationships for TFF1 gene (see all 79)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 81.3 221 11919164 (6), 9260605 (4), 16267614 (4), 8161252 (4) (see all 99)
breast carcinoma 74.1 54 8110971 (3), 10080679 (3), 1352440 (2), 7720888 (2) (see all 39)
carcinoma ductal 60 15 11709137 (2), 8385977 (2), 15375487 (2), 8253523 (1) (see all 11)
metaplasia 60 33 10190312 (4), 7557569 (3), 9600121 (3), 8818606 (2) (see all 16)
gastric cancer 59 88 12324709 (6), 16697734 (5), 15059374 (4), 16718800 (4) (see all 27)
tumors 56.4 284 2354435 (7), 7667210 (6), 14756547 (6), 9587935 (5) (see all 99)
gastric carcinoma 56.3 54 8911122 (6), 14601088 (5), 12379766 (5), 17143957 (4) (see all 14)
carcinoma 52.9 110 19589871 (6), 9221798 (4), 8818606 (3), 11327531 (3) (see all 44)
ductal breast carcinoma 52.5 3 11523925 (1), 9202892 (1), 11060273 (1)
intestinal carcinoma 51.3 4 8911122 (1), 12210076 (1)

Genetic Association Database (GAD): TFF1
Human Genome Epidemiology (HuGE) Navigator: TFF1 (8 documents)

Export disorders for TFF1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TFF1 gene, integrated from 9 sources (see all 616):
(articles sorted by number of sources associating them with TFF1)
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world of online information

  1. Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues. (PubMed id 17143957)1, 2, 9 Ren J.L.... Shi H.-X. (2006)
  2. Complete primary structure of the human estrogen-responsive gene (pS2) product. (PubMed id 2185238)1, 2, 9 Mori K.... Hayashi K. (1990)
  3. Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. (PubMed id 2311759)1, 2, 9 Takahashi H....Hayashi K. (1990)
  4. Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. (PubMed id 16718800)1, 2, 9 Shi S.-Q.... Yang J.-M. (2006)
  5. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP- C. (PubMed id 15924415)1, 2, 9 Westley B.R.... May F.E.B. (2005)
  6. Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. (PubMed id 16308573)1, 2, 9 Chutipongtanate S....Thongboonkerd V. (2005)
  7. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)1, 3, 9 Gott P....Blin N. (1996)
  8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  9. Prothrombin Haplotype Associated With Kidney Stone Di sease in Northeastern Thai Patients. (PubMed id 21067798)1, 4 Rungroj N....Yenchitsomanus P.T. (2010)
  10. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7031 HGNC: 11755 AceView: TFF1andTMPRSS3 Ensembl:ENSG00000160182 euGenes: HUgn7031
ECgene: TFF1 H-InvDB: TFF1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TFF1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFF1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TFF1 gene:
Search GeneIP for patents involving TFF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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