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TFF1 Gene

protein-coding   GIFtS: 69
GCID: GC21M043782

Trefoil Factor 1

(Previous names: breast cancer, estrogen-inducible sequence expressed in)
(Previous symbol: BCEI)
  See TFF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Trefoil Factor 11 2     HPS22
BCEI1 2 3 5     Breast Cancer Estrogen-Inducible Sequence2
Breast Cancer Estrogen-Inducible Protein2 3     Gastrointestinal Trefoil Protein PS22
Polypeptide P1.A2 3     pNR-22
Protein PS22 3     pS22
Breast Cancer, Estrogen-Inducible Sequence Expressed In1     PNR-23
Trefoil Factor, BCE1, Human PS2 Induced By Estrogen From Human Breast
Cancer Cell Line M11
     PS23
D21S212     hP1.A3
HP1.A2     

External Ids:    HGNC: 117551   Entrez Gene: 70312   Ensembl: ENSG000001601827   OMIM: 1137105   UniProtKB: P041553   
ORGUL members:         

Export aliases for TFF1 gene to outside databases

Previous GC identifers: GC21M040330 GC21M042676 GC21M042655 GC21M029199


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFF1 Gene:
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid
domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal
mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer,
and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied
because of its expression in human tumors. This gene and two other related trefoil family member genes are found
in a cluster on chromosome 21. (provided by RefSeq, Jul 2008)

GeneCards Summary for TFF1 Gene:
TFF1 (trefoil factor 1) is a protein-coding gene. Diseases associated with TFF1 include bile reflux, and multiple endocrine neoplasia type 2a. GO annotations related to this gene include growth factor activity. An important paralog of this gene is TFF2.

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier
against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

Gene Wiki entry for TFF1 (Trefoil factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFF1 gene promoter:
         C/EBPbeta   STAT1   AML1a   Sp1   MyoD   NF-kappaB   Gfi-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TFF1 promoter sequence

   Search Chromatin IP Primers for TFF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TFF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFF1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M043782:   GeneLoc Nature:405,311-319
Start:
43,782,391 bp from pter       29,329,717 bp from centromere
End:
43,786,703 bp from pter 29,333,970 bp from centromere
Size:
4,313 bases 4,254 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: X00474
genomic clones: KB169B4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155 (See protein sequence)
Recommended Name: Trefoil factor 1 precursor  
Size: 84 amino acids; 9150 Da
Subunit: Heterodimer with GKN2; disulfide linked
2 PDB 3D structures from and Proteopedia for TFF1:
1HI7 (3D)        1PS2 (3D)    

Explore the universe of human proteins at neXtProt for TFF1: NX_P04155

Explore proteomics data for TFF1 at MOPED


See TFF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003216.1  
ENSEMBL proteins: 
 ENSP00000291527  

TFF1 Human Recombinant Protein Products:

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antibodies-online proteins for TFF1 (40 products) 

 
antibodies-online peptides for TFF1

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antibodies-online antibodies for TFF1 (63 products) 

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antibodies-online kits for TFF1 (30 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR000519 P_trefoil
 IPR028824 TFF1
 IPR017994 P_trefoil_chordata
 IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry P04155

ProtoNet protein and cluster: P04155

1 Blocks protein domain: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Similarity: Contains 1 P-type (trefoil) domain


Find genes that share domains with TFF1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TFF1_HUMAN, P04155
Function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier
against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine

     Genatlas biochemistry entry for TFF1:
estrogen-inducible protein,expressed in breast cancer,and some digestive tumors (stomach,pancreas,biliary tract)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0008083growth factor activity IEA--
     
Find genes that share ontologies with TFF1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for TFF1:
 Increased number of cells in m 

     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tff1):
 digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  integument  tumorigenesis 

Find genes that share phenotypes with TFF1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Tff1tm1Mrio for TFF1

   genOway: Develop your customized and physiologically relevant rodent model for TFF1

miRNA
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1 qRT-PCR Assays for microRNA that regulate TFF1:
hsa-miR-130b*
SwitchGear 3'UTR luciferase reporter plasmidTFF1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TFF1
Predesigned siRNA for gene silencing in human, mouse, rat TFF1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for TFF1

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OriGene clones in human, mouse for TFF1 (see all 6)
OriGene ORF clones in mouse, rat for TFF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TFF1 (NM_003225)
Sino Biological Human cDNA Clone for TFF1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFF1

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for TFF1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF1

Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-10016) for TFF1 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TFF1_HUMAN, P04155: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

Find genes that share ontologies with TFF1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TFF1 About    
See pathways by source

SuperPathContained pathways About
1Transcription CREB pathway
Development Ligand independent activation of ESR1 and ESR20.34
2Integrated Pancreatic Cancer Pathway
Integrated Pancreatic Cancer Pathway
3FOXA1 transcription factor network
FOXA1 transcription factor network
4Adhesion
Adhesion


Find genes that share SuperPaths with TFF1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Cell Signaling Technology (CST) Pathway for TFF1
    Adhesion

1 GeneGo (Thomson Reuters) Pathway for TFF1
    Development Ligand-independent activation of ESR1 and ESR2

2 BioSystems Pathways for TFF1
    Integrated Pancreatic Cancer Pathway
FOXA1 transcription factor network



    Pathway & Disease-focused RT2 Profiler PCR Arrays including TFF1: 
          Growth Factors in human mouse rat
          Estrogen Receptor Signaling in human mouse rat

Interactions:

    GeneGlobe Interaction Network for TFF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TFF1 (P041551, 2, 3 ENSP000002915274) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
UBQLN1Q9UMX02, 3, ENSP000003655764MINT-66399 I2D: score=5 STRING: ENSP00000365576
UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863556 I2D: score=3 STRING: ENSP00000357292
PTRFQ6NZI23, ENSP000003495414I2D: score=1 STRING: ENSP00000349541
GKN2Q86XP63, ENSP000003292924I2D: score=1 STRING: ENSP00000329292
MUC6Q6W4X93, ENSP000004068614I2D: score=1 STRING: ENSP00000406861
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process TAS2303034
GO:0006950response to stress ----
GO:0007586digestion NAS9043862
GO:0008285negative regulation of cell proliferation IEA--
GO:0010039response to iron ion IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TFF1

1 HMDB Compound for TFF1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Selected Novoseek inferred chemical compound relationships for TFF1 gene (see all 71)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 85.3 409 18543253 (6), 9138084 (4), 11327531 (4), 1627814 (4) (see all 99)
progesterone 79 178 8754494 (4), 9737246 (3), 17883902 (2), 1562465 (2) (see all 99)
4-hydroxytamoxifen 75.9 12 12393183 (2), 9010327 (1), 1826824 (1), 8400321 (1) (see all 8)
tamoxifen 72.7 42 9260605 (4), 8855985 (3), 8611373 (3), 7867021 (3) (see all 20)
estradiol 69.5 49 1319834 (4), 7867021 (4), 16651411 (3), 8915481 (2) (see all 32)
fulvestrant 63.6 2 14531500 (1), 12951045 (1)
letrozole 58.7 2 14559846 (1), 17912634 (1)
allethrin 56.1 2 10064545 (1), 12437293 (1)
arzoxifene 54.5 1 15149724 (1)
genistein 53.1 14 11694625 (3), 10811566 (2), 10376965 (1), 11431339 (1) (see all 10)



Find genes that share compounds with TFF1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TFF1 gene: 
NM_003225.2  

Unigene Cluster for TFF1:

Trefoil factor 1
Hs.162807  [show with all ESTs]
Unigene Representative Sequence: BM923753
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000291527(uc002zax.1)
miRNA
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1 qRT-PCR Assays for microRNA that regulate TFF1:
hsa-miR-130b*
SwitchGear 3'UTR luciferase reporter plasmidTFF1 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat TFF1
Clone
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GenScript: all cDNA clones in your preferred vector: TFF1 (NM_003225)
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Primer
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OriGene qPCR primer pairs and template standards for TFF1
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  QuantiTect SYBR Green Assays in human, mouse, rat TFF1
  QuantiFast Probe-based Assays in human, mouse, rat TFF1
Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-10016) for TFF1 

Additional mRNA sequence: 

BC032811.1 M12075.1 X00474.1 X52003.1 

6 DOTS entries:

DT.75173682  DT.100060235  DT.121132799  DT.95319988  DT.97864290  DT.75147373 

Selected AceView cDNA sequences (see all 190):

BM768282 BU535425 BM768507 BM798962 NM_003225 BM798931 AI970839 BM853888 
BM850313 AI925552 BM856224 BF435670 AI469095 AA307578 BM855263 NM_024022 
BM855692 BF435137 CR590125 BM817954 CK820253 BM855339 AA524242 BX341674 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TFF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGGCCCTCG
TFF1 Expression
About this image

TFF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TFF1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.162807

UniProtKB/Swiss-Prot: TFF1_HUMAN, P04155
Tissue specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level).
Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus,
mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine
pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in
the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in
the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level).
Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary
tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the
regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in
gastric cancer (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including TFF1: 
          Growth Factors in human mouse rat
          Estrogen Receptor Signaling in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TFF1
OriGene qSTAR qPCR primer pairs in human, mouse for TFF1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFF1
QuantiTect SYBR Green Assays in human, mouse, rat TFF1
QuantiFast Probe-based Assays in human, mouse, rat TFF1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFF1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TFF1 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tff11 , 5 trefoil factor 11, 5 71.6(n)1
66.67(a)1
  17 (15.80 cM)5
217841  NM_009362.21  NP_033388.11 
 311613965 


ENSEMBL Gene Tree for TFF1 (if available)
TreeFam Gene Tree for TFF1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TFF1 gene
TFF22  TFF32  
2 SIMAP similar genes for TFF1 using alignment to 1 protein entry:     TFF1_HUMAN:
TFF2    TFF3

Find genes that share paralogs with TFF1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TFF1 (see all 230)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0152824
A gastric carcinoma sample4--see VAR_0152822 T K mis40--------
VAR_0152864
A gastric carcinoma sample4--see VAR_0152862 G V mis40--------
VAR_0152814
A gastric carcinoma sample4--see VAR_0152812 T I mis40--------
VAR_0152844
A gastric carcinoma sample4--see VAR_0152842 E K mis40--------
VAR_0152834
A gastric carcinoma sample4--see VAR_0152832 A D mis40--------
rs1416245491,2
--43782016(+) TGGGGC/TATCCG 1 -- ds50010--------
rs1461964871,2
--43782067(+) TTTCAC/TGCCTG 1 -- ds50010--------
rs1140663871,2
F--43782090(+) TCTTGG/CACTTG 1 -- ds50011Minor allele frequency- C:0.01WA 118
rs1845196141,2
--43782099(+) TGCGTC/TCTGCT 1 -- ds50010--------
rs1131579621,2
C,F--43782116(+) CCCACC/TGTCCC 1 -- ds50012Minor allele frequency- T:0.05CSA WA 119

HapMap Linkage Disequilibrium report for TFF1 (43782391 - 43786703 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TFF1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv913792CNV Loss21882294

Human Gene Mutation Database (HGMD): TFF1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TFF1
DNA2.0 Custom Variant and Variant Library Synthesis for TFF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 113710    OMIM disorders: --

9 diseases for TFF1:    
About MalaCards
bile reflux    multiple endocrine neoplasia type 2a    inflammatory breast carcinoma    ductal carcinoma in situ
gastric ulcer    autosomal recessive nonsyndromic deafness    gastritis    breast cancer
pancreatic cancer

2 diseases from the University of Copenhagen DISEASES database for TFF1:
Breast cancer     Carcinoma

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Selected Novoseek inferred disease relationships for TFF1 gene (see all 79)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 81.3 221 11919164 (6), 9260605 (4), 16267614 (4), 8161252 (4) (see all 99)
breast carcinoma 74.1 54 8110971 (3), 10080679 (3), 1352440 (2), 7720888 (2) (see all 39)
carcinoma ductal 60 15 11709137 (2), 8385977 (2), 15375487 (2), 8253523 (1) (see all 11)
metaplasia 60 33 10190312 (4), 7557569 (3), 9600121 (3), 8818606 (2) (see all 16)
gastric cancer 59 88 12324709 (6), 16697734 (5), 15059374 (4), 16718800 (4) (see all 27)
tumors 56.4 284 2354435 (7), 7667210 (6), 14756547 (6), 9587935 (5) (see all 99)
gastric carcinoma 56.3 54 8911122 (6), 14601088 (5), 12379766 (5), 17143957 (4) (see all 14)
carcinoma 52.9 110 19589871 (6), 9221798 (4), 8818606 (3), 11327531 (3) (see all 44)
ductal breast carcinoma 52.5 3 11523925 (1), 9202892 (1), 11060273 (1)
intestinal carcinoma 51.3 4 8911122 (1), 12210076 (1)

Genetic Association Database (GAD): TFF1
Human Genome Epidemiology (HuGE) Navigator: TFF1 (8 documents)

Export disorders for TFF1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TFF1 gene, integrated from 10 sources (see all 619):
(articles sorted by number of sources associating them with TFF1)
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  1. Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues. (PubMed id 17143957)1, 2, 9 Ren J.L.... Shi H.-X. (World J. Gastroenterol. 2006)
  2. Complete primary structure of the human estrogen-responsive gene (pS2) product. (PubMed id 2185238)1, 2, 9 Mori K.... Hayashi K. (J. Biochem. 1990)
  3. Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. (PubMed id 2311759)1, 2, 9 Takahashi H....Hayashi K. (FEBS Lett. 1990)
  4. Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. (PubMed id 16718800)1, 2, 9 Shi S.-Q.... Yang J.-M. (World J. Gastroenterol. 2006)
  5. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP- C. (PubMed id 15924415)1, 2, 9 Westley B.R.... May F.E.B. (Biochemistry 2005)
  6. Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. (PubMed id 16308573)1, 2, 9 Chutipongtanate S....Thongboonkerd V. (J. Clin. Invest. 2005)
  7. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. (PubMed id 9043862)1, 3, 9 GAPtt P....Blin N. (Eur. J. Hum. Genet. 1996)
  8. Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients. (PubMed id 21067798)1, 4 Rungroj N....Yenchitsomanus P.T. (Urology 2011)
  9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
  10. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7031 HGNC: 11755 AceView: TFF1andTMPRSS3 Ensembl:ENSG00000160182 euGenes: HUgn7031
ECgene: TFF1 H-InvDB: TFF1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TFF1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFF1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TFF1 gene:
Search GeneIP for patents involving TFF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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