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TFE3 Gene

protein-coding GIFtS: 62

GC0XM048771

transcription factor binding to IGHM enhancer 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
OTTHUMP00000024272 ^²
RCCP2 ^²
TFEA ^¹, ²
bHLHe33 ^¹, ²

Descriptions
Renal cell carcinoma, papillary ^²
Transcription factor for IgH enhancer ^²
transcription factor E family, member A ^²
transcription factor E3 ^²
transcription factor binding to IGHM enhancer 3 ^²

External Ids
HGNC: 11752¹
Entrez Gene: 7030²
UniProtKB: P19532³
Ensembl: ENSG00000068323⁷

Search outside databases for aliases for TFE3 gene

Previous GC identifers: GC0XM047669 GC0XM047127 GC0XM047912 GC0XM048642

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TFE3:

TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of

the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991

[PubMed 1685140]).[supplied by OMIM]

UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532

Function: Positive-acting transcription factor that binds to the immunoglobulin enchancer MUE3

motif. It also binds very well to a USF/MLTF site. Binding of TFE3 to DNA induces DNA binding

Gene Wiki entry for TFE3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TFE3 gene

Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.22

TFE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM048771: (about GC identifiers)

Start:	48,771,186 bp from pter
End:	48,787,934 bp from pter
Size:	16,749 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532 (See protein sequence)

Recommended Name: Transcription factor E3

Size: 575 amino acids; 61521 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein

Subcellular location: Nucleus

Sequence caution: Sequence=CAA35714.1; Type=Frameshift; Positions=557; Sequence=CAA65800.1;

Type=Erroneous gene model prediction;

Secondary accessions: A8MZL6 Q92757 Q92758 Q99964

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006512.2

ENSEMBL proteins:

ENSP00000338360 ENSP00000314129

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TFE3)
	Human Recombinant Proteins from Abnova (TFE3)

OriGene Purified Recombinant Human Protein: TFE3

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for TFE3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TFE3
	Sigma-Aldrich Antibodies for TFE3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TFE3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TFE3)
	Novus Biologicals Antibodies for TFE3

Assays for TFE3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P19532

ProtoNet protein and cluster: P19532

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532

Similarity: Belongs to the MiT/TFE family

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006521

Applied Biosystems Silencer® siRNAs for TFE3

Sigma-Aldrich siRNA for TFE3

Sigma-Aldrich shRNA for TFE3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TFE3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006521
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006521
untagged cDNA clones in CMV expression vector (see all 2): NM_006521

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006521

UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532

Function: Positive-acting transcription factor that binds to the immunoglobulin enchancer MUE3

motif. It also binds very well to a USF/MLTF site. Binding of TFE3 to DNA induces DNA binding

Genatlas biochemistry entry for TFE3:

transcription factor,binding IGH enhancer motif muE3 (see also RCCPX)

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tcfe3):

craniofacial	growth/size	lethality-postnatal	normal	pigmentation
skeleton	skin/coat/nails	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	1685140
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TFE3 (Your Favorite Gene powered by Ingenuity)

TGF-&beta

GeneDecks TFE3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TFE3

5/36 Interacting proteins for TFE3 (P19532¹ ENSP00000338360³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACLY	P53396¹	EBI-1048957, EBI-1042794
AKR1B1	P15121¹	EBI-1048957, EBI-1052491
CLTC	Q00610¹	EBI-1048957, EBI-354967
CUL2	Q13617¹	EBI-1048957, EBI-456179
EIF3A	Q14152¹	EBI-1048957, EBI-366617

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045670	regulation of osteoclast differentiation	IEA	--
GO:0045893	positive regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TFE3
3 Novoseek chemical compound relationships for TFE3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	59.20	9	2044953 (2), 11467950 (1), 9699482 (1), 12719541 (1) (see all 8)
proline	5.51	1	7479029 (1)
glucose	0.00	2	9699482 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TFE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TFE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006521

Sigma-Aldrich siRNA for TFE3

Sigma-Aldrich shRNA for TFE3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006521

REFSEQ mRNAs for TFE3 gene:

NM_006521.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006521

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006521
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006521
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006521

Additional cDNA sequence:

AK055522.1 AK295497.1 AK310095.1 AK313540.1 AY034077.1 AY034078.1 AY927577.1 BC001532.2

BC026027.1 CR618971.1 X51330.1 X96717.1

19 DOTS entries:

DT.97844778 DT.316351 DT.100054917 DT.97782045 DT.92435228 DT.91990780 DT.100773318 DT.95241255

DT.91912712 DT.99987720 DT.91807827 DT.92435223 DT.121313899 DT.121313972 DT.91751874 DT.91976715

DT.92435220 DT.97767457 DT.92435221

24/193 AceView cDNA sequences (see all 193 ):

BI906752 BM476345 BQ679200 AL161985 AI366901 CR618971 BC026027 BQ951491

BE396479 BX098888 AI049882 AI620369 BX380994 BE904541 BU632914 AI659215

CO249977 R30674 AL040493 BQ029594 AU124359 BQ949183 BE819496 BC001532

highest scoring ESTs for TFE3:

X96717 AL538216 BC026027 BE304385 BE387336 BF984983 BG333988 BM904206 BQ228525 BQ881401

Unigene Cluster for TFE3:

Transcription factor binding to IGHM enhancer 3

Hs.274184 [show with all ESTs]

Unigene Representative Sequence: NM_006521

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TFE3 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11
SP1:							-
SP2:							-						-		-
SP3:							-						-		-
SP4:							-						-
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for TFE3

2 Ensembl transcripts including schematic representations:

ENST00000336239 ENST00000315869

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TFE3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TFE3

¹ / ² / ³

6 probe-sets matching TFE3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34669_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X96717	1.00	1.00	1.00	1
212457_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL161985	0.60	1.00	0.82	1
206649_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006521	0.60	1.00	0.82	1
1565347_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212457_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206649_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGGGTATAC

SOURCE GeneReport for Unigene cluster: Hs.274184
Expression variation in blood from EXPOLDB for TFE3
UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532
Tissue specificity: Ubiquitous in fetal and adult tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TFE3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TFE3¹	--	transcription factor binding to IGHM enhancer 3	92.54(n) 96.83(a)	491872 XM_858594.1 XP_863687.1
cow (Bos taurus)	TFE3¹	--	transcription factor binding to IGHM enhancer 3	93.15(n) 95.14(a)	520800 NM_001075811.1 NP_001069279.1
rat (Rattus norvegicus)	Tcfe3¹	--	transcription factor E3	89.01(n) 95.93(a)	317376 XM_228760.4 XP_228760.4
mouse (Mus musculus)	Tcfe3^{1, 5}	X (1.80 cM)⁵	transcription factor E3^{1, 5}	89.1(n)¹ 96.75(a)¹	209446¹ NM_172472.1¹ NP_766060.1¹ AF510653⁵ AI838186⁵ (see all 34)
zebrafish (Danio rerio)	tfe3a²	--	transcription factor binding to IGHM enhancer 3a	75.03(n)	114834 AF362684.1

About this table Species with no ortholog for TFE3

ENSEMBL Gene Tree for TFE3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TFE3 gene

MITF² TFEC² TFEB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in TFE3 are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3027473^1,2	C,F,H	48771044(-)	`AAGACA/TATATG`	1	--	ng5¹		4		EU EA WA	418
	rs3027474^1,2	F,H	48770801(-)	`AAAAAT/AGCCAC`	1	--	ng5¹		4		EU EA WA	418
	rs3950204^1,2	C	48788380(+)	`ATTTGC/TAATAT`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs5953258^1,2	H	48783823(+)	`CAGAAG/CACGAT`	1	C/S	mis¹ ese³		4		EU EA WA	414
	rs4824738^1,2	C	48787844(+)	`GCGTCG/TGGGAG`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs3027472^1,2	C,F	48773018(-)	`CCAGTA/GCCTCC`	1	V/V	syn¹ ese³		1		NA	76
	rs12012631^1,2	A,C,F,H	48787331(+)	`GCCCCG/TCTAGA`	1	--	int¹		4		EU EA WA	418
	rs7056903^1,2	C,F,H	48785127(+)	`GAGAGG/CGGGGG`	1	--	int¹		4		EU EA WA	416
	rs3027471^1,2	C,F,H	48778280(-)	`GCCTTC/ACTGTG`	1	--	int¹		9		NA EU EA WA	824
--	rs1209829^1,2	A,C	48777142(+)	`tttttG/Ttttgt`	1	--	int¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for TFE3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 314310 disorders: 605074

UniProtKB/Swiss-Prot: TFE3_HUMAN, P19532

Chromosomal aberrations involving TFE3 are recurrent in alveolar soft part sarcoma (ASPS)

[MIM:606243]. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein

Chromosomal aberrations involving TFE3 may be a cause of papillary renal cell carcinoma

(PRCC) [MIM:605074]. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34)

with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3

Chromosomal aberrations involving TFE3 are recurrent in alveolar soft part sarcoma (ASPS).

Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein

10 Novoseek disease relationships for TFE3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma alveolar soft part	85.78	11	12766578 (2), 18176180 (1), 12719541 (1), 12769020 (1) (see all 6)
carcinoma renal cell	77.01	37	12766578 (5), 12902986 (3), 11313942 (2), 17905124 (2) (see all 18)
microphthalmia	66.52	4	10707962 (2), 16327428 (1), 7479029 (1)
wiskott-aldrich syndrome	42.00	2	8666400 (1), 8104859 (1)
carcinoma	37.79	14	18344867 (3), 15316311 (3), 15848741 (1), 17478783 (1) (see all 6)
tumors	35.58	28	12766578 (4), 15316311 (2), 15848741 (1), 17580272 (1) (see all 16)
sarcoma	33.99	4	18176180 (1), 11244503 (1)
metastasis	22.73	2	12769020 (1), 17121199 (1)
cancer	0.00	2	11717438 (1), 16737956 (1)
leukemia	0.00	2	15994295 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/112 PubMed articles for TFE3 gene (see all 112 ):

The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. (PubMed id 11244503)^{1, 3, 4} Ladanyi M.... Bridge J. (2001)
The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22. (PubMed id 1685140)^{1, 2, 3} Henthorn P.S....Puck J.M. (1991)
Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. (PubMed id 9393982)^{1, 3, 4} Clark J.... Cooper C.S. (1997)
TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. (PubMed id 2338243)^{1, 3, 4} Beckmann H.... Kadesch T. (1990)
Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas. (PubMed id 11358836)^{1, 3, 4} Heimann P....Vassart G. (2001)
The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. (PubMed id 8872474)^{1, 3, 4} Sidhar S.K.... Cooper C.S. (1996)
Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. (PubMed id 8986805)^{3, 4} Weterman M.A.J.... Geurts van Kessel A. (1996)
A high-frequency RFLP at the human TFE3 locus on the X chromosome. (PubMed id 1672758)^{2, 3} Puck J.M....Henthorn P.S. (1991)
A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta. (PubMed id 16737956)^{1, 3} Nijman S.M....Bernards R. (2006)
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. (PubMed id 9765209)^{1, 3} Hua X....Lodish H.F. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7030	HGNC: 11752	AceView: TFE3	Ensembl:ENSG00000068323	euGenes: HUgn7030
ECgene: TFE3	H-InvDB: TFE3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TFE3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TFE3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TFE3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TFE3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TFE3		Antibodies for TFE3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TFE3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TFE3)
	Antibodies (TFE3)
	Chimera RNAi (TFE3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TFE3)
	Antibodies (TFE3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TFE3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TFE3

Summaries
for TFE3

Genomic Location
for TFE3

Proteins
for TFE3

Protein Domains/
Families
for TFE3

Gene Function
for TFE3

Pathways & Interactions
for TFE3

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for TFE3

Transcripts
for TFE3

Expression
for TFE3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TFE3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TFE3

Summariesfor TFE3

Genomic Locationfor TFE3

Proteinsfor TFE3

Protein Domains/Familiesfor TFE3

Gene Functionfor TFE3

Pathways & Interactionsfor TFE3

Drugs & Compoundsfor TFE3

Transcriptsfor TFE3

Expression for TFE3

Orthologsfor TFE3

Paralogsfor TFE3

SNPs/Variantsfor TFE3

Disorders & Mutationsfor TFE3

Medical Newsfor TFE3

Publicationsfor TFE3

Search for TFE3

Genome Databases showing TFE3

Other Databases showing TFE3

Specialized Databases showing TFE3

Licensable Technologiesfor TFE3

Servicesfor TFE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TFE3

Summaries
for TFE3

Genomic Location
for TFE3

Proteins
for TFE3

Protein Domains/
Families
for TFE3

Gene Function
for TFE3

Pathways & Interactions
for TFE3

Drugs & Compounds
for TFE3

Transcripts
for TFE3

Expression
for TFE3

Orthologs
for TFE3

Paralogs
for TFE3

SNPs/Variants
for TFE3

Disorders & Mutations
for TFE3

Medical News
for TFE3

Publications
for TFE3

Licensable Technologies
for TFE3

Services
for TFE3