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TFDP3 Gene

protein-coding   GIFtS: 44
GCID: GC0XM132350

Transcription Factor Dp Family, Member 3

  See TFDP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor Dp Family, Member 31 2     HCA6612 3 5
Cancer/Testis Antigen 301 2 3     E2F-Like Protein1 2
CT302 3 5     Hepatocellular Carcinoma-Associated Antigen 6612 3
DP42 3 5     Transcription Factor Dp Family Member 32

External Ids:    HGNC: 246031   Entrez Gene: 512702   Ensembl: ENSG000001834347   OMIM: 3007725   UniProtKB: Q5H9I03   

Export aliases for TFDP3 gene to outside databases

Previous GC identifers: GC0XM132076 GC0XM132178 GC0XM121755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFDP3 Gene:
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F
proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein
functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F
factors.(provided by RefSeq, May 2010)

GeneCards Summary for TFDP3 Gene:
TFDP3 (transcription factor Dp family, member 3) is a protein-coding gene. Diseases associated with TFDP3 include hepatocellular carcinoma. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle
progression from G(1) to S phase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFDP3 gene promoter:
         Max1   USF1   AML1a   HSF1 (long)   FOXD1   FOXL1   USF-1   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFDP3 promoter sequence
   Search Chromatin IP Primers for TFDP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFDP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.2

TFDP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132350:  view genomic region     (about GC identifiers)

Start:
132,350,697 bp from pter      End:
132,352,376 bp from pter
Size:
1,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0 (See protein sequence)
Recommended Name: Transcription factor Dp family member 3  
Size: 405 amino acids; 44967 Da
Subunit: Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent
transcriptional activity
Sequence caution: Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6DK49 Q9NZ54

Explore the universe of human proteins at neXtProt for TFDP3: NX_Q5H9I0

Explore proteomics data for TFDP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TFDP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057605.3  
    ENSEMBL proteins: 
     ENSP00000385461  

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    antibodies-online proteins for TFDP3 (4 products) 

     
    antibodies-online peptides for TFDP3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR014889 Transc_factor_DP_C
     IPR011991 WHTH_DNA-bd_dom
     IPR015648 Transcrpt_fac_DP
     IPR028315 TFDP3

    Graphical View of Domain Structure for InterPro Entry Q5H9I0

    ProtoNet protein and cluster: Q5H9I0

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
    Domain: The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind
    DNA
    Similarity: Belongs to the E2F/DP family


    Find genes that share domains with TFDP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFDP3_HUMAN, Q5H9I0
    Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle
    progression from G(1) to S phase
    Induction: In response to DNA damage

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046982protein heterodimerization activity IDA17062573
         
    Find genes that share ontologies with TFDP3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFDP3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TFDP3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFDP3_HUMAN, Q5H9I0: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family
    members
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IDA17062573

    Find genes that share ontologies with TFDP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFDP3
    Interactions:

        Search GeneGlobe Interaction Network for TFDP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TFDP3 (Q5H9I03 ENSP000003854614) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOCS3O145433I2D: score=1 
    CCNE1ENSP000002626434STRING: ENSP00000262643
    CCNE2ENSP000003091814STRING: ENSP00000309181
    MYBENSP000003399924STRING: ENSP00000339992
    MYBL2ENSP000002170264STRING: ENSP00000217026
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA17062573
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0007049cell cycle ----

    Find genes that share ontologies with TFDP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFDP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TFDP3 gene: 
    NM_016521.2  

    Unigene Cluster for TFDP3:

    Transcription factor Dp family, member 3
    Hs.142908  [show with all ESTs]
    Unigene Representative Sequence: NM_016521
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310125(uc004exb.1)
    miRNA
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    1 DOTS entry:

    DT.40242341 

    5 AceView cDNA sequences:

    AF219119 NM_016521 BU188531 BC074762 AA860918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFDP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TFDP3 Expression
    About this image

    TFDP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFDP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142908

    UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
    Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in
    ovarian and colon cancer cell lines

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFDP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    67(a)
    1 → many
    1(136646832-136674075)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    3(106250490-106306788)
    zebrafish
    (Danio rerio)
    Actinopterygii tfdp1a6
    transcription factor Dp-1, a
    60(a)
    1 → many
    9(35922246-35939949) ENSDARG00000019293
    fruit fly
    (Drosophila melanogaster)
    Insecta Dp6
    DP transcription factor
    29(a)
    1 → many
    2R(9109938-9115707)
    worm
    (Caenorhabditis elegans)
    Secernentea dpl-16
    Protein DPL-1 (dpl-1) mRNA, complete cds
    19(a)
    1 → many
    II(9169910-9172563) WBGene00001061
            Species with no ortholog for TFDP3

    ENSEMBL Gene Tree for TFDP3 (if available)
    TreeFam Gene Tree for TFDP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFDP3 gene
    TFDP12  TFDP22  
    2 SIMAP similar genes for TFDP3 using alignment to 1 protein entry:     TFDP3_HUMAN:
    TFDP1    TFDP2

    Find genes that share paralogs with TFDP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFDP3 (see all 106)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812163991,2
    --132307439(+) TAACAA/GACTGG 1 -- ds50010--------
    rs1405431021,2
    --132307658(+) ATCCAC/TTGATG 1 -- ds50010--------
    rs2006374181,2
    --132307709(+) ACCTC-/TTTTTT 1 -- ds50010--------
    rs1858754831,2
    --132307715(+) TTTTTC/TTTTAA 1 -- ds50010--------
    rs1456515031,2
    C--132307824(+) TATGCA/GTCAGT 1 -- ds50010--------
    rs1381849411,2
    C--132308075(+) AGCACA/GTCTTA 1 -- ut310--------
    rs1904487491,2
    --132308087(+) TCATAC/GGGGAA 1 -- ut310--------
    rs1118847151,2
    C--132308187(+) ACATT-/A/AA  
            
    AAAAA
    2 -- ut311CSA 2
    rs1830619341,2
    C--132308284(+) AGGTCA/GTCATC 2 D syn10--------
    rs1889141781,2
    --132308381(+) GCATCC/TCAATC 2 E G mis10--------

    HapMap Linkage Disequilibrium report for TFDP3 (132350697 - 132352376 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TFDP3: --
    Locus Specific Mutation Databases (LSDB): TFDP3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFDP3
    DNA2.0 Custom Variant and Variant Library Synthesis for TFDP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300772    OMIM disorders: --

    1 disease for TFDP3:    
    About MalaCards
    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for TFDP3:
    Malignant hyperthermia

    Find genes that share disorders with TFDP3           About GenesLikeMe


    Export disorders for TFDP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFDP3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TFDP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (J. Immunol. 2002)
    2. E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. (PubMed id 20559320)1, 2 Ingram L.... La Thangue N.B. (Cell Death Differ. 2011)
    3. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. (PubMed id 17062573)1, 2 Qiao H.... Chen W.F. (J. Biol. Chem. 2007)
    4. A functionally distinct member of the DP family of E2F subunits. (PubMed id 16418725)1, 2 Milton A.... La Thangue N.B. (Oncogene 2006)
    5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    6. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. (PubMed id 23212661)1 Sun H.X....Fan J. (Hepatology 2013)
    7. [Effects of TFDP3 on regulating the autophagy and apoptosis of LNCaP cells]. (PubMed id 22482402)1 Ren L.F....Hao X.K. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. TFDP3 inhibits E2F1-induced, p53-mediated apoptosis. (PubMed id 17632080)1 Tian C....Chen W.F. (Biochem. Biophys. Res. Commun. 2007)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51270 HGNC: 24603 AceView: TFDP3 Ensembl:ENSG00000183434 euGenes: HUgn51270
    ECgene: TFDP3 H-InvDB: TFDP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFDP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFDP3 gene:
    Search GeneIP for patents involving TFDP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Antibodies for TFDP3   OriGene RNAi products in human, mouse, rat for TFDP3  
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     Block miRNA regulation of human, mouse, rat TFDP3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TFDP3
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TFDP3
     Gene Synthesis
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     Browse compounds at ApexBio
     Search Addgene for plasmids for TFDP3
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     genOway: Develop your customized and physiologically relevant rodent model for TFDP3
     antibodies-online antibodies for TFDP3 (38 products)
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