Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TFDP3 Gene

Aliases for TFDP3 Gene

  • Transcription Factor Dp Family Member 3 2 3 5
  • Cancer/Testis Antigen 30 2 3 4
  • Hepatocellular Carcinoma-Associated Antigen 661 3 4
  • Transcription Factor Dp Family, Member 3 2 3
  • E2F-Like Protein 2 3
  • HCA661 3 4
  • CT30 3 4
  • DP4 3 4

External Ids for TFDP3 Gene

Previous GeneCards Identifiers for TFDP3 Gene

  • GC0XM132076
  • GC0XM132178
  • GC0XM132350
  • GC0XM121755

Summaries for TFDP3 Gene

Entrez Gene Summary for TFDP3 Gene

  • This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]

GeneCards Summary for TFDP3 Gene

TFDP3 (Transcription Factor Dp Family Member 3) is a Protein Coding gene. Diseases associated with TFDP3 include hepatocellular carcinoma and berylliosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TFDP2.

UniProtKB/Swiss-Prot for TFDP3 Gene

  • Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP3 Gene

Genomics for TFDP3 Gene

Regulatory Elements for TFDP3 Gene

Genomic Location for TFDP3 Gene

Chromosome:
X
Start:
133,216,669 bp from pter
End:
133,218,348 bp from pter
Size:
1,680 bases
Orientation:
Minus strand

Genomic View for TFDP3 Gene

Genes around TFDP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP3 Gene

Proteins for TFDP3 Gene

  • Protein details for TFDP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9I0-TFDP3_HUMAN
    Recommended name:
    Transcription factor Dp family member 3
    Protein Accession:
    Q5H9I0
    Secondary Accessions:
    • Q6DK49
    • Q9NZ54

    Protein attributes for TFDP3 Gene

    Size:
    405 amino acids
    Molecular mass:
    44967 Da
    Quaternary structure:
    • Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent transcriptional activity.
    SequenceCaution:
    • Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TFDP3 Gene

Proteomics data for TFDP3 Gene at MOPED

Post-translational modifications for TFDP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFDP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFDP3 Gene

Domains & Families for TFDP3 Gene

Gene Families for TFDP3 Gene

Suggested Antigen Peptide Sequences for TFDP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9I0

UniProtKB/Swiss-Prot:

TFDP3_HUMAN :
  • The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind DNA.
  • Belongs to the E2F/DP family.
Domain:
  • The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind DNA.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP3: view

Function for TFDP3 Gene

Molecular function for TFDP3 Gene

UniProtKB/Swiss-Prot Function:
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
UniProtKB/Swiss-Prot Induction:
In response to DNA damage.
genes like me logo Genes that share phenotypes with TFDP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFDP3 Gene

Localization for TFDP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP3 Gene

Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFDP3 Gene COMPARTMENTS Subcellular localization image for TFDP3 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TFDP3 Gene

Pathways & Interactions for TFDP3 Gene

SuperPathways for TFDP3 Gene

No Data Available

Interacting Proteins for TFDP3 Gene

Gene Ontology (GO) - Biological Process for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TFDP3: view

No data available for Pathways by source and SIGNOR curated interactions for TFDP3 Gene

Drugs & Compounds for TFDP3 Gene

No Compound Related Data Available

Transcripts for TFDP3 Gene

mRNA/cDNA for TFDP3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFDP3 Gene

Transcription factor Dp family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP3 Gene

No ASD Table

Relevant External Links for TFDP3 Gene

GeneLoc Exon Structure for
TFDP3
ECgene alternative splicing isoforms for
TFDP3

Expression for TFDP3 Gene

mRNA expression in normal human tissues for TFDP3 Gene

mRNA differential expression in normal tissues according to GTEx for TFDP3 Gene

This gene is overexpressed in Testis (x49.8).

SOURCE GeneReport for Unigene cluster for TFDP3 Gene Hs.142908

mRNA Expression by UniProt/SwissProt for TFDP3 Gene

Q5H9I0-TFDP3_HUMAN
Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.
genes like me logo Genes that share expression patterns with TFDP3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TFDP3 Gene

Orthologs for TFDP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFDP3 36
  • 95 (a)
OneToOne
TFDP3 35
  • 98.02 (n)
  • 95.06 (a)
cow
(Bos Taurus)
Mammalia TFDP1 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tfdp1 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tfdp1a 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dp 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpl-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 36
  • 31 (a)
OneToMany
Species with no ortholog for TFDP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TFDP3 Gene

ENSEMBL:
Gene Tree for TFDP3 (if available)
TreeFam:
Gene Tree for TFDP3 (if available)

Paralogs for TFDP3 Gene

Paralogs for TFDP3 Gene

(2) SIMAP similar genes for TFDP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFDP3: view

Variants for TFDP3 Gene

Sequence variations from dbSNP and Humsavar for TFDP3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6638058 -- 133,218,489(+) GTGTG(C/T)GGTAC upstream-variant-2KB
rs6638059 -- 133,218,490(+) TGTGT(A/G)GTACG upstream-variant-2KB
rs61732904 -- 133,217,821(+) GGCGT(A/G)GTTGC reference, missense
rs35745873 -- 133,217,675(-) GCTCA(C/G/T)AACTG reference, missense
rs73638807 -- 133,218,904(+) CTAAG(A/C)CTTCC upstream-variant-2KB

Variation tolerance for TFDP3 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFDP3 Gene

HapMap Linkage Disequilibrium report
TFDP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TFDP3 Gene

Disorders for TFDP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TFDP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
berylliosis
  • beryllium poisoning
- elite association - COSMIC cancer census association via MalaCards
Search TFDP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFDP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFDP3
genes like me logo Genes that share disorders with TFDP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFDP3 Gene

Publications for TFDP3 Gene

  1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer. (PMID: 24406621) Ma Y. … Hao X. (Gene 2014) 3
  4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3
  5. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. (PMID: 23212661) Sun H.X. … Fan J. (Hepatology 2013) 3

Products for TFDP3 Gene

Sources for TFDP3 Gene

Back to Top

Content