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Aliases for TFDP3 Gene

Aliases for TFDP3 Gene

  • Transcription Factor Dp Family, Member 3 2 3
  • Cancer/Testis Antigen 30 2 3 4
  • HCA661 3 4 6
  • CT30 3 4 6
  • DP4 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 661 3 4
  • E2F-Like Protein 2 3
  • Transcription Factor Dp Family Member 3 3

External Ids for TFDP3 Gene

Previous GeneCards Identifiers for TFDP3 Gene

  • GC0XM132076
  • GC0XM132178
  • GC0XM132350
  • GC0XM121755

Summaries for TFDP3 Gene

Entrez Gene Summary for TFDP3 Gene

  • This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]

GeneCards Summary for TFDP3 Gene

TFDP3 (Transcription Factor Dp Family, Member 3) is a Protein Coding gene. Diseases associated with TFDP3 include hepatocellular carcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TFDP2.

UniProtKB/Swiss-Prot for TFDP3 Gene

  • Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP3 Gene

Genomics for TFDP3 Gene

Regulatory Elements for TFDP3 Gene

Genomic Location for TFDP3 Gene

Start:
133,216,669 bp from pter
End:
133,218,348 bp from pter
Size:
1,680 bases
Orientation:
Minus strand

Genomic View for TFDP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFDP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP3 Gene

Proteins for TFDP3 Gene

  • Protein details for TFDP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9I0-TFDP3_HUMAN
    Recommended name:
    Transcription factor Dp family member 3
    Protein Accession:
    Q5H9I0
    Secondary Accessions:
    • Q6DK49
    • Q9NZ54

    Protein attributes for TFDP3 Gene

    Size:
    405 amino acids
    Molecular mass:
    44967 Da
    Quaternary structure:
    • Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent transcriptional activity.
    SequenceCaution:
    • Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TFDP3 Gene

Proteomics data for TFDP3 Gene at MOPED

Post-translational modifications for TFDP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFDP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFDP3 Gene

Domains for TFDP3 Gene

Suggested Antigen Peptide Sequences for TFDP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9I0

UniProtKB/Swiss-Prot:

TFDP3_HUMAN :
  • Q5H9I0
Domain:
  • The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind DNA
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP3: view

No data available for Gene Families for TFDP3 Gene

Function for TFDP3 Gene

Molecular function for TFDP3 Gene

UniProtKB/Swiss-Prot Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
UniProtKB/Swiss-Prot Induction: In response to DNA damage.

Gene Ontology (GO) - Molecular Function for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0046982 protein heterodimerization activity IDA 17062573
genes like me logo Genes that share ontologies with TFDP3: view

Phenotypes for TFDP3 Gene

GenomeRNAi human phenotypes for TFDP3:
genes like me logo Genes that share phenotypes with TFDP3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TFDP3 Gene

Localization for TFDP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP3 Gene

Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFDP3 Gene COMPARTMENTS Subcellular localization image for TFDP3 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA 17062573
genes like me logo Genes that share ontologies with TFDP3: view

Pathways for TFDP3 Gene

SuperPathways for TFDP3 Gene

No Data Available

Interacting Proteins for TFDP3 Gene

Gene Ontology (GO) - Biological Process for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 17062573
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with TFDP3: view

No data available for Pathways by source for TFDP3 Gene

Transcripts for TFDP3 Gene

mRNA/cDNA for TFDP3 Gene

(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFDP3 Gene

Transcription factor Dp family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP3 Gene

No ASD Table

Relevant External Links for TFDP3 Gene

GeneLoc Exon Structure for
TFDP3
ECgene alternative splicing isoforms for
TFDP3

Expression for TFDP3 Gene

mRNA expression in normal human tissues for TFDP3 Gene

mRNA differential expression in normal tissues according to GTEx for TFDP3 Gene

This gene is overexpressed in Testis (49.8).

SOURCE GeneReport for Unigene cluster for TFDP3 Gene Hs.142908

mRNA Expression by UniProt/SwissProt for TFDP3 Gene

Q5H9I0-TFDP3_HUMAN
Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.
genes like me logo Genes that share expressions with TFDP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for TFDP3 Gene

Orthologs for TFDP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFDP3 35
  • 98.02 (n)
  • 95.06 (a)
TFDP3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFDP1 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tfdp1 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tfdp1a 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dp 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpl-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 36
  • 31 (a)
OneToMany
Species with no ortholog for TFDP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TFDP3 Gene

ENSEMBL:
Gene Tree for TFDP3 (if available)
TreeFam:
Gene Tree for TFDP3 (if available)

Paralogs for TFDP3 Gene

Paralogs for TFDP3 Gene

Selected SIMAP similar genes for TFDP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFDP3: view

Variants for TFDP3 Gene

Sequence variations from dbSNP and Humsavar for TFDP3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6634920 -- 133,218,509(+) GGTAC(C/G)TGGTG upstream-variant-2KB
rs6638058 -- 133,218,489(+) GTGTG(C/T)GGTAC upstream-variant-2KB
rs6638059 -- 133,218,490(+) TGTGT(A/G)GTACG upstream-variant-2KB
rs28455963 -- 133,218,202(+) GTTCT(C/G)GTCCA missense, reference
rs35745873 -- 133,217,675(-) GCTCA(G/T)AACTG reference, missense

Relevant External Links for TFDP3 Gene

HapMap Linkage Disequilibrium report
TFDP3
Locus Specific Mutation Databases (LSDB)
TFDP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TFDP3 Gene

Disorders for TFDP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TFDP3 Gene including...

Search for TFDP3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TFDP3 Gene

genes like me logo Genes that share disorders with TFDP3: view

No data available for UniProtKB/Swiss-Prot for TFDP3 Gene

Publications for TFDP3 Gene

  1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 2 3 4
  2. A functionally distinct member of the DP family of E2F subunits. (PMID: 16418725) Milton A. … La Thangue N.B. (Oncogene 2006) 3 4
  3. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. (PMID: 17062573) Qiao H. … Chen W.F. (J. Biol. Chem. 2007) 3 4
  4. E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. (PMID: 20559320) Ingram L. … La Thangue N.B. (Cell Death Differ. 2011) 3 4
  5. [Effects of TFDP3 on regulating the autophagy and apoptosis of LNCaP cells]. (PMID: 22482402) Ren L.F. … Hao X.K. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012) 3

Products for TFDP3 Gene

Sources for TFDP3 Gene

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