TFDP3 Gene
protein-coding GIFtS: 46
GCID: GC0XM132350
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|
transcription factor Dp family, member 3
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Aliases
for TFDP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Factor Dp Family, Member 31 2 | | Hepatocellular Carcinoma-Associated Antigen 6612 3 | | CT301 2 3 5 | | E2F-Like1 | | HCA6611 2 3 5 | | E2F-Like Protein2 | | DP42 3 5 | | Transcription Factor Dp Family Member 32 | | Cancer/Testis Antigen 302 3 | | |
Export aliases for TFDP3 gene to outside databasesPrevious GC identifers: GC0XM132076 GC0XM132178 GC0XM121755 |
Summaries
for TFDP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TFDP3:
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins toenhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as anegative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.(provided by RefSeq, May2010)
UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progressionfrom G(1) to S phase
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Genomic Views
for TFDP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TFDP3 gene promoter:
Max1 USF1 AML1a HSF1 (long) FOXD1 FOXL1 USF-1 HSF1short c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TFDP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.2 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq26.2TFDP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM132350: view genomic region
(about GC identifiers)
Start:
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132,350,697 bp from pter |
End:
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132,352,376 bp from pter |
Size:
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1,680 bases |
Orientation:
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minus strand |
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Proteins
for TFDP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0 (See
protein sequence)Recommended Name: Transcription factor Dp family member 3 Size: 405 amino acids; 44967 Da
Subunit: Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependenttranscriptional activity
Subcellular location: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F familymembers
Sequence caution: Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6DK49 Q9NZ54Explore the universe of human proteins at neXtProt for TFDP3: NX_Q5H9I0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5H9I0
TFDP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057605.3
ENSEMBL proteins: ENSP00000385461
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TFDP3 for ontologies About GeneDecksing
TFDP3 Antibody Products:
Assay Products for TFDP3: |
Protein
Domains /
Families
for TFDP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TFDP3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5H9I0ProtoNet protein and cluster: Q5H9I0 1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)
UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0Domain: The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind DNASimilarity: Belongs to the E2F/DP family |
Function
for TFDP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progressionfrom G(1) to S phaseInduction: In response to DNA damage
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IDA | 17062573 |
TFDP3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TFDP3:
|
Pathways & Interactions
for TFDP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TFDP3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TFDP3 (Q5H9I03 ENSP000003854614) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IDA | 17062573 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006974 | response to DNA damage stimulus |
IDA | -- |
TFDP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TFDP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TFDP3
Search CenterWatch for drugs/clinical trials and news about TFDP3
|
Transcripts
for TFDP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TFDP3 gene: NM_016521.2 Unigene Cluster for TFDP3: Transcription factor Dp family, member 3 Hs.142908 [show with all ESTs]Unigene Representative Sequence: NM_0165211 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000310125(uc004exb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TFDP3 (NM_016521) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TFDP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP3 |
1 DOTS entry: DT.40242341 5 AceView cDNA sequences: AF219119 BU188531 BC074762 NM_016521 AA860918
GeneLoc Exon Structure
|
Expression
for TFDP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TFDP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TFDP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFDP3
SOURCE GeneReport for Unigene cluster: Hs.142908
UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarianand colon cancer cell lines
SABiosciences Custom PCR Arrays for TFDP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFDP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TFDP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFDP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFDP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP3 |
Orthologs
for TFDP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TFDP3 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for TFDP3 (if available)
TreeFam Gene Tree for TFDP3 (if available) |
Paralogs
for TFDP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TFDP3 gene
- TFDP12 TFDP22
3 SIMAP similar genes for TFDP3 using alignment to 1 protein entry: TFDP3_HUMAN:TFDP1 DKFZp434G222 TFDP2
TFDP3 for paralogs About GeneDecksing
|
Genomic Variants
for TFDP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TFDP3 (132350697 - 132352376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TFDP3: --
Locus Specific Mutation Databases (LSDB): TFDP3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFDP3 |
|
Disorders
/ Diseases
for TFDP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TFDP3 for disorders About GeneDecksing
OMIM gene information: 300772
OMIM disorders: --
3  diseases for TFDP3: About MalaCardshepatocellular carcinoma carcinoma colon cancer
1 disease from the University of Copenhagen DISEASES database for TFDP3:Malignant hyperthermia Export disorders for TFDP3 gene to outside databases
|
Publications
for TFDP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TFDP3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TFDP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (2002)
- E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. (PubMed id 20559320)1, 2 Ingram L.... La Thangue N.B. (2011)
- Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. (PubMed id 17062573)1, 2 Qiao H....Chen W.F. (2007)
- A functionally distinct member of the DP family of E2F subunits. (PubMed id 16418725)1, 2 Milton A....La Thangue N.B. (2006)
- [Effects of TFDP3 on regulating the autophagy and apop tosis of LNCaP cells]. (PubMed id 22482402)1 Ren L.F....Hao X.K. (2012)
- TFDP3 inhibits E2F1-induced, p53-mediated apoptosis. (PubMed id 17632080)1 Tian C....Chen W.F. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TFDP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TFDP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TFDP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TFDP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TFDP3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TFDP3 gene:
Search GeneIP for patents involving TFDP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TFDP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP3 |
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