Aliases for TFDP3 Gene
External Ids for TFDP3 Gene
Previous GeneCards Identifiers for TFDP3 Gene
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]
GeneCards Summary for TFDP3 Gene
TFDP3 (Transcription Factor Dp Family Member 3) is a Protein Coding gene. Diseases associated with TFDP3 include hepatocellular carcinoma and berylliosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TFDP2.
UniProtKB/Swiss-Prot for TFDP3 Gene
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.