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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFDP3 Gene

protein-coding   GIFtS: 44
GCID: GC0XM132350

Transcription Factor Dp Family, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor Dp Family, Member 31 2     HCA6612 3 5
Cancer/Testis Antigen 301 2 3     E2F-Like Protein1 2
CT302 3 5     Hepatocellular Carcinoma-Associated Antigen 6612 3
DP42 3 5     Transcription Factor Dp Family Member 32

External Ids:    HGNC: 246031   Entrez Gene: 512702   Ensembl: ENSG000001834347   OMIM: 3007725   UniProtKB: Q5H9I03   

Export aliases for TFDP3 gene to outside databases

Previous GC identifers: GC0XM132076 GC0XM132178 GC0XM121755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFDP3 Gene:
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F
proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein
functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F
factors.(provided by RefSeq, May 2010)

GeneCards Summary for TFDP3 Gene: 
TFDP3 (transcription factor Dp family, member 3) is a protein-coding gene. Diseases associated with TFDP3 include malignant hyperthermia, and hepatocellular carcinoma. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle
progression from G(1) to S phase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFDP3 gene promoter:
         Max1   USF1   AML1a   HSF1 (long)   FOXD1   FOXL1   USF-1   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFDP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TFDP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.2

TFDP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132350:  view genomic region     (about GC identifiers)

Start:
132,350,697 bp from pter      End:
132,352,376 bp from pter
Size:
1,680 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0 (See protein sequence)
Recommended Name: Transcription factor Dp family member 3  
Size: 405 amino acids; 44967 Da
Subunit: Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent
transcriptional activity
Subcellular location: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family
members
Sequence caution: Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6DK49 Q9NZ54

Explore the universe of human proteins at neXtProt for TFDP3: NX_Q5H9I0

Explore proteomics data for TFDP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5H9I0

  • TFDP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFDP3 Protein Expression
    REFSEQ proteins: NP_057605.3  
    ENSEMBL proteins: 
     ENSP00000385461  

    Human Recombinant Protein Products for TFDP3: 
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    Novus Biologicals TFDP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFDP3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IDA17062573

    TFDP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR014889 Transc_factor_DP_C
     IPR011991 WHTH_DNA-bd_dom
     IPR015648 Transcrpt_fac_DP
     IPR016556 Transcription_factor_DP_subgr

    Graphical View of Domain Structure for InterPro Entry Q5H9I0

    ProtoNet protein and cluster: Q5H9I0

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
    Domain: The potential DNA-binding domain differs in sequence from that of other DP family members and can not bind
    DNA
    Similarity: Belongs to the E2F/DP family


    TFDP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFDP3_HUMAN, Q5H9I0
    Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle
    progression from G(1) to S phase
    Induction: In response to DNA damage

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046982protein heterodimerization activity IDA17062573
         
    TFDP3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TFDP3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFDP3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TFDP3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TFDP3 (Q5H9I03 ENSP000003854614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOCS3O145433I2D: score=1 
    E2F5ENSP000003981244STRING: ENSP00000398124
    E2F4ENSP000003686864STRING: ENSP00000368686
    RB1ENSP000002671634STRING: ENSP00000267163
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA17062573
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006974response to DNA damage stimulus IDA--

    TFDP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFDP3

    Search CenterWatch for drugs/clinical trials and news about TFDP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFDP3 gene: 
    NM_016521.2  

    Unigene Cluster for TFDP3:

    Transcription factor Dp family, member 3
    Hs.142908  [show with all ESTs]
    Unigene Representative Sequence: NM_016521
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310125(uc004exb.1)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFDP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFDP3

    1 DOTS entry:

    DT.40242341 

    5 AceView cDNA sequences:

    NM_016521 BU188531 AF219119 BC074762 AA860918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFDP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TFDP3 Expression
    About this image


    See TFDP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFDP3

    SOURCE GeneReport for Unigene cluster: Hs.142908

    UniProtKB/Swiss-Prot: TFDP3_HUMAN, Q5H9I0
    Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in
    ovarian and colon cancer cell lines

        SABiosciences Custom PCR Arrays for TFDP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TFDP3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TFDP16
    Uncharacterized protein
    67(a)
    1 → many
    1(136646832-136674075)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    68(a)
    1 → many
    3(106250490-106306788)
    zebrafish
    (Danio rerio)
    Actinopterygii tfdp1a6
    tfdp1b6
    transcription factor Dp-1, b
    60(a)
    49(a)
    many ↔ many
    many ↔ many
    9(35922246-35939949)
    1(101973-116398)
    fruit fly
    (Drosophila melanogaster)
    Insecta Dp6
    DP transcription factor
    26(a)
    1 → many
    2R(9109938-9115707)
    worm
    (Caenorhabditis elegans)
    Secernentea dpl-16
    Transcription factor dpl-1
    18(a)
    1 → many
    II(9169908-9172563)
            Species with no ortholog for TFDP3

    ENSEMBL Gene Tree for TFDP3 (if available)
    TreeFam Gene Tree for TFDP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFDP3 gene
    TFDP12  TFDP22  
    2 SIMAP similar genes for TFDP3 using alignment to 1 protein entry:     TFDP3_HUMAN:
    TFDP1    TFDP2

    TFDP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 SNPs in TFDP3 are shown (see all 106)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812163991,2
    --132307439(+) TAACAA/GACTGG 1 -- ds50010--------
    rs1405431021,2
    --132307658(+) ATCCAC/TTGATG 1 -- ds50010--------
    rs2006374181,2
    --132307709(+) ACCTC-/TTTTTT 1 -- ds50010--------
    rs1858754831,2
    --132307715(+) TTTTTC/TTTTAA 1 -- ds50010--------
    rs1456515031,2
    C--132307824(+) TATGCA/GTCAGT 1 -- ds50010--------
    rs1381849411,2
    C--132308075(+) AGCACA/GTCTTA 1 -- ut310--------
    rs1904487491,2
    --132308087(+) TCATAC/GGGGAA 1 -- ut310--------
    rs1118847151,2
    C--132308187(+) ACATT-/A/AA  
            
    AAAAA
    2 -- ut311CSA 2
    rs1830619341,2
    C--132308284(+) AGGTCA/GTCATC 2 D syn10--------
    rs1889141781,2
    --132308381(+) GCATCC/TCAATC 2 E G mis10--------

    HapMap Linkage Disequilibrium report for TFDP3 (132350697 - 132352376 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TFDP3: --

    Locus Specific Mutation Databases (LSDB): TFDP3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TFDP3
    DNA2.0 Custom Variant and Variant Library Synthesis for TFDP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300772    OMIM disorders: --

    3 diseases for TFDP3:    About MalaCards
    malignant hyperthermia    hepatocellular carcinoma    colon cancer

    1 disease from the University of Copenhagen DISEASES database for TFDP3:
    Malignant hyperthermia

    TFDP3 for disorders           About GeneDecksing


    Export disorders for TFDP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFDP3 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TFDP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (2002)
    2. E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. (PubMed id 20559320)1, 2 Ingram L.... La Thangue N.B. (2011)
    3. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. (PubMed id 17062573)1, 2 Qiao H....Chen W.F. (2007)
    4. A functionally distinct member of the DP family of E2F subunits. (PubMed id 16418725)1, 2 Milton A....La Thangue N.B. (2006)
    5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    6. Hypoxia inducible factor 2 alpha inhibits hepatocellul ar carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. (PubMed id 23212661)1 Sun H.X....Fan J. (2013)
    7. [Effects of TFDP3 on regulating the autophagy and apop tosis of LNCaP cells]. (PubMed id 22482402)1 Ren L.F....Hao X.K. (2012)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. TFDP3 inhibits E2F1-induced, p53-mediated apoptosis. (PubMed id 17632080)1 Tian C....Chen W.F. (2007)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51270 HGNC: 24603 AceView: TFDP3 Ensembl:ENSG00000183434 euGenes: HUgn51270
    ECgene: TFDP3 H-InvDB: TFDP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFDP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFDP3 gene:
    Search GeneIP for patents involving TFDP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Regulatory tfbs in TFDP3 promoter
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     Proteins for TFDP3
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TFDP3
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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