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Aliases for TFDP3 Gene

Aliases for TFDP3 Gene

  • Transcription Factor Dp Family Member 3 2 3 5
  • Cancer/Testis Antigen 30 2 3 4
  • Hepatocellular Carcinoma-Associated Antigen 661 3 4
  • E2F-Like Protein 2 3
  • HCA661 3 4
  • CT30 3 4
  • DP4 3 4
  • Transcription Factor Dp Family, Member 3 2

External Ids for TFDP3 Gene

Previous GeneCards Identifiers for TFDP3 Gene

  • GC0XM132076
  • GC0XM132178
  • GC0XM132350
  • GC0XM121755

Summaries for TFDP3 Gene

Entrez Gene Summary for TFDP3 Gene

  • This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]

GeneCards Summary for TFDP3 Gene

TFDP3 (Transcription Factor Dp Family Member 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot for TFDP3 Gene

  • Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.

Additional gene information for TFDP3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP3 Gene

Genomics for TFDP3 Gene

Regulatory Elements for TFDP3 Gene

Enhancers for TFDP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH133186 0.6 ENCODE 0.3 +32.2 32181 0 SOX5 SOX13 ESRRA JUND FOXA2 NFIA ZKSCAN1 ENSG00000207100 TFDP3
GH0XH133189 0.3 FANTOM5 0.3 +28.9 28931 0 HS6ST2 USP26 GPC4 TFDP3 ENSG00000207100
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TFDP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TFDP3 Gene

Chromosome:
X
Start:
133,216,669 bp from pter
End:
133,218,348 bp from pter
Size:
1,680 bases
Orientation:
Minus strand

Genomic View for TFDP3 Gene

Genes around TFDP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP3 Gene

Proteins for TFDP3 Gene

  • Protein details for TFDP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9I0-TFDP3_HUMAN
    Recommended name:
    Transcription factor Dp family member 3
    Protein Accession:
    Q5H9I0
    Secondary Accessions:
    • Q6DK49
    • Q9NZ54

    Protein attributes for TFDP3 Gene

    Size:
    405 amino acids
    Molecular mass:
    44967 Da
    Quaternary structure:
    • Heterodimer: with E2F family members. TFDP3/E2F heterodimers do not bind DNA and repress E2F-dependent transcriptional activity.
    SequenceCaution:
    • Sequence=AAF37562.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TFDP3 Gene

Post-translational modifications for TFDP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFDP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFDP3 Gene

Domains & Families for TFDP3 Gene

Gene Families for TFDP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TFDP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9I0

UniProtKB/Swiss-Prot:

TFDP3_HUMAN :
  • The potential DNA-binding domain differs in sequence from that of other DP family members and cannot bind DNA.
  • Belongs to the E2F/DP family.
Domain:
  • The potential DNA-binding domain differs in sequence from that of other DP family members and cannot bind DNA.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP3: view

Function for TFDP3 Gene

Molecular function for TFDP3 Gene

UniProtKB/Swiss-Prot Function:
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
UniProtKB/Swiss-Prot Induction:
In response to DNA damage.

Gene Ontology (GO) - Molecular Function for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046982 protein heterodimerization activity IDA 17062573
genes like me logo Genes that share ontologies with TFDP3: view
genes like me logo Genes that share phenotypes with TFDP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TFDP3
  • Applied Biological Materials Clones for TFDP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFDP3 Gene

Localization for TFDP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP3 Gene

Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFDP3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA,IEA 17062573
genes like me logo Genes that share ontologies with TFDP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TFDP3 Gene

Pathways & Interactions for TFDP3 Gene

SuperPathways for TFDP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFDP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 17062573
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006974 cellular response to DNA damage stimulus IDA 20559320
genes like me logo Genes that share ontologies with TFDP3: view

No data available for Pathways by source and SIGNOR curated interactions for TFDP3 Gene

Drugs & Compounds for TFDP3 Gene

No Compound Related Data Available

Transcripts for TFDP3 Gene

mRNA/cDNA for TFDP3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFDP3 Gene

Transcription factor Dp family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TFDP3
  • Applied Biological Materials Clones for TFDP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP3 Gene

No ASD Table

Relevant External Links for TFDP3 Gene

GeneLoc Exon Structure for
TFDP3
ECgene alternative splicing isoforms for
TFDP3

Expression for TFDP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TFDP3 Gene

mRNA differential expression in normal tissues according to GTEx for TFDP3 Gene

This gene is overexpressed in Testis (x49.8).

NURSA nuclear receptor signaling pathways regulating expression of TFDP3 Gene:

TFDP3

SOURCE GeneReport for Unigene cluster for TFDP3 Gene:

Hs.142908

mRNA Expression by UniProt/SwissProt for TFDP3 Gene:

Q5H9I0-TFDP3_HUMAN
Tissue specificity: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.
genes like me logo Genes that share expression patterns with TFDP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFDP3 Gene

Orthologs for TFDP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFDP3 33 34
  • 98.02 (n)
mouse
(Mus musculus)
Mammalia Tfdp1 34
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TFDP1 34
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tfdp1a 34
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dp 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpl-1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 34
  • 31 (a)
OneToMany
Species where no ortholog for TFDP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TFDP3 Gene

ENSEMBL:
Gene Tree for TFDP3 (if available)
TreeFam:
Gene Tree for TFDP3 (if available)

Paralogs for TFDP3 Gene

Paralogs for TFDP3 Gene

(2) SIMAP similar genes for TFDP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFDP3: view

Variants for TFDP3 Gene

Sequence variations from dbSNP and Humsavar for TFDP3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001551006 -- 133,216,625(+) GGGTG(C/T)CATCC downstream-variant-500B
rs1001919174 -- 133,218,304(+) TTTCC(A/G)GAGAA utr-variant-5-prime
rs1002268076 -- 133,218,541(+) CCTGG(C/T)GTAAC upstream-variant-2KB
rs1003998125 -- 133,220,014(+) GGGAT(G/T)ACAGG upstream-variant-2KB
rs1005119239 -- 133,219,567(+) TCCTA(A/G)AGACC upstream-variant-2KB

Variation tolerance for TFDP3 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFDP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFDP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TFDP3 Gene

Disorders for TFDP3 Gene

Relevant External Links for TFDP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFDP3

No disorders were found for TFDP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TFDP3 Gene

Publications for TFDP3 Gene

  1. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PMID: 12097419) Wang Y … Chen WF (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 60
  2. E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit. (PMID: 20559320) Ingram L … La Thangue NB (Cell death and differentiation 2011) 3 4 60
  3. Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. (PMID: 17062573) Qiao H … Chen WF (The Journal of biological chemistry 2007) 3 4 60
  4. A functionally distinct member of the DP family of E2F subunits. (PMID: 16418725) Milton A … La Thangue NB (Oncogene 2006) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TFDP3 Gene

  • Addgene plasmids for TFDP3

Sources for TFDP3 Gene

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