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Aliases for TFDP2 Gene

Aliases for TFDP2 Gene

  • Transcription Factor Dp-2 2 3 5
  • Transcription Factor Dp-2 (E2F Dimerization Partner 2) 2 3
  • E2F Dimerization Partner 2 2 4
  • DP2 3 4

External Ids for TFDP2 Gene

Previous GeneCards Identifiers for TFDP2 Gene

  • GC03M138604
  • GC03M142499
  • GC03M142951
  • GC03M142991
  • GC03M143153
  • GC03M141665
  • GC03M139036

Summaries for TFDP2 Gene

Entrez Gene Summary for TFDP2 Gene

  • The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TFDP2 Gene

TFDP2 (Transcription Factor Dp-2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot for TFDP2 Gene

  • Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for TFDP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP2 Gene

Genomics for TFDP2 Gene

Regulatory Elements for TFDP2 Gene

Enhancers for TFDP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G141795 1.3 FANTOM5 Ensembl ENCODE 1.9 +352.3 352307 4.0 TFAP4 ZNF146 SUZ12 TEAD4 MAX RBBP5 POLR2A HLF NRF1 CBFB ATP1B3 RNF7 GRK7 RASA2 TFDP2 GK5 PIR31846 LOC105374134
GH03G141974 0.4 FANTOM5 4.8 +174.9 174893 0.2 FOXA1 TFDP2 PIR46950 RPL19P6
GH03G142147 1 ENCODE 0.7 +0.9 867 2.9 HDGF FOXA2 ATF1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF207 FOS TFDP2 RNU6-425P
GH03G142222 1.1 ENCODE 0.2 -74.9 -74855 3.6 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GK5 TFDP2
GH03G142209 0.9 Ensembl ENCODE 0.2 -60.9 -60900 2.3 CTCF ZNF654 RFX1 EBF1 BMI1 RAD21 JUND POLR2A SMARCA4 SCRT2 GK5 TFDP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TFDP2 on UCSC Golden Path with GeneCards custom track

Promoters for TFDP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159420 644 2201 HDGF FOXA2 ATF1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF207 FOS

Genomic Location for TFDP2 Gene

Chromosome:
3
Start:
141,944,428 bp from pter
End:
142,149,544 bp from pter
Size:
205,117 bases
Orientation:
Minus strand

Genomic View for TFDP2 Gene

Genes around TFDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP2 Gene

Proteins for TFDP2 Gene

  • Protein details for TFDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14188-TFDP2_HUMAN
    Recommended name:
    Transcription factor Dp-2
    Protein Accession:
    Q14188
    Secondary Accessions:
    • B7Z8C8
    • B7Z8L5
    • D3DNG1
    • E9PFC3
    • F8WAI2
    • Q13331
    • Q14187
    • Q6R754
    • Q8WU88
    • Q9UG28

    Protein attributes for TFDP2 Gene

    Size:
    446 amino acids
    Molecular mass:
    49236 Da
    Quaternary structure:
    • Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. During the cell cycle, RB becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with GMCL (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP2:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity (PubMed:20176812).
    SequenceCaution:
    • Sequence=AAR89905.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB45775.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TFDP2 Gene

    Alternative splice isoforms for TFDP2 Gene

neXtProt entry for TFDP2 Gene

Post-translational modifications for TFDP2 Gene

  • Ser-24 is probably phosphorylated by CDK2.
  • Ubiquitination at Lys120, Lys178, posLast=205205, Lys224, Lys249, and isoforms=6, 7, 8, 2, 4, 5, 3328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TFDP2 Gene

Domains & Families for TFDP2 Gene

Gene Families for TFDP2 Gene

Suggested Antigen Peptide Sequences for TFDP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14188

UniProtKB/Swiss-Prot:

TFDP2_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP2: view

Function for TFDP2 Gene

Molecular function for TFDP2 Gene

GENATLAS Biochemistry:
transcription factor 2 heterodimerizing with E2F family members
UniProtKB/Swiss-Prot Function:
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Ontology (GO) - Molecular Function for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA,TAS --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7784053
GO:0003712 transcription cofactor activity IEA,TAS --
GO:0005515 protein binding IPI 16061792
genes like me logo Genes that share ontologies with TFDP2: view
genes like me logo Genes that share phenotypes with TFDP2: view

Animal Model Products

CRISPR Products

miRNA for TFDP2 Gene

miRTarBase miRNAs that target TFDP2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TFDP2 Gene

Localization for TFDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TFDP2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TFDP2: view

Pathways & Interactions for TFDP2 Gene

genes like me logo Genes that share pathways with TFDP2: view

Gene Ontology (GO) - Biological Process for TFDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with TFDP2: view

No data available for SIGNOR curated interactions for TFDP2 Gene

Transcripts for TFDP2 Gene

Unigene Clusters for TFDP2 Gene

Transcription factor Dp-2 (E2F dimerization partner 2):
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP2 Gene

No ASD Table

Relevant External Links for TFDP2 Gene

GeneLoc Exon Structure for
TFDP2
ECgene alternative splicing isoforms for
TFDP2

Expression for TFDP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TFDP2 Gene

mRNA differential expression in normal tissues according to GTEx for TFDP2 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for TFDP2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFDP2 Gene



Protein tissue co-expression partners for TFDP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TFDP2 Gene:

TFDP2

SOURCE GeneReport for Unigene cluster for TFDP2 Gene:

Hs.379018

mRNA Expression by UniProt/SwissProt for TFDP2 Gene:

Q14188-TFDP2_HUMAN
Tissue specificity: High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.

Evidence on tissue expression from TISSUES for TFDP2 Gene

  • Kidney(4.4)
  • Skin(4.2)
  • Nervous system(3.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with TFDP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFDP2 Gene

Orthologs for TFDP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TFDP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFDP2 34 35
  • 99.93 (n)
cow
(Bos Taurus)
Mammalia TFDP2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFDP2 34 35
  • 94.99 (n)
mouse
(Mus musculus)
Mammalia Tfdp2 34 16 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Tfdp2 34
  • 91.26 (n)
oppossum
(Monodelphis domestica)
Mammalia TFDP2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFDP2 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFDP2 34 35
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia TFDP2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfdp2 34
  • 69.43 (n)
Str.21 34
zebrafish
(Danio rerio)
Actinopterygii tfdp2 34 35
  • 65.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dp 36 35
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea dpl-1 36 35
  • 52 (a)
soybean
(Glycine max)
eudicotyledons Gma.17914 34
rice
(Oryza sativa)
Liliopsida Os.46788 34
corn
(Zea mays)
Liliopsida Zm.2249 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 35
  • 38 (a)
OneToMany
Species where no ortholog for TFDP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFDP2 Gene

ENSEMBL:
Gene Tree for TFDP2 (if available)
TreeFam:
Gene Tree for TFDP2 (if available)

Paralogs for TFDP2 Gene

Paralogs for TFDP2 Gene

genes like me logo Genes that share paralogs with TFDP2: view

Variants for TFDP2 Gene

Sequence variations from dbSNP and Humsavar for TFDP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000005048 -- 142,108,023(+) TATTT(C/T)TTGAG intron-variant
rs1000011291 -- 142,006,935(+) TCATG(C/T)CTGGC intron-variant
rs1000022269 -- 141,961,852(+) GGGAC(C/T)GCTTG intron-variant
rs1000056051 -- 142,013,723(+) ATTGA(A/G)TAACT intron-variant
rs1000084554 -- 142,057,476(+) ATTTG(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFDP2 Gene

Variant ID Type Subtype PubMed ID
dgv1412e212 CNV gain 25503493
dgv299n21 CNV gain 19592680
dgv4912n100 CNV gain 25217958
dgv619n27 CNV gain 19166990
dgv8625n54 CNV gain 21841781
dgv8626n54 CNV gain 21841781
esv24180 CNV loss 19812545
esv26432 CNV loss 19812545
esv2657934 CNV deletion 23128226
esv2669675 CNV deletion 23128226
esv2674102 CNV deletion 23128226
esv2751979 CNV gain 17911159
esv2759182 CNV gain 17122850
esv2763767 CNV gain 21179565
esv34483 CNV gain 17911159
esv3597992 CNV loss 21293372
esv3597995 CNV gain 21293372
esv3597996 CNV gain 21293372
esv3597997 CNV loss 21293372
esv3597998 CNV loss 21293372
nsv1008873 CNV gain 25217958
nsv1013352 CNV gain 25217958
nsv1117031 CNV deletion 24896259
nsv1120462 CNV tandem duplication 24896259
nsv474635 CNV novel sequence insertion 20440878
nsv507126 OTHER sequence alteration 20534489
nsv591915 CNV loss 21841781
nsv822270 CNV loss 20364138
nsv955361 CNV duplication 24416366
nsv963365 CNV duplication 23825009

Variation tolerance for TFDP2 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFDP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TFDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFDP2 Gene

Disorders for TFDP2 Gene

Relevant External Links for TFDP2

Genetic Association Database (GAD)
TFDP2
Human Genome Epidemiology (HuGE) Navigator
TFDP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFDP2

No disorders were found for TFDP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TFDP2 Gene

Publications for TFDP2 Gene

  1. Cloning and characterization of human DP2, a novel dimerization partner of E2F. (PMID: 7784053) Zhang Y. … Chellappan S.P. (Oncogene 1995) 2 3 4 22 64
  2. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y. … Chellappan S.P. (Genomics 1997) 2 3 22 64
  3. DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. (PMID: 8755520) Rogers K.T. … Horowitz J.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  4. Repression of transcriptional activity of C/EBPalpha by E2F- dimerization partner complexes. (PMID: 20176812) Zaragoza K. … Leutz A. (Mol. Cell. Biol. 2010) 3 4 64
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 64

Products for TFDP2 Gene

Sources for TFDP2 Gene

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