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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFDP2 Gene

protein-coding   GIFtS: 63
GCID: GC03M141665

Transcription Factor Dp-2 (E2F Dimerization Partner 2)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor Dp-2 (E2F Dimerization Partner 2)1 2
DP22 3 5
Transcription Factor Dp-22
E2F Dimerization Partner 23

External Ids:    HGNC: 117511   Entrez Gene: 70292   Ensembl: ENSG000001141267   OMIM: 6021605   UniProtKB: Q141883   

Export aliases for TFDP2 gene to outside databases

Previous GC identifers: GC03M138604 GC03M142499 GC03M142951 GC03M142991 GC03M143153 GC03M139036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFDP2 Gene:
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F
transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for TFDP2 Gene: 
TFDP2 (transcription factor Dp-2 (E2F dimerization partner 2)) is a protein-coding gene. Diseases associated with TFDP2 include mantle cell lymphoma, and b-cell chronic lymphocytic leukemia, and among its related super-pathways are Mitotic G1-G1/S phases and SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is TFDP1.

UniProtKB/Swiss-Prot: TFDP2_HUMAN, Q14188
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
apoptosis

Gene Wiki entry for TFDP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFDP2 gene promoter:
         Nkx3-1 v4   AML1a   NF-YA   E4BP4   NF-YB   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TFDP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TFDP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

TFDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M141665:  view genomic region     (about GC identifiers)

Start:
141,663,270 bp from pter      End:
141,868,386 bp from pter
Size:
205,117 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFDP2_HUMAN, Q14188 (See protein sequence)
Recommended Name: Transcription factor Dp-2  
Size: 446 amino acids; 49236 Da
Subunit: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with E2F family members. The
complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that
inhibit the E2F transactivation domain. During the cell cycle, RB becomes phosphorylated in mid-to-late G1 phase,
detaches from the DRTF1/E2F complex rendering E2F transcriptionally active. Viral oncoproteins, notably E1A,
T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with
GMCL (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5,
LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent
cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54
form a subcomplex that binds to MYBL2
Subcellular location: Nucleus
Sequence caution: Sequence=AAR89905.1; Type=Erroneous gene model prediction; Sequence=CAB45775.2; Type=Erroneous
initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TFDP2:
1CF7 (3D)    
Secondary accessions: B7Z8C8 B7Z8L5 D3DNG1 E9PFC3 F8WAI2 Q13331 Q14187 Q6R754 Q8WU88 Q9UG28
Alternative splicing: 8 isoforms:  Q14188-1   Q14188-2   Q14188-3   Q14188-4   Q14188-5   Q14188-6   Q14188-7   Q14188-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TFDP2: NX_Q14188

Explore proteomics data for TFDP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ser-24 is probably phosphorylated by CDK2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14188

  • TFDP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFDP2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001171609.1  NP_001171610.1  NP_001171611.1  NP_001171612.1  NP_001171613.1  NP_006277.1  

    ENSEMBL proteins: 
     ENSP00000420616   ENSP00000420599   ENSP00000418971   ENSP00000419036   ENSP00000418590  
     ENSP00000417585   ENSP00000417384   ENSP00000419507   ENSP00000417726   ENSP00000418122  
     ENSP00000417220   ENSP00000420456   ENSP00000473436   ENSP00000417108   ENSP00000420657  
     ENSP00000419540   ENSP00000439782   ENSP00000315668   ENSP00000309622   ENSP00000381078  
    Reactome Protein details: Q14188
    Human Recombinant Protein Products for TFDP2: 
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    Cloud-Clone Corp. Proteins for TFDP2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    TFDP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR014889 Transc_factor_DP_C
     IPR011991 WHTH_DNA-bd_dom
     IPR015648 Transcrpt_fac_DP
     IPR016556 Transcription_factor_DP_subgr

    Graphical View of Domain Structure for InterPro Entry Q14188

    ProtoNet protein and cluster: Q14188

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: TFDP2_HUMAN, Q14188
    Similarity: Belongs to the E2F/DP family


    TFDP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFDP2_HUMAN, Q14188
    Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
    E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
    involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
    cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
    apoptosis

         Genatlas biochemistry entry for TFDP2:
    transcription factor 2 heterodimerizing with E2F family members

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity TAS7784053
    GO:0008134transcription factor binding IPI16360038
    GO:0019904protein domain specific binding IPI16360038
         
    TFDP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TFDP2:
     Decreased POU5F1-GFP protein e  Decreased p24 protein expressi  Increased cell number in G1, a 

         1 MGI phenotypic allele for Tfdp2 (no phenotypes)

    TFDP2 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TFDP2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    5Cyclins and Cell Cycle Regulation
    G1 Phase0.32
    Cyclin D associated events in G10.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for TFDP2
        G1 to S cell cycle control
    TGF-beta Receptor Signaling Pathway
    E2F transcription factor network

    5/12        Reactome Pathways for TFDP2 (see all 12)
        G1 Phase
    Generic Transcription Pathway
    Mitotic G1-G1/S phases
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    G0 and Early G1


    1         Kegg Pathway  (Kegg details for TFDP2):
        Cell cycle


    TFDP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFDP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for TFDP2 (Q141882, 3 ENSP000003096224) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F6O754612, 3, ENSP000003709364MINT-68429 I2D: score=6 STRING: ENSP00000370936
    YWHAEP622582, 3, ENSP000002643354MINT-1785035 I2D: score=2 STRING: ENSP00000264335
    E2F4Q162542, 3, ENSP000003686864MINT-24872 I2D: score=6 STRING: ENSP00000368686
    E2F1Q010943, ENSP000003455714I2D: score=3 STRING: ENSP00000345571
    LIN37Q96GY33, ENSP000003011594I2D: score=2 STRING: ENSP00000301159
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    TFDP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFDP2

    Search CenterWatch for drugs/clinical trials and news about TFDP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFDP2 gene (6 alternative transcripts): 
    NM_001178138.1  NM_001178139.1  NM_001178140.1  NM_001178141.1  NM_001178142.1  NM_006286.4  

    Unigene Cluster for TFDP2:

    Transcription factor Dp-2 (E2F dimerization partner 2)
    Hs.379018  [show with all ESTs]
    Unigene Representative Sequence: NM_001178138
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000489671 ENST00000486111 ENST00000477292 ENST00000495310 ENST00000467072
    ENST00000479040 ENST00000487734 ENST00000474279 ENST00000467667 ENST00000478006
    ENST00000497579 ENST00000492919 ENST00000493204 ENST00000464782 ENST00000488107
    ENST00000494656 ENST00000475734 ENST00000471095
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK096450.1 AK303181.1 AK303634.1 AK314786.1 AL080206.1 BC007976.2 BC013993.2 BC021113.1 
    BC040991.2 BX647881.1 L40386.1 U18422.1 U35117.1 

    22 DOTS entries:

    DT.97843718  DT.100747333  DT.445961  DT.315714  DT.95350109  DT.120880447  DT.95350115  DT.439288 
    DT.100863395  DT.65286459  DT.95330567  DT.120880410  DT.97770826  DT.102830557  DT.120880380  DT.120880435 
    DT.120880437  DT.40191079  DT.75180223  DT.86841219  DT.95350119  DT.101957404 

    24/191 AceView cDNA sequences (see all 191):

    CD366173 CR597951 AI362850 BM467379 BC013993 BU192065 BM456393 BM999796 
    H78843 AI217927 N54408 BE162216 AW590207 CR613689 AA287636 CR592926 
    BM794120 AA447792 U35117 BM931318 BQ774025 AA687302 BM560485 AW675827 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFDP2 expression in normal human tissues (normalized intensities)      TFDP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGACATAGA
    TFDP2 Expression
    About this image


    TFDP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See TFDP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFDP2

    SOURCE GeneReport for Unigene cluster: Hs.379018

    UniProtKB/Swiss-Prot: TFDP2_HUMAN, Q14188
    Tissue specificity: High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and
    liver. The presence as well as the abundance of the different transcripts appear to vary significantly in
    different tissues and cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including TFDP2: 
              Cell Cycle in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TFDP2 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfdp21 , 5 transcription factor Dp 21, 5 91.95(n)1
    95.58(a)1
      9 (50.31 cM)5
    2115861  NM_001184711.11  NP_001171640.11 
     961962755 
    chicken
    (Gallus gallus)
    Aves TFDP21 transcription factor Dp-2 (E2F dimerization partner more 80.18(n)
    84.91(a)
      424780  NM_001184713.1  NP_001171642.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFDP26
    Uncharacterized protein
    78(a)
    1 ↔ 1
    3(21986097-22037251)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.212 Transcribed sequence with moderate similarity to protein more 76.46(n)    AL965517.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tfdp21 transcription factor Dp-2 65.22(n)
    67.6(a)
      338204  NM_198208.1  NP_937851.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dp3 dorsal/ventral axis determination,
    follicular more
    58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dpl-13 transcription factor DP-1 52(a)   II(9169866-9172120)   --
    soybean
    (Glycine max)
    eudicotyledons Gma.179142 Transcribed sequence with moderate similarity to protein more 73.75(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.467882 Oryza sativa (japonica cultivar-group) isolate 26539 more 76.86(n)    AY224551.1 


    ENSEMBL Gene Tree for TFDP2 (if available)
    TreeFam Gene Tree for TFDP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFDP2 gene
    TFDP12  TFDP32  
    2 SIMAP similar genes for TFDP2 using alignment to 12 protein entries:     TFDP2_HUMAN (see all proteins):
    TFDP1    TFDP3

    TFDP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4171 SNPs in TFDP2 are shown (see all 4171)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0022724
    ----see VAR_0022722 I T mis40--------
    rs1413458571,2
    --141662914(+) AAAACA/TAAAAA 6 -- ds50010--------
    rs1428954431,2
    C--141662925(+) AAGGC-/TTTTTT 6 -- ds50010--------
    rs1493424281,2
    --141662941(+) TTTTT-/GAGATG 6 -- ds50010--------
    rs1816456211,2
    --141663318(+) AATCAG/TAAAAG 6 -- ut310--------
    rs154091,2
    F--141663449(+) AAATAC/AAGCTT 6 -- ut312Minor allele frequency- A:0.09MN 368
    rs1469984421,2
    C--141663509(+) AGGATC/TGCAAA 6 -- ut310--------
    rs1862188721,2
    --141663542(+) CTCCAA/CGGCAG 6 -- ut310--------
    rs580621381,2
    C--141663570(+) CTTAGC/TGGAAC 6 -- ut311Minor allele frequency- T:0.50WA 2
    rs10452791,2
    C,F,A,H--141663683(-) TAAATA/GCCATT 6 -- ut3114Minor allele frequency- G:0.10MN NA WA CSA EA 563

    HapMap Linkage Disequilibrium report for TFDP2 (141663270 - 141868386 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TFDP2 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657934CNV Deletion23128226
    esv2669675CNV Deletion23128226
    esv2674102CNV Deletion23128226
    nsv507126CNV Insertion20534489
    dgv5265n71CNV Loss21882294
    esv26432CNV Loss19812545
    nsv822270CNV Loss20364138
    esv24180CNV Loss19812545
    dgv299n21CNV Gain19592680
    esv34483CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602160    OMIM disorders: --

    8 diseases for TFDP2:    About MalaCards
    mantle cell lymphoma    b-cell chronic lymphocytic leukemia    retinoblastoma    kidney disease
    chronic lymphocytic leukemia    ovarian cancer    hepatocellular carcinoma    leukemia


    TFDP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TFDP2
    Human Genome Epidemiology (HuGE) Navigator: TFDP2 (3 documents)

    Export disorders for TFDP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFDP2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TFDP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human DP2, a novel dimerization partner of E2F. (PubMed id 7784053)1, 2, 3, 9 Zhang Y. and Chellappan S.P. (1995)
    2. DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. (PubMed id 8755520)1, 2, 9 Rogers K.T.... Horowitz J.M. (1996)
    3. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PubMed id 9027491)1, 3, 9 Zhang Y....Chellappan S.P. (1997)
    4. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
    5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    6. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
    7. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. (PubMed id 16360038)1, 2 Rubin S.M....Pavletich N.P. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. (PubMed id 10090723)1, 2 Zheng N.... Pavletich N.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7029 HGNC: 11751 AceView: TFDP2 Ensembl:ENSG00000114126 euGenes: HUgn7029
    ECgene: TFDP2 Kegg: 7029 H-InvDB: TFDP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFDP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFDP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tfdp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFDP2 gene:
    Search GeneIP for patents involving TFDP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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