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Aliases for TFDP1 Gene

Aliases for TFDP1 Gene

  • Transcription Factor Dp-1 2 3
  • DRTF1 3 4 6
  • DP1 3 4 6
  • E2F Dimerization Partner 1 3 4
  • DRTF1-Polypeptide 1 3 4
  • E2F-Related Transcription Factor 3
  • Dp-1 3

External Ids for TFDP1 Gene

Summaries for TFDP1 Gene

Entrez Gene Summary for TFDP1 Gene

  • This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

GeneCards Summary for TFDP1 Gene

TFDP1 (Transcription Factor Dp-1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot for TFDP1 Gene

  • Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for TFDP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP1 Gene

Genomics for TFDP1 Gene

Genomic Location for TFDP1 Gene

Start:
113,584,688 bp from pter
End:
113,641,473 bp from pter
Size:
56,786 bases
Orientation:
Plus strand

Genomic View for TFDP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP1 Gene

Regulatory Elements for TFDP1 Gene

Proteins for TFDP1 Gene

  • Protein details for TFDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14186-TFDP1_HUMAN
    Recommended name:
    Transcription factor Dp-1
    Protein Accession:
    Q14186
    Secondary Accessions:
    • B4DLQ9
    • Q5JSB4
    • Q8IZL5

    Protein attributes for TFDP1 Gene

    Size:
    410 amino acids
    Molecular mass:
    45070 Da
    Quaternary structure:
    • Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812).
    Miscellaneous:
    • E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP

    Three dimensional structures from OCA and Proteopedia for TFDP1 Gene

    Alternative splice isoforms for TFDP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFDP1 Gene

Proteomics data for TFDP1 Gene at MOPED

Post-translational modifications for TFDP1 Gene

  • Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys190, Lys234, and Lys320

Other Protein References for TFDP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TFDP1 Gene

Domains for TFDP1 Gene

UniProtKB/Swiss-Prot:

TFDP1_HUMAN
Family:
  • Belongs to the E2F/DP family.:
    • Q14186
genes like me logo Genes that share domains with TFDP1: view

No data available for Gene Families for TFDP1 Gene

Function for TFDP1 Gene

Molecular function for TFDP1 Gene

GENATLAS Biochemistry: transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in esophageal squamous cell carcinoma
UniProtKB/Swiss-Prot Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
UniProtKB/Swiss-Prot Induction: Down-regulated during differentiation

Gene Ontology (GO) - Molecular Function for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8405995
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TFDP1: view
genes like me logo Genes that share phenotypes with TFDP1: view

Animal Models for TFDP1 Gene

MGI Knock Outs for TFDP1:

miRNA for TFDP1 Gene

miRTarBase miRNAs that target TFDP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TFDP1 Gene

Localization for TFDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFDP1 Gene COMPARTMENTS Subcellular localization image for TFDP1 gene
Compartment Confidence
nucleus 5
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TFDP1: view

Pathways for TFDP1 Gene

SuperPathways for TFDP1 Gene

genes like me logo Genes that share pathways with TFDP1: view

Gene Ontology (GO) - Biological Process for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8405995
genes like me logo Genes that share ontologies with TFDP1: view

Compounds for TFDP1 Gene

(1) Novoseek inferred chemical compound relationships for TFDP1 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 0 1
genes like me logo Genes that share compounds with TFDP1: view

Transcripts for TFDP1 Gene

Unigene Clusters for TFDP1 Gene

Transcription factor Dp-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - -
SP7: - -
SP8: - - -
SP9: - - - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TFDP1 Gene

GeneLoc Exon Structure for
TFDP1
ECgene alternative splicing isoforms for
TFDP1

Expression for TFDP1 Gene

mRNA expression in normal human tissues for TFDP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFDP1 Gene

SOURCE GeneReport for Unigene cluster for TFDP1 Gene Hs.79353

mRNA Expression by UniProt/SwissProt for TFDP1 Gene

Q14186-TFDP1_HUMAN
Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart
genes like me logo Genes that share expressions with TFDP1: view

Orthologs for TFDP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFDP1 36
  • 99.67 (n)
  • 100 (a)
TFDP1 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFDP1 36
  • 85.79 (n)
  • 93.4 (a)
TFDP1 37
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 93 (a)
OneToMany
TFDP1 36
  • 88.55 (n)
  • 95.64 (a)
mouse
(Mus musculus)
Mammalia Tfdp1 36
  • 87.48 (n)
  • 95.43 (a)
Tfdp1 16
Tfdp1 37
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia MGC112830 36
  • 86.98 (n)
  • 95.99 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 90 (a)
OneToMany
TFDP1 36
  • 80.88 (n)
  • 91.12 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.33142 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tfdp1 36
  • 77.07 (n)
  • 88.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10859 36
zebrafish
(Danio rerio)
Actinopterygii tfdp1a 36
  • 72.79 (n)
  • 81.12 (a)
tfdp1a 37
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dp 37
  • 36 (a)
OneToMany
Dp 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea dpl-1 37
  • 23 (a)
OneToMany
dpl-1 38
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4637 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 37
  • 38 (a)
OneToMany
Species with no ortholog for TFDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFDP1 Gene

ENSEMBL:
Gene Tree for TFDP1 (if available)
TreeFam:
Gene Tree for TFDP1 (if available)

Paralogs for TFDP1 Gene

Paralogs for TFDP1 Gene

Selected SIMAP similar genes for TFDP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TFDP1 Gene

genes like me logo Genes that share paralogs with TFDP1: view

Variants for TFDP1 Gene

Sequence variations from dbSNP and Humsavar for TFDP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1806586 -- 113,594,494(-) CACCA(C/T)ACCTG intron-variant
rs2001275 -- 113,607,493(-) CAAGC(A/G)TGGCA intron-variant
rs2316118 -- 113,622,886(-) GACCA(C/T)GGCCT intron-variant
rs2316119 -- 113,604,946(-) GCTGC(C/T)CACCT intron-variant
rs2316120 -- 113,604,022(-) ATGCC(C/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFDP1 Gene

Variant ID Type Subtype PubMed ID
nsv901074 CNV Loss 21882294
nsv832726 CNV Loss 17160897
nsv901075 CNV Loss 21882294
nsv509523 CNV Insertion 20534489
esv2748339 CNV Deletion 23290073
esv2748340 CNV Deletion 23290073
esv2748342 CNV Deletion 23290073
esv2748343 CNV Deletion 23290073
esv2748344 CNV Deletion 23290073
esv2748345 CNV Deletion 23290073
esv2748346 CNV Deletion 23290073
esv2748347 CNV Deletion 23290073
esv2748348 CNV Deletion 23290073
esv23154 CNV Loss 19812545
nsv820428 CNV Duplication 20802225
esv2664676 CNV Deletion 23128226

Relevant External Links for TFDP1 Gene

HapMap Linkage Disequilibrium report
TFDP1
Human Gene Mutation Database (HGMD)
TFDP1

Disorders for TFDP1 Gene

(6) Novoseek inferred disease relationships for TFDP1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 77.9 6
tumors 27.5 5
colon carcinoma 21.3 1
breast carcinoma 7.31 3
hepatocellular carcinoma 0 2

Relevant External Links for TFDP1

Genetic Association Database (GAD)
TFDP1
Human Genome Epidemiology (HuGE) Navigator
TFDP1
genes like me logo Genes that share disorders with TFDP1: view

No data available for UniProtKB/Swiss-Prot for TFDP1 Gene

Publications for TFDP1 Gene

  1. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PMID: 8405995) Helin K. … Harlow E. (Genes Dev. 1993) 3 4 23
  2. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y. … Chellappan S.P. (Genomics 1997) 2 3 23
  3. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PMID: 8039504) Bandara L.R. … la Thangue N.B. (EMBO J. 1994) 3 4 23
  4. Functional interaction between DP-1 and p53. (PMID: 8816502) SA … La Thangue N.B. (Mol. Cell. Biol. 1996) 3 23
  5. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. (PMID: 8832394) Magae J. … Heintz N.H. (J. Cell. Sci. 1996) 3 23

Products for TFDP1 Gene

  • Addgene plasmids for TFDP1

Sources for TFDP1 Gene

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