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TFDP1 Gene

protein-coding GIFtS: 67
GCID: GC13P114239

Transcription Factor Dp-1

Microbiology & Infectious Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Transcription Factor Dp-1¹ ²		E2F Dimerization Partner 1² ³
DP1² ³ ⁵		Dp-1²
DRTF1² ³ ⁵		E2F-Related Transcription Factor²
DRTF1-Polypeptide 1² ³

External Ids:	HGNC: 11749¹	Entrez Gene: 7027²	Ensembl: ENSG00000198176⁷	OMIM: 189902⁵	UniProtKB: Q14186³

Export aliases for TFDP1 gene to outside databases

Previous GC identifers: GC13P112848 GC13P108876 GC13P113325 GC13P112187 GC13P113287 GC13P094679

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFDP1 Gene:

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance

their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part

of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from

G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found

on chromosomes 1, 15, and X.(provided by RefSeq, Jan 2009)

GeneCards Summary for TFDP1 Gene:

TFDP1 (transcription factor Dp-1) is a protein-coding gene. Diseases associated with TFDP1 include differentiating neuroblastoma, and retinoblastoma. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the

E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are

involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of

cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and

apoptosis

Gene Wiki entry for TFDP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000013.11 NT_027140.7 NC_018924.2

Regulatory elements:

Regulatory transcription factor binding sites in the TFDP1 gene promoter:
POU2F1 POU2F1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for TFDP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFDP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

TFDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P114239: view genomic region (about GC identifiers)

Start:	114,239,003 bp from pter	End:	114,295,788 bp from pter
Size:	56,786 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186 (See protein sequence)

Recommended Name: Transcription factor Dp-1

Size: 410 amino acids; 45070 Da

Subunit: Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The

complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that

inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC).

During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the

DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7,

are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0

phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of

the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1,

MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell

cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds

to MYBL2

Miscellaneous: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP

1 PDB 3D structure from and Proteopedia for TFDP1:

2AZE (3D)

Secondary accessions: Q5JSB4 Q8IZL5

Explore the universe of human proteins at neXtProt for TFDP1: NX_Q14186

Explore proteomics data for TFDP1 at MOPED

Post-translational modifications:

Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation¹

Ubiquitination² at Lys44, Lys190, Lys234, Lys320

Modification sites at PhosphoSitePlus

See TFDP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009042.1

ENSEMBL proteins:

ENSP00000364519 ENSP00000386145 ENSP00000401389 ENSP00000443878 ENSP00000438450

Reactome Protein details: Q14186

TFDP1 Human Recombinant Protein Products:

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TFDP1 Assay Products:

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	Cloud-Clone Corp. ELISAs for TFDP1 Cloud-Clone Corp. CLIAs for TFDP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR003316 E2F_TDP

IPR014889 Transc_factor_DP_C

IPR011991 WHTH_DNA-bd_dom

IPR015648 Transcrpt_fac_DP

IPR028313 DP-1

Graphical View of Domain Structure for InterPro Entry Q14186

ProtoNet protein and cluster: Q14186

1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186

Similarity: Belongs to the E2F/DP family

TFDP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TFDP1_HUMAN, Q14186

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the

E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are

involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of

cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and

apoptosis

Induction: Down-regulated during differentiation

Genatlas biochemistry entry for TFDP1:

transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in

esophageal squamous cell carcinoma

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003713	transcription coactivator activity	IEA	--
GO:0005515	protein binding	IPI	16360038
GO:0008134	transcription factor binding	IPI	16360038

TFDP1 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for TFDP1:

Decreased viability of wild-ty

G0/1 arrest

Increased G1 DNA content

Increased cell number in S

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tfdp1):

embryogenesis

growth/size/body

mortality/aging

nervous system

tumorigenesis

TFDP1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Tfdp1^tm1Lili for TFDP1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFDP1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFDP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFDP1

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		Selected qRT-PCR Assays for microRNAs that regulate TFDP1 (see all 21):
		hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: TFDP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TFDP1
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Gene Editing
Products:

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		Sino Biological Human cDNA Clone for TFDP1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TFDP1_HUMAN, Q14186: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
lysosome	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--

TFDP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TFDP1 About (see all 27)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

E2F mediated regulation of DNA replication

Mitotic G1-G1/S phases	0.81	E2F mediated regulation of DNA replication	0.30
G1/S Transition	0.81	G1/S-Specific Transcription	0.00
G1 to S cell cycle control	0.35	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.00

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	0.67			G1 Phase	0.31
	G1-S Phase Transition	0.67			Cyclin D associated events in G1	0.31

Cell cycle

Cell cycle

0.59

Cell cycle

0.59

Loss of Function of SMAD2/3 in Cancer

Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer	0.72	Signaling by TGF-beta Receptor Complex	0.60
SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription	0.72	TGFBR1 KD Mutants in Cancer	0.60
Loss of Function of SMAD2/3 in Cancer	0.60	SMAD2/3 MH2 Domain Mutants in Cancer	0.60
Loss of Function of SMAD4 in Cancer	0.60	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.60

Activation of BH3-only proteins

	Activation of BH3-only proteins	0.68			Activation of NOXA and translocation to mitochondria	0.00
	Intrinsic Pathway for Apoptosis	0.68			Activation of PUMA and translocation to mitochondria	0.00

Pathways by source See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TFDP1

	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry
	Cyclins and Cell Cycle Regulation
	MNAR-PELP1 and Estrogen Receptor Interaction

5 GeneGo (Thomson Reuters) Pathways for TFDP1

	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle ESR1 regulation of G1/S transition
	Cell cycle Transition and termination of DNA replication
	Cell cycle Cell cycle (generic schema)
	Cell cycle Start of DNA replication in early S phase

Selected BioSystems Pathways for TFDP1 (see all 8)

	Cell cycle
	G1 to S cell cycle control
	TGF-beta Receptor Signaling Pathway
	RB in Cancer
	E2F transcription factor network

Selected Reactome Pathways for TFDP1 (see all 11)

	G0 and Early G1
	Inhibition of replication initiation of damaged DNA by RB1/E2F1
	Oncogene Induced Senescence
	Activation of NOXA and translocation to mitochondria
	Activation of PUMA and translocation to mitochondria

2 Kegg Pathways (Kegg details for TFDP1):

	Cell cycle
	TGF-beta signaling pathway

TFDP1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including TFDP1:

Cell Cycle in human mouse rat

Interactions:

GeneGlobe Interaction Network for TFDP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TFDP1 (Q14186^{1, 2, 3} ENSP00000364519⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 188)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
E2F1	Q01094¹^,²^,³, ENSP00000345571⁴	EBI-749713,EBI-448924 MINT-8381834 MINT-8381854 I2D: score=4 STRING: ENSP00000345571
DVL1	O14640¹^,²	EBI-749713,EBI-723489 MINT-8404114 MINT-8404100 MINT-8404082
NLK	Q9UBE8¹^,²	EBI-749713,EBI-366978 MINT-8403941 MINT-8403953
BAG6	P46379³	I2D: score=3
ENSG00000096155	P46379³	I2D: score=3

About this table

Gene Ontology (GO): Selected biological process terms (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006351	transcription, DNA-templated	TAS	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	8405995

TFDP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TFDP1

1 Novoseek inferred chemical compound relationship for TFDP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	0	2	12029633 (1)

TFDP1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TFDP1 gene:

NM_007111.4

Unigene Cluster for TFDP1:

Transcription factor Dp-1

Hs.79353 [show with all ESTs]

Unigene Representative Sequence: NM_007111

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000475254 ENST00000464794(uc001vtv.3) ENST00000375370(uc010tkd.2 uc001vtw.3 uc010tke.2 uc001vty.4)

ENST00000465174 ENST00000408980(uc010agx.3) ENST00000453989 ENST00000494812

ENST00000538138 ENST00000544902

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat TFDP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TFDP1 (see all 21):
		hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: TFDP1 3' UTR sequence

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Primer Products:		OriGene qPCR primer pairs and template standards for TFDP1 OriGene qSTAR qPCR primer pairs in human, mouse for TFDP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TFDP1
		QuantiTect SYBR Green Assays in human, mouse, rat TFDP1
		QuantiFast Probe-based Assays in human, mouse, rat TFDP1

Additional mRNA sequence:

AK297114.1 AK298521.1 AK310401.1 AK313742.1 BC011685.2 BC036601.1 L23959.1 NR_026580.1

21 DOTS entries:

DT.218350 DT.101964181 DT.405179 DT.100824113 DT.95203246 DT.100835726 DT.40247167 DT.92445730

DT.100824123 DT.120764051 DT.86857687 DT.95336151 DT.100824114 DT.100824115 DT.100824125 DT.95127613

DT.95134804 DT.100824120 DT.121350111 DT.91811411 DT.95111609

Selected AceView cDNA sequences (see all 401):

BQ933494 CR614715 AW005416 N70946 AA642409 BQ436190 BM718399 CB852660

BE269676 CD364530 AV724328 AI468403 BU187839 BM683456 BM766221 AI360268

BF224431 F04606 BQ025624 BQ945665 BQ718346 BQ021225 BQ446215 CR616214

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	·
SP1:																	-																								-
SP2:																																									-		-		-
SP3:									-		-						-
SP4:																	-
SP5:																																									-				-

ExUns:	16d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TFDP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TFDP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGCATTTTAA

About this image

TFDP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Thymus (Hematopoietic System)
Double Negative 2 Thymocytes Thymus

Gonad (Reproductive System)
Primordial Germ Cells Primitive Gonad

Blood (Cardiovascular System)
Double Negative 2 Thymocytes Thymus

Ovary (Reproductive System)

Testis (Reproductive System)

TFDP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TFDP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.79353

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186

Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in

lung and pancreas. Not detected in heart

Pathway & Disease-focused RT² Profiler PCR Array including TFDP1:

Cell Cycle in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TFDP1 OriGene qSTAR qPCR primer pairs in human, mouse for TFDP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TFDP1
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		QuantiFast Probe-based Assays in human, mouse, rat TFDP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TFDP1 gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tfdp1^{1 , 5}	transcription factor Dp 1^{1, 5}	87.48(n)¹ 95.43(a)¹		8 (5.78 cM)⁵ 21781¹ NM_009361.2¹ NP_033387.1¹ 13339674⁵
chicken (Gallus gallus)	Aves	TFDP1¹	transcription factor Dp-1	80.88(n) 91.12(a)		418739 XM_004938529.1 XP_004938586.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	90(a)	1 → many	3(106250490-106306788)
African clawed frog (Xenopus laevis)	Amphibia	Xl.33142²	Xenopus laevis transcribed sequence with moderate similarity more	77.57(n)		CA793927.1
zebrafish (Danio rerio)	Actinopterygii	BC044409.1²	--	76.81(n)		BC044409.1
fruit fly (Drosophila melanogaster)	Insecta	Dp³	dorsal/ventral axis determination, follicular more	58(a)		--
worm (Caenorhabditis elegans)	Secernentea	dpl-1³	transcription factor DP-1	52(a)		II(9169866-9172120) --

ENSEMBL Gene Tree for TFDP1 (if available)
TreeFam Gene Tree for TFDP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TFDP1 gene

TFDP3² TFDP2²

2 SIMAP similar genes for TFDP1 using alignment to 5 protein entries: TFDP1_HUMAN (see all proteins):

TFDP2 TFDP3

TFDP1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TFDP1
PGOHUM00000246873 PGOHUM00000245193 PGOHUM00000232901

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141348121^1,2		--	95172473(+)	`AAGAAA/GCGGGT`	2	--	us2k¹		0	--	--	--	--
rs7324599^1,2	C,F,A	--	95172527(+)	`GGGTGC/TGGCGT`	2	--	us2k¹		6		NA WA CSA EA	245
rs7323179^1,2	C,F,A	--	95172531(+)	`GCGGCG/CTTGCC`	2	--	us2k¹		6		NA WA CSA EA	245
rs184426065^1,2		--	95172543(+)	`GAGGGA/GCAGGA`	2	--	us2k¹		0	--	--	--	--
rs143100353^1,2		--	95172618(+)	`AGAGGC/TCTTTG`	2	--	us2k¹		0	--	--	--	--
rs36204084^1,2	C	--	95172635(+)	`TCCTCA/GAGTCC`	2	--	us2k¹		0	--	--	--	--
rs141162925^1,2		--	95172665(+)	`CTCGGA/CGCGCA`	2	--	us2k¹		0	--	--	--	--
rs190395109^1,2		--	95172728(+)	`GCCCGC/TCCTTG`	2	--	us2k¹		0	--	--	--	--
rs36204085^1,2	C,F	--	95172759(+)	`CCCTAG/ACGGCG`	2	--	us2k¹		2		WA	120
rs182566491^1,2	C	--	95172760(+)	`CCTAGC/GGGCGG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TFDP1 (114239003 - 114295788 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TFDP1 (see all 16): About this table

Variant ID	Type	Subtype	PubMed ID
esv2748347	CNV	Deletion	23290073
esv2748340	CNV	Deletion	23290073
esv2748344	CNV	Deletion	23290073
esv2748342	CNV	Deletion	23290073
esv2748348	CNV	Deletion	23290073
esv2748345	CNV	Deletion	23290073
esv2748339	CNV	Deletion	23290073
esv2748343	CNV	Deletion	23290073
esv2748346	CNV	Deletion	23290073
esv2664676	CNV	Deletion	23128226

Site Specific Mutation Identification with PCR Assays

2 Copy Number PCR Panels containing TFDP1:

Breast Cancer

Lung Cancer

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 189902 OMIM disorders: --

15 diseases for TFDP1:
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differentiating neuroblastoma retinoblastoma cytomegalovirus infection familial adenomatous polyposis

neuroblastoma lung adenocarcinoma esophageal squamous cell carcinoma non-hodgkin lymphoma

hodgkin's lymphoma hepatocellular carcinoma squamous cell carcinoma esophagitis

ovarian cancer adenocarcinoma breast cancer

TFDP1 for disorders About GeneDecksing

6 Novoseek inferred disease relationships for TFDP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	77.9	6	1297652 (1), 8964493 (1), 7784053 (1), 9322885 (1) (see all 6)
tumors	27.5	5	17483321 (1), 12878869 (1), 7809128 (1), 9322885 (1) (see all 5)
colon carcinoma	21.3	1	11052627 (1)
breast carcinoma	7.31	3	17483321 (2), 11052627 (1)
hepatocellular carcinoma	0	2	12029633 (1), 14618416 (1)
carcinoma	0	1	14618416 (1)

Genetic Association Database (GAD): TFDP1
Human Genome Epidemiology (HuGE) Navigator: TFDP1 (2 documents)

Export disorders for TFDP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TFDP1 gene, integrated from 10 sources (see all 112):
(articles sorted by number of sources associating them with TFDP1)

Utopia: connect your pdf to the dynamic
world of online information

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PubMed id 8405995)^{1, 2, 9} Helin K....Harlow E. (Genes Dev. 1993)
DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PubMed id 8039504)^{1, 2, 9} Bandara L.R....la Thangue N.B. (EMBO J. 1994)
Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PubMed id 9027491)^{1, 3, 9} Zhang Y....Chellappan S.P. (Genomics 1997)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)^{1, 4} Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)^{1, 2} Litovchick L.... DeCaprio J.A. (Mol. Cell 2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)^{1, 2} Ogawa H.... Nakatani Y. (Science 2002)
In vivo association of E2F and DP family proteins. (PubMed id 7739537)^{1, 2} Wu C.-L.... Lees J.A. (Mol. Cell. Biol. 1995)
A new component of the transcription factor DRTF1/E2F. (PubMed id 8413592)^{1, 3} Girling R....La Thangue N.B. (Nature 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7027	HGNC: 11749	AceView: TFDP1	Ensembl:ENSG00000198176	euGenes: HUgn7027
ECgene: TFDP1	Kegg: 7027	H-InvDB: TFDP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TFDP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TFDP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tfdp1/

Intellectual Property for TFDP1 gene
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Patent Information for TFDP1 gene:
Search GeneIP for patents involving TFDP1

GeneCards and IP:
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