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Aliases for TFDP1 Gene

Aliases for TFDP1 Gene

  • Transcription Factor Dp-1 2 3 5
  • Down-Regulated In Liver Cancer Stem Cells 2 3
  • E2F Dimerization Partner 1 3 4
  • DRTF1-Polypeptide 1 3 4
  • DRTF1 3 4
  • DP1 3 4
  • E2F-Related Transcription Factor 3
  • DILC 3
  • Dp-1 3

External Ids for TFDP1 Gene

Previous GeneCards Identifiers for TFDP1 Gene

  • GC13P112848
  • GC13P108876
  • GC13P113325
  • GC13P112187
  • GC13P113287
  • GC13P114239
  • GC13P094679

Summaries for TFDP1 Gene

Entrez Gene Summary for TFDP1 Gene

  • This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

GeneCards Summary for TFDP1 Gene

TFDP1 (Transcription Factor Dp-1) is a Protein Coding gene. Diseases associated with TFDP1 include Retinoblastoma. Among its related pathways are RB in Cancer and Mitotic G1-G1/S phases. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot for TFDP1 Gene

  • Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Wiki entry for TFDP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP1 Gene

Genomics for TFDP1 Gene

Regulatory Elements for TFDP1 Gene

Enhancers for TFDP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TFDP1 on UCSC Golden Path with GeneCards custom track

Promoters for TFDP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TFDP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TFDP1 Gene

Chromosome:
13
Start:
113,584,688 bp from pter
End:
113,641,473 bp from pter
Size:
56,786 bases
Orientation:
Plus strand

Genomic View for TFDP1 Gene

Genes around TFDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFDP1 Gene

Proteins for TFDP1 Gene

  • Protein details for TFDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14186-TFDP1_HUMAN
    Recommended name:
    Transcription factor Dp-1
    Protein Accession:
    Q14186
    Secondary Accessions:
    • B4DLQ9
    • Q5JSB4
    • Q8IZL5

    Protein attributes for TFDP1 Gene

    Size:
    410 amino acids
    Molecular mass:
    45070 Da
    Quaternary structure:
    • Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812).
    Miscellaneous:
    • E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.

    Three dimensional structures from OCA and Proteopedia for TFDP1 Gene

    Alternative splice isoforms for TFDP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFDP1 Gene

Proteomics data for TFDP1 Gene at MOPED

Post-translational modifications for TFDP1 Gene

  • Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
  • Ubiquitination at Lys 44, Lys 190, Lys 234, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for TFDP1 Gene

No data available for DME Specific Peptides for TFDP1 Gene

Domains & Families for TFDP1 Gene

Gene Families for TFDP1 Gene

Suggested Antigen Peptide Sequences for TFDP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14186

UniProtKB/Swiss-Prot:

TFDP1_HUMAN :
  • Belongs to the E2F/DP family.
Family:
  • Belongs to the E2F/DP family.
genes like me logo Genes that share domains with TFDP1: view

Function for TFDP1 Gene

Molecular function for TFDP1 Gene

GENATLAS Biochemistry:
transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in esophageal squamous cell carcinoma
UniProtKB/Swiss-Prot Function:
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
UniProtKB/Swiss-Prot Induction:
Down-regulated during differentiation.

Gene Ontology (GO) - Molecular Function for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with TFDP1: view
genes like me logo Genes that share phenotypes with TFDP1: view

Animal Models for TFDP1 Gene

MGI Knock Outs for TFDP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFDP1 Gene

Localization for TFDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFDP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFDP1 Gene COMPARTMENTS Subcellular localization image for TFDP1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TFDP1: view

Pathways & Interactions for TFDP1 Gene

genes like me logo Genes that share pathways with TFDP1: view

Gene Ontology (GO) - Biological Process for TFDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8405995
GO:0006915 apoptotic process TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TFDP1: view

No data available for SIGNOR curated interactions for TFDP1 Gene

Drugs & Compounds for TFDP1 Gene

(1) Additional Compounds for TFDP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TFDP1: view

Transcripts for TFDP1 Gene

Unigene Clusters for TFDP1 Gene

Transcription factor Dp-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - -
SP7: - -
SP8: - - -
SP9: - - - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TFDP1 Gene

GeneLoc Exon Structure for
TFDP1
ECgene alternative splicing isoforms for
TFDP1

Expression for TFDP1 Gene

mRNA expression in normal human tissues for TFDP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TFDP1 Gene

This gene is overexpressed in Testis (36.2), Fetal heart (13.5), and Fetal Liver (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFDP1 Gene



SOURCE GeneReport for Unigene cluster for TFDP1 Gene Hs.79353

mRNA Expression by UniProt/SwissProt for TFDP1 Gene

Q14186-TFDP1_HUMAN
Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
genes like me logo Genes that share expression patterns with TFDP1: view

Protein tissue co-expression partners for TFDP1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TFDP1 Gene

Orthologs for TFDP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFDP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TFDP1 35
  • 85.79 (n)
  • 93.4 (a)
TFDP1 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TFDP1 35
  • 88.55 (n)
  • 95.64 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tfdp1 35
  • 87.48 (n)
  • 95.43 (a)
Tfdp1 16
Tfdp1 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TFDP1 35
  • 99.67 (n)
  • 100 (a)
TFDP1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia MGC112830 35
  • 86.98 (n)
  • 95.99 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves TFDP1 35
  • 80.88 (n)
  • 91.12 (a)
-- 36
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tfdp1 35
  • 77.07 (n)
  • 88.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33142 35
zebrafish
(Danio rerio)
Actinopterygii tfdp1a 35
  • 72.79 (n)
  • 81.12 (a)
tfdp1a 36
  • 80 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10859 35
fruit fly
(Drosophila melanogaster)
Insecta Dp 37
  • 58 (a)
Dp 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpl-1 37
  • 52 (a)
dpl-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4637 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4055 36
  • 38 (a)
OneToMany
Species with no ortholog for TFDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFDP1 Gene

ENSEMBL:
Gene Tree for TFDP1 (if available)
TreeFam:
Gene Tree for TFDP1 (if available)

Paralogs for TFDP1 Gene

Paralogs for TFDP1 Gene

(2) SIMAP similar genes for TFDP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TFDP1 Gene

genes like me logo Genes that share paralogs with TFDP1: view

Variants for TFDP1 Gene

Sequence variations from dbSNP and Humsavar for TFDP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs4150823 - 113,640,235(+) AGGAC(A/G)ATGAC nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1050670 -- 113,640,359(+) GCCTA(C/G)TCCCA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1806586 -- 113,594,494(-) CACCA(C/T)ACCTG intron-variant
rs2001275 -- 113,607,493(-) CAAGC(A/G)TGGCA intron-variant
rs2316118 -- 113,622,886(-) GACCA(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFDP1 Gene

Variant ID Type Subtype PubMed ID
nsv901074 CNV Loss 21882294
nsv832726 CNV Loss 17160897
nsv901075 CNV Loss 21882294
nsv509523 CNV Insertion 20534489
esv2748339 CNV Deletion 23290073
esv2748340 CNV Deletion 23290073
esv2748342 CNV Deletion 23290073
esv2748343 CNV Deletion 23290073
esv2748344 CNV Deletion 23290073
esv2748345 CNV Deletion 23290073
esv2748346 CNV Deletion 23290073
esv2748347 CNV Deletion 23290073
esv2748348 CNV Deletion 23290073
esv23154 CNV Loss 19812545
nsv820428 CNV Duplication 20802225
esv2664676 CNV Deletion 23128226

Variation tolerance for TFDP1 Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFDP1 Gene

Human Gene Mutation Database (HGMD)
TFDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFDP1 Gene

Disorders for TFDP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TFDP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
- elite association - COSMIC cancer census association via MalaCards
Search TFDP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TFDP1

Genetic Association Database (GAD)
TFDP1
Human Genome Epidemiology (HuGE) Navigator
TFDP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFDP1
genes like me logo Genes that share disorders with TFDP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TFDP1 Gene

Publications for TFDP1 Gene

  1. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PMID: 8405995) Helin K. … Harlow E. (Genes Dev. 1993) 3 4 23 67
  2. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y. … Chellappan S.P. (Genomics 1997) 2 3 23
  3. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. (PMID: 15536069) Attwooll C. … Helin K. (J. Biol. Chem. 2005) 3 23
  4. Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner. (PMID: 15863509) Ishida H. … Hanazawa S. (J. Biol. Chem. 2005) 3 23
  5. Association of over-expressed TFDP1 with progression of hepatocellular carcinomas. (PMID: 14618416) Yasui K. … Inazawa J. (J. Hum. Genet. 2003) 3 23

Products for TFDP1 Gene

Sources for TFDP1 Gene

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