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TFDP1 Gene

protein-coding   GIFtS: 67
GCID: GC13P114239

Transcription Factor Dp-1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor Dp-11 2     E2F Dimerization Partner 12 3
DP12 3 5     Dp-12
DRTF12 3 5     E2F-Related Transcription Factor2
DRTF1-Polypeptide 12 3     

External Ids:    HGNC: 117491   Entrez Gene: 70272   Ensembl: ENSG000001981767   OMIM: 1899025   UniProtKB: Q141863   

Export aliases for TFDP1 gene to outside databases

Previous GC identifers: GC13P112848 GC13P108876 GC13P113325 GC13P112187 GC13P113287 GC13P094679


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFDP1 Gene:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance
their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part
of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from
G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found
on chromosomes 1, 15, and X.(provided by RefSeq, Jan 2009)

GeneCards Summary for TFDP1 Gene:
TFDP1 (transcription factor Dp-1) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
apoptosis

Gene Wiki entry for TFDP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_027140.7  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFDP1 gene promoter:
         POU2F1   POU2F1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TFDP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFDP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

TFDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P114239:  view genomic region     (about GC identifiers)

Start:
114,239,003 bp from pter      End:
114,295,788 bp from pter
Size:
56,786 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186 (See protein sequence)
Recommended Name: Transcription factor Dp-1  
Size: 410 amino acids; 45070 Da
Subunit: Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The
complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that
inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC).
During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the
DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7,
are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0
phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of
the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1,
MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell
cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds
to MYBL2
Miscellaneous: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP
1 PDB 3D structure from and Proteopedia for TFDP1:
2AZE (3D)    
Secondary accessions: Q5JSB4 Q8IZL5

Explore the universe of human proteins at neXtProt for TFDP1: NX_Q14186

Explore proteomics data for TFDP1 at MOPED

Post-translational modifications: 

  • Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation1
  • Ubiquitination2 at Lys44, Lys190, Lys234, Lys320
  • Modification sites at PhosphoSitePlus

  • See TFDP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009042.1  
    ENSEMBL proteins: 
     ENSP00000364519   ENSP00000386145   ENSP00000401389   ENSP00000443878   ENSP00000438450  
    Reactome Protein details: Q14186

    TFDP1 Human Recombinant Protein Products:

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    Novus Biologicals TFDP1 Proteins
    Novus Biologicals TFDP1 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TFDP1

     
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    antibodies-online proteins for TFDP1 (3 products) 

     
    antibodies-online peptides for TFDP1

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    antibodies-online antibodies for TFDP1 (63 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR014889 Transc_factor_DP_C
     IPR011991 WHTH_DNA-bd_dom
     IPR015648 Transcrpt_fac_DP
     IPR028313 DP-1

    Graphical View of Domain Structure for InterPro Entry Q14186

    ProtoNet protein and cluster: Q14186

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
    Similarity: Belongs to the E2F/DP family


    Find genes that share domains with TFDP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFDP1_HUMAN, Q14186
    Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
    E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
    involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
    cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
    apoptosis
    Induction: Down-regulated during differentiation

         Genatlas biochemistry entry for TFDP1:
    transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in
    esophageal squamous cell carcinoma

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity IEA--
    GO:0005515protein binding IPI16360038
    GO:0008134transcription factor binding IPI16360038
         
    Find genes that share ontologies with TFDP1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TFDP1:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cell number in S 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tfdp1):
     embryogenesis  growth/size/body  mortality/aging  nervous system  tumorigenesis 

    Find genes that share phenotypes with TFDP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tfdp1tm1Lili for TFDP1

       genOway: Develop your customized and physiologically relevant rodent model for TFDP1

    miRNA
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    miRTarBase miRNAs that target TFDP1:
    hsa-mir-935 (MIRT036682)

    Block miRNA regulation of human, mouse, rat TFDP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFDP1 (see all 21):
    hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidTFDP1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for TFDP1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFDP1_HUMAN, Q14186: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with TFDP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TFDP1 About   (see all 27)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    G1 to S cell cycle control0.35
    Inhibition of replication initiation of damaged DNA by RB1/E2F10.00
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    5Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of NOXA and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    Activation of PUMA and translocation to mitochondria0.00


    Find genes that share SuperPaths with TFDP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TFDP1
        G1-S Phase Transition
    Estrogen-mediated S-Phase Entry
    Cyclins and Cell Cycle Regulation
    MNAR-PELP1 and Estrogen Receptor Interaction

    5 GeneGo (Thomson Reuters) Pathways for TFDP1
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Transition and termination of DNA replication
    Cell cycle Cell cycle (generic schema)
    Cell cycle Start of DNA replication in early S phase

    Selected BioSystems Pathways for TFDP1 (see all 8)
        Cell cycle
    G1 to S cell cycle control
    TGF-beta Receptor Signaling Pathway
    RB in Cancer
    E2F transcription factor network


    Selected Reactome Pathways for TFDP1 (see all 11)
        G0 and Early G1
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Oncogene Induced Senescence
    Activation of NOXA and translocation to mitochondria
    Activation of PUMA and translocation to mitochondria


    2 Kegg Pathways  (Kegg details for TFDP1):
        Cell cycle
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including TFDP1: 
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TFDP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TFDP1 (Q141861, 2, 3 ENSP000003645194) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010941, 2, 3, ENSP000003455714EBI-749713,EBI-448924 MINT-8381834 MINT-8381854 I2D: score=4 STRING: ENSP00000345571
    DVL1O146401, 2EBI-749713,EBI-723489 MINT-8404114 MINT-8404100 MINT-8404082
    NLKQ9UBE81, 2EBI-749713,EBI-366978 MINT-8403941 MINT-8403953
    BAG6P463793I2D: score=3 
    ENSG00000096155P463793I2D: score=3 
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    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8405995

    Find genes that share ontologies with TFDP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFDP1

    1 Novoseek inferred chemical compound relationship for TFDP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0 2 12029633 (1)



    Find genes that share compounds with TFDP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TFDP1 gene: 
    NM_007111.4  

    Unigene Cluster for TFDP1:

    Transcription factor Dp-1
    Hs.79353  [show with all ESTs]
    Unigene Representative Sequence: NM_007111
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475254 ENST00000464794(uc001vtv.3) ENST00000375370(uc010tkd.2 uc001vtw.3 uc010tke.2 uc001vty.4)
    ENST00000465174 ENST00000408980(uc010agx.3) ENST00000453989 ENST00000494812
    ENST00000538138 ENST00000544902
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    hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a
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      QuantiFast Probe-based Assays in human, mouse, rat TFDP1

    Additional mRNA sequence: 

    AK297114.1 AK298521.1 AK310401.1 AK313742.1 BC011685.2 BC036601.1 L23959.1 NR_026580.1 

    21 DOTS entries:

    DT.218350  DT.101964181  DT.405179  DT.100824113  DT.95203246  DT.100835726  DT.40247167  DT.92445730 
    DT.100824123  DT.120764051  DT.86857687  DT.95336151  DT.100824114  DT.100824115  DT.100824125  DT.95127613 
    DT.95134804  DT.100824120  DT.121350111  DT.91811411  DT.95111609 

    Selected AceView cDNA sequences (see all 401):

    BQ933494 CR614715 AW005416 N70946 AA642409 BQ436190 BM718399 CB852660 
    BE269676 CD364530 AV724328 AI468403 BU187839 BM683456 BM766221 AI360268 
    BF224431 F04606 BQ025624 BQ945665 BQ718346 BQ021225 BQ446215 CR616214 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
    SP1:                                                  -                                                                       -                                 
    SP2:                                                                                                                          -     -     -                     
    SP3:                          -     -                 -                                                                                                         
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                                          -           -                     

    ExUns: 16d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TFDP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFDP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTTTAA
    TFDP1 Expression
    About this image


    TFDP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
    TFDP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFDP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79353

    UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
    Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in
    lung and pancreas. Not detected in heart

        Pathway & Disease-focused RT2 Profiler PCR Array including TFDP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFDP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfdp11 , 5 transcription factor Dp 11, 5 87.48(n)1
    95.43(a)1
      8 (5.78 cM)5
    217811  NM_009361.21  NP_033387.11 
     133396745 
    chicken
    (Gallus gallus)
    Aves TFDP11 transcription factor Dp-1 80.88(n)
    91.12(a)
      418739  XM_004938529.1  XP_004938586.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    3(106250490-106306788)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331422 Xenopus laevis transcribed sequence with moderate similarity more 77.57(n)    CA793927.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044409.12   -- 76.81(n)    BC044409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dp3 dorsal/ventral axis determination,
    follicular more
    58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dpl-13 transcription factor DP-1 52(a)   II(9169866-9172120)   --


    ENSEMBL Gene Tree for TFDP1 (if available)
    TreeFam Gene Tree for TFDP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFDP1 gene
    TFDP32  TFDP22  
    2 SIMAP similar genes for TFDP1 using alignment to 5 protein entries:     TFDP1_HUMAN (see all proteins):
    TFDP2    TFDP3

    Find genes that share paralogs with TFDP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TFDP1
    PGOHUM00000246873 PGOHUM00000245193 PGOHUM00000232901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFDP1 (see all 1814)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413481211,2
    --95172473(+) AAGAAA/GCGGGT 2 -- us2k10--------
    rs73245991,2
    C,F,A--95172527(+) GGGTGC/TGGCGT 2 -- us2k16Minor allele frequency- T:0.10NA WA CSA EA 245
    rs73231791,2
    C,F,A--95172531(+) GCGGCG/CTTGCC 2 -- us2k16Minor allele frequency- C:0.11NA WA CSA EA 245
    rs1844260651,2
    --95172543(+) GAGGGA/GCAGGA 2 -- us2k10--------
    rs1431003531,2
    --95172618(+) AGAGGC/TCTTTG 2 -- us2k10--------
    rs362040841,2
    C--95172635(+) TCCTCA/GAGTCC 2 -- us2k10--------
    rs1411629251,2
    --95172665(+) CTCGGA/CGCGCA 2 -- us2k10--------
    rs1903951091,2
    --95172728(+) GCCCGC/TCCTTG 2 -- us2k10--------
    rs362040851,2
    C,F--95172759(+) CCCTAG/ACGGCG 2 -- us2k12Minor allele frequency- A:0.14WA 120
    rs1825664911,2
    C--95172760(+) CCTAGC/GGGCGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TFDP1 (114239003 - 114295788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TFDP1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748347CNV Deletion23290073
    esv2748340CNV Deletion23290073
    esv2748344CNV Deletion23290073
    esv2748342CNV Deletion23290073
    esv2748348CNV Deletion23290073
    esv2748345CNV Deletion23290073
    esv2748339CNV Deletion23290073
    esv2748343CNV Deletion23290073
    esv2748346CNV Deletion23290073
    esv2664676CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing TFDP1:
    Breast Cancer
    Lung Cancer
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TFDP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TFDP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189902    OMIM disorders: --


    Find genes that share disorders with TFDP1           About GenesLikeMe

    6 Novoseek inferred disease relationships for TFDP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.9 6 1297652 (1), 8964493 (1), 7784053 (1), 9322885 (1) (see all 6)
    tumors 27.5 5 17483321 (1), 12878869 (1), 7809128 (1), 9322885 (1) (see all 5)
    colon carcinoma 21.3 1 11052627 (1)
    breast carcinoma 7.31 3 17483321 (2), 11052627 (1)
    hepatocellular carcinoma 0 2 12029633 (1), 14618416 (1)
    carcinoma 0 1 14618416 (1)

    Genetic Association Database (GAD): TFDP1
    Human Genome Epidemiology (HuGE) Navigator: TFDP1 (2 documents)

    Export disorders for TFDP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFDP1 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with TFDP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PubMed id 8405995)1, 2, 9 Helin K....Harlow E. (Genes Dev. 1993)
    2. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PubMed id 8039504)1, 2, 9 Bandara L.R....la Thangue N.B. (EMBO J. 1994)
    3. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PubMed id 9027491)1, 3, 9 Zhang Y....Chellappan S.P. (Genomics 1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    6. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (Mol. Cell 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (Science 2002)
    9. In vivo association of E2F and DP family proteins. (PubMed id 7739537)1, 2 Wu C.-L.... Lees J.A. (Mol. Cell. Biol. 1995)
    10. A new component of the transcription factor DRTF1/E2F. (PubMed id 8413592)1, 3 Girling R....La Thangue N.B. (Nature 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7027 HGNC: 11749 AceView: TFDP1 Ensembl:ENSG00000198176 euGenes: HUgn7027
    ECgene: TFDP1 Kegg: 7027 H-InvDB: TFDP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFDP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFDP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tfdp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFDP1 gene:
    Search GeneIP for patents involving TFDP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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