Aliases for TFDP1 Gene
Aliases for TFDP1 Gene
External Ids for TFDP1 Gene
- HGNC: 11749
- Entrez Gene: 7027
- Ensembl: ENSG00000198176
- OMIM: 189902
- UniProtKB: Q14186
Previous GeneCards Identifiers for TFDP1 Gene
- GC13P112848
- GC13P108876
- GC13P113325
- GC13P112187
- GC13P113287
- GC13P114239
- GC13P094679
Summaries for TFDP1 Gene
-
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
GeneCards Summary for TFDP1 Gene
TFDP1 (Transcription Factor Dp-1) is a Protein Coding gene. Diseases associated with TFDP1 include Retinoblastoma. Among its related pathways are Cellular Senescence and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TFDP3.
UniProtKB/Swiss-Prot for TFDP1 Gene
-
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFDP1 Gene
Genomics for TFDP1 Gene
Regulatory Elements for TFDP1 Gene
Enhancers for TFDP1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13G113584 | 1 | ENCODE | 0.7 | +0.6 | 552 | 2.1 | WRNIP1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF766 GLIS2 ZNF143 ZNF263 | GRK1 TMCO3 TFDP1 PIR60549 |
| GH13G113583 | 0.8 | ENCODE | 0.7 | -1.4 | -1354 | 0.1 | PKNOX1 ZFP64 DMAP1 TCF12 ZNF766 ZBTB11 KAT8 MEF2D IKZF1 NR2C1 | TFDP1 ENSG00000276248 |
| GH13G113582 | 0.7 | ENCODE | 0.7 | -1.7 | -1668 | 0.2 | ZFP64 DMAP1 ZNF48 ZNF121 NCOR1 ADNP GATAD2A KAT8 GABPB1 ZNF580 | TMCO3 TFDP1 ENSG00000276248 |
| GH13G113544 | 1.1 | Ensembl ENCODE | 0.3 | -38.2 | -38193 | 4.9 | ARID4B KLF17 ZNF48 RARA SCRT2 EGR2 ZHX2 REST NR2F2 ZFP69B | TMCO3 DCUN1D2 ENSG00000267868 ENSG00000276248 TFDP1 |
| GH13G113562 | 1 | Ensembl ENCODE | 0.3 | -22.0 | -22011 | 1.0 | DRAP1 CTCF MXI1 PKNOX1 ZNF146 SAP130 ZIC2 THRB ZNF48 RAD21 | TMCO3 DCUN1D2 TFDP1 ENSG00000276248 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TFDP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TFDP1 gene promoter:
Regulatory Element Products
Genomic Location for TFDP1 Gene
- Chromosome:
- 13
- Start:
- 113,584,688 bp from pter
- End:
- 113,641,473 bp from pter
- Size:
- 56,786 bases
- Orientation:
- Plus strand
Genomic View for TFDP1 Gene
Genes around TFDP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q34 by Ensembl
- 13q34 by Entrez Gene
- 13q34 by HGNC
TFDP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TFDP1 Gene
Proteins for TFDP1 Gene
-
Protein details for TFDP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14186-TFDP1_HUMAN
- Recommended name:
- Transcription factor Dp-1
- Protein Accession:
- Q14186
- B4DLQ9
- Q5JSB4
- Q8IZL5
Protein attributes for TFDP1 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 45070 Da
- Quaternary structure:
-
- Component of the E2F:DP transcription factor complex. Forms heterodimers with E2F family members. The complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812).
- Miscellaneous:
-
- E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP.
Protein Expression for TFDP1 Gene
Post-translational modifications for TFDP1 Gene
- Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
- Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
- Ubiquitination at isoforms=44, posLast=190190, isoforms=2234, and posLast=320320
- Modification sites at PhosphoSitePlus
Other Protein References for TFDP1 Gene
Antibody Products
- Novus Biologicals Antibodies for TFDP1
-
Cloud-Clone Corp. Antibodies for TFDP1
- Invitrogen Antibodies for TFDP1
- antibodies-online Antibodies for TFDP1: See all 67
- GeneTex TFDP1 antibody for TFDP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TFDP1
Protein Products
-
OriGene Purified Proteins for TFDP1
- Search Origene for MassSpec and Protein Over-expression Lysates for TFDP1
- Origene Custom Protein Services for TFDP1
-
Cloud-Clone Corp. Proteins for TFDP1
- antibodies-online Proteins for TFDP1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TFDP1
Assay Products
- antibodies-online Kits for TFDP1: See all 1
No data available for DME Specific Peptides for TFDP1 Gene
Domains & Families for TFDP1 Gene
Gene Families for TFDP1 Gene
Protein Domains for TFDP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TFDP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14186- Family:
-
- Belongs to the E2F/DP family.
Function for TFDP1 Gene
Molecular function for TFDP1 Gene
- GENATLAS Biochemistry:
- transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in esophageal squamous cell carcinoma
- UniProtKB/Swiss-Prot Function:
- Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during differentiation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS,IEA | 8405995 |
| GO:0003713 | transcription coactivator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for TFDP1 Gene
- MGI mutant phenotypes for TFDP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TFDP1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- G0/1 arrest
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell number in S
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Increased Nanog expression
- Increased shRNA abundance with PLX4720
Animal Models for TFDP1 Gene
- MGI Knock Outs for TFDP1:
-
- Tfdp1 tm1Lili
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TFDP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TFDP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TFDP1 gene
- Search ViGene Biosciences for TFDP1
CRISPR Products
-
OriGene CRISPR knockouts for TFDP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFDP1
- GenScript: Design CRISPR guide RNA sequences for TFDP1
miRNA for TFDP1 Gene
- miRTarBase miRNAs that target TFDP1
-
- hsa-mir-935 (MIRT036682)
- hsa-mir-30a-5p (MIRT067975)
- hsa-mir-30c-5p (MIRT067976)
- hsa-mir-30d-5p (MIRT067977)
- hsa-mir-30b-5p (MIRT067978)
- hsa-mir-30e-5p (MIRT067979)
- hsa-mir-374a-5p (MIRT067980)
- hsa-mir-410-3p (MIRT067981)
- hsa-mir-374b-5p (MIRT067983)
- hsa-mir-4495 (MIRT067985)
- hsa-mir-2113 (MIRT189199)
- hsa-mir-5010-3p (MIRT189201)
- hsa-mir-3646 (MIRT275730)
- hsa-let-7c-3p (MIRT275735)
- hsa-mir-185-5p (MIRT275736)
- hsa-mir-3177-5p (MIRT275740)
- hsa-mir-4306 (MIRT275741)
- hsa-mir-4311 (MIRT275742)
- hsa-mir-4270 (MIRT275743)
- hsa-mir-4441 (MIRT275744)
- hsa-mir-4644 (MIRT275745)
- hsa-mir-6731-5p (MIRT275748)
- hsa-mir-6754-5p (MIRT275749)
- hsa-mir-6760-5p (MIRT275750)
- hsa-mir-8085 (MIRT275751)
- hsa-mir-513a-3p (MIRT275753)
- hsa-mir-513c-3p (MIRT275755)
- hsa-mir-3606-3p (MIRT275756)
- hsa-mir-143-5p (MIRT275763)
- hsa-mir-569 (MIRT275764)
- hsa-mir-629-5p (MIRT275766)
- hsa-mir-3611 (MIRT275768)
- hsa-mir-4506 (MIRT275771)
- hsa-mir-6839-3p (MIRT275773)
- hsa-mir-1252-3p (MIRT339918)
- hsa-mir-3134 (MIRT466412)
- hsa-mir-8082 (MIRT466413)
- hsa-mir-4534 (MIRT466414)
- hsa-mir-5003-5p (MIRT466415)
- hsa-mir-511-5p (MIRT520753)
- hsa-mir-6830-3p (MIRT520754)
- hsa-mir-302d-5p (MIRT520755)
- hsa-mir-302b-5p (MIRT520756)
- hsa-mir-380-3p (MIRT520757)
- hsa-mir-411-3p (MIRT520758)
- hsa-mir-379-3p (MIRT520759)
- hsa-mir-5692b (MIRT546338)
- hsa-mir-5692c (MIRT546339)
- hsa-mir-369-3p (MIRT546340)
- hsa-mir-758-3p (MIRT565404)
- hsa-mir-1257 (MIRT565405)
miRNA Products
- Search ViGene Biosciences for TFDP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TFDP1
- Browse OriGene Inhibitory RNA Products For TFDP1
-
ViGene Biosciences ready-to-package AAV shRNAs for TFDP1 gene
Clone Products
-
OriGene ORF clones in human for TFDP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TFDP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TFDP1
- VectorBuilder custom plasmid, inducible vectors for TFDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFDP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TFDP1
-
ViGene Biosciences adenoviral particle packaged cDNA for TFDP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TFDP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TFDP1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TFDP1 Gene
Localization for TFDP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TFDP1 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250 UniProtKB:Q08639}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for TFDP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cyclins and Cell Cycle Regulation |
.31
|
|
| 2 | Activation of BH3-only proteins | ||
| 3 | E2F mediated regulation of DNA replication | ||
| 4 | Cellular Senescence | ||
| 5 | Cell cycle Cell cycle (generic schema) |
.31
|
|
Pathways by source for TFDP1 Gene
8 BioSystems pathways for TFDP1 Gene
32 Reactome pathways for TFDP1 Gene
2 KEGG pathways for TFDP1 Gene
5 GeneGo (Thomson Reuters) pathways for TFDP1 Gene
4 Qiagen pathways for TFDP1 Gene
Interacting Proteins for TFDP1 Gene
Selected Interacting proteins:
ENSP00000364519
Q14186-TFDP1_HUMAN
for TFDP1 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 8405995 |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
No data available for SIGNOR curated interactions for TFDP1 Gene
Transcripts for TFDP1 Gene
mRNA/cDNA for TFDP1 Gene
- (13) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (401) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TFDP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TFDP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TFDP1
- GenScript: Design CRISPR guide RNA sequences for TFDP1
miRNA Products
- Search ViGene Biosciences for TFDP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TFDP1
- Browse OriGene Inhibitory RNA Products For TFDP1
-
ViGene Biosciences ready-to-package AAV shRNAs for TFDP1 gene
Clone Products
-
OriGene ORF clones in human for TFDP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TFDP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TFDP1
- VectorBuilder custom plasmid, inducible vectors for TFDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFDP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - |
| ExUns: | 16d |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Expression for TFDP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Testis (Reproductive System)
-
Ovary (Reproductive System)
This gene is overexpressed in Testis (36.2), Fetal heart (13.5), and Fetal Liver (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TFDP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of TFDP1 Gene:
TFDP1SOURCE GeneReport for Unigene cluster for TFDP1 Gene:
Hs.79353mRNA Expression by UniProt/SwissProt for TFDP1 Gene:
Q14186-TFDP1_HUMAN
Tissue specificity:
Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
Evidence on tissue expression from TISSUES for TFDP1 Gene
- Muscle(4.3)
- Nervous system(3.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for TFDP1
-
OriGene qPCR primer pairs for TFDP1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TFDP1 Gene
Orthologs for TFDP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TFDP1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| TFDP1 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Tfdp1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | MGC112830 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TFDP1 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| TFDP1 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tfdp1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33142 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tfdp1a 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10859 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dp 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | dpl-1 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4055 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4637 34 |
|
- Species where no ortholog for TFDP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TFDP1 Gene
(2) SIMAP similar genes for TFDP1 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for TFDP1 Gene
Variants for TFDP1 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000133715 | -- | 113,627,421(+) | GAAGT(C/T)GGCAT | intron-variant | |
| rs1000179126 | -- | 113,630,488(+) | GAGCT(-/G)GGGGG | intron-variant | |
| rs1000212320 | -- | 113,589,204(+) | ACTTA(C/T)TTGAA | intron-variant | |
| rs1000236497 | -- | 113,630,538(+) | GCCCC(A/C/G)CCGCC | intron-variant | |
| rs1000254296 | -- | 113,626,148(+) | GTGTC(C/T)CTCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1133e59 | CNV | duplication | 20981092 |
| esv23154 | CNV | loss | 19812545 |
| esv2664676 | CNV | deletion | 23128226 |
| esv2748339 | CNV | deletion | 23290073 |
| esv2748340 | CNV | deletion | 23290073 |
| esv2748342 | CNV | deletion | 23290073 |
| esv2748343 | CNV | deletion | 23290073 |
| esv2748344 | CNV | deletion | 23290073 |
| esv2748345 | CNV | deletion | 23290073 |
| esv2748346 | CNV | deletion | 23290073 |
| esv2748347 | CNV | deletion | 23290073 |
| esv2748348 | CNV | deletion | 23290073 |
| esv3390681 | CNV | duplication | 20981092 |
| esv3551159 | CNV | deletion | 23714750 |
| nsv1048814 | CNV | gain | 25217958 |
| nsv1071131 | CNV | deletion | 25765185 |
| nsv1121869 | CNV | deletion | 24896259 |
| nsv1143743 | CNV | deletion | 24896259 |
| nsv1145981 | CNV | duplication | 26484159 |
| nsv1151671 | CNV | deletion | 26484159 |
| nsv1152323 | CNV | deletion | 26484159 |
| nsv509523 | CNV | insertion | 20534489 |
| nsv563380 | CNV | loss | 21841781 |
| nsv820428 | CNV | duplication | 20802225 |
| nsv832726 | CNV | loss | 17160897 |
| nsv951929 | CNV | deletion | 24416366 |
| nsv983621 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.10% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TFDP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFDP1 Gene
Disorders for TFDP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
Search TFDP1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TFDP1
No data available for UniProtKB/Swiss-Prot and Genatlas for TFDP1 Gene
Publications for TFDP1 Gene
- Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PMID: 9027491) Zhang Y. … Chellappan S.P. (Genomics 1997) 2 3 22 64
- DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PMID: 8039504) Bandara L.R. … la Thangue N.B. (EMBO J. 1994) 3 4 22 64
- Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PMID: 8405995) Helin K. … Harlow E. (Genes Dev. 1993) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Repression of transcriptional activity of C/EBPalpha by E2F- dimerization partner complexes. (PMID: 20176812) Zaragoza K. … Leutz A. (Mol. Cell. Biol. 2010) 3 4 64
Products for TFDP1 Gene
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- Custom Antibody ServicesOriGene Antibodies for TFDP1
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- Addgene plasmids for TFDP1
- antibodies-online Antibodies for TFDP1: See all 67
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- antibodies-online Proteins for TFDP1: See all 5
- Search antibodies-online for peptides
- GeneTex TFDP1 antibody for TFDP1
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- Santa Cruz Biotechnology (SCBT) CRISPR for TFDP1
- Horizon Cell Lines for TFDP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for TFDP1
- VectorBuilder custom plasmid, inducible vectors for TFDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TFDP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TFDP1 Gene
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- (74) Cloud-Clone Corp.
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