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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFDP1 Gene

protein-coding   GIFtS: 66
GCID: GC13P114239

Transcription Factor Dp-1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transcription Factor Dp-11 2     E2F Dimerization Partner 12 3
DP12 3 5     Dp-12
DRTF12 3 5     E2F-Related Transcription Factor2
DRTF1-Polypeptide 12 3     

External Ids:    HGNC: 117491   Entrez Gene: 70272   Ensembl: ENSG000001981767   OMIM: 1899025   UniProtKB: Q141863   
ORGUL members:         
NONCODE14:n407162      

Export aliases for TFDP1 gene to outside databases

Previous GC identifers: GC13P112848 GC13P108876 GC13P113325 GC13P112187 GC13P113287 GC13P094679


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFDP1 Gene:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance
their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part
of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from
G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found
on chromosomes 1, 15, and X.(provided by RefSeq, Jan 2009)

GeneCards Summary for TFDP1 Gene: 
TFDP1 (transcription factor Dp-1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TFDP1 include differentiating neuroblastoma, and cytomegalovirus infection, and among its related super-pathways are G1-S Phase Transition and Cell cycle Regulation of G1/S transition (part 2). GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFDP3.

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
apoptosis

Gene Wiki entry for TFDP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_027140.6  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFDP1 gene promoter:
         POU2F1   POU2F1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TFDP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

TFDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFDP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P114239:  view genomic region     (about GC identifiers)

Start:
114,239,003 bp from pter      End:
114,295,788 bp from pter
Size:
56,786 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186 (See protein sequence)
Recommended Name: Transcription factor Dp-1  
Size: 410 amino acids; 45070 Da
Subunit: Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The
complex can interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that
inhibit the E2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC).
During the cell cycle, from mid-to-late G1 phase, RB family members become phosphorylated, detach from the
DRTF1/E2F complex to render E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7,
are capable of sequestering RB protein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0
phase is composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of
the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1,
MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell
cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds
to MYBL2
Subcellular location: Nucleus
Miscellaneous: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP
1 PDB 3D structure from and Proteopedia for TFDP1:
2AZE (3D)    
Secondary accessions: Q5JSB4 Q8IZL5

Explore the universe of human proteins at neXtProt for TFDP1: NX_Q14186

Explore proteomics data for TFDP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14186

  • TFDP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFDP1 Protein Expression
    REFSEQ proteins: NP_009042.1  
    ENSEMBL proteins: 
     ENSP00000364519   ENSP00000386145   ENSP00000401389   ENSP00000443878   ENSP00000438450  
    Reactome Protein details: Q14186
    Human Recombinant Protein Products for TFDP1: 
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    OriGene MassSpec for TFDP1 
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    GenScript Custom Purified and Recombinant Proteins Services for TFDP1
    Novus Biologicals TFDP1 Proteins
    Novus Biologicals TFDP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TFDP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    TFDP1 for ontologies           About GeneDecksing



    TFDP1 Antibody Products: 
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    ThermoFisher Antibody for TFDP1
    LSBio Antibodies in human, mouse, rat for TFDP1 

    Assay Products for TFDP1: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TFDP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TFDP1 
    Cloud-Clone Corp. CLIAs for TFDP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR003316 E2F_TDP
     IPR014889 Transc_factor_DP_C
     IPR011991 WHTH_DNA-bd_dom
     IPR015648 Transcrpt_fac_DP
     IPR016556 Transcription_factor_DP_subgr

    Graphical View of Domain Structure for InterPro Entry Q14186

    ProtoNet protein and cluster: Q14186

    1 Blocks protein domain: IPB003316 Transcription factor E2F/dimerisation partner (TDP)

    UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
    Similarity: Belongs to the E2F/DP family


    TFDP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFDP1_HUMAN, Q14186
    Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the
    E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are
    involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of
    cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and
    apoptosis
    Induction: Down-regulated during differentiation

         Genatlas biochemistry entry for TFDP1:
    transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in
    esophageal squamous cell carcinoma

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS8405995
    GO:0005515protein binding IPI16360038
    GO:0008134transcription factor binding IPI16360038
         
    TFDP1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TFDP1:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cell number in S 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tfdp1):
     embryogenesis  growth/size  mortality/aging  nervous system  tumorigenesis 

    TFDP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tfdp1tm1Lili for TFDP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFDP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TFDP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFDP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFDP1 

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate TFDP1 (see all 21):
    hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidTFDP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TFDP1 (NM_007111)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP1
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                         Customized lentivirus expression plasmids for stable overexpression of TFDP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TFDP1 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    2Cell cycle Cell cycle (generic schema)
    Cell cycle Cell cycle (generic schema)0.38
    Cell cycle ESR1 regulation of G1/S transition0.33
    Cell cycle Regulation of G1/S transition (part 2)0.38
    G0 and Early G10.31
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    4Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for TFDP1
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Transition and termination of DNA replacation
    Cell cycle Start of DNA replication in early S phase
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Cell cycle (generic schema)

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TFDP1
        G1-S Phase Transition
    Estrogen-mediated S-Phase Entry
    Cyclins and Cell Cycle Regulation
    MNAR-PELP1 and Estrogen Receptor Interaction

    5 GeneGo (Thomson Reuters) Pathways for TFDP1
        Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Transition and termination of DNA replication
    Cell cycle Cell cycle (generic schema)
    Cell cycle Start of DNA replication in early S phase

    5/7 BioSystems Pathways for TFDP1 (see all 7)
        Cell cycle
    G1 to S cell cycle control
    TGF-beta Receptor Signaling Pathway
    Regulation of retinoblastoma protein
    Direct p53 effectors

    5/15        Reactome Pathways for TFDP1 (see all 15)
        G1 Phase
    Generic Transcription Pathway
    Mitotic G1-G1/S phases
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    G0 and Early G1


    2         Kegg Pathways  (Kegg details for TFDP1):
        Cell cycle
    TGF-beta signaling pathway


    TFDP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFDP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/141 Interacting proteins for TFDP1 (Q141862, 3 ENSP000003645194) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010942, 3, ENSP000003455714MINT-8381834 MINT-8381854 I2D: score=4 STRING: ENSP00000345571
    BAG6P463793I2D: score=3 
    ENSG00000096155P463793I2D: score=3 
    ENSG00000227761P463793I2D: score=3 
    ENSG00000228760P463793I2D: score=3 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8405995

    TFDP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFDP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFDP1

    1 Novoseek inferred chemical compound relationship for TFDP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0 2 12029633 (1)

    Search CenterWatch for drugs/clinical trials and news about TFDP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFDP1 gene: 
    NM_007111.4  

    Unigene Cluster for TFDP1:

    Transcription factor Dp-1
    Hs.79353  [show with all ESTs]
    Unigene Representative Sequence: NM_007111
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475254 ENST00000464794(uc001vtv.3) ENST00000375370(uc010tkd.2 uc001vtw.3 uc010tke.2 uc001vty.4)
    ENST00000465174 ENST00000408980(uc010agx.3) ENST00000453989 ENST00000494812
    ENST00000538138 ENST00000544902
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate TFDP1 (see all 21):
    hsa-miR-411* hsa-miR-30c hsa-miR-1226 hsa-miR-379* hsa-miR-374a hsa-miR-30d hsa-miR-340 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidTFDP1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK297114.1 AK298521.1 AK310401.1 AK313742.1 BC011685.2 BC036601.1 L23959.1 NR_026580.1 

    21 DOTS entries:

    DT.218350  DT.101964181  DT.405179  DT.100824113  DT.95203246  DT.100835726  DT.40247167  DT.92445730 
    DT.100824123  DT.120764051  DT.86857687  DT.95336151  DT.100824114  DT.100824115  DT.100824125  DT.95127613 
    DT.95134804  DT.100824120  DT.121350111  DT.91811411  DT.95111609 

    24/401 AceView cDNA sequences (see all 401):

    W76051 BM772419 CR616214 BU631042 BF061081 BQ428249 CR603875 BU633558 
    AA642409 AI365066 BM701830 BU619132 CB120535 F04606 BQ933494 BQ214205 
    AI470818 W35399 BM718399 BM464943 BM766249 N70946 AI160089 BU859276 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
    SP1:                                                  -                                                                       -                                 
    SP2:                                                                                                                          -     -     -                     
    SP3:                          -     -                 -                                                                                                         
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                                          -           -                     

    ExUns: 16d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TFDP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFDP1 expression in normal human tissues (normalized intensities)      TFDP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTTTAA
    TFDP1 Expression
    About this image


    TFDP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             monocyte-derived macrophage   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)

    See TFDP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFDP1

    SOURCE GeneReport for Unigene cluster: Hs.79353

    UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186
    Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in
    lung and pancreas. Not detected in heart

        SABiosciences Expression via Pathway-Focused PCR Array including TFDP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TFDP1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfdp11 , 5 transcription factor Dp 11, 5 87.15(n)1
    94.88(a)1
      8 (5.78 cM)5
    217811  NM_009361.21  NP_033387.11 
     133396745 
    chicken
    (Gallus gallus)
    Aves TFDP11 transcription factor Dp-1 80.65(n)
    90.49(a)
      418739  XM_416938.2  XP_416938.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    90(a)
    1 → many
    3(106250490-106306788)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331422 Xenopus laevis transcribed sequence with moderate similarity more 77.57(n)    CA793927.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044409.12   -- 76.81(n)    BC044409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dp3 dorsal/ventral axis determination,
    follicular more
    58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dpl-13 transcription factor DP-1 52(a)   II(9169866-9172120)   --


    ENSEMBL Gene Tree for TFDP1 (if available)
    TreeFam Gene Tree for TFDP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFDP1 gene
    TFDP32  TFDP22  
    2 SIMAP similar genes for TFDP1 using alignment to 5 protein entries:     TFDP1_HUMAN (see all proteins):
    TFDP2    TFDP3

    TFDP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TFDP1
    PGOHUM00000246873 PGOHUM00000245193 PGOHUM00000232901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1814 SNPs in TFDP1 are shown (see all 1814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413481211,2
    --95172473(+) AAGAAA/GCGGGT 2 -- us2k10--------
    rs73245991,2
    C,F,A--95172527(+) GGGTGC/TGGCGT 2 -- us2k16Minor allele frequency- T:0.10NA WA CSA EA 245
    rs73231791,2
    C,F,A--95172531(+) GCGGCG/CTTGCC 2 -- us2k16Minor allele frequency- C:0.11NA WA CSA EA 245
    rs1844260651,2
    --95172543(+) GAGGGA/GCAGGA 2 -- us2k10--------
    rs1431003531,2
    --95172618(+) AGAGGC/TCTTTG 2 -- us2k10--------
    rs362040841,2
    C--95172635(+) TCCTCA/GAGTCC 2 -- us2k10--------
    rs1411629251,2
    --95172665(+) CTCGGA/CGCGCA 2 -- us2k10--------
    rs1903951091,2
    --95172728(+) GCCCGC/TCCTTG 2 -- us2k10--------
    rs362040851,2
    C,F--95172759(+) CCCTAG/ACGGCG 2 -- us2k12Minor allele frequency- A:0.14WA 120
    rs1825664911,2
    C--95172760(+) CCTAGC/GGGCGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TFDP1 (114239003 - 114295788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for TFDP1 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748347CNV Deletion23290073
    esv2748340CNV Deletion23290073
    esv2748344CNV Deletion23290073
    esv2748342CNV Deletion23290073
    esv2748348CNV Deletion23290073
    esv2748345CNV Deletion23290073
    esv2748339CNV Deletion23290073
    esv2748343CNV Deletion23290073
    esv2748346CNV Deletion23290073
    esv2664676CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    Breast Cancer
    Lung Cancer
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189902    OMIM disorders: --

    15 diseases for TFDP1:    About MalaCards
    differentiating neuroblastoma    cytomegalovirus infection    retinoblastoma    familial adenomatous polyposis
    neuroblastoma    lung adenocarcinoma    esophageal squamous cell carcinoma    non-hodgkin lymphoma
    hodgkin's lymphoma    hepatocellular carcinoma    esophagitis    squamous cell carcinoma
    adenocarcinoma    ovarian cancer    breast cancer


    TFDP1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for TFDP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.9 6 1297652 (1), 8964493 (1), 7784053 (1), 9322885 (1) (see all 6)
    tumors 27.5 5 17483321 (1), 12878869 (1), 7809128 (1), 9322885 (1) (see all 5)
    colon carcinoma 21.3 1 11052627 (1)
    breast carcinoma 7.31 3 17483321 (2), 11052627 (1)
    hepatocellular carcinoma 0 2 12029633 (1), 14618416 (1)
    carcinoma 0 1 14618416 (1)

    Genetic Association Database (GAD): TFDP1
    Human Genome Epidemiology (HuGE) Navigator: TFDP1 (2 documents)

    Export disorders for TFDP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFDP1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with TFDP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PubMed id 8405995)1, 2, 9 Helin K....Harlow E. (1993)
    2. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PubMed id 8039504)1, 2, 9 Bandara L.R....la Thangue N.B. (1994)
    3. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PubMed id 9027491)1, 3, 9 Zhang Y....Chellappan S.P. (1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    6. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (2002)
    9. In vivo association of E2F and DP family proteins. (PubMed id 7739537)1, 2 Wu C.-L.... Lees J.A. (1995)
    10. A new component of the transcription factor DRTF1/E2F. (PubMed id 8413592)1, 3 Girling R....La Thangue N.B. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7027 HGNC: 11749 AceView: TFDP1 Ensembl:ENSG00000198176 euGenes: HUgn7027
    ECgene: TFDP1 Kegg: 7027 H-InvDB: TFDP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFDP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFDP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tfdp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFDP1 gene:
    Search GeneIP for patents involving TFDP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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