TFDP1 Gene
protein-coding GIFtS: 65
GCID: GC13P114239
|
|
transcription factor Dp-1
| |
Aliases
for TFDP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Transcription Factor Dp-11 2 | | DRTF1-Polypeptide 12 3 | | DP11 2 3 5 | | E2F Dimerization Partner 12 3 | | DRTF11 2 3 5 | | E2F-Related Transcription Factor2 | | Dp-11 2 | | |
| External Ids: | HGNC: 117491 | Entrez Gene: 70272 | Ensembl: ENSG000001981767 | OMIM: 1899025 | UniProtKB: Q141863 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n407162 | |
Export aliases for TFDP1 gene to outside databasesPrevious GC identifers: GC13P112848 GC13P108876 GC13P113325 GC13P112187 GC13P113287 GC13P094679
Summaries
for TFDP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TFDP1:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance theirDNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of thiscomplex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to Sphase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes1, 15, and X.(provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved incell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progressionfrom G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis
Gene Wiki entry for TFDP1
|
Genomic Views
for TFDP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_027140.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TFDP1 gene promoter:
POU2F1 POU2F1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TFDP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34TFDP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P114239: view genomic region
(about GC identifiers)
Start:
|
114,239,003 bp from pter |
End:
|
114,295,788 bp from pter |
Size:
|
56,786 bases |
Orientation:
|
plus strand |
|
Proteins
for TFDP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186 (See
protein sequence)Recommended Name: Transcription factor Dp-1 Size: 410 amino acids; 45070 Da
Subunit: Component of the E2F/DP transcription factor complex. Forms heterodimers with E2F family members. The complexcan interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (RBL1 and RBL2) that inhibit theE2F transactivation domain. This repression involves recruitment of histone deacetylase (HDAC). During the cell cycle,from mid-to-late G1 phase, RB family members become phosphorylated, detach from the DRTF1/E2F complex to render E2Ftranscriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RBprotein, thus releasing the active complex. Part of the E2F6.com-1 complex in G0 phase is composed of E2F6, MGA, MAX,TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 YAF2. Component of the DREAM complex (also named LINCcomplex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2.The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase whenLIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2
Subcellular location: Nucleus
Miscellaneous: E2F/DP transactivation can be mediated by several cofactors including TBP, TFIIH, MDM2 and CBP
1 PDB 3D structure from  and Proteopedia  for TFDP1:2AZE (3D)
Secondary accessions: Q5JSB4 Q8IZL5Explore the universe of human proteins at neXtProt for TFDP1: NX_Q14186
Post-translational modifications:
Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14186
TFDP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009042.1
ENSEMBL proteins: ENSP00000364519 ENSP00000386145 ENSP00000401389 ENSP00000443878 ENSP00000438450 Reactome Protein details: Q14186
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- | | GO:0005667 | transcription factor complex |
IEA | -- |
TFDP1 for ontologies About GeneDecksing
TFDP1 Antibody Products:
Assay Products for TFDP1: |
Protein
Domains /
Families
for TFDP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TFDP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14186ProtoNet protein and cluster: Q14186 1 Blocks protein family: IPB003316 Transcription factor E2F/dimerisation partner (TDP)
UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186Similarity: Belongs to the E2F/DP family |
Function
for TFDP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved incell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progressionfrom G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosisInduction: Down-regulated during differentiation Genatlas biochemistry entry for TFDP1:transcription factor 1,heterodimerizing with E2F family member,ubiquitously expressed,highly amplified in esophagealsquamous cell carcinoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TFDP1 (NM_007111) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TFDP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TFDP1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TFDP1:
Animal Models:
Mouse knock-out Tfdp1tm1Lili for TFDP1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tfdp1):
TFDP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TFDP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Cell cycle (generic schema) | | | 2 | Cyclins and Cell Cycle Regulation | | | 3 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 4 | Cell cycle | | | 5 | Cell cycle_Start of DNA replication in early S phase | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for TFDP1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TFDP1
5  GeneGo (Thomson Reuters) Pathways for TFDP1
5/7  BioSystems Pathways for TFDP1 (see all 7)
5/15 
Reactome Pathways for TFDP1 (see all 15)
2 
Kegg Pathways (Kegg details for TFDP1):
TFDP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFDP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/135 Interacting proteins for TFDP1 (Q141862, 3 ENSP000003645194) via UniProtKB, MINT, STRING, and/or I2D (see all 135)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000080 | G1 phase of mitotic cell cycle |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 8405995 |
TFDP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TFDP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TFDP1 for compounds About GeneDecksing
 Browse Tocris compounds for TFDP1
1 Novoseek chemical compound relationship for TFDP1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oligonucleotide |
0 |
2 |
12029633 (1) |
Search CenterWatch for drugs/clinical trials and news about TFDP1
|
Transcripts
for TFDP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TFDP1 gene: NM_007111.4 Unigene Cluster for TFDP1: Transcription factor Dp-1 Hs.79353 [show with all ESTs]Unigene Representative Sequence: NM_0071119 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475254 ENST00000464794(uc001vtv.3) ENST00000375370(uc010tkd.2 uc001vtw.3 uc010tke.2 uc001vty.4)
ENST00000465174 ENST00000408980(uc010agx.3) ENST00000453989 ENST00000494812
ENST00000538138 ENST00000544902
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TFDP1 (NM_007111) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TFDP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP1 |
Additional cDNA sequence: AK297114.1 AK298521.1 AK310401.1 AK313742.1 BC011685.2 BC036601.1 L23959.1 NR_026580.1 22 DOTS entries: DT.218350 DT.101964181 DT.405179 DT.100824113 DT.95203246 DT.100835726 DT.40247167 DT.86857687 DT.91811411 DT.92445730 DT.100824123 DT.120764051 DT.100824114 DT.95331459 DT.95336151 DT.100824115 DT.100824120 DT.100824125 DT.95127613 DT.95134804 DT.121350111 DT.95111609 24/401 AceView cDNA sequences (see all 401): AI360268 BF510210 BQ774823 BG393642 CR614715 N70946 BU187839 W35399 BE296704 AA642409 BM753203 BM765797 CB120535 BI964021 BM743802 NM_007111 BQ214205 BF224431 BC011685 AI365066 BX092107 BM766221 CR603875 BQ421320
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TFDP1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | |
| ExUns: | 16d |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for TFDP1
|
Expression
for TFDP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TFDP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATTTTAA
About this image
See TFDP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFDP1
SOURCE GeneReport for Unigene cluster: Hs.79353
UniProtKB/Swiss-Prot: TFDP1_HUMAN, Q14186Tissue specificity: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lungand pancreas. Not detected in heart
SABiosciences Expression via Pathway-Focused PCR Array including TFDP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFDP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFDP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFDP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFDP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1 |
Orthologs
for TFDP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TFDP1 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TFDP11 |
transcription factor Dp-1 |
80.65(n)
90.49(a) |
|
418739 XM_416938.2 XP_416938.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
89(a) |
1 → many |
3(106275942-106302437) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.331422 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.57(n) |
|
CA793927.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC044409.12 |
-- |
76.81(n) |
|
BC044409.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dp3 |
dorsal/ventral axis determination,
follicular more |
58(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
dpl-13 |
transcription factor DP-1 |
52(a) |
|
II(9169866-9172120) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
DPA6DPB6 |
Transcription factor DP |
30(a)29(a) |
many ↔ manymany ↔ many |
5(542358-544900) 5(842289-845419) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 3) |
transcription factor Dp, putative, expressed(see all 3) |
33(a)30(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
10(15741606-15746558) 1(27923857-27927389) |
ENSEMBL Gene Tree for TFDP1 (if available)
TreeFam Gene Tree for TFDP1 (if available) |
Paralogs
for TFDP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TFDP1 gene
- TFDP32 TFDP22
3 SIMAP similar genes for TFDP1 using alignment to 5 protein entries: TFDP1_HUMAN (see all proteins):DKFZp434G222 TFDP2 TFDP3
TFDP1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for TFDP1
PGOHUM00000246873 PGOHUM00000245193 PGOHUM00000232901
|
Genomic Variants
for TFDP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TFDP1 (114239003 - 114295788 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TFDP1
2 CNVs: 4820 66571 | SABiosciences Cancer Mutation PCR Assays |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing TFDP1: |
|
Disorders
/ Diseases
for TFDP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TFDP1 for disorders About GeneDecksing
OMIM gene information: 189902
OMIM disorders: --
19  diseases for TFDP1: About MalaCardsnon-hodgkin lymphoma familial adenomatous polyposis esophageal squamous cell carcinoma squamous cell carcinoma
differentiating neuroblastoma hodgkin's lymphoma cytomegalovirus infection polyposis
colon carcinoma hepatocellular carcinoma embryonal carcinoma carcinoma
ovarian cancer retinoblastoma lung adenocarcinoma esophagitis
neuroblastoma adenocarcinoma breast cancer
6 Novoseek disease relationships for TFDP1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TFDP1 (2 documents)
Export disorders for TFDP1 gene to outside databases
|
Publications
for TFDP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TFDP1 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with TFDP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (PubMed id 8405995)1, 2, 9 Helin K....Harlow E. (1993)
- DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. (PubMed id 8039504)1, 2, 9 Bandara L.R....la Thangue N.B. (1994)
- Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. (PubMed id 9027491)1, 3, 9 Zhang Y....Chellappan S.P. (1997)
- Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (2002)
- In vivo association of E2F and DP family proteins. (PubMed id 7739537)1, 2 Wu C.-L.... Lees J.A. (1995)
- A new component of the transcription factor DRTF1/E2F. (PubMed id 8413592)1, 3 Girling R....La Thangue N.B. (1993)
- TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. (PubMed id 12029633)1, 9 Yasui K....Inazawa J. (2002)
- Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. (PubMed id 12607600)1, 9 Chan J.A....Brynes R.K. (2002)
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External Searches for TFDP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TFDP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TFDP1 gene
(According to HUGE)
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Specialized Databases showing TFDP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TFDP1 gene:
Search GeneIP for patents involving TFDP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TFDP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TFDP1 | | OriGene shRNA RFP for TFDP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFDP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFDP1 | | | OriGene Protein Over-expression Lysate for TFDP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TFDP1 | | OriGene 3'-UTR Clone for TFDP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFDP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TFDP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TFDP1 | | OriGene Custom Protein Services for TFDP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TFDP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFDP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFDP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFDP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFDP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFDP1 |
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| | | | Search Tocris compounds for TFDP1 |
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 | | | TFDP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFDP1 |
|  |  |  | | | | ThermoFisher Antibodies for TFDP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFDP1 |
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