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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFCP2L1 Gene

protein-coding   GIFtS: 49
GCID: GC02M121974

transcription factor CP2-like 1

 Explore 3 diseases affiliated with
TFCP2L1 via our new
 Human Malady Compendium 
Biological research products
for TFCP2L1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transcription Factor CP2-Like 11 2     Transcription Factor LBP-92 3
CRTR11 2 3 5     CRTR-12 3
LBP92 3 5     CP2-Related Transcriptional Repressor 12 3
LBP-91 2     Transcription Factor CP2-Like Protein 12

External Ids:    HGNC: 179251   Entrez Gene: 298422   Ensembl: ENSG000001151127   OMIM: 6097855   UniProtKB: Q9NZI63   

Export aliases for TFCP2L1 gene to outside databases

Previous GC identifers: GC02M122073 GC02M121694 GC02M114296


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TF2L1_HUMAN, Q9NZI6
Function: Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct
development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFCP2L1 gene promoter:
         c-Fos   E2F-1   E2F   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFCP2L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TFCP2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFCP2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14

TFCP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFCP2L1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M121974:  view genomic region     (about GC identifiers)

Start:
121,974,163 bp from pter      End:
122,042,783 bp from pter
Size:
68,621 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF2L1_HUMAN, Q9NZI6 (See protein sequence)
Recommended Name: Transcription factor CP2-like protein 1  
Size: 479 amino acids; 54627 Da
Subcellular location: Nucleus
Secondary accessions: Q4ZG43

Explore the universe of human proteins at neXtProt for TFCP2L1: NX_Q9NZI6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZI6

  • TFCP2L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055368.1  
    ENSEMBL proteins: 
     ENSP00000263707  

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    Uscn Proteins for TFCP2L1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--
    GO:0016020membrane IEA--


    TFCP2L1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TFCP2L1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007604 CP2
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q9NZI6

    ProtoNet protein and cluster: Q9NZI6

    UniProtKB/Swiss-Prot: TF2L1_HUMAN, Q9NZI6
    Similarity: Belongs to the grh/CP2 family. CP2 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TF2L1_HUMAN, Q9NZI6
    Function: Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct
    development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1

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    hsa-miR-642a hsa-miR-3194-5p hsa-miR-15a hsa-miR-519a hsa-miR-3916 hsa-miR-10b* hsa-miR-890 hsa-miR-510
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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10644752
    GO:0003714transcription corepressor activity TAS10644752
    GO:0005515protein binding ----


    TFCP2L1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TFCP2L1:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Tfcp2l1tm1.1Sjt for TFCP2L1
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfcp2l1):
     digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism  mortality/aging 
     renal/urinary system 

    TFCP2L1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TFCP2L1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/79 Interacting proteins for TFCP2L1 (Q9NZI63 ENSP000002637074) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    UBP1Q9NZI73, ENSP000002836284I2D: score=2 STRING: ENSP00000283628
    ACTL6AO960193I2D: score=1 
    AKAP8O438233I2D: score=1 
    ARID1AO144973I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000902cell morphogenesis IEA--
    GO:0002070epithelial cell maturation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10644752


    TFCP2L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFCP2L1
    Search CenterWatch for drugs/clinical trials and news about TFCP2L1 / TF2L1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFCP2L1 gene: 
    NM_014553.2  

    Unigene Cluster for TFCP2L1:

    Transcription factor CP2-like 1
    Hs.156471  [show with all ESTs]
    Unigene Representative Sequence: NM_014553
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263707(uc010flq.3 uc002tmx.3 uc010flr.3) ENST00000464621


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    hsa-miR-642a hsa-miR-3194-5p hsa-miR-15a hsa-miR-519a hsa-miR-3916 hsa-miR-10b* hsa-miR-890 hsa-miR-510
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF198488.1 AK311692.1 AL137740.1 BC020554.1 BC064698.1 

    5 DOTS entries:

    DT.91862522  DT.422508  DT.120955316  DT.95145561  DT.75103289 

    24/114 AceView cDNA sequences (see all 114):

    AI831850 BQ045123 CB242367 AI990687 BQ012939 BE674454 BE328851 BE671516 
    AA677440 BF433102 BC020554 BQ953674 AI263088 AI151375 AI453406 BE138747 
    AI609686 CK429551 AI075110 AI522077 BE327117 BU753934 AW169738 AW772315 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TFCP2L1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:              -     -                                                           -                                             
    SP2:                                                                                                                              
    SP3:                                                                                                  -                           
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for TFCP2L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFCP2L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTGTACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TFCP2L1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TFCP2L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFCP2L1

    SOURCE GeneReport for Unigene cluster: Hs.156471

    UniProtKB/Swiss-Prot: TF2L1_HUMAN, Q9NZI6
    Tissue specificity: Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic
    cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue

        SABiosciences Expression via Pathway-Focused PCR Array including TFCP2L1: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFCP2L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TFCP2L1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TFCP2L11 transcription factor CP2-like 1 80.49(n)
    90.95(a)
      424238  XM_422087.3  XP_422087.3 
    lizard
    (Anolis carolinensis)
    Reptilia TFCP2L16
    --
    90(a)
    1 ↔ 1
    1(84261220-84305089)
    African clawed frog
    (Xenopus laevis)
    Amphibia lbp-9-prov2 LBP protein; likely ortholog of mouse CRTR-1 78.5(n)    BC044100.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tfcp2l16
    transcription factor CP2-like 1
    67(a)
    1 ↔ 1
    9(39345228-39364059)
    fruit fly
    (Drosophila melanogaster)
    Insecta gem6
    gemini
    20(a)
    1 → many
    2R(6011793-6024977)


    ENSEMBL Gene Tree for TFCP2L1 (if available)
    TreeFam Gene Tree for TFCP2L1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFCP2L1 gene
    UBP12  GRHL32  GRHL12  TFCP22  GRHL22  
    3 SIMAP similar genes for TFCP2L1 using alignment to 1 protein entry:     TF2L1_HUMAN:
    DKFZp564C0164    TFCP2    UBP1

    TFCP2L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1242 NCBI SNPs in TFCP2L1 are shown (see all 1242    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914697211,2
    --121973892(+) TAGGAG/TAATCA 1 -- int10--------
    rs1112567541,2
    C,--121974033(+) CAACAA/C/GTGTGA 1 -- int13CSA WA EA 240
    rs1828205881,2
    --121974082(+) GAAGAC/TGGTAA 1 -- int10--------
    rs1164409461,2
    F,--121974372(+) CCCCGA/GCAGAT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1861602241,2
    --121974398(+) AGAAAA/GGAGTC 1 -- ut310--------
    rs1906880541,2
    --121974629(+) CCAGCA/GCTGTG 1 -- ut310--------
    rs1841786231,2
    --121974671(+) ATGAGA/GTCTGC 1 -- ut310--------
    rs43359501,2
    H,--121974699(+) GACACC/TAGGAA 1 -- ut314Minor allele frequency- T:0.00NS EA 418
    rs745067741,2
    --121974718(+) TGGCTC/TGGGCC 1 -- ut312Minor allele frequency- T:0.09CSA WA 120
    rs779378361,2
    C,--121974747(+) CTGGCC/TCCCAT 1 -- ut312Minor allele frequency- T:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for TFCP2L1 (121974163 - 122042783 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TFCP2L1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFCP2L1
    DNA2.0 Custom Variant and Variant Library Synthesis for TFCP2L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TFCP2L1 for disorders           About GeneDecksing

    OMIM gene information: 609785    OMIM disorders: --

    3 diseases for TFCP2L1:    About MalaCards
    goiter    hypothyroidism    cholesterol


    Export disorders for TFCP2L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFCP2L1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TFCP2L1)
        Utopia: connect your pdf to the dynamic
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    1. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. (PubMed id 10644752)1, 2, 3, 9 Huang N. and Miller W.L. (2000)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. CRTR-1, a developmentally regulated transcriptional r epressor related to the CP2 family of transcription factors. (PubMed id 11073954)1, 3 Rodda S....Rathjen P. (2001)
    5. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. (PubMed id 15471945)1, 9 Huang N. and Miller W.L. (2005)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation. (PubMed id 20661472)1 To S....Keough R.A. (2010)
    8. Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (2009)
    9. LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation. (PubMed id 18004979)1 Henderson Y.C....Clayman G.L. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29842 HGNC: 17925 AceView: TFCP2L1 Ensembl:ENSG00000115112 euGenes: HUgn29842
    ECgene: TFCP2L1 H-InvDB: TFCP2L1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for TFCP2L1 Pharmacogenomics, SNPs, Pathways

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    Patent Information for TFCP2L1 gene:
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