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Aliases for TFCP2L1 Gene

Aliases for TFCP2L1 Gene

  • Transcription Factor CP2-Like 1 2 3 5
  • CP2-Related Transcriptional Repressor 1 3 4
  • Transcription Factor LBP-9 3 4
  • CRTR-1 3 4
  • CRTR1 3 4
  • LBP9 3 4
  • LBP-9 3

External Ids for TFCP2L1 Gene

Previous GeneCards Identifiers for TFCP2L1 Gene

  • GC02M122073
  • GC02M121694
  • GC02M114296
  • GC02M121974

Summaries for TFCP2L1 Gene

GeneCards Summary for TFCP2L1 Gene

TFCP2L1 (Transcription Factor CP2-Like 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is UBP1.

UniProtKB/Swiss-Prot for TFCP2L1 Gene

  • Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFCP2L1 Gene

Genomics for TFCP2L1 Gene

Regulatory Elements for TFCP2L1 Gene

Promoters for TFCP2L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TFCP2L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TFCP2L1 Gene

Chromosome:
2
Start:
121,216,587 bp from pter
End:
121,285,209 bp from pter
Size:
68,623 bases
Orientation:
Minus strand

Genomic View for TFCP2L1 Gene

Genes around TFCP2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TFCP2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TFCP2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFCP2L1 Gene

Proteins for TFCP2L1 Gene

  • Protein details for TFCP2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZI6-TF2L1_HUMAN
    Recommended name:
    Transcription factor CP2-like protein 1
    Protein Accession:
    Q9NZI6
    Secondary Accessions:
    • Q4ZG43

    Protein attributes for TFCP2L1 Gene

    Size:
    479 amino acids
    Molecular mass:
    54627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TFCP2L1 Gene

Proteomics data for TFCP2L1 Gene at MOPED

Post-translational modifications for TFCP2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFCP2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TFCP2L1 Gene

Domains & Families for TFCP2L1 Gene

Protein Domains for TFCP2L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TFCP2L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZI6

UniProtKB/Swiss-Prot:

TF2L1_HUMAN :
  • Belongs to the grh/CP2 family. CP2 subfamily.
Family:
  • Belongs to the grh/CP2 family. CP2 subfamily.
genes like me logo Genes that share domains with TFCP2L1: view

No data available for Gene Families for TFCP2L1 Gene

Function for TFCP2L1 Gene

Molecular function for TFCP2L1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1.
genes like me logo Genes that share phenotypes with TFCP2L1: view

Animal Models for TFCP2L1 Gene

MGI Knock Outs for TFCP2L1:

Animal Model Products

CRISPR Products

Targeted motifs for TFCP2L1 Gene
HOMER Transcription Factor Regulatory Elements motif TFCP2L1
  • Consensus sequence: NAAACCGGTTCAAACCGGTT Submotif: canonical Cell Type: mES GEO ID: GSE11431

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and Transcription Factor Targets for TFCP2L1 Gene

Localization for TFCP2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFCP2L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFCP2L1 Gene COMPARTMENTS Subcellular localization image for TFCP2L1 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TFCP2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TFCP2L1: view

Pathways & Interactions for TFCP2L1 Gene

SuperPathways for TFCP2L1 Gene

No Data Available

Interacting Proteins for TFCP2L1 Gene

Gene Ontology (GO) - Biological Process for TFCP2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002070 epithelial cell maturation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006694 steroid biosynthetic process TAS 10644752
GO:0045927 positive regulation of growth IEA --
genes like me logo Genes that share ontologies with TFCP2L1: view

No data available for Pathways by source and SIGNOR curated interactions for TFCP2L1 Gene

Drugs & Compounds for TFCP2L1 Gene

No Compound Related Data Available

Transcripts for TFCP2L1 Gene

Unigene Clusters for TFCP2L1 Gene

Transcription factor CP2-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFCP2L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for TFCP2L1 Gene

GeneLoc Exon Structure for
TFCP2L1
ECgene alternative splicing isoforms for
TFCP2L1

Expression for TFCP2L1 Gene

mRNA expression in normal human tissues for TFCP2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFCP2L1 Gene

This gene is overexpressed in Minor Salivary Gland (x10.3), Kidney - Cortex (x8.2), Thyroid (x5.4), and Skin - Sun Exposed (Lower leg) (x5.1).

Protein differential expression in normal tissues from HIPED for TFCP2L1 Gene

This gene is overexpressed in Placenta (39.5) and Brain (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFCP2L1 Gene



SOURCE GeneReport for Unigene cluster for TFCP2L1 Gene Hs.156471

mRNA Expression by UniProt/SwissProt for TFCP2L1 Gene

Q9NZI6-TF2L1_HUMAN
Tissue specificity: Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.
genes like me logo Genes that share expression patterns with TFCP2L1: view

Protein tissue co-expression partners for TFCP2L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TFCP2L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TFCP2L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TFCP2L1 35
  • 89.84 (n)
  • 96.66 (a)
TFCP2L1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFCP2L1 35
  • 90.95 (n)
  • 96.79 (a)
TFCP2L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfcp2l1 35
  • 88.45 (n)
  • 93.53 (a)
Tfcp2l1 16
Tfcp2l1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TFCP2L1 35
  • 99.78 (n)
  • 99.78 (a)
TFCP2L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfcp2l1 35
  • 87.47 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia TFCP2L1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFCP2L1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFCP2L1 35
  • 79.23 (n)
  • 89.05 (a)
TFCP2L1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFCP2L1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9246 35
African clawed frog
(Xenopus laevis)
Amphibia lbp-9-prov 35
zebrafish
(Danio rerio)
Actinopterygii tfcp2l1 36
  • 67 (a)
OneToOne
Species with no ortholog for TFCP2L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFCP2L1 Gene

ENSEMBL:
Gene Tree for TFCP2L1 (if available)
TreeFam:
Gene Tree for TFCP2L1 (if available)

Paralogs for TFCP2L1 Gene

Paralogs for TFCP2L1 Gene

(3) SIMAP similar genes for TFCP2L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFCP2L1: view

Variants for TFCP2L1 Gene

Sequence variations from dbSNP and Humsavar for TFCP2L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs755865 -- 121,239,356(+) GGGCC(A/G)CTGTC intron-variant
rs882759 -- 121,245,497(-) GTGTT(C/T)GTCTT intron-variant
rs769001 -- 121,262,699(+) aattg(C/T)accac intron-variant
rs750413 -- 121,240,278(-) TTCCA(C/T)AGTAG intron-variant
rs750414 -- 121,240,246(-) CACAT(A/C)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFCP2L1 Gene

Variant ID Type Subtype PubMed ID
nsv874974 CNV Loss 21882294
nsv874975 CNV Loss 21882294
esv2658840 CNV Deletion 23128226
nsv525727 CNV Gain 19592680

Variation tolerance for TFCP2L1 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TFCP2L1 Gene

HapMap Linkage Disequilibrium report
TFCP2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFCP2L1 Gene

Disorders for TFCP2L1 Gene

Relevant External Links for TFCP2L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TFCP2L1

No disorders were found for TFCP2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TFCP2L1 Gene

Publications for TFCP2L1 Gene

  1. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. (PMID: 10644752) Huang N. … Miller W.L. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. (PMID: 15471945) Huang N. … Miller W.L. (Mol. Endocrinol. 2005) 3 23
  3. CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors. (PMID: 11073954) Rodda S. … Rathjen P. (J. Biol. Chem. 2001) 2 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Identification of a susceptibility locus in STAT4 for BehAset's disease in Han Chinese in a genome-wide association study. (PMID: 23001997) Hou S. … Yang P. (Arthritis Rheum. 2012) 3

Products for TFCP2L1 Gene

Sources for TFCP2L1 Gene

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