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TFCP2 Gene

protein-coding   GIFtS: 61
GCID: GC12M051488

Transcription Factor CP2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor CP21 2     LSF1D2
LSF2 3     TFCP2C2
SEF2 3     Alpha-Globin Transcription Factor CP22
SAA3 Enhancer Factor2 3     Transcription Factor LSF3
LBP1C2     

External Ids:    HGNC: 117481   Entrez Gene: 70242   Ensembl: ENSG000001354577   OMIM: 1898895   UniProtKB: Q128003   

Export aliases for TFCP2 gene to outside databases

Previous GC identifers: GC12M051655 GC12P051583 GC12M051205 GC12M049774 GC12M048519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFCP2 Gene:
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the
alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional
switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product
interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the
pathogenesis of Alzheimer's disease. (provided by RefSeq, Mar 2010)

GeneCards Summary for TFCP2 Gene:
TFCP2 (transcription factor CP2) is a protein-coding gene. Diseases associated with TFCP2 include alzheimer's disease, and neuroendocrine tumor. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is UBP1.

UniProtKB/Swiss-Prot: TFCP2_HUMAN, Q12800
Function: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1
promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1
(By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of
the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells.
Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter

Gene Wiki entry for TFCP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFCP2 gene promoter:
         E2F-3a   CREB   E2F-1   E2F   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFCP2 promoter sequence
   Search Chromatin IP Primers for TFCP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

TFCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFCP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051488:  view genomic region     (about GC identifiers)

Start:
51,487,446 bp from pter      End:
51,566,926 bp from pter
Size:
79,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TFCP2_HUMAN, Q12800 (See protein sequence)
Recommended Name: Alpha-globin transcription factor CP2  
Size: 502 amino acids; 57256 Da
Subunit: Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA.
Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By
similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and
2 copies of NFE4
Developmental stage: Expressed in fetal erythroid tissue
Miscellaneous: In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited
DNA-binding
Secondary accessions: A8K5E9 Q12801 Q9UD75 Q9UD77
Alternative splicing: 4 isoforms:  Q12800-1   Q12800-2   Q12800-3   Q12800-4   

Explore the universe of human proteins at neXtProt for TFCP2: NX_Q12800

Explore proteomics data for TFCP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys382
  • Modification sites at PhosphoSitePlus

  • See TFCP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166923.1  NP_001166924.1  NP_005644.2  

    ENSEMBL proteins: 
     ENSP00000257915   ENSP00000449742   ENSP00000447991   ENSP00000449280   ENSP00000304411  

    TFCP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TFCP2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007604 CP2
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q12800

    ProtoNet protein and cluster: Q12800

    UniProtKB/Swiss-Prot: TFCP2_HUMAN, Q12800
    Similarity: Belongs to the grh/CP2 family. CP2 subfamily


    TFCP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFCP2_HUMAN, Q12800
    Function: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1
    promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1
    (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of
    the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells.
    Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter

         Genatlas biochemistry entry for TFCP2:
    alpha-globin transcription factor,CP2,with homology to Drosophila transcription factor Elf-1/NTF-1,dimerizing with
    NFE2 to form the stage selector protein complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8157699
         
    TFCP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TFCP2:
     Decreased viability 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tfcp2):
     normal 

    TFCP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tfcp2tm1Jmc for TFCP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFCP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFCP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFCP2

    miRNA
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    miRTarBase miRNAs that target TFCP2:
    hsa-mir-331-3p (MIRT043398), hsa-mir-155-5p (MIRT020695)

    Block miRNA regulation of human, mouse, rat TFCP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFCP2 (see all 15):
    hsa-miR-3163 hsa-miR-320a hsa-miR-136 hsa-miR-323b-3p hsa-miR-499-3p hsa-miR-320d hsa-miR-105 hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidTFCP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TFCP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFCP2_HUMAN, Q12800: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    TFCP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TFCP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    2Dichloroethylene metabolism
    Dichloroethylene metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TFCP2
        Dichloroethylene metabolism

    1 BioSystems Pathway for TFCP2
        Signaling events mediated by HDAC Class I


        Pathway & Disease-focused RT2 Profiler PCR Array including TFCP2: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TFCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TFCP2 (Q128002, 3 ENSP000002579154) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147902, 3, ENSP000003512734MINT-64085 I2D: score=5 STRING: ENSP00000351273
    COILP384322, 3, ENSP000002403164MINT-2863537 I2D: score=3 STRING: ENSP00000240316
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8157699

    TFCP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFCP2

    1 Novoseek inferred chemical compound relationship for TFCP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 16.6 2 16705182 (1), 16645641 (1)



    TFCP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TFCP2 gene (3 alternative transcripts): 
    NM_001173452.1  NM_001173453.1  NM_005653.4  

    Unigene Cluster for TFCP2:

    Transcription factor CP2
    Hs.48849  [show with all ESTs]
    Unigene Representative Sequence: NM_005653
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257915(uc009zly.1) ENST00000549867 ENST00000546822 ENST00000548115
    ENST00000548108 ENST00000307660(uc001rxw.3 uc001rxv.2 uc009zlx.2)

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    Selected qRT-PCR Assays for microRNAs that regulate TFCP2 (see all 15):
    hsa-miR-3163 hsa-miR-320a hsa-miR-136 hsa-miR-323b-3p hsa-miR-499-3p hsa-miR-320d hsa-miR-105 hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidTFCP2 3' UTR sequence
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    Primer
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    Additional mRNA sequence: 

    AK291264.1 AK308087.1 BC003634.2 M84810.1 U03494.1 U03495.1 

    14 DOTS entries:

    DT.91646720  DT.453604  DT.100786025  DT.100786026  DT.95213710  DT.121125035  DT.95284597  DT.95284581 
    DT.95339757  DT.91802026  DT.92436044  DT.92436047  DT.95284580  DT.95284593 

    Selected AceView cDNA sequences (see all 382):

    CR607073 AW339486 CB147881 CR619854 AI017025 AI708513 BM990900 U03495 
    AK001839 BG678644 BM982348 BF772763 NM_005653 AL548190 R24568 BG023887 
    BU624735 BE385332 BQ002645 BC008712 AW069846 CA439769 BM821226 CB129703 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TFCP2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -                                                                           
    SP2:                          -                                                                           
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TFCP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFCP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTCTG
    TFCP2 Expression
    About this image

    TFCP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFCP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48849

    UniProtKB/Swiss-Prot: TFCP2_HUMAN, Q12800
    Tissue specificity: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung
    (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including TFCP2: 
              HIV Host Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFCP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFCP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfcp21 , 5 transcription factor CP21, 5 88.38(n)1
    96.61(a)1
      15 (56.33 cM)5
    214221  NM_033476.21  NP_258437.11 
     1005027965 
    chicken
    (Gallus gallus)
    Aves TFCP21 transcription factor CP2 79.66(n)
    95.35(a)
      378900  NM_204384.1  NP_989715.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFCP26
    transcription factor CP2
    95(a)
    1 ↔ 1
    2(67456290-67504887)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48682 Xenopus laevis transcription factor LSF (lsf) mRNA, more 80.8(n)    AY323528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc10e042 Transcribed sequence with strong similarity to protein more 80.78(n)    BM776108.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gem1 gemini 53.49(n)
    50.26(a)
      36064  NM_165750.3  NP_724895.1 


    ENSEMBL Gene Tree for TFCP2 (if available)
    TreeFam Gene Tree for TFCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFCP2 gene
    UBP12  GRHL32  GRHL12  GRHL22  TFCP2L12  
    3 SIMAP similar genes for TFCP2 using alignment to 3 protein entries:     TFCP2_HUMAN (see all proteins):
    DKFZp564C0164    TFCP2L1    UBP1

    TFCP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFCP2 (see all 1765)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114481531,2
    C--48522989(+) AATAA-/TTTTTT 3 -- int10--------
    rs74885831,2
    C--48524514(+) aaaaaA/Ttagcc 3 -- int10--------
    rs674883561,2
    C--48525528(+) AAAAA-/A/AA  
            
    GAATG
    3 -- int11NA 2
    rs113080411,2
    C--48537054(+) CTTTGT/-TTTTT 3 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs352994761,2
    C--48538807(+) GTCTC-/AAAAAA 3 -- int10--------
    rs38399871,2
    C--48544807(-) TCCAA-/AGCATT 3 -- int11Minor allele frequency- A:0.00CSA 2
    rs2005307961,2
    C--48544809(-) TTTCCA/CAAGCA 3 -- int10--------
    rs340312151,2
    C--48547422(+) AGTGA-/TTTTTT 3 -- int10--------
    rs1125229841,2
    C--48555787(+) TGGGGA/-GAAAA 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs50197651,2
    C,A,H--48555788(+) TGGGGA/GAAAAA 3 -- int1 trp34Minor allele frequency- G:0.00NA CSA 9

    HapMap Linkage Disequilibrium report for TFCP2 (51487446 - 51566926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TFCP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv703CNV Insertion18451855
    esv34039CNV Loss18971310

    Human Gene Mutation Database (HGMD): TFCP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFCP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TFCP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189889    OMIM disorders: --

    10 diseases for TFCP2:    
    About MalaCards
    alzheimer's disease    neuroendocrine tumor    down syndrome    herpes simplex
    atherosclerosis    hiv-1    ataxia    cerebritis
    hepatocellular carcinoma    malaria


    TFCP2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TFCP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 32.5 2 16710089 (1), 15860461 (1)

    Genetic Association Database (GAD): TFCP2
    Human Genome Epidemiology (HuGE) Navigator: TFCP2 (7 documents)

    Export disorders for TFCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFCP2 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with TFCP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. (PubMed id 8157699)1, 2, 3, 9 Swendeman S.L.... Sheffery M. (J. Biol. Chem. 1994)
    2. Purification and characterization of the serum amyloid A3 enhancer factor. (PubMed id 10455131)1, 2, 9 Bing Z.... Liao W.S.-L. (J. Biol. Chem. 1999)
    3. Molecular cloning of the alpha-globin transcription factor CP2. (PubMed id 1732747)1, 2, 9 Lim L.C.... Sheffery M. (Mol. Cell. Biol. 1992)
    4. Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression. (PubMed id 16710089)1, 4, 9 Schahab S....KAPlsch H. (Dement Geriatr Cogn Disord 2006)
    5. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. (PubMed id 11003662)1, 2, 9 Zhou W....Jane S.M. (Mol. Cell. Biol. 2000)
    6. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. (PubMed id 8035790)1, 2, 9 Shirra M.K.... Hansen U. (Mol. Cell. Biol. 1994)
    7. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. (PubMed id 16272261)1, 4, 9 Bertram L....Tanzi R.E. (J. Med. Genet. 2005)
    8. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. (PubMed id 7828600)1, 2, 9 Jane S.M.... Cunningham J.M. (EMBO J. 1995)
    9. No replication of genetic association between candidate polymorphisms and Alzheimer's disease. (PubMed id 19889475)1, 4 Cousin E....Campion D. (Neurobiol. Aging 2011)
    10. Cluster analysis of risk factor genetic polymorphisms in Alzheimer's disease. (PubMed id 18307033)1, 4 Randall C.N....Poduslo S.E. (Neurochem. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7024 HGNC: 11748 AceView: TFCP2 Ensembl:ENSG00000135457 euGenes: HUgn7024
    ECgene: TFCP2 H-InvDB: TFCP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TFCP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TFCP2 gene:
    Search GeneIP for patents involving TFCP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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