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Aliases for TFCP2 Gene

Aliases for TFCP2 Gene

  • Transcription Factor CP2 2 3
  • SAA3 Enhancer Factor 3 4
  • SEF 3 4
  • LSF 3 4
  • Alpha-Globin Transcription Factor CP2 3
  • Transcription Factor LSF 4
  • TFCP2C 3
  • LBP1C 3
  • LSF1D 3

External Ids for TFCP2 Gene

Previous GeneCards Identifiers for TFCP2 Gene

  • GC12M051655
  • GC12P051583
  • GC12M051205
  • GC12M049774
  • GC12M051488
  • GC12M048519

Summaries for TFCP2 Gene

Entrez Gene Summary for TFCP2 Gene

  • This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

GeneCards Summary for TFCP2 Gene

TFCP2 (Transcription Factor CP2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class I and Dichloroethylene metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is UBP1.

UniProtKB/Swiss-Prot for TFCP2 Gene

  • Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

Gene Wiki entry for TFCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFCP2 Gene

Genomics for TFCP2 Gene

Regulatory Elements for TFCP2 Gene

Genomic Location for TFCP2 Gene

Start:
51,093,663 bp from pter
End:
51,173,143 bp from pter
Size:
79,481 bases
Orientation:
Minus strand

Genomic View for TFCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFCP2 Gene

Proteins for TFCP2 Gene

  • Protein details for TFCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12800-TFCP2_HUMAN
    Recommended name:
    Alpha-globin transcription factor CP2
    Protein Accession:
    Q12800
    Secondary Accessions:
    • A8K5E9
    • Q12801
    • Q9UD75
    • Q9UD77

    Protein attributes for TFCP2 Gene

    Size:
    502 amino acids
    Molecular mass:
    57256 Da
    Quaternary structure:
    • Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.
    Miscellaneous:
    • In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding

    Alternative splice isoforms for TFCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TFCP2 Gene

Proteomics data for TFCP2 Gene at MOPED

Post-translational modifications for TFCP2 Gene

  • Ubiquitination at Lys382
  • Modification sites at PhosphoSitePlus

Other Protein References for TFCP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TFCP2 (TFCP2)

No data available for DME Specific Peptides for TFCP2 Gene

Domains for TFCP2 Gene

Protein Domains for TFCP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TFCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12800

UniProtKB/Swiss-Prot:

TFCP2_HUMAN :
  • Q12800
Family:
  • Belongs to the grh/CP2 family. CP2 subfamily.
genes like me logo Genes that share domains with TFCP2: view

No data available for Gene Families for TFCP2 Gene

Function for TFCP2 Gene

Molecular function for TFCP2 Gene

GENATLAS Biochemistry: alpha-globin transcription factor,CP2,with homology to Drosophila transcription factor Elf-1/NTF-1,dimerizing with NFE2 to form the stage selector protein complex
UniProtKB/Swiss-Prot Function: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

Gene Ontology (GO) - Molecular Function for TFCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8035790
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8157699
GO:0005515 protein binding IPI 21516116
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with TFCP2: view

Phenotypes for TFCP2 Gene

MGI mutant phenotypes for TFCP2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TFCP2:
genes like me logo Genes that share phenotypes with TFCP2: view

Animal Models for TFCP2 Gene

MGI Knock Outs for TFCP2:

Animal Model Products

CRISPR Products

miRNA for TFCP2 Gene

miRTarBase miRNAs that target TFCP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TFCP2 Gene

Localization for TFCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFCP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFCP2 Gene COMPARTMENTS Subcellular localization image for TFCP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TFCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TFCP2: view

Pathways for TFCP2 Gene

genes like me logo Genes that share pathways with TFCP2: view

Pathways by source for TFCP2 Gene

1 BioSystems pathway for TFCP2 Gene
1 GeneGo (Thomson Reuters) pathway for TFCP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • HIV Host Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for TFCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8157699
genes like me logo Genes that share ontologies with TFCP2: view

Compounds for TFCP2 Gene

(1) Novoseek inferred chemical compound relationships for TFCP2 Gene

Compound -log(P) Hits PubMed IDs
glycogen 16.6 2
genes like me logo Genes that share compounds with TFCP2: view

Transcripts for TFCP2 Gene

Unigene Clusters for TFCP2 Gene

Transcription factor CP2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TFCP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TFCP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TFCP2 Gene

GeneLoc Exon Structure for
TFCP2
ECgene alternative splicing isoforms for
TFCP2

Expression for TFCP2 Gene

mRNA expression in normal human tissues for TFCP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFCP2 Gene

SOURCE GeneReport for Unigene cluster for TFCP2 Gene Hs.48849

mRNA Expression by UniProt/SwissProt for TFCP2 Gene

Q12800-TFCP2_HUMAN
Tissue specificity: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
genes like me logo Genes that share expressions with TFCP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TFCP2 Gene

Orthologs for TFCP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFCP2 35
  • 99.67 (n)
  • 100 (a)
TFCP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFCP2 35
  • 94.2 (n)
  • 99.6 (a)
TFCP2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFCP2 35
  • 94.49 (n)
  • 99.8 (a)
TFCP2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfcp2 35
  • 88.38 (n)
  • 96.61 (a)
Tfcp2 16
Tfcp2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TFCP2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfcp2 35
  • 88.4 (n)
  • 97.18 (a)
chicken
(Gallus gallus)
Aves TFCP2 35
  • 79.66 (n)
  • 95.35 (a)
TFCP2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFCP2 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4868 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.862 35
tfcp2 35
  • 80.35 (n)
  • 93.36 (a)
zebrafish
(Danio rerio)
Actinopterygii tfcp2 35
  • 79.33 (n)
  • 90.51 (a)
tfcp2 36
  • 87 (a)
OneToOne
wufc10e04 35
fruit fly
(Drosophila melanogaster)
Insecta gem 35
  • 53.49 (n)
  • 50.26 (a)
Species with no ortholog for TFCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TFCP2 Gene

ENSEMBL:
Gene Tree for TFCP2 (if available)
TreeFam:
Gene Tree for TFCP2 (if available)

Paralogs for TFCP2 Gene

Paralogs for TFCP2 Gene

Selected SIMAP similar genes for TFCP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TFCP2: view

Variants for TFCP2 Gene

Sequence variations from dbSNP and Humsavar for TFCP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10099 -- 51,094,099(-) ATGCT(A/G)TGTTT utr-variant-3-prime
rs13463 -- 51,095,226(-) GTTTC(A/G)TGCCC utr-variant-3-prime
rs15209 -- 51,160,553(-) CTCAT(C/T)CAATC intron-variant
rs1056897 -- 51,172,758(-) AGCAG(C/T)AAGCC utr-variant-5-prime
rs1493382 -- 51,123,874(+) ACAGG(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFCP2 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
nsv703 CNV Insertion 18451855

Relevant External Links for TFCP2 Gene

HapMap Linkage Disequilibrium report
TFCP2
Human Gene Mutation Database (HGMD)
TFCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFCP2 Gene

Disorders for TFCP2 Gene

(1) Novoseek inferred disease relationships for TFCP2 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 32.5 2

Relevant External Links for TFCP2

Genetic Association Database (GAD)
TFCP2
Human Genome Epidemiology (HuGE) Navigator
TFCP2
genes like me logo Genes that share disorders with TFCP2: view

No data available for UniProtKB/Swiss-Prot for TFCP2 Gene

Publications for TFCP2 Gene

  1. Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. (PMID: 8157699) Swendeman S.L. … Sheffery M. (J. Biol. Chem. 1994) 2 3 4 23
  2. Molecular cloning of the alpha-globin transcription factor CP2. (PMID: 1732747) Lim L.C. … Sheffery M. (Mol. Cell. Biol. 1992) 3 4 23
  3. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. (PMID: 7828600) Jane S.M. … Cunningham J.M. (EMBO J. 1995) 3 4 23
  4. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. (PMID: 8035790) Shirra M.K. … Hansen U. (Mol. Cell. Biol. 1994) 3 4 23
  5. Purification and characterization of the serum amyloid A3 enhancer factor. (PMID: 10455131) Bing Z. … Liao W.S.-L. (J. Biol. Chem. 1999) 3 4 23

Products for TFCP2 Gene

Sources for TFCP2 Gene

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