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TFB2M Gene

protein-coding   GIFtS: 57
GCID: GC01M246703

Transcription Factor B2, Mitochondrial

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor B2, Mitochondrial1 2     HCV NS5A-Transactivated Protein 52 3
Hepatitis C Virus NS5A-Transactivated Protein 52 3     mtTFB22 3
Mitochondrial 12S RRNA Dimethylase 22 3     S-Adenosylmethionine-6-N', N'-Adenosyl(RRNA) Dimethyltransferase 22 3
Mitochondrial Transcription Factor B22 3     Hkp12
h-mtTFB2 3     Dimethyladenosine Transferase 2, Mitochondrial2
h-mtTFB22 3     EC 2.1.1.-3
hTFB2M2 3     NS5ATP53

External Ids:    HGNC: 185591   Entrez Gene: 642162   Ensembl: ENSG000001628517   OMIM: 6070555   UniProtKB: Q9H5Q43   

Export aliases for TFB2M gene to outside databases

Previous GC identifers: GC01M244607 GC01M241980 GC01M242800 GC01M243651 GC01M243652 GC01M243029 GC01M244770 GC01M217089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TFB2M Gene:
TFB2M (transcription factor B2, mitochondrial) is a protein-coding gene. Diseases associated with TFB2M include hepatitis c, and hepatitis c virus. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity and transcription cofactor activity.

UniProtKB/Swiss-Prot: TFB2M_HUMAN, Q9H5Q4
Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S
rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its
interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less
methyltransferase activity

Gene Wiki entry for TFB2M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFB2M gene promoter:
         Max1   E2F-3a   E2F-4   E2F-5   Sp1   E2F-2   E2F   E2F-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFB2M promoter sequence
   Search Chromatin IP Primers for TFB2M

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFB2M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

TFB2M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFB2M gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M246703:  view genomic region     (about GC identifiers)

Start:
246,703,862 bp from pter      End:
246,729,626 bp from pter
Size:
25,765 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TFB2M_HUMAN, Q9H5Q4 (See protein sequence)
Recommended Name: Dimethyladenosine transferase 2, mitochondrial precursor  
Size: 396 amino acids; 45349 Da
Subunit: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM
Sequence caution: Sequence=BAB15441.1; Type=Erroneous initiation;
Secondary accessions: Q9H626

Explore the universe of human proteins at neXtProt for TFB2M: NX_Q9H5Q4

Explore proteomics data for TFB2M at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys371
  • Modification sites at PhosphoSitePlus

  • See TFB2M Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071761.1  
    ENSEMBL proteins: 
     ENSP00000355471   ENSP00000442426  
    Reactome Protein details: Q9H5Q4

    TFB2M Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001737 rRNA_Ade_methylase_transferase
     IPR016861 Mt_di-Me-Ado_Trfase_2_prcur

    Graphical View of Domain Structure for InterPro Entry Q9H5Q4

    ProtoNet protein and cluster: Q9H5Q4

    UniProtKB/Swiss-Prot: TFB2M_HUMAN, Q9H5Q4
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine
    N(6)-methyltransferase family. KsgA subfamily


    TFB2M for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFB2M_HUMAN, Q9H5Q4
    Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S
    rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its
    interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
    Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less
    methyltransferase activity
    Induction: By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA--
    GO:0003712transcription cofactor activity IDA12068295
    GO:0003723RNA binding ----
    GO:0008649rRNA methyltransferase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    TFB2M for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TFB2M:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFB2M
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    miRNA
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    miRTarBase miRNAs that target TFB2M:
    hsa-mir-124-3p (MIRT022454), hsa-mir-26b-5p (MIRT029159)

    Block miRNA regulation of human, mouse, rat TFB2M using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TFB2M:
    hsa-miR-576-5p hsa-miR-4263 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidTFB2M 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFB2M_HUMAN, Q9H5Q4: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--
    GO:0042645mitochondrial nucleoid IDA18063578

    TFB2M for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TFB2M About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    Transcription from mitochondrial promoters0.00
    Mitochondrial transcription initiation0.00
    2Gene Expression
    Gene Expression0.40
    3Mitochondrial Gene Expression
    Mitochondrial Gene Expression
    4Energy Metabolism
    Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TFB2M
        Mitochondrial Gene Expression
    Energy Metabolism

    2 Reactome Pathways for TFB2M
        Transcriptional activation of mitochondrial biogenesis
    Mitochondrial transcription initiation



    TFB2M for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFB2M
    Interactions:

        GeneGlobe Interaction Network for TFB2M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TFB2M (Q9H5Q43 ENSP000003554714) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    TFAMQ000593, ENSP000004205884I2D: score=3 STRING: ENSP00000420588
    PNPP004913, ENSP000003545324I2D: score=1 STRING: ENSP00000354532
    ATG4CQ96DT63I2D: score=1 
    CLN3Q132863I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000154rRNA modification ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006390transcription from mitochondrial promoter TAS--
    GO:0006391transcription initiation from mitochondrial promoter TAS--
    GO:0010467gene expression TAS--

    TFB2M for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFB2M

    1 HMDB Compound for TFB2M    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TFB2M gene: 
    NM_022366.2  

    Unigene Cluster for TFB2M:

    Transcription factor B2, mitochondrial
    Hs.7395  [show with all ESTs]
    Unigene Representative Sequence: AK026835
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366514(uc001ibn.3 uc010pys.1) ENST00000544618

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TFB2M:
    hsa-miR-576-5p hsa-miR-4263 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidTFB2M 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TFB2M
      QuantiFast Probe-based Assays in human, mouse, rat TFB2M

    Additional mRNA sequence: 

    AF529366.1 AK026314.1 AK026835.1 BC003383.1 BC042010.1 

    6 DOTS entries:

    DT.95376378  DT.444130  DT.95330095  DT.92432619  DT.100773915  DT.95154287 

    Selected AceView cDNA sequences (see all 156):

    AW592237 BU733948 BM757047 AA643133 AA720622 BU631879 CB243880 AA496871 
    AA568574 BM747919 CK725134 AI093305 AA974690 AA242868 AA460334 BG940165 
    AA724431 BE302270 BU683428 AI379324 AI478439 T36250 BM725623 AA757357 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TFB2M    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                    -                                       
    SP2:                    -     -     -                           
    SP3:                                                            


    ECgene alternative splicing isoforms for TFB2M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFB2M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TFB2M Expression
    About this image

    TFB2M Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFB2M Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7395

    UniProtKB/Swiss-Prot: TFB2M_HUMAN, Q9H5Q4
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TFB2M gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfb2m1 , 5 transcription factor B2, mitochondrial1, 5 69.57(n)1
    53.33(a)1
      1 (83.56 cM)5
    152781  NM_008249.41  NP_032275.21 
     1795280555 
    chicken
    (Gallus gallus)
    Aves TFB2M1 transcription factor B2, mitochondrial 58.53(n)
    43.82(a)
      421488  XM_419535.4  XP_419535.2 
    lizard
    (Anolis carolinensis)
    Reptilia TFB2M6
    transcription factor B2, mitochondrial
    44(a)
    1 ↔ 1
    GL343534.1(39174-53142)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.167042 Transcribed sequence with weak similarity to protein more 77.06(n)    CF374635.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tfb2m1 transcription factor B2, mitochondrial 52.4(n)
    40.94(a)
      569468  NM_001113617.1  NP_001107089.1 


    ENSEMBL Gene Tree for TFB2M (if available)
    TreeFam Gene Tree for TFB2M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFB2M gene

    TFB2M for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TFB2M
    PGOHUM00000243046


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFB2M (see all 857)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348676731,2
    C--246711267(+) TTTTT-/T/T   
      T
    /TTTT
    GAGAC
    1 -- int11NA 2
    rs579986461,2
    C--246713801(+) AAAAA-/AATACAG 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs2013733521,2
    --246717817(+) GTTTT-/GCAAGGG 1 -- int10--------
    rs618523661,2
    C--246717818(+) TTTTGC/TAAGGG 1 -- int10--------
    rs1851690821,2
    C--253498835(+) CTGTCA/GCCCAG 1 -- int10--------
    rs1888115641,2
    --253498866(+) TCTCGA/GCTCAC 1 -- int10--------
    rs1468110981,2
    C--253498887(+) GCCTCC/TCAGGT 1 -- int10--------
    rs1456358031,2
    --253498943(+) GGTGCA/CCACCA 1 -- int10--------
    rs121345001,2
    C,F--253498945(+) tgcccG/Accacc 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1916048031,2
    --253498946(+) GCCCAC/TCACCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TFB2M (246703862 - 246729626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TFB2M:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5254CNV Insertion18451855
    dgv33n21CNV Gain19592680
    nsv528615CNV Gain19592680
    nsv428346CNV Gain18775914
    nsv873420CNV Gain21882294
    dgv202e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFB2M
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607055    OMIM disorders: --

    5 diseases for TFB2M:    About MalaCards
    hepatitis c    hepatitis c virus    hepatitis    parkinson's disease
    alzheimer's disease


    TFB2M for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TFB2M
    Human Genome Epidemiology (HuGE) Navigator: TFB2M (4 documents)

    Export disorders for TFB2M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFB2M gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with TFB2M)
        Utopia: connect your pdf to the dynamic
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    1. The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. (PubMed id 15526033)1, 2, 9 Gaspari M.... Gustafsson C.M. (EMBO J. 2004)
    2. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. (PubMed id 20410300)1, 2 Litonin D.... Temiakov D. (J. Biol. Chem. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease. (PubMed id 18980857)1, 4 SA!nchez-Ferrero E....Alvarez V. (amp 2009)
    5. Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy. (PubMed id 19096125)1, 4 Alonso-Montes C....Coto E. (Dis. Markers 2008)
    6. Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. (PubMed id 17031457)1, 2 Cotney J. and Shadel G.S. (J. Mol. Evol. 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. (PubMed id 15684387)1, 2 Gleyzer N.... Scarpulla R.C. (Mol. Cell. Biol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64216 HGNC: 18559 AceView: TFB2M Ensembl:ENSG00000162851 euGenes: HUgn64216
    ECgene: TFB2M H-InvDB: TFB2M

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFB2M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFB2M gene:
    Search GeneIP for patents involving TFB2M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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