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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFB1M Gene

protein-coding   GIFtS: 59
GCID: GC06M155578

Transcription Factor B1, Mitochondrial

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor B1, Mitochondrial1 2     Dimethyladenosine Transferase 1, Mitochondrial2
Mitochondrial 12S RRNA Dimethylase 12 3     Homolog Of Yeast Mitochondrial Transcription Factor B2
h-mtTFB12 3     Mitochondrial Dimethyladenosine Transferase 12
hTFB1M2 3     mtTFB2
mtTFB12 3     EC 2.1.1.-3
S-Adenosylmethionine-6-N', N'-Adenosyl(RRNA) Dimethyltransferase 12 3     h-mtTFB3
CGI752 5     Mitochondrial Transcription Factor B13
Dimethyladenosine Transferase 11     EC 2.1.18
mitochondrial1     

External Ids:    HGNC: 170371   Entrez Gene: 511062   Ensembl: ENSG000000296397   OMIM: 6070335   UniProtKB: Q8WVM03   

Export aliases for TFB1M gene to outside databases

Previous GC identifers: GC06M155054 GC06M155474 GC06M155609 GC06M155670 GC06M153141


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFB1M Gene:
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial
12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for
mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of
one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness
(AID).(provided by RefSeq, Aug 2010)

GeneCards Summary for TFB1M Gene: 
TFB1M (transcription factor B1, mitochondrial) is a protein-coding gene. Diseases associated with TFB1M include mitochondrial nonsyndromic sensorineural deafness, and mitochondrial disorders. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity and DNA binding. An important paralog of this gene is DIMT1.

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S
rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its
interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity

Gene Wiki entry for TFB1M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFB1M gene promoter:
         C/EBPbeta   POU6F1 (c2)   Meis-1b   HNF-1A   Evi-1   MEF-2A   SRY   HNF-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFB1M promoter sequence
   Search SABiosciences Chromatin IP Primers for TFB1M

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFB1M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.1-q25.3

TFB1M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFB1M gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M155578:  view genomic region     (about GC identifiers)

Start:
155,577,264 bp from pter      End:
155,635,627 bp from pter
Size:
58,364 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0 (See protein sequence)
Recommended Name: Dimethyladenosine transferase 1, mitochondrial precursor  
Size: 346 amino acids; 39543 Da
Subunit: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH05183.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q05DR0 Q9Y384

Explore the universe of human proteins at neXtProt for TFB1M: NX_Q8WVM0

Explore proteomics data for TFB1M at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVM0

  • 4/6 DME Specific Peptides for TFB1M (Q8WVM0) (see all 6)
     QNFLLDL  QKEVAER  RLPPLPTI  GPFVYGRT 

    TFB1M Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TFB1M Protein Expression
    REFSEQ proteins: NP_057104.2  
    ENSEMBL proteins: 
     ENSP00000356134  

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    Cloud-Clone Corp. Proteins for TFB1M 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0042645mitochondrial nucleoid IDA18063578

    TFB1M for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011530 rRNA_adenine_dimethylase
     IPR023165 rRNA_Ade_diMease-like
     IPR020596 rRNA_Ade_Mease_Trfase_CS
     IPR001737 rRNA_Ade_methylase_transferase
     IPR020598 rRNA_Ade_methylase_Trfase_N

    Graphical View of Domain Structure for InterPro Entry Q8WVM0

    ProtoNet protein and cluster: Q8WVM0

    1 Blocks protein domain: IPB001737 Ribosomal RNA adenine dimethylase

    UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
    Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA
    subfamily


    TFB1M for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFB1M_HUMAN, Q8WVM0
    Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S
    rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its
    interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity
    Induction: By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI12897151
    GO:0008649rRNA methyltransferase activity ----
         
    TFB1M for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfb1m):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     muscle  nervous system  vision/eye 

    TFB1M for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tfb1mtm1.2Lrsn for TFB1M

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TFB1M 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFB1M 
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    SwitchGear 3'UTR luciferase reporter plasmidTFB1M 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TFB1M About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitochondrial Gene Expression
    Mitochondrial Gene Expression
    2Energy Metabolism
    Energy Metabolism


    2 BioSystems Pathways for TFB1M
        Mitochondrial Gene Expression
    Energy Metabolism


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFB1M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/251 Interacting proteins for TFB1M (Q8WVM01, 2, 3 ENSP000003561344) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLRMTO004112, 3MINT-8079030 I2D: score=3 
    TFAMQ000591, 2, 3, ENSP000004205884EBI-2615570,EBI-1049924 MINT-8079030 I2D: score=3 STRING: ENSP00000420588
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    MRPS14O607832, ENSP000004207144MINT-8079030 STRING: ENSP00000420714
    MRPS2Q9Y3992, ENSP000002416004MINT-8079030 STRING: ENSP00000241600
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000154rRNA modification ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    TFB1M for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFB1M for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TFB1M

    1 HMDB Compound for TFB1M    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    2 Novoseek inferred chemical compound relationships for TFB1M gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rrna 58.3 4 17031457 (2), 15542390 (1)
    adenine 49.8 2 15110318 (1)

    Search CenterWatch for drugs/clinical trials and news about TFB1M

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TFB1M gene: 
    NM_016020.3  

    Unigene Cluster for TFB1M:

    Transcription factor B1, mitochondrial
    Hs.279908  [show with all ESTs]
    Unigene Representative Sequence: NM_016020
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367166(uc003qqj.4 uc003qqk.3) ENST00000468889 ENST00000470239
    ENST00000495806 ENST00000489874 ENST00000487586 ENST00000475849 ENST00000480390
    ENST00000466349
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TFB1M (see all 17):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-1260b hsa-miR-1285 hsa-miR-326 hsa-miR-1183 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidTFB1M 3' UTR sequence
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    Additional mRNA sequence: 

    AF151833.1 AK289484.1 BC005183.1 BC017788.1 BC054007.1 

    15 DOTS entries:

    DT.99928812  DT.86846782  DT.100746277  DT.121369086  DT.97839404  DT.97778447  DT.92427134  DT.121368986 
    DT.100028155  DT.92427137  DT.101976317  DT.40116452  DT.75120902  DT.91995891  DT.92018285 

    24/136 AceView cDNA sequences (see all 136):

    BM707664 AA450024 AI628397 R47388 AA405744 AI638236 AI973020 AA749175 
    BC005183 BM714985 BU849912 AA761808 CR595073 AA044637 BM559871 AW104676 
    BM676688 CA305915 BU634088 BC017788 BF196459 BU733204 BM014309 AA621573 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TFB1M    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:              -           -                     
    SP2:                          -                     
    SP3:              -                                 


    ECgene alternative splicing isoforms for TFB1M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFB1M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGTCTT
    TFB1M Expression
    About this image


    See TFB1M Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFB1M

    SOURCE GeneReport for Unigene cluster: Hs.279908

    UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TFB1M gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfb1m1 , 5 transcription factor B1, mitochondrial1, 5 85.64(n)1
    86.14(a)1
      17 (2.01 cM)5
    2244811  NM_146074.11  NP_666186.11 
     35192635 
    chicken
    (Gallus gallus)
    Aves TFB1M1 transcription factor B1, mitochondrial 72.81(n)
    74.27(a)
      428608  XM_426165.3  XP_426165.2 
    lizard
    (Anolis carolinensis)
    Reptilia TFB1M6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    1(214582674-214620446)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689242 hypothetical protein MGC68924 74.48(n)    BC056010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tfb1m1 transcription factor B1, mitochondrial 69.07(n)
    74.62(a)
      767802  NM_001076769.1  NP_001070237.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73193
    CG426301
    rRNA (adenine) methyltransferase3
    CG426301
    41(a)3
    53.03(n)1
    51.3(a)1
      68D23
    393201  NM_140242.31  NP_648499.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T03F1.71 , 3 Protein T03F1.71 43(a)3
    49.8(n)1
    44.21(a)1
      I(3855664-3859294)3
    1880221  NM_058841.51  NP_491242.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIM16
    Essential 18S rRNA dimethylase (dimethyladenosine ...
    20(a)
    1 → many
    XVI(39121-40077)


    ENSEMBL Gene Tree for TFB1M (if available)
    TreeFam Gene Tree for TFB1M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFB1M gene
    DIMT12  

    TFB1M for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1445 SNPs in TFB1M are shown (see all 1445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867521,2
    F--153188927(+) atttaC/Tatata 1 -- int10--------
    rs1833335251,2
    --153189057(+) ATAAAC/TATATA 1 -- int10--------
    rs1875112691,2
    --153189100(+) AAATTA/GTATAT 1 -- int10--------
    rs1899648801,2
    --153189132(+) AAATTA/GTATAT 1 -- int10--------
    rs1880729871,2
    --153189179(+) ATATAA/TAAATA 1 -- int10--------
    rs1925255591,2
    --153189226(+) TATATA/TTAAAT 1 -- int10--------
    rs1850086531,2
    --153189280(+) TATATA/GTATAA 1 -- int10--------
    rs1130820301,2
    C,F--155576151(+) CCAGGC/TGTGAT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1889908691,2
    --155576161(+) TCATGC/TGCACC 1 -- ds50010--------
    rs752373921,2
    C--155576222(+) GGAGGC/TGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TFB1M (155577264 - 155635627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TFB1M:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1338847CNV Deletion17803354
    nsv526576CNV Loss19592680
    nsv886790CNV Loss21882294
    nsv886789CNV Gain21882294


    Human Gene Mutation Database (HGMD): TFB1M
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TFB1M

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607033    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
  • Note=Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused
    by the A1555G mutation in the mitochondrial 12S rRNA

  • 5 diseases for TFB1M:    About MalaCards
    mitochondrial nonsyndromic sensorineural deafness    mitochondrial disorders    pneumonia    parkinson's disease
    tuberculosis


    TFB1M for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TFB1M
    Human Genome Epidemiology (HuGE) Navigator: TFB1M (5 documents)

    Export disorders for TFB1M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFB1M gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with TFB1M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. (PubMed id 11809803)1, 2, 3, 9 McCulloch V.... Shadel G.S. (2002)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Mutational screening of the Mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease. (PubMed id 18980857)1, 4, 9 Sanchez-Ferrero E....Alvarez V. (2008)
    4. Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation. (PubMed id 15110318)1, 2, 9 Bykhovskaya Y....Fischel-Ghodsian N. (2004)
    5. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. (PubMed id 15684387)1, 2, 9 Gleyzer N.... Scarpulla R.C. (2005)
    6. Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy. (PubMed id 19096125)1, 4, 9 Alonso-Montes C....Coto E. (2008)
    7. Human mitochondrial transcription factor B1 interacts with the C- terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. (PubMed id 12897151)1, 2, 9 McCulloch V. and Shadel G.S. (2003)
    8. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. (PubMed id 12496758)1, 2, 9 Seidel-Rogol B.L.... Shadel G.S. (2003)
    9. A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. (PubMed id 21195351)1, 4 Koeck T....Ling C. (2011)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51106 HGNC: 17037 AceView: TFB1M Ensembl:ENSG00000029639 euGenes: HUgn51106
    ECgene: TFB1M H-InvDB: TFB1M

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFB1M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TFB1M gene:
    Search GeneIP for patents involving TFB1M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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