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Aliases for TFAP4 Gene

Aliases for TFAP4 Gene

  • Transcription Factor AP-4 (Activating Enhancer Binding Protein 4) 2 3
  • Transcription Factor AP-4 (Activating Enhancer-Binding Protein 4) 2 3
  • Class C Basic Helix-Loop-Helix Protein 41 3 4
  • Activating Enhancer-Binding Protein 4 3 4
  • BHLHc41 3 4
  • Transcription Factor AP-4 3
  • AP-4 3

External Ids for TFAP4 Gene

Previous GeneCards Identifiers for TFAP4 Gene

  • GC16M004330
  • GC16M004307

Summaries for TFAP4 Gene

Entrez Gene Summary for TFAP4 Gene

  • Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

GeneCards Summary for TFAP4 Gene

TFAP4 (Transcription Factor AP-4 (Activating Enhancer Binding Protein 4)) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for TFAP4 Gene

  • Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5-CAGCTG-3

Gene Wiki entry for TFAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFAP4 Gene

Genomics for TFAP4 Gene

Regulatory Elements for TFAP4 Gene

Genomic Location for TFAP4 Gene

Start:
4,257,186 bp from pter
End:
4,273,075 bp from pter
Size:
15,890 bases
Orientation:
Minus strand

Genomic View for TFAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFAP4 Gene

Proteins for TFAP4 Gene

  • Protein details for TFAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01664-TFAP4_HUMAN
    Recommended name:
    Transcription factor AP-4
    Protein Accession:
    Q01664
    Secondary Accessions:
    • O60409

    Protein attributes for TFAP4 Gene

    Size:
    338 amino acids
    Molecular mass:
    38726 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Homodimer

neXtProt entry for TFAP4 Gene

Proteomics data for TFAP4 Gene at MOPED

Post-translational modifications for TFAP4 Gene

  • Ubiquitination at Lys189
  • Modification sites at PhosphoSitePlus

Other Protein References for TFAP4 Gene

No data available for DME Specific Peptides for TFAP4 Gene

Domains for TFAP4 Gene

Gene Families for TFAP4 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for TFAP4 Gene

Suggested Antigen Peptide Sequences for TFAP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q01664

UniProtKB/Swiss-Prot:

TFAP4_HUMAN :
  • Q01664
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TFAP4: view

Function for TFAP4 Gene

Molecular function for TFAP4 Gene

GENATLAS Biochemistry: transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of integral membrane proteins
UniProtKB/Swiss-Prot Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5-CAGCTG-3

Gene Ontology (GO) - Molecular Function for TFAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding IDA 9931457
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA 2833704
GO:0003713 NOT transcription coactivator activity IDA 11171123
genes like me logo Genes that share ontologies with TFAP4: view

Phenotypes for TFAP4 Gene

genes like me logo Genes that share phenotypes with TFAP4: view

Animal Models for TFAP4 Gene

MGI Knock Outs for TFAP4:

Transcription Factor Targeting for TFAP4 Gene

Selected GeneGlobe predicted Target genes for TFAP4
Targeting motifs for TFAP4 Gene
HOMER Transcription Factor Regulatory Elements motif TFAP4
  • Consensus sequence: NAHCAGCTGD Submotif: canonical Cell Type: AML GeoId: GSE45738

No data available for Enzyme Numbers (IUBMB) for TFAP4 Gene

Localization for TFAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFAP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFAP4 Gene COMPARTMENTS Subcellular localization image for TFAP4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TFAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11171123
GO:0017053 transcriptional repressor complex ISS --
genes like me logo Genes that share ontologies with TFAP4: view

Pathways for TFAP4 Gene

SuperPathways for TFAP4 Gene

Superpath Contained pathways
1 Proteoglycans in cancer
genes like me logo Genes that share pathways with TFAP4: view

Pathways by source for TFAP4 Gene

1 KEGG pathway for TFAP4 Gene

Gene Ontology (GO) - Biological Process for TFAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IDA 2833704
GO:0006461 protein complex assembly IDA 19505873
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 18818310
GO:0008285 negative regulation of cell proliferation IMP 18818310
genes like me logo Genes that share ontologies with TFAP4: view

Compounds for TFAP4 Gene

(1) Novoseek inferred chemical compound relationships for TFAP4 Gene

Compound -log(P) Hits PubMed IDs
leucine 35.6 1
genes like me logo Genes that share compounds with TFAP4: view

Transcripts for TFAP4 Gene

Unigene Clusters for TFAP4 Gene

Transcription factor AP-4 (activating enhancer binding protein 4):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFAP4 Gene

No ASD Table

Relevant External Links for TFAP4 Gene

GeneLoc Exon Structure for
TFAP4
ECgene alternative splicing isoforms for
TFAP4

Expression for TFAP4 Gene

mRNA expression in normal human tissues for TFAP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFAP4 Gene

SOURCE GeneReport for Unigene cluster for TFAP4 Gene Hs.513305

genes like me logo Genes that share expressions with TFAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TFAP4 Gene

Orthologs for TFAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TFAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFAP4 35
  • 97.93 (n)
  • 97.33 (a)
TFAP4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFAP4 35
  • 93.83 (n)
  • 95.82 (a)
TFAP4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFAP4 35
  • 93.87 (n)
  • 97.33 (a)
TFAP4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfap4 35
  • 91.12 (n)
  • 97.63 (a)
Tfap4 16
Tfap4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TFAP4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFAP4 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfap4 35
  • 90.83 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves TFAP4 35
  • 85.5 (n)
  • 91.44 (a)
TFAP4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFAP4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfap4 35
  • 73.13 (n)
  • 80.61 (a)
zebrafish
(Danio rerio)
Actinopterygii tfap4 35
  • 75.73 (n)
  • 77.81 (a)
tfap4 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta crp 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-11 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2164 36
  • 20 (a)
OneToOne
Species with no ortholog for TFAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFAP4 Gene

ENSEMBL:
Gene Tree for TFAP4 (if available)
TreeFam:
Gene Tree for TFAP4 (if available)

Paralogs for TFAP4 Gene

Selected SIMAP similar genes for TFAP4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TFAP4: view

No data available for Paralogs for TFAP4 Gene

Variants for TFAP4 Gene

Sequence variations from dbSNP and Humsavar for TFAP4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs251730 -- 4,260,894(+) GGAGA(A/T)GCCGT intron-variant
rs251731 -- 4,260,708(+) GCCCC(C/T)CTCAA intron-variant
rs251732 - 4,260,467(+) CGCAG(C/G)TGCTG missense, reference
rs251733 -- 4,271,604(+) CTAGG(A/T)CCAAA intron-variant
rs251734 -- 4,271,440(+) CGTAG(A/G)ACGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFAP4 Gene

Variant ID Type Subtype PubMed ID
esv21490 CNV Gain+Loss 19812545
nsv527866 CNV Loss 19592680
nsv905222 CNV Loss 21882294
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
nsv827529 CNV Gain 20364138

Relevant External Links for TFAP4 Gene

HapMap Linkage Disequilibrium report
TFAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TFAP4 Gene

Disorders for TFAP4 Gene

Relevant External Links for TFAP4

Genetic Association Database (GAD)
TFAP4
Human Genome Epidemiology (HuGE) Navigator
TFAP4
genes like me logo Genes that share disorders with TFAP4: view

No data available for UniProtKB/Swiss-Prot for TFAP4 Gene

Publications for TFAP4 Gene

  1. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PMID: 2123466) Hu Y.-F. … Tjian R. (Genes Dev. 1990) 2 3 4 23
  2. Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PMID: 7933101) Ou S.H. … Gaynor R.B. (J. Virol. 1994) 3 4 23
  3. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. (PMID: 10438607) King-Jones K. … Lehmann M. (J. Mol. Biol. 1999) 3 23
  4. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. (PMID: 11171123) Aranburu A. … Leanderson T. (Biochem. J. 2001) 3 23
  5. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PMID: 19505873) Ku W.C. … Chen Y.J. (Mol. Cell Proteomics 2009) 3 23

Products for TFAP4 Gene

  • Addgene plasmids for TFAP4

Sources for TFAP4 Gene

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