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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFAP4 Gene

protein-coding   GIFtS: 55
GCID: GC16M004307

transcription factor AP-4 (activating enhancer binding protein...

(Previous name: transcription factor AP-4 (activating enhancer-binding...)
 Explore 5 diseases affiliated with
TFAP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TFAP4    

Aliases
for TFAP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transcription Factor AP-4 (Activating Enhancer Binding Protein 4)1 2     Activating Enhancer-Binding Protein 42 3
BHLHc411     Class C Basic Helix-Loop-Helix Protein 412 3
AP-41 2     Transcription Factor AP-42
Transcription Factor AP-4 (Activating Enhancer-Binding Protein 4)1 2     BHLHC413

External Ids:    HGNC: 117451   Entrez Gene: 70232   Ensembl: ENSG000000904477   OMIM: 6007435   UniProtKB: Q016643   
ORGUL members:         
NONCODE:n339058    

Export aliases for TFAP4 gene to outside databases

Previous GC identifers: GC16M004330 GC16M004247


Summaries
for TFAP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TFAP4:
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for
DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both
viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed 2833704); Hu
et al., 1990 (PubMed 2123466)).(supplied by OMIM, Jul 2009)

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664
Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence
5'-CAGCTG-3'

Gene Wiki entry for TFAP4


Genomic Views
for TFAP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFAP4 gene promoter:
         TBP   CREB   NF-1   NF-1/L   p53   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TFAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TFAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13

TFAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004307:  view genomic region     (about GC identifiers)

Start:
 4,307,187 bp from pter      End:
 4,323,076 bp from pter
Size:
 15,890 bases      Orientation:
 minus strand

Proteins
for TFAP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664 (See protein sequence)
Recommended Name: Transcription factor AP-4  
Size: 338 amino acids; 38726 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer
Subcellular location: Nucleus
Secondary accessions: O60409

Explore the universe of human proteins at neXtProt for TFAP4: NX_Q01664

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01664

    • TFAP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003214.1  
    ENSEMBL proteins: 
     ENSP00000204517   ENSP00000461352   ENSP00000460067   ENSP00000459390  

    Human Recombinant Protein Products: 
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    Novus Biologicals TFAP4 Proteins
    Novus Biologicals TFAP4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TFAP4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9931457
    GO:0017053transcriptional repressor complex ISS--


    TFAP4 for ontologies           About GeneDecksing



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    Uscn Antibodies for TFAP4
    ThermoFisher Antibody for TFAP4

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    Uscn ELISAs and CLIAs for TFAP4

    Protein Domains /
    Families
    for TFAP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TFAP4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q01664

    ProtoNet protein and cluster: Q01664

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for TFAP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664
    Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence
    5'-CAGCTG-3'

         Genatlas biochemistry entry for TFAP4:
    transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of integral
    membrane proteins

    10/869 SABiosciences Target genes for TFAP4 (see all 869):
    ABCA7 ACAD9 ACAP2 ACP6 ACPT ACSL3 ACSM5 ACTG1 ADH5 ADORA1

    miRNA
    Products:            		miRTarBase miRNAs that target TFAP4:
    hsa-mir-373 (MIRT002538)

    OriGene 3'-UTR Clone: TFAP4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFAP4
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TFAP4 (see all 46):
    hsa-miR-4254 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-548k hsa-miR-15a hsa-miR-16-1* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: TFAP4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFAP4 (see all 4)
    OriGene shRNA RFP: TFAP4
    OriGene siRNA: TFAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFAP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TFAP4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: TFAP4 (NM_003223)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TFAP4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP4

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA9931457
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA2833704
    GO:0003713NOT transcription coactivator activity IDA11171123
    GO:0005515protein binding IPI19505873
    GO:0042803protein homodimerization activity IPI2123466


    TFAP4 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TFAP4:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Tfap4tm1.1Litt for TFAP4
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tfap4):
     cellular  hematopoietic system  immune system  mortality/aging 

    TFAP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TFAP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for TFAP4 (Q016643 ENSP000002045174) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    KIAA1279Q96EK53I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly IDA19505873
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA18818310
    GO:0007090regulation of S phase of mitotic cell cycle IDA18818310
    GO:0008285negative regulation of cell proliferation IMP18818310
    GO:0010629negative regulation of gene expression ----


    TFAP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TFAP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFAP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFAP4
    1 Novoseek chemical compound relationship for TFAP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.6 1 2123466 (1)

    Search CenterWatch for drugs/clinical trials and news about TFAP4 

    Transcripts
    for TFAP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TFAP4 gene: 
    NM_003223.2  

    Unigene Cluster for TFAP4:

    Transcription factor AP-4 (activating enhancer binding protein 4)
    Hs.513305  [show with all ESTs]
    Unigene Representative Sequence: S73885
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575672 ENST00000204517(uc010uxg.2) ENST00000575320 ENST00000574639
    ENST00000573476 ENST00000575300 ENST00000572393

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TFAP4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TFAP4
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TFAP4 (see all 46):
    hsa-miR-4254 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-548k hsa-miR-15a hsa-miR-16-1* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: TFAP4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFAP4 (see all 4)
    OriGene shRNA RFP: TFAP4
    OriGene siRNA: TFAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFAP4
    Clone
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFAP4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFAP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFAP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFAP4

    Additional cDNA sequence: 

    BC010576.1 CR541726.1 S73885.1 X57435.1 

    6 DOTS entries:

    DT.455041  DT.100720185  DT.95107157  DT.100810845  DT.100763870  DT.91983108 

    24/73 AceView cDNA sequences (see all 73):

    BQ441928 BM450579 BU159415 BC039696 AL527330 CR541726 CR605422 BC010576 
    BQ216830 CR610803 BE254143 BF516246 BX354642 BX389541 BX357531 BX112687 
    AA679578 BU171481 X57435 BI766776 BM755885 BX416767 CA314763 BE018236 

    GeneLoc Exon Structure


    Expression
    for TFAP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTGGGGGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TFAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFAP4

    SOURCE GeneReport for Unigene cluster: Hs.513305
        SABiosciences Custom PCR Arrays for TFAP4
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    In Situ
    Assay Products:     
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    Orthologs
    for TFAP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TFAP4 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tfap41 , 5 transcription factor AP41, 5 91.12(n)1
    97.63(a)1    		   16 (2.45 cM)5
    833831  NM_031182.21  NP_112459.11 
     45446615 
    chicken
    (Gallus gallus)    		 Aves TFAP41 transcription factor AP-4 (activating enhancer binding more 86.73(n)
    93.88(a)    		   430233  XM_427787.3  XP_427787.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TFAP46
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343856.1(60345-67502)
    zebrafish
    (Danio rerio)    		 Actinopterygii tfap41 transcription factor AP-4 (activating enhancer binding more 77.88(n)
    82.39(a)    		   100318080  XM_002667567.2  XP_002667613.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta crp6
    		 cropped
    		 17(a)
    		 1 ↔ 1
    		 2L(16264061-16287728)
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-116
    		 Helix-loop-helix protein 11
    		 19(a)
    		 1 ↔ 1
    		 III(9622060-9626453)


    ENSEMBL Gene Tree for TFAP4 (if available)
    TreeFam Gene Tree for TFAP4 (if available) 

    Paralogs
    for TFAP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TFAP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in TFAP4 are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1126424221,2
    		C,--4306785(+) CCCCTC/TCTAGG 1 -- ds50013Minor allele frequency- T:0.21CSA WA NA 239
    rs735032761,2
    		C,--4306917(+) GGAATC/TGGTGG 1 -- ds50013Minor allele frequency- T:0.05WA NA 240
    rs133366271,2
    		H--4307053(+) ACACCA/CCACAC 1 -- ds50014Minor allele frequency- C:0.00NS EA 418
    rs1867941581,2
    		--4307162(+) GGCCAA/GCCCAC 1 -- ds50010--------
    rs2008512211,2
    		--4307181(+) GACTC-/AGAATCT 1 -- ds50010--------
    rs1914413061,2
    		--4307235(+) ACGGTA/GGCCTC 1 -- ut310--------
    rs121496501,2
    		H--4307258(+) TCCCCA/CCTTTC 1 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs346345331,2
    		C--4307313(+) ATTGT-/AAAAAA 1 -- ut312Minor allele frequency- A:0.25NA CSA 4
    rs1451633851,2
    		C,--4307359(+) AAAAA-/CAGAA 
    AGCAAACC    AAAAA     		1 -- ut310--------
    rs755600231,2
    		F,--4307404(+) CAAAAC/GAAAAA 1 -- ut311Minor allele frequency- G:0.05EA 120

    HapMap Linkage Disequilibrium report for TFAP4 (4307187 - 4323076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TFAP4
         1 CNV: 72431

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for TFAP4

    Disorders / Diseases
    for TFAP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TFAP4 for disorders           About GeneDecksing

    OMIM gene information: 600743    OMIM disorders: --

    5 diseases for TFAP4:    About MalaCards
    colorectal cancer    prostate cancer    breast cancer    prostatitis
    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: TFAP4 (1 document)

    Export disorders for TFAP4 gene to outside databases

    Publications
    for TFAP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFAP4 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with TFAP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PubMed id 2123466)1, 2, 3, 9 Hu Y.-F.... Tjian R. (1990)
    2. Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PubMed id 7933101)1, 2, 9 Ou S.H.... Gaynor R.B. (1994)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1, 9 Ku W.C....Chen Y.J. (2009)
    7. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. (PubMed id 11171123)1, 9 Aranburu A....Leanderson T. (2001)
    8. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. (PubMed id 10438607)1, 9 King-Jones K....Lehmann M. (1999)
    9. Down-regulation of AP-4 inhibits proliferation, induce s cell cycle arrest and promotes apoptosis in human gastric cancer cells. (PubMed id 22615908)1 Liu X....Chen J. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for TFAP4 gene

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    Genome Databases showing TFAP4 gene

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    Entrez Gene: 7023 HGNC: 11745 AceView: TFAP4 Ensembl:ENSG00000090447 euGenes: HUgn7023
    ECgene: TFAP4 H-InvDB: TFAP4

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    Specialized Databases showing TFAP4 gene

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    PharmGKB entry for TFAP4 Pharmacogenomics, SNPs, Pathways

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