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TFAP4 Gene

protein-coding   GIFtS: 62
GCID: GC16M004307

Transcription Factor AP-4 (Activating Enhancer Binding Protein...

(Previous name: transcription factor AP-4 (activating enhancer-binding protein...)
  Search for TFAP4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transcription Factor AP-4 (Activating Enhancer Binding Protein 4)1 2     bHLHc412 3
Transcription Factor AP-4 (Activating Enhancer-Binding Protein 4)1 2     AP-42
Activating Enhancer-Binding Protein 42 3     Transcription Factor AP-42
Class C Basic Helix-Loop-Helix Protein 412 3     BHLHC413

External Ids:    HGNC: 117451   Entrez Gene: 70232   Ensembl: ENSG000000904477   OMIM: 6007435   UniProtKB: Q016643   
ORGUL members:         

Export aliases for TFAP4 gene to outside databases

Previous GC identifers: GC16M004330 GC16M004247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TFAP4 Gene:
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used
for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates
both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed
2833704); Hu et al., 1990 (PubMed 2123466)).(supplied by OMIM, Jul 2009)

GeneCards Summary for TFAP4 Gene:
TFAP4 (transcription factor AP-4 (activating enhancer binding protein 4)) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664
Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA
sequence 5'-CAGCTG-3'

Gene Wiki entry for TFAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFAP4 gene promoter:
         TBP   CREB   NF-1   NF-1/L   p53   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFAP4 promoter sequence
   Search Chromatin IP Primers for TFAP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13

TFAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004307:  view genomic region     (about GC identifiers)

Start:
4,307,187 bp from pter      End:
4,323,076 bp from pter
Size:
15,890 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664 (See protein sequence)
Recommended Name: Transcription factor AP-4  
Size: 338 amino acids; 38726 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer
Secondary accessions: O60409

Explore the universe of human proteins at neXtProt for TFAP4: NX_Q01664

Explore proteomics data for TFAP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys189
  • Modification sites at PhosphoSitePlus

  • See TFAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003214.1  
    ENSEMBL proteins: 
     ENSP00000204517   ENSP00000461352   ENSP00000460067   ENSP00000459390  

    TFAP4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q01664

    ProtoNet protein and cluster: Q01664

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with TFAP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFAP4_HUMAN, Q01664
    Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA
    sequence 5'-CAGCTG-3'

         Genatlas biochemistry entry for TFAP4:
    transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of
    integral membrane proteins

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding IDA9931457
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA2833704
    GO:0003713NOT transcription coactivator activity IDA11171123
         
    Find genes that share ontologies with TFAP4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TFAP4:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tfap4):
     hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with TFAP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tfap4tm1.1Litt for TFAP4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFAP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFAP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFAP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFAP4

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for TFAP4 (see all 829):
    ABCA7,  ACAD9,  ACAP2,  ACP6,  ACPT,  ACSL3,  ACSM5,  ACTG1,  ADH5,  ADORA1

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NAHCAGCTGD 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TFAP4:
    hsa-mir-124-3p (MIRT022725), hsa-mir-16-5p (MIRT031768), hsa-mir-101-3p (MIRT027354), hsa-mir-335-5p (MIRT018094), hsa-mir-373-3p (MIRT002538)

    Block miRNA regulation of human, mouse, rat TFAP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP4 (see all 46):
    hsa-miR-4254 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-548k hsa-miR-15a hsa-miR-16-1* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidTFAP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TFAP4

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFAP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP4
    Addgene plasmids for TFAP4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TFAP4_HUMAN, Q01664: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11171123
    GO:0017053transcriptional repressor complex ISS--

    Find genes that share ontologies with TFAP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TFAP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Proteoglycans in cancer
    Proteoglycans in cancer


    Find genes that share SuperPaths with TFAP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TFAP4):
        Proteoglycans in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFAP4
    Interactions:

        GeneGlobe Interaction Network for TFAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TFAP4 (Q016643 ENSP000002045174) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    KIAA1279Q96EK53I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter IDA2833704
    GO:0006461protein complex assembly IDA19505873
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA18818310
    GO:0008285negative regulation of cell proliferation IMP18818310
    GO:0010629negative regulation of gene expression ----

    Find genes that share ontologies with TFAP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFAP4

    1 Novoseek inferred chemical compound relationship for TFAP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.6 1 2123466 (1)



    Find genes that share compounds with TFAP4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TFAP4 gene: 
    NM_003223.2  

    Unigene Cluster for TFAP4:

    Transcription factor AP-4 (activating enhancer binding protein 4)
    Hs.513305  [show with all ESTs]
    Unigene Representative Sequence: S73885
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575672 ENST00000204517(uc010uxg.2) ENST00000575320 ENST00000574639
    ENST00000573476 ENST00000575300 ENST00000572393
    miRNA
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    Block miRNA regulation of human, mouse, rat TFAP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP4 (see all 46):
    hsa-miR-4254 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-548k hsa-miR-15a hsa-miR-16-1* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidTFAP4 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for TFAP4 
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    OriGene qPCR primer pairs and template standards for TFAP4
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      QuantiTect SYBR Green Assays in human, mouse, rat TFAP4
      QuantiFast Probe-based Assays in human, mouse, rat TFAP4

    Additional mRNA sequence: 

    BC010576.1 CR541726.1 S73885.1 X57435.1 

    6 DOTS entries:

    DT.455041  DT.100720185  DT.95107157  DT.100810845  DT.100763870  DT.91983108 

    Selected AceView cDNA sequences (see all 73):

    CR610803 CR541726 BQ441928 BQ216830 BM450579 BC010576 BE254143 CR605422 
    AL527330 BU159415 BC039696 BX112687 BF516246 BU172406 BM755885 BU171481 
    BX354642 BI766776 AL529961 AA679578 BV198722 X57435 AA314453 BX357531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGGGGTA
    TFAP4 Expression
    About this image

    TFAP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFAP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513305
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFAP4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfap41 , 5 transcription factor AP41, 5 91.12(n)1
    97.63(a)1
      16 (2.45 cM)5
    833831  NM_031182.21  NP_112459.11 
     45446615 
    chicken
    (Gallus gallus)
    Aves TFAP41 transcription factor AP-4 (activating enhancer binding more 85.5(n)
    91.44(a)
      430233  XM_427787.4  XP_427787.4 
    lizard
    (Anolis carolinensis)
    Reptilia TFAP46
    transcription factor AP-4 (activating enhancer bin...
    79(a)
    1 ↔ 1
    GL343856.1(60058-68964)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tfap41 transcription factor AP-4 (activating enhancer binding more 73.13(n)
    80.61(a)
      100170601  NM_001130369.1  NP_001123841.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tfap41 transcription factor AP-4 (activating enhancer binding more 75.73(n)
    77.81(a)
      100318080  XM_005168469.1  XP_005168526.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta crp6
    cropped
    20(a)
    1 ↔ 1
    2L(16264061-16287728)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-116
    Protein HLH-11, isoform d (hlh-11) mRNA, complete ...
    22(a)
    1 ↔ 1
    III(9622147-9626537) WBGene00001955


    ENSEMBL Gene Tree for TFAP4 (if available)
    TreeFam Gene Tree for TFAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFAP4 gene
    1 SIMAP similar gene for TFAP4 using alignment to 5 protein entries:     TFAP4_HUMAN (see all proteins):
    MAX

    Find genes that share paralogs with TFAP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFAP4 (see all 519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918878991,2
    --4259196(+) GAGCCA/TCTCCG 1 -- int10--------
    rs1828080051,2
    --4259275(+) TAACTC/TGGGGC 1 -- int10--------
    rs1497660601,2
    --4259410(+) GCCGCA/CCTAGG 1 -- int10--------
    rs37475691,2
    C,F--4259520(+) GCTGCC/TGGGTC 1 -- int1 tfbs32Minor allele frequency- T:0.04EA 1604
    rs47864791,2
    --4259567(+) CGGGCC/TGAAGG 1 -- int10--------
    rs1922219291,2
    C--4259589(+) CATTCA/GTAACA 1 -- int10--------
    rs37475701,2
    C,H--4259610(+) GGGACC/TTGCCC 1 -- int1 tfbs37Minor allele frequency- T:0.41NS EA WA NA 766
    rs37475711,2
    C,F,A,H--4259626(+) CCAGGG/ATGCGC 1 -- int19Minor allele frequency- A:0.40NA WA CSA EA 370
    rs1837128101,2
    --4259653(+) ACGACC/TTGGGG 1 -- int10--------
    rs796375221,2
    --4259867(+) AATAGC/TTACTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TFAP4 (4307187 - 4323076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TFAP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905222CNV Loss21882294
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905223CNV Loss21882294
    nsv827529CNV Gain20364138
    esv21490CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFAP4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600743    OMIM disorders: --


    Find genes that share disorders with TFAP4           About GenesLikeMe

    Genetic Association Database (GAD): TFAP4
    Human Genome Epidemiology (HuGE) Navigator: TFAP4 (1 document)

    Export disorders for TFAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFAP4 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with TFAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PubMed id 2123466)1, 2, 3, 9 Hu Y.-F.... Tjian R. (Genes Dev. 1990)
    2. Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PubMed id 7933101)1, 2, 9 Ou S.H.... Gaynor R.B. (J. Virol. 1994)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PubMed id 19505873)1, 9 Ku W.C....Chen Y.J. (amp 2009)
    7. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. (PubMed id 11171123)1, 9 Aranburu A....Leanderson T. (Biochem. J. 2001)
    8. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. (PubMed id 10438607)1, 9 King-Jones K....Lehmann M. (J. Mol. Biol. 1999)
    9. AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. (PubMed id 23752226)1 Jackstadt R....Hermeking H. (J. Exp. Med. 2013)
    10. AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation. (PubMed id 23949224)1 Jackstadt R....Hermeking H. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7023 HGNC: 11745 AceView: TFAP4 Ensembl:ENSG00000090447 euGenes: HUgn7023
    ECgene: TFAP4 Kegg: 7023 H-InvDB: TFAP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFAP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFAP4 gene:
    Search GeneIP for patents involving TFAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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