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TFAP2E Gene

protein-coding   GIFtS: 46
GCID: GC01P036038

Transcription Factor AP-2 Epsilon (Activating Enhancer Binding...

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor AP-2 Epsilon (Activating Enhancer Binding Protein
2 Epsilon)1 2
Activating Enhancer-Binding Protein 2-Epsilon2 3
AP2-epsilon2 3
AP2E2
Adaptor-Related Protein Complex 2, Epsilon Subunit2
Transcription Factor AP-2-Epsilon2

External Ids:    HGNC: 307741   Entrez Gene: 3394882   Ensembl: ENSG000001168197   OMIM: 6144285   UniProtKB: Q6VUC03   

Export aliases for TFAP2E gene to outside databases

Previous GC identifers: GC00U920631 GC01P035709 GC01P035811 GC01P034157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TFAP2E Gene:
TFAP2E (transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)) is a protein-coding gene. Diseases associated with TFAP2E include colorectal cancer. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TFAP2C.

UniProtKB/Swiss-Prot: AP2E_HUMAN, Q6VUC0
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements
to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and
activate genes involved in a large spectrum of important biological functions including proper eye, face, body
wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha
and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFAP2E gene promoter:
         GR   GR-beta   CUTL1   MIF-1   E4BP4   GATA-2   HEN1   Ik-2   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFAP2E promoter sequence
   Search Chromatin IP Primers for TFAP2E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFAP2E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

TFAP2E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP2E gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036038:  view genomic region     (about GC identifiers)

Start:
36,038,971 bp from pter      End:
36,060,929 bp from pter
Size:
21,959 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AP2E_HUMAN, Q6VUC0 (See protein sequence)
Recommended Name: Transcription factor AP-2-epsilon  
Size: 442 amino acids; 46212 Da
Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity)
Sequence caution: Sequence=AAH41175.1; Type=Erroneous initiation; Sequence=EAX07409.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q8IW12

Explore the universe of human proteins at neXtProt for TFAP2E: NX_Q6VUC0

Explore proteomics data for TFAP2E at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TFAP2E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848643.2  
    ENSEMBL proteins: 
     ENSP00000362332  

    TFAP2E Human Recombinant Protein Products:

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    OriGene Custom Protein Services for TFAP2E
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    Novus Biologicals TFAP2E Protein
    Novus Biologicals TFAP2E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TFAP2E Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TFAP2E (AP-2 epsilon)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TFAP2E
    Novus Biologicals TFAP2E Antibody
    Abcam antibodies for TFAP2E
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TFAP2E
    LSBio Antibodies in human, mouse, rat for TFAP2E

    TFAP2E Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004979 TF_AP2
     IPR013854 TF_AP2_C

    Graphical View of Domain Structure for InterPro Entry Q6VUC0

    ProtoNet protein and cluster: Q6VUC0

    1 Blocks protein domain: IPB004979 Transcription factor AP-2 signature

    UniProtKB/Swiss-Prot: AP2E_HUMAN, Q6VUC0
    Similarity: Belongs to the AP-2 family


    TFAP2E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP2E_HUMAN, Q6VUC0
    Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements
    to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and
    activate genes involved in a large spectrum of important biological functions including proper eye, face, body
    wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha
    and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TFAP2E for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfap2e):
     nervous system  taste/olfaction 

    TFAP2E for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFAP2E
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFAP2E

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFAP2E
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFAP2E

    miRNA
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    Block miRNA regulation of human, mouse, rat TFAP2E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP2E (see all 20):
    hsa-miR-148b* hsa-miR-607 hsa-miR-1197 hsa-miR-25 hsa-miR-218 hsa-miR-1297 hsa-miR-3116 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidTFAP2E 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TFAP2E
    Predesigned siRNA for gene silencing in human, mouse, rat TFAP2E

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TFAP2E

    Clone
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    OriGene clones in human, mouse for TFAP2E (see all 9)
    OriGene ORF clones in mouse, rat for TFAP2E
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFAP2E (NM_178548)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFAP2E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2E

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TFAP2E 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2E


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP2E_HUMAN, Q6VUC0: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TFAP2E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFAP2E
    Interactions:

        Search GeneGlobe Interaction Network for TFAP2E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TFAP2E (Q6VUC03 ENSP000003623324) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFAP2AP055493I2D: score=1 
    TFAP2BQ924813I2D: score=1 
    TFAP2CQ927543I2D: score=1 
    TFAP2DENSP000000083914STRING: ENSP00000008391
    C9orf41ENSP000003660304STRING: ENSP00000366030
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    TFAP2E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFAP2E (AP2E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TFAP2E gene: 
    NM_178548.3  

    Unigene Cluster for TFAP2E:

    Transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
    Hs.567844  [show with all ESTs]
    Unigene Representative Sequence: AY326454
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373235(uc010ohy.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TFAP2E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP2E (see all 20):
    hsa-miR-148b* hsa-miR-607 hsa-miR-1197 hsa-miR-25 hsa-miR-218 hsa-miR-1297 hsa-miR-3116 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidTFAP2E 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TFAP2E
    Predesigned siRNA for gene silencing in human, mouse, rat TFAP2E
    Clone
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    OriGene clones in human, mouse for TFAP2E (see all 9)
    OriGene ORF clones in mouse, rat for TFAP2E
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFAP2E (NM_178548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFAP2E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2E
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TFAP2E
    OriGene qSTAR qPCR primer pairs in human, mouse for TFAP2E
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFAP2E
      QuantiTect SYBR Green Assays in human, mouse, rat TFAP2E
      QuantiFast Probe-based Assays in human, mouse, rat TFAP2E

    Additional mRNA sequence: 

    AY326454.1 BC041175.1 BC150147.1 

    2 DOTS entries:

    DT.97800372  DT.75100293 

    4 AceView cDNA sequences:

    BC041175 AY326454 NM_178548 BQ219020 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFAP2E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGAGCC
    TFAP2E Expression
    About this image


    TFAP2E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Medulla Oblongata
    TFAP2E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFAP2E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567844

    UniProtKB/Swiss-Prot: AP2E_HUMAN, Q6VUC0
    Tissue specificity: Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line

        Custom PCR Arrays for TFAP2E
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFAP2E gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfap2e1 , 5 transcription factor AP-2, epsilon1, 5 87.48(n)1
    93.21(a)1
      4 (60.91 cM)5
    3329371  NM_198960.21  NP_945198.21 
     1267160065 
    chicken
    (Gallus gallus)
    Aves TFAP2E1 transcription factor AP-2 epsilon (activating enhancer more 74.47(n)
    77.05(a)
      419631  XM_417778.3  XP_417778.2 
    lizard
    (Anolis carolinensis)
    Reptilia TFAP2E6
    transcription factor AP-2 epsilon (activating enha...
    85(a)
    1 ↔ 1
    GL343843.1(128109-143083)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tfap2e1 transcription factor AP-2 epsilon (activating enhancer more 68.93(n)
    76.35(a)
      100170172  NM_001129928.1  NP_001123400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658822 hypothetical protein MGC65882 71.47(n)   393794  BC059800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-26
    AP-2
    44(a)
    1 → many
    3L(21579928-21606449)
    worm
    (Caenorhabditis elegans)
    Secernentea aptf-16
    Protein APTF-1 (aptf-1) mRNA, complete cds
    37(a)
    1 → many
    II(6454974-6456440) WBGene00019424


    ENSEMBL Gene Tree for TFAP2E (if available)
    TreeFam Gene Tree for TFAP2E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFAP2E gene
    TFAP2C2  TFAP2D2  TFAP2B2  TFAP2A2  
    4 SIMAP similar genes for TFAP2E using alignment to 1 protein entry:     AP2E_HUMAN:
    TFAP2B    TFAP2C    TFAP2A    TFAP2D

    TFAP2E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFAP2E (see all 491)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145442941,2
    F--36037181(+) CAAACA/GCAATC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs118015351,2
    C,H--36037192(+) CTGATC/GTCTGA 1 -- us2k1 tfbs32Minor allele frequency- G:0.04NA WA 120
    rs122391851,2
    C,F--36037205(+) CATCTC/TGAGCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs64259481,2
    C,F,A,H--36037222(+) TTGCAG/AAGCTT 1 -- us2k126Minor allele frequency- A:0.36NS EA NA WA CSA 2708
    rs1891562361,2
    --36037259(+) CTCGCC/TGGCGG 1 -- us2k10--------
    rs1477830091,2
    C--36037273(+) CAGAC-/TTCAGAA 1 -- us2k10--------
    rs1820392871,2
    --36037532(+) CCCCTA/GCTTTT 1 -- us2k10--------
    rs1179499191,2
    C,F--36037611(+) GTTAGG/CCAGAG 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs783223501,2
    C,F--36037659(+) GAGAAT/CAGTGA 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1157600261,2
    F--36037740(+) CATTTA/GACCTC 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for TFAP2E (36038971 - 36060929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TFAP2E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746741CNV Deletion23290073
    esv2746730CNV Deletion23290073
    esv2746719CNV Deletion23290073
    esv2746752CNV Deletion23290073
    nsv870679CNV Loss21882294
    nsv433CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TFAP2E
    DNA2.0 Custom Variant and Variant Library Synthesis for TFAP2E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614428    OMIM disorders: --

    1 disease for TFAP2E:    
    About MalaCards
    colorectal cancer


    TFAP2E for disorders           About GeneDecksing


    Export disorders for TFAP2E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFAP2E gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TFAP2E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family. (PubMed id 14636996)1, 2, 3 Tummala R.... Sinha S. (Gene 2003)
    2. The transcription factor activating enhancer-binding protein epsilon (AP-2I/) regulates the core promoter of type II collagen (COL2A1). (PubMed id 23331625)1 Niebler S. and Bosserhoff A.K. (FEBS J. 2013)
    3. TFAP2E-DKK4 and chemoresistance in colorectal cancer. (PubMed id 22216841)1 Ebert M.P....Schmid R.M. (N. Engl. J. Med. 2012)
    4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    5. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. (PubMed id 20862309)1 Van Otterloo E....Cornell R.A. (PLoS Genet. 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339488 HGNC: 30774 AceView: AP2E Ensembl:ENSG00000116819 euGenes: HUgn339488
    ECgene: TFAP2E H-InvDB: TFAP2E

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFAP2E Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Activating_protein_2

    (Patent information from GeneIP,
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    Patent Information for TFAP2E gene:
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