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Aliases for TFAP2E Gene

Aliases for TFAP2E Gene

  • Transcription Factor AP-2 Epsilon (Activating Enhancer Binding Protein 2 Epsilon) 2 3
  • Activating Enhancer-Binding Protein 2-Epsilon 3 4
  • AP2-Epsilon 3 4
  • Adaptor-Related Protein Complex 2, Epsilon Subunit 3
  • Transcription Factor AP-2-Epsilon 3
  • AP2E 3

External Ids for TFAP2E Gene

Summaries for TFAP2E Gene

GeneCards Summary for TFAP2E Gene

TFAP2E (Transcription Factor AP-2 Epsilon (Activating Enhancer Binding Protein 2 Epsilon)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TFAP2C.

UniProtKB/Swiss-Prot for TFAP2E Gene

  • Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFAP2E Gene

Genomics for TFAP2E Gene

Genomic Location for TFAP2E Gene

Start:
35,565,863 bp from pter
End:
35,595,328 bp from pter
Size:
29,466 bases
Orientation:
Plus strand

Genomic View for TFAP2E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFAP2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFAP2E Gene

Regulatory Elements for TFAP2E Gene

Proteins for TFAP2E Gene

  • Protein details for TFAP2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VUC0-AP2E_HUMAN
    Recommended name:
    Transcription factor AP-2-epsilon
    Protein Accession:
    Q6VUC0
    Secondary Accessions:
    • Q8IW12

    Protein attributes for TFAP2E Gene

    Size:
    442 amino acids
    Molecular mass:
    46212 Da
    Quaternary structure:
    • Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
    SequenceCaution:
    • Sequence=AAH41175.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAX07409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TFAP2E Gene

Proteomics data for TFAP2E Gene at MOPED

Post-translational modifications for TFAP2E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFAP2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFAP2E Gene

Domains for TFAP2E Gene

Protein Domains for TFAP2E Gene

UniProtKB/Swiss-Prot:

AP2E_HUMAN
Family:
  • Belongs to the AP-2 family.:
    • Q6VUC0
genes like me logo Genes that share domains with TFAP2E: view

No data available for Gene Families for TFAP2E Gene

Function for TFAP2E Gene

Molecular function for TFAP2E Gene

UniProtKB/Swiss-Prot Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for TFAP2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with TFAP2E: view

Phenotypes for TFAP2E Gene

genes like me logo Genes that share phenotypes with TFAP2E: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TFAP2E Gene

Localization for TFAP2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFAP2E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFAP2E Gene COMPARTMENTS Subcellular localization image for TFAP2E gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TFAP2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TFAP2E: view

Pathways for TFAP2E Gene

SuperPathways for TFAP2E Gene

No Data Available

Interacting Proteins for TFAP2E Gene

Gene Ontology (GO) - Biological Process for TFAP2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0042127 regulation of cell proliferation IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TFAP2E: view

No data available for Pathways by source for TFAP2E Gene

Transcripts for TFAP2E Gene

mRNA/cDNA for TFAP2E Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFAP2E Gene

Transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFAP2E Gene

No ASD Table

Relevant External Links for TFAP2E Gene

GeneLoc Exon Structure for
TFAP2E
ECgene alternative splicing isoforms for
TFAP2E

Expression for TFAP2E Gene

mRNA expression in normal human tissues for TFAP2E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFAP2E Gene

This gene is overexpressed in Brain - Cerebellum (9.8) and Brain - Cerebellar Hemisphere (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TFAP2E Gene

SOURCE GeneReport for Unigene cluster for TFAP2E Gene Hs.567844

mRNA Expression by UniProt/SwissProt for TFAP2E Gene

Q6VUC0-AP2E_HUMAN
Tissue specificity: Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
genes like me logo Genes that share expressions with TFAP2E: view

Orthologs for TFAP2E Gene

This gene was present in the common ancestor of animals.

Orthologs for TFAP2E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFAP2E 36
  • 99.68 (n)
  • 99.76 (a)
TFAP2E 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFAP2E 36
  • 91.57 (n)
  • 96.36 (a)
TFAP2E 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfap2e 36
  • 87.48 (n)
  • 93.21 (a)
Tfap2e 16
Tfap2e 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TFAP2E 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFAP2E 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tfap2e 36
  • 87.78 (n)
  • 93.89 (a)
chicken
(Gallus gallus)
Aves TFAP2E 36
  • 74.47 (n)
  • 77.05 (a)
TFAP2E 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFAP2E 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfap2e 36
  • 68.93 (n)
  • 76.35 (a)
zebrafish
(Danio rerio)
Actinopterygii tfap2e 36
  • 68.05 (n)
  • 68.54 (a)
tfap2e 37
  • 71 (a)
OneToOne
zgc65882 36
fruit fly
(Drosophila melanogaster)
Insecta AP-2 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aptf-1 37
  • 37 (a)
OneToMany
Species with no ortholog for TFAP2E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFAP2E Gene

ENSEMBL:
Gene Tree for TFAP2E (if available)
TreeFam:
Gene Tree for TFAP2E (if available)

Paralogs for TFAP2E Gene

Paralogs for TFAP2E Gene

Selected SIMAP similar genes for TFAP2E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFAP2E: view

Variants for TFAP2E Gene

Sequence variations from dbSNP and Humsavar for TFAP2E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs728598 -- 35,594,892(+) TTTGT(C/T)TCATG utr-variant-3-prime
rs2107783 -- 35,570,571(-) ACTTG(C/G)TAGTC intron-variant
rs2158595 -- 35,570,345(-) aggag(G/T)ttgag intron-variant
rs2301902 -- 35,574,361(-) CCGAG(A/C)GGTGC synonymous-codon, reference
rs3944110 -- 35,575,330(-) TCCCA(C/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TFAP2E Gene

Variant ID Type Subtype PubMed ID
nsv870679 CNV Loss 21882294
esv2746719 CNV Deletion 23290073
esv2746730 CNV Deletion 23290073
esv2746741 CNV Deletion 23290073
esv2746752 CNV Deletion 23290073
nsv433 CNV Loss 18451855

Relevant External Links for TFAP2E Gene

HapMap Linkage Disequilibrium report
TFAP2E

Disorders for TFAP2E Gene

No disorders were found for TFAP2E Gene.

No data available for UniProtKB/Swiss-Prot for TFAP2E Gene

Publications for TFAP2E Gene

  1. Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family. (PMID: 14636996) Tummala R. … Sinha S. (Gene 2003) 2 3 4
  2. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. (PMID: 20862309) Van Otterloo E. … Cornell R.A. (PLoS Genet. 2010) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. TFAP2E-DKK4 and chemoresistance in colorectal cancer. (PMID: 22216841) Ebert M.P. … Schmid R.M. (N. Engl. J. Med. 2012) 3
  5. The transcription factor activating enhancer-binding protein epsilon (AP-2I/) regulates the core promoter of type II collagen (COL2A1). (PMID: 23331625) Niebler S. … Bosserhoff A.K. (FEBS J. 2013) 3

Products for TFAP2E Gene

Sources for TFAP2E Gene

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