Aliases for TFAP2E Gene
External Ids for TFAP2E Gene
GeneCards Summary for TFAP2E Gene
TFAP2E (Transcription Factor AP-2 Epsilon (Activating Enhancer Binding Protein 2 Epsilon)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TFAP2C.
UniProtKB/Swiss-Prot for TFAP2E Gene
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).