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TFAP2D Gene

protein-coding   GIFtS: 47
GCID: GC06P050681

Transcription Factor AP-2 Delta (Activating Enhancer Binding...

(Previous name: transcription factor AP-2 beta (activating enhancer-binding...)
(Previous symbol: TFAP2BL1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor AP-2 Delta (Activating Enhancer Binding Protein 2
Delta)1 2
     AP2-delta2 3
TFAP2BL11 2 3 5     Activating Enhancer Binding Protein 2 Beta-Like 12
Transcription Factor AP-2 Beta (Activating Enhancer-Binding Protein 2
Beta)-Like 11 2
     AP-2 Like2
Activating Enhancer-Binding Protein 2-Delta2 3     Transcription Factor AP-2 Beta (Activating Enhancer Binding Protein 2
Beta)-Like 12
Transcription Factor AP-2-Beta-Like 12 3     Transcription Factor AP-2-Delta2

External Ids:    HGNC: 155811   Entrez Gene: 837412   Ensembl: ENSG000000081977   OMIM: 6101615   UniProtKB: Q7Z6R93   

Export aliases for TFAP2D gene to outside databases

Previous GC identifers: GC06P050789 GC06P050413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TFAP2D Gene:
TFAP2D (transcription factor AP-2 delta (activating enhancer binding protein 2 delta)) is a protein-coding gene. Diseases associated with TFAP2D include breast and colorectal cancer, and parkinson's disease. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is TFAP2C.

UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements
to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and
activate genes involved in a large spectrum of important biological functions including proper eye, face, body
wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha
and MYC (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TFAP2D gene promoter:
         E2F-3a   E2F-4   AP-2alpha isoform 3   E2F-2   AP-2alpha isoform 2   E2F   E2F-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTFAP2D promoter sequence
   Search Chromatin IP Primers for TFAP2D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TFAP2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

TFAP2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP2D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P050681:  view genomic region     (about GC identifiers)

Start:
50,681,257 bp from pter      End:
50,740,746 bp from pter
Size:
59,490 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9 (See protein sequence)
Recommended Name: Transcription factor AP-2-delta  
Size: 452 amino acids; 49578 Da
Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity)
Secondary accessions: Q8IWX0

Explore the universe of human proteins at neXtProt for TFAP2D: NX_Q7Z6R9

Explore proteomics data for TFAP2D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TFAP2D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_758438.2  
    ENSEMBL proteins: 
     ENSP00000008391  

    TFAP2D Human Recombinant Protein Products:

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    Novus Biologicals TFAP2D Protein
    Novus Biologicals TFAP2D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TFAP2D Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TFAP2D

    TFAP2D Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004979 TF_AP2
     IPR013854 TF_AP2_C

    Graphical View of Domain Structure for InterPro Entry Q7Z6R9

    ProtoNet protein and cluster: Q7Z6R9

    1 Blocks protein domain: IPB004979 Transcription factor AP-2 signature

    UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9
    Similarity: Belongs to the AP-2 family


    TFAP2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP2D_HUMAN, Q7Z6R9
    Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements
    to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and
    activate genes involved in a large spectrum of important biological functions including proper eye, face, body
    wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha
    and MYC (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding ----
         
    TFAP2D for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tfap2d):
     cellular  nervous system 

    TFAP2D for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFAP2D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFAP2D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFAP2D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFAP2D

    miRNA
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    Block miRNA regulation of human, mouse, rat TFAP2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP2D (see all 18):
    hsa-miR-4291 hsa-miR-875-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-3074-3p hsa-miR-181a-2* hsa-miR-424 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidTFAP2D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TFAP2D
    Predesigned siRNA for gene silencing in human, mouse, rat TFAP2D

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TFAP2D (NM_172238)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2D

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP2D_HUMAN, Q7Z6R9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    TFAP2D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TFAP2D
    Interactions:

        Search GeneGlobe Interaction Network for TFAP2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TFAP2D (Q7Z6R93 ENSP000000083914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASH2LQ9UBL33, ENSP000003408964I2D: score=1 STRING: ENSP00000340896
    TFAP2AP055493, ENSP000003689244I2D: score=3 STRING: ENSP00000368924
    TFAP2BENSP000003772654STRING: ENSP00000377265
    TFAP2CENSP000002010314STRING: ENSP00000201031
    TFAP2EENSP000003623324STRING: ENSP00000362332
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0043066negative regulation of apoptotic process ----
    GO:0043524negative regulation of neuron apoptotic process IEA--
    GO:0045893positive regulation of transcription, DNA-templated ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    TFAP2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TFAP2D (AP2D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TFAP2D gene: 
    NM_172238.3  

    Unigene Cluster for TFAP2D:

    Transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
    Hs.434107  [show with all ESTs]
    Unigene Representative Sequence: AY028376
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000008391(uc003paf.3 uc011dwt.2) ENST00000492804
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TFAP2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TFAP2D (see all 18):
    hsa-miR-4291 hsa-miR-875-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-3074-3p hsa-miR-181a-2* hsa-miR-424 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidTFAP2D 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TFAP2D
    Predesigned siRNA for gene silencing in human, mouse, rat TFAP2D
    Clone
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    OriGene clones in human, mouse for TFAP2D (see all 6)
    OriGene ORF clones in mouse, rat for TFAP2D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TFAP2D (NM_172238)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFAP2D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2D
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TFAP2D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TFAP2D
      QuantiTect SYBR Green Assays in human, mouse, rat TFAP2D
      QuantiFast Probe-based Assays in human, mouse, rat TFAP2D

    Additional mRNA sequence: 

    AY028376.1 BC144200.1 

    1 DOTS entry:

    DT.97823845 

    6 AceView cDNA sequences:

    BM680326 BM724157 NM_172238 AY028376 BM663523 BM685956 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TFAP2D expression in normal human tissues (normalized intensities)      TFAP2D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACTCGGA
    TFAP2D Expression
    About this image


    TFAP2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate
    TFAP2D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TFAP2D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434107

    UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9
    Tissue specificity: Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate,
    and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney,
    liver, lung or pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TFAP2D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tfap2d1 , 5 transcription factor AP-2, delta1, 5 93.29(n)1
    99.56(a)1
      1 (6.08 cM)5
    2268961  NM_153154.21  NP_694794.11 
     191030225 
    chicken
    (Gallus gallus)
    Aves TFAP2D1 transcription factor AP-2 delta (activating enhancer more 87.09(n)
    98.45(a)
      771525  NM_001135785.1  NP_001129257.1 
    lizard
    (Anolis carolinensis)
    Reptilia TFAP2D6
    transcription factor AP-2 delta (activating enhanc...
    96(a)
    1 ↔ 1
    1(122137216-122211511)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tfap2d1 transcription factor AP-2 delta (activating enhancer more 78.61(n)
    92.92(a)
      100492778  XM_002933582.2  XP_002933628.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tfap2d1 transcription factor AP-2 delta (activating enhancer more 77.04(n)
    90.67(a)
      566838  NM_001025546.1  NP_001020717.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-26
    AP-2
    40(a)
    1 → many
    3L(21579928-21606449)
    worm
    (Caenorhabditis elegans)
    Secernentea aptf-16
    Protein APTF-1 (aptf-1) mRNA, complete cds
    32(a)
    1 → many
    II(6454974-6456440) WBGene00019424


    ENSEMBL Gene Tree for TFAP2D (if available)
    TreeFam Gene Tree for TFAP2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TFAP2D gene
    TFAP2C2  TFAP2E2  TFAP2B2  TFAP2A2  
    4 SIMAP similar genes for TFAP2D using alignment to 1 protein entry:     AP2D_HUMAN:
    TFAP2C    TFAP2B    TFAP2A    TFAP2E

    TFAP2D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TFAP2D (see all 1168)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0369754
    A breast cancer sample4--see VAR_0369752 V F mis40--------
    rs1453838391,2
    C--50442132(+) TAGAT-/GATA  
            
    GATAG
    1 -- int10--------
    rs1484595901,2
    --50679350(+) GTTCAC/GAGGGT 1 -- us2k10--------
    rs747321451,2
    --50679463(+) TGAGGA/GGGGCT 1 -- us2k10--------
    rs1161482191,2
    C,F--50679508(+) GTGGAA/GCAAAC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1849158501,2
    --50679649(+) AAGGTA/GTATCT 1 -- us2k10--------
    rs1897570941,2
    --50679721(+) TGACCA/GGGACT 1 -- us2k10--------
    rs1916057771,2
    --50679764(+) GCGCAA/CCTGGG 1 -- us2k10--------
    rs1837441951,2
    --50679780(+) CCCAAC/GATAAC 1 -- us2k10--------
    rs779380421,2
    C,F--50679830(+) TTTCCC/AAGGGG 1 -- us2k11Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for TFAP2D (50681257 - 50740746 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TFAP2D: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TFAP2D
    DNA2.0 Custom Variant and Variant Library Synthesis for TFAP2D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610161    OMIM disorders: --

    5 diseases for TFAP2D:    About MalaCards
    breast and colorectal cancer    parkinson's disease    retinitis    colorectal cancer
    prostatitis


    TFAP2D for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for TFAP2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TFAP2D gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TFAP2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1). (PubMed id 11733187)1, 2, 3, 9 Cheng C.... Mao Y. (Int. J. Biochem. Cell Biol. 2002)
    2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    3. Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M.... Kim N.S. (DNA Res. 2006)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    5. Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PubMed id 16684505)1 Wenke A.K....Bosserhoff A.K. (Biochem. Biophys. Res. Commun. 2006)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83741 HGNC: 15581 AceView: TFAP2BL1 Ensembl:ENSG00000008197 euGenes: HUgn83741
    ECgene: TFAP2D H-InvDB: TFAP2D

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TFAP2D Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Activating_protein_2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TFAP2D gene:
    Search GeneIP for patents involving TFAP2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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