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Aliases for TFAP2D Gene

Aliases for TFAP2D Gene

  • Transcription Factor AP-2 Delta (Activating Enhancer Binding Protein 2 Delta) 2 3
  • TFAP2BL1 3 4 6
  • Transcription Factor AP-2 Beta (Activating Enhancer-Binding Protein 2 Beta)-Like 1 2 3
  • Activating Enhancer-Binding Protein 2-Delta 3 4
  • Transcription Factor AP-2-Beta-Like 1 3 4
  • AP2-Delta 3 4
  • Transcription Factor AP-2 Beta (Activating Enhancer Binding Protein 2 Beta)-Like 1 3
  • Activating Enhancer Binding Protein 2 Beta-Like 1 3
  • Transcription Factor AP-2-Delta 3
  • AP-2 Like 3

External Ids for TFAP2D Gene

Previous HGNC Symbols for TFAP2D Gene

  • TFAP2BL1

Previous GeneCards Identifiers for TFAP2D Gene

  • GC06P050789
  • GC06P050413

Summaries for TFAP2D Gene

GeneCards Summary for TFAP2D Gene

TFAP2D (Transcription Factor AP-2 Delta (Activating Enhancer Binding Protein 2 Delta)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is TFAP2E.

UniProtKB/Swiss-Prot for TFAP2D Gene

  • Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TFAP2D Gene

Genomics for TFAP2D Gene

Genomic Location for TFAP2D Gene

Start:
50,713,544 bp from pter
End:
50,773,033 bp from pter
Size:
59,490 bases
Orientation:
Plus strand

Genomic View for TFAP2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TFAP2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TFAP2D Gene

Proteins for TFAP2D Gene

  • Protein details for TFAP2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6R9-AP2D_HUMAN
    Recommended name:
    Transcription factor AP-2-delta
    Protein Accession:
    Q7Z6R9
    Secondary Accessions:
    • Q8IWX0

    Protein attributes for TFAP2D Gene

    Size:
    452 amino acids
    Molecular mass:
    49578 Da
    Quaternary structure:
    • Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).

neXtProt entry for TFAP2D Gene

Proteomics data for TFAP2D Gene at MOPED

Post-translational modifications for TFAP2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TFAP2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TFAP2D Gene

Domains for TFAP2D Gene

Protein Domains for TFAP2D Gene

Suggested Antigen Peptide Sequences for TFAP2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6R9

UniProtKB/Swiss-Prot:

AP2D_HUMAN :
  • Q7Z6R9
Family:
  • Belongs to the AP-2 family.
genes like me logo Genes that share domains with TFAP2D: view

No data available for Gene Families for TFAP2D Gene

Function for TFAP2D Gene

Molecular function for TFAP2D Gene

UniProtKB/Swiss-Prot Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).

Gene Ontology (GO) - Molecular Function for TFAP2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TFAP2D: view

Phenotypes for TFAP2D Gene

genes like me logo Genes that share phenotypes with TFAP2D: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TFAP2D Gene

Localization for TFAP2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TFAP2D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TFAP2D Gene COMPARTMENTS Subcellular localization image for TFAP2D gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TFAP2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TFAP2D: view

Pathways for TFAP2D Gene

SuperPathways for TFAP2D Gene

No Data Available

Gene Ontology (GO) - Biological Process for TFAP2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0042127 regulation of cell proliferation IBA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TFAP2D: view

No data available for Pathways by source for TFAP2D Gene

Transcripts for TFAP2D Gene

mRNA/cDNA for TFAP2D Gene

(6) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TFAP2D Gene

Transcription factor AP-2 delta (activating enhancer binding protein 2 delta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TFAP2D Gene

No ASD Table

Relevant External Links for TFAP2D Gene

GeneLoc Exon Structure for
TFAP2D
ECgene alternative splicing isoforms for
TFAP2D

Expression for TFAP2D Gene

mRNA expression in normal human tissues for TFAP2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TFAP2D Gene

This gene is overexpressed in Brain - Amygdala (40.8) and Brain - Frontal Cortex (BA9) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TFAP2D Gene

SOURCE GeneReport for Unigene cluster for TFAP2D Gene Hs.434107

mRNA Expression by UniProt/SwissProt for TFAP2D Gene

Q7Z6R9-AP2D_HUMAN
Tissue specificity: Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas.
genes like me logo Genes that share expressions with TFAP2D: view

Orthologs for TFAP2D Gene

This gene was present in the common ancestor of animals.

Orthologs for TFAP2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TFAP2D 35
  • 99.78 (n)
  • 100 (a)
TFAP2D 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TFAP2D 35
  • 94.99 (n)
  • 99.56 (a)
TFAP2D 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TFAP2D 35
  • 96.98 (n)
  • 100 (a)
TFAP2D 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tfap2d 35
  • 93.29 (n)
  • 99.56 (a)
Tfap2d 16
Tfap2d 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TFAP2D 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TFAP2D 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves TFAP2D 35
  • 87.09 (n)
  • 98.45 (a)
TFAP2D 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TFAP2D 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tfap2d 35
  • 78.61 (n)
  • 92.92 (a)
zebrafish
(Danio rerio)
Actinopterygii tfap2d 35
  • 77.04 (n)
  • 90.67 (a)
tfap2d 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AP-2 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aptf-1 36
  • 32 (a)
OneToMany
Species with no ortholog for TFAP2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TFAP2D Gene

ENSEMBL:
Gene Tree for TFAP2D (if available)
TreeFam:
Gene Tree for TFAP2D (if available)

Paralogs for TFAP2D Gene

Paralogs for TFAP2D Gene

Selected SIMAP similar genes for TFAP2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TFAP2D: view

Variants for TFAP2D Gene

Sequence variations from dbSNP and Humsavar for TFAP2D Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs760899 -- 50,725,894(-) CTGCA(A/G)CCTTG intron-variant
rs994064 -- 50,716,909(+) AGCCC(C/T)TACAG intron-variant
rs1015388 -- 50,741,827(-) CTGCC(A/G)TCACC intron-variant
rs1178213 -- 50,715,749(-) GTGTG(A/T)GAGAG intron-variant
rs1569577 -- 50,741,994(-) GAGTT(C/T)GACTG intron-variant

Relevant External Links for TFAP2D Gene

HapMap Linkage Disequilibrium report
TFAP2D
Human Gene Mutation Database (HGMD)
TFAP2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TFAP2D Gene

Disorders for TFAP2D Gene

No disorders were found for TFAP2D Gene.

No data available for UniProtKB/Swiss-Prot for TFAP2D Gene

Publications for TFAP2D Gene

  1. Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1). (PMID: 11733187) Cheng C. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PMID: 16684505) Wenke A.K. … Bosserhoff A.K. (Biochem. Biophys. Res. Commun. 2006) 3
  4. Identification of genes related to Parkinson's disease using expressed sequence tags. (PMID: 17213182) Kim J.M. … Kim N.S. (DNA Res. 2006) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for TFAP2D Gene

Sources for TFAP2D Gene

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