TFAP2D Gene
protein-coding GIFtS: 44
GCID: GC06P050681
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transcription factor AP-2 delta (activating enhancer binding...(Previous name: transcription factor AP-2 beta (activating enhancer-binding...)
(Previous symbol: TFAP2BL1)
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Aliases
for TFAP2D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Factor AP-2 Delta (Activating Enhancer Binding Protein 2Delta)1 2 | | AP2-Delta1 | | TFAP2BL11 2 3 5 | | Activating Enhancer Binding Protein 2 Beta-Like 12 | | Transcription Factor AP-2 Beta (Activating Enhancer-Binding Protein 2Beta)-Like 11 2 | | AP-2 Like2 | | Activating Enhancer-Binding Protein 2-Delta2 3 | | Transcription Factor AP-2 Beta (Activating Enhancer Binding Protein 2Beta)-Like 12 | | Transcription Factor AP-2-Beta-Like 12 3 | | Transcription Factor AP-2-Delta2 |
Export aliases for TFAP2D gene to outside databasesPrevious GC identifers: GC06P050789 GC06P050413 |
Summaries
for TFAP2D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements toregulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activategenes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb andneural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (Bysimilarity)
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Genomic Views
for TFAP2D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TFAP2D gene promoter:
E2F-3a E2F-4 AP-2alpha isoform 3 E2F-2 AP-2alpha isoform 2 E2F E2F-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TFAP2D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFAP2D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12.3TFAP2D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P050681: view genomic region
(about GC identifiers)
Start:
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50,681,257 bp from pter |
End:
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50,740,746 bp from pter |
Size:
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59,490 bases |
Orientation:
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plus strand |
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Proteins
for TFAP2D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9 (See
protein sequence)Recommended Name: Transcription factor AP-2-delta Size: 452 amino acids; 49578 Da
Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8IWX0Explore the universe of human proteins at neXtProt for TFAP2D: NX_Q7Z6R9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z6R9
TFAP2D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_758438.2
ENSEMBL proteins: ENSP00000008391
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005667 | transcription factor complex |
IEA | -- |
TFAP2D for ontologies About GeneDecksing
TFAP2D Antibody Products:
Assay Products for TFAP2D: |
Protein
Domains /
Families
for TFAP2D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TFAP2D for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z6R9ProtoNet protein and cluster: Q7Z6R9 1 Blocks protein family: IPB004979 Transcription factor AP-2 signature
UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9Similarity: Belongs to the AP-2 family |
Function
for TFAP2D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements toregulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activategenes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb andneural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TFAP2D (NM_172238) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TFAP2D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2D |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
TFAP2D for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tfap2d):
TFAP2D for phenotypes About GeneDecksing
|
Pathways & Interactions
for TFAP2D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TFAP2D
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for TFAP2D (Q7Z6R93 ENSP000000083914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
IEA | -- |
TFAP2D for ontologies About GeneDecksing
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Drugs & Compounds
for TFAP2D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TFAP2D
Search CenterWatch for drugs/clinical trials and news about TFAP2D / AP2D
|
Transcripts
for TFAP2D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TFAP2D gene: NM_172238.3 Unigene Cluster for TFAP2D: Transcription factor AP-2 delta (activating enhancer binding protein 2 delta) Hs.434107 [show with all ESTs]Unigene Representative Sequence: AY0283762 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000008391(uc003paf.3 uc011dwt.2) ENST00000492804
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TFAP2D (NM_172238) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TFAP2D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2D |
Additional cDNA sequence: AY028376.1 BC144200.1 1 DOTS entry: DT.97823845 6 AceView cDNA sequences: BM680326 AY028376 BM724157 NM_172238 BM663523 BM685956
GeneLoc Exon Structure
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Expression
for TFAP2D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TFAP2D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAACTCGGA
About this image
See TFAP2D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TFAP2D
SOURCE GeneReport for Unigene cluster: Hs.434107
UniProtKB/Swiss-Prot: AP2D_HUMAN, Q7Z6R9Tissue specificity: Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, andexpressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver,lung or pancreas
SABiosciences Custom PCR Arrays for TFAP2D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFAP2D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TFAP2D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFAP2D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFAP2D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2D |
Orthologs
for TFAP2D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TFAP2D gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TFAP2D6 |
Uncharacterized protein |
90(a) |
1 ↔ 1 |
3(111073658-111125063) |
lizard
(Anolis carolinensis) |
Reptilia |
TFAP2D6 |
-- |
96(a) |
1 ↔ 1 |
1(122137302-122206524) |
zebrafish
(Danio rerio) |
Actinopterygii |
tfap2d1 |
transcription factor AP-2 delta (activating enhancer more |
77.04(n)
90.67(a) |
|
566838 NM_001025546.1 NP_001020717.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
aptf-16 |
AP-2 Transcription Factor family member (aptf-1) |
32(a) |
1 ↔ 1 |
II(6454942-6456408) |
ENSEMBL Gene Tree for TFAP2D (if available)
TreeFam Gene Tree for TFAP2D (if available) |
Paralogs
for TFAP2D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TFAP2D gene
- TFAP2C2 TFAP2E2 TFAP2B2 TFAP2A2
4 SIMAP similar genes for TFAP2D using alignment to 1 protein entry: AP2D_HUMAN:TFAP2C TFAP2B TFAP2A TFAP2E
TFAP2D for paralogs About GeneDecksing
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Genomic Variants
for TFAP2D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TFAP2D (50681257 - 50740746 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TFAP2D: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TFAP2D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TFAP2D for disorders About GeneDecksing
OMIM gene information: 610161
OMIM disorders: --
2  diseases for TFAP2D: About MalaCardsparkinson's disease prostatitis
Export disorders for TFAP2D gene to outside databases
|
Publications
for TFAP2D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TFAP2D gene integrated from 9 sources:
(articles sorted by number of sources associating them with TFAP2D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1). (PubMed id 11733187)1, 2, 3, 9 Cheng C.... Mao Y. (2002)
- Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M....Kim N.S. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PubMed id 16684505)1 Wenke A.K....Bosserhoff A.K. (2006)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TFAP2D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TFAP2D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TFAP2D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TFAP2D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TFAP2D | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Activating_protein_2 |
|
| | |
About This Section
| Patent Information for TFAP2D gene:
Search GeneIP for patents involving TFAP2D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TFAP2D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TFAP2D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFAP2D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TFAP2D | | | OriGene Protein Over-expression Lysate for TFAP2D | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TFAP2D | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TFAP2D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TFAP2D | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TFAP2D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFAP2D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFAP2D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TFAP2D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TFAP2D |
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| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2D |
|  |  |  | | | | Search ThermoFisher Antibodies for TFAP2D |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFAP2D |
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