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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TFAP2C Gene

protein-coding   GIFtS: 56
GCID: GC20P055204

transcription factor AP-2 gamma (activating enhancer binding...

(Previous name: transcription factor AP-2 gamma (activating enhancer-binding...)
 Explore 20 diseases affiliated with
TFAP2C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TFAP2C    

Aliases
for TFAP2C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transcription Factor AP-2 Gamma (Activating Enhancer Binding Protein 2
Gamma)1 2
     Activating Enhancer-Binding Protein 2 Gamma2 3
AP2-GAMMA1 2     Transcription Factor ERF-12 3
ERF11 2     Estrogen Receptor Factor 12
TFAP2G1 2     Transcription Factor AP-2 Gamma2
HAP-2g1     AP2-Gamma1
Transcription Factor AP-2 Gamma (Activating Enhancer-Binding Protein 2 Gamma)1 2     

External Ids:    HGNC: 117441   Entrez Gene: 70222   Ensembl: ENSG000000875107   OMIM: 6016025   UniProtKB: Q927543   

Export aliases for TFAP2C gene to outside databases

Previous GC identifers: GC20P054932 GC20P055842 GC20P055889 GC20P054637 GC20P051987


Summaries
for TFAP2C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TFAP2C:
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of
several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family
members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes,
face, body wall, limbs, and neural tube. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to
regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate
genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and
neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC

Gene Wiki entry for TFAP2C


Genomic Views
for TFAP2C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFAP2C gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TFAP2C promoter sequence
   Search SABiosciences Chromatin IP Primers for TFAP2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TFAP2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.2

TFAP2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP2C gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055204:  view genomic region     (about GC identifiers)

Start:
 55,204,358 bp from pter      End:
 55,214,339 bp from pter
Size:
 9,982 bases      Orientation:
 plus strand

Proteins
for TFAP2C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754 (See protein sequence)
Recommended Name: Transcription factor AP-2 gamma  
Size: 450 amino acids; 49177 Da
Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses
transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional
activity
Subcellular location: Nucleus (Probable)
Secondary accessions: O00685 O00730 Q86V30 Q8IVB6 Q9P1X2

Explore the universe of human proteins at neXtProt for TFAP2C: NX_Q92754

Post-translational modifications:

  • Sumoylated on Lys-10; which inhibits transcriptional activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92754

    • TFAP2C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003213.1  
    ENSEMBL proteins: 
     ENSP00000201031   ENSP00000390857   ENSP00000442274  

    Human Recombinant Protein Products: 
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    Novus Biologicals TFAP2C Proteins
    Novus Biologicals TFAP2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TFAP2C for ontologies           About GeneDecksing



    TFAP2C Antibody Products: 
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    ThermoFisher Antibodies for TFAP2C

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TFAP2C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TFAP2C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004979 TF_AP2
     IPR013854 TF_AP2_C
     IPR008123 TF_AP2_gamma

    Graphical View of Domain Structure for InterPro Entry Q92754

    ProtoNet protein and cluster: Q92754

    2 Blocks protein families:
    IPB004979 Transcription factor AP-2 signature
    IPB008123 Transcription factor AP-2 gamma signature


    UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754
    Domain: The WW-binding motif mediates interaction with WWOX
    Similarity: Belongs to the AP-2 family


    Function
    for TFAP2C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754
    Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to
    regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate
    genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and
    neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC
    Induction: During retinoic acid-mediated differentiation

         Genatlas biochemistry entry for TFAP2C:
    transcription factor 2 gamma (AP2 gamma) regulating the expression of genes required for development of ectodermal
    tissues

    miRNA
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    hsa-miR-498 hsa-miR-320a hsa-miR-137 hsa-miR-10b hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: TFAP2C 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell lines associated with TFAP2C: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
    PureStem SM30, NCr-fac & Meso-latp Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2C

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA11278550
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA11278550


    TFAP2C for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TFAP2C: Tfap2ctm1.1Hsc Tfap2ctm1Will
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tfap2c):
     embryogenesis  growth/size  mortality/aging  normal 

    TFAP2C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TFAP2C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    2Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    3Selected targets of ESR1
    		Selected targets of ESR11.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TFAP2C
        Selected targets of ESR1


    2 Cell Signaling Technology (CST) Pathways for TFAP2C
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control



    TFAP2C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFAP2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for TFAP2C (Q927541, 3 ENSP000002010314) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632791, 3, ENSP000003248974EBI-937309,EBI-80168 I2D: score=2 STRING: ENSP00000324897
    CITED2Q999671, 3, ENSP000003566234EBI-937309,EBI-937732 I2D: score=3 STRING: ENSP00000356623
    TP53P046373, ENSP000002693054I2D: score=3 STRING: ENSP00000269305
    CITED4Q96RK13, ENSP000003617214I2D: score=2 STRING: ENSP00000361721
    CITED1Q999663, ENSP000003885484I2D: score=1 STRING: ENSP00000388548
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001942hair follicle development IEA--
    GO:0003334keratinocyte development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9113991


    TFAP2C for ontologies           About GeneDecksing



    Drugs & Compounds
    for TFAP2C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TFAP2C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TFAP2C
    3 Novoseek chemical compound relationships for TFAP2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3beta-hydroxysteroid 44 1 11773066 (1)
    estrogen 29.2 4 7891714 (1), 15467710 (1), 9113991 (1), 17330235 (1)
    retinoic acid 6.35 3 15623634 (2), 15940248 (1)

    Search CenterWatch for drugs/clinical trials and news about TFAP2C / AP2C 

    Transcripts
    for TFAP2C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TFAP2C gene: 
    NM_003222.3  

    Unigene Cluster for TFAP2C:

    Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
    Hs.473152  [show with all ESTs]
    Unigene Representative Sequence: NM_003222
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000201031(uc002xya.3 uc010zzi.2) ENST00000416606 ENST00000544508


    miRNA
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    hsa-miR-498 hsa-miR-320a hsa-miR-137 hsa-miR-10b hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: TFAP2C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TFAP2C (see all 4)
    OriGene shRNA RFP: TFAP2C
    OriGene siRNA: TFAP2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TFAP2C
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK301572.1 AK314272.1 BC035664.1 BC051829.1 U85658.1 X95693.1 

    3 DOTS entries:

    DT.112064  DT.120798214  DT.95365798 

    24/59 AceView cDNA sequences (see all 59):

    AA632055 AI703244 AW593477 AA300897 NM_003222 BX108462 AI077463 BC051829 
    AI002216 AA399334 AA394236 AA035210 BC035664 BE327517 CA440747 BX360337 
    AI972428 BU154994 BF108600 BI772382 BU929407 AA581637 AI990857 AI638098 

    GeneLoc Exon Structure


    Expression
    for TFAP2C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TFAP2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TFAP2C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TrophoblastTrophoblastTrophoblast CellsExtraembryonic Tissues
    EyeInner Nuclear LayerEarly Immature Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerLate Immature Amacrine CellsAmacrine, Retina
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Gut TubeForegutForegut Endoderm CellsEndoderm
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/15 LifeMap Cells (see all 15) 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See TFAP2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TFAP2C

    SOURCE GeneReport for Unigene cluster: Hs.473152
        SABiosciences Custom PCR Arrays for TFAP2C
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFAP2C

    Orthologs
    for TFAP2C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TFAP2C gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tfap2c1 , 5 transcription factor AP-2, gamma1, 5 83.07(n)1
    89.76(a)1    		   2 (94.87 cM)5
    214201  NM_009335.21  NP_033361.21 
     1725495935 
    chicken
    (Gallus gallus)    		 Aves TFAP2C1 transcription factor AP-2 gamma (activating enhancer more 75.3(n)
    79.05(a)    		   419327  XM_417497.3  XP_417497.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TFAP2C6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343217.1(1788080-1810499)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684932 hypothetical protein MGC68493 72.26(n)    BC059962.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tfap2c1 transcription factor AP-2 gamma (activating enhancer more 65.6(n)
    69.02(a)    		   494033  NM_001008576.1  NP_001008576.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta AP-23 leg joint morphogenesis (sensu Holometabola)
    RNA more    		 49(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea K06A1.13 transcription factor AP-2 51(a)   II(6454923-6456389)   --


    ENSEMBL Gene Tree for TFAP2C (if available)
    TreeFam Gene Tree for TFAP2C (if available) 

    Paralogs
    for TFAP2C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TFAP2C gene
    TFAP2D2  TFAP2E2  TFAP2B2  TFAP2A2  
    4 SIMAP similar genes for TFAP2C using alignment to 3 protein entries:     AP2C_HUMAN (see all proteins):
    TFAP2A    TFAP2D    TFAP2E    TFAP2B

    TFAP2C for paralogs           About GeneDecksing



    Genomic Variants
    for TFAP2C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/207 NCBI SNPs in TFAP2C are shown (see all 207)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1479628521,2
    		--55202714(+) AATACC/TAGGAG 1 -- us2k10--------
    rs1489984011,2
    		--55202813(+) CTCCTG/TAGTGC 1 -- us2k10--------
    rs794930731,2
    		--55202891(+) CCGGTC/TGGAAA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1428225441,2
    		--55202928(+) AGGCCA/GGGGGA 1 -- us2k10--------
    rs38271021,2
    		C,F,H,--55202984(+) CCACCC/G/TGGGTC 1 -- us2k119NS EA NA WA CSA 2344
    rs786838581,2
    		C,F,--55203006(+) TAAAGT/CTCAAA 1 -- us2k11Minor allele frequency- C:0.07NA 120
    rs1914507431,2
    		--55203055(+) ATTCCA/GTGGAT 1 -- us2k10--------
    rs1828230051,2
    		--55203126(+) ATCGTA/TTTCAG 1 -- us2k10--------
    rs1887361981,2
    		--55203196(+) GAGCCA/CGTTGG 1 -- us2k10--------
    rs72711331,2
    		C,F,A,--55203471(+) ACTTCC/ATGCAC 1 -- us2k11Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for TFAP2C (55204358 - 55214339 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TFAP2C: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TFAP2C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TFAP2C for disorders           About GeneDecksing

    OMIM gene information: 601602    OMIM disorders: --

    20 diseases for TFAP2C:    About MalaCards
    uterine fibroid    tetralogy of fallot    exencephaly    adenoid cystic carcinoma
    germ cell tumor    dysgerminoma    adenoiditis    endometrial carcinoma
    seminoma    breast carcinoma    breast cancer    carcinoma
    cervical cancer    cervicitis    gastric cancer    adenoma
    cerebritis    melanoma    adenocarcinoma    neuronitis

    6 Novoseek disease relationships for TFAP2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 57.7 12 16867219 (3), 16636674 (2), 9113991 (2), 15623634 (1) (see all 7)
    breast cancer 44.7 19 19671168 (4), 9850080 (3), 18825690 (3), 15467710 (3) (see all 7)
    carcinoma 34.6 10 11429425 (3), 15623634 (1), 16420676 (1), 12490322 (1) (see all 8)
    endometrial carcinoma 25.6 1 9113991 (1)
    tumors 16.6 22 15623634 (5), 15830141 (3), 16416736 (2), 19671168 (2) (see all 8)
    cancer 0 1 17330235 (1)

    Tumor Gene Database (TGDB): TFAP2C

    Export disorders for TFAP2C gene to outside databases

    Publications
    for TFAP2C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TFAP2C gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with TFAP2C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. (PubMed id 8661133)1, 2, 3, 9 Williamson J.A....Hurst H.C. (1996)
    2. Identification of ERF-1 as a member of the AP2 transcription factor family. (PubMed id 9113991)1, 2, 9 McPherson L.A.... Weigel R.J. (1997)
    3. Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. (PubMed id 15548692)1, 2, 9 Aqeilan R.I....Croce C.M. (2004)
    4. The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. (PubMed id 19115315)1, 2 Ding X....Zhang J. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. (PubMed id 12586840)1, 2 Braganca J....Bhattacharya S. (2003)
    7. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. (PubMed id 12072434)1, 2 Eloranta J.J. and Hurst H.C. (2002)
    8. Human CREB-binding protein/p300-interacting transactivator with ED- rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PubMed id 11744733)1, 2 Braganca J.... Bhattacharya S. (2002)
    9. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. (PubMed id 11694877)1, 2 Bamforth S.D....Bhattacharya S. (2001)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    External Searches for TFAP2C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing TFAP2C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7022 HGNC: 11744 AceView: TFAP2C Ensembl:ENSG00000087510 euGenes: HUgn7022
    ECgene: TFAP2C H-InvDB: TFAP2C

    Other Databases showing TFAP2C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TFAP2C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TFAP2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TFAP2C Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Activating_protein_2

    Intellectual Property
    for TFAP2C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TFAP2C gene:
    Search GeneIP for patents involving TFAP2C

    GeneCards and IP:
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