TFAP2C Gene
protein-coding GIFtS: 60
GC20P054637
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transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (Previous name: transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma) ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for TFAP2C
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AP2-GAMMA 1, 2 | | AP2-gamma 3 | | ERF1 1, 2 | | OTTHUMP00000031355 2 | | TFAP2G 1, 2 | | hAP-2g 1, 2 |
| | | Descriptions |
|---|
| Activating enhancer-binding protein 2 gamma 3 | | Transcription factor ERF-1 3 | | estrogen receptor factor 1 2 | | transcription factor AP-2 gamma 2 | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 2 | transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma) 1, 2 |
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| | Search outside databases for aliases for TFAP2C genePrevious GC identifers: GC20P054932 GC20P055842 GC20P055889 |
Summaries for TFAP2C(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TFAP2C: The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq] UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC |
Genomic Location for TFAP2C
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TFAP2C gene 
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.31 HGNC cytogenetic band: 20q13.2TFAP2C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P054637:
(about GC identifiers)
Start:
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54,637,765 bp from pter |
End:
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54,647,746 bp from pter |
Size:
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9,982 bases |
Orientation:
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plus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011362.9
| Proteins for TFAP2C
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754 (See
protein sequence)Recommended Name: Transcription factor AP-2 gamma Size: 450 amino acids; 49177 Da
Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I
Subcellular location: Nucleus (Probable)
Secondary accessions: O00685 O00730 Q86V30 Q8IVB6 Q9P1X2Post-translational modifications:
Sumoylated on Lys-10; which inhibits transcriptional activity1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003213.1
ENSEMBL proteins: ENSP00000201031
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for TFAP2C:  | Invitrogen Antibodies for TFAP2C |  | Millipore Mono- and Polyclonal Antibodies for the study of TFAP2C |  | Sigma-Aldrich Antibodies for TFAP2C |  | R&D Systems Antibodies for TFAP2C (AP-2 gamma) |  | Cell Signaling Technology (CST) Antibodies for TFAP2C  (AP-2gamma) |  | Antibodies from Abcam (AP2 gamma), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (TFAP2C) |  | Novus Biologicals Antibodies for TFAP2C |
Assays for TFAP2C: | Protein
Domains/ Families for TFAP2C(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q92754
ProtoNet protein and cluster: Q92754 2 Blocks protein families: IPB004979 Transcription factor AP-2 signature IPB008123 Transcription factor AP-2 gamma signature
UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754Domain: The WW-binding motif mediates interaction with WWOXSimilarity: Belongs to the AP-2 family | Gene Function for TFAP2C
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003222
Applied Biosystems Silencer® siRNAs for TFAP2C
Sigma-Aldrich siRNA for TFAP2C  Sigma-Aldrich shRNA for TFAP2C  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003222                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003222                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003222 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003222
UniProtKB/Swiss-Prot: AP2C_HUMAN, Q92754Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYCInduction: During retinoic acid-mediated differentiationGenatlas biochemistry entry for TFAP2C:transcription factor 2 gamma (AP2 gamma) regulating the expression of genes required for development of ectodermal tissues4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Tcfap2c):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TFAP2C
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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Gene Network CentralTM Interacting Genes and Proteins Network for TFAP2C 
5/11 Interacting proteins for TFAP2C (ENSP000002010313 Q927541) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
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Drugs & Compounds for TFAP2C(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for TFAP2C 1 Novoseek chemical compound relationship for TFAP2C gene
About this table
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Transcripts for TFAP2C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003222
Sigma-Aldrich siRNA for TFAP2C  Sigma-Aldrich shRNA for TFAP2C  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003222 REFSEQ mRNAs for TFAP2C gene: NM_003222.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003222               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003222                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003222                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003222  Additional cDNA sequence: AK301572.1 AK314272.1 BC035664.1 BC051829.1 U85658.1 X95693.1 3 DOTS entries: DT.112064 DT.120798214 DT.95365798 24/59 AceView cDNA sequences (see all 59
):AI703244 AI077463 BC035664 AA035210 AA399334 BC051829 AI002216 AA394236 BE327517 AA632055 NM_003222 BX108462 AA300897 AW593477 CB305813 BF108600 AI638098 CD656949 BU679965 AI972428 CB985018 CA440747 BX369319 BU675297
highest scoring ESTs for TFAP2C:U85658 AA035210 AA169488 AA169676 AA399334 AA513207 AA581637 AA632055 AA975303 AI077463 Unigene Cluster for TFAP2C: Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) Hs.473152 [show with all ESTs]Unigene Representative Sequence: NM_003222
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000201031
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Expression for TFAP2C
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TFAP2C expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TFAP2C
1 / 2 / 3 5 probe-sets matching TFAP2C gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.473152
Expression variation in blood from EXPOLDB for TFAP2C |
Orthologs for TFAP2C
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for TFAP2C gene from 5/9 species (see all 9
)
About this table Species with no ortholog for TFAP2C
ENSEMBL Gene Tree for TFAP2C | Paralogs for TFAP2C(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TFAP2C gene
- TFAP2B2 TFAP2A2
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SNPs/Variants for TFAP2C(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for TFAP2C (up to first 250kb)
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Disorders & Mutations for TFAP2C
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 601602
6 Novoseek disease relationships for TFAP2C gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast carcinoma |
56.98 |
11 |
16867219 (3), 16636674 (2), 9113991 (2), 15623634 (1) (see all 6) |
| breast cancer |
43.49 |
14 |
9850080 (3), 15467710 (3), 18825690 (3), 18042070 (1) (see all 6) |
| carcinoma |
36.47 |
10 |
11429425 (3), 15623634 (1), 16420676 (1), 12490322 (1) (see all 8) |
| endometrial carcinoma |
27.60 |
1 |
9113991 (1) |
| tumors |
14.46 |
18 |
15623634 (5), 15830141 (3), 16416736 (2), 16867219 (2) (see all 6) |
| cancer |
2.24 |
1 |
17330235 (1) |
About this table
Tumor Gene Database: TFAP2C Breast Cancer Gene Database: TFAP2C
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Medical News for TFAP2C(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TFAP2C (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/68 PubMed articles for TFAP2C gene (see all 68
):- Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. (PubMed id 8661133)1, 2, 3, 4 Williamson J.A....Hurst H.C. (1996)
- Identification of ERF-1 as a member of the AP2 transcription factor family. (PubMed id 9113991)1, 3, 4 McPherson L.A.... Weigel R.J. (1997)
- Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. (PubMed id 15548692)1, 3, 4 Aqeilan R.I....Croce C.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. (PubMed id 12072434)3, 4 Eloranta J.J. and Hurst H.C. (2002)
- Human CREB-binding protein/p300-interacting transactivator with ED- rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PubMed id 11744733)3, 4 Braganca J.... Bhattacharya S. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells. (PubMed id 16867219)1, 3 Li H....Domann F.E. (2006)
- AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells. (PubMed id 16636674)1, 3 Li H....Domann F.E. (2006)
- Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region. (PubMed id 14565844)1, 3 Orso F....De Bortoli M. (2004)
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Search for TFAP2C
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TFAP2C
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TFAP2C
(According to HUGE)
About This Section
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Specialized Databases showing TFAP2C(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for TFAP2C(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for TFAP2C:

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| Antibodies & Assays for TFAP2C  (AP-2gamma) |
| | | | Search Tocris compounds for TFAP2C |
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Incremental update: 13 Oct 2009
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